Conditions: Children Brain Injury
Interventions: Device: pupillometer; Device: pupillometer
Sponsors: University Hospital, Grenoble
Not yet recruiting
Feeds
32878 items (32878 unread) in 74 feeds
Acinar Cell Carcinoma
(522 unread)
Acinic Cell Carcinoma
(306 unread)
Adenoid Cystic Carcinoma
(550 unread)
Adrenal Gland Cancer
(2410 unread)
Ampulla Of Vater
(469 unread)
Anal Cancer
(2709 unread)
Angiosarcoma
(990 unread)
Appendix Cancer
(684 unread)
Bile Duct Cancer
(4355 unread)
Brain and CNS
(6120 unread)
Carcinoid
(887 unread)
Endocrine/Neuroendocrine
(5825 unread)
Gall Bladder Cancer
(1132 unread)
Hemangioendothelioma
(1176 unread)
Hepatoblastoma
(770 unread)
Pancreas
(563 unread)
Phyllodes
(384 unread)
PMP and Mucinous Tumors
(477 unread)
Rhabdomyosarcoma
(1118 unread)
Sarcoma
(1431 unread)
Trial - Brain Tumor (100 unread)
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Quantitative Pupillometry in Brain Injury Children : Variation After Osmotherapy
Posted: October 15th, 2024, 11:00pm UTC
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TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas
Posted: October 14th, 2024, 11:00pm UTC
Conditions: Brain Tumor; Brain Metastases; Brain Cancer; Glioma; Gliomas, Malignant; Glioblastoma; Meningioma
Interventions: Biological: Tumor Infiltrating Lymphocytes (TIL); Drug: Cyclophosphamide; Drug: Fludarabine; Drug: Interleukin-2; Drug: Pembrolizumab
Sponsors: Essen Biotech
Not yet recruiting -
Feasibility of Accelerated, Personalized rTMS as an Adjuvant for Impulse Control Disorders: a Pilot Study
Posted: October 14th, 2024, 11:00pm UTC
Conditions: Impulse Control Disorder
Interventions: Device: Repetitive Transcranial Magnetic Stimulation (rTMS)
Sponsors: M.D. Anderson Cancer Center
Not yet recruiting -
Effect of Anodal Transcranial Direct Current Stimulation on Postdural Puncture Headache
Posted: October 14th, 2024, 11:00pm UTC
Conditions: Postdural Puncture Headache; Lumbar Puncture
Interventions: Device: active in therapeutic tDCS (Th-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS); Device: sham in therapeutic tDCS (Th-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS); Device: active in preventive tDCS (Pr-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS); Device: sham in preventive tDCS (Pr-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS)
Sponsors: Neuromed IRCCS
Completed -
Study in Patients With Breast Cancer Leptomeningeal Metastasis
Posted: October 11th, 2024, 11:00pm UTC
Conditions: Leptomeningeal Metastasis of Breast Cancer
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Avon Foundation
Not yet recruiting -
Prevalence of Major Vessels Underlying the Potential Incision Site for Emergency Front of Neck Airway Access in Adult Surgical Patients With Impalpable Neck Anatomy
Posted: October 11th, 2024, 11:00pm UTC
Conditions: Airway Complication of Anesthesia
Interventions: Device: Ultrasound
Sponsors: Mount Sinai Hospital, Canada
Not yet recruiting -
The Relationship Between Body Mass Index and Patient Outcomes in Low Flow Anaesthesia
Posted: October 10th, 2024, 11:00pm UTC
Conditions: Major Gynecological Cancer Surgery; Low Flow Anesthesia
Interventions: Procedure: the effect of body mass index during low-flow anesthesia
Sponsors: Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Not yet recruiting -
Window of Opportunity Study of DSP-0390 in Gliomas
Posted: October 10th, 2024, 11:00pm UTC
Conditions: Glioma, Malignant; Grade II Glioma; IDH Mutation
Interventions: Drug: DSP-0390
Sponsors: Washington University School of Medicine; Sumitomo Pharmaceuticals America
Not yet recruiting -
Personalized ViscoElastic Testing-guided Bleeding Management in Liver Surgery, Neurosurgery and Obstetrics
Posted: October 10th, 2024, 11:00pm UTC
Conditions: Thrombelastography; Liver Transplant; Postpartum Hemorrhage; Bleeding Disorder; Intracranial Hemorrhages
Interventions: Diagnostic Test: Viscoelastic testing
Sponsors: Medical University of Vienna; Synapse - Research Institute Maastricht
Recruiting -
Flexibility, Alcohol Misuse, and Excitation
Posted: October 10th, 2024, 11:00pm UTC
Conditions: Behavioral Flexibility; Healthy Volunteers; High Risk Alcohol Use
Interventions: Device: 10 Hz transcranial alternating current stimulation (tACS); Device: sham transcranial alternating current stimulation (tACS)
Sponsors: University of North Carolina, Chapel Hill; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting -
5G-EMERALD: Amivantamab in Malignant Brain Tumours
Posted: October 9th, 2024, 11:00pm UTC
Conditions: Malignant Brain Tumors
Interventions: Drug: Amivantamab
Sponsors: Institute of Cancer Research, United Kingdom; Royal Marsden NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust; Janssen Pharmaceutica N.V., Belgium; Cancer Research UK; Minderoo Foundation; University of Cambridge
Not yet recruiting -
Effects of Oral Administration of Antrodia Cinnamomea Products for Clinical Symptoms in Spinocerebellar Ataxia Patients
Posted: October 9th, 2024, 11:00pm UTC
Conditions: Spinocerebellar Ataxia
Interventions: Dietary Supplement: Antrodia cinnamomea Products; Dietary Supplement: Antrodia cinnamomea Products
Sponsors: ALPS Biotech CO. LTD
Recruiting -
Use of Shear Wave Elastography for Intraoperative Brain and Glioma Stiffness Measurements
Posted: October 8th, 2024, 11:00pm UTC
Conditions: Glioma; Recurrent Glioma
Interventions: Other: Non-Interventional Study
Sponsors: Mayo Clinic
Not yet recruiting -
5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours
Posted: October 7th, 2024, 11:00pm UTC
Conditions: Maligrant Primary Gliomas; Glioblastoma Multiforme (GBM); Glioblastoma Multiform (Grade IV Astrocytoma); Diffuse Hemispheric Glioma, H3 G34-Mutant
Interventions: Drug: Avutometinib; Drug: Defactinib; Drug: Temozolomide
Sponsors: Institute of Cancer Research, United Kingdom; Minderoo Foundation; Verastem, Inc.; Royal Marsden NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust; Cancer Research UK; University of Cambridge
Recruiting -
Clinical Trial to Evaluate the Effects of Letermovir Prophylaxis on T-cell Immune Activation in Participants With Treated HIV-1 Infection
Posted: October 4th, 2024, 11:00pm UTC
Conditions: HIV
Interventions: Drug: Letermovir
Sponsors: University College, London; Royal Free Hospital NHS Foundation Trust
Not yet recruiting -
Key Longitudinal Associations With Risk and Glioblastoma Outcomes
Posted: October 3rd, 2024, 11:00pm UTC
Conditions: Glioblastoma
Sponsors: Duke University; Glioblastoma Research Organization; StacheStrong
Not yet recruiting -
Atovaquone Combined with Radiation in Children with Malignant Brain Tumors
Posted: October 3rd, 2024, 11:00pm UTC
Conditions: High-grade Glioma; Medulloblastoma; Diffuse Intrinsic Pontine Glioma; Diffuse Midline Glioma, H3 K27M-Mutant
Interventions: Drug: Atovaquone; Radiation: Radiation Therapy
Sponsors: Emory University; Morningside Foundation/Peach Bowl LegACy Fund
Recruiting -
High-dose Chemotherapy with Thiotepa, Busulfan, and Cyclophosphamide Followed by Autologous Stem Cell Transplantation in Central Nervous System Lymphoma
Posted: October 3rd, 2024, 11:00pm UTC
Conditions: Central Nervous System Lymphoma
Interventions: Drug: Thiotepa in conditioning before transplantation
Sponsors: Seoul National University Hospital
Terminated -
Extensive Resection of Malignant Brain Tumors Using Advanced Imaging Techniques
Posted: October 2nd, 2024, 11:00pm UTC
Conditions: Glioblastoma; Astrocytoma, IDH-Mutant, Grade 4
Interventions: Procedure: Multimodal image-guided resection
Sponsors: Amsterdam UMC, location VUmc
Recruiting -
Dietary Restriction to Prevent Cardiotoxicity in Breast Cancer Patients
Posted: October 2nd, 2024, 11:00pm UTC
Conditions: Cardiotoxicity; Breast Cancer
Interventions: Other: Protein- and Calorie restriction
Sponsors: Erasmus Medical Center
Recruiting -
The Clinical Study of the Treatment of Patients With Type I Neurofibromatosis With Smetinib Hydrosulfate Capsule
Posted: October 1st, 2024, 11:00pm UTC
Conditions: Neurofibromatosis 1
Interventions: Drug: Selumetinib
Sponsors: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Not yet recruiting -
NEUROmuscular Training for Enhanced AGE Longevity
Posted: October 1st, 2024, 11:00pm UTC
Conditions: Aging; Physical Activity; Training
Interventions: Dietary Supplement: Water-based power resistance training + Dietary supplement I (WPowDSI); Dietary Supplement: Water-based power resistance training + Placebo (WPowPl); Dietary Supplement: Elastic band-based power resistance training + Dietary supplement I (EBPowDSI); Dietary Supplement: Elastic band-based power resistance training + Placebo (EBPowPl); Dietary Supplement: Elastic band-based eccentric resistance training + Dietary supplement II (EBEccDSII); Dietary Supplement: Elastic band-based eccentric resistance training + Placebo (EBEccPl); Dietary Supplement: Elastic band-based maximum strength resistance training + Dietary supplement II (EBMaxDSII); Dietary Supplement: Elastic band-based maximum strength resistance training + Placebo (EBMaxPl); Dietary Supplement: Control + Placebo (CPl); Dietary Supplement: Control + Dietary supplement I (CDSI); Dietary Supplement: Control + Dietary supplement (CDSII); Dietary Supplement: Active Comparator: Aerobic training + Placebo (AerPl)
Sponsors: University of Valencia; Generalitat Valenciana; Indiex Sport Nutrition Spail SL
Active, not recruiting -
Impact of IDH Mutation and Adjuvant Chemo(radio)therapy on Survival Outcome in Grade II/III Astrocytoma
Posted: October 1st, 2024, 11:00pm UTC
Conditions: Astrocytoma; Astrocytic Tumors; Astrocytoma of Brain
Interventions: Other: IDH mutant-type; Other: IDH wild-type
Sponsors: asmaa salama ibrahim
Completed -
Transnasal Sphenopalatine Ganglion Block for Treatment of Acute Subarachnoid Hemorrhage Associated Headache
Posted: October 1st, 2024, 11:00pm UTC
Conditions: SAH (Subarachnoid Hemorrhage); Headache
Interventions: Combination Product: Transnasal sphenopalatine ganglion block
Sponsors: University of California, Davis; Agnes Marshall Walker Foundation
Not yet recruiting -
Trial for Local Ablative Treatment (LAT) Optimization in Patients With Advanced Non-Small Cells Lung Cancer (NSCLC) Presenting an Anaplastic Lymphoma Kinase (ALK) Rearrangement Treated by Brigatinib
Posted: October 1st, 2024, 11:00pm UTC
Conditions: NSCLC
Interventions: Biological: Blood samples for Hematology; Biological: Blood samples for Chemistry; Biological: Blood sample for liver function tests; Biological: Pregnancy test; Procedure: Tumour assessment; Procedure: Local Ablative Therapy (LAT)
Sponsors: Groupe Francais De Pneumo-Cancerologie
Not yet recruiting -
Ex Vivo Drug Response Evaluation for Next Generation Care of Brain Metastases
Posted: October 1st, 2024, 11:00pm UTC
Conditions: Brain Metastases; Brain Metastases, Adult
Interventions: Device: Pharmacoscopy 1.0; Other: Control
Sponsors: University of Zurich
Not yet recruiting -
Mapping the Effect of (neuro)inflammation on Stress Sensitivity in the Brain of Healthy Men
Posted: October 1st, 2024, 11:00pm UTC
Conditions: Inflammation; Stress; Healthy Volunteer
Interventions: Biological: Lipopolysaccharide (LPS); Other: Placebo
Sponsors: Universitaire Ziekenhuizen KU Leuven
Recruiting -
Brain Irradiation for Childhood Cancer - Endocrine Monitoring During the First Years
Posted: September 30th, 2024, 11:00pm UTC
Conditions: Endocrine; Deficiency; Hypothalamo-Pituitary Disorder; Radiotherapy Side Effect
Interventions: Radiation: Blood sample, urine sample, osteodensitometry
Sponsors: University Hospital, Angers
Not yet recruiting -
Prognostic IntraOperative Biomarkers IdeNtification in Tumor RElatEd SuRgery
Posted: September 27th, 2024, 11:00pm UTC
Conditions: Glioma; Glioblastoma (GBM); Brain Tumor-Glioma
Interventions: Device: Neuropixel probe recording
Sponsors: Erasmus Medical Center
Not yet recruiting -
Long-Term Follow-Up of Subjects Treated With AXO-AAV-GM2 for Tay-Sachs or Sandhoff Disease
Posted: September 26th, 2024, 11:00pm UTC
Conditions: GM2 Gangliosidosis; Tay Sachs Disease; Sandhoff Disease
Interventions: Drug: AXO-AAV-GM2
Sponsors: Terence Flotte
Active, not recruiting -
A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant Glioma
Posted: September 26th, 2024, 11:00pm UTC
Conditions: Glioblastoma; Glioblastoma (GBM); Astrocytoma; Astrocytoma, Grade III; Astrocytoma, Grade IV; Gliosarcoma, Adult; Gliosarcoma of Brain
Interventions: Drug: C134; Drug: C134
Sponsors: James Markert, MD
Not yet recruiting -
Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma
Posted: September 26th, 2024, 11:00pm UTC
Conditions: Glioblastoma; Recurrent Glioblastoma; Glioblastoma Multiforme of Brain
Interventions: Drug: Fluciclovine F18
Sponsors: Abramson Cancer Center at Penn Medicine
Not yet recruiting -
Tumor Absorbed Dose-Response Relationship in Patients Treated With 177Lu-DOTATATE for Meningioma
Posted: September 26th, 2024, 11:00pm UTC
Conditions: Meningioma of Brain
Interventions: Diagnostic Test: tumoral dosimetry by scintigraphy
Sponsors: Central Hospital, Nancy, France
Not yet recruiting -
Third-generation EGFR-TKI Treatment in Metastatic EGFR-mutant NSCLC: a Prospective, Observational Study
Posted: September 26th, 2024, 11:00pm UTC
Conditions: Third-generation TKI; NSCLC (Advanced Non-small Cell Lung Cancer)
Interventions: Drug: third-generation EGFR-TKI (Osimertinib, Almonertinib or Furmonertinib)
Sponsors: Fudan University
Completed -
Antirotinib Hydrochloride Plus Whole Brain Radiotherapy for Small Cell Lung Cancer With Brain Metastases
Posted: September 25th, 2024, 11:00pm UTC
Conditions: Whole Brain Radiotherapy
Interventions: Drug: Antirotinib hydrochloride
Sponsors: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Active, not recruiting -
Feasibility of CSF and Plasma ctDNA in BRAF-altered Glioma During Treatment With Plixorafenib
Posted: September 24th, 2024, 11:00pm UTC
Conditions: BRAF V600E Mutation
Interventions: Drug: Plixorafenib
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Fore Biotherapeutics; Ivy Brain Tumor Foundation
Not yet recruiting -
Cardiovascular Multimodality Imaging Study
Posted: September 24th, 2024, 11:00pm UTC
Conditions: Non-ischemic Cardiomyopathy; Cardiomyopathies; Hypertrophic Cardiomyopathy; Right Ventricular Arrhythmogenic Cardiomyopathy; Cardiac Amyloidosis; Anderson Fabry Disease; Sarcoidosis; Cancer Therapy-related Cardiac Dysfunction; Ventricular Arrythmia; Heart Failure
Sponsors: Montefiore Medical Center
Not yet recruiting -
BEAT-Breast: A Pilot Non-randomised Single Arm Phase 2 Trial of DE-iPTV in Patients With Primary Breast Cancer With Brain Metastases Who Are Not Suitable for Stereotactic Radiotherapy.
Posted: September 24th, 2024, 11:00pm UTC
Conditions: Brain Metastases, Adult; Breast Cancer
Interventions: Radiation: DE-iPTV
Sponsors: Imperial College London; University of Leicester; Centro Nacional de Investigaciones Oncologicas CARLOS III; East and North Hertfordshire NHS Trust; Norfolk and Norwich University Hospitals NHS Foundation Trust; Imperial College Healthcare NHS Trust
Not yet recruiting -
Acromegaly Resistant to Conventional Dose of First Generation Somatostatin Ligands
Posted: September 23rd, 2024, 11:00pm UTC
Conditions: Acromegaly
Interventions: Drug: Lanreotide autogel
Sponsors: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Completed -
Opioid-free Anesthesia Protocol for Neurosurgical Supratentorial Tumor Resection
Posted: September 23rd, 2024, 11:00pm UTC
Conditions: Supratentorial Tumors
Interventions: Drug: the opioid-based control group; Drug: the opioid-free anesthesia group
Sponsors: Beijing Tiantan Hospital
Not yet recruiting -
ENDO-BRAIN: Effects of Endocrine Adjuvant Therapy with Aromatase Inhibitors on the Cognitive Function of Breast Cancer Patients
Posted: September 23rd, 2024, 11:00pm UTC
Conditions: Cognitive Side Effects of Cancer Therapy; Hypoestrogenism
Interventions: Diagnostic Test: validated questionnaires; Diagnostic Test: functional MRI; Diagnostic Test: Optical Coherent Tomography Angiography
Sponsors: Ospedale Policlinico San Martino; University of Genova
Recruiting -
Loncastuximab Tesirine and Rituximab Following Stereotactic Radiosurgery (SRS) in Patients With Primary and Secondary Central Nervous System Lymphomas (Lonca-R After SRS in CNSL)
Posted: September 23rd, 2024, 11:00pm UTC
Conditions: Central Nervous System Lymphoma
Interventions: Drug: Loncastuximab tesirine and rituximab (Lonca-R)
Sponsors: University of Utah; ADC Therapeutics S.A.
Not yet recruiting -
Inflammatory Markers (ICC, MCVL) and Nivolumab Response: Predicting Immunotherapy Success in Metastatic RCC
Posted: September 23rd, 2024, 11:00pm UTC
Conditions: Metastatic Renal Cell Carcinoma
Sponsors: Dr. Lutfi Kirdar Kartal Training and Research Hospital
Completed -
Ketamine, SGB and Combination Treatment for TBI
Posted: September 23rd, 2024, 11:00pm UTC
Conditions: Posttraumatic Headache; Posttraumatic Stress Disorder
Interventions: Procedure: Group A active comparator; Drug: Group B active comparator; Combination Product: Group C Experimental; Other: Group D Placebo Comparator
Sponsors: Northwestern University; Walter Reed National Military Medical Center; Lviv National Medical University
Not yet recruiting -
Development and Validation of the FBIndex to Determine the Risk of Falls for Patients with Neuromuscular Disorders
Posted: September 20th, 2024, 11:00pm UTC
Conditions: Inclusion Body Myositis; Myotonic Dystrophy; Limb-girdle and Facioscapulohumeral Muscular Dystrophies; Pompe Disease; Myasthenia Gravis; Lambert-Eaton-Syndrome; Amyotrophic Lateral Sclerosis; Spinal Muscular Atrophy; Guillain-Barré Syndrome; Chronic Inflammatory Demyelinating Polyneuropathy; Friedreich Ataxia; Hereditary Motor Sensory Neuropathy
Sponsors: LMU Klinikum
Enrolling by invitation -
Arginin-stimulated Copeptin in Polyuria-polydipsia Syndrome in Children
Posted: September 20th, 2024, 11:00pm UTC
Conditions: Primary Polydipsia; Central Diabetes Insipidus; Nephrogenic Diabetes Insipidus
Interventions: Procedure: Measure of Basal Copeptin level; Procedure: Measure of arginine-stimulated copeptin; Procedure: IRM; Behavioral: Water reduction at home
Sponsors: Assistance Publique Hopitaux De Marseille
Not yet recruiting -
AI-guided Prognostication and Cranial Radiotherapy Optimization in EGFR-TKI-treated Non-small Cell Lung Cancer Patients With Baseline Brain Metastases
Posted: September 19th, 2024, 11:00pm UTC
Conditions: NSCLC (Advanced Non-small Cell Lung Cancer); Brain Metastasases
Interventions: Drug: third-generation EGFR TKIs (Almonertinib/Furmonertinib/Osimertinib)
Sponsors: Fudan University
Not yet recruiting -
A Single-arm, Prospective Phase â…¡ Clinical Study of Utidelone Combined with Capecitabine in the Treatment of Active Brain Metastasis of TNBC
Posted: September 19th, 2024, 11:00pm UTC
Conditions: Metastatic Breast Cancer
Interventions: Drug: Utidelone and capecitabine
Sponsors: Henan Cancer Hospital
Recruiting -
Secondary Prevention of VTE in Patients with Cancer and Catheter-Related Upper Extremity Deep Vein Thrombosis
Posted: September 19th, 2024, 11:00pm UTC
Conditions: Venous Thromboembolism; Cancer; Upper Extremity Deep Vein Thrombosis; Catheter-Related Infections
Interventions: Drug: Apixaban
Sponsors: Ottawa Hospital Research Institute
Not yet recruiting -
TMLI/Fludarabine/Melphalan Conditioning for Allogeneic Transplantation in High-risk Myelodysplastic Syndrome or Acute Myeloid Leukemia.
Posted: September 19th, 2024, 11:00pm UTC
Conditions: Myelodysplastic Syndromes; Acute Myeloid Leukemia
Interventions: Combination Product: TMLI/Flu/Mel
Sponsors: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Not yet recruiting -
Irradiation in Paediatrics: Neurocognition, Neuroimaging and Evaluation of Memory and Attention
Posted: September 19th, 2024, 11:00pm UTC
Conditions: Brain Tumor, Pediatric
Interventions: Other: Neuropsychological assessments:
Sponsors: Institut Claudius Regaud
Not yet recruiting -
Early Application of Memantine and Pioglitazone to Protect Cognitive Function After Radiotherapy
Posted: September 13th, 2024, 11:00pm UTC
Conditions: Radiation Disease; Cognitive Impairment; Drug Effect
Interventions: Drug: Memantine Oral Tablet; Drug: Pioglitazone 15mg; Radiation: Hippocampal avoidance whole-brain radiotherapy (HA-WBRT)
Sponsors: Affiliated Cancer Hospital & Institute of Guangzhou Medical University; Guangdong Provincial People's Hospital; Fujian Medical University Union Hospital; Southern Medical University, China; The Affiliated Panyu Center Hospital of Guangzhou Medical University; The Central Hospital of Shaoyang City
Not yet recruiting -
Fluid Responsiveness in Posterior Fossa Tumor Resection: PPV and CVP Guidance
Posted: September 13th, 2024, 11:00pm UTC
Conditions: Posterior Fossa Tumor; Brain Tumor Adult
Interventions: Procedure: Pulse pressure variation; Procedure: Central venous pressure
Sponsors: Chiang Mai University
Active, not recruiting -
Observational Study on Characteristics and Survival Correlates of Progressive Multifocal Leukoencephalopathy (PML) in Italy
Posted: September 13th, 2024, 11:00pm UTC
Conditions: Progressive Multifocal Leukoencephalopathy; PML
Sponsors: Scientific Institute San Raffaele
Completed -
Postoperative Complications Following Skull Base Tumor Resection
Posted: September 9th, 2024, 11:00pm UTC
Conditions: Skull Base Tumor; Postoperative Complications
Interventions: Other: Pulmonary ultrasound examination
Sponsors: Beijing Tiantan Hospital
Not yet recruiting -
A Real-world Study to Assess the Use of Siponimod in Spain to Treat Patients With Secondary Progressive Multiple Sclerosis
Posted: September 9th, 2024, 11:00pm UTC
Conditions: Secondary Progressive Multiple Sclerosis
Sponsors: Novartis
Completed -
JK-1201I in Triple Negative Breast Cancer Patients with Brain Metastases
Posted: September 6th, 2024, 11:00pm UTC
Conditions: Triple Negative Breast Cancer (TNBC); Brain Metastasases
Interventions: Drug: JK-1201I
Sponsors: JenKem Technology Co., Ltd.
Not yet recruiting -
Molecular Pituitary Imaging Using 18F-FET PET
Posted: September 4th, 2024, 11:00pm UTC
Conditions: Pituitary Adenoma
Interventions: Diagnostic Test: 18F-Fluoro-ethyl-tyrosine (FET) PET
Sponsors: University of Cambridge; Cambridge University Hospitals NHS Foundation Trust
Not yet recruiting -
Quest to Analyze One Thousand Humans Meditating
Posted: September 4th, 2024, 11:00pm UTC
Conditions: Amyotrophic Lateral Sclerosis (ALS); Angina, Stable; Anxiety; Asthma; Atrial Fibrillation; Cancer Brain; Cancer, Breast; Cancer Colon; Cancer, Lung; Cancer, Ovarian; Cancer Prostate; Cancer Skin; Throat Cancer; Lymphoma; Cancer, Thyroid; Cancer, Other; Cerebral Palsy; Chronic Fatigue Syndrome; Cluster Headache; Chronic Obstructive Pulmonary Disease (COPD); Chronic Kidney Diseases; Crohn Disease; Deafness; Depression; Diabetes; Eczema; Epilepsy; Fibroids; Fibromyalgia; Heart Failure; Hypertension; Hyperthyroidism; Hypothyroidism; Irritable Bowel Syndrome (IBS); Infertility; Lyme Disease; Macular Degeneration; Migraine; Multiple Allergies; Multiple Sclerosis; Osteoarthritis; Osteoporosis; Ovarian Cysts; Parkinson Disease; Phantom Limb Pain; Psoriasis; Post Traumatic Stress Disorder (PTSD); Rheumatoid Arthritis; Sjogrens Disease; Spinal Cord Injury; Spinal Stenosis; Stroke; Tension Headache; Tinnitus; Ulcerative Colitis
Interventions: Behavioral: Advanced multi-component meditation practice
Sponsors: Tobias Moeller-Bertram; Metamorphosis, LLC; University of California, San Diego
Enrolling by invitation -
Emulation of the Moderate Alcohol and Cardiovascular Health Trial (MACH15)
Posted: September 3rd, 2024, 11:00pm UTC
Conditions: Myocardial Infarction; Ischemic Stroke; Angina Pectoris; Coronary Revascularization; All-cause Mortality; Cardiovascular Death; Type 2 Diabetes; Heart Failure; Atrial Fibrillation; Cancer; Dementia; Depression; Infections; Injuries; Liver Cirrhosis
Interventions: Behavioral: Moderate drinking; Behavioral: Quitting; Behavioral: Social drinking; Behavioral: Heavy/binge drinking
Sponsors: Harvard School of Public Health (HSPH)
Completed -
Stop Addiction Stigma
Posted: September 2nd, 2024, 11:00pm UTC
Conditions: Hematopoietic and Lymphatic System Neoplasm; Malignant Solid Neoplasm
Interventions: Behavioral: Assessment; Other: Educational Activity; Other: Educational Activity; Other: Educational Activity; Other: Educational Activity; Other: Educational Activity; Other: Educational Activity; Other: Training
Sponsors: Ohio State University Comprehensive Cancer Center
Completed -
Elimination of PTV Margins Based on MRI-guided Adaptive Stereotactic Radiotherapy for Non-small Cell Lung Cancer With Brain Metastasis
Posted: September 2nd, 2024, 11:00pm UTC
Conditions: MRI-guided Adaptive Radiotherapy; Non-small Cell Lung Cancer; Brain Metastasis
Interventions: Radiation: MRI-guided adaptive SRT; Radiation: Conventional SRT
Sponsors: Sun Yat-sen University
Recruiting -
Enhanced Assistance During Radiotherapy for Unmet Essential Needs
Posted: September 2nd, 2024, 11:00pm UTC
Conditions: Bone Cancer; Brain Cancer; Colorectal Cancer; Esophagus Cancer; Lymphoma; Salivary Gland Cancer; Head and Neck Cancer; Liver Cancer; Ovarian Cancer; Pancreatic Cancer; Prostate Cancer; Small Intestine Cancer; Stomach Cancer; Urinary Bladder Cancer; Anal Cancer; Blood Cancer; Breast Cancer; Cervical Cancer; Lung Cancer; Kidney Cancer; Penile Cancer; Skin Cancer; Testicular Cancer; Thyroid Cancer; Uterine Cancer; Vaginal Cancer; Vulvar Cancer
Interventions: Other: Standard assistance; Other: Enhanced assistance
Sponsors: Washington University School of Medicine; American Society of Clinical Oncology
Recruiting -
Repurposing Riluzole for Cancer-Related Cognitive Impairment: a Pilot Trial
Posted: August 30th, 2024, 11:00pm UTC
Conditions: Breast Cancer
Interventions: Drug: Riluzole; Drug: Placebo
Sponsors: University of California, Irvine
Not yet recruiting -
Effects of Thai Dance Meditation Exercise on Renal and Cerebrovascular Function in Elderly With Diabetic Kidney Disease
Posted: August 29th, 2024, 11:00pm UTC
Conditions: Diabetic Kidney Disease
Interventions: Other: Thai dance meditation; Other: No intervention
Sponsors: Chulalongkorn University
Completed -
Using the Chemical Modifications Present on RNA Molecules to Diagnose and Treat Brain Cancer
Posted: August 28th, 2024, 11:00pm UTC
Conditions: Glioma
Interventions: Diagnostic Test: Blood, urine and tumoral tissue samples; Diagnostic Test: Tumoral tissue samples
Sponsors: Institut du Cancer de Montpellier - Val d'Aurelle; National Cancer Institute, France
Not yet recruiting -
Relationships of Affect and Neuroinflammation With Clinical Pain in Veterans With Fibromyalgia
Posted: August 27th, 2024, 11:00pm UTC
Conditions: Fibromyalgia
Interventions: Behavioral: Moderate Intensity Continuous Training
Sponsors: VA Office of Research and Development
Not yet recruiting -
USPIO Enhanced MR Imaging in CNS Tumours (UMIC)
Posted: August 27th, 2024, 11:00pm UTC
Conditions: Vestibular Schwannoma; Glioma, Astrocytic
Interventions: Diagnostic Test: USPIO enhanced MRI
Sponsors: Northern Care Alliance NHS Foundation Trust
Recruiting -
Institutional Registry of Rare Diseases
Posted: August 27th, 2024, 11:00pm UTC
Conditions: Rare Diseases; Amyloidosis; Sarcoidosis; Phacomatosis; Pheochromocytoma; Paraganglioma; Von Hippel-Lindau Disease; Immunoglobulin G4-Related Disease; Demyelinating Diseases; Inborn Errors of Metabolism; Eosinophilic Gastrointestinal Disorders; Hypertrophic Cardiomyopathy; Gaucher Disease; Congenital Adrenal Hyperplasia; Hereditary Angioedema; Pulmonary Hypertension; Wilson Disease; Vascular Anomalies; Mastocytosis; Multiple Endocrine Neoplasia; Inflammatory Bowel Diseases; Prader-Willi Syndrome; Hirschsprung Disease; Cushing Syndrome
Sponsors: Hospital Italiano de Buenos Aires
Recruiting -
Use of a Cannabinoids as a Treatment Strategy for Alzheimer's Disease
Posted: August 26th, 2024, 11:00pm UTC
Conditions: Alzheimer Disease
Interventions: Other: Cannabis; Other: Placebo
Sponsors: Federal University of Latin American Integration
Recruiting -
Reinforcement Learning and Obsessive-compulsive Disorder: Exploring the Role of the Orbitofrontal Cortex
Posted: August 22nd, 2024, 11:00pm UTC
Conditions: Obsessive-Compulsive Disorder
Sponsors: Fundacao Champalimaud
Recruiting -
A Real-World Comparative Study of Donanemab (LY3002813) Plus Usual Care Versus Usual Care Alone in US Participants With Early Symptomatic Alzheimer's Disease
Posted: August 22nd, 2024, 11:00pm UTC
Conditions: Alzheimer Disease
Interventions: Drug: Donanemab; Drug: Usual Care
Sponsors: Eli Lilly and Company
Not yet recruiting -
The Safety and Efficacy of Rapamycin on Communicating Hydrocephalus Secondary to Intraventricular Hemorrhage
Posted: August 21st, 2024, 11:00pm UTC
Conditions: Communicating Hydrocephalus; Cerebral Intraventricular Hemorrhage; Secondary Normal Pressure Hydrocephalus; Post Hemorrhagic Hydrocephalus
Interventions: Drug: Rapamycin
Sponsors: Beijing Tiantan Hospital
Recruiting -
18F-FET PET/CT in the Management of Glioma
Posted: August 20th, 2024, 11:00pm UTC
Conditions: Glioma
Interventions: Device: 18F-FET PET/CT
Sponsors: Buddhist Tzu Chi General Hospital
Completed -
Ibrutinib and Acalabrutinib Use and Risk of Atrial Fibrillation in Patients With Chronic B-cell Malignancies
Posted: August 20th, 2024, 11:00pm UTC
Conditions: Chronic B-cell Malignancies; BTK Inhibitors; Cardiovascular Diseases
Interventions: Drug: BTK inhibitor (Ibrutinib or Acalabrutinib)
Sponsors: University Hospital, Caen
Active, not recruiting -
Clinical Study on the Safety and Efficacy of Novel Oncolytic Virus in the Treatment of Recurrent Malignant Glioma
Posted: August 20th, 2024, 11:00pm UTC
Conditions: Glioblastoma Multiforme; Gliomas, Malignant
Interventions: Biological: ON-01; Drug: ONF
Sponsors: Beijing Neurosurgical Institute
Completed -
Testing a Brief Exercise Intervention in Hoarding Disorder
Posted: August 20th, 2024, 11:00pm UTC
Conditions: Hoarding Disorder
Interventions: Behavioral: Exercise Condition; Behavioral: Relaxation Control Condition
Sponsors: Hartford Hospital; University of Miami
Not yet recruiting -
Evaluation of Postoperative Intracranial Pressure in Patients Undergoing Intracranial Tumor Surgery
Posted: August 19th, 2024, 11:00pm UTC
Conditions: INTRACRANIAL TUMOR; INTRACRANIAL PRESSURE; OPTIC NERVE
Interventions: Procedure: USG; Procedure: BCT
Sponsors: Sezen KumaÅŸ Solak; Bagcilar Training and Research Hospital
Not yet recruiting -
Effectiveness of Probiotics for the Prevention of Gastrointestinal Toxicity in Children With Leukemia
Posted: August 19th, 2024, 11:00pm UTC
Conditions: Probiotics; Gastrointestinal Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Interventions: Biological: Lactobacillus casei; Biological: Lactobacillus rhamnosus; Biological: Bifidobacterium bifidum; Dietary Supplement: Placebo
Sponsors: National Institute of Pediatrics, Mexico
Not yet recruiting -
Carotid Artery Stenosis and Ischemic Cerebrovascular Events After Radiotherapy in Patients With Head and Neck Cancer
Posted: August 16th, 2024, 11:00pm UTC
Conditions: Carotid Artery Stenosis; Head and Neck Cancer; Radiation Therapy; Transient Ischemic Attack; Ischemic Stroke
Interventions: Radiation: Radiotherapy
Sponsors: Chulabhorn Royal Academy
Completed -
Study on Prevalence and Impact of Brain Metastases on Survival in Lung Cancer by Line of Treatment
Posted: August 16th, 2024, 11:00pm UTC
Conditions: Non-small Cell Lung Cancer; Lung Cancer; Metastatic Cancer; Brain and Central Nervous System Cancer
Interventions: Other: No drug
Sponsors: Daiichi Sankyo
Active, not recruiting -
Adjuvant Hypofractionated Stereotactic Radiosurgery for Intermediate-risk Meningioma
Posted: August 16th, 2024, 11:00pm UTC
Conditions: Meningioma; Meningioma, Malignant; Recurrent Meningioma
Interventions: Radiation: Hypofractionated Stereotactic Radiosurgery (SRS); Procedure: Magnetic Resonance Imaging (MRI); Procedure: Computed Tomography (CT)
Sponsors: University of California, San Francisco; American Society of Clinical Oncology
Not yet recruiting -
Hippocampus-Avoidance Whole-Brain Radiation Therapy With Simultaneous Integrated Boost for BMs of NSCLC
Posted: August 16th, 2024, 11:00pm UTC
Conditions: Brain Metastases; Non-small Cell Lung Cancer
Interventions: Radiation: ippocampus-Avoidance Whole-Brain Radiation Therapy With Simultaneous Integrated Boost
Sponsors: Yatian Liu
Completed -
Effects of HIIT on Bone Metabolism in Individuals With Chronic Stroke
Posted: August 15th, 2024, 11:00pm UTC
Conditions: Stroke; Bone Loss
Interventions: Other: High-intensity interval training group; Other: Moderate-intensity continuous training group; Other: Stretching group
Sponsors: The Hong Kong Polytechnic University
Not yet recruiting -
Surgical and Pharmacological Efficacy of Knosp Grade 0-2 Prolactinoma
Posted: August 15th, 2024, 11:00pm UTC
Conditions: Pituitary Tumor
Interventions: Procedure: Transnasal transsphenoidal pituitary lesion resection under neuroendoscopy; Drug: Bromocriptin 2.5mg, 2-3 times a day
Sponsors: Second Affiliated Hospital, School of Medicine, Zhejiang University; Peking Union Medical College Hospital; West China Hospital; First Affiliated Hospital of Wenzhou Medical University; Ningbo Medical Center Lihuili Hospital
Not yet recruiting -
RESET-BRAIN: REhabilitation of SleEp and cogniTive Impairment in BReast Cancer Survivors Using an App-based Intervention
Posted: August 14th, 2024, 11:00pm UTC
Conditions: Insomnia; Cognitive Impairment; Breast Cancer
Interventions: Behavioral: Cognitive Behavioral Therapy for Insomnia (CBT-I); Behavioral: Sleep hygiene education
Sponsors: Aarhus University Hospital; University of Aarhus
Not yet recruiting -
Selinexor With ICE Chemotherapy in Secondary Central Nervous System Involving B-cell Non-Hodgkin Lymphoma
Posted: August 14th, 2024, 11:00pm UTC
Conditions: B-cell Lymphoma Recurrent; B-cell Lymphoma Refractory; CNS Metastases
Interventions: Drug: Selinexor
Sponsors: Samsung Medical Center; Korean Society of Hematology
Recruiting -
Acupuncture Reduces Relapse in Patients With Crohn's Disease: a Superiority Trial
Posted: August 14th, 2024, 11:00pm UTC
Conditions: Crohn's Disease Relapse; Inflammatory Bowel Diseases
Interventions: Other: "Harmonizing Shaoyang, nourishing spleen and kidney with warmth" Acupuncture Group; Other: "Nourishing spleen and kidney with warmth" Acupuncture Group
Sponsors: Shanghai Institute of Acupuncture, Moxibustion and Meridian; Ruijin Hospital
Recruiting -
The Effect of Cancer Treatments on Speech Perception in Noise, Cognition, and Hearing-Related Quality of Life
Posted: August 13th, 2024, 11:00pm UTC
Conditions: Cancer; Hearing Loss Ototoxic; Cognitive Decline; Quality of Life
Interventions: Other: Chemotherapy, chemoradiation, radiation therapy
Sponsors: Turku University Hospital
Not yet recruiting -
A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma
Posted: August 13th, 2024, 11:00pm UTC
Conditions: Glioblastoma; Recurrent Glioblastoma; Brain Tumor
Interventions: Drug: Troriluzole
Sponsors: Eudocia Quant Lee, MD; National Institutes of Health (NIH); Biohaven Pharmaceuticals, Inc.
Not yet recruiting -
Phase II Efficacy Study of Repotrectinib in Frail and/or Elderly Patients With ROS1-rearranged Advanced NSCLC
Posted: August 13th, 2024, 11:00pm UTC
Conditions: NSCLC Stage IV; NSCLC, Stage III
Interventions: Drug: Repotrectinib
Sponsors: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer; Groupe Français de Pneumo-Cancérologie; Hospices Civils de Lyon
Not yet recruiting -
Real-life Second-line Epirubicin-Paclitaxel Regimen as Treatment of Relapsed Small-Cell Lung Cancer : EpiTax Study.
Posted: August 13th, 2024, 11:00pm UTC
Conditions: Advanced Small Cell Lung Carcinoma
Sponsors: University Hospital, Brest
Completed -
Radioimmunotherapy in Solid Tumors (PNRR-MCNT2-2023-12378239-Aim2)
Posted: August 13th, 2024, 11:00pm UTC
Conditions: Glioblastoma
Interventions: Radiation: Neoaddjuvant Stereotactic Radiotherapy with Simultaneous Integrated Boost
Sponsors: IRCCS San Raffaele; European Commission; Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale; Azienda Ospedaliera di Rilievo Nazionale e di Alta Specialità San Giuseppe Moscati (Avellino)
Not yet recruiting -
Clinical Outcomes Following Primary Intracerebral Hemorrhage
Posted: August 12th, 2024, 11:00pm UTC
Conditions: Stroke; Intracerebral Hemorrhage
Sponsors: Second Affiliated Hospital, School of Medicine, Zhejiang University; The People's Hospital of Haiyan; Taizhou First People's Hospital; The First People's Hospital of Pinghu; The 2nd People's Hospital of Quzhou
Recruiting -
Investigating Mechanistic Predictors of Interpatient Variability and Temozolomide (TMZ) Induced Haematological Toxicity for Glioma Patients
Posted: August 9th, 2024, 11:00pm UTC
Conditions: Glioma
Sponsors: University College Cork; University Hospital Waterford
Recruiting -
Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Methotrexate in Breast Cancer With Leptomeningeal Metastasis
Posted: August 8th, 2024, 11:00pm UTC
Conditions: Leptomeningeal Metastasis of Breast Cancer
Interventions: Drug: Intrathecal Administration of Thiotepa in Combination with Methotrexate via the Ommaya Reservoir
Sponsors: The First Affiliated Hospital with Nanjing Medical University; The Affiliated Brain Hospital of Nanjing Medical University
Recruiting -
Multicentre Clinical Study of Ultra-Fast-Track Anaesthesia for Minimally Invasive Heart Valve Surgery
Posted: August 7th, 2024, 11:00pm UTC
Conditions: Heart Valve Diseases; Enhanced Recovery After Surgery
Interventions: Procedure: Ultra-Fast-Track Cardiac Anesthesia(UFTCA); Procedure: conventional general anesthesia (CGA)
Sponsors: Zhejiang Provincial People's Hospital; Beijing Anzhen Hospital; Fudan University; Wuhan Asia Heart Hospital; Tianjin Chest Hospital; Chinese PLA General Hospital; First Affiliated Hospital Xi'an Jiaotong University; Xiangya Hospital of Central South University; The Fourth Affiliated Hospital of Zhejiang University School of Medicine; Guangdong Provincial People's Hospital
Not yet recruiting -
FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases
Posted: August 6th, 2024, 11:00pm UTC
Conditions: Alpha-Thalassemia; Beta-Thalassemia; Amyloidosis; Amyotrophic Lateral Sclerosis; Creutzfeld-Jakob Disease; Cystic Fibrosis; Duchenne Muscular Dystrophy; Early-Onset Alzheimer Disease; Ehlers-Danlos Syndrome; Huntington Disease; Gaucher Disease; GM1 Gangliosidosis; Myasthenia Gravis; Pompe Disease; Sickle Cell Disease; Transthyretin Amyloid Cardiomyopathy; Rare Diseases
Sponsors: xCures
Recruiting -
Efficacy, Safety and Neural Mechanism of Stellate Ganglion Block in the Treatment of Anxiety. Disorder.
Posted: August 6th, 2024, 11:00pm UTC
Conditions: Anxiety Disorders; Stellate Ganglion Block
Interventions: Other: Stellate Ganglion Block
Sponsors: Nanjing Medical University
Not yet recruiting -
Low-Intensity Oscillatory Magnetic Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme (GBM) - An Exposure-time Escalation Pilot Trial
Posted: August 1st, 2024, 11:00pm UTC
Conditions: Glioblastoma Multiforme
Interventions: Device: Oncomagnetic device
Sponsors: BioTex, Inc.
Not yet recruiting