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Posted: August 30th, 2018, 5:00am GMT

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lobular breast carcinoma in situ child sexual abuse poems - French Tribune

Posted: August 12th, 2018, 8:16pm GMT

lobular breast carcinoma in situ child sexual abuse poems
French Tribune
lobular breast carcinoma in situ. Lobular carcinoma healing from sexual abuse poems in situ lcis is an incidental microscopic finding with characteristic cellular morphology and multifocal tissue patterns.The condition is a laboratory diagnosis and ...

Acinic Cell Carcinoma - News-Medical.net

Posted: June 20th, 2018, 11:28pm GMT

News-Medical.net

Acinic Cell Carcinoma
News-Medical.net
Acinic cell carcinoma is a rare cancer of the salivary glands that originates from the parotid gland. It is a low-grade salivary neoplasm that constitutes about 5% to 17% of cases involving salivary gland malignancies. In comparison with other salivary ...

Malignant Epithelioid Mesothelioma - Asbestos.com

Posted: May 12th, 2018, 1:52pm GMT

Malignant Epithelioid Mesothelioma
Asbestos.com
Epithelioid patients diagnosed before the cancer has spread throughout the chest often qualify for multimodal therapy, which attempts to kill cancer cells using multiple types or modes of therapy. Multimodal therapy combines the most effective ...

Hydrogel microenvironments for cancer spheroid growth and drug screening - Science Advances

Posted: April 27th, 2018, 4:09pm GMT

Hydrogel microenvironments for cancer spheroid growth and drug screening
Science Advances
Biomimetic hydrogel scaffolds for MCS growth offer a broad spectrum of biophysical and biochemical cues that help to recapitulate the behavior of natural extracellular matrix, essential for regulating cancer cell behavior. This perspective highlights ...

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Permalink for 'Clinicopathological analysis of programmed death-ligand 1 testing in tumor cells of 325 patients with non-small cell lung cancer: Its predictive and potential prognostic value.'

Clinicopathological analysis of programmed death-ligand 1 testing in tumor cells of 325 patients with non-small cell lung cancer: Its predictive and potential prognostic value.

Fetched: November 19th, 2018, 5:00am GMT

Clinicopathological analysis of programmed death-ligand 1 testing in tumor cells of 325 patients with non-small cell lung cancer: Its predictive and potential prognostic value.

Cesk Patol. 2018;54(3):137-142

Authors: Farkašová A, Tancoš V, Kviatkovská Z, Huťka Z, Mičák J, Scheerová K, Szépe P, Plank L

Abstract
INTRODUCTION: Recent studies on check-point inhibitor therapy, which seems to improve the prognosis of patients with advanced non-small cell lung carcinoma increase the importance of immunohistochemical analyses of the programmed-death receptor and of its ligand, PD-L1 protein.
MATERIAL AND METHODS: In our study we present results of PD-L1 immunohistochemical tumor cell expression in a series of 325 lung carcinoma patients biopsies, using the clone 22C3 (and DAKO Link 48 immunostainer). Evaluation of the expression using tissue proportion scoring system allowed to distinguish negative cases (either 0 % or < 1 % of positive tumor cells) versus positive cases in the categories 1-9 %, 10-49 % and ≥ 50 % of positive tumor cells.
RESULTS: In association to histopathologic parameters we observed similar rates of positive expression in patients with adenocarcinoma types (47,8 % of all the cases) as well as with squamous cell carcinomas (44,4 %). Within these histological categories, the rates of positivity were similar also in patients with small versus large (resectional) biopsies. In the biopsies of patients with adenocarcinoma we identified differences in the PD-L1 protein expression associated with its histological subtype. In the cases with predominant lepidic pattern the PD-L1 positivity was present in 18,8 %, with predominant acinar or papillary pattern in 40,8 % and in cases with predominant solid or micropapillary component in 74,1 % of the cases resp. Keratinizing squamous cell carcinomas were positive in 38,5 % and non-keratinizing in 53,8 % of all the cases. The hiqhest incidence of an extensive posivity was observed in sarcomatoid carcinoma type.
DISCUSSION AND CONCLUSION: Immunohistochemically verified PD-L1 protein expression represents a broadly accepted predictive biomarker for immunotherapy of NSCLC patients. The indicated differences of the expression among various NSCLC types and subtypes require to be verified in larger cohorts of patients in relation with clinical parameters to demonstrate whether it could be plausible to use the PD-L1 expression in a role of a negative prognostic parameter.

PMID: 30445818 [PubMed - in process]

Acinic cell carcinoma of the parotid gland in pregnancy: an approach to cancer in pregnancy.

Fetched: November 15th, 2018, 5:00am GMT

Acinic cell carcinoma of the parotid gland in pregnancy: an approach to cancer in pregnancy.

BMJ Case Rep. 2018 Jul 24;2018:

Authors: Cellich PP, Nayyar R, Wong E

Abstract
A 27-year-old woman presented with an enlarging painless right preauricular mass at 28 weeks' pregnant. The mass had been stable for more than 10 years, but showed rapid growth during pregnancy. Imaging and biopsy were consistent with parotid gland malignancy, with surgical resection undertaken at 33+4 weeks' gestation. Histopathology confirmed acinic cell carcinoma. Labour was induced without complication at 36+6 weeks' gestation and adjuvant radiotherapy commenced 2 weeks postpartum. At 9 months follow-up, both mother and baby were well, with no signs of disease recurrence. Rapid progression in pregnancy, of a previously stable salivary gland mass, is a common feature among reported cases and was also observed in the current case. This suggests an aetiological link between pregnancy and salivary gland tumour progression. We demonstrate successful management of a parotid gland malignancy in pregnancy and review guiding principles for cancer management in pregnancy.

PMID: 30042101 [PubMed - indexed for MEDLINE]

Pancreatic acinar cell carcinoma-case report and literature review.

Fetched: November 11th, 2018, 5:00am GMT

Pancreatic acinar cell carcinoma-case report and literature review.

BMC Cancer. 2018 Nov 08;18(1):1083

Authors: Xing-Mao Z, Hong-Juan Z, Qing L, Qiang H

Abstract
BACKGROUND: Pancreatic acinar cell carcinoma (ACC) is a rare tumor that constitutes 1% of all pancreatic neoplasms. Pancreatic ACC has unique characteristics in terms of biological behavior, imaging and prognosis.
CASE PRESENTATION: The present study reported two cases of pancreatic ACC confirmed by postoperative pathology and both cases exhibited several different imaging features and laboratory test results. Both cases had approximately 4 cm mass located in uncinate process of pancreas. Dilated intra- and extra-hepatic bile ducts was observed in one case, along with calcification. Heterogeneous enhancement of the tumor was exhibited in both patients with different intensities. Obstructive jaundice, elevated α-fetoprotein and CA 19-9 was found in one case, while the other case had normal liver function and tumor markers.
CONCLUSIONS: It was difficult to accurately diagnose pancreatic ACC before the operation despite its unique characteristics. Radical resection was the best treatment modality for resectable pancreatic ACC.

PMID: 30409114 [PubMed - in process]

Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib: A case report.

Fetched: November 10th, 2018, 5:00am GMT

Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib: A case report.

Medicine (Baltimore). 2018 Nov;97(45):e13113

Authors: Li M, Mou Y, Hou S, Cao D, Li A

Abstract
RATIONALE: Pancreatic acinar cell carcinoma (PACC) is a relatively rare malignancy of the exocrine pancreas. BRCA2, a cancer susceptibility gene, has been widely studied in breast and ovarian carcinomas as mutation carriers for this gene are at a high risk for cancer development. Olaparib, an oral poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor, has been approved for the treatment of ovarian cancer with any BRCA 1/2 mutations. Herein, we report the first case of a germline BRCA2-mutated unresectable advanced PACC patient who responded well to olaparib treatment.
PATIENT CONCERNS: A 59-year-old male with a family history of cancer presented with a persistent epigastric dull pain for 3 months.
DIAGNOSIS: The patient was diagnosed with advanced PACC based on computed tomography (CT) scan, laparotomy, and pathology.
INTERVENTIONS: Exploratory laparotomy, intratumoral brachytherapy by radioiodine-125 seeds, modified FOLFIRINOX chemotherapy, and targeted therapy with olaparib were administered.
OUTCOMES: The patient responded well to olaparib until the occurrence of severe adverse drug reactions, he died as a result of multiple organ failure with an overall survival period of 12 months.
LESSONS: As a PARP inhibitor, olaparib has remarkable curative effect not only on breast and ovarian cancers, but also on other malignancies with BRCA mutations. Patients with advanced cancer could benefit from active targeted therapy with improvement in overall survival and quality of life.

PMID: 30407325 [PubMed - in process]

[Visually Isoattenuating Pancreatic Acinar Cell Carcinoma:Report of One Case].

Fetched: November 10th, 2018, 5:00am GMT

[Visually Isoattenuating Pancreatic Acinar Cell Carcinoma:Report of One Case].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2018 Oct 30;40(5):714-718

Authors: Li J, Chang XY, Zhu L, Dai MH, Xue HD

Abstract
Acinar cell carcinoma of pancreas(ACCP)is a rare pancreatic exocrine tumor that accounts for about 1% of pancreatic tumors. The typical imaging manifestations of ACCP are as follows:(1)the tumor is large in volume,partially or completely exophytic;(2)complete or incomplete capsule is visible with thin linear enhancement;(3)CT density and MRI signal:plain CT images reveals that the tumors have similar or slightly hypodense densities relative to the adjacent normal pancreas,the solid part of ACCP has low to intermediate signal intensity on T1WI and intermediate to high signal intensity on T2WI compared with the surrounding normal pancreas;(4)pattern of enhancement:tumors exhibit heterogeneous enhancement and it is less than that in the surrounding normal pancreas;(5)fissure-like,swirling necrosis that may be a characteristic change of tumor;(6)pancreatic and biliary duct dilatation is rare;(7)adjacent organs and blood vessels around the pancreas may be invaded;(8)distant metastasis of liver and other parts may be observed;(9)PET-CT shows high FDG uptake. An ACCP patient with atypical imaging manifestations was treated in Peking Union Medical College Hospital from November 2015 to August 2017. The lesion manifested iso-enhancement and many imaging examinations failed to find the tumor. The patient ultimately underwent surgery and diagnosed as ACCP by pathology.

PMID: 30404708 [PubMed - in process]

Unusual gastric subepithelial tumor: primary mixed acinar-endocrine neoplasm in an anemic woman.

Fetched: November 8th, 2018, 5:00am GMT

Unusual gastric subepithelial tumor: primary mixed acinar-endocrine neoplasm in an anemic woman.

Gastrointest Endosc. 2018 May;87(5):1355-1356

Authors: Uraizee I, Hart J, Waxman I, Weber CR, Setia N

PMID: 29102730 [PubMed - indexed for MEDLINE]

Immune infiltrates and PD-L1 expression in treatment-naïve acinar prostatic adenocarcinoma: an exploratory analysis.

Fetched: October 31st, 2018, 5:00am GMT

Immune infiltrates and PD-L1 expression in treatment-naïve acinar prostatic adenocarcinoma: an exploratory analysis.

J Clin Pathol. 2018 Nov;71(11):1023-1027

Authors: Hahn E, Liu SK, Vesprini D, Xu B, Downes MR

Abstract
Tumour-induced immunosuppression plays a role in the development and progression of cancer. Of interest is the interaction between programmed death-1 and programmed death ligand-1 (PD-L1) which can be targeted through immune checkpoint blockade; however, there are limited data surrounding the composition of the immune milieu in prostate cancer. We preliminarily assessed 21 radical prostatectomies in therapy-naïve patients for immune markers and PD-L1 expression. The immune infiltrates were higher in adenocarcinoma than benign prostate (lymphocytes p<0.001, macrophages p=0.010) with 5% of cases being PD-L1 high (≥5% expression). Increased peritumoural CD68 and CD163 expression correlated with lower grade group (GG) (p=0.024 and p=0.014, respectively) with a trend towards increased CD68 expression in lower stage cases (p=0.086). There was also increased CD45 expression in lower GGs (p=0.063). We found the immune infiltrate in acinar prostate cancer to be extremely heterogeneous with an overall immunophenotype unlikely to respond to immune checkpoint blockade.

PMID: 30257853 [PubMed - indexed for MEDLINE]

A novel experimental model for human mixed acinar-ductal pancreatic cancer.

Fetched: October 27th, 2018, 5:00am GMT

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A novel experimental model for human mixed acinar-ductal pancreatic cancer.

Carcinogenesis. 2018 02 09;39(2):180-190

Authors: Doiron B, DeFronzo RA

Abstract
Pancreatic cancer has remained refractory to treatment. In large part, this results from the lack of an animal model that mimics pancreatic cancer in man. We describe a novel experimental model of pancreatic cancer that shares the genetic background, histologic features and natural history of human mixed acinar-ductal carcinoma. Adult wild-type mice received an injection into the pancreatic duct of lentivirus coding two molecules, KrasG12D mutation and shRNA p53, which recapitulate the mechanisms of pancreatic cancer in humans. The lentivirus constructs also co-expressed the luciferase gene for in vivo imaging by bioluminescence using the Xenogen IVIS imaging system. Weeks post-injection wild-type mice develop pancreatic cancer with the same histologic characteristics and metastases observed with human pancreatic mixed acinar-ductal carcinoma. This novel approach represents the first pancreatic cancer model that does not involve alterations of embryonic development, which is inherent with transgenic mice or knockout mice models. This novel experimental human pancreatic cancer model can be used to more effectively test new anti-cancer drug to inhibit tumor progression in situ and to retard metastases. Furthermore, our method of injecting lentivirus containing oncogenes and molecules implicated in the development of pancreatic can be employed in diabetic and obese mice, two common metabolic conditions characterized by an increased incidence of pancreatic cancer.

PMID: 29106450 [PubMed - indexed for MEDLINE]

Potential therapeutic effects of induced pluripotent stem cells on induced salivary gland cancer in experimental rats.

Fetched: October 21st, 2018, 5:00am GMT

Potential therapeutic effects of induced pluripotent stem cells on induced salivary gland cancer in experimental rats.

Biotech Histochem. 2018 Oct 19;:1-8

Authors: Alaa El-Din Y, Sabry D, Abdelrahman AH, Fathy S

Abstract
Salivary gland neoplasms exhibit complex histopathology in a variety of tumor types and treatment options depend largely on the stage of the cancer. Induced pluripotent stem cells (iPS) have been investigated for treating induced salivary gland cancer and for restoring salivary gland function. We investigated iPS treatment for salivary gland cancer both in vitro and in vivo. For our study in vitro, we re-programmed human skin fibroblasts to form iPS cells using a plasmid containing Oct4, Sox2, L-MYC and LIN28. For our study in vivo, we used 30 white male albino rats divided into the following groups of 10: group 1 (control): rats were injected with phosphate-buffered saline (PBS), group 2 induced squamous cell carcinoma (SCC): rat submandibular glands were injected with squamous carcinoma cells (SCC), group 3 (induced SCC/iPS): SCC treated rats treated with 5 × 106 iPS cells. Submandibular glands from rats of all groups were examined histologically and real time PCR was performed for amylase, and COX I and COX II gene expression. We confirmed that submandibular gland specimens included tumor tissue before starting treatment with iPS. iPS treated cases exhibited regeneration of salivary glands, although minor degenerative and vascularization changes remained. The acinar cells regained their proper organization, but continued to exhibit abnormal activity including hyperchromatism. iPS cells may be useful for treating salivary gland carcinomas.

PMID: 30338701 [PubMed - as supplied by publisher]

Lung adenocarcinoma with concurrent ALK and ROS1 rearrangement: A case report and review of the literatures.

Fetched: October 19th, 2018, 5:00am GMT

Lung adenocarcinoma with concurrent ALK and ROS1 rearrangement: A case report and review of the literatures.

Pathol Res Pract. 2018 Oct 01;:

Authors: Deng H, Liu C, Zhang G, Wang X, Liu Y

Abstract
ALK and ROS1 are prognostic and predictive tumor markers in non-small cell lung carcinoma (NSCLC), which are more often found in lung adenocarcinomas as with other oncogenes such as EGFR, KRAS, or C-MET. Their positivity is 2.6% and 1.3%, respectively, and patients who have mutations in both genes are extremely rare. Here, we report a 61-year-old male diagnosed with acinar adenocarcinoma, who was shown to have both ALK and ROS1 rearrangements but was EGFR- and C-MET mutation-negative. He was treated surgically and received targeted therapy. Our review of the literature revealed that few such cases of concurrent ALK and ROS1 rearrangements have been reported. This information furthers our understanding of the molecular biology underlying NSCLC which will aid the selection of optimal treatment for patients with more than one driver mutation.

PMID: 30327151 [PubMed - as supplied by publisher]

Comprehensive analysis of parotid mass: A retrospective study of 369 cases.

Fetched: October 18th, 2018, 5:00am GMT

Comprehensive analysis of parotid mass: A retrospective study of 369 cases.

Auris Nasus Larynx. 2018 Apr;45(2):320-327

Authors: Comoglu S, Ozturk E, Celik M, Avci H, Sonmez S, Basaran B, Kiyak E

Abstract
OBJECTIVE: To present the results of patients who underwent superficial or total parotidectomy because of parotid gland tumors in our tertiary care clinic.
METHODS: The data of 362 patients who underwent parotid surgery from January 2008 to November 2015 were collected and analyzed in demographic, histopathological features, and complications.
RESULTS: Three hundred sixty-nine cases (performed in 359 patients) were analyzed and we assessed complications of parotid surgery such as transient or permanent facial paralysis and Frey's syndrome. Pleomorphic adenomas and Warthin's tumors consisted 74% of all parotid gland tumors. These tumors were generally located in the superficial lobe and tail of the parotid gland (81%). Also, tumor size in the positive surgical margin group was larger than in the negative surgical margin group (p=0.012).
CONCLUSIONS: Most of parotid gland tumors are benign. However, the frequency of malignancy increases in deep lobe of parotid gland. High grade malignant tumors have more tendency to have positive surgical margin during surgery, and facial paresis preoperatively.

PMID: 28473271 [PubMed - indexed for MEDLINE]

Permalink for 'Primary acinic cell carcinoma of the breast: A case report with a clinicopathological and immunohistochemical study of a rare breast cancer subtype.'

Primary acinic cell carcinoma of the breast: A case report with a clinicopathological and immunohistochemical study of a rare breast cancer subtype.

Fetched: October 13th, 2018, 5:00am GMT

Primary acinic cell carcinoma of the breast: A case report with a clinicopathological and immunohistochemical study of a rare breast cancer subtype.

Ann Med Surg (Lond). 2018 Nov;35:137-140

Authors: Sen R, Bhutani N, Kamboj J, Dahiya S

Abstract
Acinic cell carcinoma (ACC) of the breast is extremely rare subtype of triple-negative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. Herein, we report a case of acinic cell carcinoma of the breast in a 41-year old female presenting with a palpable breast mass along with significant morphological and immunohistochemical findings. Histologically, ACC showed a diffuse glandular infiltrative pattern, with small acinar or glandular structures mixed with solid nests. Both glandular and solid tumor cell populations were strongly positive for lysozyme. The immunohistochemical profile of the tumor was also similar to that of salivary gland acinic cell carcinoma. She received postoperative chemoradiation therapy and has been doing well. As studies on large series are lacking, further studies are needed to elucidate the biological characteristics of acinic cell carcinoma of the breast. In this study, we perform a detailed morphologic and immunohistochemical description of cases of this rare entity and undertake a comprehensive review of all reported cases of breast acinic cell carcinoma in the English language literature to date.

PMID: 30305896 [PubMed]

Prevention of pancreatic acinar cell carcinoma by Roux-en-Y Gastric Bypass Surgery.

Fetched: October 13th, 2018, 5:00am GMT

Prevention of pancreatic acinar cell carcinoma by Roux-en-Y Gastric Bypass Surgery.

Nat Commun. 2018 Oct 10;9(1):4183

Authors: He R, Yin Y, Yin W, Li Y, Zhao J, Zhang W

Abstract
Roux-en-Y Gastric Bypass Surgery (RYGB) prevents the occurrence of pancreatic cell acinar carcinoma (ACC) in male and female Ngn3-Tsc1-/- mice. Ngn3 directed Cre deletion of Tsc1 gene induced the development of pancreatic ACC. The transgenic mice with sham surgery demonstrated a cancer incidence of 96.7 ± 3.35% and survival rate of 67.0 ± 1.4% at the age of 300 days. Metastasis to liver and kidney was observed in 69.7 ± 9.7% and 44.3 ± 8.01% of these animals, respectively. All animals with RYGB performed at the age of 16 weeks survived free of pancreatic ACC up to the age of 300 days. RYGB significantly attenuated the activation of mTORC1 signaling and inhibition of tumor suppressor genes: p21, p27, and p53 in pancreatic ACC. Our studies demonstrate that bariatric surgery may limit the occurrence and growth of pancreatic ACC through the suppression of mTORC1 signaling in pancreas. RYGB shows promise for intervention of both metabolic dysfunction and organ cancer.

PMID: 30305629 [PubMed - in process]

[Multiple primary neoplasia of kidney, prostate and colon].

Fetched: October 7th, 2018, 5:00am GMT

[Multiple primary neoplasia of kidney, prostate and colon].

Khirurgiia (Mosk). 2018;(4):98-100

Authors: Gallyamov EA, Agapov MA, Kubyshkin VA, Biktimirov RG, Malakhov PS, Zryanin AM, Kamalov AA, Lutsevich OE

PMID: 29697693 [PubMed - indexed for MEDLINE]

PD-L1 Expression in Non-Small-Cell Lung Cancer Including Various Adenocarcinoma Subtypes.

Fetched: October 6th, 2018, 5:00am GMT

PD-L1 Expression in Non-Small-Cell Lung Cancer Including Various Adenocarcinoma Subtypes.

Ann Thorac Cardiovasc Surg. 2018 Oct 03;:

Authors: Miyazawa T, Marushima H, Saji H, Kojima K, Hoshikawa M, Takagi M, Nakamura H

Abstract
PURPOSE: Knowledge regarding programmed death-ligand 1 (PD-L1) expression in lung cancer is limited. We aim to clarify PD-L1-positive expression in non-small-cell lung cancer (NSCLC), including adenocarcinoma subtypes.
METHODS: In all, 90 NSCLC specimens containing various adenocarcinoma subtypes, in addition to squamous cell carcinoma and large-cell carcinoma were selected. PD-L1 was immunohistochemically stained by murine monoclonal antibody clone 22C3.
RESULTS: When PD-L1-positive expression was defined by tumor proportion score (TPS) ≥1%, the positive cases were 0/11 in adenocarcinoma in situ, 0/12 in minimally invasive adenocarcinoma, 1/10 in lepidic predominant adenocarcinoma, 1/13 in papillary predominant adenocarcinoma, 8/14 in acinar predominant adenocarcinoma, 6/11 in solid predominant adenocarcinoma, 0/3 in micropapillary predominant adenocarcinoma, 0/4 in invasive mucinous adenocarcinoma, 4/9 in squamous cell carcinoma, and 2/3 in large-cell carcinoma. PD-L1 positivity was higher in males, smokers, advanced pathologic stages, positive vessel invasion, and positive lymphatic invasion. Postoperative survival analysis revealed that PD-L1-positive expression was a significantly worse prognostic factor in univariate analysis for recurrence-free survival (RFS).
CONCLUSION: PD-L1-positive tumors were frequent in acinar predominant adenocarcinoma and solid predominant adenocarcinoma than other adenocarcinoma subtypes. PD-L1 expression seemed to increase according to pathologic tumor progression, suggesting a worse postoperative prognosis in NSCLC patients.

PMID: 30282880 [PubMed - as supplied by publisher]

Permalink for 'Alveolar architectures preserved in cancer tissues may be potential pitfalls for diagnosis and histological subtyping of lung cancer: Three case reports.'

Alveolar architectures preserved in cancer tissues may be potential pitfalls for diagnosis and histological subtyping of lung cancer: Three case reports.

Fetched: October 5th, 2018, 5:00am GMT

Alveolar architectures preserved in cancer tissues may be potential pitfalls for diagnosis and histological subtyping of lung cancer: Three case reports.

Medicine (Baltimore). 2018 Sep;97(39):e12613

Authors: Fan X, Zhang X, Wang E, Fan C

Abstract
RATIONALE: Lung cancer is a leading cause of cancer-related deaths globally. Appropriate histopathological diagnosis and subtyping form the basis and are critical for clinical therapies.
PATIENT CONCERNS: Here, we report about 3 patients who had a nodule in the lung. Cancer cells grow in the alveolar cavity in many lung carcinomas. In all our 3 cases preserved alveolar architectures were found in tumor tissues which may lead to diagnostic pitfalls.
DIAGNOSES: Three patients had tumors that were diagnosed as nonsmall cell lung cancers, including large-cell carcinoma, peripheral squamous cell carcinoma, and large-cell neuroendocrine carcinoma, all of which contained structures of preserved alveolar cells that could be mistaken as malignant glandular components. The preserved alveolar cells formed acinar or duct-like structures enwrapped in the lung cancer tissues or surrounded the nests of cancer cells. Proliferative alveolar cells adjacent to cancer tissues were observed, and papillary structures and marked atypia, both of which may be mistaken as part of adenocarcinoma or carcinoma with glandular differentiation, were also observed.
INTERVENTIONS: All patients underwent surgery and postoperative chemotherapy.
OUTCOMES: The patients had no recurrence at 5-, 8-, or 10-month follow-up after the last surgery.
LESSONS: Preserved alveolar cells with different architectures may be observed in various lung cancer tissues and may be mistaken as adenocarcinoma or carcinoma with glandular differentiation. Distinct morphological and immunohistochemical features may help distinguish preserved alveolar cells from tumor components.

PMID: 30278581 [PubMed - in process]

Permalink for 'The Squamous Cells of Adenosquamous Carcinoma (ASCC) of the Prostate Might Represent a Terminally Differentiated Quiescent Component: Immunohistochemical Evidence From a Case of ASCC With Pleomorphic Giant Tumor Cells.'

The Squamous Cells of Adenosquamous Carcinoma (ASCC) of the Prostate Might Represent a Terminally Differentiated Quiescent Component: Immunohistochemical Evidence From a Case of ASCC With Pleomorphic Giant Tumor Cells.

Fetched: September 21st, 2018, 5:00am GMT

The Squamous Cells of Adenosquamous Carcinoma (ASCC) of the Prostate Might Represent a Terminally Differentiated Quiescent Component: Immunohistochemical Evidence From a Case of ASCC With Pleomorphic Giant Tumor Cells.

Appl Immunohistochem Mol Morphol. 2017 09;25(8):e71-e73

Authors: Acosta AM, Kajdacsy-Balla A, Groth JV

PMID: 27753662 [PubMed - indexed for MEDLINE]

Permalink for 'MR imaging features of mammary analogue secretory carcinoma and acinic cell carcinoma of the salivary gland: a preliminary report.'

MR imaging features of mammary analogue secretory carcinoma and acinic cell carcinoma of the salivary gland: a preliminary report.

Fetched: September 20th, 2018, 5:00am GMT

MR imaging features of mammary analogue secretory carcinoma and acinic cell carcinoma of the salivary gland: a preliminary report.

Dentomaxillofac Radiol. 2018 Jul;47(5):20170218

Authors: Kashiwagi N, Nakatsuka SI, Murakami T, Enoki E, Yamamoto K, Nakanishi K, Chikugo T, Kurisu Y, Kimura M, Hyodo T, Tsukabe A, Kakigi T, Tomita Y, Ishii K, Narumi Y, Yagyu Y, Tomiyama N

Abstract
OBJECTIVES: To report MR imaging features of mammary analogue secretory carcinoma (MASC) and acinic cell carcinoma (AciCC) of the salivary gland based on the latest version of the World Health Organization (WHO) 2017 classification of head and neck tumours.
METHODS: MR images in 4 patients with MASC and 4 with AciCC were reviewed for margin characteristics, the presence of pathological cervical nodes, the presence of a cystic component and interface between cystic and solid component, signal intensity of the cystic components on T1 weighted images, and signal intensity of the solid component on T1 and T2 weighted images.
RESULTS: All the MASCs and AciCCs had well-defined boundaries, and 1 AciCC had pathological nodes. All 4 MASCs presented as predominantly cystic tumours with papillary projection of the solid component. All 4 AciCCs presented as solid tumours. The signal intensity of the cystic components on T1 weighted images was entirely hyperintense in 2, and partly hyperintense demonstrating fluid-fluid level in 2. In all the MASCs, the signal intensity of the solid components on T1 weighted images was intermediate. In the AciCCs, the signal intensity of the solid components on T1 weighted images was high in 2 tumours and intermediate in 2. The signal intensity of the solid components on T2 weighted images varied from low to high in both MSACs and AciCCs.
CONCLUSIONS: All 4 MASCs had a large cystic component, including areas of high signal intensity on T1 weighted images. The solid component appeared as a papillary projection into the cystic component. All 4 AciCCs presented as solid tumours, 2 of which showed high signal intensity on T1 weighted images.

PMID: 29493279 [PubMed - indexed for MEDLINE]

So-called acinic cell carcinoma of the breast arises from microgladular adenosis and is not a distinct entity.

Fetched: September 16th, 2018, 5:00am GMT

So-called acinic cell carcinoma of the breast arises from microgladular adenosis and is not a distinct entity.

Mod Pathol. 2017 10;30(10):1504

Authors: Rosen PP

PMID: 28972583 [PubMed - indexed for MEDLINE]

[Pediatric salivary gland tumors and tumor-like lesions].

Fetched: August 31st, 2018, 5:00am GMT

[Pediatric salivary gland tumors and tumor-like lesions].

Pathologe. 2017 Jul;38(4):294-302

Authors: Agaimy A, Iro H, Zenk J

Abstract
Salivary gland tumors and tumor-like lesions in the pediatric population are uncommon. They comprise a heterogeneous group of infectious/inflammatory and neoplastic conditions. Pediatric salivary neoplasms include benign tumors of mesenchymal or epithelial origin as well as malignancies of epithelial (carcinomas), mesenchymal (sarcoma) or hematolymphoid (lymphoma) derivation. Infectious/inflammatory conditions and hematolymphoid malignancies may represent either genuine parenchymal pathology or conditions involving intraglandular lymph nodes of the parotid glands (intraglandular lymphadenopathy and intraglandular nodal lymphomas). Pediatric sialadenitis may be of diverse etiologies including viral (mumps, CMV, HIV, etc.), bacterial, autoimmune (juvenile Sjögren syndrome) or idiopathic (chronic recurrent juvenile sialectatic sialadenitis). Angiomatous lesions (juvenile capillary hemangioma, lymphangioma and vascular malformation) and pleomorphic adenomas represent the most common pediatric benign mesenchymal and benign epithelial tumors, respectively. The vast majority of salivary gland carcinomas in children and adolescents represent low-grade mucoepidermoid carcinomas followed by acinic cell and adenoid cystic carcinomas (together >80% of carcinomas). Other malignant neoplasms include (rhabdomyo-) sarcomas, malignant lymphomas and very rarely sialoblastomas. This long differential diagnosis list of etiologically and biologically highly heterogeneous entities, their shared clinical presentation as "salivary gland enlargement" and the significant differences in their therapeutic strategies and prognosis underline the need for careful assessment to identify the correct diagnosis. Diagnosis is mainly based on a set of typical clinical and imaging features, serological/microbiological findings and, in selected cases, histomorphological characteristics in biopsy specimens.

PMID: 28597093 [PubMed - indexed for MEDLINE]

Permalink for 'Indolent T-lymphoblastic proliferation concomitant with acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review.'

Indolent T-lymphoblastic proliferation concomitant with acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review.

Fetched: August 30th, 2018, 5:00am GMT

Indolent T-lymphoblastic proliferation concomitant with acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review.

Histopathology. 2018 Apr;72(5):862-866

Authors: Yasuda H, Tsutsui M, Ota Y, Tanaka M, Komatsu N

Abstract
AIMS: Indolent T-lymphoblastic proliferation (iT-LBP) is a non-clonal benign condition showing extrathymic proliferation of T-lymphoblasts positive for CD3, CD4, CD8, and TdT. Isolated iT-LBP has been observed, but the majority of iT-LBPs have been seen in conjunction with other disorders, including Castleman disease, hepatocellular carcinoma, follicular dendritic cell tumours, angioimmunoblastic T-cell lymphoma, myasthenia gravis, and acinic cell carcinoma (ACC). The clinical course of iT-LBP is indolent, and no therapy is usually required. A major concern is misdiagnosis as T-lymphoblastic lymphoma, and a correct diagnosis of iT-LBP often requires not only pathological analysis but also careful monitoring of the clinical course. The aim of this study was to broaden the knowledge of pathologists and physicians concerning this as yet not well-recognised entity.
METHODS AND RESULTS: We report a case of iT-LBP concomitant with ACC, along with a literature review of all 14 cases of iT-LBP reported to date.
CONCLUSIONS: iT-LBP should always be considered as a differential diagnosis of T-lymphoblastic lymphoma, as the two disorders show extremely similar traits.

PMID: 29143359 [PubMed - indexed for MEDLINE]

Permalink for 'High grade adenocarcinoma in the ectopic prostate accompanied by a low grade adenocarcinoma in the orthotopic prostate: an unusual diagnostic pitfall.'

High grade adenocarcinoma in the ectopic prostate accompanied by a low grade adenocarcinoma in the orthotopic prostate: an unusual diagnostic pitfall.

Fetched: August 26th, 2018, 5:00am GMT

High grade adenocarcinoma in the ectopic prostate accompanied by a low grade adenocarcinoma in the orthotopic prostate: an unusual diagnostic pitfall.

Pathology. 2017 Oct;49(6):665-668

Authors: Tolkach Y, Ellinger J, Müller S, Kristiansen G

PMID: 28830691 [PubMed - indexed for MEDLINE]

Pancreatic acinar cell carcinoma-induced panniculitis.

Fetched: August 23rd, 2018, 5:00am GMT

Pancreatic acinar cell carcinoma-induced panniculitis.

JAAD Case Rep. 2018 Aug;4(7):719-721

Authors: Singh S, Gorouhi F, Konia T, Burrall B

PMID: 30128347 [PubMed]

Prognostic value of epidermal growth factor receptor mutations and histologic subtypes with lung adenocarcinoma.

Fetched: August 19th, 2018, 5:00am GMT

Prognostic value of epidermal growth factor receptor mutations and histologic subtypes with lung adenocarcinoma.

Med Oncol. 2018 Jan 31;35(3):22

Authors: Motono N, Funasaki A, Sekimura A, Usuda K, Uramoto H

Abstract
The epidermal growth factor receptor (EGFR) mutation status has become one of the most important factors in the treatment of non-small cell lung cancer. However, the relationship between EGFR mutation and the histologic subtype of lung adenocarcinoma remains to be fully elucidated. We examined the relationship between the predominant subtype of adenocarcinoma and the prognosis and investigated the correlation between a new subtype of adenocarcinoma and EGFR mutations. This study included 182 patients with adenocarcinoma who underwent complete resection. The rate of EGFR mutation-positive patients was significantly higher among female patients, never smokers, patients with small tumors (< 3 cm in size), patients with well-differentiated tumors, and patients with a pStage I classification. The rates of adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and lepidic-predominant subtype were high in male EGFR mutation-positive patients. The prevalence of the acinar and papillary-predominant subtypes was high among EGFR mutation-positive female patients, as was AIS, MIA, and the lepidic-predominant subtype. The progression-free survival (PFS) of the EGFR mutation-positive patients was significantly better than that of the EGFR mutation-negative patients (75.8 vs 67.1%, p = 0.03). However, the multivariate analysis of clinicopathologic and histologic factors did not reveal the prognostic impact of the EGFR mutation status on PFS. The overall survival (OS) of the EGFR mutation-positive patients was significantly better than that of the EGFR mutation-negative patients (93.7 vs 63.4%, p < 0.01). However, in the multivariate analysis the EGFR mutation status was not significantly associated with OS.

PMID: 29387978 [PubMed - indexed for MEDLINE]

Permalink for '[Clinicopatholigic features of renal cell carcinoma associated with chromosome X inversion harboring gene fusions involving TFE3].'

[Clinicopatholigic features of renal cell carcinoma associated with chromosome X inversion harboring gene fusions involving TFE3].

Fetched: August 17th, 2018, 5:00am GMT

[Clinicopatholigic features of renal cell carcinoma associated with chromosome X inversion harboring gene fusions involving TFE3].

Zhonghua Bing Li Xue Za Zhi. 2018 Aug 08;47(8):574-579

Authors: Zhao YN, Wang XT, Xia QY, Wang GP, Sun SY, Zhao LF, Zhou XJ, Rao Q

Abstract
Objective: To study the clinicopathologic features, immunophenotype, characteristic FISH pattern and prognosis of renal cell carcinoma (RCC) associated with chromosome X inversion harboring gene fusions involving TFE3. Methods: Ten cases of NONO-TFE3 RCC and four cases of RBM10-TFE3 RCC were investigated at Nanjing Jinling Hospital from 2009 to 2016 by clinicopathological findings, immunohistochemistry, and genetic analysis. Results: Morphologically, the distinct pattern of secretory endometrioid subnuclear vacuolization was overlapped with clear cell papillary RCC, and often accompanied by sheets of epithelial cells in NONO-TFE3 RCC. Most cases of RBM10-TFE3 RCC presented with the biphasic feature that acinar, tubular and papillary patterns of epithelioid cells combined with sheets of small cells with "pseudorosette-like" architectures. In addition, cytoplasmic vacuolization, nuclear groove, and psammoma bodies were also observed. Immunohistochemically, all NONO-TFE3 RCC cases were immunoreactive for TFE3, CD10, RCC markers, and PAX8, and negative for CK7, Cathepsin K, Melan A, HMB45, Ksp-cadherin, vimentin, and CD117. All 4 cases of RBM10-TFE3 RCC showed moderate to strong immunoreactivity for TFE3, Cathepsin K, CD10, Ksp-cadherin, E-cadherin, P504s, RCC marker, PAX8, and vimentin but negative for TFEB, HMB45 and CK7. CKpan and Melan A were at least focally expressed. The antibody to Ki-67 showed labeling of 3%-8% (mean 5%). There were some expression discrepancies of immunochemistry between different histological patterns. PAX8, CKpan, P504s, and Ksp-cadherin were expressed in epithelioid areas but not in small-cell areas. Ki-67 labeling index of epithelioid areas was higher than that in small-cell areas. In molecular analysis, NONO-TFE3 fusion transcripts were identified in 6 patients. The fusion points were between exon 7 of NONO and exon 6 of TFE3 in 5 patients and between exon 9 of NONO and exon 5 of TFE3 in one patient. All 4 cases of RBM10-TFE3 RCC demonstrated to have RBM10-TFE3 fusion transcripts and the fusion points were between exon 5 of TFE3 and exon 17 of RBM10. Using TFE3 break-apart FISH assay, all 10 cases of NONO-TFE3 RCC showed characteristic patterns of equivocal split signals with a distance of nearly 2 signal diameters. All 4 cases of RBM10-TFE3 RCC showed colocalized or subtle split signals with a distance of <1 signal diameter, which was considered as negative results. Long-term follow-up was available for 7 patients of NONO-TFE3 RCC and 4 patients of RBM10-TFE3 RCC. All patients were alive with no evidence of disease. Conclusions: Two rare genotypes, NONO-TFE3 RCC and RBM10-TFE3 RCC, are reported in this study. Both of these two tumors show specific morphology and good prognosis, along with the positive TFE3 staining and the equivocal or false-negative TFE3 FISH results, which could be missed. PCR detection or next-generation sequencing can determine the genotype.

PMID: 30107660 [PubMed - in process]

Pancreatic Acinar Cell Carcinoma with Multiple Liver Metastases Effectively Treated by S-1 Chemotherapy.

Fetched: August 15th, 2018, 5:00am GMT

Pancreatic Acinar Cell Carcinoma with Multiple Liver Metastases Effectively Treated by S-1 Chemotherapy.

Intern Med. 2018 Aug 10;:

Authors: Yoshida N, Kanno A, Masamune A, Nabeshima T, Hongo S, Miura S, Takikawa T, Hamada S, Kikuta K, Kume K, Ueno M, Shimosegawa T

Abstract
A 79-year-old woman was referred for pancreatic tail cancer with multiple liver metastases. The pancreatic tail tumor was diagnosed as acinar cell carcinoma (ACC) histologically by endoscopic ultrasound-guided fine-needle aspiration. Because of multiple liver metastases, S-1 chemotherapy was administered, resulting in a partial response to chemotherapy one year later. After approximately three years, liver atrophy and esophageal varices developed. We suspected S-1 as the cause of the liver cirrhosis. S-1 cessation minimized ascites and improved the esophageal varices. Although S-1 can potentially treat ACC, we should be watchful for liver cirrhosis caused by its long-term administration.

PMID: 30101903 [PubMed - as supplied by publisher]

Pancreatic Mass in a Patient With an Increased Serum Level of IgG4.

Fetched: August 10th, 2018, 5:00am GMT

Pancreatic Mass in a Patient With an Increased Serum Level of IgG4.

Gastroenterology. 2018 08;155(2):269-270

Authors: Matsumori T, Shiokawa M, Kodama Y

PMID: 29410043 [PubMed - indexed for MEDLINE]

[Clinicopathologic and molecular genetic analysis of secretory carcinoma of salivary gland].

Fetched: August 9th, 2018, 5:00am GMT

[Clinicopathologic and molecular genetic analysis of secretory carcinoma of salivary gland].

Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 Aug 09;53(8):533-538

Authors: Zhao M, Zhao DH, Cheng G, Yan YJ, Wang Z, He XL

Abstract
Objective: To investigate the clinicopathologic and molecular genetic features of secretory carcinoma of salivary gland (SCSG). Methods: Six cases of SCSG were collected from Zhejiang Provincial People's Hospital from January 2011 to March 2018. The clinical, histopathological and immunohistochemical features were analyzed and fluorescence in situ hybridization (FISH) was used to detect ETV6 gene rearrangement. Results: Four out of 6 tumors originated in the parotid gland and one of each in the minor salivary glands of soft palate and the buccal mucosa. Grossly, 4 cases were solid and 2 were partially cystic with maximum diameter ranging from 1.0 to 4.0 cm. Microscopically, 5 tumors showed typical features of low grade SCSG with tumor divided by thin fibrous septa into lobules composed of solid acinar, microcystic, follicular and papillary structures with abundant extracellular mucinous secretions. The tumor cells had cuolated or hobnail cytoplasm with low-grade nuclei and scarce mitoses. Perineural invasion was present in 1 case. The remaining tumor showed about 30% of the tumor areas with high-grade transformation characterized by proliferation of a distinct population of anaplastic cells arranged in irregular glandular, small nested and single cell patterns that were surrounded by desmoplastic stroma and invaded into surface mucosa with ulceration. Immunohistochemistry showed that all 6 tumors had diffuse and strong reactivities to S100 protein and cytokeratin 7, and 4 cases showed focal reactivity to gross cystic disease fluid protein 15 (GCDFP15), all were negative for discovered on gist 1 (DOG1), cytokeratin 20, p63 and calponin. High grade transformation cases were analysed, the high grade SCSG components showed a significantly increased Ki-67 index and cyclin D1 positive tumor cells compared to the conventional SCSG components. FISH analyses showed that 4 cases had ETV6 gene rearrangement. Eleven to seventy one months' follow-up showed no evidence of tumor recurrence nor metastasis. Conclusions: SCSG harbors characteristic genetic abnormalities with ETV6 gene rearrangement and typically shows a low grade morphology with occasionally, high grade transformation can be present.

PMID: 30078266 [PubMed - in process]

Acinic cell carcinoma of minor salivary glands - case report.

Fetched: August 9th, 2018, 5:00am GMT

Acinic cell carcinoma of minor salivary glands - case report.

Rom J Morphol Embryol. 2017;58(3):1003-1007

Authors: Buhaş CL, Roşca E, MuŢiu G, Venter AC, Buhaş BA, CouŢi R, Ciobanu CF, Roşca DM

Abstract
Salivary gland tumors have a high incidence (90%) within the parotid gland. The acinic cell carcinoma (ACC) represents only 1-3% of the salivary gland tumors, most frequently affecting the parotid. The minor salivary glands rarely develop ACC and when the ACC is localized in these glands, generally, it has a less aggressive evolution. The main criterion in the diagnostic of ACC is the histological examination with the regular Hematoxylin-Eosin (HE) staining and additionally Periodic Acid-Schiff (PAS) special staining. Immunohistochemical (IHC) examination confirms the origin of the tumor cells and the cellular proliferation index. Therapeutic management consists of surgical excision and radiotherapy. Left jugular tumor was the clinical diagnosis in the case we presented. The computed tomography (CT) examination revealed a voluminous expansive process of the left cheek. Surgery was performed with tumor resection and the skin defect was threatened. The histopathological (HP) and IHC exams have established the diagnosis of minor salivary glands adenocarcinoma with increased tumor proliferation index. The evolution was unfavorable to tumor recurrence in a short time of one year.

PMID: 29250681 [PubMed - indexed for MEDLINE]

Surgical resection of hepatic and rectal metastases of pancreatic acinar cell carcinoma (PACC): a case report.

Fetched: August 7th, 2018, 5:00am GMT

Surgical resection of hepatic and rectal metastases of pancreatic acinar cell carcinoma (PACC): a case report.

World J Surg Oncol. 2018 Aug 03;16(1):158

Authors: Ohara Y, Oda T, Enomoto T, Hisakura K, Akashi Y, Ogawa K, Owada Y, Domoto Y, Miyazaki Y, Shimomura O, Kurata M, Ohkohchi N

Abstract
BACKGROUND: Pancreatic acinar cell carcinoma (PACC), a rare variant of pancreatic malignancy, is generally managed the same way as pancreatic ductal adenocarcinoma (PDAC). Surgical resection is the gateway to curing it; however, once it metastasizes (usually to the liver, lungs, lymph nodes, or peritoneal cavity), systemic chemotherapy has been the only option, but with unfavorable results.
CASE PRESENTATION: A 67-year-old man with symptoms of loss of appetite and weight underwent surgery for malignancy of the pancreatic tail extending into the entire pancreas. The pathological diagnosis was PACC following total pancreatectomy. Twenty-four months after the pancreatectomy, a solitary liver metastasis was treated by partial hepatectomy, and, subsequently, 4 months later, he presented with melena. Further examination revealed a type-2 rectal tumor. Histological examination following biopsy revealed it to be rectal metastasis of PACC, and it was treated by abdominoperineal resection. Subsequently, the patient did not have tumor recurrence as of 40 months after pancreatectomy.
CONCLUSIONS: This is a rare case of PACC presenting with metachronal metastases in the liver and rectum, and we successfully treated them by surgical resections. Since the malignant behavior of PACC is usually less than that of PDAC, surgical resection could be an option even for metastatic lesions when the number and extent of metastases are limited.

PMID: 30075727 [PubMed - in process]

Acelarin First Line Randomised Pancreatic Study

Posted: August 1st, 2018, 2:00pm GMT

Conditions: Pancreatic Acinar Carcinoma; Pancreatic Neoplasms
Interventions: Drug: Acelarin; Drug: Gemcitabine
Sponsors: The Clatterbridge Cancer Centre NHS Foundation Trust; Cancer Research UK; University of Liverpool
Recruiting

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

Posted: July 15th, 2016, 2:00pm GMT

Conditions: Acinar Cell Carcinoma; Adenoid Cystic Carcinoma; Adrenal Cortex Carcinoma; Adrenal Gland Pheochromocytoma; Anal Canal Neuroendocrine Carcinoma; Anal Canal Undifferentiated Carcinoma; Appendix Mucinous Adenocarcinoma; Bartholin Gland Transitional Cell Carcinoma; Bladder Adenocarcinoma; Cervical Adenocarcinoma; Cholangiocarcinoma; Chordoma; Colorectal Squamous Cell Carcinoma; Desmoid-Type Fibromatosis; Endometrial Transitional Cell Carcinoma; Endometrioid Adenocarcinoma; Esophageal Neuroendocrine Carcinoma; Esophageal Undifferentiated Carcinoma; Extrahepatic Bile Duct Carcinoma; Fallopian Tube Adenocarcinoma; Fallopian Tube Transitional Cell Carcinoma; Fibromyxoid Tumor; Gastric Neuroendocrine Carcinoma; Gastric Squamous Cell Carcinoma; Gastric Undifferentiated Carcinoma; Gastrointestinal Stromal Tumor; Giant Cell Carcinoma; Intestinal Neuroendocrine Carcinoma; Intrahepatic Cholangiocarcinoma; Lung Carcinoid Tumor; Lung Sarcomatoid Carcinoma; Major Salivary Gland Carcinoma; Malignant Odontogenic Neoplasm; Malignant Peripheral Nerve Sheath Tumor; Malignant Testicular Sex Cord-Stromal Tumor; Metaplastic Breast Carcinoma; Metastatic Malignant Neoplasm of Unknown Primary Origin; Minimally Invasive Lung Adenocarcinoma; Mixed Mesodermal (Mullerian) Tumor; Mucinous Adenocarcinoma; Mucinous Cystadenocarcinoma; Nasal Cavity Adenocarcinoma; Nasal Cavity Carcinoma; Nasopharyngeal Carcinoma; Nasopharyngeal Papillary Adenocarcinoma; Nasopharyngeal Undifferentiated Carcinoma; Oral Cavity Carcinoma; Oropharyngeal Undifferentiated Carcinoma; Ovarian Adenocarcinoma; Ovarian Germ Cell Tumor; Ovarian Mucinous Adenocarcinoma; Ovarian Squamous Cell Carcinoma; Ovarian Transitional Cell Carcinoma; Pancreatic Acinar Cell Carcinoma; Pancreatic Neuroendocrine Carcinoma; Paraganglioma; Paranasal Sinus Adenocarcinoma; Paranasal Sinus Carcinoma; Parathyroid Gland Carcinoma; Pituitary Gland Carcinoma; Placental Choriocarcinoma; Placental-Site Gestational Trophoblastic Tumor; Primary Peritoneal High Grade Serous Adenocarcinoma; Pseudomyxoma Peritonei; Rare Disorder; Scrotal Squamous Cell Carcinoma; Seminal Vesicle Adenocarcinoma; Seminoma; Serous Cystadenocarcinoma; Small Intestinal Adenocarcinoma; Small Intestinal Squamous Cell Carcinoma; Spindle Cell Neoplasm; Squamous Cell Carcinoma of the Penis; Teratoma With Malignant Transformation; Testicular Non-Seminomatous Germ Cell Tumor; Thyroid Gland Carcinoma; Tracheal Carcinoma; Transitional Cell Carcinoma; Ureter Adenocarcinoma; Ureter Squamous Cell Carcinoma; Urethral Adenocarcinoma; Urethral Squamous Cell Carcinoma; Vaginal Adenocarcinoma; Vaginal Squamous Cell Carcinoma, Not Otherwise Specified; Vulvar Carcinoma
Interventions: Procedure: Biospecimen Collection; Biological: Ipilimumab; Biological: Nivolumab
Sponsor: National Cancer Institute (NCI)
Recruiting

Permalink for 'High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery'

High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery

Posted: May 2nd, 2016, 2:00pm GMT

Conditions: Acinar Cell Carcinoma; Ampulla of Vater Adenocarcinoma; Cholangiocarcinoma; Duodenal Adenocarcinoma; Pancreatic Adenocarcinoma; Pancreatic Ductal Adenocarcinoma; Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type; Periampullary Adenocarcinoma
Interventions: Procedure: Pancreatectomy; Other: Lavage
Sponsor: Sidney Kimmel Cancer Center at Thomas Jefferson University
Recruiting

Stereotactic Radiosurgery and Metformin in Patients With Borderline-Resectable or Locally-Advanced Pancreatic Cancer

Posted: June 3rd, 2014, 2:00pm GMT

Conditions: Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage I-III Pancreatic Cancer
Interventions: Drug: metformin hydrochloride; Radiation: stereotactic radiosurgery
Sponsors: Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting

This RSS feed URL is deprecated

Posted: August 30th, 2018, 5:00am GMT

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Acinic Cell Carcinoma - News-Medical.net

Posted: June 20th, 2018, 11:28pm GMT

News-Medical.net

The Spectrum of Triple-Negative Breast Disease - Am J Pathology

Posted: July 21st, 2017, 10:03pm GMT

Am J Pathology

The Spectrum of Triple-Negative Breast Disease
Am J Pathology
Whereas fairly common in acinic cell carcinoma, it is a rare event in the salivary gland–like tumors of the breast and solid papillary carcinoma with reverse polarity. ∗It should be noted that evidence for the presence of PRKD1 E710D mutations or PRKD1 ...

Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype - Nature.com

Posted: August 20th, 2015, 7:27am GMT

Nature.com

Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype
Nature.com
Diegel, C. R., Cho, K. R., El-Naggar, A. K., Williams, B. O. & Lindvall, C. Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma ...

Orthopedics - Healio

Posted: April 27th, 2014, 8:30pm GMT

Orthopedics
Healio
Four-Year Survival of a Patient With Spinal Metastatic Acinic Cell Carcinoma After a Total En Bloc Spondylectomy and Reconstruction With a Frozen Tumor-Bearing Bone Graft. Orthopedics, September/October 2018, Volume 41 Issue 5. Acinic cell carcinoma ...

Clinicopathological analysis of programmed death-ligand 1 testing in tumor cells of 325 patients with non-small cell lung cancer: Its predictive and potential prognostic value.

Fetched: November 19th, 2018, 5:00am GMT

Clinicopathological analysis of programmed death-ligand 1 testing in tumor cells of 325 patients with non-small cell lung cancer: Its predictive and potential prognostic value.

Cesk Patol. 2018;54(3):137-142

Authors: Farkašová A, Tancoš V, Kviatkovská Z, Huťka Z, Mičák J, Scheerová K, Szépe P, Plank L

PMID: 30445818 [PubMed - in process]

Pancreatic acinar cell carcinoma-case report and literature review.

Fetched: November 11th, 2018, 5:00am GMT

Pancreatic acinar cell carcinoma-case report and literature review.

BMC Cancer. 2018 Nov 08;18(1):1083

Authors: Xing-Mao Z, Hong-Juan Z, Qing L, Qiang H

PMID: 30409114 [PubMed - in process]

Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib: A case report.

Fetched: November 10th, 2018, 5:00am GMT

Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib: A case report.

Medicine (Baltimore). 2018 Nov;97(45):e13113

Authors: Li M, Mou Y, Hou S, Cao D, Li A

PMID: 30407325 [PubMed - in process]

[Visually Isoattenuating Pancreatic Acinar Cell Carcinoma:Report of One Case].

Fetched: November 10th, 2018, 5:00am GMT

[Visually Isoattenuating Pancreatic Acinar Cell Carcinoma:Report of One Case].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2018 Oct 30;40(5):714-718

Authors: Li J, Chang XY, Zhu L, Dai MH, Xue HD

PMID: 30404708 [PubMed - in process]

Unusual gastric subepithelial tumor: primary mixed acinar-endocrine neoplasm in an anemic woman.

Fetched: November 8th, 2018, 5:00am GMT

Unusual gastric subepithelial tumor: primary mixed acinar-endocrine neoplasm in an anemic woman.

Gastrointest Endosc. 2018 May;87(5):1355-1356

Authors: Uraizee I, Hart J, Waxman I, Weber CR, Setia N

PMID: 29102730 [PubMed - indexed for MEDLINE]

Immune infiltrates and PD-L1 expression in treatment-naïve acinar prostatic adenocarcinoma: an exploratory analysis.

Fetched: October 31st, 2018, 5:00am GMT

Immune infiltrates and PD-L1 expression in treatment-naïve acinar prostatic adenocarcinoma: an exploratory analysis.

J Clin Pathol. 2018 Nov;71(11):1023-1027

Authors: Hahn E, Liu SK, Vesprini D, Xu B, Downes MR

PMID: 30257853 [PubMed - indexed for MEDLINE]

A novel experimental model for human mixed acinar-ductal pancreatic cancer.

Fetched: October 27th, 2018, 5:00am GMT

A novel experimental model for human mixed acinar-ductal pancreatic cancer.

Carcinogenesis. 2018 02 09;39(2):180-190

Authors: Doiron B, DeFronzo RA

PMID: 29106450 [PubMed - indexed for MEDLINE]

Potential therapeutic effects of induced pluripotent stem cells on induced salivary gland cancer in experimental rats.

Fetched: October 21st, 2018, 5:00am GMT

Potential therapeutic effects of induced pluripotent stem cells on induced salivary gland cancer in experimental rats.

Biotech Histochem. 2018 Oct 19;:1-8

Authors: Alaa El-Din Y, Sabry D, Abdelrahman AH, Fathy S

PMID: 30338701 [PubMed - as supplied by publisher]

Lung adenocarcinoma with concurrent ALK and ROS1 rearrangement: A case report and review of the literatures.

Fetched: October 19th, 2018, 5:00am GMT

Lung adenocarcinoma with concurrent ALK and ROS1 rearrangement: A case report and review of the literatures.

Pathol Res Pract. 2018 Oct 01;:

Authors: Deng H, Liu C, Zhang G, Wang X, Liu Y

PMID: 30327151 [PubMed - as supplied by publisher]

Multiple simultaneous head and neck cancers in Lynch syndrome: Case report and literature review.

Fetched: October 18th, 2018, 5:00am GMT

Multiple simultaneous head and neck cancers in Lynch syndrome: Case report and literature review.

Laryngoscope. 2018 Oct 16;:

Authors: Feng AL, Le A, Johnson DN, Varvares MA

Abstract
Head and neck cancers account for a significant proportion of reported malignancies in the United States; however, multiple concurrent primary malignancies from different sites are rare. We describe the case of a 44-year-old man simultaneously diagnosed with three independent head and neck malignancies (adenocarcinoma in minor salivary gland, papillary thyroid carcinoma, and acinic cell carcinoma) in the setting of Lynch syndrome. To our knowledge, this is the first case of multiple head and neck malignancies arising simultaneously from Lynch syndrome. This case highlights the need for diligent workup in patients with hereditary conditions that predispose to malignancies. Laryngoscope, 2018.

PMID: 30325023 [PubMed - as supplied by publisher]

Comprehensive analysis of parotid mass: A retrospective study of 369 cases.

Fetched: October 18th, 2018, 5:00am GMT

Comprehensive analysis of parotid mass: A retrospective study of 369 cases.

Auris Nasus Larynx. 2018 Apr;45(2):320-327

Authors: Comoglu S, Ozturk E, Celik M, Avci H, Sonmez S, Basaran B, Kiyak E

PMID: 28473271 [PubMed - indexed for MEDLINE]

Primary acinic cell carcinoma of the breast: A case report with a clinicopathological and immunohistochemical study of a rare breast cancer subtype.

Fetched: October 13th, 2018, 5:00am GMT

Primary acinic cell carcinoma of the breast: A case report with a clinicopathological and immunohistochemical study of a rare breast cancer subtype.

Ann Med Surg (Lond). 2018 Nov;35:137-140

Authors: Sen R, Bhutani N, Kamboj J, Dahiya S

PMID: 30305896 [PubMed]

Prevention of pancreatic acinar cell carcinoma by Roux-en-Y Gastric Bypass Surgery.

Fetched: October 13th, 2018, 5:00am GMT

Prevention of pancreatic acinar cell carcinoma by Roux-en-Y Gastric Bypass Surgery.

Nat Commun. 2018 Oct 10;9(1):4183

Authors: He R, Yin Y, Yin W, Li Y, Zhao J, Zhang W

PMID: 30305629 [PubMed - in process]

[Multiple primary neoplasia of kidney, prostate and colon].

Fetched: October 7th, 2018, 5:00am GMT

[Multiple primary neoplasia of kidney, prostate and colon].

Khirurgiia (Mosk). 2018;(4):98-100

Authors: Gallyamov EA, Agapov MA, Kubyshkin VA, Biktimirov RG, Malakhov PS, Zryanin AM, Kamalov AA, Lutsevich OE

PMID: 29697693 [PubMed - indexed for MEDLINE]

PD-L1 Expression in Non-Small-Cell Lung Cancer Including Various Adenocarcinoma Subtypes.

Fetched: October 6th, 2018, 5:00am GMT

PD-L1 Expression in Non-Small-Cell Lung Cancer Including Various Adenocarcinoma Subtypes.

Ann Thorac Cardiovasc Surg. 2018 Oct 03;:

Authors: Miyazawa T, Marushima H, Saji H, Kojima K, Hoshikawa M, Takagi M, Nakamura H

PMID: 30282880 [PubMed - as supplied by publisher]

Alveolar architectures preserved in cancer tissues may be potential pitfalls for diagnosis and histological subtyping of lung cancer: Three case reports.

Fetched: October 5th, 2018, 5:00am GMT

Alveolar architectures preserved in cancer tissues may be potential pitfalls for diagnosis and histological subtyping of lung cancer: Three case reports.

Medicine (Baltimore). 2018 Sep;97(39):e12613

Authors: Fan X, Zhang X, Wang E, Fan C

PMID: 30278581 [PubMed - in process]

The Squamous Cells of Adenosquamous Carcinoma (ASCC) of the Prostate Might Represent a Terminally Differentiated Quiescent Component: Immunohistochemical Evidence From a Case of ASCC With Pleomorphic Giant Tumor Cells.

Fetched: September 21st, 2018, 5:00am GMT

Appl Immunohistochem Mol Morphol. 2017 09;25(8):e71-e73

Authors: Acosta AM, Kajdacsy-Balla A, Groth JV

PMID: 27753662 [PubMed - indexed for MEDLINE]

Hemorrhage of MRI and Immunohistochemical Panels Distinguish Secretory Carcinoma From Acinic Cell Carcinoma.

Fetched: September 8th, 2018, 5:00am GMT

Hemorrhage of MRI and Immunohistochemical Panels Distinguish Secretory Carcinoma From Acinic Cell Carcinoma.

Laryngoscope Investig Otolaryngol. 2018 Aug;3(4):268-274

Authors: Kuwabara H, Yamamoto K, Terada T, Kawata R, Nagao T, Hirose Y

Abstract
Objectives: Secretory carcinoma (SC, mammary analogue secretory carcinoma) is a salivary gland tumor with ETV6-NTRK3 gene fusion, and its differential diagnosis includes acinic cell carcinoma (ACC). As hemorrhage is often seen in SC, we hypothesized that magnetic resonance imaging (MRI) and immunohistochemical analyses could distinguish SC from ACC.
Study Design: Retrospective study.
Methods: We used ETV6-NTRK3 gene fusion analyses to reclassify 19 parotid gland tumors that had previously been diagnosed as SC or ACC, and then investigated hemorrhage in both hematoxylin-eosin (H&E)-stained sections and MRIs, and immunohistochemical expression of S-100, mammaglobin, DOG1, and α-amylase.
Results: The 19 tumors were genetically reclassified into 11 (58%) SC and 8 (42%) ACC. Combined S-100 and mammaglobin were specific for SC; whereas DOG1 was specific for ACC, and α-amylase was expressed only in 4 ACC cases (50%). H&E staining showed hemorrhage with hemosiderin deposition in all SC cases, and T2-weighted MRI showed hypointense areas in all investigated SC cases, but not in ACC.
Conclusion: Hemorrhage with hemosiderin deposition is frequently present in SC, and hemorrhage findings in MRI and an immunohistochemical panels for S-100, mammaglobin and DOG1 can distinguish SC from ACC.
Level of Evidence: 3b.

PMID: 30186957 [PubMed]

[Pediatric salivary gland tumors and tumor-like lesions].

Fetched: August 31st, 2018, 5:00am GMT

[Pediatric salivary gland tumors and tumor-like lesions].

Pathologe. 2017 Jul;38(4):294-302

Authors: Agaimy A, Iro H, Zenk J

PMID: 28597093 [PubMed - indexed for MEDLINE]

High grade adenocarcinoma in the ectopic prostate accompanied by a low grade adenocarcinoma in the orthotopic prostate: an unusual diagnostic pitfall.

Fetched: August 26th, 2018, 5:00am GMT

High grade adenocarcinoma in the ectopic prostate accompanied by a low grade adenocarcinoma in the orthotopic prostate: an unusual diagnostic pitfall.

Pathology. 2017 Oct;49(6):665-668

Authors: Tolkach Y, Ellinger J, Müller S, Kristiansen G

PMID: 28830691 [PubMed - indexed for MEDLINE]

Pancreatic acinar cell carcinoma-induced panniculitis.

Fetched: August 23rd, 2018, 5:00am GMT

Pancreatic acinar cell carcinoma-induced panniculitis.

JAAD Case Rep. 2018 Aug;4(7):719-721

Authors: Singh S, Gorouhi F, Konia T, Burrall B

PMID: 30128347 [PubMed]

Prognostic value of epidermal growth factor receptor mutations and histologic subtypes with lung adenocarcinoma.

Fetched: August 19th, 2018, 5:00am GMT

Prognostic value of epidermal growth factor receptor mutations and histologic subtypes with lung adenocarcinoma.

Med Oncol. 2018 Jan 31;35(3):22

Authors: Motono N, Funasaki A, Sekimura A, Usuda K, Uramoto H

PMID: 29387978 [PubMed - indexed for MEDLINE]

[Clinicopatholigic features of renal cell carcinoma associated with chromosome X inversion harboring gene fusions involving TFE3].

Fetched: August 17th, 2018, 5:00am GMT

[Clinicopatholigic features of renal cell carcinoma associated with chromosome X inversion harboring gene fusions involving TFE3].

Zhonghua Bing Li Xue Za Zhi. 2018 Aug 08;47(8):574-579

Authors: Zhao YN, Wang XT, Xia QY, Wang GP, Sun SY, Zhao LF, Zhou XJ, Rao Q

PMID: 30107660 [PubMed - in process]

Pancreatic Acinar Cell Carcinoma with Multiple Liver Metastases Effectively Treated by S-1 Chemotherapy.

Fetched: August 15th, 2018, 5:00am GMT

Pancreatic Acinar Cell Carcinoma with Multiple Liver Metastases Effectively Treated by S-1 Chemotherapy.

Intern Med. 2018 Aug 10;:

Authors: Yoshida N, Kanno A, Masamune A, Nabeshima T, Hongo S, Miura S, Takikawa T, Hamada S, Kikuta K, Kume K, Ueno M, Shimosegawa T

PMID: 30101903 [PubMed - as supplied by publisher]

Pancreatic Mass in a Patient With an Increased Serum Level of IgG4.

Fetched: August 10th, 2018, 5:00am GMT

Pancreatic Mass in a Patient With an Increased Serum Level of IgG4.

Gastroenterology. 2018 08;155(2):269-270

Authors: Matsumori T, Shiokawa M, Kodama Y

PMID: 29410043 [PubMed - indexed for MEDLINE]

[Clinicopathologic and molecular genetic analysis of secretory carcinoma of salivary gland].

Fetched: August 8th, 2018, 5:00am GMT

[Clinicopathologic and molecular genetic analysis of secretory carcinoma of salivary gland].

Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 Aug 09;53(8):533-538

Authors: Zhao M, Zhao DH, Cheng G, Yan YJ, Wang Z, He XL

PMID: 30078266 [PubMed - in process]

Surgical resection of hepatic and rectal metastases of pancreatic acinar cell carcinoma (PACC): a case report.

Fetched: August 6th, 2018, 5:00am GMT

Surgical resection of hepatic and rectal metastases of pancreatic acinar cell carcinoma (PACC): a case report.

World J Surg Oncol. 2018 Aug 03;16(1):158

Authors: Ohara Y, Oda T, Enomoto T, Hisakura K, Akashi Y, Ogawa K, Owada Y, Domoto Y, Miyazaki Y, Shimomura O, Kurata M, Ohkohchi N

PMID: 30075727 [PubMed - in process]

Matt's Mile - Canton Repository

Posted: October 27th, 2018, 10:11pm GMT

Canton Repository

Matt's Mile
Canton Repository
The type of cancer is diagnosed in only about 1,200 people in the U.S. each year, according to the Adenoid Cystic Carcinoma Organization International. “We're a family and Matt is part of us,” said Jeanne McNeal, the principal at Oakwood, who said ...

Matt's Mile to be held Friday - Canton Repository

Posted: October 23rd, 2018, 6:57pm GMT

Matt's Mile to be held Friday
Canton Repository
Proceeds will help Gagnon, a 1996 GlenOak graduate and former Lake Local teacher and swim coach, pay for his mounting medical bills as he battles adenoid cystic carcinoma. Gagnon recently completed proton radiation treatments at University Hospitals in ...

Physician experts highlight research ahead of Otolaryngology's Annual Meeting - EurekAlert (press release)

Posted: October 4th, 2018, 6:42pm GMT

Physician experts highlight research ahead of Otolaryngology's Annual Meeting
EurekAlert (press release)
ALEXANDRIA, VA--The latest research on ear health, head and neck cancer, sleep-disordered breathing, rhinology and allergy, facial plastics, laryngology and swallowing disorders, endocrine surgery, and other topics related to otolaryngology-head and ...

Physician experts highlight research ahead of Otolaryngology's Annual Meeting - EurekAlert (press release)

Posted: October 4th, 2018, 6:42pm GMT

In zebrafish, a way to find new cancer therapies, targeting tumor modulators - Science Daily

Posted: September 23rd, 2018, 11:41am GMT

In zebrafish, a way to find new cancer therapies, targeting tumor modulators
Science Daily
Kaufman had founded the Adenoid Cystic Carcinoma Research Foundation with his wife, Marnie, in 2005, after she felt a lump under her jawline and was diagnosed with the rare, often deadly malignancy. (ACC usually starts in the salivary glands, but can ...

Latest Industry: Paul McCartney, YouTube, Viagogo, Caffeine, BTS, BMGPM, RCA, James Grant Group, More… - Digital Music News

Posted: September 6th, 2018, 9:54pm GMT

Digital Music News

Latest Industry: Paul McCartney, YouTube, Viagogo, Caffeine, BTS, BMGPM, RCA, James Grant Group, More…
Digital Music News
His family revealed last year Camillo battled Adenoid Cystic Carcinoma. Camilo worked with multiple major artists in the 70s, including Gladys Knight and the Pips, Eric Carmen, Dionne Warwick, Stevie Wonder, Grand Funk Railroad, Peaches and Herbs, and ...

This RSS feed URL is deprecated

Posted: August 30th, 2018, 5:00am GMT

This RSS feed URL is deprecated, please update. New URLs can be found in the footers at [https:]

Rare Subtypes of Epithelial Mesothelioma - Mesothelioma.net Blog (blog)

Posted: August 9th, 2018, 6:43pm GMT

Rare Subtypes of Epithelial Mesothelioma
Mesothelioma.net Blog (blog)
This can easily be misdiagnosed as adenoid cystic carcinoma and adenocarcinoma. Signet ring. The rare signet ring form of epithelial mesothelioma cells are characterized by the presence of a large vacuole, a space or cavity within the cell. This makes ...

New York Man Shares Journey After Being Diagnosed with Aggressive Cancer He Thought Was Jaw Pain - PEOPLE.com

Posted: August 3rd, 2018, 3:29pm GMT

PEOPLE.com

New York Man Shares Journey After Being Diagnosed with Aggressive Cancer He Thought Was Jaw Pain
PEOPLE.com
In a few days time, Powell learned he was diagnosed with Stage IV Adenoid Cystic Carcinoma, an aggressive cancer that begins in glandular tissues, most commonly those found in the oral cavity. While tumors may not cause pain in their early stages, ...

Permalink for 'Premalignant and Malignant Mucosal lesions: Clinical and Pathological Findings Part II. Premalignant and malignant mucosal lesions.'

Premalignant and Malignant Mucosal lesions: Clinical and Pathological Findings Part II. Premalignant and malignant mucosal lesions.

Fetched: November 19th, 2018, 5:00am GMT

Premalignant and Malignant Mucosal lesions: Clinical and Pathological Findings Part II. Premalignant and malignant mucosal lesions.

J Am Acad Dermatol. 2018 Nov 14;:

Authors: Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA

Abstract
Part 2 of this 2-part continuing medical education series discusses the clinical and histopathologic features of common premalignant and malignant lesions of the oral cavity. It is imperative for dermatologists to be able to recognize suspicious lesions, determine biopsy need, counsel, and refer patients presenting with premalignant or malignant conditions appropriately. Given the higher rates of mortality and morbidity of oral mucosal malignancies due to late diagnosis, appropriate treatment with multidisciplinary care in a timely manner is essential to these neoplasms.

PMID: 30447325 [PubMed - as supplied by publisher]

Prognostic factors and survival in adenoid cystic carcinoma of the sinonasal cavity.

Fetched: November 19th, 2018, 5:00am GMT

Prognostic factors and survival in adenoid cystic carcinoma of the sinonasal cavity.

Head Neck. 2018 Nov 17;:

Authors: Mays AC, Hanna EY, Ferrarotto R, Phan J, Bell D, Silver N, Mulcahy CF, Roberts D, Abdelmeguid ASA, Fuller CD, Frank SJ, Raza SM, Kupferman ME, DeMonte F, Su SY

Abstract
BACKGROUND: Optimal treatment and prognostic factors affecting long-term survival in patients with sinonasal adenoid cystic carcinoma (ACC) have yet to be clearly defined.
METHODS: We conducted a retrospective review of patients treated with curative intent from 1980-2015 at MD Anderson Cancer Center.
RESULTS: One hundred sixty patients met inclusion criteria, including 8 who were treated with radiotherapy alone. Median follow-up time was 55 months. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 67.0% and 49.0%, respectively. The 10-year OS and DFS rates were 44.8% and 25.4%, respectively. Factors that portended for poor survival on multivariate analysis were recurrent disease, any solid type histology, epicenter in the sinus cavity, the presence of facial symptoms, or the original disease not treated with surgery. There was no association between surgical margin status or nodal status and survival.
CONCLUSION: In this large cohort of patients with sinonasal ACC with extended follow-up, long-term survival is better than reported in prior literature. Future research should target patients with adverse risk factors.

PMID: 30447126 [PubMed - as supplied by publisher]

Permalink for 'Molecular methods for detection of prognostic and predictive markers in diagnosis of adenoid cystic carcinoma of the salivary gland origin.'

Molecular methods for detection of prognostic and predictive markers in diagnosis of adenoid cystic carcinoma of the salivary gland origin.

Fetched: November 19th, 2018, 5:00am GMT

Molecular methods for detection of prognostic and predictive markers in diagnosis of adenoid cystic carcinoma of the salivary gland origin.

Cesk Patol. 2018;54(3):132-136

Authors: Šteiner P, Pavelka J, Vaneček T, Miesbauerová M, Skálová A

Abstract
Adenoid cystic carcinoma of salivary gland origin (AdCC) is second most common salivary carcinoma characterized by frequent recurrences, perineural invasion and high long-term mortality rate. The surgical resection of the tumor in combination with adjuvant radiotherapy is the only method of choice. AdCC has been studied, altogether with immunohistochemistry, by numerous molecular-genetic techniques. Some of them, e.g. reverse-transcription PCR or fluorescent in situ hybridization contributed to the identification of translocation t(6;9)(q22-23;p23-24), which results in fusion of two transcription factors MYB-NFIB. For AdCC is this fusion unique among salivary gland carcinomas and serves as a diagnostical tool in differential diagnosis of histopathologically difficult cases. More complex methods, such as next-generation sequencing helped to detect other molecular level changes; and hence improved understanding of a development, behavior and pathogenesis of this possibly fatal malignancy. This review summarizes basic knowledge of AdCC on the genome, transcriptome and epigenetic level, which were achieved using molecular-genetic and immunohistochemical methods. Keywords: adenoid cystic carcinoma - salivary carcinoma - MYB-NFIB - FISH - aCGH - NGS.

PMID: 30445817 [PubMed - in process]

[Management of a tracheal adenoid cystic medico-surgical carcinoma].

Fetched: November 19th, 2018, 5:00am GMT

[Management of a tracheal adenoid cystic medico-surgical carcinoma].

Rev Mal Respir. 2018 Nov 12;:

Authors: Thiam K, Carmassi M, Guinde J, Laroumagne S, Thomas P, Astoul P, Dutau H

Abstract
Adenoid cystic carcinoma or cylindroma is a rare tumor of the trachea which arises from mucous secreting cells. Its evolution and growth are slow but it is often fatal in the absence of radical treatment. The latter relies on a surgical sleeve resection of the pathological area, with a tracheo-tracheal anastomosis. Therapeutic bronchoscopy plays a crucial role in the clinical improvement of patients before surgery which will be performed under better conditions. For inoperable patients, radiotherapy has proved its efficacy, unlike conventional chemotherapy. The finding of biomarkers expressed by tumor cells could lead to target therapies. This case report illustrates the efficient combination of therapeutic bronchoscopy and surgery for the treatment of adenoid cystic carcinoma affecting central airways.

PMID: 30442482 [PubMed - as supplied by publisher]

Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.

Fetched: November 17th, 2018, 5:00am GMT

Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.

Front Oncol. 2018;8:492

Authors: Zhang M, Wu JS, Yang X, Pang X, Li L, Wang SS, Wu JB, Tang YJ, Liang XH, Zheng M, Tang YL

Abstract
Objective: Cathepsin D (CTSD) is a pivotal orchestrator in the occurrence and development of tumors. Recently, CTSD was detected in salivary adenoid cystic carcinoma (SACC). However, its functional role in perineural invasion (PNI) of SACC remained elusive. We conducted the present study to detect the expression of CTSD in SACC, analyze the correlation between CTSD expression and prognosis of SACC patients and elucidate the role of CTSD in occurrence of PNI in SACC to lay the foundation for further studies. Methods: Immunohistochemical analysis was conducted to assess CTSD and Ki67 expression in 158 SACC samples and 20 normal salivary gland samples adjacent to carcinoma. Meanwhile, the correlation between CTSD and PNI of SACC specimens was analyzed using Wilcoxon test. QRT-PCR, immunofluorescence and western blot analysis were used to examine the levels of CTSD mRNA and protein in SACC-LM cell line. SiRNA-mediated CTSD silence was performed. Scratch wound healing assay, transwell invasion assay and DRG co-culture assay of PNI was used to detect the ability of migration, invasion and PNI. FITC-phalloidin was used to detect cytoskeletal organization. Results: Our data demonstrated that the positive expression of CTSD was observed in 74.1% (117/158) of SACC cases, and the expression of CTSD was significantly correlated with the PNI (p < 0.05). The ability of migration, invasion, and PNI could be inhibited significantly by siRNA-mediated CTSD silence (p < 0.01). Furthermore, siRNA-mediated CTSD silence inhibited cytoskeletal organization and pseudo foot formation in SACC-LM cells. Conclusion: Our results suggested that an association between PNI and expression of CTSD existed. CTSD may promote PNI of SACC accompanied by cytoskeletal organization and pseudo foot formation.

PMID: 30430081 [PubMed]

Permalink for 'Proliferative Activity of Myoepithelial Cells in Normal Salivary Glands and Adenoid Cystic Carcinomas Based on Double Immunohistochemical Labeling'

Proliferative Activity of Myoepithelial Cells in Normal Salivary Glands and Adenoid Cystic Carcinomas Based on Double Immunohistochemical Labeling

Fetched: November 17th, 2018, 5:00am GMT

Proliferative Activity of Myoepithelial Cells in Normal Salivary Glands and Adenoid Cystic Carcinomas Based on Double Immunohistochemical Labeling

Asian Pac J Cancer Prev. 2018 Jul 27;19(7):1965-1970

Authors: Alali F, Kochaji N

Abstract
Objective: To investigate the proliferative activity of myoepithelial cells (MEC) in normal salivary glands (NSG) and adenoid cystic carcinomas (ACC)) Study design. Twenty -three salivary gland specimens (13 ACC, 10 NSG) were studied using double immunohistochemical labeling for α smooth muscle actin (a-SMA) and proliferative cell nuclear antigen (PCNA)). Results: There was a significant difference in PCNA reactivity in normal samples between myoepithelial cells of the parotid glands and of the submandibular glands, rates being higher in the latter. Neoplastic myoepithelial cells exhibited higher expression than neoplastic epithelial cells. In addition, myoepithelial cells of the cribriform type of ACC showed PCNA reactivity lower than those of the tubular type, whereas there was no statistically significant difference in epithelial cell rates. We could not identify myoepithelial cells in solid pattern due to α-SMA negativity; although high PCNA reactivity was evident. Conclusion: These data suggest that the myoepithelial cell has a key role in ACC oncogenesis, more so than its epithelial cell counterparts. Moreover, the data provide a histopathological interpretation for aggressive clinical features of submandibular ACC, as the myoepithelial cells were less differentiated as compared to those of parotid glands.

PMID: 30051681 [PubMed - indexed for MEDLINE]

PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms.

Fetched: November 16th, 2018, 5:00am GMT

PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms.

J Pathol Transl Med. 2018 Nov 14;:

Authors: Lee JH, Kang HJ, Yoo CW, Park WS, Ryu JS, Jung YS, Choi SW, Park JY, Han N

Abstract
Background: Recent findings in molecular pathology suggest that genetic translocation and/or overexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. We investigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues.
Materials and Methods: A total of 113 cases of surgically resected salivary gland neoplasms at the National Cancer Center from January 2007 to March 2017 were identified. Immunohistochemical staining of PLAG1, SOX10, and Myb in tissue samples was performed using tissue microarrays.
Results: Among the 113 cases, 82 (72.6%) were benign and 31 (27.4%) were malignant. PLAG1 showed nuclear staining and normal parotid gland was not stained. Among 48 cases of pleomorphic adenoma, 29 (60.4%) were positive for PLAG1. All other benign and malignant salivary gland neoplasms were PLAG1-negative. SOX10 showed nuclear staining. In normal salivary gland tissues SOX10 was expressed in cells of acinus and intercalated ducts. In benign tumors, SOX10 expression was observed in all pleomorphic adenoma (48/48), and basal cell adenoma (3/3), but not in other benign tumors. SOX10 positivity was observed in 9 of 31 (29.0%) malignant tumors. Myb showed nuclear staining but was not detected in normal parotid glands. Four of 31 (12.9%) malignant tumors showed Myb positivity: 3 adenoid cystic carcinomas (AdCC) and 1 myoepithelial carcinoma with focal AdCC-like histology.
Conclusion: PLAG1 expression is specific to pleomorphic adenoma. SOX10 expression is helpful to rule out excretory duct origin tumor, but its diagnostic value is relatively low. Myb is useful for diagnosing AdCC when histology is unclear in the surgical specimen.

PMID: 30424592 [PubMed - as supplied by publisher]

Microfluidic Analyzer Enabling Quantitative Measurements of Specific Intracellular Proteins at the Single-Cell Level.

Fetched: November 16th, 2018, 5:00am GMT

Microfluidic Analyzer Enabling Quantitative Measurements of Specific Intracellular Proteins at the Single-Cell Level.

Micromachines (Basel). 2018 Nov 12;9(11):

Authors: Liu L, Fan B, Wang D, Li X, Song Y, Zhang T, Chen D, Wang Y, Wang J, Chen J

Abstract
This paper presents a microfluidic instrument capable of quantifying single-cell specific intracellular proteins, which are composed of three functioning modules and two software platforms. Under the control of a LabVIEW platform, a pressure module flushed cells stained with fluorescent antibodies through a microfluidic module with fluorescent intensities quantified by a fluorescent module and translated into the numbers of specific intracellular proteins at the single-cell level using a MATLAB platform. Detection ranges and resolutions of the analyzer were characterized as 896.78⁻6.78 × 10⁵ and 334.60 nM for Alexa 488, 314.60⁻2.11 × 10⁵ and 153.98 nM for FITC, and 77.03⁻5.24 × 10⁴ and 37.17 nM for FITC-labelled anti-beta-actin antibodies. As a demonstration, the numbers of single-cell beta-actins of two paired oral tumor cell types and two oral patient samples were quantified as: 1.12 ± 0.77 × 10⁶/cell (salivary adenoid cystic carcinoma parental cell line (SACC-83), ncell = 13,689) vs. 0.90 ± 0.58 × 10⁵/cell (salivary adenoid cystic carcinoma lung metastasis cell line (SACC-LM), ncell = 15,341); 0.89 ± 0.69 × 10⁶/cell (oral carcinoma cell line (CAL 27), ncell = 7357) vs. 0.93 ± 0.69 × 10⁶/cell (oral carcinoma lymphatic metastasis cell line (CAL 27-LN2), ncell = 6276); and 0.86 ± 0.52 × 10⁶/cell (patient I) vs. 0.85 ± 0.58 × 10⁶/cell (patient II). These results (1) validated the developed analyzer with a throughput of 10 cells/s and a processing capability of ~10,000 cells for each cell type, and (2) revealed that as an internal control in cell analysis, the expressions of beta-actins remained stable in oral tumors with different malignant levels.

PMID: 30424565 [PubMed]

Primary Lung Tumors in Children: Radiologic-Pathologic Correlation From the Radiologic Pathology Archives.

Fetched: November 15th, 2018, 5:00am GMT

Primary Lung Tumors in Children: Radiologic-Pathologic Correlation From the Radiologic Pathology Archives.

Radiographics. 2018 Nov-Dec;38(7):2151-2172

Authors: Lichtenberger JP, Biko DM, Carter BW, Pavio MA, Huppmann AR, Chung EM

Abstract
Primary lung tumors in children are rare, with a narrow range of diagnostic considerations. However, the overlapping imaging appearances of these tumors necessitate attention to key discriminating imaging and pathologic features. In the neonate and infant, the important considerations include pleuropulmonary blastoma (PPB), infantile fibrosarcoma, and fetal lung interstitial tumor. Among these tumors, imaging findings such as air-filled cysts in type 1 PPB and homogeneously low attenuation of fetal lung interstitial tumors are relatively specific. Key pathologic and genetic discriminators among this group of tumors include the DICER1 germline mutation found in PPB and the t(12,15)(p13;q25) translocation and ETV6-NTRK3 fusion gene seen in infantile fibrosarcoma. Primary lung tumors in older children include inflammatory myofibroblastic tumors (IMTs), carcinoid salivary gland-type tumors of the lung, recurrent respiratory papillomatosis, and other rare entities. IMT, a spindle-cell proliferation with inflammatory elements, is the most common lung tumor in children. Anaplastic lymphoma kinase, a receptor-type protein tyrosine kinase, is present in 50% of these tumors, and this finding may support an imaging diagnosis of IMT. Carcinoid tumors account for a substantial portion of childhood lung tumors, and their characteristic avid enhancement on images corresponds to the compressed fibrovascular stroma histologically. Furthermore, novel imaging agents used with somatostatin receptor analogs have an emerging role in the evaluation of carcinoid tumors. Although less common than mucoepidermoid carcinoma, adenoid cystic carcinoma tends to recur given the perineural spread seen histologically. Integrating radiologic and pathologic knowledge is critical to accurate diagnosis, treatment planning, and surveillance of primary lung tumors in children.

PMID: 30422774 [PubMed - in process]

Programmed death ligand 1 and CD8+ immune cell infiltrates in resected primary tracheal malignant neoplasms.

Fetched: November 14th, 2018, 5:00am GMT

Programmed death ligand 1 and CD8+ immune cell infiltrates in resected primary tracheal malignant neoplasms.

Eur J Cardiothorac Surg. 2018 Nov 12;:

Authors: Tapias LF, Shih A, Mino-Kenudson M, Muniappan A, Gaissert HA, Lanuti M, Mathisen DJ, Ott HC

Abstract
OBJECTIVES: Many patients with primary malignant tracheal neoplasms are not surgical candidates nor do they experience residual or recurrent disease after surgery and may benefit from alternative therapies. This study explores the expression of programmed death ligand 1 (PD-L1) in patients with primary tracheal malignancy as a biomarker for candidacy for treatment with immune checkpoint inhibitors.
METHODS: We conducted a retrospective review of the medical records of 23 patients with resected primary tracheal malignant tumours from 2010 to 2016. Paraffin-embedded blocks of tumour tissue were evaluated immunohistochemically to determine the expression of PD-L1 and infiltration by CD8+ immune cells.
RESULTS: We identified 14 (61%) adenoid cystic carcinomas, 4 (17%) squamous cell carcinomas (SCC), 4 (17%) mucoepidermoid carcinomas and 1 adenosquamous carcinoma. PD-L1 expression was observed in 3 (75%) cases of SCC and 1 (100%) case of adenosquamous carcinoma, but it was absent in cases of adenoid cystic carcinomas and mucoepidermoid carcinomas. PD-L1 expression was significantly higher in tumours with a SCC component than in salivary-type tumours (P = 0.001). The presence of CD8+ immune cells in the tumour or peritumoural stroma was significantly higher in cases of tracheal tumours with a SCC component than in salivary-type tumours.
CONCLUSIONS: Salivary-type primary malignant tracheal tumours do not significantly express PD-L1. In contrast, most primary tracheal tumours with a SCC component show membranous expression of PD-L1 and larger numbers of infiltrating CD8+ immune cells. PD-L1 expression may serve as a biomarker in patients with primary tracheal squamous cell malignant neoplasms when the patients are being considered for alternative treatments and inclusion in clinical trials.
IRB Approval: Protocol No. 2017P000415 (22 March 2017).

PMID: 30418532 [PubMed - as supplied by publisher]

[Current opinions on the diagnosis and intervention of adenoid cystic carcinoma in external auditory canal].

Fetched: November 9th, 2018, 5:00am GMT

[Current opinions on the diagnosis and intervention of adenoid cystic carcinoma in external auditory canal].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Oct;32(20):1527-1530

Authors: Dai CF, Li XY

PMID: 30400701 [PubMed]

[Clinical diagnosis and treatment of adenoid cystic carcinoma of the external auditory canal].

Fetched: November 9th, 2018, 5:00am GMT

[Clinical diagnosis and treatment of adenoid cystic carcinoma of the external auditory canal].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Nov;32(21):1660-1664

Authors: Gao Y, Yang H, Chen F, Lv D, Chen Y, Chen YZ

Abstract
Objective:To discuss the clinical diagnosis, therapies and prognosis of adenoid cystic carcinoma of external auditory canal.Method:Eleven patients with adenoid cystic carcinoma of external auditory canal, who had been admitted to West China hospital, Sichuan university from April 2009 to October 2015 were recruited and a retrospective analysis was performed.Result:All the 11 patients were treated with surgery except one elderly with T1 stage who was only treated with radiotherapy(RT),1 of the 10 patients treated with surgery were added on radiotherapy after surgery. Following up for 12-104 months,the patient who was treated with RT alone has survived with carcinoma for 51 months by now,among the remainder stage T1 patients,one was reoperated for local recurrence 95 months after surgery, and therefore survived without recurrence.The other 2 patients all survived with free-disease;in the stage T2 patients,one was lost to follow-up after identified local recurrence with pulmonary masses 12 months after surgery, another one committed suicide because of family problems 56 months after operation,and the other one survived without recurrence for 57 months after surgery; the stage T3 patient survived without recurrence for 26 months at present;in the T4 patients, one died after gamma knife therapy for local recurrent disease with brain metastasis 22 months after surgery, another one died from pulmonary metastasis 17 months after surgery,and the other one survived without recurrence for 56 months.Conclusion:Adenoid cystic carcinoma of external auditory canal is a rare disease with high misdiagnosis rate and progresses slowly.Surgery is the preferred therapy.The prognosis is closely related to disease clinical stage at presentation type of pathology and surgical approaches. Adenoid cystic carcinoma of external auditory canal is characteristically susceptible to local recurrence and distant metastasis,inaddition to routine re-exam of ear,the patients should be reviewed carefully to exclude of pulmonary,brain and kidney metastasis during follow-up.

PMID: 30400692 [PubMed]

Expression of EpCAM in adenoid cystic carcinoma.

Fetched: November 7th, 2018, 5:00am GMT

Expression of EpCAM in adenoid cystic carcinoma.

Pathology. 2018 Oct 30;:

Authors: Lee SJ, Chung KY, Kwon JE, Yoon SO, Kim SK

Abstract
The mutational landscape of adenoid cystic carcinoma (ACC) is currently being revealed, but further studies are needed to identify biomarkers as therapeutic targets or prognostic factors of ACC. In this study, we investigated the expression of epithelial cell adhesion molecule (EpCAM) in ACCs. We retrospectively collected 83 cases of surgically resected ACCs. Using tissue microarray, we conducted immunohistochemical staining using the anti-EpCAM antibody. EpCAM expression was analysed by intensity score and the total immunostaining score. The positivity was 97.6% (81/83 cases), regardless of the intensity score. A higher histological grade (p = 0.006) and specific tumour location (non-salivary gland origin, p = 0.02) showed a correlation with higher EpCAM intensity. Higher EpCAM expression by total immunostaining score was associated with histological grade (p = 0.004), distant metastasis (p = 0.004) and poorer prognosis (overall survival p = 0.015 and progression-free survival p = 0.033). We suggest EpCAM as a candidate prognostic marker and a putative therapeutic target in ACC. Also, ACCs arising from salivary gland and non-salivary gland sites, respectively, might display different pathophysiologies in which EpCAM could play a role.

PMID: 30389218 [PubMed - as supplied by publisher]

Use of medial upper arm free flap in oral cavity reconstruction: a preliminary study.

Fetched: November 7th, 2018, 5:00am GMT

Use of medial upper arm free flap in oral cavity reconstruction: a preliminary study.

Int J Oral Maxillofac Surg. 2018 May;47(5):595-602

Authors: Saenthaveesuk P, Zhang SE, Zheng GS, Liang YJ, Su YX, Liao GQ

Abstract
The medial upper arm has previously been proposed as a potential free flap donor site, but the clinical application of such flaps in head and neck reconstruction has not been popular. The preliminary results of the clinical application of medial upper arm free flaps in oral cavity reconstruction are reported here. Five patients with oral cancer underwent surgical resection and neck dissection, with simultaneous reconstruction using a medial upper arm free flap. Functional outcomes were investigated using the University of Washington Quality of Life Questionnaire. Sensory-motor functions of the upper arm donor site were recorded before and after surgery. Four flaps were successfully transferred. One flap was abandoned during surgery because of a lack of perforators, and a forearm flap was used instead. All patients survived without loco-regional recurrence or distant metastasis. Functional outcomes, especially swallowing and speech, were satisfactory. The donor site scar was well hidden, with no functional impairment. This initial experience shows that the medial upper arm free flap represents an alternative perforator flap for oral cavity microsurgical reconstruction. The well-hidden scar and better texture match compared with other flaps make it suitable for oral cavity reconstruction.

PMID: 29366529 [PubMed - indexed for MEDLINE]

Advanced adenoid cystic carcinoma (ACC) is featured by SWI/SNF chromatin remodeling complex aberrations.

Fetched: November 3rd, 2018, 5:00am GMT

Advanced adenoid cystic carcinoma (ACC) is featured by SWI/SNF chromatin remodeling complex aberrations.

J Cancer Res Clin Oncol. 2018 Oct 31;:

Authors: Jagielska B, Sarnowska E, Rusetska N, Jancewicz I, Durzynska M, Kubala S, Chmielik E, Paul P, Rutkowski T, Sarnowski TJ, Siedlecki JA

Abstract
PURPOSE: Adenoid cystic carcinoma (ACC) is a rare neurotropic cancer with slow progression occurring in salivary glands and less frequently in other body parts. ACC is featured by hyperchromatic nuclei and various mutations in genes encoding chromatin-related machineries. The ACC treatment is mainly limited to the radical surgery and radiotherapy while the chemotherapy remains ineffective. As the knowledge about molecular basis of ACC development is limited, we investigated here the molecular features of this disease.
PATIENTS AND METHODS: This study included 50 patients with ACC. Transcript profiling of available ACC samples vs normal salivary gland tissue, quantitative real-time PCR (qRT-PCR) transcript level measurements and the immunohistochemistry (IHC) for SWI/SNF chromatin remodeling complex (CRC) subunits and androgen receptor on surgery-derived paraffin-embedded samples were performed.
RESULTS: Transcriptomic study followed by Gene Ontology classification indicated alteration of chromatin-related processes, including downregulated transcript levels of main SWI/SNF CRC subunits and elevated expression of BRM ATPase-coding SMARCA2 gene in ACC. Subsequent IHC indicated broad accumulation of BRM ATPase and several SWI/SNF subunits, suggesting affected control of their protein level in ACC. The IHC revealed ectopic, heterogeneous expression of androgen receptor (AR) in some ACC cells.
CONCLUSIONS: Our study indicated that ACC features aberrant expression of genes controlling chromatin status and structure. We found that the balance between SWI/SNF classes is moved towards the BRM ATPase-containing complex in ACC. As BRM is known to be involved in chemoresistance in cancer cells, this observation may be the likely explanation for ACC chemoresistance.

PMID: 30382367 [PubMed - as supplied by publisher]

Spinal Metastases from Adenoid Cystic Carcinoma of the Parotid Gland.

Fetched: November 3rd, 2018, 5:00am GMT

Spinal Metastases from Adenoid Cystic Carcinoma of the Parotid Gland.

Chin Med J (Engl). 2018 Nov 05;131(21):2616-2617

Authors: Liu SZ, Zhou X, Song A, Huo Z, Zhang J, Wang YP, Liu Y

Abstract

PMID: 30381599 [PubMed - in process]

NKX2.2 immunohistochemistry in the distinction of ewing sarcoma from cytomorphologic mimics: Diagnostic utility and pitfalls.

Fetched: November 1st, 2018, 5:00am GMT

NKX2.2 immunohistochemistry in the distinction of ewing sarcoma from cytomorphologic mimics: Diagnostic utility and pitfalls.

Cancer Cytopathol. 2018 Oct 30;:

Authors: Russell-Goldman E, Hornick JL, Qian X, Jo VY

Abstract
BACKGROUND: Ewing sarcoma (ES) is a round cell sarcoma that can be challenging to diagnose on cytologic material given its significant overlap with numerous mesenchymal, epithelial, and lymphoid cytomorphologic mimics. The objective of this study was to assess the utility of a novel marker, NKX2.2, in the diagnosis of ES in cytologic material and its ability to distinguish ES from its mimics.
METHODS: NKX2.2 immunohistochemistry was performed on cell blocks from 107 fine-needle aspirations, and nuclear expression was scored semiquantitatively for extent and intensity. The study cohort included ES (n = 10), well differentiated neuroendocrine tumor (n = 20), melanoma (n = 11), Merkel cell carcinoma (n = 10), small cell carcinoma (n = 10), alveolar rhabdomyosarcoma (n = 2), spindle cell/sclerosing rhabdomyosarcoma (n = 2), synovial sarcoma (n = 12), solitary fibrous tumor (n = 2), chronic lymphocytic leukemia (n = 10), lymphoblastic lymphoma (n = 11), adenoid cystic carcinoma (n = 6), and CIC-rearranged sarcoma (n = 1).
RESULTS: NKX2.2 had high sensitivity (100%) and moderate specificity (85%) for the diagnosis of ES in cytologic material. NKX2.2 expression also was present in a subset of mesenchymal and epithelial mimics, and staining was most commonly observed in small cell carcinoma (80%) and well differentiated neuroendocrine tumor (45%). Among mesenchymal mimics, 42% exhibited NKX2.2 expression. NKX2.2 staining was absent in melanoma, adenoid cystic carcinoma, and lymphoproliferative neoplasms.
CONCLUSIONS: NKX2.2 is a highly sensitive but only moderately specific marker for ES. Neuroendocrine neoplasms exhibit variable NKX2.2 expression and remain a significant potential diagnostic pitfall. Thus, NKX2.2 expression should be interpreted in the context of an appropriate immunohistochemical panel (and often with confirmatory molecular testing) for the accurate diagnosis of ES.

PMID: 30376220 [PubMed - as supplied by publisher]

Permalink for 'Diagnostic Accuracy of Fine Needle Aspiration Cytology in Lesions of Oral Cavity and Salivary Glands: A Clinico-Pathological Study.'

Diagnostic Accuracy of Fine Needle Aspiration Cytology in Lesions of Oral Cavity and Salivary Glands: A Clinico-Pathological Study.

Fetched: October 31st, 2018, 5:00am GMT

Diagnostic Accuracy of Fine Needle Aspiration Cytology in Lesions of Oral Cavity and Salivary Glands: A Clinico-Pathological Study.

Open Dent J. 2018;12:782-790

Authors: Shalley S, Chand N, Aggarwal A, Garg LN, Yadav V, Yadav A

Abstract
Objective: Fine Needle Aspiration Cytology (FNAC) is a rapid, reliable and safe diagnostic tool used for various lesions of the oral cavity and salivary glands. The present study was undertaken to categorize the cytomorphology of the oral cavity and salivary gland lesions on FNAC and to assess the accuracy of FNAC in arriving at a diagnosis.
Materials and Methods: A prospective study on oral cavity swellings and salivary gland aspirates was done during a 2 year period from August 2015 to July 2017 in which a total of 70 FNAC's were performed. There were 12 aspirates obtained from oral cavity swellings and 58 aspirates were obtained from salivary glands. Histopathological evaluation of 65 lesions was done and was considered as gold standard. Only the lesions undergoing histopathological confirmation were included in the study. The sensitivity, specificity, diagnostic accuracy and clinical utility index were evaluated for accuracy of FNAC.
Results: Hard palate (33.33%) was the predominantly aspirated site in the oral cavity. Parotid gland was the predominant gland aspirated (60.32%) among the involved salivary glands. Non-neoplastic lesions constituted 18.47% cases whereas neoplastic lesions were 81.53% (60.00% benign and 21.53% malignant). Pleomorphic adenoma (28.65%) was the most common benign lesion in the oral cavity involving hard palate and as salivary gland neoplasm (70.54%). Squamous cell carcinoma (60%) was the most common malignant lesion of oral cavity involving the tongue and buccal mucosa and adenoid cystic carcinoma (44.45%) was the commonest malignancy in salivary gland malignant neoplasms. The overall sensitivity, specificity and accuracy of FNAC in the present study were 89.5%, 100% and 85% respectively.
Conclusion: FNAC is a safe, cost-effective and reliable technique effective in diagnosing the spectrum of different lesions in the oral and maxillofacial region.

PMID: 30369988 [PubMed]

Emergency Tracheal Surgery for Adenoid Cystic Carcinoma: A Rare Entity.

Fetched: October 31st, 2018, 5:00am GMT

Emergency Tracheal Surgery for Adenoid Cystic Carcinoma: A Rare Entity.

J Coll Physicians Surg Pak. 2018 Nov;28(11):882-884

Authors: Majeed FA, Zafar U, Ali A, Mehmood U, Husnain MR

Abstract
Primary tumours of the trachea are rare. Adenoid cystic carcinoma (ACC) constitutes less than 1% of these tumours. They occasionally masquerade as asthma. We are presenting a case of a young female, who had been treated for 3 years as asthma. She presented in emergency with severe respiratory difficulty, stridor and decreasing saturation of 85% on room air. Two weeks back, she had a CT scan in a local hospital, but they did not notify the tracheal mass. Her clinical picture and CT scan helped us diagnose the case. She was treated in emergency with primary resection of tracheal mass and anastomosis. The tumor was diagnosed as ACC. Postoperative recovery was uneventful. Continuity of the trachea was restored and adjuvant radiotherapy was given.

PMID: 30369385 [PubMed - in process]

Abnormal activation of the Akt signaling pathway in adenoid cystic carcinoma.

Fetched: October 29th, 2018, 5:00am GMT

Abnormal activation of the Akt signaling pathway in adenoid cystic carcinoma.

Eur Arch Otorhinolaryngol. 2018 Oct 26;:

Authors: Branco KFCC, Ribeiro ALR, de Mendonça RP, de Jesus Viana Pinheiro J, da Silva Kataoka MS, Arnaud MVC, de Melo Alves Junior S

Abstract
PURPOSE: Adenoid cystic carcinoma (ACC) is an intriguing lesion because it shows a slow growth in the beginning, but a late poor prognosis due to perineural invasion, metastasis and recurrence. This study aimed to investigate whether Akt signaling would be deregulated in adenoid cystic carcinoma and its consequence in the expression of associated proteins.
METHODS: The expression of the Akt, p-Akt, NFκB, β-catenin, cyclin D1 and COX-2 was assessed by immunohistochemistry in 10 cases of ACC, 17 cases of pleomorphic adenoma (PA), and 7 cases of normal salivary gland (NSG).
RESULTS: p-Akt was overexpressed in ACC when compared to NSG. NFκB, β-catenin, and COX-2 were overexpressed in ACC and PA when compared to NSG. Most proteins were slightly higher expressed in ACC than in PA, but they never reached significance. p-Akt expression positively correlated with NFκB, β-catenin, cyclin D1 and COX-2 in ACC and PA, while this correlation trended to be negative in for these proteins (except for NFκB) in NSG using Person's correlation analysis, but without reaching significance.
CONCLUSIONS: Our results indicate an abnormal activation of Akt signaling pathway, which can be an important regulator of tumor biology in ACC. Activated Akt correlated with the expression of NFκB, β-catenin and COX-2, which can potentially influence cell survival in ACC.

PMID: 30367261 [PubMed - as supplied by publisher]

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