Nat Prod Res. 2024 Feb 12:1-5. doi: 10.1080/14786419.2024.2314640. Online ahead of print.
ABSTRACT
Phytochemical investigation of the roots of Zygostelma benthamii Baill. (Apocynaceae) led to the isolation of eleven known compounds. The isolated compounds were identified by analysis of physical and spectroscopic data. We report three phenolic compounds (1-3), four triterpenoids (4-7), one coumarin (8), one lignan (9), one pregnane terpenoid (10), and one diterpenoid (11). It is the first time that Zygostelma benthamii is investigated, and this is therefore the first study of the Zygostelma genus. In addition, compound 7 and 11 are reported from the Apocynaceae family for the first time. Compounds 6, 7, 10 and 11 were evaluated against several cancer cell lines (KKU-M213B, KKU-100, KKU-M055, and A549) and Vero cells. Compound 10 showed strong anti-proliferative activity against all the selected cell lines, with IC50 values in the range of 1.70-6.8 µg/mL.
PMID:38343384 | DOI:10.1080/14786419.2024.2314640