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Trial - Anal Cancers (100 unread)

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Effect of Intraperitoneal Ropivacaine on Visceral Pain After Laparoscopic Gastrectomy

Posted: November 24th, 2023, 3:00am GMT

Conditions: Laparoscopic Gastrectomy; Ropivacaine
Interventions: Drug: 0.5% Ropivacaine; Drug: Saline
Sponsors: SanQing Jin
Not yet recruiting
A Real-World Study to Learn More About the Order of Different Treatments and Their Effects in People With Metastatic Colorectal Cancer Receiving Their Third and Fourth Line of Treatment

Posted: November 17th, 2023, 3:00am GMT

Conditions: Metastatic Colorectal Cancer
Interventions: Drug: Regorafenib (Stivarga, BAY73-4506)
Sponsors: Bayer
Not yet recruiting
Electroacupuncture (EA) Promotes Gastrointestinal Functional Recovery After Radical Colorectal Cancer Surgery

Posted: November 13th, 2023, 3:00am GMT

Conditions: Colorectal Cancer; Gastrointestinal Dysfunction
Interventions: Device: Electroacupuncture group; Other: Sham EA group
Sponsors: Shanghai Yueyang Integrated Medicine Hospital; ShuGuang Hospital; Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Baoshan hospital of Integrated Traditional Chinese and Western Medicine
Not yet recruiting
Global Burden Estimation of Human Papillomavirus (GLOBE-HPV)

Posted: November 13th, 2023, 3:00am GMT

Conditions: HPV Infection
Interventions: Other: Urine Sample Collection; Other: Self-collected Vaginal Swab; Other: Blood Samples
Sponsors: International Vaccine Institute; London School of Hygiene and Tropical Medicine; Karolinska Institutet; Centers for Disease Control and Prevention
Not yet recruiting
The Impact of Preoperative Bowel Exercise on Postoperative Bowel Functions in Gynecologic Malignancies

Posted: November 2nd, 2023, 2:00am GMT

Conditions: Paralytic Ileus; Nausea; Defecation Disorder
Interventions: Procedure: Abdominal Exercise (digital rectal stimulation, abdominal massage)
Sponsors: Tepecik Training and Research Hospital
Completed
RATME vs LATME in Middle and Low Rectal Cancer

Posted: October 27th, 2023, 2:00am GMT

Conditions: Total Mesorectal Excision; Rectal Neoplasms; Robotic Surgical Procedures; Laparoscopy
Interventions: Procedure: Robotic-assisted total mesorectal excision; Procedure: laparoscopic-assisted total mesorectal excision
Sponsors: The First Hospital of Jilin University; Jilin Provincial Tumor Hospital; Daping Hospital and the Research Institute of Surgery of the Third Military Medical University; The Second Affiliated Hospital of Dalian Medical University; The Second Affiliated Hospital of Harbin Medical University
Not yet recruiting
Total Neoadjuvant Treatment for pMMR Locally Advanced Low Rectal Cancer: Anti-PD-1 Antibody With FOLFOXIRI and Preoperative Radiation Therapy

Posted: October 25th, 2023, 2:00am GMT

Conditions: Colorectal Cancer
Interventions: Drug: Serplulimab + FOLFOXIRI; Radiation: Radiation therapy
Sponsors: Sun Yat-sen University
Not yet recruiting
Study of Patients With Thrombotic Microangiopathy Associated With Mitomycin C, Treated or Not With Eculizumab

Posted: October 24th, 2023, 2:00am GMT

Conditions: Thrombotic Microangiopathies
Sponsors: University Hospital, Strasbourg, France
Recruiting
Reconstruction of the Pelvic Floor and Perineal Wound After Rectal ELAPE

Posted: October 4th, 2023, 2:00am GMT

Conditions: Rectum Cancer
Interventions: Procedure: Plastic surgery of the pelvic floor and perineal wound with counter-displaced skin-subcutaneous fascial flaps after extralevatory abdominal-perineal extirpation of the rectum; Procedure: Plastic surgery of the pelvic floor and perineal wound with local tissues; Procedure: Plastic surgery of the pelvic floor and perineal wound with mesh endoprosthesis
Sponsors: Kuban State Medical University; State Budget Public Health Institution Scientific Research Institute - Ochapovsky Regional Clinical Hospital; City Clinical Oncology Hospital No 1
Not yet recruiting
Pre-Rehabilitation for Female Patients Undergoing Pelvic Radiotherapy

Posted: September 28th, 2023, 2:00am GMT

Conditions: Dyspareunia; Pelvic Pain; Sexual Dysfunction; Radiation Toxicity
Interventions: Behavioral: Pelvic health therapy; Device: Dilator feasability
Sponsors: Indiana University
Not yet recruiting
Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for pMMR/MSS Locally Advanced Mid-low Rectal Cancer

Posted: September 27th, 2023, 2:00am GMT

Conditions: Locally Advanced Rectal Cancer
Interventions: Drug: capecitabine; Drug: tislelizumab; Drug: thymalfasin; Radiation: long-term radiotherapy
Sponsors: Beijing Friendship Hospital; Peking Union Medical College Hospital
Not yet recruiting
Evaluation of Intra- and Peri-operative Complications and Disease-free Survival in Rectal Cancer Patients Undergoing Oncological Resective Surgery and Concomitant Bariatric Surgery

Posted: September 27th, 2023, 2:00am GMT

Conditions: Morbid Obesity; Rectal Cancer; Surgical Outcomes
Interventions: Procedure: BIB positioning
Sponsors: Federico II University
Recruiting
Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS)

Posted: September 25th, 2023, 2:00am GMT

Conditions: KSHV Inflammatory Cytokine Syndrome (KICS); Kaposi Sarcoma Herpesvirus -Associated Multicentric Castleman Disease
Interventions: Drug: Pacritinib
Sponsors: National Cancer Institute (NCI)
Not yet recruiting
MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach

Posted: September 22nd, 2023, 2:00pm GMT

Conditions: Anal Squamous Cell Carcinoma
Interventions: Radiation: Radiotherapy - Low risk group; Radiation: Radiotherapy - Standard risk group; Radiation: Radiotherapy - Intermediate risk group; Radiation: Radiotherapy - High risk group
Sponsors: University Health Network, Toronto
Recruiting
Preoperative FOLFOXIRI Chemotherapy Combined With Lateral Lymph Node Dissection in Rectal Cancer

Posted: September 21st, 2023, 2:00am GMT

Conditions: Lymph Node Metastasis; Cancer of Rectum and Anus; Oxaliplatin; Intestinal Neoplasms; Gastrointestinal Neoplasms; Rectal Diseases; Rectal Neoplasms
Interventions: Drug: Experimental: FOLFOXIRI and Lateral lymph node dissection; Drug: Preoperative long-term concurrent chemoradiotherapy and Lateral lymph node dissection
Sponsors: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Enrolling by invitation
Salvage Chemotherapy Versus Total Mesorectal Resection for Local Resection Rectal Cancer Patients

Posted: September 21st, 2023, 2:00am GMT

Conditions: Chemotherapy Effect; Rectal Cancer
Interventions: Procedure: Radical total mesorectal excision; Other: Salavge Adjuvant Chemoradiotherapy
Sponsors: Sun Yat-sen University
Recruiting
A Study to Evaluate the Efficacy, Safety, and Immunogenicity of SCT1000 in Healthy Women Aged 18-45 Years

Posted: September 18th, 2023, 2:00am GMT

Conditions: HPV InfectioN; HPV-Related Carcinoma
Interventions: Biological: Recombinant 14-Valent Human Papillomavirus Vaccine（Insect Cell）; Biological: placebo
Sponsors: Sinocelltech Ltd.; Guangxi Center for Disease Control and Prevention; Henan Center for Disease Control and Prevention; Sichuan Center for Disease Control and Prevention; Shanxi Center for Disease Control and Prevention; Yunnan Center for Disease Control and Prevention
Active, not recruiting
Utilization of Transanal Endoscopy in the Treatment of Anastomotic Stenosis

Posted: September 14th, 2023, 2:00am GMT

Conditions: Anastomotic Stenosis
Interventions: Procedure: Transanal and transabdominal combined endoscopic resection of rectal stenosis and anal reconstruction
Sponsors: Sun Yat-sen University
Recruiting
Treatment of Low Locally Advanced Rectal Cancer With Radiotherapy Removal TNT Plus Neoadjuvant Therapy

Posted: September 13th, 2023, 2:00pm GMT

Conditions: Rectal Cancer
Interventions: Drug: CapeOX + cetuximab; Drug: CapeOX + bevacizumab; Radiation: radiotherapy
Sponsors: Tang-Du Hospital
Not yet recruiting
Applications of Fluorescence Imaging Guided Lymph Node Dissection and Fluorescence Angiography of Inferior Mesenteric Artery Assisted Left Colic Artery Preservation

Posted: September 13th, 2023, 2:00am GMT

Conditions: Fluorescence; Indocyanine Green; Rectal Cancer Surgery
Interventions: Device: Fluorescence laparoscopic system
Sponsors: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Recruiting
An Observational Study to Learn More About the Long-Term Responses to Treatment With Regorafenib in Patients With Metastatic Colorectal Cancer in the United States

Posted: September 8th, 2023, 2:00am GMT

Conditions: Metastatic Colorectal Cancer
Interventions: Drug: Regorafenib (Stivarga, BAY73-4506)
Sponsors: Bayer
Completed
Clostridioides Difficile Infection: Analyzing CLInic Evolution and Bacterial Clearance

Posted: September 8th, 2023, 2:00am GMT

Conditions: Clostridium Difficile Infections
Sponsors: Fondation Hôpital Saint-Joseph
Recruiting
Conservative Treatment or Resuturing Among Women With Perineal Wound Dehiscence After Vaginal Labour

Posted: September 7th, 2023, 2:00am GMT

Conditions: Dehiscence Wound; Secondary Perineal Tear; Episiotomy; Dehiscence
Interventions: Other: Clinical examination and pictures; Other: Questionnaire
Sponsors: Herlev Hospital
Recruiting
Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for Locally Advanced Mid-low Rectal Cancer

Posted: September 6th, 2023, 2:00am GMT

Conditions: Colorectal Neoplasms
Interventions: Drug: Thymalfasin
Sponsors: Beijing Friendship Hospital
Not yet recruiting
Efficacy of Ultrasound-assisted Caudal Epidural Pulsed Radiofrequency for Anal Pain in Cancer Patients,

Posted: August 24th, 2023, 2:00pm GMT

Condition: Perineal Pain
Intervention: Procedure: US assisted caudal epidural pulsed radiofrequency
Sponsor: Assiut University
Not yet recruiting
Pudendal Nerve Block With Bupivacaine Alone and Bupivacaine With Methylene Blue for Postoperative Analgesia

Posted: August 14th, 2023, 2:00am GMT

Conditions: Hemorrhoids; Anal Fissure and Fistula; Perianal Abscess; Perianal Fistula; Pilonidal Sinus; Perianal Skin Tags
Interventions: Other: Ultrasound guided Pudendal nerve block
Sponsors: Nepal Mediciti Hospital
Recruiting
Combination of AK104 and Neoadjuvant Chemoradiotherapy in pMMR/MSS Locally Advanced Rectal Cancer

Posted: August 8th, 2023, 2:00am GMT

Conditions: Locally Advanced Rectal Cancer
Interventions: Drug: AK104; Drug: Capecitabine; Radiation: Neoadjuvant Radiotherapy
Sponsors: Sun Yat-sen University; Akeso; Haplox Biotechnology Co., Ltd.
Recruiting
A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors

Posted: August 3rd, 2023, 2:00am GMT

Conditions: Head and Neck Cancer; Cervical Cancer; Non-small Cell Carcinoma; Melanoma; Ovarian Cancer; Anogenital Cancers; HPV - Anogenital Human Papilloma Virus Infection; HPV-Related Cervical Carcinoma; HPV-Related Carcinoma; HPV-Related Squamous Cell Carcinoma; HPV-Related Malignancy; HPV-Related Adenocarcinoma; HPV Positive Oropharyngeal Squamous Cell Carcinoma; HPV-Related Adenosquamous Carcinoma; HPV-Associated Vaginal Adenocarcinoma; HPV-Related Endocervical Adenocarcinoma; HPV-Related Anal Squamous Cell Carcinoma; HPV-Related Verrucous Carcinoma; HPV-Related Penile Squamous Cell Carcinoma; HPV-Related Vulvar Squamous Cell Carcinoma; HPV Positive Rectal Squamous Cell Carcinoma
Interventions: Biological: TSC-204-A0201; Biological: TSC-204-C0702; Biological: TSC-200-A0201; Biological: TSC-204-A0201 + TSC-204-C0702; Biological: TSC-204-A0201 + TSC-200-A0201; Biological: TSC-204-C0702 + TSC-200-A0201; Biological: TSC-204-A0201 + TSC-203-A0201; Biological: TSC-204-C0702 + TSC-203-A0201; Biological: TSC-200-A0201 + TSC-203-A0201
Sponsors: TScan Therapeutics, Inc.
Recruiting
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer, Cancer CARE Beyond Walls

Posted: August 1st, 2023, 2:00pm GMT

Conditions: Advanced Malignant Solid Neoplasm; Anal Carcinoma; Biliary Tract Carcinoma; Bladder Carcinoma; Breast Carcinoma; Carcinoid Tumor; Cervical Carcinoma; Colorectal Carcinoma; Gastric Carcinoma; Glioblastoma; Head and Neck Carcinoma; HER2-Positive Breast Carcinoma; Lung Carcinoma; Lung Small Cell Carcinoma; Malignant Germ Cell Tumor; Neuroendocrine Carcinoma; Ovarian Carcinoma; Pancreatic Carcinoma; Prostate Small Cell Neuroendocrine Carcinoma; Prostate Carcinoma
Interventions: Procedure: Clinical Encounter; Other: Home Health Encounter; Other: Quality-of-Life Assessment; Other: Questionnaire Administration
Sponsors: Mayo Clinic
Recruiting
Study to Assess the Safety and Efficacy of Subcutaneously Injected Risankizumab in Adult Participants With Genital or Scalp Psoriasis

Posted: August 1st, 2023, 2:00am GMT

Conditions: Genital Psoriasis; Scalp Psoriasis
Interventions: Drug: Risankizumab; Drug: Placebo for Risankizumab
Sponsors: AbbVie
Recruiting
Radical vs Local Excision for Rectal Cancer With Clinically Complete Remission

Posted: July 28th, 2023, 2:00pm GMT

Condition: Rectal Cancer
Intervention: Procedure: Surgery
Sponsor: National Taiwan University Hospital
Recruiting
A Chatbot Intervention for Reducing HPV Vaccine Hesitancy

Posted: July 25th, 2023, 2:00pm GMT

Conditions: Cervical Cancer; Anal Cancer; Penile Cancer
Interventions: Behavioral: Personalized Chatbot Intervention; Behavioral: Non-Personalized Chatbot Intervention; Behavioral: No Chatbot Control
Sponsor: University of Maryland, College Park
Recruiting
HRYZ-T101 Injection for HPV18 Positive Solid Tumor

Posted: July 19th, 2023, 2:00pm GMT

Conditions: Cervical Cancer; Head and Neck Squamous Cell Carcinoma; Carcinoma of Vagina; Carcinoma of Penis; Anal Cancer; Carcinoma of Vulva
Interventions: Biological: HRYZ-T101 Injection; Drug: Fludarabine + Cyclophosphamide
Sponsor: SYZ Cell Therapy Co..
Not yet recruiting
Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer

Posted: July 13th, 2023, 2:00pm GMT

Conditions: Rectal Neoplasms; Low Anterior Resection Syndrome; Anastomotic Leak; Quality of Life
Interventions: Procedure: Parks technique; Procedure: Bacon technique
Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
Not yet recruiting
Phase 1/2 Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

Posted: July 12th, 2023, 2:00pm GMT

Conditions: Advanced Solid Tumors
Interventions: Drug: LCB84; Drug: Anti-PD-1 monoclonal antibody
Sponsors: LegoChem Biosciences, Inc; AntibodyChem Biosciences, Inc.
Recruiting
A Study Regarding Tissue Response During and After Treatment for Anal Cancer

Posted: July 11th, 2023, 2:00pm GMT

Conditions: Anal Cancer
Interventions: Other: Biopsies
Sponsors: Sahlgrenska University Hospital, Sweden; Göteborg University
Not yet recruiting
A Multicenter Single-arm P2 to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy for cT2 Rectal Cancer

Posted: July 11th, 2023, 2:00pm GMT

Condition: Rectal Cancer
Interventions: Radiation: Radiation; Drug: Chemotherapy; Procedure: Surgery
Sponsor: Osaka University
Recruiting
Transanal Irrigation - Best Treatment Possibility for Low Anterior Resection Syndrome? Multicenter, Randomized Clinical Trial

Posted: June 27th, 2023, 2:00pm GMT

Conditions: Low Anterior Resection Syndrome
Interventions: Procedure: Transanal irrigation; Combination Product: Best supportive care
Sponsors: National Cancer Institute, Lithuania
Recruiting
REDEL Trial: Reduced Elective Nodal Dose for Anal Cancer Toxicity Mitigation

Posted: June 14th, 2023, 2:00pm GMT

Condition: Anal Cancer
Interventions: Radiation: Radiation (reduced elective nodal dose (30.6 Gy); Drug: Capecitabine; Drug: Mitomycin c
Sponsor: University of Cincinnati
Recruiting
A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

Posted: June 5th, 2023, 2:00am GMT

Conditions: Hidradenitis Suppurativa
Interventions: Drug: Upadacitinib; Drug: Placebo
Sponsors: AbbVie
Recruiting
Indocyanine Green-guided Lymphadenectomy in Laparoscopic Total Mesorectal Excision for Low Rectal Cancer After Neoadjuvant Chemoradiotherapy

Posted: May 24th, 2023, 2:00pm GMT

Conditions: Rectal Cancer; Lymph Node Cancer Metastatic
Intervention: Procedure: ICG-guided lymphadenectomy
Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Recruiting
COrSIcA: Disease Measurement

Posted: May 15th, 2023, 2:00pm GMT

Conditions: Anal Intraepithelial Neoplasia; Anal High-grade Squamous Intraepithelial Lesion; Anal HSIL
Intervention: Diagnostic Test: Physical examination
Sponsors: David Finch; Lancashire Teaching Hospitals NHS Foundation Trust
Not yet recruiting
Safety, PK and Efficacy of AI-061 in Advanced Solid Tumors

Posted: May 15th, 2023, 2:00pm GMT

Conditions: Melanoma; Non Small Cell Lung Cancer; Head and Neck Squamous Cell Carcinoma; High Grade Serous Adenocarcinoma of Ovary; Primary Peritoneal Carcinoma; Fallopian Tube Cancer; Endometrial Cancer; Cervical Cancer; Renal Cell Carcinoma; Bladder Cancer; Esophageal Cancer; Gastric Cancer; Gastroesophageal-junction Cancer; Colorectal Cancer; Anal Cancer; Hepatocellular Carcinoma; Bile Duct Cancer
Interventions: Drug: AI-061
Sponsors: OncoC4, Inc.; OncoC4 AU Pty Ltd; Avance Clinical
Recruiting
Total Neoadjuvant Therapy Combined With Tislelizumab for Local Advanced of Middle and Low Rectal Cancer

Posted: May 5th, 2023, 2:00pm GMT

Condition: Locally Advanced Rectal Cancer
Interventions: Combination Product: Long-course chemoradiation, with Tislelizumab (PD-1 inhibitor); Combination Product: Long-course chemoradiation, without Tislelizumab (PD-1 inhibitor)
Sponsor: Beijing Friendship Hospital
Recruiting
An Observational Study Called STAR-T to Learn More About the Sequential Treatment With Regorafenib and TAS-102 in Adults With Metastatic Colorectal Cancer Under Real World Conditions

Posted: May 3rd, 2023, 2:00am GMT

Conditions: Metastatic Colorectal Cancer (mCRC)
Interventions: Drug: Regorafenib (BAY73-4506, Stivarga®); Drug: TAS-102 (trifluridine and tipiracil, Lonsurf®); Drug: Bevacizumab
Sponsors: Bayer
Active, not recruiting
Adaptive Radiation in Anal Cancer

Posted: May 1st, 2023, 2:00pm GMT

Condition: Anal Squamous Cell Carcinoma
Interventions: Radiation: Artificial Intelligence Guided Daily Radiotherapy Treatment Planning and Delivery; Drug: Mitomycin-C; Drug: 5-Fluorouracil; Drug: Capecitabine
Sponsors: Columbia University; Varian Medical Systems
Recruiting
Anal Cancer Risk In Women

Posted: April 28th, 2023, 2:00pm GMT

Conditions: Anal Cancer; Human Papilloma Virus; Anal Intraepithelial Neoplasia; Genital Neoplasm; Genital Cancer
Intervention: Other: Dual Pathology
Sponsor: Imperial College London
Recruiting
Anal Intraepithelial Neoplasia and Anal Squamous Cell Carcinoma

Posted: April 28th, 2023, 2:00pm GMT

Conditions: Anal Cancer; Anal Squamous Intraepithelial Neoplasia
Intervention:
Sponsor: Imperial College London
Recruiting
Effects of Different Radiation Dosimetry for Anorectal Function of Patients With Pelvic Cancer

Posted: April 27th, 2023, 2:00pm GMT

Condition: Anorectal Cancer
Intervention: Radiation: IMRT
Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
Not yet recruiting
Safety and Effectiveness Evaluations of the COLO-BT as an Treatment to the Proctectomy.

Posted: April 24th, 2023, 2:00am GMT

Conditions: Colorectal Surgery; Colorectal Cancer; Rectal/Anal
Interventions: Device: COLO BT™; Other: Stoma Creation
Sponsors: JSR Medical Co., Ltd.
Recruiting
Implementation of Anal Cancer Screening and Treatment in Nigeria

Posted: April 18th, 2023, 2:00pm GMT

Condition: Education, Medical
Intervention: Behavioral: Enhanced Training on screening and treatment of HSIL (e-STH)
Sponsors: University of Maryland, Baltimore; National Cancer Institute (NCI)
Recruiting
HRYZ-T101 TCR-T Cell for HPV-18 Positive Advanced Solid Tumor

Posted: March 28th, 2023, 2:00pm GMT

Conditions: Cervical Cancer; Head and Neck Squamous Cell Carcinoma; Oropharyngeal Cancer; Vagina Tumor; Carcinoma of Penis; Anal Carcinoma; Carcinoma of Vulva
Interventions: Drug: Fludarabine + Cyclophosphamide; Biological: HRYZ-T101 TCR-T Cell
Sponsors: HRYZ Biotech Co.
Recruiting
Natural Orifice Specimen Extraction Surgery for Colorectal Cancer

Posted: February 23rd, 2023, 3:00pm GMT

Condition: Colorectal Cancer
Intervention: Procedure: Natural Orifice Specimen Extraction
Sponsor: Chang Gung Memorial Hospital
Not yet recruiting
Defining the Natural History of Squamous Cell Carcinoma in Fanconi Anemia

Posted: January 18th, 2023, 3:00am GMT

Conditions: Fanconi Anemia; Inherited Bone Marrow Failure Syndrome
Sponsors: National Cancer Institute (NCI)
Recruiting
E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

Posted: January 17th, 2023, 3:00pm GMT

Conditions: Cervical Cancer; Throat Cancer; Oropharynx Cancer; Anal Cancer; Vulva Cancer; Vaginal Cancer; Penile Cancer; Metastatic Cancer; HPV-Related Malignancy; HPV-Related Carcinoma; HPV-Related Cervical Carcinoma; HPV-Related Squamous Cell Carcinoma; HPV-Related Adenocarcinoma; HPV Positive Oropharyngeal Squamous Cell Carcinoma; HPV-Associated Vaginal Adenocarcinoma; HPV-Related Adenosquamous Carcinoma; HPV-Related Endocervical Adenocarcinoma; HPV-Related Anal Squamous Cell Carcinoma; HPV-Related Penile Squamous Cell Carcinoma; HPV-Related Vulvar Squamous Cell Carcinoma; HPV Positive Rectal Squamous Cell Carcinoma
Interventions: Biological: E7 TCR-T cells
Sponsors: Christian Hinrichs
Recruiting
Paula Method of Exercises in Patients With LARS Syndrome:Randomized Controlled Trial

Posted: January 12th, 2023, 3:00am GMT

Conditions: Low Anterior Resection Syndrome
Interventions: Other: Paula Method of muscle exercises
Sponsors: Hadassah Medical Organization
Recruiting
The Application Value of da Vinci Linear Cutting Stapler SureForm in Robotic Anus Preserving Surgery for Rectal Cancer

Posted: December 28th, 2022, 3:00pm GMT

Conditions: Rectal Cancer; Robotic; Anastomotic Leak; Laparoscopic
Interventions: Device: Surform
Sponsors: Nanchang University
Recruiting
Collecting Blood and Tissue Sample Donations for Research for HIV/AIDS-Related Cancers

Posted: December 23rd, 2022, 3:00pm GMT

Conditions: Anal Carcinoma; Hematopoietic and Lymphoid Cell Neoplasm; HIV Infection; Kaposi Sarcoma; Lymphoma; Malignant Solid Neoplasm; Multicentric Castleman Disease; Plasmablastic Lymphoma; Recurrent Kaposi Sarcoma; Recurrent Lymphoma; Recurrent Plasmablastic Lymphoma; Transplant-Related Kaposi Sarcoma
Interventions: Procedure: Biospecimen Collection
Sponsors: AIDS Malignancy Consortium; National Cancer Institute (NCI)
Recruiting
Impact of Dietary Fiber Supplementation on Colonic Mucosal Microbiome

Posted: December 9th, 2022, 3:00pm GMT

Conditions: Benign Colorectal Neoplasm; Non-Neoplastic Anal Disorder
Interventions: Dietary Supplement: Dietary Fiber; Procedure: Proctoscopy or anoscopy with Biopsy; Other: Questionnaire Administration
Sponsor: OHSU Knight Cancer Institute
Recruiting
Anastomotic Leakage After Colon Cancer Surgery

Posted: December 8th, 2022, 3:00am GMT

Conditions: Adult Patients; Intestinal Continuity (Anastomosis); Colon Cancer
Interventions: Procedure: Any kind of colectomy
Sponsors: Hospital San Carlos, Madrid; Spanish Association of Surgeons (AEC); Hospital Universitario La Fe; Complejo Hospitalario Universitario de Vigo
Enrolling by invitation
E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers

Posted: December 7th, 2022, 3:00am GMT

Conditions: HPV-Associated Cervical Carcinoma; HPV-Related Carcinoma; HPV-Related Malignancy; HPV Positive Oropharyngeal Squamous Cell Carcinoma; HPV-Related Adenocarcinoma; HPV-Related Adenosquamous Carcinoma; HPV-Related Squamous Cell Carcinoma; HPV-Related Anal Squamous Cell Carcinoma; HPV-Related Penile Squamous Cell Carcinoma; HPV-Related Vulvar Squamous Cell Carcinoma; HPV-Related Endocervical Adenocarcinoma; Cervical Cancer; Oropharynx Cancer; Anal Cancer; Vulvar Cancer; Penile Cancer; Vaginal Cancer
Interventions: Drug: Conditioning, E7 TCR-T cells, and aldesleukin
Sponsors: Christian Hinrichs; National Cancer Institute (NCI)
Not yet recruiting
Human Papillomavirus in Young People Epidemiological Research 4

Posted: October 20th, 2022, 2:00pm GMT

Conditions: Human Papillomavirus Infection; HPV; HPV Infection; Anal Cancer; Cancer; Men; HPV 16 Infection
Intervention:
Sponsors: Monash University; The Alfred; University of Melbourne
Recruiting
Human Papillomavirus in Young People Epidemiological Research 3

Posted: October 20th, 2022, 2:00pm GMT

Conditions: Human Papillomavirus Infection; HPV; HPV Infection; Anal Cancer; Cancer; Men; HPV 16 Infection
Intervention:
Sponsors: Monash University; The Alfred; University of Melbourne
Recruiting
Optimizing Screening for Cervical Cancer Among Women Living With HIV in the Dominican Republic

Posted: September 27th, 2022, 2:00pm GMT

Conditions: Malignant Female Reproductive System Neoplasm
Interventions: Procedure: Biospecimen Collection; Other: Interview
Sponsors: Fred Hutchinson Cancer Center; National Cancer Institute (NCI); US-Latin American-Caribbean HIV/HPV-Cancer Prevention Clinical Trials Network (ULACNet); Instituto Dermatológico Dominicano y Cirugía de Piel (IDCP)
Recruiting
Anal HSIL Screening Algorithm

Posted: September 8th, 2022, 2:00am GMT

Conditions: Anal High-grade Squamous Intraepithelial Lesion
Interventions: Procedure: OPTIMIZATION PHASE
Sponsors: Institute of HIV Research and Innovation Foundation, Thailand; National Institutes of Health (NIH); amfAR, The Foundation for AIDS Research
Recruiting
Use of a Screening Tool to Describe HIV-Related Cancer Burden and Patient Characteristics in the AMC

Posted: August 22nd, 2022, 2:00pm GMT

Conditions: HIV-Associated Malignant Neoplasm; HIV Infections; Cancer; AIDS Related Lymphoma; AIDS-related Kaposi Sarcoma; AIDS-Related Malignancy; Anal Cancer; HPV-Related Malignancy
Interventions: Other: Non-Interventional; Other: Non-Interventional Follow-up
Sponsors: AIDS Malignancy Consortium; National Cancer Institute (NCI)
Recruiting
CRP-guided Transanal Drainage Removal After Rectal Surgery

Posted: August 16th, 2022, 2:00am GMT

Conditions: Rectal Cancer; Anastomotic Leak
Interventions: Device: removal of transanal drainage tube
Sponsors: Qilu Hospital of Shandong University
Recruiting
Timing of Transcutaneous Acupoint Electrical Stimulation on Postoperative Recovery in Geriatric Patients With Gastrointestinal Tumor

Posted: August 1st, 2022, 2:00am GMT

Conditions: Postoperative Cognitive Dysfunction
Interventions: Other: Transcutaneous acupoint electrical stimulation
Sponsors: Subei People's Hospital of Jiangsu Province
Not yet recruiting
Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)

Posted: July 18th, 2022, 2:00pm GMT

Conditions: Pleural Effusion, Malignant; Ascites, Malignant; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Carcinoma, Renal; Carcinoma, Small Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Neuroendocrine; Carcinoma, Thymic; Carcinoma, Pancreatic; Carcinoma Breast; Carcinoma, Ovarian; Carcinoma Bladder; Carcinoma of Unknown Primary; Carcinoma of the Head and Neck; Carcinoma of the Oropharynx; Carcinoma of the Larynx; Carcinoma of the Bladder; Carcinoma of Esophagus; Carcinoma of the Nasopharynx; Carcinoma of the Penis; Carcinoma of the Cervix; Carcinoma of the Anus; Carcinoma of the Vulva; Carcinoma of the Appendix; Carcinoma of the Oral Cavity; Cholangiocarcinoma; Melanoma; Mesothelioma; Pancreatic Cancer
Intervention:
Sponsors: Travera Inc; xCures
Recruiting
Re-optimization Based Online Adaptive Radiotherapy of Anal Cancer

Posted: June 30th, 2022, 2:00pm GMT

Conditions: Anal Cancer; Anal Carcinoma; Anal Squamous Cell Carcinoma
Interventions: Radiation: online adaptive radiotherapy
Sponsors: Herlev Hospital
Recruiting
The Argentina Brief Colonoscopy Difficulty Score (ABCD)

Posted: June 21st, 2022, 2:00am GMT

Conditions: Colorectal Cancer; Diagnoses Disease; Polyp of Colon; Adenoma Colon
Interventions: Diagnostic Test: Diagnostic high-definition white-light (HDWL) colonoscopy
Sponsors: Institute of Gastroenterology and Advance Endoscopy; Austral University, Argentina; Hospital Nacional Profesor Alejandro Posadas
Completed
Study of SQZ-eAPC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors

Posted: May 3rd, 2022, 2:00pm GMT

Conditions: Adult Solid Tumor
Interventions: Biological: SQZ-eAPC-HPV; Biological: Pembrolizumab
Sponsors: SQZ Biotechnologies
Active, not recruiting
Chemotherapy Combined With High-dose Radiotherapy for Low Rectal Cancer Using MR Guided Linear Accelerator

Posted: April 21st, 2022, 2:00am GMT

Conditions: Rectal Cancer
Interventions: Radiation: Magnetic resonance guided radiotherapy; Drug: Chemotherapy
Sponsors: Sun Yat-sen University
Enrolling by invitation
Lopinavir/Ritonavir in PLWH With High-Grade AIN

Posted: April 19th, 2022, 2:00pm GMT

Conditions: High-Grade Anal Intraepithelial Neoplasia
Interventions: Drug: Lopinavir / Ritonavir
Sponsors: University of Wisconsin, Madison; Wisconsin Partnership Program
Recruiting
A Study to Assess the Reduction of Human Papillomavirus (HPV) Viral Infectivity and Transmission in HPV-Positive Women After Vaccination With 9vHPV (RIFT-HPV)

Posted: April 19th, 2022, 2:00pm GMT

Conditions: Cervical Intraepithelial Neoplasia Grade I/ II/ III (CIN I/II/III); Human Papillomavirus (HPV) Infections; High-risk HPV; HPV-16/ 18
Intervention: Biological: Nonavalent HPV vaccine (9vHPV/Gardasil-9™).
Sponsors: Miquel Angel Pavon Ribas; Hospital del Mar; Catalan Institute of Health
Recruiting
Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors

Posted: April 6th, 2022, 2:00am GMT

Conditions: CNS Cancer; Head and Neck Cancer; GI Cancer; Gynecologic Cancer; Prostate Cancer; Thoracic Cancer; Breast Cancer
Interventions: Radiation: Pencil Beam Scanning Proton Therapy
Sponsors: The New York Proton Center
Recruiting
An Integrated Optimization of Surgery and Radiotherapy Techniques to Improve Cosmetic Outcome and Quality of Life in Breast Conserving Therapy for Breast Cancer Patients (STARLINGS Study)

Posted: March 2nd, 2022, 3:00am GMT

Conditions: Breast Fibrosis; Breast Cancer; Breast Cancer Female; Breast Neoplasms; Breast Carcinoma in Situ; Breast Carcinoma
Interventions: Other: no intervention
Sponsors: Erasmus Medical Center; Stichting BeterKeten, the Netherlands; Albert Schweitzer hospital, Dordrecht, the Netherlands; Franciscus Gasthuis and Vlietland Hospital, Rotterdam and Schiedam, the Netherlands; Maasstad hospital, Rotterdam, the Netherlands
Enrolling by invitation
HPV Vaccine Effectiveness Study in Rwandan Women Living With HIV

Posted: February 21st, 2022, 3:00am GMT

Conditions: Cervical Cancer; Human Papilloma Virus; Human Immunodeficiency Virus; HPV-Related Carcinoma
Interventions: Procedure: Blood collection; Procedure: Oral, cervicovaginal and anal specimen collection; Procedure: Anoscopy & Biopsy of Acetowhite Lesions; Procedure: Colposcopy & Biopsy of Acetowhite Lesions; Procedure: Ablative Treatment; Procedure: LEEP (Loop Electrosurgical Excision Procedure)
Sponsors: Montefiore Medical Center; National Cancer Institute (NCI); Rwanda Military Hospital; University of Rwanda
Recruiting
Effects of Modified Precision Functional Sphincter-Preserving Surgery (PPS) on Ultralow Rectal Cancer

Posted: February 18th, 2022, 3:00pm GMT

Conditions: Rectum Cancer; Stoma Colostomy; Faecal Incontinence; Leakage, Anastomotic
Intervention:
Sponsor: Shanghai 10th People's Hospital
Recruiting
Myriad™ Augmented Soft Tissue Reconstruction Registry

Posted: February 17th, 2022, 3:00am GMT

Conditions: Abdominal Wound Dehiscence; Necrotizing Soft Tissue Infection; Lower Extremity Wound; Pilonidal Sinus; Anal Fistula; Hidradenitis Suppurativa; Pressure Injury
Interventions: Device: Myriad Matrix™ and Myriad Morcells™
Sponsors: Aroa Biosurgery Limited
Recruiting
Single-Dose HPV Vaccination for the Prevention of Cervical Cancer in Young Adult Women in Costa Rica, The PRISMA ESCUDDO Trial

Posted: February 14th, 2022, 3:00am GMT

Conditions: Cervical Carcinoma; Human Papillomavirus Infection
Interventions: Biological: Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed; Other: Questionnaire Administration; Biological: Recombinant Human Papillomavirus Bivalent Vaccine; Biological: Recombinant Human Papillomavirus Nonavalent Vaccine
Sponsors: National Cancer Institute (NCI)
Active, not recruiting
Screening Women With Prior HPV for Anal Neoplasia

Posted: February 1st, 2022, 3:00pm GMT

Conditions: HPV-related Lower Genital Tract Neoplasias; HPV-related Anal Neoplasias; Early Stage Lower Genital Tract Cancers
Interventions: Diagnostic Test: Diagnostic tests for anal cancer screening
Sponsors: Icahn School of Medicine at Mount Sinai; M.D. Anderson Cancer Center; Medical University of South Carolina
Recruiting
4-Point Therapy Response Score With PET/CT for Anal Squamous Cell Cancer

Posted: November 22nd, 2021, 3:00pm GMT

Conditions: Anal Squamous Cell Carcinoma; Stage 0 Anal Cancer AJCC v8; Stage I Anal Cancer AJCC v8; Stage II Anal Cancer AJCC v8; Stage IIA Anal Cancer AJCC v8; Stage IIB Anal Cancer AJCC v8; Stage III Anal Cancer AJCC v8; Stage IIIA Anal Cancer AJCC v8; Stage IIIB Anal Cancer AJCC v8; Stage IIIC Anal Cancer AJCC v8
Interventions: Procedure: Computed Tomography; Other: Electronic Health Record Review; Procedure: Follow-Up; Procedure: Positron Emission Tomography
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Active, not recruiting
Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery

Posted: November 8th, 2021, 3:00am GMT

Conditions: Anal Melanoma; Bladder Melanoma; Cervical Melanoma; Esophageal Melanoma; Gallbladder Melanoma; Mucosal Melanoma; Mucosal Melanoma of the Head and Neck; Mucosal Melanoma of the Urinary System; Oral Cavity Mucosal Melanoma; Penile Mucosal Melanoma; Rectal Melanoma; Recurrent Mucosal Melanoma; Sinonasal Mucosal Melanoma; Stage II Vulvar Cancer AJCC v8; Stage III Vulvar Cancer AJCC v8; Stage IV Vulvar Cancer AJCC v8; Urethral Melanoma; Vaginal Melanoma; Vulvar Melanoma
Interventions: Drug: Cabozantinib S-malate; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Biological: Nivolumab; Drug: Placebo Administration; Procedure: Positron Emission Tomography
Sponsors: National Cancer Institute (NCI)
Suspended
Screening Algorithms for Cervical and Anal High-Grade Squamous Intraepithelial Lesions in People With HIV in Mexico and Puerto Rico

Posted: October 12th, 2021, 2:00pm GMT

Conditions: AIDS-Related Anal Carcinoma; AIDS-Related Cervical Carcinoma; High Grade Anal Intraepithelial Neoplasia; High Grade Cervical Intraepithelial Neoplasia; HIV Infection
Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection - Anal; Procedure: Biospecimen Collection - Cervical; Procedure: Colposcopy; Procedure: High Resolution Anoscopy; Procedure: Imaging Technique
Sponsors: University of California, San Francisco; National Cancer Institute (NCI); US-Latin American-Caribbean HIV/HPV-Cancer Prevention Clinical Trials Network (ULACNet)
Recruiting
Inguinal Node Sparing Radiotherapy For Patients With Early Stage Anal Cancer

Posted: September 10th, 2021, 2:00pm GMT

Condition: Anal Canal Cancer
Intervention: Radiation: chemo-radiation treatment
Sponsor: AHS Cancer Control Alberta
Recruiting
Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)

Posted: August 30th, 2021, 2:00am GMT

Conditions: Human Papillomavirus
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
$Permalink for 'A Prospective Pilot Study to Assess the Efficacy of BOTOX-A in Patients With Low Anterior Resection Syndrome (LARS>20) and Refractory Medical Treatment After Rectal Resection'$
A Prospective Pilot Study to Assess the Efficacy of BOTOX-A in Patients With Low Anterior Resection Syndrome (LARS>20) and Refractory Medical Treatment After Rectal Resection

Posted: August 5th, 2021, 2:00am GMT

Conditions: Low Anterior Resection Syndrome (LARS>20); Refractory Medical Treatment After Rectal Resection
Interventions: Drug: BOTOX-A
Sponsors: University Hospital, Bordeaux
Terminated
Defining the Clinical Potential of Mass Response as a Biomarker for Patient Tumor Sensitivity to Drugs

Posted: August 2nd, 2021, 2:00pm GMT

Conditions: Stage III Breast Cancer; Stage IV Breast Cancer; Stage III Lung Cancer; Stage IV Lung Cancer; AML; Multiple Myeloma in Relapse; Carcinoma; Carcinoma, Pancreatic; Carcinoma of Lung; Carcinoma, Non-Small-Cell Lung; Carcinoma Breast; Carcinoma Prostate; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Carcinoma, Neuroendocrine; Carcinoma, Small Cell Lung; Carcinoma, Ovarian; Carcinoma Bladder; Carcinoma of Esophagus; Carcinoma Cervix; Carcinoma, Thymic; Carcinoma, Ductal; Carcinoma of the Head and Neck; Carcinoma of the Lip; Carcinoma of the Oral Cavity; Carcinoma of Unknown Primary; Carcinoma of the Skin; Carcinoma of the Anus; Carcinoma of the Larynx; Carcinoma of the Penis; Carcinoma of the Oropharynx; Carcinoma of the Appendix; Carcinoma of the Paranasal Sinus; Carcinoma of the Vulva; Malignant Pleural Effusion; Malignant Ascites; Mesothelioma; Cholangiocarcinoma
Intervention:
Sponsor: Travera Inc
Not yet recruiting
HPV Vaccination in HIV Infected and HIV Uninfected Adolescents in Eswatini

Posted: July 29th, 2021, 2:00am GMT

Conditions: HPV Infection; Hiv; HPV Vaccine
Interventions: Biological: Gardasil ® 9
Sponsors: Columbia University
Active, not recruiting
Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

Posted: June 18th, 2021, 2:00pm GMT

Conditions: AIDS-Related Anal Carcinoma; Anal Basaloid Squamous Cell Carcinoma; Anal Canal Cloacogenic Carcinoma; Anal Margin Squamous Cell Carcinoma; Anal Squamous Cell Carcinoma; HIV Infection; Rectal Squamous Cell Carcinoma; Stage I Anal Cancer AJCC v8; Stage II Anal Cancer AJCC v8; Stage II Rectal Cancer AJCC v8; Stage III Anal Cancer AJCC v8; Stage III Rectal Cancer AJCC v8
Interventions: Drug: Capecitabine; Drug: Fluorouracil; Radiation: Intensity-Modulated Radiation Therapy; Drug: Mitomycin; Biological: Nivolumab
Sponsors: National Cancer Institute (NCI)
Recruiting
Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Posted: June 1st, 2021, 2:00pm GMT

Conditions: Cancer Pain; Visceral Pain; Gastrointestinal Neoplasms; Cancer of Gastrointestinal Tract; Small Intestine Cancer; Pancreas Cancer; Liver Cancer; Colon Cancer; Biliary Tract Cancer; Stomach Cancer; Rectum Cancer; Peritoneal Cancer; Gastrointestinal Cancer Metastatic; Gastrointestinal Cancers - Anus; Gastrointestinal Cancers - Stomach; Gastrointestinal Cancers - Colorectal; Gastrointestinal Cancers - Small Intestine; Small Intestine Cancer Stage III; Small Intestine Cancer Stage IV; Small Intestine Cancer, Recurrent; Pancreas Cancer, Stage III; Pancreas Cancer, Stage IV; Pancreas Cancer, Metastatic; Pancreas Cancer, Recurrent; Liver Cancer Stage IIIa; Liver Cancer Stage IIIb; Liver Cancer Stage IIIc; Liver Cancer Stage IV; Colon Cancer Stage III; Colon Cancer Stage IV; Stomach Cancer Stage III; Stomach Cancer Stage IV; Stomach Cancer Recurrent; Rectum Cancer, Recurrent; Gastrointestinal Cancers - Liver; Anal Cancer; Anal Cancer Stage III; Anal Cancer Stage IV; Anal Cancer Recurrent; Anal Cancer Metastatic; Anal Cancer, Stage IIIA; Anal Cancer, Stage IIIB; Appendix Cancer; Ampullary Cancer; Bile Duct Cancer; Bile Duct Cancer Stage III; Bile Duct Cancer Stage IV; Bile Duct Cancer Stage IVA; Bile Duct Cancer Stage IVB; Bile Duct Cancer Recurrent; Carcinoid Tumor; Carcinoid Tumor of Pancreas; Carcinoid Tumor of Large Intestine; Carcinoid Tumor of GI System; Carcinoid Tumor of Colon; Carcinoid Tumor of Liver; Carcinoid Tumor of Cecum; Carcinoid Tumor of Ileum; Carcinoid Tumor of Rectum; Carcinoid Tumor of the Small Bowel; Carcinoid Tumor of the Stomach; Large Intestine Cancer; Esophagus Cancer; Esophagus Cancer, Stage III; Esophagus Cancer, Stage IV; Esophagus Cancer, Recurrent; Gallbladder Cancer; Gallbladder Cancer Stage III; Gallbladder Cancer Stage IV; Gastric (Stomach) Cancer; Neuroendocrine Tumor; Peritoneum Cancer; Rectal Cancer; Esophagus Cancer, Stage I; Esophagus Cancer, Stage II; Gallbladder Cancer Stage I; Gallbladder Cancer Stage II; Bile Duct Cancer Stage I; Bile Duct Cancer Stage II
Intervention: Device: PICO G2 4k
Sponsors: Cedars-Sinai Medical Center; National Cancer Institute (NCI)
Recruiting
Total Neoadjuvant Treatment Plus PD-1 in Mid-Low Locally Advanced Rectal Cancer

Posted: May 28th, 2021, 2:00am GMT

Conditions: Tislelizumab; Locally Advanced Rectal Cancer; Total Neoadjuvant Treatment; PD-1
Interventions: Drug: Sintilimab
Sponsors: The First Hospital of Jilin University
Active, not recruiting
Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV

Posted: May 26th, 2021, 2:00pm GMT

Conditions: Viral Associated Malignancies; Kaposi Sarcoma; EBV/KSHV-associated Lymphomas
Interventions: Drug: Pomalidomide; Drug: Nivolumab
Sponsors: National Cancer Institute (NCI)
Recruiting
Combination of Spartalizumab, mDCF and Radiotherapy in Patients With Metastatic Squamous Cell Anal Carcinoma

Posted: May 20th, 2021, 2:00pm GMT

Conditions: Squamous Cell Anal Carcinoma; Metastatic Squamous Cell Carcinoma
Intervention: Biological: Sample collection
Sponsors: Centre Hospitalier Universitaire de Besancon; National Cancer Institute, France; Novartis
Recruiting
Study of SQZ-AAC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors

Posted: May 19th, 2021, 2:00pm GMT

Conditions: Adult Solid Tumor
Interventions: Biological: SQZ-AAC-HPV; Drug: Ipilimumab; Drug: Nivolumab
Sponsors: SQZ Biotechnologies
Active, not recruiting
Detecting HPV DNA in Anal and Cervical Cancers

Posted: April 23rd, 2021, 2:00pm GMT

Conditions: Cervical Cancer; Anal Cancer; HPV-Related Anal Squamous Cell Carcinoma; HPV-Related Cervical Carcinoma; HPV-Related Carcinoma; Uterine Cervical Cancer
Interventions: Radiation: Radiation Treatment With or Without Chemotherapy; Other: Blood Sample Collection; Diagnostic Test: HPV Genotyping (HPV DNA Test); Diagnostic Test: Testing Archival Tumor Tissue; Other: Physical Exam; Diagnostic Test: Positron Emission Tomography Scan (PET Scan)/ Computed Tomography Scan (CT Scan)
Sponsor: University of Chicago
Recruiting
Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients With PD1-high mRNA Expressing Tumors

Posted: March 17th, 2021, 2:00pm GMT

Conditions: MSI-H Colorectal Cancer; Melanoma; Anal Carcinoma; Mesothelioma; Triple Negative Breast Cancer; Lung Adenocarcinoma; Cholangiocarcinoma; Cervical Carcinoma; Kidney Clear Cell Carcinoma; Stomach Adenocarcinoma; Esophageal Adenocarcinoma; Uterine Adenocarcinoma; Head and Neck Squamous Cell Carcinoma; Sarcoma; Lung Squamous Cell Carcinoma; Urothelial Carcinoma; Thyroid Carcinoma; Hepatocellular Carcinoma; Uveal Melanoma; HER2-positive Breast Cancer; Pancreatic Adenocarcinoma; Squamous Esophageal Carcinoma; Epithelial Ovarian Cancer; Uterine Carcinosarcoma; Small Cell Lung Cancer; Hormone Receptor Positive / HER2-negative Breast Cancer; Lung Adenocarcinoma EGFR-mutated/ ALK Traslocation; Colorectal Adenocarcinoma; Prostate Adenocarcinoma; Carcinoma of Unknown Primary; Other Histology
Interventions: Drug: Spartalizumab; Drug: Tislelizumab
Sponsors: SOLTI Breast Cancer Research Group; Novartis
Recruiting
Comparison of Functional Outcomes Between Transanal and Laparoscopic vs Open Ileal Pouch-Anal Anastomosis

Posted: January 25th, 2021, 3:00am GMT

Conditions: Ulcerative Colitis; Inflammatory Bowel Diseases; Ileal Pouch
Interventions: Procedure: ta-IPAA; Procedure: tabd-IPAA
Sponsors: Mount Sinai Hospital, Canada; Cedars-Sinai Medical Center; St Mary's Hospital, London; Universitaire Ziekenhuizen KU Leuven
Recruiting
Anti-PD-1 and mDCF Followed by Chemoradiotherapy in Patients With Stage III Squamous Cell Anal Carcinoma.

Posted: January 22nd, 2021, 3:00pm GMT

Condition: Squamous Cell Carcinoma of the Anus Stage III
Interventions: Biological: Blood sample collection; Procedure: Biopsy
Sponsors: Centre Hospitalier Universitaire de Besancon; Boehringer Ingelheim
Recruiting

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