University Daily Kansan, KS - May 7, 2008 Before her diagnosis in October of 2006, Jessica hadn’t worried much about cancer or even heard about adenoid cystic carcinoma, a cancer so rare that only ... |
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Adenoid Cystic Carcinoma (80 unread)
Google - Adenoid Cystic Carcinoma
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Living in Remission - University Daily Kansan
Posted: May 8th, 2008, 11:05pm EDT
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Holyoke marathon always looks ahead - The Republican - MassLive.com
Posted: May 1st, 2008, 1:52am EDT
Holyoke marathon always looks ahead
The Republican - MassLive.com, MA - May 1, 2008
Adam Bulewich (18:38) and Jessica Borsatti (20:42) were first at the Adenoid Cystic Carcinoma 5K, held Sunday at Springfield's Forest Park. ... -
Fashionable event pays tribute to RHS alumna - Palladium-Item
Posted: April 13th, 2008, 5:13am EDT
Fashionable event pays tribute to RHS alumna
Palladium-Item, IN - Apr 13, 2008
Richmond alumna Andrea "Andi" Whitesell O'Connell died at age 40 in July 2007 after a 21-year battle with adenoid cystic carcinoma, a rare cancer typically ... -
Hoosiers visiting Novi tomorrow - Novi News
Posted: April 11th, 2008, 11:05am EDT
Hoosiers visiting Novi tomorrow
Novi News, MI - Apr 11, 2008
Participants of the event will have the option of a 1-mile Fun Run, 10K run or 5K walk or run, to benefit research of adenoid cystic carcinoma, ... -
They will race to help a friend - The Republican - MassLive.com
Posted: April 10th, 2008, 6:56am EDT
They will race to help a friend
The Republican - MassLive.com, MA - Apr 10, 2008
"All of that money will go to the Adenoid Cystic Carcinoma Research Foundation for this type of cancer." The PASO holds the race in honor of a former female ... -
Walk for Andi this weekend - Novi News
Posted: April 10th, 2008, 4:53am EDT
Hoosiers visiting Novi tomorrow
Novi News, MI - Apr 11, 2008
Participants of the event will have the option of a 1-mile Fun Run, 10K run or 5K walk or run, to benefit research of adenoid cystic carcinoma, ... -
Walk for Andi this weekend - Novi News
Posted: April 10th, 2008, 4:53am EDT
Walk for Andi this weekend
Novi News, MI - Apr 10, 2008
But on July 31, 2007, at the age of 40, the South Lyon resident lost a 21-year fight against adenoid cystic carcinoma. Gone, but never forgotten, ... -
Walk for Andi this weekend - Novi News
Posted: April 10th, 2008, 4:53am EDT
Walk for Andi this weekend
Novi News, MI - Apr 10, 2008
But on July 31, 2007, at the age of 40, the South Lyon resident lost a 21-year fight against adenoid cystic carcinoma. Gone, but never forgotten, ... -
Family Raises Money For Rare Cancer In Their Mother's Memory - WDIV
Posted: April 8th, 2008, 6:58pm EDT
Family Raises Money For Rare Cancer In Their Mother's Memory
WDIV, MI - Apr 8, 2008
Andi was just 19 years old when she was diagnosed with a rare form of cancer called adenoid cystic carcinoma or ACC. The cancer begins in the secretory ... -
Kaiser Patient Gets Surprise Up-Front Charge - CBS 5
Posted: April 8th, 2008, 5:53pm EDT
Kaiser Patient Gets Surprise Up-Front Charge
CBS 5, CA - Apr 8, 2008
So, he went for a second opinion at UCSF and was told, "You have adenoid cystic carcinoma and you need to know that this is nearly always fatal, ... -
Community connections - Detroit Free Press
Posted: April 7th, 2008, 1:05am EDT
Family Raises Money For Rare Cancer In Their Mother's Memory
WDIV, MI - Apr 8, 2008
Andi was just 19 years old when she was diagnosed with a rare form of cancer called adenoid cystic carcinoma or ACC. The cancer begins in the secretory ...
Community connections Detroit Free Press
all 2 news articles -
Community connections - Detroit Free Press
Posted: April 7th, 2008, 1:05am EDT
Community connections
Detroit Free Press, United States - Apr 7, 2008
Organizers say they hope to raise $30000 for research for adenoid cystic carcinoma, which killed Andrea Whitesell O'Connell. She left behind a husband and ... -
COMMUNITY CONNECTIONS - Detroit Free Press
Posted: April 6th, 2008, 1:12am EDT
COMMUNITY CONNECTIONS
Detroit Free Press, United States - 19 hours ago
Organizers say they hope to raise $30000 for research for adenoid cystic carcinoma, which killed Andrea Whitesell O'Connell. She left behind a husband and ... -
COMMUNITY CONNECTIONS - Detroit Free Press
Posted: April 6th, 2008, 1:12am EDT
COMMUNITY CONNECTIONS
Detroit Free Press, United States - Apr 6, 2008
Organizers say they hope to raise $30000 for research for adenoid cystic carcinoma, which killed Andrea Whitesell O'Connell. She left behind a husband and ... -
Seabrook home receives makeover - Business Gazette
Posted: April 2nd, 2008, 6:29pm EDT
Business GazetteSeabrook home receives makeover
Business Gazette, MD - Apr 2, 2008
Sharon Bailey, 59, has adenoid cystic carcinoma, an incurable form of cancer; a mentally-retarded adult daughter, Sonya, 39, for whom she is the primary ... -
Retiring chaplain relies on humor, family, faith - Coon Rapids Herald
Posted: April 2nd, 2008, 3:37pm EDT
Retiring chaplain relies on humor, family, faith
Coon Rapids Herald, MN - Apr 2, 2008
The medical tag for Grant’s terminal condition is adenoid cystic carcinoma, a cancer that started in his salivary gland and travels through nerve roots, ... -
Events to raise money in Andi's memory - Palladium-Item
Posted: March 31st, 2008, 5:02am EDT
Events to raise money in Andi's memory
Palladium-Item, IN - Mar 31, 2008
Its goal is to battle adenoid cystic carcinoma, the slow-growing cancer that O'Connell fought for more than half her life. Contributions also will be used ... -
Live, love and laugh for Andi - South Lyon Herald
Posted: March 27th, 2008, 5:29am EDT
Live, love and laugh for Andi
South Lyon Herald, MI - Mar 27, 2008
But on July 31, 2007, at the age of 40, the South Lyon resident lost a 21-year fight against adenoid cystic carcinoma. Gone, but never forgotten, ... -
Live, love and laugh for Andi - South Lyon Herald
Posted: March 27th, 2008, 5:29am EDT
Live, love and laugh for Andi
South Lyon Herald, MI - Mar 27, 2008
But on July 31, 2007, at the age of 40, the South Lyon resident lost a 21-year fight against adenoid cystic carcinoma. Gone, but never forgotten, ... -
Catholic Central High in Novi to Host 10K/5K Run, 5K-Walk and Fun ... - NewsReleaseWire.com (press release)
Posted: March 22nd, 2008, 1:57pm EDT
NewsReleaseWire.com (press release)Catholic Central High in Novi to Host 10K/5K Run, 5K-Walk and Fun ...
NewsReleaseWire.com (press release) - Mar 22, 2008
Andi died in July 2007 at the age of 40, ending a 21-year battle with adenoid cystic carcinoma (ACC), a rare cancer typically originating in the salivary ... -
On the run - The Ann Arbor News - MLive.com
Posted: March 21st, 2008, 9:03am EDT
On the run
The Ann Arbor News - MLive.com, MI - Mar 21, 2008
Cause: Finding a cure for Adenoid Cystic Carcinoma, a disease that claimed the life of one of Sadler's neighbors. The second annual Book'n 5K and 1-Mile ... -
Love and death - Roanoke Times
Posted: March 16th, 2008, 11:33pm EDT
Love and death
Roanoke Times, VA - Mar 15, 2008
Cliff was diagnosed with cancer -- adenoid cystic carcinoma of the soft palate. "You think, 'Oh my, I'm going to die,' " Cliff said. ... -
Two Women Fight One Battle - Dunn Daily Record
Posted: March 13th, 2008, 12:27pm EDT
Two Women Fight One Battle
Dunn Daily Record, NC - Mar 13, 2008
Mrs. Hinshaw was diagnosed with Adenoid cystic carcinoma. According to the Cancer Health Center's Web site, medmd.com, this type of cancer is relatively ... -
Trick golfer entertains 152 at ‘Spirit of the Y’ dinner - Republican & Herald
Posted: March 6th, 2008, 12:44am EST
Trick golfer entertains 152 at ‘Spirit of the Y’ dinner
Republican & Herald, PA - Mar 5, 2008
... and a club to help him overcome the challenges he faced when he was diagnosed in 1988 with adenoid cystic carcinoma, a cancer of the salivary glands. ... -
Moving tale an early entry in short story competition - Luton Today
Posted: February 22nd, 2008, 10:09am EST
Moving tale an early entry in short story competition
Luton Today, UK - Feb 22, 2008
Andrea suffered from a rare from of cancer, adenoid cystic carcinoma, and passed away on New Year's Eve. Juliet, 37, who teaches psychology at Wootton Upper ... -
Moving tale an early entry in short story competition - Luton Today
Posted: February 22nd, 2008, 10:09am EST
Moving tale an early entry in short story competition
Luton Today, UK - Feb 22, 2008
Andrea suffered from a rare from of cancer, adenoid cystic carcinoma, and passed away on New Year's Eve. Juliet, 37, who teaches psychology at Wootton Upper ...
Trial - Adenoid Cystic Carcinoma
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CBT-1 and Paclitaxel in Treating Patients With Refractory, Recurrent, or Advanced Metastatic Solid Tumors
Posted: April 12th, 2008, 10:00am EDT
Condition: Cancer
Interventions: Drug: MDR modulator CBT-1; Drug: paclitaxel; Drug: technetium 99m sestamibi; Procedure: chemosensitization/potentiation therapy; Procedure: drug resistance inhibition treatment; Procedure: parenteral chemotherapy; Procedure: radionuclide imaging
Sponsor: National Cancer Institute (NCI)
Recruiting - verified April 2008 -
External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases
Posted: March 14th, 2008, 10:00am EDT
Condition: Cancer
Interventions: Drug: indinavir sulfate; Drug: ritonavir; Procedure: antiangiogenesis therapy; Procedure: drug modulation therapy; Procedure: enzyme inhibitor therapy; Procedure: radiation therapy; Procedure: radiosensitization
Sponsor: Oncology Institute of Southern Switzerland - Lugano
Recruiting - verified March 2008 -
Bortezomib and Cetuximab in Treating Patients With Advanced Solid Tumors
Posted: February 22nd, 2008, 10:00am EST
Conditions: Breast Cancer; Colorectal Cancer; Head and Neck Cancer; Kidney Cancer; Lung Cancer; Pancreatic Cancer; Sarcoma; Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: bortezomib; Drug: cetuximab; Procedure: enzyme inhibitor therapy; Procedure: monoclonal antibody therapy
Sponsors: Masonic Cancer Center at University of Minnesota; National Cancer Institute (NCI)
Active, not recruiting - verified March 2008 -
Bortezomib and Gemcitabine in Treating Older Patients With Advanced Solid Tumors
Posted: February 20th, 2008, 10:00am EST
Conditions: Breast Cancer; Colorectal Cancer; Head and Neck Cancer; Kidney Cancer; Lung Cancer; Ovarian Cancer; Pancreatic Cancer; Prostate Cancer; Sarcoma; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: bortezomib; Drug: gemcitabine hydrochloride; Procedure: antiangiogenesis therapy; Procedure: chemotherapy; Procedure: enzyme inhibitor therapy; Procedure: pharmacological study
Sponsors: Masonic Cancer Center at University of Minnesota; National Cancer Institute (NCI)
Recruiting - verified March 2008
PubMed - Adenoid Cystic Carcinoma
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Adenoid cystic carcinoma of trachea treated with adjuvant hypofractionated tomotherapy. Case report and literature review.
Fetched: May 13th, 2008, 9:00pm EDT
Related Articles Adenoid cystic carcinoma of trachea treated with adjuvant hypofractionated tomotherapy. Case report and literature review.
Tumori. 2008 Jan-Feb;94(1):121-5
Authors: Alongi F, Di Muzio N, Motta M, Broggi S, De Martin E, Bolognesi A, Cattaneo M, Calandrino R, Fazio F
Adenoid cystic carcinoma, also called cylindroma, is the second most common histological type of tracheal malignancy but represents 1% of all respiratory tract cancers. We report a case of a 59-year-old patient submitted to an incomplete resection of the trachea and subsequently treated with adjuvant tomotherapy. There have been no reports in the literature regarding intensity-modulated radiation therapy with linac or tomotherapy systems in adenoid cystic carcinoma of the trachea. The present clinical case demonstrates the feasibility of adjuvant intensity-modulated radiation therapy techniques for optimizing the dose coverage of the tumor bed while sparing surrounding normal tissues. A dosimetric comparison between the tomotherapy plan and a 3-dimensional conformal radiotherapy plan is also reported. We demonstrate that tomotherapy permits an increase in the dose per fraction without important acute adverse effects. At 24 months' follow-up, our patient shows no evidence of disease with negative histological findings.
PMID: 18468347 [PubMed - in process]
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[Effects of genistein on the expressions of cell apoptosis-related proteins in salivary adenoid cystic carcinoma cell line SACC-83.]
Fetched: May 13th, 2008, 9:00pm EDT
Related Articles [Effects of genistein on the expressions of cell apoptosis-related proteins in salivary adenoid cystic carcinoma cell line SACC-83.]
Shanghai Kou Qiang Yi Xue. 2008 Apr;17(2):196-9
Authors: Ma J, Wang J, Zhong M, Wang ZY
PURPOSE: To investigate the molecular mechanism of cell apoptosis induced by tyrosine protein kinase inhibitor, genistein, in human salivary adenoid cystic carcinoma cell line SACC-83. METHODS: SACC-83 cells cultured in vitro were treated with genistein, the expressions of bax, bcl-2 and survivin proteins were detected with Western blotting, and the results were quantitatively analyzed by FluorChem V2.0 software, statistical analysis was performed with analysis of variance using SPSS11.5 software package. RESULTS: With the increase of concentration of genistein and the elongation of time, the expression of bax protein was significantly increased, but the expression of bcl-2 and survivin proteins was significantly decreased. Treated with 220mumol/L genistein for 3 days, the expression level of bax protein was 3.43 folds of the control group (P<0.01),but the expression level of bcl-2 and survivin proteins was respectively 85%(P<0.05) and 35%(P<0.01) of the control group. CONCLUSION: The cell apoptosis induced by genistein in human salivary adenoid cystic carcinoma cell line SACC-83 may be associated with the upregulation of bax protein expression,and the downregulations of bcl-2 and survivin proteins expression. Supported by Scientific Research Plan of Education Bureau of Liaoning Province(Grant No.05L533).
PMID: 18470428 [PubMed - in process]
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Perineural tumor spread.
Fetched: May 10th, 2008, 9:00pm EDT
Related Articles Perineural tumor spread.
Neuroimaging Clin N Am. 2008 May;18(2):413-29
Authors: Maroldi R, Farina D, Borghesi A, Marconi A, Gatti E
Perineural spread (PNS) refers to the extent of tumor cells or other nonneoplastic lesions along the tissues of the nerve sheath, its overall incidence ranges from 2.5% to 5%. PNS is more frequently associated with carcinoma arising from minor or major salivary glands (more often adenoid cystic carcinoma), mucosal or cutaneous squamous cell carcinoma, basal cell carcinoma, melanoma, lymphoma, and sarcoma. Although PNS was previously associated with worsening prognosis, increasing evidence shows that cure is possible. Therefore, radiologists must be aware of the relevant cranial nerve anatomy and thoroughly scrutinize not only the nerves close to the primary tumor site but also the whole neural pathways that can be accessed by PNS. Equally critical is knowledge of the radiologic appearance of perineural tumor extension and the best imaging strategies to detect PNS.
PMID: 18466839 [PubMed - in process]
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Salivary gland cancers: current treatments, molecular characteristics and new therapies.
Fetched: May 10th, 2008, 9:00pm EDT
Related Articles Salivary gland cancers: current treatments, molecular characteristics and new therapies.
Expert Rev Anticancer Ther. 2008 Apr;8(4):645-52
Authors: Chandana SR, Conley BA
Salivary gland cancers are relatively rare and quite diverse. Current therapy relies on local ablation. There are few large clinical trials or randomized trials to guide treatment, especially for metastatic disease. This article reviews the epidemiology, staging, molecular characteristics, and treatment evidence for the most common types of salivary cancers and suggests potential future diagnostic and treatment directions. Progress in understanding the molecular and cell biology of salivary gland cancers may lead to the development of targeted therapies in these rare tumors. Multidisciplinary and multi-institutional collaborative studies are needed to help improve survival in salivary gland cancers.
PMID: 18402531 [PubMed - indexed for MEDLINE]
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Lymph node metastases in malignant tumors of the paranasal sinuses: prognostic value and treatment.
Fetched: May 9th, 2008, 9:00pm EDT
Related Articles Lymph node metastases in malignant tumors of the paranasal sinuses: prognostic value and treatment.
Arch Otolaryngol Head Neck Surg. 2008 Feb;134(2):170-7
Authors: Cantù G, Bimbi G, Miceli R, Mariani L, Colombo S, Riccio S, Squadrelli M, Battisti A, Pompilio M, Rossi M
OBJECTIVE: To assess the frequency of nodal involvement and its prognostic value in malignant tumors of the paranasal sinuses, particularly in maxillary sinus squamous cell carcinoma. DESIGN: Retrospective review. SETTING: Tertiary cancer center. PATIENTS: The medical records of 704 consecutive patients surgically treated for malignant tumors of the paranasal sinuses from January 1968 to March 2003 were reviewed. The tumors were staged according to American Joint Committee on Cancer-International Union Against Cancer 2002 classification. Only patients with clinically positive nodes underwent a neck dissection. MAIN OUTCOME MEASURES: Lymph node metastases (at presentation or during follow-up, occurring alone, or with concurrent local recurrence and/or distant metastasis). Also analyzed were local recurrence (occurring alone or with concurrent distant metastasis), distant metastasis (occurring alone), and overall survival. RESULTS: The tumor site was the ethmoid sinus in 305 cases and maxillary sinus in 399 cases. At baseline, 5 patients (1.6%) in the ethmoid sinus group and 33 (8.3%) in the maxillary sinus group presented with positive nodes (P < .001); during follow-up, nodal recurrences (alone or simultaneous with T and/or M recurrence) occurred in 15 and 51 patients, respectively, and the corresponding 5-year incidence estimates were 4.3% and 12.5% (P = .001). The highest incidence of node metastases was found in maxillary sinus squamous cell carcinoma, particularly in T2 tumors. Five-year overall survival estimates were 45.3% for patients with N0 tumors and 0% for those with N+ (N1, N2, or N3) ethmoid sinus tumors, and 50.6% and 16.8%, respectively, for patients with maxillary sinus tumors. CONCLUSIONS: Lymph node metastases are a poor prognostic factor for patients with malignant tumors of the paranasal sinuses. The incidence of these metastases is low, particularly in ethmoid sinus tumors. A prophylactic treatment of the neck in patients with N0 tumors (surgery or radiotherapy) might be considered in T2 squamous cell carcinoma of the maxillary sinus and in undifferentiated carcinoma of the ethmoid sinus.
PMID: 18283160 [PubMed - indexed for MEDLINE]
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Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours.
Fetched: May 6th, 2008, 9:00pm EDT
Related Articles Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours.
J Oral Pathol Med. 2008 May;37(5):309-18
Authors: Vargas PA, Cheng Y, Barrett AW, Craig GT, Speight PM
BACKGROUND: Recent studies have proposed that minichromosome maintenance (Mcm) proteins may be sensitive proliferation markers and may serve as novel biomarkers for prognostication and diagnosis of various pre-malignant and malignant lesions. The aims of this study were to determine the expression of Mcm-2, Ki-67 and geminin in salivary gland (SG) tumours, and to evaluate their usefulness for diagnosis or for prediction of tumour behaviour. METHODS: Tissue from 62 SG tumours was assembled in tissue microarray format. There were 13 adenoid cystic carcinomas (ACC), 10 carcinoma ex pleomorphic adenomas (CEPA), 10 mucoepidermoid carcinomas (MEC), 10 polymorphous low-grade adenocarcinomas (PLGA), 10 pleomorphic adenomas (PA) and nine acinic cell carcinomas (AcCC). Clinicopathological data were collected retrospectively and immunohistochemical analyses of Mcm-2, Ki-67 and geminin were performed on all lesions. Labelling index (LI) for each marker was determined by counting the percentage of positive cells in six random fields from three arrays per case. RESULTS: Mcm-2 expression was higher than Ki-67 and geminin in all tumours studied. Mcm-2 LI was higher in ACC (28.2 +/- 19.2%) than in CEPA, AcCC, MEC, PA and PLGA (5.3 +/- 4.1%, P = 0.001). Mcm-2 LI was higher in CEPA (20.4 +/- 5.0%) than in PA (6.9 +/- 5.0%, P = 0.001). LI did not correlate to tumour grade or outcome for any of the markers or tumour types. CONCLUSIONS: The findings suggest that Mcm-2 may be a sensitive proliferation marker in SG tumours and may be useful for differential diagnosis between PA and CEPA, and ACC and PLGA. Further studies are warranted to assess the value of Mcm-2 as a predictor of recurrence and survival.
PMID: 18248354 [PubMed - indexed for MEDLINE]
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Extent of surgery in the management of locally advanced sinonasal malignancies.
Fetched: May 3rd, 2008, 9:00pm EDT
Related Articles Extent of surgery in the management of locally advanced sinonasal malignancies.
Head Neck. 2008 Feb;30(2):222-9
Authors: Resto VA, Chan AW, Deschler DG, Lin DT
BACKGROUND: The relative importance of surgery within multimodality regimens commonly used to treat advanced sinonasal malignancies remains unknown. METHODS: One hundred two patients with locally advanced sinonasal cancers treated with proton beam radiation therapy with or without surgery were retrospectively reviewed. Extent of surgery and outcome variables of local control, disease-free survival, and overall survival were evaluated. Patterns of failure were also assessed. RESULTS: Extent of surgery correlated with disease-free survival and overall survival rates. Local control rate, however, was independent of the degree of surgical resection achieved. Overall, treatment failure most commonly resulted from distant metastases, which occurred in 30% of patients and also correlated with extent of surgical resection. Tumor type-specific outcomes reveal differences associated with the extent of surgery achieved. CONCLUSION: High-dose radiotherapy with proton beam resulted in excellent local control rates in patients with locally advanced sinonasal cancer, irrespective of the extent of surgery. Complete resection, however, was predictive of improved disease-free survival and decreased rate of distant metastasis.
PMID: 17902164 [PubMed - indexed for MEDLINE]
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Primary cutaneous adenoid cystic carcinoma: a case report and review of the literature.
Fetched: April 30th, 2008, 9:00pm EDT
Related Articles Primary cutaneous adenoid cystic carcinoma: a case report and review of the literature.
Cutis. 2008 Mar;81(3):243-6
Authors: Barnes J, Garcia C
Primary cutaneous adenoid cystic carcinoma is a rare cancer, with only 61 cases reported in the literature. We report an additional case and review the latest recommendations for workup and treatment.
PMID: 18441847 [PubMed - in process]
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Primary Adenoid Cystic Carcinoma of the Conjunctiva Arising From the Accessory Lacrimal Glands: A Clinicopathologic Study of Three Cases.
Fetched: April 25th, 2008, 9:00pm EDT
Related Articles Primary Adenoid Cystic Carcinoma of the Conjunctiva Arising From the Accessory Lacrimal Glands: A Clinicopathologic Study of Three Cases.
Cornea. 2008 May;27(4):494-497
Authors: Font RL, Valle MD, Avedaño J, Longo M, Boniuk M
PURPOSE:: To report 3 cases of primary adenoid cystic carcinoma originating from the accessory and/or ectopic lacrimal glands of the conjunctiva. METHODS:: We examined 3 conjunctival tumors histopathologically. The specimens were fixed in 10% formalin. Sections were cut at 5 mum, and the slides were stained with hematoxylin-eosin, periodic acid-Schiff, alcian blue, and colloidal iron methods. RESULTS:: We report 3 conjunctival tumors that histopathologically proved to be adenoid cystic carcinomas that had arisen from the accessory lacrimal glands of the conjunctiva (cases 1 and 2) and from ectopic lacrimal gland tissue (case 3). The age of the patients ranged between 53 and 68 years. In 2 of the cases, the tumor involved the tarsal conjunctiva. The third patient had a mass involving the limbal conjunctiva and two thirds of the cornea inferiorly. Histopathologically, acini of accessory lacrimal glands of the conjunctiva were found near the neoplastic lobules in 2 of the tumors. Foci of perineural invasion were observed in 1 of the tumors (case 1). Follow-up examination showed no evidence of recurrence or metastatic disease in cases 1 and 2 (10 and 8 years, respectively). In case 3, the patient was alive and without any evidence of recurrence 1 year after surgical excision of the mass. CONCLUSIONS:: Adenoid cystic carcinoma arising from the accessory lacrimal glands of the conjunctiva is a rare occurrence. Only 2 previously reported cases have appeared in the literature, and to our knowledge, there are no reports of this tumor arising from ectopic lacrimal gland tissue in the conjunctiva. Follow-up studies are mandatory to evaluate the biologic behavior of the tumor.
PMID: 18434856 [PubMed - as supplied by publisher]
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Perineural invasion through the maxillary division of the right trigeminal nerve in a rare case of nasolabial malignant peripheral nerve sheath tumor.
Fetched: April 24th, 2008, 9:00pm EDT
Related Articles Perineural invasion through the maxillary division of the right trigeminal nerve in a rare case of nasolabial malignant peripheral nerve sheath tumor.
AJNR Am J Neuroradiol. 2008 Feb;29(2):396-7
Authors: Sempere-Ortega C, Martinez-San-Millan J
SUMMARY: We report the CT and MR imaging findings in a patient with malignant peripheral nerve sheath tumor in the right nasolabial area, which exhibited typical imaging features of cystic adenoid carcinoma.
PMID: 18039752 [PubMed - indexed for MEDLINE]
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Pericardial effusion as primary manifestation of metastatic cutaneous adenoid cystic carcinoma: Diagnostic cytopathology from an exfoliative sample.
Fetched: April 18th, 2008, 9:00pm EDT
Related Articles Pericardial effusion as primary manifestation of metastatic cutaneous adenoid cystic carcinoma: Diagnostic cytopathology from an exfoliative sample.
Diagn Cytopathol. 2008 May;36(5):351-4
Authors: Benchetritt M, Butori C, Long E, Ilie M, Ferrari E, Hofman P
Adenoid cystic carcinoma (ACC) occurs not only as a tumor of salivary glands, but also in very unusual locations, such as in the skin. Only very few cases of primary cutaneous of ACC have metastasized to the lymph nodes and lungs. We present a 53-year-old man with metastasis of the pericardium from a primary cutaneous ACC (PCACC) of the scalp, which had been surgically treated 14 years ago. Exfoliative cytologic findings from pericardial effusion included small clusters of basaloid cells with occasional cystlike spaces containing mucoid material. To our knowledge, this is the first case of pericardial metastasis from a PCACC. Diagn. Cytopathol. 2008;36:351-354. (c) 2008 Wiley-Liss, Inc.
PMID: 18418850 [PubMed - in process]
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[Primary Adenoid Cystic Carcinoma of esophagus.]
Fetched: April 18th, 2008, 9:00pm EDT
Related Articles [Primary adenoid cystic carcinoma of esophagus]
Rev Gastroenterol Peru. 2008 Jan-Mar;28(1):50-5
Authors: Perea Guerrero H, Frisancho Velarde O, Palomino Portilla A
We presented the case of a man of 86 years with 6 months of progressive dysphagia, weight loss and edema of lower limbs. He had both severe microcític anemia and hypoalbuminemia. The contrasted x-ray showed the esophagus with irregular edges that compromised their cervical and distal portions. In the computerized axial tomography cervical adenopathies, bilateral pleural effusion and pronouncing esophagic thickening were evident. In endoscopy dispersed elevated lesions were observed from the underlying area of the cricopharinx, some with nodular and tumor like aspect, that distributed throughout the esophagus until an area of stenosis (32 cm of dental arches); the estenosis was tapestried with an irregular and easy bleeding mucosa. The histological study revealed adenoid cystic carcinoma of esophagus, with positive inmunocytochemical to cytokeratin. We showed the clinical-pathological findings and images of this case and we reviewed reports of this rare entity.
PMID: 18418449 [PubMed - in process]
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Expression of RUNX3 in salivary adenoid cystic carcinoma: Implications for tumor progression and prognosis.
Fetched: April 16th, 2008, 9:00pm EDT
Related Articles Expression of RUNX3 in salivary adenoid cystic carcinoma: Implications for tumor progression and prognosis.
Cancer Sci. 2008 Apr 11;
Authors: He JF, Ge MH, Zhu X, Chen C, Tan Z, Li YN, Gu ZY
Runt-related transcription factor-3 (RUNX3), being a tumor suppressor gene in gastric cancer, plays an important role in inhibiting cellular growth by participating in the transforming growth factor-beta-dependent apoptosis. The aim of this study was to determine the expression of RUNX3 in normal salivary glands and adenoid cystic carcinomas (ACCs), comparing the results with clinicopathological factors and patient survival. The quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis and Western blot analysis revealed the expression of RUNX3 both in normal salivary glands and ACCs. Nuclear and cytoplasmic immunoreactivities against RUNX3 in ductal luminal cells and acinous cells, but immunonegative in myoepithelial cells, were detected in normal salivary glands. In ACC, the RUNX3 immunostaining was shown in the cytoplasm of tumor cells; however, no nuclear location of RUNX3 was found. Lower RUNX3 expression showed significant correlation to distant metastasis and histological growth pattern (P = 0.009 and P = 0.025, respectively). On univariate analysis, low level of RUNX3 immunolabeling (P = 0.012), stage T4 (P = 0.017), lymph node involvement (P = 0.007), and distant metastasis (P < 0.001) were significantly associated with decreased overall survival. Multivariate analysis showed only distant metastasis had an independent prognostic effect on overall survival (P = 0.043). Our results demonstrate the expression of RUNX3 in normal salivary glands and salivary ACCs. The low level of RUNX3 protein in salivary ACCs might play a pivotal role in tumor progression and have prognostic values in ACCs.
PMID: 18410404 [PubMed - as supplied by publisher]
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Primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis: a case report.
Fetched: April 12th, 2008, 9:00pm EDT
Related Articles Primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis: a case report.
J Oral Sci. 2008 Mar;50(1):95-8
Authors: Shamim T, Varghese VI, Shameena PM, Sudha S
Intraosseous adenoid cystic carcinoma is an extremely rare neoplasm with only 17 cases reported previously. A case of primary intraosseous adenoid cystic carcinoma of the mandible with lung metastasis in a 45-year-old man is reported, together with a brief review of the literature. (J. Oral Sci. 50, 95-98, 2008).
PMID: 18403891 [PubMed - in process]
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[Fluorescent imaging of angiogeneosis and spontaneous metastasis in transplanted hepatoma: experiment with mice]
Fetched: April 10th, 2008, 9:00pm EDT
Related Articles [Fluorescent imaging of angiogeneosis and spontaneous metastasis in transplanted hepatoma: experiment with mice]
Zhonghua Yi Xue Za Zhi. 2007 Dec 11;87(46):3307-9
Authors: Wang Y, Feng GS, Tian H, Zhang ZH, Xiong T
OBJECTIVE: To establish stable enhanced green fluorescent protein (GFP) -expressing human adenoid cystic carcinoma (ACC-M-GFP) cell lines with high lung metastatic potential, and to study the value and influential factor of in vivo monitoring of metastasis and angiogenesis by fluorescent imaging. METHODS: Human adenoid cystic carcinoma cell line ACC-M-GFP labeled with enhanced GFP was established. ACC-M-GFP cells of the dose 10(7)/ml were injected subcutaneously into two nude mice. Once the subcutaneous tumor reached 0.5 cm in diameter, it was removed, cut into 1 mm3 pieces, and implanted into the left hepatic lobe of 8 nude mice. The animals were observed by whole-body optical imaging system and stereofluorescent microscope each two weeks from the fourth week after transplantation. One mouse was killed and autopsied after each examination. The livers, lungs, and adjacent organs, such as diaphragm and lymph nodes were excised, and fluorescent imaging of different organs separately was studied. Hepatoma was cryostat sectioned and angiogenesis was visualized under fluorescence microscope. The findings of fluorescent imaging were compared with those of HE staining on routine paraffin sections. RESULTS: Liver tumors were transplanted successfully in all 8 nude mice. By whole-body optical system, the fluorescent signal from the liver tumor was detected through a skin-flap window after 6 - 8 weeks. Tumors were visualized directly through skin after 8 - 10 weeks. The hepatoma became enormous after 12 - 14 weeks, when the fluorescent signal of abdominal metastasis was detected. Metastasis of lung and lymph node was found by single organ imaging after 16 -18 weeks. By stereofluorescent microscope, microvessels were detected after 4 weeks, and a large quantity of tumor vessels like black branch stripes were found after 12 - 14 weeks. The tumor vessels appeared as dark tubiform network against the green fluorescence of the implanted tumor in section. CONCLUSION: Fluorescent imaging provides a method to monitor tumor growing, infiltrating, metastasis and angiogenesis in real time in vivo.
PMID: 18396632 [PubMed - in process]
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Adenoid cystic carcinoma of intraoral minor salivary glands.
Fetched: April 9th, 2008, 9:00pm EDT
Related Articles Adenoid cystic carcinoma of intraoral minor salivary glands.
Oral Oncol. 2008 Apr 5;
Authors: Bianchi B, Copelli C, Cocchi R, Ferrari S, Pederneschi N, Sesenna E
We present a retrospective multicentric study of 67 patients with adenoid cystic carcinomas of the intraoral minor salivary glands, who were diagnosed and treated between 1986 and 2004 in the Operative Units of Maxillofacial Surgery of the University of Parma and of the Bellaria Hospital in Bologna. There were 28 males and 39 females with a mean age of 54.5 years (range 28-84 years). The palate was the most common site of involvement, with 71.6% of cases. All the patients were treated with surgery as the primary modality. Neck dissection was performed in 9% of the patients, and more than half (59.7%) were treated with adjuvant radiation therapy. All surviving patients had a minimum of 2 years follow-up, with a range of 2-20 years (median: 12 years). Of the 67 patients examined in this study, 19 were dead at the end of the follow-up, 16 of them due to tumor disease. Distant or loco-regional recurrence was documented in 29 of the 67 patients (43.3%). Disease-free intervals ranged from 1 month to 12 years. Twenty-two percent of patients had loco-regional failure, whereas 29.8% had distant metastases. The disease specific survival rates were 76.1% at 5 years and 74% at 10 and 15 years.The actuarial loco-regional control rates at 5-, 10- and 15-years were 79.7%, 74.8% and 70%, respectively. The actuarial freedom from distant relapse was 76.5% at 5 years, 64.9% at 10 years and 61.1% at 15 years. Stage T, cervical lymph node metastasis and surgical margin status proved to make a statistically significant contribution when describing the outcome.
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