This case provides a rare example of a toxic chain of events initiated by uncontrolled blood sugar. The patient's hyperglycemia results in diabetic ketoacidosis ...
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Google - Acinar Cell Carcinoma
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Case Report: 'Toxic Cascade' of DKA and Hypertriglyceridemia - MedPage Today
Posted: December 10th, 2018, 6:00am GMT
Case Report: 'Toxic Cascade' of DKA and Hypertriglyceridemia MedPage Today -
Alcohol Abuse: Complications and Consequences - Medscape
Posted: December 6th, 2018, 4:06am GMT
Alcohol Abuse: Complications and Consequences MedscapePeople who chronically abuse alcohol are at increased risk for cirrhosis, GI bleeding, pancreatitis, cardiomyopathy, trauma, mental health disorders, and a wide ...
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Best Agents Should Be Used Upfront for the Treatment of NSCLC, Levy Says - Targeted Oncology
Posted: December 4th, 2018, 6:00am GMT
Best Agents Should Be Used Upfront for the Treatment of NSCLC, Levy Says Targeted OncologyDuring a Targeted Oncology case-based peer perspectives program, Benjamin P. Levy, MD, discussed his clinical considerations for the management of ...
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Dad-of-three given months to live after being struck down with an incurable form of cancer - Wales Online
Posted: November 11th, 2018, 6:00am GMT
Dad-of-three given months to live after being struck down with an incurable form of cancer Wales OnlineMore than £30000 has been raised for Brian Farrell who wants to spend as much time as he can with his wife and children.
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Rare Prostate Cancer Associated with Cushing’s Syndrome in Case Report - Cushing's Disease News
Posted: October 16th, 2018, 5:00am GMT
Rare Prostate Cancer Associated with Cushing’s Syndrome in Case Report Cushing's Disease NewsA patient with depression developed Cushing's syndrome (CS) because of a rare ACTH-secreting small cell cancer of the prostate, a case study reports.
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This RSS feed URL is deprecated
Posted: August 30th, 2018, 5:00am GMT
This RSS feed URL is deprecated, please update. New URLs can be found in the footers at [https:] -
Phosphatidylinositol Biphosphate (PIP2) Signal Pathway - News-Medical.net
Posted: August 23rd, 2018, 5:00am GMT
Phosphatidylinositol Biphosphate (PIP2) Signal Pathway News-Medical.netBy Jeyashree Sundaram, MBA. Phosphatidylinositol 4,5-bisphosphate (PIP2) is an essential lipid involved in metabolic processes. It is integral to the cell ...
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lobular breast carcinoma in situ child sexual abuse poems - French Tribune
Posted: August 12th, 2018, 8:16pm GMT
lobular breast carcinoma in situ child sexual abuse poems
French Tribune
lobular breast carcinoma in situ. Lobular carcinoma healing from sexual abuse poems in situ lcis is an incidental microscopic finding with characteristic cellular morphology and multifocal tissue patterns.The condition is a laboratory diagnosis and ... -
Microcalcifications in Breast Cancer - News-Medical.net
Posted: August 2nd, 2018, 1:21am GMT
Microcalcifications in Breast Cancer News-Medical.netCalcifications in the breast can be benign or malignant. They can appear as either macrocalcifications or microcalcifications on a mammogram (i.e. an X-ray of ...
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FOIU 2018: Aggressive and Unusual Subtypes of Prostate Cancer - UroToday
Posted: July 5th, 2018, 5:00am GMT
FOIU 2018: Aggressive and Unusual Subtypes of Prostate Cancer UroTodayFOIU 2018 aggressive and unusual subtypes of prostate cancer, prostatic duct adenocarcinoma, Intraductal carcinoma, PC with neuroendocrine differentiation, ...
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Role of Wnt/beta-catenin signaling in hepatocellular carcinoma, pathog | JHC - Dove Medical Press
Posted: June 27th, 2018, 5:00am GMT
Role of Wnt/beta-catenin signaling in hepatocellular carcinoma, pathog | JHC Dove Medical PressRole of Wnt/beta-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance Ahmed M Khalaf,1 David Fuentes,1 Ali I Morshid,2 Mata ...
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Acinic Cell Carcinoma - News-Medical.net
Posted: June 20th, 2018, 11:28pm GMT
News-Medical.net
Acinic Cell Carcinoma
News-Medical.net
Acinic cell carcinoma is a rare cancer of the salivary glands that originates from the parotid gland. It is a low-grade salivary neoplasm that constitutes about 5% to 17% of cases involving salivary gland malignancies. In comparison with other salivary ...
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Acinic Cell Carcinoma - News-Medical.net
Posted: June 20th, 2018, 11:28pm GMT
Acinic Cell Carcinoma News-Medical.netAs salivary glands are made up of different cells, tumors could start in any one of such. Various salivary gland tumors, which may be benign or malignant, may ...
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The ABCs of veterinary dentistry: 'O' is for oral masses of the benign kind - dvm360
Posted: June 7th, 2018, 5:00am GMT
The ABCs of veterinary dentistry: 'O' is for oral masses of the benign kind dvm360A long time ago, dogs and cats roamed outside the homestead, guarding against invaders and controlling vermin. Pets were eventually invited into the home, ...
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Malignant Epithelioid Mesothelioma - Asbestos.com
Posted: May 12th, 2018, 1:52pm GMT
Malignant Epithelioid Mesothelioma
Asbestos.com
Epithelioid patients diagnosed before the cancer has spread throughout the chest often qualify for multimodal therapy, which attempts to kill cancer cells using multiple types or modes of therapy. Multimodal therapy combines the most effective ...
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Epithelioid Mesothelioma: Epithelial Cell Prognosis & Treatment - Asbestos.com
Posted: May 12th, 2018, 1:52pm GMT
Epithelioid Mesothelioma: Epithelial Cell Prognosis & Treatment Asbestos.comEpithelioid mesothelioma is the most common type of malignant mesothelioma. Patients with epithelioid cancer cells respond best to treatment.
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Hydrogel microenvironments for cancer spheroid growth and drug screening - Science Advances
Posted: April 27th, 2018, 4:09pm GMT
Hydrogel microenvironments for cancer spheroid growth and drug screening
Science Advances
Biomimetic hydrogel scaffolds for MCS growth offer a broad spectrum of biophysical and biochemical cues that help to recapitulate the behavior of natural extracellular matrix, essential for regulating cancer cell behavior. This perspective highlights ...
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Hydrogel microenvironments for cancer spheroid growth and drug screening - Science Advances
Posted: April 27th, 2018, 5:00am GMT
Hydrogel microenvironments for cancer spheroid growth and drug screening Science AdvancesMulticellular cancer spheroids (MCSs) have emerged as a promising in vitro model that replicates many features of solid tumors in vivo. Biomimetic hydrogel ...
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Injecting gene cocktail into mouse pancreas leads to human-like tumors - Science Daily
Posted: April 5th, 2018, 5:00am GMT
Injecting gene cocktail into mouse pancreas leads to human-like tumors Science DailyA researcher has invented a unique method to generate, in mice, pancreatic tumors that resemble human pancreatic cancer. This will be a tool researchers can ...
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Higher doses of radiation don't improve survival in prostate cancer - Medical Xpress
Posted: March 15th, 2018, 5:00am GMT
Higher doses of radiation don't improve survival in prostate cancer Medical XpressA new study shows that higher doses of radiation do not improve survival for many patients with prostate cancer, compared with the standard radiation treatment.
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Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors - Science
Posted: March 13th, 2018, 5:00am GMT
Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors SciencePredicting how a tumor can adapt to a drug may help identify the patients most likely to respond as well as strategies to avoid resistance. Activation of the kinase ...
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Could Cassava leaves and roots extract be the Magic cure for colon, prostate and bladder cancers? - Modern Ghana
Posted: March 2nd, 2018, 6:00am GMT
Could Cassava leaves and roots extract be the Magic cure for colon, prostate and bladder cancers? Modern GhanaGrowing up in my village called Suhum-Amanhia on the Koforidua road; I quite remembered we were told of the two main varieties of cassava: The one eatable ...
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Low-Level Endogenous PSMA Expression in Nonprostatic Tumor Xenografts Is Sufficient for In Vivo Tumor Targeting and Imaging - Journal of Nuclear Medicine
Posted: March 1st, 2018, 6:00am GMT
Low-Level Endogenous PSMA Expression in Nonprostatic Tumor Xenografts Is Sufficient for In Vivo Tumor Targeting and Imaging Journal of Nuclear Medicine+ Author Affiliations. 1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland. 2Sidney ...
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Norwich man trying to raise £70,000 for rare cancer treatment | Health - Norfolk Eastern Daily Press
Posted: February 14th, 2018, 6:00am GMT
Norwich man trying to raise £70,000 for rare cancer treatment | Health Norfolk Eastern Daily PressDamion Burbank has been diagnosed with a rare form of cancer, the family are hoping to rasie money to pay for treatments abroad. Damion at home with his ...
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Negative Repeat Biopsy in PCa Active Surveillance a Positive Sign - Renal and Urology News
Posted: February 8th, 2018, 6:00am GMT
Negative Repeat Biopsy in PCa Active Surveillance a Positive Sign Renal and Urology NewsIn a study, a negative confirmatory prostate biopsy in prostate cancer patients on active surveillance predicts a lower risk of progressing to treatment.
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Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription - Science
Posted: November 28th, 2017, 6:00am GMT
Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription ScienceOrai1 enables Ca2+ influx into cells in response to ER Ca2+ depletion, resulting in various Ca2+-dependent signaling events, including the stimulation of ...
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68Ga-PSMA-11 PET/CT Interobserver Agreement for Prostate Cancer Assessments: An International Multicenter Prospective Study - Journal of Nuclear Medicine
Posted: October 1st, 2017, 5:00am GMT
68Ga-PSMA-11 PET/CT Interobserver Agreement for Prostate Cancer Assessments: An International Multicenter Prospective Study Journal of Nuclear Medicine+ Author Affiliations. 1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California. 2Department of ...
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Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors - Am J Pathology
Posted: September 27th, 2017, 5:00am GMT
Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors Am J PathologyActivation of the phosphoinositide 3-kinase–AKT, Yes-associated protein (YAP), and MYC pathways is involved in human liver cancers, including hepatocellular ...
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Taurocholate Induces Biliary Differentiation of Liver Progenitor Cells Causing Hepatic Stellate Cell Chemotaxis in the Ductular Reaction - Am J Pathology
Posted: September 18th, 2017, 5:00am GMT
Taurocholate Induces Biliary Differentiation of Liver Progenitor Cells Causing Hepatic Stellate Cell Chemotaxis in the Ductular Reaction Am J PathologyCystic fibrosis liver disease (CFLD) in children causes progressive fibrosis leading to biliary cirrhosis; however, its cause(s) and early pathogenesis are unclear.
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A versatile 3D tissue matrix scaffold system for tumor modeling and drug screening - Science Advances
Posted: September 13th, 2017, 5:00am GMT
A versatile 3D tissue matrix scaffold system for tumor modeling and drug screening Science AdvancesMost of the anticancer drug candidates entering preclinical trials fail to be approved for clinical applications. The following are among the main causes of these ...
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In Vivo Expression of miR-32 Induces Proliferation in Prostate Epithelium - Am J Pathology
Posted: August 18th, 2017, 5:00am GMT
In Vivo Expression of miR-32 Induces Proliferation in Prostate Epithelium Am J PathologymiRNAs are important regulators of gene expression and are often deregulated in cancer. We have previously shown that miR-32 is an androgen ...
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Thyroid Hormone Receptor-β Agonist GC-1 Inhibits Met-β-Catenin–Driven Hepatocellular Cancer - Am J Pathology
Posted: August 11th, 2017, 5:00am GMT
Thyroid Hormone Receptor-β Agonist GC-1 Inhibits Met-β-Catenin–Driven Hepatocellular Cancer Am J PathologyThe thyromimetic agent GC-1 induces hepatocyte proliferation via Wnt/β-catenin signaling and may promote regeneration in both acute and chronic liver ...
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PSMA Ligands for PET Imaging of Prostate Cancer - Journal of Nuclear Medicine
Posted: July 7th, 2017, 5:00am GMT
PSMA Ligands for PET Imaging of Prostate Cancer Journal of Nuclear Medicine+ Author Affiliations. 1Department of Nuclear Medicine, Rostock University Medical Centre, Rostock, Germany. 2Department of Nuclear Medicine, Klinikum ...
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Drug and Device News July 2017 - P&T Community
Posted: June 23rd, 2017, 7:54pm GMT
Drug and Device News July 2017 P&T CommunityApprovals, new indications, regulatory activities, and more.
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The secret to combating pancreatic cancer may lie in suppression of a common protein - Science Daily
Posted: May 22nd, 2017, 5:00am GMT
The secret to combating pancreatic cancer may lie in suppression of a common protein Science DailyIn mice with a KRAS mutation, which is present in 90 percent of pancreatic cancer patients, expressing only half the amount of the glucose-regulated protein ...
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Can Artificial Sweeteners Reduce Pancreatic Cancer Risk? - News-Medical.net
Posted: May 4th, 2017, 5:00am GMT
Can Artificial Sweeteners Reduce Pancreatic Cancer Risk? News-Medical.netPancreatic cancer claims the fourth highest spot on the list of cancer-related mortality, despite the fact that it doesn't even make the top ten for incidence.
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Casper WY Firefighter's Family To Receive Benefits Thanks To New Law - Firefighter News - Firehouse.com
Posted: April 25th, 2017, 1:46pm GMT
Casper WY Firefighter's Family To Receive Benefits Thanks To New Law - Firefighter News Firehouse.comCasper firefighter's family to automatically receive benefits after he loses battle with cancer.
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Casper fire captain dies of cancer, the first firefighter to qualify under new workers compensation law - Casper Star-Tribune Online
Posted: April 24th, 2017, 5:00am GMT
Casper fire captain dies of cancer, the first firefighter to qualify under new workers compensation law Casper Star-Tribune OnlineA Casper firefighter died Saturday night after an extended battle with pancreatic cancer.
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Primary pancreatic lymphoma: two case reports and a literature review | OTT - Dove Medical Press
Posted: March 20th, 2017, 5:00am GMT
Primary pancreatic lymphoma: two case reports and a literature review | OTT Dove Medical PressPrimary pancreatic lymphoma: two case reports and a literature review Lili Yu,1,2,* Yajun Chen,1,2,* Ligang Xing2 1School of Medicine and Life Sciences, ...
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Therapeutic Implications of Molecular Subtyping for Pancreatic Cancer - Cancer Network
Posted: March 15th, 2017, 5:00am GMT
Therapeutic Implications of Molecular Subtyping for Pancreatic Cancer Cancer NetworkIn this article, we review seminal articles that have evaluated the molecular architecture of pancreatic cancer. We compare the methods used and the molecular ...
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Adenosquamous Carcinoma of the Prostate: A Rare Aggressive Tumor with a Review of the Literature - UroToday
Posted: January 31st, 2017, 11:31am GMT
Adenosquamous Carcinoma of the Prostate: A Rare Aggressive Tumor with a Review of the Literature UroTodayABSTRACT. Adenosquamous carcinoma (ASCC) of the prostate is an extremely rare, aggressive neoplasm with only few cases are reported in literature.
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UCSD helps lead ambitious study of 80 rare cancers - The San Diego Union-Tribune
Posted: January 18th, 2017, 6:00am GMT
UCSD helps lead ambitious study of 80 rare cancers The San Diego Union-TribuneUC San Diego researchers are playing big roles in an innovative, nationwide clinical trial to see whether 80 rare cancers can be treated with drugs from the ...
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Lung adenocarcinoma mimicking pulmonary fibrosis-a case report - BMC Blogs Network
Posted: September 13th, 2016, 5:00am GMT
Lung adenocarcinoma mimicking pulmonary fibrosis-a case report BMC Blogs NetworkLung cancer is usually presented with cough, dyspnea, pain and weight loss, which is overlapping with symptoms of other lung diseases such as pulmonary ...
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Upregulation of Key Molecules for Targeted Imaging and Therapy - Journal of Nuclear Medicine
Posted: June 30th, 2016, 5:00am GMT
Upregulation of Key Molecules for Targeted Imaging and Therapy Journal of Nuclear Medicine+ Author Affiliations. 1Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland. 2Clinical Radiopharmacy, Department of Clinical ...
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Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study - Journal of Nuclear Medicine
Posted: June 23rd, 2016, 5:00am GMT
Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study Journal of Nuclear Medicine+ Author Affiliations. 1Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 2Nuclear ...
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68Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer - Journal of Nuclear Medicine
Posted: June 3rd, 2016, 5:00am GMT
68Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer Journal of Nuclear Medicine+ Author Affiliations. 1Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany. 2Institute for Clinical Radiology, ...
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Combination Immunotherapy Shows New Promise for Lung Cancer - Memorial Sloan Kettering Cancer Center
Posted: June 1st, 2016, 5:00am GMT
Combination Immunotherapy Shows New Promise for Lung Cancer Memorial Sloan Kettering Cancer CenterImmunotherapy has emerged as a promising new treatment option for people with lung cancer. MSK scientists are conducting research to enable more patients ...
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Researchers identify drug therapy for pancreatic cancer - UPI.com
Posted: May 26th, 2016, 5:00am GMT
Researchers identify drug therapy for pancreatic cancer UPI.comA rare form of pancreatic cancer is susceptible to a chemotherapy drug typically used for colorectal cancers, according to new research from the Mayo Clinic.
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Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA) - Nature.com
Posted: April 20th, 2016, 5:00am GMT
Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA) Nature.comCholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver ...
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Types of Hematuria - News-Medical.net
Posted: April 14th, 2016, 12:15am GMT
Types of Hematuria News-Medical.netHematuria is a health condition that is characterized by the presence of blood in the urine. There are two main types of hematuria: microscopic and macroscopic.
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Image-based computational quantification and visualization of genetic alterations and tumour heterogeneity - Nature.com
Posted: April 7th, 2016, 5:00am GMT
Image-based computational quantification and visualization of genetic alterations and tumour heterogeneity Nature.comRecent large-scale genome analyses of human tissue samples have uncovered a high degree of genetic alterations and tumour heterogeneity in most tumour ...
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Micropapillary: A component more likely to harbour heterogeneous EGFR mutations in lung adenocarcinomas - Nature.com
Posted: April 5th, 2016, 5:00am GMT
Micropapillary: A component more likely to harbour heterogeneous EGFR mutations in lung adenocarcinomas Nature.comThe micropapillary (MP) subtype has recently been established to be a distinct marker of poor prognosis in lung adenocarcinomas (LACs). According to the ...
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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #17: Development and Maintenance of the Islet Beta Cell Part 1 of 4 - Diabetes In Control
Posted: March 29th, 2016, 5:00am GMT
International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #17: Development and Maintenance of the Islet Beta Cell Part 1 of 4 Diabetes In ControlIntroduction. The discovery of insulin by Banting and Best in the early 1920s marked the beginning of a new era of diabetes research that focused on the study of ...
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Ground-Glass Opacity Lung Nodules in the Era of Lung Cancer CT Screening: Radiology, Pathology, and Clinical Management - Cancer Network
Posted: March 16th, 2016, 5:00am GMT
Ground-Glass Opacity Lung Nodules in the Era of Lung Cancer CT Screening: Radiology, Pathology, and Clinical Management Cancer NetworkThe advent of computed tomography screening for lung cancer will increase the incidence of ground-glass opacity (GGO) nodules detected and referred for ...
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Endoscopic ultrasound-guided fine needle core biopsy for the diagnosis of pancreatic malignant lesions: a systematic review and Meta-Analysis - Nature.com
Posted: March 10th, 2016, 6:00am GMT
Endoscopic ultrasound-guided fine needle core biopsy for the diagnosis of pancreatic malignant lesions: a systematic review and Meta-Analysis Nature.comEndoscopic ultrasound-guided fine needle core biopsy (EUS-FNB) has been used as an effective method of diagnosing pancreatic malignant lesions. It has the ...
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Genomic Analysis Yields Four Subtypes of Pancreatic Cancer - Cancer Network
Posted: March 9th, 2016, 6:00am GMT
Genomic Analysis Yields Four Subtypes of Pancreatic Cancer Cancer NetworkAn integrated genomic analysis has found that pancreatic cancer can be divided into four specific subtypes based on molecular characteristics. This division ...
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Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma - Nature.com
Posted: March 4th, 2016, 6:00am GMT
Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma Nature.comUveal melanoma (UM) is the most common intraocular malignancy in adults. Despite improvements in surgical, radiation and chemotherapy treatments, the ...
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Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation - Nature.com
Posted: March 2nd, 2016, 6:00am GMT
Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation Nature.comTrafficking of the G protein-coupled receptor (GPCR) Smoothened (Smo) to the primary cilium (PC) is a potential target to inhibit oncogenic Hh pathway ...
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Screening for major driver oncogene alterations in adenosquamous lung carcinoma using PCR coupled with next-generation and Sanger sequencing methods - Nature.com
Posted: February 29th, 2016, 6:00am GMT
Screening for major driver oncogene alterations in adenosquamous lung carcinoma using PCR coupled with next-generation and Sanger sequencing methods Nature.comWe investigated the frequency of major driver oncogenes in lung adenosquamous cell carcinoma (ASC) cases. Frequency of EGFR, K-Ras, B-Raf, PIK3CA, ...
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Variation in KRAS driver substitution distributions between tumor types is determined by both mutation and natural selection - Nature.com
Posted: February 23rd, 2016, 6:00am GMT
Variation in KRAS driver substitution distributions between tumor types is determined by both mutation and natural selection Nature.comDifferent tumor types vary greatly in their distribution of driver substitutions. Here, we analyzed how mutation and natural selection contribute to differences in the ...
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Photoacoustic monitoring of tumor and normal tissue response to radiation - Nature.com
Posted: February 17th, 2016, 6:00am GMT
Photoacoustic monitoring of tumor and normal tissue response to radiation Nature.comHypoxia is a recognized characteristic of tumors that influences efficacy of radiotherapy (RT). Photoacoustic imaging (PAI) is a relatively new imaging technique ...
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PNA lectin for purifying mouse acinar cells from the inflamed pancreas - Nature.com
Posted: February 17th, 2016, 6:00am GMT
PNA lectin for purifying mouse acinar cells from the inflamed pancreas Nature.comBetter methods for purifying human or mouse acinar cells without the need for genetic modification are needed. Such techniques would be advantageous for the ...
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Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma - Nature.com
Posted: February 16th, 2016, 6:00am GMT
Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma Nature.comThree-dimensional cell culture methods are viable in vitro approaches that facilitate the examination of biological features cancer cells present in vivo.
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Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green - Nature.com
Posted: February 11th, 2016, 6:00am GMT
Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green Nature.comTissue necrosis commonly accompanies the development of a wide range of serious diseases. Therefore, highly sensitive detection and precise boundary ...
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Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties - Nature.com
Posted: January 25th, 2016, 6:00am GMT
Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties Nature.comAdvanced prostate adenocarcinomas enriched in stem-cell features, as well as variant androgen receptor (AR)-negative neuroendocrine (NE)/small-cell ...
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Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas - Nature.com
Posted: January 14th, 2016, 6:00am GMT
Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas Nature.comTranscriptional and signaling networks establish complex cross-regulatory interactions that drive cellular differentiation during development. Using microarrays ...
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The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL - Nature.com
Posted: January 5th, 2016, 6:00am GMT
The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL Nature.comTumor cell metastasis is a complex process that has been mechanistically linked to the epithelial-mesenchymal transition (EMT). The double-negative feedback ...
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Chronic Pancreatitis to Pancreatic Cancer - Medscape
Posted: December 17th, 2015, 6:00am GMT
Chronic Pancreatitis to Pancreatic Cancer MedscapeDr Lowenfels reviews a mini-symposium on chronic pancreatitis, pancreatic cancer, and type 3c diabetes that was held at the 46th Annual Meeting of the ...
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NES1/KLK10 gene represses proliferation, enhances apoptosis and down-regulates glucose metabolism of PC3 prostate cancer cells - Nature.com
Posted: November 30th, 2015, 6:00am GMT
NES1/KLK10 gene represses proliferation, enhances apoptosis and down-regulates glucose metabolism of PC3 prostate cancer cells Nature.comThe normal epithelial cell-specific-1 (NES1) gene, also named as KLK10, is recognised as a novel putative tumour suppressor in breast cancer, but few studies ...
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Downregulation of the small GTPase SAR1A: a key event underlying alcohol-induced Golgi fragmentation in hepatocytes - Nature.com
Posted: November 26th, 2015, 6:00am GMT
Downregulation of the small GTPase SAR1A: a key event underlying alcohol-induced Golgi fragmentation in hepatocytes Nature.comThe hepatic asialoglycoprotein receptor (ASGP-R) is posttranslationally modified in the Golgi en route to the plasma membrane, where it mediates clearance of ...
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Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade - Science Magazine
Posted: November 25th, 2015, 6:00am GMT
Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade Science MagazineOverexpression of the human epidermal growth factor receptor 2 (HER2) is common in breast cancer, and it is associated with poor outcomes despite the ...
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Immediate Repeat Prostate Biopsy May Be Unnecessary in Most ASAP Cases - Renal and Urology News
Posted: November 19th, 2015, 6:00am GMT
Immediate Repeat Prostate Biopsy May Be Unnecessary in Most ASAP Cases Renal and Urology NewsImmediate repeat prostate biopsy may be unnecessary for most men with atypical small acinar proliferation (ASAP), researchers concluded. ASAP occurs in ...
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Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis - Nature.com
Posted: November 16th, 2015, 6:00am GMT
Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis Nature.comPancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic and inflammatory microenvironment that is formed primarily by activated, ...
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Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer - Nature.com
Posted: November 4th, 2015, 6:00am GMT
Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer Nature.comGlucose-regulated protein 78 (GRP78) is a member of the heat-shock protein 70 family. We evaluated the expression of GRP78 using tissue microarray-based ...
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Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization - Nature.com
Posted: October 16th, 2015, 5:00am GMT
Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization Nature.com3D tissue culture models are utilized to study breast cancer and other pathologies because they better capture the complexity of in vivo tissue architecture ...
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The basic helix-loop-helix transcription factor, Mist1, induces maturation of mouse fetal hepatoblasts - Nature.com
Posted: October 12th, 2015, 5:00am GMT
The basic helix-loop-helix transcription factor, Mist1, induces maturation of mouse fetal hepatoblasts Nature.comHepatic stem/progenitor cells, hepatoblasts, have a high proliferative ability and can differentiate into mature hepatocytes and cholangiocytes. Therefore, these ...
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Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis - Journal of Virology
Posted: September 22nd, 2015, 2:41pm GMT
Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis Journal of VirologyViral myocarditis, which is most prevalently caused by coxsackievirus B3 (CVB3), is a serious clinical condition characterized by excessive myocardial ...
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Aggressive Lung Adenocarcinoma Subtype May Require New Treatment Strategy - Memorial Sloan Kettering Cancer Center
Posted: September 17th, 2015, 5:00am GMT
Aggressive Lung Adenocarcinoma Subtype May Require New Treatment Strategy Memorial Sloan Kettering Cancer CenterDoctors are now able to identify whether patients with early-stage lung adenocarcinoma have an aggressive form called solid predominant subtype. Following ...
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Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer - Science Magazine
Posted: September 16th, 2015, 5:00am GMT
Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer Science MagazineRadiotherapy for head and neck cancer may damage the salivary glands, resulting in reduced salivation with consequent xerostomia (dry mouth). Xerostomia ...
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Differences in Clinicopathology of Early Gastric Carcinoma between Proximal and Distal Location in 438 Chinese Patients - Nature.com
Posted: August 27th, 2015, 5:00am GMT
Differences in Clinicopathology of Early Gastric Carcinoma between Proximal and Distal Location in 438 Chinese Patients Nature.comEarly gastric carcinoma (EGC) in Chinese patients remains poorly understood and endoscopic therapy has not been well established. Here, we compared ...
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Overexpression Of Hepatocyte Nuclear Factor-1beta Predicting Poor Prognosis Is Associated With Biliary Phenotype In Patients With Hepatocellular Carcinoma - Nature.com
Posted: August 27th, 2015, 5:00am GMT
Overexpression Of Hepatocyte Nuclear Factor-1beta Predicting Poor Prognosis Is Associated With Biliary Phenotype In Patients With Hepatocellular Carcinoma Nature.comHepatocyte nuclear factor-1beta (HNF-1B) is involved in the hepatobiliary specification of hepatoblasts to cholangiocytes during liver development, and is ...
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Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype - Nature.com
Posted: August 20th, 2015, 5:00am GMT
Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype Nature.comSalivary duct carcinoma (SDC) is an uncommon, but aggressive malignant tumor with a high mortality rate. Herein, we reported the detection of somatic KRAS ...
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Histologic Classification Could Aid Prognosis in Lung Adenocarcinoma - Cancer Network
Posted: August 11th, 2015, 5:00am GMT
Histologic Classification Could Aid Prognosis in Lung Adenocarcinoma Cancer NetworkNew classification guidelines for histologic subtypes of stage I lung adenocarcinoma offer prognostic value, according to a recent study.
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The virus-induced protein APOBEC3G inhibits anoikis by activation of Akt kinase in pancreatic cancer cells - Nature.com
Posted: July 16th, 2015, 5:00am GMT
The virus-induced protein APOBEC3G inhibits anoikis by activation of Akt kinase in pancreatic cancer cells Nature.comPancreatic cancer is one of the more common cancers with a poor prognosis. Some varieties of cancer are related to virus infection. As a virus-induced protein, ...
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Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract - Science Magazine
Posted: July 14th, 2015, 5:00am GMT
Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract Science MagazineAbstract. It has long been known that differentiated cells can switch fates, especially in vitro, but only recently has there been a critical mass of publications ...
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IL-17A and its homologs IL-25/IL-17E recruit the c-RAF/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells - Nature.com
Posted: July 8th, 2015, 5:00am GMT
IL-17A and its homologs IL-25/IL-17E recruit the c-RAF/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells Nature.comPro-inflammatory IL-17 cytokines were initially described for their pathogenic role in chronic inflammatory diseases and subsequent accumulating evidence ...
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Heat-shock factor 2 is a suppressor of prostate cancer invasion - Nature.com
Posted: June 29th, 2015, 5:00am GMT
Heat-shock factor 2 is a suppressor of prostate cancer invasion Nature.comHeat-shock factors (HSFs) are key transcriptional regulators in cell survival. Although HSF1 has been identified as a driver of carcinogenesis, HSF2 has not ...
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Pathophysiological role of microRNA-29 in pancreatic cancer stroma - Nature.com
Posted: June 22nd, 2015, 5:00am GMT
Pathophysiological role of microRNA-29 in pancreatic cancer stroma Nature.comDense fibrotic stroma associated with pancreatic ductal adenocarcinoma (PDAC) is a major obstacle for drug delivery to the tumor bed and plays a crucial role in ...
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Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers - Nature.com
Posted: June 15th, 2015, 5:00am GMT
Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers Nature.comDifferentiated epithelial structure communicates with individual constituent epithelial cells to suppress their proliferation activity. However, the pathways linking ...
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A microRNA code for prostate cancer metastasis - Nature.com
Posted: June 15th, 2015, 5:00am GMT
A microRNA code for prostate cancer metastasis Nature.comAlthough the development of bone metastasis is a major detrimental event in prostate cancer, the molecular mechanisms responsible for bone homing and ...
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Caveolin-1 is Associated with Tumor Progression and Confers a Multi-Modality Resistance Phenotype in Pancreatic Cancer - Nature.com
Posted: June 12th, 2015, 5:00am GMT
Caveolin-1 is Associated with Tumor Progression and Confers a Multi-Modality Resistance Phenotype in Pancreatic Cancer Nature.comCaveolin-1 (Cav-1) is a 21 kDa protein enriched in caveolae, and has been implicated in oncogenic cell transformation, tumorigenesis, and metastasis.
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Component in green tea may help reduce prostate cancer in men at high risk - Science Daily
Posted: May 28th, 2015, 5:00am GMT
Component in green tea may help reduce prostate cancer in men at high risk Science DailyProstate cancer is the second most common type of cancer in men and is predicted to result in an estimated 220000 cases in the United States in 2015. A team ...
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Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma - Nature.com
Posted: May 27th, 2015, 5:00am GMT
Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma Nature.comLiver kinase B1 (LKB1) has been identified as a critical modulator involved in cell proliferation and polarity. The purpose of the current study was to characterize ...
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Adult metanephric adenoma presumed to be all benign? A clinical perspective - BMC Blogs Network
Posted: April 25th, 2015, 5:00am GMT
Adult metanephric adenoma presumed to be all benign? A clinical perspective BMC Blogs NetworkIn most documented literature, metanephric adenoma (MA) is described as a benign tumour. Nevertheless, the nature of MA remains unclear and the clinical ...
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Returning Pancreatic Cancer Cells to Normal - Genetic Engineering & Biotechnology News
Posted: April 21st, 2015, 5:00am GMT
Returning Pancreatic Cancer Cells to Normal Genetic Engineering & Biotechnology NewsA silent disease is often characterized as showing little to no signs or symptoms until the disease has progressed to an advanced stage—pancreatic ...
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Vitals - News of Record | KP - Kokomo Perspective
Posted: February 10th, 2015, 6:00am GMT
Vitals - News of Record | KP Kokomo PerspectiveCRIMINAL SENTENCINGS. The following are the sentencings of criminal cases heard in all five Howard County courts. Circuit Court. advertisement.
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Ski regulates Hippo and TAZ signaling to suppress breast cancer progression - Science Magazine
Posted: February 10th, 2015, 6:00am GMT
Ski regulates Hippo and TAZ signaling to suppress breast cancer progression Science MagazineActivation of the kinases in the Hippo pathway triggers the phosphorylation, cystolic sequestration, and degradation of the transcriptional coactivator TAZ, ...
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Variation in cancer risk among tissues can be explained by the number of stem cell divisions - Science Careers Blog
Posted: January 1st, 2015, 5:04pm GMT
Variation in cancer risk among tissues can be explained by the number of stem cell divisions Science Careers BlogWhy do some tissues give rise to cancer in humans a million times more frequently than others? Tomasetti and Vogelstein conclude that these differences can ...
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Adenosquamous Carcinoma of the Prostate: A Rare Aggressive Tumor with a Review of the Literature - UroToday
Posted: October 20th, 2014, 2:48pm GMT
Adenosquamous Carcinoma of the Prostate: A Rare Aggressive Tumor with a Review of the Literature UroTodayABSTRACT. Adenosquamous carcinoma (ASCC) of the prostate is an extremely rare, aggressive neoplasm with only few cases are reported in literature.
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Nigeria: Cassava Leaves, Roots Show Promise Against Colon Cancer, Heart Attack, Others - The Guardian
Posted: September 18th, 2014, 5:00am GMT
Nigeria: Cassava Leaves, Roots Show Promise Against Colon Cancer, Heart Attack, Others The GuardianAnalysis - Can cassava leaves and roots extract provide the elusive cure for colon, prostate and bladder cancers? Can tiny tubes made from cassava root extract ...