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Posted: August 30th, 2018, 5:00am GMT

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lobular breast carcinoma in situ child sexual abuse poems - French Tribune

Posted: August 12th, 2018, 8:16pm GMT

lobular breast carcinoma in situ child sexual abuse poems
French Tribune
lobular breast carcinoma in situ. Lobular carcinoma healing from sexual abuse poems in situ lcis is an incidental microscopic finding with characteristic cellular morphology and multifocal tissue patterns.The condition is a laboratory diagnosis and ...

Acinic Cell Carcinoma - News-Medical.net

Posted: June 20th, 2018, 11:28pm GMT

News-Medical.net

Acinic Cell Carcinoma
News-Medical.net
Acinic cell carcinoma is a rare cancer of the salivary glands that originates from the parotid gland. It is a low-grade salivary neoplasm that constitutes about 5% to 17% of cases involving salivary gland malignancies. In comparison with other salivary ...

Hydrogel microenvironments for cancer spheroid growth and drug screening - Science Advances

Posted: April 27th, 2018, 4:09pm GMT

Hydrogel microenvironments for cancer spheroid growth and drug screening
Science Advances
Biomimetic hydrogel scaffolds for MCS growth offer a broad spectrum of biophysical and biochemical cues that help to recapitulate the behavior of natural extracellular matrix, essential for regulating cancer cell behavior. This perspective highlights ...

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Permalink for 'The Squamous Cells of Adenosquamous Carcinoma (ASCC) of the Prostate Might Represent a Terminally Differentiated Quiescent Component: Immunohistochemical Evidence From a Case of ASCC With Pleomorphic Giant Tumor Cells.'

The Squamous Cells of Adenosquamous Carcinoma (ASCC) of the Prostate Might Represent a Terminally Differentiated Quiescent Component: Immunohistochemical Evidence From a Case of ASCC With Pleomorphic Giant Tumor Cells.

Fetched: September 21st, 2018, 5:00am GMT

The Squamous Cells of Adenosquamous Carcinoma (ASCC) of the Prostate Might Represent a Terminally Differentiated Quiescent Component: Immunohistochemical Evidence From a Case of ASCC With Pleomorphic Giant Tumor Cells.

Appl Immunohistochem Mol Morphol. 2017 09;25(8):e71-e73

Authors: Acosta AM, Kajdacsy-Balla A, Groth JV

PMID: 27753662 [PubMed - indexed for MEDLINE]

Permalink for 'MR imaging features of mammary analogue secretory carcinoma and acinic cell carcinoma of the salivary gland: a preliminary report.'

MR imaging features of mammary analogue secretory carcinoma and acinic cell carcinoma of the salivary gland: a preliminary report.

Fetched: September 20th, 2018, 5:00am GMT

MR imaging features of mammary analogue secretory carcinoma and acinic cell carcinoma of the salivary gland: a preliminary report.

Dentomaxillofac Radiol. 2018 Jul;47(5):20170218

Authors: Kashiwagi N, Nakatsuka SI, Murakami T, Enoki E, Yamamoto K, Nakanishi K, Chikugo T, Kurisu Y, Kimura M, Hyodo T, Tsukabe A, Kakigi T, Tomita Y, Ishii K, Narumi Y, Yagyu Y, Tomiyama N

Abstract
OBJECTIVES: To report MR imaging features of mammary analogue secretory carcinoma (MASC) and acinic cell carcinoma (AciCC) of the salivary gland based on the latest version of the World Health Organization (WHO) 2017 classification of head and neck tumours.
METHODS: MR images in 4 patients with MASC and 4 with AciCC were reviewed for margin characteristics, the presence of pathological cervical nodes, the presence of a cystic component and interface between cystic and solid component, signal intensity of the cystic components on T1 weighted images, and signal intensity of the solid component on T1 and T2 weighted images.
RESULTS: All the MASCs and AciCCs had well-defined boundaries, and 1 AciCC had pathological nodes. All 4 MASCs presented as predominantly cystic tumours with papillary projection of the solid component. All 4 AciCCs presented as solid tumours. The signal intensity of the cystic components on T1 weighted images was entirely hyperintense in 2, and partly hyperintense demonstrating fluid-fluid level in 2. In all the MASCs, the signal intensity of the solid components on T1 weighted images was intermediate. In the AciCCs, the signal intensity of the solid components on T1 weighted images was high in 2 tumours and intermediate in 2. The signal intensity of the solid components on T2 weighted images varied from low to high in both MSACs and AciCCs.
CONCLUSIONS: All 4 MASCs had a large cystic component, including areas of high signal intensity on T1 weighted images. The solid component appeared as a papillary projection into the cystic component. All 4 AciCCs presented as solid tumours, 2 of which showed high signal intensity on T1 weighted images.

PMID: 29493279 [PubMed - indexed for MEDLINE]

So-called acinic cell carcinoma of the breast arises from microgladular adenosis and is not a distinct entity.

Fetched: September 16th, 2018, 5:00am GMT

So-called acinic cell carcinoma of the breast arises from microgladular adenosis and is not a distinct entity.

Mod Pathol. 2017 10;30(10):1504

Authors: Rosen PP

PMID: 28972583 [PubMed - indexed for MEDLINE]

[Pediatric salivary gland tumors and tumor-like lesions].

Fetched: August 31st, 2018, 5:00am GMT

[Pediatric salivary gland tumors and tumor-like lesions].

Pathologe. 2017 Jul;38(4):294-302

Authors: Agaimy A, Iro H, Zenk J

Abstract
Salivary gland tumors and tumor-like lesions in the pediatric population are uncommon. They comprise a heterogeneous group of infectious/inflammatory and neoplastic conditions. Pediatric salivary neoplasms include benign tumors of mesenchymal or epithelial origin as well as malignancies of epithelial (carcinomas), mesenchymal (sarcoma) or hematolymphoid (lymphoma) derivation. Infectious/inflammatory conditions and hematolymphoid malignancies may represent either genuine parenchymal pathology or conditions involving intraglandular lymph nodes of the parotid glands (intraglandular lymphadenopathy and intraglandular nodal lymphomas). Pediatric sialadenitis may be of diverse etiologies including viral (mumps, CMV, HIV, etc.), bacterial, autoimmune (juvenile Sjögren syndrome) or idiopathic (chronic recurrent juvenile sialectatic sialadenitis). Angiomatous lesions (juvenile capillary hemangioma, lymphangioma and vascular malformation) and pleomorphic adenomas represent the most common pediatric benign mesenchymal and benign epithelial tumors, respectively. The vast majority of salivary gland carcinomas in children and adolescents represent low-grade mucoepidermoid carcinomas followed by acinic cell and adenoid cystic carcinomas (together >80% of carcinomas). Other malignant neoplasms include (rhabdomyo-) sarcomas, malignant lymphomas and very rarely sialoblastomas. This long differential diagnosis list of etiologically and biologically highly heterogeneous entities, their shared clinical presentation as "salivary gland enlargement" and the significant differences in their therapeutic strategies and prognosis underline the need for careful assessment to identify the correct diagnosis. Diagnosis is mainly based on a set of typical clinical and imaging features, serological/microbiological findings and, in selected cases, histomorphological characteristics in biopsy specimens.

PMID: 28597093 [PubMed - indexed for MEDLINE]

Permalink for 'Indolent T-lymphoblastic proliferation concomitant with acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review.'

Indolent T-lymphoblastic proliferation concomitant with acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review.

Fetched: August 30th, 2018, 5:00am GMT

Indolent T-lymphoblastic proliferation concomitant with acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review.

Histopathology. 2018 Apr;72(5):862-866

Authors: Yasuda H, Tsutsui M, Ota Y, Tanaka M, Komatsu N

Abstract
AIMS: Indolent T-lymphoblastic proliferation (iT-LBP) is a non-clonal benign condition showing extrathymic proliferation of T-lymphoblasts positive for CD3, CD4, CD8, and TdT. Isolated iT-LBP has been observed, but the majority of iT-LBPs have been seen in conjunction with other disorders, including Castleman disease, hepatocellular carcinoma, follicular dendritic cell tumours, angioimmunoblastic T-cell lymphoma, myasthenia gravis, and acinic cell carcinoma (ACC). The clinical course of iT-LBP is indolent, and no therapy is usually required. A major concern is misdiagnosis as T-lymphoblastic lymphoma, and a correct diagnosis of iT-LBP often requires not only pathological analysis but also careful monitoring of the clinical course. The aim of this study was to broaden the knowledge of pathologists and physicians concerning this as yet not well-recognised entity.
METHODS AND RESULTS: We report a case of iT-LBP concomitant with ACC, along with a literature review of all 14 cases of iT-LBP reported to date.
CONCLUSIONS: iT-LBP should always be considered as a differential diagnosis of T-lymphoblastic lymphoma, as the two disorders show extremely similar traits.

PMID: 29143359 [PubMed - indexed for MEDLINE]

Permalink for 'High grade adenocarcinoma in the ectopic prostate accompanied by a low grade adenocarcinoma in the orthotopic prostate: an unusual diagnostic pitfall.'

High grade adenocarcinoma in the ectopic prostate accompanied by a low grade adenocarcinoma in the orthotopic prostate: an unusual diagnostic pitfall.

Fetched: August 26th, 2018, 5:00am GMT

High grade adenocarcinoma in the ectopic prostate accompanied by a low grade adenocarcinoma in the orthotopic prostate: an unusual diagnostic pitfall.

Pathology. 2017 Oct;49(6):665-668

Authors: Tolkach Y, Ellinger J, Müller S, Kristiansen G

PMID: 28830691 [PubMed - indexed for MEDLINE]

Pancreatic acinar cell carcinoma-induced panniculitis.

Fetched: August 23rd, 2018, 5:00am GMT

Pancreatic acinar cell carcinoma-induced panniculitis.

JAAD Case Rep. 2018 Aug;4(7):719-721

Authors: Singh S, Gorouhi F, Konia T, Burrall B

PMID: 30128347 [PubMed]

Prognostic value of epidermal growth factor receptor mutations and histologic subtypes with lung adenocarcinoma.

Fetched: August 19th, 2018, 5:00am GMT

Prognostic value of epidermal growth factor receptor mutations and histologic subtypes with lung adenocarcinoma.

Med Oncol. 2018 Jan 31;35(3):22

Authors: Motono N, Funasaki A, Sekimura A, Usuda K, Uramoto H

Abstract
The epidermal growth factor receptor (EGFR) mutation status has become one of the most important factors in the treatment of non-small cell lung cancer. However, the relationship between EGFR mutation and the histologic subtype of lung adenocarcinoma remains to be fully elucidated. We examined the relationship between the predominant subtype of adenocarcinoma and the prognosis and investigated the correlation between a new subtype of adenocarcinoma and EGFR mutations. This study included 182 patients with adenocarcinoma who underwent complete resection. The rate of EGFR mutation-positive patients was significantly higher among female patients, never smokers, patients with small tumors (< 3 cm in size), patients with well-differentiated tumors, and patients with a pStage I classification. The rates of adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and lepidic-predominant subtype were high in male EGFR mutation-positive patients. The prevalence of the acinar and papillary-predominant subtypes was high among EGFR mutation-positive female patients, as was AIS, MIA, and the lepidic-predominant subtype. The progression-free survival (PFS) of the EGFR mutation-positive patients was significantly better than that of the EGFR mutation-negative patients (75.8 vs 67.1%, p = 0.03). However, the multivariate analysis of clinicopathologic and histologic factors did not reveal the prognostic impact of the EGFR mutation status on PFS. The overall survival (OS) of the EGFR mutation-positive patients was significantly better than that of the EGFR mutation-negative patients (93.7 vs 63.4%, p < 0.01). However, in the multivariate analysis the EGFR mutation status was not significantly associated with OS.

PMID: 29387978 [PubMed - indexed for MEDLINE]

Permalink for '[Clinicopatholigic features of renal cell carcinoma associated with chromosome X inversion harboring gene fusions involving TFE3].'

[Clinicopatholigic features of renal cell carcinoma associated with chromosome X inversion harboring gene fusions involving TFE3].

Fetched: August 17th, 2018, 5:00am GMT

[Clinicopatholigic features of renal cell carcinoma associated with chromosome X inversion harboring gene fusions involving TFE3].

Zhonghua Bing Li Xue Za Zhi. 2018 Aug 08;47(8):574-579

Authors: Zhao YN, Wang XT, Xia QY, Wang GP, Sun SY, Zhao LF, Zhou XJ, Rao Q

Abstract
Objective: To study the clinicopathologic features, immunophenotype, characteristic FISH pattern and prognosis of renal cell carcinoma (RCC) associated with chromosome X inversion harboring gene fusions involving TFE3. Methods: Ten cases of NONO-TFE3 RCC and four cases of RBM10-TFE3 RCC were investigated at Nanjing Jinling Hospital from 2009 to 2016 by clinicopathological findings, immunohistochemistry, and genetic analysis. Results: Morphologically, the distinct pattern of secretory endometrioid subnuclear vacuolization was overlapped with clear cell papillary RCC, and often accompanied by sheets of epithelial cells in NONO-TFE3 RCC. Most cases of RBM10-TFE3 RCC presented with the biphasic feature that acinar, tubular and papillary patterns of epithelioid cells combined with sheets of small cells with "pseudorosette-like" architectures. In addition, cytoplasmic vacuolization, nuclear groove, and psammoma bodies were also observed. Immunohistochemically, all NONO-TFE3 RCC cases were immunoreactive for TFE3, CD10, RCC markers, and PAX8, and negative for CK7, Cathepsin K, Melan A, HMB45, Ksp-cadherin, vimentin, and CD117. All 4 cases of RBM10-TFE3 RCC showed moderate to strong immunoreactivity for TFE3, Cathepsin K, CD10, Ksp-cadherin, E-cadherin, P504s, RCC marker, PAX8, and vimentin but negative for TFEB, HMB45 and CK7. CKpan and Melan A were at least focally expressed. The antibody to Ki-67 showed labeling of 3%-8% (mean 5%). There were some expression discrepancies of immunochemistry between different histological patterns. PAX8, CKpan, P504s, and Ksp-cadherin were expressed in epithelioid areas but not in small-cell areas. Ki-67 labeling index of epithelioid areas was higher than that in small-cell areas. In molecular analysis, NONO-TFE3 fusion transcripts were identified in 6 patients. The fusion points were between exon 7 of NONO and exon 6 of TFE3 in 5 patients and between exon 9 of NONO and exon 5 of TFE3 in one patient. All 4 cases of RBM10-TFE3 RCC demonstrated to have RBM10-TFE3 fusion transcripts and the fusion points were between exon 5 of TFE3 and exon 17 of RBM10. Using TFE3 break-apart FISH assay, all 10 cases of NONO-TFE3 RCC showed characteristic patterns of equivocal split signals with a distance of nearly 2 signal diameters. All 4 cases of RBM10-TFE3 RCC showed colocalized or subtle split signals with a distance of <1 signal diameter, which was considered as negative results. Long-term follow-up was available for 7 patients of NONO-TFE3 RCC and 4 patients of RBM10-TFE3 RCC. All patients were alive with no evidence of disease. Conclusions: Two rare genotypes, NONO-TFE3 RCC and RBM10-TFE3 RCC, are reported in this study. Both of these two tumors show specific morphology and good prognosis, along with the positive TFE3 staining and the equivocal or false-negative TFE3 FISH results, which could be missed. PCR detection or next-generation sequencing can determine the genotype.

PMID: 30107660 [PubMed - in process]

Pancreatic Acinar Cell Carcinoma with Multiple Liver Metastases Effectively Treated by S-1 Chemotherapy.

Fetched: August 15th, 2018, 5:00am GMT

Pancreatic Acinar Cell Carcinoma with Multiple Liver Metastases Effectively Treated by S-1 Chemotherapy.

Intern Med. 2018 Aug 10;:

Authors: Yoshida N, Kanno A, Masamune A, Nabeshima T, Hongo S, Miura S, Takikawa T, Hamada S, Kikuta K, Kume K, Ueno M, Shimosegawa T

Abstract
A 79-year-old woman was referred for pancreatic tail cancer with multiple liver metastases. The pancreatic tail tumor was diagnosed as acinar cell carcinoma (ACC) histologically by endoscopic ultrasound-guided fine-needle aspiration. Because of multiple liver metastases, S-1 chemotherapy was administered, resulting in a partial response to chemotherapy one year later. After approximately three years, liver atrophy and esophageal varices developed. We suspected S-1 as the cause of the liver cirrhosis. S-1 cessation minimized ascites and improved the esophageal varices. Although S-1 can potentially treat ACC, we should be watchful for liver cirrhosis caused by its long-term administration.

PMID: 30101903 [PubMed - as supplied by publisher]

Pancreatic Mass in a Patient With an Increased Serum Level of IgG4.

Fetched: August 10th, 2018, 5:00am GMT

Pancreatic Mass in a Patient With an Increased Serum Level of IgG4.

Gastroenterology. 2018 08;155(2):269-270

Authors: Matsumori T, Shiokawa M, Kodama Y

PMID: 29410043 [PubMed - indexed for MEDLINE]

[Clinicopathologic and molecular genetic analysis of secretory carcinoma of salivary gland].

Fetched: August 9th, 2018, 5:00am GMT

[Clinicopathologic and molecular genetic analysis of secretory carcinoma of salivary gland].

Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 Aug 09;53(8):533-538

Authors: Zhao M, Zhao DH, Cheng G, Yan YJ, Wang Z, He XL

Abstract
Objective: To investigate the clinicopathologic and molecular genetic features of secretory carcinoma of salivary gland (SCSG). Methods: Six cases of SCSG were collected from Zhejiang Provincial People's Hospital from January 2011 to March 2018. The clinical, histopathological and immunohistochemical features were analyzed and fluorescence in situ hybridization (FISH) was used to detect ETV6 gene rearrangement. Results: Four out of 6 tumors originated in the parotid gland and one of each in the minor salivary glands of soft palate and the buccal mucosa. Grossly, 4 cases were solid and 2 were partially cystic with maximum diameter ranging from 1.0 to 4.0 cm. Microscopically, 5 tumors showed typical features of low grade SCSG with tumor divided by thin fibrous septa into lobules composed of solid acinar, microcystic, follicular and papillary structures with abundant extracellular mucinous secretions. The tumor cells had cuolated or hobnail cytoplasm with low-grade nuclei and scarce mitoses. Perineural invasion was present in 1 case. The remaining tumor showed about 30% of the tumor areas with high-grade transformation characterized by proliferation of a distinct population of anaplastic cells arranged in irregular glandular, small nested and single cell patterns that were surrounded by desmoplastic stroma and invaded into surface mucosa with ulceration. Immunohistochemistry showed that all 6 tumors had diffuse and strong reactivities to S100 protein and cytokeratin 7, and 4 cases showed focal reactivity to gross cystic disease fluid protein 15 (GCDFP15), all were negative for discovered on gist 1 (DOG1), cytokeratin 20, p63 and calponin. High grade transformation cases were analysed, the high grade SCSG components showed a significantly increased Ki-67 index and cyclin D1 positive tumor cells compared to the conventional SCSG components. FISH analyses showed that 4 cases had ETV6 gene rearrangement. Eleven to seventy one months' follow-up showed no evidence of tumor recurrence nor metastasis. Conclusions: SCSG harbors characteristic genetic abnormalities with ETV6 gene rearrangement and typically shows a low grade morphology with occasionally, high grade transformation can be present.

PMID: 30078266 [PubMed - in process]

Acinic cell carcinoma of minor salivary glands - case report.

Fetched: August 9th, 2018, 5:00am GMT

Acinic cell carcinoma of minor salivary glands - case report.

Rom J Morphol Embryol. 2017;58(3):1003-1007

Authors: Buhaş CL, Roşca E, MuŢiu G, Venter AC, Buhaş BA, CouŢi R, Ciobanu CF, Roşca DM

Abstract
Salivary gland tumors have a high incidence (90%) within the parotid gland. The acinic cell carcinoma (ACC) represents only 1-3% of the salivary gland tumors, most frequently affecting the parotid. The minor salivary glands rarely develop ACC and when the ACC is localized in these glands, generally, it has a less aggressive evolution. The main criterion in the diagnostic of ACC is the histological examination with the regular Hematoxylin-Eosin (HE) staining and additionally Periodic Acid-Schiff (PAS) special staining. Immunohistochemical (IHC) examination confirms the origin of the tumor cells and the cellular proliferation index. Therapeutic management consists of surgical excision and radiotherapy. Left jugular tumor was the clinical diagnosis in the case we presented. The computed tomography (CT) examination revealed a voluminous expansive process of the left cheek. Surgery was performed with tumor resection and the skin defect was threatened. The histopathological (HP) and IHC exams have established the diagnosis of minor salivary glands adenocarcinoma with increased tumor proliferation index. The evolution was unfavorable to tumor recurrence in a short time of one year.

PMID: 29250681 [PubMed - indexed for MEDLINE]

Surgical resection of hepatic and rectal metastases of pancreatic acinar cell carcinoma (PACC): a case report.

Fetched: August 7th, 2018, 5:00am GMT

Surgical resection of hepatic and rectal metastases of pancreatic acinar cell carcinoma (PACC): a case report.

World J Surg Oncol. 2018 Aug 03;16(1):158

Authors: Ohara Y, Oda T, Enomoto T, Hisakura K, Akashi Y, Ogawa K, Owada Y, Domoto Y, Miyazaki Y, Shimomura O, Kurata M, Ohkohchi N

Abstract
BACKGROUND: Pancreatic acinar cell carcinoma (PACC), a rare variant of pancreatic malignancy, is generally managed the same way as pancreatic ductal adenocarcinoma (PDAC). Surgical resection is the gateway to curing it; however, once it metastasizes (usually to the liver, lungs, lymph nodes, or peritoneal cavity), systemic chemotherapy has been the only option, but with unfavorable results.
CASE PRESENTATION: A 67-year-old man with symptoms of loss of appetite and weight underwent surgery for malignancy of the pancreatic tail extending into the entire pancreas. The pathological diagnosis was PACC following total pancreatectomy. Twenty-four months after the pancreatectomy, a solitary liver metastasis was treated by partial hepatectomy, and, subsequently, 4 months later, he presented with melena. Further examination revealed a type-2 rectal tumor. Histological examination following biopsy revealed it to be rectal metastasis of PACC, and it was treated by abdominoperineal resection. Subsequently, the patient did not have tumor recurrence as of 40 months after pancreatectomy.
CONCLUSIONS: This is a rare case of PACC presenting with metachronal metastases in the liver and rectum, and we successfully treated them by surgical resections. Since the malignant behavior of PACC is usually less than that of PDAC, surgical resection could be an option even for metastatic lesions when the number and extent of metastases are limited.

PMID: 30075727 [PubMed - in process]

Acelarin First Line Randomised Pancreatic Study

Posted: August 1st, 2018, 2:00pm GMT

Conditions: Pancreatic Acinar Carcinoma; Pancreatic Neoplasms
Interventions: Drug: Acelarin; Drug: Gemcitabine
Sponsors: The Clatterbridge Cancer Centre NHS Foundation Trust; Cancer Research UK; University of Liverpool
Recruiting

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

Posted: July 15th, 2016, 2:00pm GMT

Conditions: Acinar Cell Carcinoma; Adenoid Cystic Carcinoma; Adrenal Cortex Carcinoma; Adrenal Gland Pheochromocytoma; Anal Canal Neuroendocrine Carcinoma; Anal Canal Undifferentiated Carcinoma; Appendix Mucinous Adenocarcinoma; Bartholin Gland Transitional Cell Carcinoma; Bladder Adenocarcinoma; Cervical Adenocarcinoma; Cholangiocarcinoma; Chordoma; Colorectal Squamous Cell Carcinoma; Desmoid-Type Fibromatosis; Endometrial Transitional Cell Carcinoma; Endometrioid Adenocarcinoma; Esophageal Neuroendocrine Carcinoma; Esophageal Undifferentiated Carcinoma; Extrahepatic Bile Duct Carcinoma; Fallopian Tube Adenocarcinoma; Fallopian Tube Transitional Cell Carcinoma; Fibromyxoid Tumor; Gastric Neuroendocrine Carcinoma; Gastric Squamous Cell Carcinoma; Gastric Undifferentiated Carcinoma; Gastrointestinal Stromal Tumor; Giant Cell Carcinoma; Intestinal Neuroendocrine Carcinoma; Intrahepatic Cholangiocarcinoma; Lung Carcinoid Tumor; Lung Sarcomatoid Carcinoma; Major Salivary Gland Carcinoma; Malignant Odontogenic Neoplasm; Malignant Peripheral Nerve Sheath Tumor; Malignant Testicular Sex Cord-Stromal Tumor; Metaplastic Breast Carcinoma; Metastatic Malignant Neoplasm of Unknown Primary Origin; Minimally Invasive Lung Adenocarcinoma; Mixed Mesodermal (Mullerian) Tumor; Mucinous Adenocarcinoma; Mucinous Cystadenocarcinoma; Nasal Cavity Adenocarcinoma; Nasal Cavity Carcinoma; Nasopharyngeal Carcinoma; Nasopharyngeal Papillary Adenocarcinoma; Nasopharyngeal Undifferentiated Carcinoma; Oral Cavity Carcinoma; Oropharyngeal Undifferentiated Carcinoma; Ovarian Adenocarcinoma; Ovarian Germ Cell Tumor; Ovarian Mucinous Adenocarcinoma; Ovarian Squamous Cell Carcinoma; Ovarian Transitional Cell Carcinoma; Pancreatic Acinar Cell Carcinoma; Pancreatic Neuroendocrine Carcinoma; Paraganglioma; Paranasal Sinus Adenocarcinoma; Paranasal Sinus Carcinoma; Parathyroid Gland Carcinoma; Pituitary Gland Carcinoma; Placental Choriocarcinoma; Placental-Site Gestational Trophoblastic Tumor; Primary Peritoneal High Grade Serous Adenocarcinoma; Pseudomyxoma Peritonei; Rare Disorder; Scrotal Squamous Cell Carcinoma; Seminal Vesicle Adenocarcinoma; Seminoma; Serous Cystadenocarcinoma; Small Intestinal Adenocarcinoma; Small Intestinal Squamous Cell Carcinoma; Spindle Cell Neoplasm; Squamous Cell Carcinoma of the Penis; Teratoma With Malignant Transformation; Testicular Non-Seminomatous Germ Cell Tumor; Thyroid Gland Carcinoma; Tracheal Carcinoma; Transitional Cell Carcinoma; Ureter Adenocarcinoma; Ureter Squamous Cell Carcinoma; Urethral Adenocarcinoma; Urethral Squamous Cell Carcinoma; Vaginal Adenocarcinoma; Vaginal Squamous Cell Carcinoma, Not Otherwise Specified; Vulvar Carcinoma
Interventions: Procedure: Biospecimen Collection; Biological: Ipilimumab; Biological: Nivolumab
Sponsor: National Cancer Institute (NCI)
Recruiting

This RSS feed URL is deprecated

Posted: August 30th, 2018, 5:00am GMT

This RSS feed URL is deprecated, please update. New URLs can be found in the footers at [https:]

Acinic Cell Carcinoma - News-Medical.net

Posted: June 20th, 2018, 11:28pm GMT

News-Medical.net

The Spectrum of Triple-Negative Breast Disease - Am J Pathology

Posted: July 21st, 2017, 10:03pm GMT

Am J Pathology

The Spectrum of Triple-Negative Breast Disease
Am J Pathology
Whereas fairly common in acinic cell carcinoma, it is a rare event in the salivary gland–like tumors of the breast and solid papillary carcinoma with reverse polarity. ∗It should be noted that evidence for the presence of PRKD1 E710D mutations or PRKD1 ...

Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype - Nature.com

Posted: August 20th, 2015, 7:27am GMT

Nature.com

Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype
Nature.com
Diegel, C. R., Cho, K. R., El-Naggar, A. K., Williams, B. O. & Lindvall, C. Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma ...

The Squamous Cells of Adenosquamous Carcinoma (ASCC) of the Prostate Might Represent a Terminally Differentiated Quiescent Component: Immunohistochemical Evidence From a Case of ASCC With Pleomorphic Giant Tumor Cells.

Fetched: September 21st, 2018, 5:00am GMT

Appl Immunohistochem Mol Morphol. 2017 09;25(8):e71-e73

Authors: Acosta AM, Kajdacsy-Balla A, Groth JV

PMID: 27753662 [PubMed - indexed for MEDLINE]

Hemorrhage of MRI and Immunohistochemical Panels Distinguish Secretory Carcinoma From Acinic Cell Carcinoma.

Fetched: September 8th, 2018, 5:00am GMT

Hemorrhage of MRI and Immunohistochemical Panels Distinguish Secretory Carcinoma From Acinic Cell Carcinoma.

Laryngoscope Investig Otolaryngol. 2018 Aug;3(4):268-274

Authors: Kuwabara H, Yamamoto K, Terada T, Kawata R, Nagao T, Hirose Y

Abstract
Objectives: Secretory carcinoma (SC, mammary analogue secretory carcinoma) is a salivary gland tumor with ETV6-NTRK3 gene fusion, and its differential diagnosis includes acinic cell carcinoma (ACC). As hemorrhage is often seen in SC, we hypothesized that magnetic resonance imaging (MRI) and immunohistochemical analyses could distinguish SC from ACC.
Study Design: Retrospective study.
Methods: We used ETV6-NTRK3 gene fusion analyses to reclassify 19 parotid gland tumors that had previously been diagnosed as SC or ACC, and then investigated hemorrhage in both hematoxylin-eosin (H&E)-stained sections and MRIs, and immunohistochemical expression of S-100, mammaglobin, DOG1, and α-amylase.
Results: The 19 tumors were genetically reclassified into 11 (58%) SC and 8 (42%) ACC. Combined S-100 and mammaglobin were specific for SC; whereas DOG1 was specific for ACC, and α-amylase was expressed only in 4 ACC cases (50%). H&E staining showed hemorrhage with hemosiderin deposition in all SC cases, and T2-weighted MRI showed hypointense areas in all investigated SC cases, but not in ACC.
Conclusion: Hemorrhage with hemosiderin deposition is frequently present in SC, and hemorrhage findings in MRI and an immunohistochemical panels for S-100, mammaglobin and DOG1 can distinguish SC from ACC.
Level of Evidence: 3b.

PMID: 30186957 [PubMed]

[Pediatric salivary gland tumors and tumor-like lesions].

Fetched: August 31st, 2018, 5:00am GMT

[Pediatric salivary gland tumors and tumor-like lesions].

Pathologe. 2017 Jul;38(4):294-302

Authors: Agaimy A, Iro H, Zenk J

PMID: 28597093 [PubMed - indexed for MEDLINE]

High grade adenocarcinoma in the ectopic prostate accompanied by a low grade adenocarcinoma in the orthotopic prostate: an unusual diagnostic pitfall.

Fetched: August 26th, 2018, 5:00am GMT

High grade adenocarcinoma in the ectopic prostate accompanied by a low grade adenocarcinoma in the orthotopic prostate: an unusual diagnostic pitfall.

Pathology. 2017 Oct;49(6):665-668

Authors: Tolkach Y, Ellinger J, Müller S, Kristiansen G

PMID: 28830691 [PubMed - indexed for MEDLINE]

Pancreatic acinar cell carcinoma-induced panniculitis.

Fetched: August 23rd, 2018, 5:00am GMT

Pancreatic acinar cell carcinoma-induced panniculitis.

JAAD Case Rep. 2018 Aug;4(7):719-721

Authors: Singh S, Gorouhi F, Konia T, Burrall B

PMID: 30128347 [PubMed]

Prognostic value of epidermal growth factor receptor mutations and histologic subtypes with lung adenocarcinoma.

Fetched: August 19th, 2018, 5:00am GMT

Prognostic value of epidermal growth factor receptor mutations and histologic subtypes with lung adenocarcinoma.

Med Oncol. 2018 Jan 31;35(3):22

Authors: Motono N, Funasaki A, Sekimura A, Usuda K, Uramoto H

PMID: 29387978 [PubMed - indexed for MEDLINE]

[Clinicopatholigic features of renal cell carcinoma associated with chromosome X inversion harboring gene fusions involving TFE3].

Fetched: August 17th, 2018, 5:00am GMT

[Clinicopatholigic features of renal cell carcinoma associated with chromosome X inversion harboring gene fusions involving TFE3].

Zhonghua Bing Li Xue Za Zhi. 2018 Aug 08;47(8):574-579

Authors: Zhao YN, Wang XT, Xia QY, Wang GP, Sun SY, Zhao LF, Zhou XJ, Rao Q

PMID: 30107660 [PubMed - in process]

Pancreatic Acinar Cell Carcinoma with Multiple Liver Metastases Effectively Treated by S-1 Chemotherapy.

Fetched: August 15th, 2018, 5:00am GMT

Pancreatic Acinar Cell Carcinoma with Multiple Liver Metastases Effectively Treated by S-1 Chemotherapy.

Intern Med. 2018 Aug 10;:

Authors: Yoshida N, Kanno A, Masamune A, Nabeshima T, Hongo S, Miura S, Takikawa T, Hamada S, Kikuta K, Kume K, Ueno M, Shimosegawa T

PMID: 30101903 [PubMed - as supplied by publisher]

Pancreatic Mass in a Patient With an Increased Serum Level of IgG4.

Fetched: August 10th, 2018, 5:00am GMT

Pancreatic Mass in a Patient With an Increased Serum Level of IgG4.

Gastroenterology. 2018 08;155(2):269-270

Authors: Matsumori T, Shiokawa M, Kodama Y

PMID: 29410043 [PubMed - indexed for MEDLINE]

[Clinicopathologic and molecular genetic analysis of secretory carcinoma of salivary gland].

Fetched: August 8th, 2018, 5:00am GMT

[Clinicopathologic and molecular genetic analysis of secretory carcinoma of salivary gland].

Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 Aug 09;53(8):533-538

Authors: Zhao M, Zhao DH, Cheng G, Yan YJ, Wang Z, He XL

PMID: 30078266 [PubMed - in process]

Surgical resection of hepatic and rectal metastases of pancreatic acinar cell carcinoma (PACC): a case report.

Fetched: August 6th, 2018, 5:00am GMT

Surgical resection of hepatic and rectal metastases of pancreatic acinar cell carcinoma (PACC): a case report.

World J Surg Oncol. 2018 Aug 03;16(1):158

Authors: Ohara Y, Oda T, Enomoto T, Hisakura K, Akashi Y, Ogawa K, Owada Y, Domoto Y, Miyazaki Y, Shimomura O, Kurata M, Ohkohchi N

PMID: 30075727 [PubMed - in process]

Latest Industry: Paul McCartney, YouTube, Viagogo, Caffeine, BTS, BMGPM, RCA, James Grant Group, More… - Digital Music News

Posted: September 6th, 2018, 9:54pm GMT

Digital Music News

Latest Industry: Paul McCartney, YouTube, Viagogo, Caffeine, BTS, BMGPM, RCA, James Grant Group, More…
Digital Music News
His family revealed last year Camillo battled Adenoid Cystic Carcinoma. Camilo worked with multiple major artists in the 70s, including Gladys Knight and the Pips, Eric Carmen, Dionne Warwick, Stevie Wonder, Grand Funk Railroad, Peaches and Herbs, and ...

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Posted: August 30th, 2018, 5:00am GMT

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Rare Subtypes of Epithelial Mesothelioma - Mesothelioma.net Blog (blog)

Posted: August 9th, 2018, 6:43pm GMT

Rare Subtypes of Epithelial Mesothelioma
Mesothelioma.net Blog (blog)
This can easily be misdiagnosed as adenoid cystic carcinoma and adenocarcinoma. Signet ring. The rare signet ring form of epithelial mesothelioma cells are characterized by the presence of a large vacuole, a space or cavity within the cell. This makes ...

New York Man Shares Journey After Being Diagnosed with Aggressive Cancer He Thought Was Jaw Pain - PEOPLE.com

Posted: August 3rd, 2018, 3:29pm GMT

PEOPLE.com

New York Man Shares Journey After Being Diagnosed with Aggressive Cancer He Thought Was Jaw Pain
PEOPLE.com
In a few days time, Powell learned he was diagnosed with Stage IV Adenoid Cystic Carcinoma, an aggressive cancer that begins in glandular tissues, most commonly those found in the oral cavity. While tumors may not cause pain in their early stages, ...

Permalink for 'SOX11: A Potentially Useful Marker in Surgical Pathology A Systematic Analysis of SOX11 Expression in Epithelial and Nonepithelial Tumors.'

SOX11: A Potentially Useful Marker in Surgical Pathology A Systematic Analysis of SOX11 Expression in Epithelial and Nonepithelial Tumors.

Fetched: September 19th, 2018, 5:00am GMT

SOX11: A Potentially Useful Marker in Surgical Pathology A Systematic Analysis of SOX11 Expression in Epithelial and Nonepithelial Tumors.

Histopathology. 2018 Sep 17;:

Authors: Xu S, Dong Y, Huo Z, Yu L, Xue J, Wang G, Duan Y

Abstract
AIMS: SOX11 is known as an essential transcription factor for regulating neurogenesis. Recently, SOX11 has been suggested to be a diagnostic marker and oncogene because of its significant expression in mantle cell lymphoma (MCL). However, SOX11 expression in other tumor types has not been extensively studied yet.
MATERIALS AND METHODS: Herein, we examined SOX11 expression in 2026 cases of neuroectodermal, germ cell, mesenchymal, and epithelial tumors by immunohistochemistry.
RESULTS: SOX11 was consistently expressed in all neuroectodermal tumors with neural differentiation as well as in immature teratomas revealing neurogenesis. Less frequently, SOX11 expression was only observed in 50% of astrocytomas and 24% of malignant peripheral nerve sheath tumors, and mostly was sporadic and weak/intermediate. In epithelial tumors, significant SOX11 expression was identified in 97% of salivary ductal carcinomas (SDCs) and a high percentage of high-grade neuroendocrine carcinomas (NECs), especially the small cell lung carcinomas (68%), and was absent in most other carcinomas, except for less and/or focal and weak expression in adenocarcinomas from the lung, genital tract, and breast, and salivary adenoid cystic carcinomas and epithelial-myoepithelial carcinomas. In mesenchymal tumors, in addition to MCLs, prominent SOX11 expression was observed in 90% of rhabdomyosarcomas, and all myxoid/round liposarcomas (MRCLs). Less frequent and/or focal and weak expression was observed in lymphoblastic, Burkitt and follicular lymphomas, synovial sarcoma and angiosarcoma.
CONCLUSION: SOX11 showed prominent expression in neuroectodermal tumors with neural differentiation, high grade-NEC, SDC, rhabdomyosarcoma and MRCL. The high sensitivity and specificity of SOX11 in SDC and MRCL make it a useful diagnostic marker. This article is protected by copyright. All rights reserved.

PMID: 30221780 [PubMed - as supplied by publisher]

[Basaloid squamous cell carcinoma of the cervix with adenoid cystic cancer features: a clinicopathologic analysis of 3 cases].

Fetched: September 19th, 2018, 5:00am GMT

[Basaloid squamous cell carcinoma of the cervix with adenoid cystic cancer features: a clinicopathologic analysis of 3 cases].

Zhonghua Bing Li Xue Za Zhi. 2018 Sep 08;47(9):719-720

Authors: Liang Y, Chen XD, Zhang XF, Yu MH, Zhou CY

PMID: 30220129 [PubMed - in process]

[Clinicopathologic features and prognosis of adenoid cystic carcinoma of external auditory meatus].

Fetched: September 19th, 2018, 5:00am GMT

[Clinicopathologic features and prognosis of adenoid cystic carcinoma of external auditory meatus].

Zhonghua Bing Li Xue Za Zhi. 2018 Sep 08;47(9):691-695

Authors: Gou XN, Li J, Wang XC, Liu Y, Qiu XM, Shi HY

Abstract
Objective: To investigate clinicopathologic features and prognosis of adenoid cystic carcinoma (ACC) involving external auditory meatus. Methods: The clinical presentation and follow-up data of 63 patients with ACC of external auditory canal were collected from January 2006 to February 2017 at PLA General Hospital and Hainan Branch of PLA General Hospital. The clinicopathologic features and prognostic factors of external auditory canal ACC were analyzed. Results: (1) There were 28 males and 35 females and the average age of the first diagnosis was 48.9 years (22-81 years). The tumors showed cribriform pattern in 35 cases (15 cases of late stage), tubular pattern in 14 cases (8 cases of late stage), and solid pattern in 14 cases (9 cases of late stage). Cases with solid pattern was relatively more frequent than that of cribriform pattern and tubular pattern, but the difference was not statistically significant (P>0.05). (2) The average follow-up time was 62.4 months (2-228 months) in the 57 available cases. Among the 33 cases with recurrence, 18 cases had local recurrence and 15 cases had distant metastasis. The mean recurrence time was 40.6 months (2-204 months). Nine patients died of ACC: 2 cases in early stage (died at 48 and 102 months after the first treatment), 7 cases in late stage and 57 with (died at 9, 30, 32, 60, 72, 94 and 228 months). (3) Among the 37 patients with perineural invasion, there were 21 cases of cribriform pattern, 4 cases of tubular pattern and 12 cases of solid pattern; the number of cases in early stage and late stage were 15 and 22, respectively; and the differences were statistically significant (P<0.05). In addition, 31 cases had otalgia among the 37 patients with perineural invasion, where differences were not significant (P>0.05). (4) Thirty of 45 cases with tumor resection or partial resection of temporal bone had recurrence, whereas 3 of 12 cases of tumor combined with superficial lobectomy of parotid gland had recurrence. The difference was statistically significant (P<0.05). Postoperative adjuvant radiotherapy was given in 19 cases, including 7 cases of early stage (2 cases of recurrence), and 12 cases of late stage (8 cases of recurrence), among which there was no significant difference (P>0.05). Conclusions: ACC occurring in external auditory canal frequently recurs. Superficial parotid lobectomy at the first operation is necessary to prevent tumor recurrence. Postoperative adjuvant radiotherapy has certain curative effect on patients with early stage tumor, but it does not affect the recurrence rate. Patients at late stage are more prone to perineural invasion than those in early stage. In addition, cribriform and solid patterns are more common that tubular pattern, and there is no significant correlation between perineural invasion and otalgia.

PMID: 30220123 [PubMed - in process]

[Adenocystic carcinoma of the trachea].

Fetched: September 19th, 2018, 5:00am GMT

[Adenocystic carcinoma of the trachea].

Khirurgiia (Mosk). 2016;(11. Vyp. 2):4-11

Authors: Kharchenko VP, Chkhikvadze VD, Gvarishvili AA, Pan'shin GA

Abstract
It is presented 40-years experience of tracheal adenocystic carcinoma diagnosis and management in 144 patients. Peculiarities of clinical course and choice of diagnostic and therapeutic measures are discussed in relation to stenosis and hypoxia degree and severity of accompanying inflammatory complications of trachea, bronchi and lungs. Technical tools and original methods of resection and reconstruction of trachea and it's bifurcation after extended lung resection are described. Surgical management is carried out in 96 patients: all patients underwent circular resection of trachea (77) or it's bifurcation (19). Morbidity rate was 22.9% and mortality - 3.1%. Additional radiotherapy was carried out in 50 patients. 41 patients underwent radiotherapy alone. Radiotherapy improves remote results of management. 5-and 10-year survival rate was 78.3±6.1 and 45.9±7.9% after surgery alone, 92.0±3.9 and 77.1±6.5% after combined treatment and 76.4±6.5 and 55.0±10.7% after radiotherapy alone respectively.

PMID: 28008895 [PubMed - indexed for MEDLINE]

Upregulation of lncRNA ADAMTS9-AS2 Promotes Salivary Adenoid Cystic Carcinoma Metastasis via PI3K/Akt and MEK/Erk Signaling.

Fetched: September 17th, 2018, 5:00am GMT

Upregulation of lncRNA ADAMTS9-AS2 Promotes Salivary Adenoid Cystic Carcinoma Metastasis via PI3K/Akt and MEK/Erk Signaling.

Mol Ther. 2018 Aug 24;:

Authors: Xie S, Yu X, Li Y, Ma H, Fan S, Chen W, Pan G, Wang W, Zhang H, Li J, Lin Z

Abstract
Neurotropic infiltrative growth and distant metastasis are the main causes of death in salivary adenoid cystic carcinoma (SACC) patients. Long noncoding RNAs (lncRNAs) are involved in many human neoplasms, however, their potential roles in SACC are unclear. In our study, we found that ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9) antisense RNA 2 (ADAMTS9-AS2) was significantly upregulated in SACC patients with metastasis and SACC-lung metastasis (LM) cells. Moreover, ADAMTS9-AS2 expression was closely associated with the prognosis and distant metastasis in SACC patients. Next, we found that c-myc could specifically bind to the promoter of ADAMTS9-AS2 and activated its transcription. Knockdown of ADAMTS9-AS2 significantly inhibited migration and invasion of SACC cells in vitro and distant lung metastasis in vivo. Furthermore, ADAMTS9-AS2, which mainly expressed in the cytoplasm, shared microRNA (miRNA) response elements with Integrin α6 (ITGA6). Overexpression of ADAMTS9-AS2 competitively bound to miR-143-3p that inhibited ITGA6 from miRNA-mediated degradation, and thus it activated the activity of PI3K/Akt and MEK/Erk signaling and facilitated SACC metastasis. In summary, ADAMTS9-AS2 promotes migration and invasion in SACC by competing with miR-143-3p. This sheds a new insight into the regulation mechanism of ADAMTS9-AS2, and it provides a possible application for the SACC treatment.

PMID: 30217729 [PubMed - as supplied by publisher]

A Rare Case of Adenoid Cystic Carcinoma of the Sphenoid Sinus Presenting with Lateral Rectus Palsy.

Fetched: September 15th, 2018, 5:00am GMT

A Rare Case of Adenoid Cystic Carcinoma of the Sphenoid Sinus Presenting with Lateral Rectus Palsy.

Indian J Otolaryngol Head Neck Surg. 2018 Sep;70(3):459-461

Authors: Lasrado S, Moras K, Prabha BB

Abstract
A rare case of adenoid cystic carcinoma arising from the sphenoid sinus causing lateral rectus palsy is presented here. Adenoid cystic carcinoma of the paranasal sinuses is an aggressive neoplasm which needs early diagnosis and treatment. Ideal treatment paradigm for paranasal sinus tumors is yet to be established. A combination of surgery and radiotherapy offers a better disease control and survival.

PMID: 30211109 [PubMed]

Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma.

Fetched: September 15th, 2018, 5:00am GMT

Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma.

J Exp Med. 2018 Sep 12;:

Authors: Mandelbaum J, Shestopalov IA, Henderson RE, Chau NG, Knoechel B, Wick MJ, Zon LI

Abstract
Pluripotent cells have been used to probe developmental pathways that are involved in genetic diseases and oncogenic events. To find new therapies that would target MYB-driven tumors, we developed a pluripotent zebrafish blastomere culture system. We performed a chemical genetic screen and identified retinoic acid agonists as suppressors of c-myb expression. Retinoic acid treatment also decreased c-myb gene expression in human leukemia cells. Translocations that drive overexpression of the oncogenic transcription factor MYB are molecular hallmarks of adenoid cystic carcinoma (ACC), a malignant salivary gland tumor with no effective therapy. Retinoic acid agonists inhibited tumor growth in vivo in ACC patient-derived xenograft models and decreased MYB binding at translocated enhancers, thereby potentially diminishing the MYB positive feedback loop driving ACC. Our findings establish the zebrafish pluripotent cell culture system as a method to identify modulators of tumor formation, particularly establishing retinoic acid as a potential new effective therapy for ACC.

PMID: 30209067 [PubMed - as supplied by publisher]

The MYB/miR-130a/NDRG2 axis modulates tumor proliferation and metastatic potential in salivary adenoid cystic carcinoma.

Fetched: September 14th, 2018, 5:00am GMT

The MYB/miR-130a/NDRG2 axis modulates tumor proliferation and metastatic potential in salivary adenoid cystic carcinoma.

Cell Death Dis. 2018 Sep 11;9(9):917

Authors: Wang Y, Zhang CY, Xia RH, Han J, Sun B, Sun SY, Li J

Abstract
Increasing evidence has emerged to suggest that N-myc downstream-regulated gene 2 (NDRG2) dysregulation participates in a number of tumor biological processes. However, the role of NDRG2 and miRNA-mediated NDRG2 regulation in salivary adenoid cystic carcinoma (SACC) progression remain unknown. Here, we determined that SACC tissues exhibited decreased level of NDRG2, which was associated with poorer rates of overall survival and distant metastasis-free survival. Silencing NDRG2 promoted SACC cell proliferation and metastasis both in vitro and in vivo. MiRNAs have been reported as vital regulators of NDRG2 expression. Based on micronome sequencing of three paired samples of SACC and normal salivary gland tissue and on an online database analysis, miR-130a was identified as a candidate miRNA that potentially regulates NDRG2. We demonstrated that the expression level of NDRG2 was dramatically reduced by exogenous miR-130a. Moreover, a luciferase assay further validated that miR-130a could degrade NDRG2 mRNA by targeting sites in the NDRG2 3'UTR. A rescue experiment suggested that NDRG2 expression could reverse the miR-130a-mediated promotion of cell proliferation and invasion. The expression of miR-130a has been reported to be regulated by certain transcription factors. In the preset study, we verified that the transcription factor MYB acted as the critical driver in SACC-upregulated miR-130a expression directly and induced NDRG2 downregulation in SACC tissues. Additionally, MYB/miR-130a activated the STAT3 and AKT pathways by downregulating NDRG2. These observations suggest that the MYB/miR-130a/NDRG2 axis, which modulates proliferation and metastasis in SACC, provides promising targets for the treatment of SACC.

PMID: 30206227 [PubMed - in process]

A Staged Procedure in the Treatment of Primary Lacrimal Sac Epithelial Malignancy: A Retrospective Cases Analysis.

Fetched: September 13th, 2018, 5:00am GMT

A Staged Procedure in the Treatment of Primary Lacrimal Sac Epithelial Malignancy: A Retrospective Cases Analysis.

Ophthalmic Plast Reconstr Surg. 2018 Sep 06;:

Authors: Zhang R, Qian J, Meng F, Yuan Y, Bai M, Bi Y, Xu B, Yuan Y, Hong R

Abstract
PURPOSE: To determine the effect of a staged procedure in the treatment of primary lacrimal sac epithelial malignancy.
METHODS: This is a retrospective case series of 18 consecutive patients with primary lacrimal sac epithelial malignancy treated at an orbital tumor referral center between 2002 and 2017. Study was conducted in compliance with the Declaration of Helsinki. All patients underwent biopsy of the mass to confirm the diagnosis pathologically. Chemotherapy concurrent with radiotherapy was delivered to the patients to reduce and concrete the tumor prior to surgery. En bloc resection of the lacrimal sac malignancy and nasolacrimal duct was followed.
RESULTS: Eleven patients were male and 7 patients were female. The median follow-up time was 72.2 months. Nine patients had squamous cell carcinoma, 7 poorly differentiated carcinoma, 1 transitional cell carcinoma, and 1 adenoid cystic carcinoma. After chemotherapy and radiotherapy, the tumor volume was reduced significantly (p < 0.0001). En bloc resection of the lacrimal sac malignancy was performed in all patients with concurrent partial ethmoidectomy in 8 patients and medial maxillectomy in 5 patients. One patient (5.6%) suffered from adenoid cystic carcinoma died of metastatic disease. Two patients (11.1%) with local recurrence received reoperation, and 1 patient (5.6%) with pulmonary metastasis received gamma knife radiosurgery. These patients are alive with no evidence of tumor. Other patients are alive without evidence of disease at last follow up. No patient had new onset of lymph node enlargement during and after the treatment.
CONCLUSIONS: The staged procedure is a promising method for the treatment of primary lacrimal sac epithelial malignancy with no postoperative lymph node metastasis.

PMID: 30204637 [PubMed - as supplied by publisher]

Immunohistochemical study of the expression of human chorionic gonadotropin-β in salivary gland tumors.

Fetched: September 12th, 2018, 5:00am GMT

Immunohistochemical study of the expression of human chorionic gonadotropin-β in salivary gland tumors.

J Cancer Res Ther. 2018 Jul-Sep;14(5):952-956

Authors: Meda S, Reginald BA, Reddy BS

Abstract
Background and Objectives: Human chorionic gonadotropin-β (hCGβ) is a hormone glycoprotein usually secreted by trophoblastic cells in early pregnancy and helps in growth and development of the embryo. While many trophoblastic and nontrophoblastic malignancies express elevated levels of hCGβ in serum, increased immunohistochemical reactivity has also been reported in malignant and aggressive tumors, thus serving as a marker. As limited studies exist on tumors of the oral- and para-oral region, it prompted us to observe the immunohistochemical expression of hCGβ in salivary gland tumors.
Materials and Methods: A total of 21 cases of salivary gland tumors - 16 cases of mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and five cases of pleomorphic adenoma - were included in the study. The sections were subjected to immunohistochemical procedures using hCGβ antigen. The degree of intensity and distribution of hCGβ immunostaining was assessed.
Results: One case of each (12.5%) MEC and ACC showed positive staining, and no staining was observed in the pleomorphic adenoma.
Conclusion: The presence of hCGβ positive tumor cells appears to potentially reflect the aggressive behavior of MEC and ACC.

PMID: 30197330 [PubMed - in process]

Disparities in Postoperative Therapy for Salivary Gland Adenoid Cystic Carcinomas.

Fetched: September 10th, 2018, 5:00am GMT

Disparities in Postoperative Therapy for Salivary Gland Adenoid Cystic Carcinomas.

Laryngoscope. 2018 Sep 08;:

Authors: Cassidy RJ, Switchenko JM, El-Deiry MW, Belcher RH, Zhong J, Steuer CE, Saba NF, McDonald MW, Yu DS, Gillespie TW, Beitler JJ

Abstract
OBJECTIVES: The patterns of care for salivary gland adenoid cystic carcinomas (ACC) are unknown. We sought to assess predictors of receiving postoperative radiation and/or chemotherapy for patients with nonmetastatic, definitively resected ACC, as well as report unexpected nodal disease.
METHODS: The National Cancer Data Base was queried for definitively resected nonmetastatic ACC from 2004 to 2014. Logistic regression, Kaplan-Meier, and Cox proportional-hazard models were utilized. Propensity-score matched analysis was employed to reduce confounding variables.
RESULTS: A total of 3,136 patients met entry criteria: 2,252 (71.8%) received postoperative radiation, with 223 (7.4%) also receiving concurrent chemotherapy. Median follow-up was 4.87 years. In clinically lymph node negative (cN0) patients, 7.4% had pathologically positive lymph nodes (pN) + after elective neck dissection. Patients who lived closer to their treatment facility and had positive margins were more likely to receive postoperative radiation. Black patients and uninsured patients were less likely to receive radiation. Older age, male sex, advancing stage, and positive surgical margins were associated with worse overall survival (OS). With limited follow-up, receipt of radiation or chemotherapy was not associated with OS.
CONCLUSION: Postoperative radiation was frequently given for resected ACC, with a minority receiving chemotherapy. Black patients and uninsured patients were less likely to receive radiation. Postoperative radiation and/or chemotherapy had no association with OS but were given in greater frequency in more advanced disease, and our series is limited by short follow-up. The disparity findings for this rare disease need to be addressed in future studies.
LEVEL OF EVIDENCE: 2c. Laryngoscope, 2018.

PMID: 30194768 [PubMed - as supplied by publisher]

Positive surgical margins in parotid malignancies: Institutional variation and survival association.

Fetched: September 10th, 2018, 5:00am GMT

Positive surgical margins in parotid malignancies: Institutional variation and survival association.

Laryngoscope. 2018 Sep 07;:

Authors: Morse E, Fujiwara RJT, Judson B, Prasad ML, Mehra S

Abstract
OBJECTIVES/HYPOTHESIS: To establish benchmarks for positive margin incidence in parotid cancers, associate positive margin status with patient, tumor, and institutional factors and overall survival, and characterize institutional variation in positive margin incidence.
STUDY DESIGN: Retrospective database analysis.
METHODS: We identified patients surgically treated for a parotid malignancy 2004 to 2013 in the National Cancer Database. We associated positive margins with patient, tumor, and treatment factors by multivariable logistic regression and with overall survival by Cox proportional hazards regression. We characterized institutional variation in positive margin rates by facility type and volume.
RESULTS: A total of 5,639 patients were identified. The overall positive margin rate was 31%. By institution, positive margin rates varied from 0% to 100%, with a median rate of 31% (interquartile range = 18%-43%). Adenoid cystic carcinoma was associated with increased, and low-grade mucoepidermoid carcinoma with decreased, odds of positive margins, (odds ratio [OR] = 1.91 [95% confidence interval {CI}: 1.54-2.38], P < .001 and OR = 0.68 [95% CI: 0.53-0.87], P = .002, respectively). Treatment at academic or high-volume facilities was associated with decreased odds of positive margins (OR = 0.79 [95% CI: 0.68-0.91], P = .001 and OR = 0.76 [95% CI: 0.63-0.91], P = .004). Positive surgical margins were associated with decreased overall survival (62% vs. 79% 5-year overall survival, hazard ratio [HR] = 1.34 [95% CI: 1.20-1.49], P < .001). Upon stratification by histology, this association was maintained for high-grade, but not low-grade, mucoepidermoid carcinoma (52% vs. 74%, HR = 1.56 [95% CI: 1.31-1.86], P < .001 and 89% versus 91%, HR = 1.05 [95% CI: 0.60-1.83], P = .874, respectively).
CONCLUSIONS: Tumor and institutional factors are associated with positive surgical margins. Positive margin rates vary substantially between facilities and are less likely at academic and high-volume facilities. Positive surgical margins are associated with decreased overall survival and could be considered quality indicators in parotid malignancies.
LEVEL OF EVIDENCE: 2c Laryngoscope, 2018.

PMID: 30194762 [PubMed - as supplied by publisher]

Permalink for 'Definitive Carbon-Ion Radiation Therapy for Locally Advanced Sinonasal Malignant Tumors: Subgroup Analysis of a Multicenter Study by the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS).'

Definitive Carbon-Ion Radiation Therapy for Locally Advanced Sinonasal Malignant Tumors: Subgroup Analysis of a Multicenter Study by the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS).

Fetched: September 9th, 2018, 5:00am GMT

Definitive Carbon-Ion Radiation Therapy for Locally Advanced Sinonasal Malignant Tumors: Subgroup Analysis of a Multicenter Study by the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS).

Int J Radiat Oncol Biol Phys. 2018 Oct 01;102(2):353-361

Authors: Koto M, Demizu Y, Saitoh JI, Suefuji H, Tsuji H, Okimoto T, Ohno T, Shioyama Y, Ikawa H, Nemoto K, Nakano T, Kamada T, Japan Carbon-Ion Radiation Oncology Study Group

Abstract
PURPOSE: To evaluate the safety and efficacy of carbon-ion radiation therapy (C-ion RT) for locally advanced sinonasal malignant tumors in a multicenter retrospective study (J-CROS 1402 HN).
METHODS AND MATERIALS: Clinical data were collected for patients who had sinonasal malignant tumors of stage N0-1M0 and received C-ion RT at 4 institutions in Japan between November 2003 and December 2014. Of the 458 patients, 393 had naïve tumors and 65 had recurrent tumors. The tumors were located in the nasal cavity (n = 263), maxillary sinus (n = 109), ethmoid sinus (n = 71), and other locations (n = 15). The histologic types were mucosal melanoma (n = 221, 48%), adenoid cystic carcinoma (n = 122, 27%), squamous cell carcinoma (n = 31, 7%), olfactory neuroblastoma (n = 30, 7%), adenocarcinoma (n = 21, 5%), and other types (n = 33, 7%). Of the 458 patients, 300 (66%) had T4 tumors. All patients received definitive C-ion RT.
RESULTS: The median follow-up period was 25.2 months for all patients (range, 1.4-132.3 months). The 2-year overall survival and local control rates were 79.6% and 84.1%, respectively. As analyzed according to histology, the 2-year overall survival rate was 68.0% for mucosal melanoma, 96.8% for adenoid cystic carcinoma, 70.0% for squamous cell carcinoma, 96.7% for olfactory neuroblastoma, and 89.7% for adenocarcinoma. Regarding late toxicities, 17% of patients developed grade 3 and 4 toxicities, of which visual impairment was the most common.
CONCLUSION: The results of our multicenter study have demonstrated that C-ion RT can provide excellent clinical outcomes with acceptable late toxicities in patients who have locally advanced sinonasal malignant tumors.

PMID: 30191869 [PubMed - in process]

Surgical treatment results of parapharyngeal space tumors: a report of 22 cases.

Fetched: September 9th, 2018, 5:00am GMT

Surgical treatment results of parapharyngeal space tumors: a report of 22 cases.

Otolaryngol Pol. 2018 May 16;72(4):9-16

Authors: Rzepakowska A, Osuch-Wójcikiewicz E, Krupa Z, Durmaj A, Niemczyk K

Abstract
INTRODUCTION: Parapharyngeal space (PPS) is the anatomical area lateral to the upper pharynx and clinically important due to PPS tumors. They account for less than 1% of head and neck neoplasms. Both benign and malignant neoplasms may arise there and typical for this localization is diversity of histological origin. Complete surgical excision is still the basis of treatment.
AIM OF THE STUDY: Evaluation of the results of surgical treatment of PPS tumors in the Department of Otolaryngology at the Medical University over the period 2015-2017.
MATERIAL AND METHODS: A retrospective analysis of medical records including complaints, physical examination, results of imaging studies, surgical approach, postoperative complication and histopathological results in 22 patients with a diagnosis of a PPS tumors.
RESULTS: The most frequent complaints reported by the patients were: discomfort in the throat, dysphagia, hearing disorders and a palpable tumor on the neck. Asymptomatic course of the disease was demonstrated in 4 cases. All patients were treated surgically: 2 with transoral approach, 9 with transparotid-transcervical approach, 11 with transcervical approach. In most cases the tumor was removed radically. In 2 patients intracapsular tumor resection was performed. Based on histopathological examination the benign lesions dominated (18/22). In 4 cases malignant neoplasms were diagnosed: carcinoma ex pleomorphic adenoma, adenoid cystic carcinoma and two cases of squamous cell carcinoma. The most common origin of PPS tumors was deep lobe of parotid gland and for this group 11 patients had diagnosis of pleomorphic adenoma. Other diagnosis included: paraganglioma, neurofibroma, hemangioma, lymphangioma and rhabdomyoma. Postoperative complications occurred in 9 patients and presented as hoarseness and dysphagia due to paresis of the lower group of cranial nerves (IX, X, XII). Significant intraoperative bleeding during surgery occurred in 2 cases and ligation of the external carotid artery was necessary.
CONCLUSION: Due to the anatomical topography of PPS and its content with the essential vessels and the lower group of cranial nerves, the surgical treatment of pathology of this area is still a challenge for head and neck surgeons. The decrease of voice quality and impaired speech and swallowing should always be considered as complications post the surgical resection in PPS.

PMID: 30190441 [PubMed - in process]

Adenoid cystic carcinoma of the breast: Experience at a tertiary care centre of Northern India.

Fetched: September 8th, 2018, 5:00am GMT

Adenoid cystic carcinoma of the breast: Experience at a tertiary care centre of Northern India.

Int J Surg Case Rep. 2018 Aug 31;51:204-209

Authors: Bhutani N, Kajal P, Singla S

Abstract
INTRODUCTION: Adenoid cystic carcinoma of the breast (breast-ACC) is a rare tumor with a favorable prognosis, despite its triple-negative status and special type of basal-like tumor for which scant population-based descriptive data exist. We sought to provide new population-based information on breast-ACC in India. Due to the paucity of the number of cases, the natural history of the disease is not fully understood. This study was undertaken to examine the clinico-pathological characteristics of the disease and to evaluate the outcome of surgical intervention in a tertiary referral care centre.
MATERIALS AND METHODS: A retrospective analysis of all patients diagnosed and treated for ACC Breast in our hospital over the past 10 years was carried out (2005-2015). A database of the characteristics of these patients was developed. In all, 14 patients were identified. The investigations performed included routine blood investigations, chest X-ray, bone scan and either an ultrasound or a CT scan.
RESULTS: During the time period of 10 years, of 2347 with breast malignancy admitted to our department, only 14 were diagnosed as having ACC (3.15%). All patients were women (100%). The patients had a median age of 60.7 years (range 37-81). The most common symptom was lump in the breast. Two patients (14.2%) presented with nipple and skin retraction and two patients (14.2%) were asymptomatic with the diagnosis made by an incidental finding on routine examination. The CT and/or magnetic resonance imaging (MRI) showed the typical features of carcinoma breast. All the 14 patients were taken up for surgery. Nine patients underwent Modified radical mastectomy and five patients underwent Breast conservation surgery. Axillary lymph node dissection was carried out in seven patients and sentinel lymph node biopsy in the remaining. Tumor cells had a characteristic histologic pattern of ACC of the breast. Perineural invasion was present in six cases.
DISCUSSION: ACC of the breast is a very rare malignancy, accounting for less than 0.1% of all breast neoplasms. It affects the left and right breasts equally and tumors arise irrespective of the breast quadrants. However, in about 50 percent of patients, lesions are found in subareolar region. Pain or tenderness described in the minority of cases has not been correlated with histologically-confirmed perineural invasion. ACC is categorized as a basal-like subtype of breast carcinoma. Most cases are macroscopically well-circumscribed. Occasionally, pink, tan, or gray microcysts are evident. A tumor typically consists of a dual-cell population of luminal and myoepithelial-basal cells which may be arranged in one or more of three architectural patterns: tubular-trabecular, cribriform, and solid-basaloid. There is no consensus on the optimal management for patients with ACC of the breast. Based on its indolent clinical course and favorable outcome, ACC of the breast is generally cured by breast-conserving surgery, such as wide excision or quadrantectomy with or without radiotherapy.
CONCLUSION: Breast-ACC among women is characterized by ER-negative/PR-negative expression, rare regional lymph node involvement, a favorable prognosis with excellent survival, and absence of associated cancers. These findings reinforce the importance of tailored treatments for breast-ACC and the apparent heterogeneity of basal-like breast cancers.

PMID: 30189404 [PubMed - as supplied by publisher]

[Adenoid cystic carcinoma cells produce exosomes that promote tumor cell proliferation].

Fetched: September 8th, 2018, 5:00am GMT

[Adenoid cystic carcinoma cells produce exosomes that promote tumor cell proliferation].

Nan Fang Yi Ke Da Xue Xue Bao. 2018 Jul 30;38(8):1008-1013

Authors: Liu X, Wang F, Hou J, Zhang L, Chen Z, Yin X

Abstract
OBJECTIVE: To observe the effect of exosomes released by adenoid cystic carcinoma (ACC) cell line SACC-83 on the proliferation of ACC cells.
METHODS: Exosomes were isolated from SACC-83 cell culture supernatants using total exosome isolation reagents. The whole-mount exosomes were characterized using transmission electron microscope and Western blotting. The exosomes were labeled with green fluorescent dye PKH67 and co-cultured with SACC-83 cells for 48 h, followed by staining with Alexa Fluor 594 phalloidin and DAPI to observe exosome uptake by the cells using laser scanning confocal microscopy (LSCM). The cell proliferation was assessed using MTT assay and wound healing assay, and the expressions of ERK and P-ERK in the co-cultured SACC-83 cells were detected using Western blotting.
RESULTS: The exosomes isolated from SACC-83 cells showed a size range of 30-100 nm and expressed the exosomal markers CD9, CD63 and TSG101. LSCM showed exosome uptake by SACC-83 cells, which exhibited accelerated proliferation and significantly enhanced P-ERK expression (P < 0.05) without significant changes in ERK expression.
CONCLUSIONS: SACC-83 cells produce exosomes that promote the tumor cell proliferation and enhances the cellular expression of P-ERK, suggesting a potential role of MAPK/ERK pathway activation in exosome-mediated acceleration of ACC cell proliferation.

PMID: 30187874 [PubMed - in process]

EGFR-Variant Adenoid Cystic Carcinoma of the Lung.

Fetched: September 2nd, 2018, 5:00am GMT

EGFR-Variant Adenoid Cystic Carcinoma of the Lung.

J Thorac Oncol. 2018 Sep;13(9):e178-e181

Authors: Mendes MA, Barroso A, Campainha S

PMID: 30166019 [PubMed - in process]

Immediate tracheal reconstruction with forearm flap and bone graft.

Fetched: September 1st, 2018, 5:00am GMT

Immediate tracheal reconstruction with forearm flap and bone graft.

Microsurgery. 2018 Aug 29;:

Authors: Kubo T, Kurita T, Tashima H, Suzuki M, Uemura H, Fujii T, Seike S, Inohara H, Hosokawa K

Abstract
BACKGROUND: "Window" resection of the trachea is sometimes performed to remove tumors invading the trachea. Here, we present a novel reconstructive procedure to this end.
METHODS: Eleven patients (mean age, 64 years; range, 46-80 years) were included. Primary diagnoses included thyroid cancer and adenoid cystic carcinoma of the trachea. All defects were partial and located in the neck (mean width and length, 3/5 circle and 7.5 rings; range, 1/2-2/3 circle and 5-9 rings). Immediate 2-stage reconstruction was performed using a forearm flap and free bone graft. The bone graft was utilized as a supportive skeleton. A tracheostoma was left open for several months following the initial surgery, and then closed.
RESULTS: The mean flap size was 6.1 × 9.7 cm (range, 6-7 × 7-16 cm). Mean number of grafted bone strips and length were 1.6 (range, 1-3) and 6.1 cm (range, 4.5-7 cm). All flaps survived. Five patients developed complications in the neck, including surgical site infections (SSIs), recurrent nerve palsy, and lymphorrhea. Four patients developed donor site complications, including clavicular fracture and SSIs. Mean postoperative follow-up lasted 85 months (range, 11-149 months). Normal speech was restored in 9 patients. Stoma closure was abandoned in 2 patients, because 1 patient showed vocal cord fixation with advanced age and the other showed bone graft loss following SSI.
CONCLUSIONS: Creating a tracheostoma during the first operation prevents postoperative airway compromise. Our bone graft placement easily achieves tracheal rigidity. This procedure is simple and safe for tracheal window defect repair.

PMID: 30159916 [PubMed - as supplied by publisher]

Immunohistochemical study of salivary gland tumors in a tertiary institution in South-South Region of Nigeria.

Fetched: September 1st, 2018, 5:00am GMT

Immunohistochemical study of salivary gland tumors in a tertiary institution in South-South Region of Nigeria.

J Oral Maxillofac Pathol. 2018 May-Aug;22(2):163-167

Authors: Omitola OG, Iyogun CA

Abstract
Aim: The aim of this study was to see the usefulness of immunohistochemistry in diagnosing salivary gland tumors found in a tertiary health institution.
Materials and Methods: Twenty-six formalin-fixed paraffin embedded salivary gland tumors were accessioned, and 2 μm were sectioned and processed using Streptavidin-Biotin immunoperoxidase method.
Results: Adenoid cystic carcinoma (ADCC) was positive to alpha-smooth muscle actin (α-SMA) while mucoepidermoid carcinoma (MEC), polymorphous low-grade adenocarcinoma (PLGA), squamous cell carcinoma (SCC) and oncocytic carcinoma (OCC) were all negative to it. MEC, PLGA, ADCC and the only pleomorphic adenoma (PA) were positive to Ki-67 while both SCC and OCC were negative to it. All the tumors except PA were positive to p63.
Conclusion: It appears that α-SMA may be used to distinguish ADCC from MEC and PLGA, but Ki-67 cannot be used for this purpose. Furthermore, p63 cannot help in the diagnosis of ADCC, MEC or PLGA. It was concluded that immunochemistry can be used as adjunct to routine H and E stain in the diagnosis of the various salivary gland tumors.

PMID: 30158766 [PubMed]

[Pediatric salivary gland tumors and tumor-like lesions].

Fetched: August 31st, 2018, 5:00am GMT

[Pediatric salivary gland tumors and tumor-like lesions].

Pathologe. 2017 Jul;38(4):294-302

Authors: Agaimy A, Iro H, Zenk J

PMID: 28597093 [PubMed - indexed for MEDLINE]

Lacrimal gland tumors in Turkey: types, frequency, and outcomes.

Fetched: August 26th, 2018, 5:00am GMT

Lacrimal gland tumors in Turkey: types, frequency, and outcomes.

Int J Ophthalmol. 2018;11(8):1296-1302

Authors: Yeşiltaş YS, Gündüz AK, Erden E, Shields CL

Abstract
AIM: To evaluate the clinical, radiological, and treatment features of lacrimal gland tumors.
METHODS: Retrospective review of 99 eyes of 92 patients with lacrimal gland tumors diagnosed and managed in a single institution between January 1999 and March 2017. Clinical and radiological features, histopathology, treatment methods, and prognosis were evaluated.
RESULTS: The mean patient age was 40.3 (range: 7-80)y. The diagnosis was made histopathologically in 91 (91.9%) tumors and on a clinical and radiological basis in 8 (8.1%) tumors. Final diagnoses included idiopathic orbital inflammation (pseudotumor) in 46 (46.5%) lesions, pleomorphic adenoma in 14 (14.1%), adenoid cystic carcinoma in 12 (12.1%), granulomatous inflammation in 10 (10.1%), lymphoma in 5 (5.0%), benign reactive lymphoid hyperplasia in 3 (3.0%), dacryops in 3 (3.0%), carcinoma ex pleomorphic adenoma in 2 (2.0%), adenocarcinoma in 1 (1.0%), dermoid cyst in 1 (1.0%), cavernous hemangioma in 1 (1.0%), and leukemic infiltration in 1 (1.0%). Non-epithelial tumors comprised 64.6% (n=64) of all lacrimal gland tumors, epithelial tumors 32.3% (n=32), dermoid cyst 1% (n=1), cavernous hemangioma 1% (n=1), and leukemic infiltration 1% (n=1). There were in total 78 (78.8%) benign and 21 (21.2%) malignant tumors.
CONCLUSION: Overall, 65% of lacrimal gland tumors were of non-epithelial origin and 32% of epithelial origin. By histopathology and clinical evaluation, 79% of lacrimal gland tumors were benign. The most common lacrimal gland tumors include idiopathic orbital inflammation (46.5%), epithelial (32.3%), and lymphoproliferative (8.1%) lesions.

PMID: 30140632 [PubMed]

Cranio-orbital Resection Does Not Appear to Improve Survival of Patients With Lacrimal Gland Carcinoma.

Fetched: August 23rd, 2018, 5:00am GMT

Cranio-orbital Resection Does Not Appear to Improve Survival of Patients With Lacrimal Gland Carcinoma.

Ophthalmic Plast Reconstr Surg. 2018 Aug 20;:

Authors: Rose GE, Gore SK, Plowman NP

Abstract
PURPOSE: To ascertain long-term outcome of treatment for primary epithelial malignancies of the lacrimal gland and compare outcomes after cranio-orbital resection or after macroscopic tumor resection with radiotherapy.
METHODS: Comparative case series of 79 patients (49 male; 62%) treated for primary epithelial malignancies of the lacrimal gland at Moorfields Eye Hospital between 1972 and 2014. Patients were identified from clinical and pathological databases and, where available, the clinical, pathological, and imaging records reviewed. The primary outcome measures were overall survival after diagnosis, disease-free survival, and final visual acuity for patients having cranio-orbital resection (exenteration plus local bone removal), compared with macroscopic tumor resection plus radiotherapy.
RESULTS: The mean age at presentation was 48 years (median: 50 years; range: 13-84 years), with 53 (67%) having adenoid cystic carcinoma, 15 (19%), primary adenocarcinoma, and 11 (14%) carcinoma ex-pleomorphic adenoma (malignant mixed tumor). The overall survival probability of the cohort (79 patients) was 0.59 at 5 years and 0.52 at 10 years, with 36/79 (46%) patients suffering tumor-related deaths; 14 patients died from other causes, and 4 patients were lost to follow up after the minimum follow-up period. The probability of disease-free survival at 5 years for patients with adenoid cystic carcinoma, adenocarcinoma, and malignant mixed tumor was 0.52, 0.4, and 0.64, respectively, with the comparable figures at 10 years being 0.44, 0.40, and 0.64. Most importantly, the 9 patients undergoing cranio-orbital resection and the 44 having solely macroscopic tumor resection plus radiotherapy had similar overall survival (p = 0.59) and disease-free survival (p = 0.89). Subgroup analysis of the 2 treatment modalities for patients with adenoid cystic carcinoma (8 cranio-orbital resection and 32 debulking and radiotherapy) demonstrated similar results for disease-free survival (p = 0.87). Likewise, there were no significant differences between rates of recurrences between the 2 different treatments. For the 50 patients who had eye-preserving surgery and long-term visual acuity data, the final acuity was better or equal to 0.6 logMAR (6/24 Snellen) in 25 (50%).
DISCUSSION: There is no difference in either survival or tumor recurrence for lacrimal gland carcinoma treated with cranio-orbital resection, or eye-preserving tumor excision and radiotherapy. The authors, therefore, continue to advocate local resection and radiotherapy for almost all patients with primary epithelial malignancies of the lacrimal gland-this treatment having lower morbidity, causing less disfigurement, and, importantly, preserving useful vision in most patients.

PMID: 30130333 [PubMed - as supplied by publisher]

Adenoid cystic carcinoma of the larynx in a 70-year-old patient: A case report.

Fetched: August 23rd, 2018, 5:00am GMT

Adenoid cystic carcinoma of the larynx in a 70-year-old patient: A case report.

Oncol Lett. 2018 Sep;16(3):2783-2788

Authors: Ricciardiello F, Addeo R, Di Lullo AM, Abate T, Mazzone S, Oliva F, Motta G, Caraglia M, Mesolella M

Abstract
Adenoid cystic carcinoma (ACC) is a relatively rare tumor that accounts for <1% of all head and neck malignancies. Laryngeal localization of ACC, which is most commonly hypoglottic, is relatively rare, occurring in 0.07-0.25% of all laryngeal tumors. ACC is characterized as a slow-growing tumor with a high recurrence rate, which often causes dyspnea and hoarseness. ACC exhibits a propensity for perineural invasion and thus, patients may experience pain as a late symptom of the disease. Distant metastasis occurs in 35-50% of cases and the lungs are the most common site of metastasis. Tumors are usually diagnosed by physical examination with fiberoscopy and computed tomography of the neck and chest, due to the high rate of lung metastases. The standard therapy for ACC is surgery followed by radiotherapy. In this study, a 70-year-old patient presented with laryngeal ACC, who underwent total laryngectomy with bilateral neck dissection and adjuvant radiotherapy, is presented. Follow-up examination performed 2 years after surgery revealed no evidence of locoregional recurrence or distant metastases. Previously published literature regarding ACC of the larynx was also reviewed.

PMID: 30127863 [PubMed]

Adenoid cystic carcinoma with myoepithelial predominance affecting maxilla and maxillary sinus.

Fetched: August 22nd, 2018, 5:00am GMT

Adenoid cystic carcinoma with myoepithelial predominance affecting maxilla and maxillary sinus.

J Stomatol Oral Maxillofac Surg. 2018 Aug 17;:

Authors: de Aquino SN, Verner FS, Cabral RÁ, Rios CHN, de Almeida OP, Sánchez-Romero C

Abstract
Adenoid cystic carcinoma (ACC) represents less than 10% of all salivary gland tumors, rarely occurring centrally in the jaws. Herein we describe the case of a 36-year-old female patient presenting a painless swelling in the right maxilla, resulting in marked facial asymmetry. Intraorally it was observed a swelling covered by an erythematous and irregular-surfaced mucosa, affecting the gingiva and crossing the midline of the hard palate. Imaging studies showed a mixed radiolucent-radiopaque lesion with ill-defined borders, involving the right side of the maxilla and the maxillary sinus. Incisional biopsy revealed basophilic cribriform tumoral islands and solid sheets of neoplastic cells invading bone trabeculae. Most of the tumoral cells presented myoepithelial characteristics, while few true luminal/epithelial cells were observed. To illustrate the epithelial-myoepithelial pattern, immunohistochemical reactions were performed, as well as double immunohistochemical staining. The diagnosis was intraosseous ACC, which features were discussed as well as the potential differential diagnosis.

PMID: 30125736 [PubMed - as supplied by publisher]

Evidence Based Tailored Parotidectomy in Treating External Auditory Canal Carcinoma.

Fetched: August 17th, 2018, 5:00am GMT

Evidence Based Tailored Parotidectomy in Treating External Auditory Canal Carcinoma.

Sci Rep. 2018 Aug 14;8(1):12112

Authors: Lee JM, Joo JW, Kim SH, Choi JY, Moon IS

Abstract
Carcinoma of the external auditory canal (EAC) is a rare tumor and little information is available regarding parotid gland in surgically treating EAC carcinomas. This study aimed to investigate the mode of parotid involvement in EAC carcinoma through staging and histopathological analysis, and to establish surgical guidelines for the parotid gland management when there is no clinical evidence of parotid involvement. Sixty-five patients with EAC carcinoma who underwent temporal bone resection and any type of parotidectomy simultaneously were retrospectively reviewed. The rate of direct parotid invasion and parotid nodal involvement was analyzed according to the stage and histopathological findings. Among the 65 patients, 39 were confirmed to have squamous cell carcinoma (SCC) and 26 were confirmed to have adenoid cystic carcinoma (ACC). Direct parotid invasion occurred in 7 of 39 patients with SCC, only in the advanced stages, and in 15 of 26 patients with ACC, regardless of stage. Metastasis to the parotid node was noted in 6 patients with advanced-stage SCC, whereas no patient with ACC showed parotid nodal metastasis. For adequate tumor control with low risk of surgical complications, evidence based tailored parotidectomy should be applied. With no evidence of parotid involvement, an elective parotidectomy can be excluded in early SCC, whereas a total parotidectomy is recommended for advanced SCC. In ACC, basal resection of the parotid gland rather than a superficial or total parotidectomy should be performed at all disease stages.

PMID: 30108249 [PubMed - in process]

Liver metastasis from adenoid cystic carcinoma: imaging and histologic features.

Fetched: August 17th, 2018, 5:00am GMT

Liver metastasis from adenoid cystic carcinoma: imaging and histologic features.

Curr Probl Cancer. 2018 Jul 22;:

Authors: Picchia S, Riddell A, Terlizzo M, Bali MA

Abstract
Adenoid cystic carcinoma is a rare tumour. The reported incidence of isolated metastases to the liver is rare but possible and it seems to be more likely in case of perineural invasion.

PMID: 30107895 [PubMed - as supplied by publisher]

Impact of tumour profiling on clinical trials in salivary gland cancer.

Fetched: August 15th, 2018, 5:00am GMT

Impact of tumour profiling on clinical trials in salivary gland cancer.

Clin Otolaryngol. 2018 Aug 13;:

Authors: Rack S, Rahman R, Carter L, McKay C, Metcalf R

Abstract
Salivary gland cancer is a rare disease comprising multiple biologically diverse disease entities. Clinical trials have had relatively less impact on clinical practice in comparison with other cancer types. Here we describe clinical trials recruiting in salivary gland cancer and 'basket studies' incorporating molecular analysis using next generation sequencing (NGS) to stratify patients for molecularly targeted therapies. A systematic review of clinicaltrials. gov, PUBMED and ASCO, ESMO and AACR meeting abstracts was performed to identify clinical trials recruiting either salivary gland cancer cohorts or 'basket studies' which would be suitable for salivary gland cancer patients. Three of twenty trials recruiting salivary gland cancer patients were in the adjuvant setting. Of the remaining trials, 9/17 included molecular stratification for matched therapy. These included 3 large basket studies of matched therapy in molecular sub-groups (MATCH, TAPUR, and CAPTUR). Next generation sequencing (NGS) has utility to identify potentially actionable genetic alterations in salivary gland cancer and basket studies will identify signals of activity in these rare sub-groups and will generate novel biological hypotheses. However, to fully understand the functional significance of the molecular alterations within the context of salivary gland cancer, further laboratory and translational studies are required. This article is protected by copyright. All rights reserved.

PMID: 30102009 [PubMed - as supplied by publisher]

Permalink for 'Pure small-cell carcinoma of the prostate presenting with increasing prostate-specific antigen levels: A case report and review of the literature.'

Pure small-cell carcinoma of the prostate presenting with increasing prostate-specific antigen levels: A case report and review of the literature.

Fetched: August 15th, 2018, 5:00am GMT

Pure small-cell carcinoma of the prostate presenting with increasing prostate-specific antigen levels: A case report and review of the literature.

Mol Clin Oncol. 2018 Aug;9(2):197-200

Authors: Hu J, He T, Jin L, Li Y, Zhao Y, Li W, Wei B, Mao XM, Lai YQ, Ni LC

Abstract
The incidence of prostatic cancer (PCa) has increased significantly, and the measurement of prostate-specific antigen (PSA) is an effective screening tool for its diagnosis. PCa includes a number of specific clinicopathological types, including squamous cell, urothelial, adenoid cystic and small-cell carcinoma, among which small-cell carcinoma of the prostate (SCCP) is extremely rare, accounting for <0.5% of all PCa cases. SCCP is very aggressive and the majority of the cases have a poor prognosis, with a mean survival of ~5 months; it also exhibits specific clinicopathological characteristics and may be divided into two subtypes, namely pure and mixed SCCP. According to the previous literature on PubMed, pure SCCP is not associated with an increase in serum PSA levels. However, the rare case presented herein exhibited an increasingly abnormal serum PSA level. The patient was aged 66 years and had a PSA level of 56.78 ng/ml (normal, <4 ng/ml); he was diagnosed with pure SCCP, underwent radical prostatectomy and has remained disease-free during the follow-up. Similar cases previously published on PubMed were also reviewed, and considerations of survival status and treatment options were analyzed.

PMID: 30101021 [PubMed]

Comprehensive and in-depth analysis of microRNA and mRNA expression profile in salivary adenoid cystic carcinoma.

Fetched: August 14th, 2018, 5:00am GMT

Comprehensive and in-depth analysis of microRNA and mRNA expression profile in salivary adenoid cystic carcinoma.

Gene. 2018 Aug 08;:

Authors: Han N, Lu H, Zhang Z, Ruan M, Yang W, Zhang C

Abstract
OBJECTIVES: To conduct an integrated analysis of microRNA and mRNA expression profile and further discover vital molecules to uncover novel pathogenic mechanisms in salivary adenoid cystic carcinoma (SACC).
MATERIALS AND METHODS: MicroRNA and mRNA expression profiles were obtained from six paired primary SACC tumors and corresponding adjacent normal glands using high-throughput next-generation sequencing technology followed by an overall integrated bioinformatics analysis and subsequently molecular biology techniques validation.
RESULTS: Compared with adjacent noncancerous normal gland, 2107 significant differentially expressed mRNA were determined in SACC. Gene ontology and KEGG pathway analysis suggested that the differentially expressed genes were relevant to many significant biological implications. Venn diagram analysis of differentially expressed genes in different group identified 29 differentially expressed overlapping mRNA 40 differentially expressed microRNAs were also identified in SACC. Furthermore, integrated analysis of microRNA and mRNA expression profiles recognized a core microRNA-mRNA regulatory network and unmasked many novel genes including SCUBE3, CA6, hsa-miR-885-5p and other molecules which may play an essential role in the carcinogenesis of SACC. Also, QPCR and immunohistochemistry results reveal the high expression and distribution of SCUBE3 in SACC and dual luciferase reporter assay also preliminarily validated that SCUBE3 was a target of hsa-miR-885-5p.
CONCLUSION: Contemporary microRNA/mRNA analysis have uncovered many mRNAs and microRNAs worthy further exploration in SACC. These are bound to help us shed light on the overall genetic background of SACC and further elucidate the potential molecular mechanism of SACC.

PMID: 30098429 [PubMed - as supplied by publisher]

Permalink for 'A new approach to left sleeve pneumonectomy: complete VATS left pneumonectomy followed by right thoracotomy for carinal resection and reconstruction.'

A new approach to left sleeve pneumonectomy: complete VATS left pneumonectomy followed by right thoracotomy for carinal resection and reconstruction.

Fetched: August 14th, 2018, 5:00am GMT

A new approach to left sleeve pneumonectomy: complete VATS left pneumonectomy followed by right thoracotomy for carinal resection and reconstruction.

Surg Case Rep. 2018 Aug 10;4(1):91

Authors: Fujino T, Tanahashi M, Yukiue H, Suzuki E, Yoshii N, Shitara M, Kaminuma Y, Niwa H

Abstract
BACKGROUND: Left sleeve pneumonectomy is a challenging operation that requires individualized approaches. Here, we present a new minimally invasive combined thoracoscopic approach.
CASE PRESENTATION: A 61-year-old woman was diagnosed with tracheobronchial adenoid cystic carcinoma. The tumor originated from the left main stem bronchus, and tumor with carinal involvement was observed. We judged that complete resection would be possible via left sleeve pneumonectomy. However, because tumor involvement with the esophagus and descending aorta was suspected, evaluation of resectability in advance was necessary. After confirmation via examination thoracoscopy of no involvement with the surrounding organs, complete VATS left pneumonectomy was performed and followed by right thoracotomy for carinal resection and reconstruction.
CONCLUSIONS: When thoracoscopic surgery becomes mainstream, this minimally invasive combined thoracoscopic approach might be an optimal option for patients who require left sleeve pneumonectomy.

PMID: 30097740 [PubMed]

Permalink for 'Primary cutaneous adenoid cystic carcinoma mimicking dermal cylindroma: histology of the complete surgical excision as the key to diagnosis.'

Primary cutaneous adenoid cystic carcinoma mimicking dermal cylindroma: histology of the complete surgical excision as the key to diagnosis.

Fetched: August 12th, 2018, 5:00am GMT

Primary cutaneous adenoid cystic carcinoma mimicking dermal cylindroma: histology of the complete surgical excision as the key to diagnosis.

J Dtsch Dermatol Ges. 2018 Aug;16(8):1016-1018

Authors: Rütten A, Hegenbarth W, Kohl PK, Hillen U, Redler S

PMID: 30094921 [PubMed - in process]

Permalink for 'Tracheal segmental resection for tracheal cancer: comparison of cervical collar incision with median sternotomy and posterolateral incision.'

Tracheal segmental resection for tracheal cancer: comparison of cervical collar incision with median sternotomy and posterolateral incision.

Fetched: August 12th, 2018, 5:00am GMT

Tracheal segmental resection for tracheal cancer: comparison of cervical collar incision with median sternotomy and posterolateral incision.

J Surg Case Rep. 2018 Aug;2018(8):rjy201

Authors: Takanashi Y, Matsuura S, Neyatani H, Funai K

Abstract
We compare two surgical approaches for segmental tracheal resection for tracheal cancer: cervical collar incision with median sternotomy and right posterolateral incision. In case one, a 46-year-old woman presented with adenoid cystic carcinoma, measuring 4.5 cm longitudinally, located at the junction of the cervical and mediastinal trachea. Cervical collar incision with median sternotomy provided a good exposure of the entire trachea. Although a relatively long tracheal resection (5.0 cm) was required, sufficient mobilization of the entire trachea facilitated low-tension anastomosis. In case 2, a 39-year-old man presented with squamous cell carcinoma, measuring 1.8 cm longitudinally, located at the lower trachea 1.8 cm from the carina to the proximal side. Right posterolateral incision provided a good exposure of the lower trachea. Although the required tracheal resection was relatively short (3.0 cm), the anastomotic tension was high. The high anastomotic tension was likely attributed to the limited mobilization of the proximal trachea.

PMID: 30093998 [PubMed]

Restoring a Partial Maxillectomy Patient by an Implant-Supported Obturator on Two Implants: A Case Report.

Fetched: August 12th, 2018, 5:00am GMT

Restoring a Partial Maxillectomy Patient by an Implant-Supported Obturator on Two Implants: A Case Report.

J Dent (Tehran). 2018 May;15(3):187-192

Authors: Beyabanaki E, Alikhasi M

Abstract
This article describes the prosthetic treatment of a patient suffering from a hemimaxillary defect after surgical resection of an adenoid cystic carcinoma (ACC) in the palate. The patient had also received therapeutic irradiation. One year after radiotherapy, three implants were placed in the remaining maxillary bone without any bone augmentation. One of the implants failed during the osseointegration period. The implant replacing the failed one also failed during prosthetic procedures. The patient was unwilling to undergo another surgical episode, and the final prosthesis was completed on the two remaining implants.

PMID: 30090119 [PubMed]

Submandibular gland cancer: Specific features and treatment considerations.

Fetched: August 12th, 2018, 5:00am GMT

Submandibular gland cancer: Specific features and treatment considerations.

Head Neck. 2018 Jan;40(1):154-162

Authors: Aro K, Tarkkanen J, Saat R, Saarilahti K, Mäkitie A, Atula T

Abstract
BACKGROUND: In the absence of unified treatment protocol, we evaluated the management and outcomes of submandibular gland cancers in an unselected patient series.
METHODS: We included all patients with resected submandibular gland cancer treated at the Helsinki University Hospital from 2000 to 2010 with a 5-year minimum follow-up.
RESULTS: Twenty-five patients with cancer represented 30% of submandibular gland neoplasms, and most were adenoid cystic carcinomas (ACCs; 56%). At presentation, 3 patients showed clinical signs of probable malignancy. Of 22 neck dissection specimens, 5 patients (20%) had metastases with an occult metastasis rate of 4%. Cancer recurred in 11 patients (44%), of which 7 (28%) were only at a distant site. The 5-year disease-specific survival (DSS) and overall survival (OS) rates were 76%, and disease-free survival (DFS) was 68%.
CONCLUSION: Most tumors were ACCs differing from the histological pattern of parotid gland cancers. Occult metastases were rare. The rarity of submandibular gland cancer, its variable histological pattern, and varying biological behavior warrant centralized management.

PMID: 29083518 [PubMed - indexed for MEDLINE]

MicroRNAs expression pattern related to mast cell activation and angiogenesis in paraffin-embedded salivary gland tumors.

Fetched: August 9th, 2018, 5:00am GMT

MicroRNAs expression pattern related to mast cell activation and angiogenesis in paraffin-embedded salivary gland tumors.

Pathol Res Pract. 2017 Dec;213(12):1470-1476

Authors: Santos PRB, Coutinho-Camillo CM, Soares FA, Freitas VS, Vilas-Bôas DS, Xavier FCA, Rocha CAG, de Araújo IB, Dos Santos JN

Abstract
The aim of this study was evaluate the expression profile of microRNAs related to mast cells activation and angiogenesis in salivary glands tumors.
METHOD: We have analyzed the expression of miR-9, miR-16, miR-17, miR-132, miR-195 and miR-221 by real-time RT-PCR, in 11 adenoid cystic carcinomas, 9 mucoepidermoid carcinomas and 11 pleomorphic adenomas. Immunohistochemical investigation was performed to detect mast cells tryptase and CD-34 for microvessels biomarkers. miR-16, miR-17, miR-132, miR-195 and miR-221 showed a decreased expression, whereas miR-9 showed an increased expression in most cases compared to normal tissues. However, in all tumors studied only miR-9 showed a statistical significant negative correlation with microvessel density (p=0.001). It was observed a higher density of mast cells in mucoepidermoid carcinomas (10.55 cells/mm2) when compared to adenoid cystic carcinomas (6.27 cells/mm2) and between mucoepidermoid carcinomas and pleomorphic adenomas (5.97células/mm2). miR-17, miR-132, miR-195 and miR-221 seem to play an important role as tumor suppressor in salivary gland tumors. In addition, the significant correlation between mast cell and microvessel density contributes to the growth and pathogenesis of these tumors and they may become strong therapeutic targets in the future.

PMID: 29108921 [PubMed - indexed for MEDLINE]

Permalink for 'Strong SOX10 expression in HPV-related multiphenotypic sinonasal carcinoma: report of six new cases validated by high-risk HPV mRNA in situ hybridization test.'

Strong SOX10 expression in HPV-related multiphenotypic sinonasal carcinoma: report of six new cases validated by high-risk HPV mRNA in situ hybridization test.

Fetched: August 4th, 2018, 5:00am GMT

Strong SOX10 expression in HPV-related multiphenotypic sinonasal carcinoma: report of six new cases validated by high-risk HPV mRNA in situ hybridization test.

Hum Pathol. 2018 Jul 30;:

Authors: Hsieh MS, Lee YH, Jin YT, Huang WC

Abstract
HPV-related multiphenotypic sinonasal carcinoma (HMSC) is associated with high-risk human papillomavirus (HR-HPV) infection. Using HR-HPV mRNA in situ hybridization (ISH), we reported six new HMSC cases and compared their histopathology with that of sinonasal adenoid cystic carcinoma (ACC). Using p16 immunohistochemistry (IHC) and HR-HPV ISH, we retrospectively identified six HMSC cases. All HMSC cases were positive for HR-HPV mRNA ISH and p16 IHC. Two HMSC cases had overlying atypical squamous epithelium and one also had invasive squamous cell carcinoma (SCC). All HMSC were SOX10-positive whereas the overlying atypical squamous epithelium and the SCC were SOX10-negative. One atypical HMSC-like case was also identified which was positive for HR-HPV mRNA ISH, HR-HPV DNA ISH, SOX10 IHC, but negative for p16 IHC. This study showed that HR-HPV mRNA ISH was a useful tool to diagnose HMSC and had stronger signals than HR-HPV DNA ISH. HR-HPV E6/E7 mRNA could be identified in the overlying atypical squamous epithelium as well as the invasive SCC. A combination of p16 and SOX10 IHC will be a useful screening panel for HMSC followed by confirmatory HR-HPV mRNA ISH test.

PMID: 30071233 [PubMed - as supplied by publisher]

Long-term Outcomes of Globe-Preserving Surgery with Proton Beam Radiation for Adenoid Cystic Carcinoma of the Lacrimal Gland.

Fetched: August 4th, 2018, 5:00am GMT

Long-term Outcomes of Globe-Preserving Surgery with Proton Beam Radiation for Adenoid Cystic Carcinoma of the Lacrimal Gland.

Am J Ophthalmol. 2018 Jul 30;:

Authors: Wolkow N, Jakobiec FA, Lee H, Sutula FC

Abstract
PURPOSE: To describe outcomes of globe-preserving surgery combined with high dose proton beam radiation (PBR) in treating primary adenoid cystic carcinoma (ACC) of the lacrimal gland.
DESIGN: Retrospective case series.
METHODS: Twenty-nine patients with primary ACC of the lacrimal gland were identified in the records of a single institution between 1990 and 2017. Patients with non-orbital primary tumor origins or with inadequate follow-ups were excluded. Eighteen patients met inclusion criteria. Clinical data, imaging studies, histopathology, treatment modality, local recurrences, visual outcomes, metastases and survivals were assessed. Disease-free survivals for the current patients were measured and compared to those of other studies.
RESULTS: The eighteen patients (14 females, 4 males) were followed for a median of 12.9 years (range 0.6 to 22.3 years) post treatment completion. Their median age was 40 years. Four were children (median age 12 years). All were treated with globe-preserving tumor resection and radiation (median dose of 72 Cobalt Grey Equivalents). Three adult patients died from metastatic disease (median of 4.2 years after treatment). Four had local recurrences. Useful vision (20/40 or better) was retained for a median 3 years (range 1 to 12.9 years). Radiation morbidity included brain injury, retinopathy, optic neuropathy, keratopathy and cataract. Overall and disease-free survivals were significantly better compared to historical treatments, but did not differ statistically from other modern approaches.
CONCLUSIONS: Globe-preserving surgery with PBR, although imperfect, has a favorable long-term survival compared to other modern modalities with a variable period of useful vision.

PMID: 30071211 [PubMed - as supplied by publisher]

Permalink for 'MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: a cohort study.'

MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: a cohort study.

Fetched: August 4th, 2018, 5:00am GMT

MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: a cohort study.

Virchows Arch. 2018 Aug 01;:

Authors: Andreasen S, Tan Q, Agander TK, Hansen TVO, Steiner P, Bjørndal K, Høgdall E, Larsen SR, Erentaite D, Olsen CH, Ulhøi BP, Heegaard S, Wessel I, Homøe P

Abstract
Adenoid cystic carcinoma (ACC) is among the most frequent malignancies of the salivary gland, and is notorious for its prolonged clinical course characterized by frequent recurrences often years after initial treatment. No molecular marker has been shown to have independent prognostic value in ACC, including characteristic gene fusions involving MYB, MYBL1, and NFIB. MicroRNA has been shown to be associated with clinical outcome in numerous malignancies, including one study of ACC, warranting further validation of this class of markers in this disease. Here, we investigate the prognostic value of microRNA in two ACC cohorts: a training cohort (n = 64) and a validation cohort (n = 120) with microarray and qPCR. In the training cohort, multivariate analysis of microarray data found high expression of hsa-miR-6835-3p to be associated with reduced recurrence-free survival (RFS) (p = 0.016). Measuring the highest ranking microRNAs identified in survival analysis in the same cohort, qPCR identified high expression of hsa-miR-4676 to be associated with reduced overall survival (OS) and high expression of hsa-mir-1180 to be associated with improved RFS. This was not confirmed in the validation cohort, in which qPCR identified high expression of hsa-mir-21, hsa-mir-181a-2, and hsa-mir-152 to be associated with reduced OS and high expression of hsa-miR-374c to be associated with improved RFS. Interestingly, two distinct subsets of ACC separated in microRNA expression irrespective of gene fusion status, but without significant difference in outcome. Collectively, qPCR identified several microRNAs associated with OS and RFS, and different subsets of ACC separated according to microRNA expression, suggestive of ACC being a heterogeneous group of malignancies in its microRNA profile.

PMID: 30069755 [PubMed - as supplied by publisher]

Rare breast metastasis from adenoid cystic carcinoma of the submandibular gland.

Fetched: August 4th, 2018, 5:00am GMT

Rare breast metastasis from adenoid cystic carcinoma of the submandibular gland.

BMJ Case Rep. 2018 Aug 01;2018:

Authors: Krucoff KB, Shammas RL, Stoecker M, Tolnitch LA

Abstract
Adenoid cystic carcinomas (ACCs) are rare malignant neoplasms of exocrine glands, most commonly found in salivary glands. This report describes a 67-year-old woman with metastatic ACC to the breast, only the third reported case of its kind. The salivary gland ACC was first diagnosed 5 years prior. Routine mammogram identified a Breast Imaging and Reporting Systems (BIRADS) 4 lesion. Core breast biopsy demonstrated findings consistent with metastatic ACC to the breast. The patient ultimately underwent local excision but suffered a recurrence of disease less than 2 months later despite chemotherapy. She passed away 15 months after excision due to complications associated with a small bowel obstruction and decompensated respiratory status from pulmonary metastases. While metastatic salivary ACC to the breast is rare, it is important to be able to distinguish metastatic salivary ACC to the breast from primary ACC of the breast as the treatment considerations for the two disease processes differ significantly.

PMID: 30068574 [PubMed - in process]

Permalink for 'Three-year results after radiotherapy for locally advanced sinonasal adenoid cystic carcinoma, using highly conformational radiotherapy techniques proton therapy and/or Tomotherapy.'

Three-year results after radiotherapy for locally advanced sinonasal adenoid cystic carcinoma, using highly conformational radiotherapy techniques proton therapy and/or Tomotherapy.

Fetched: August 3rd, 2018, 5:00am GMT

Three-year results after radiotherapy for locally advanced sinonasal adenoid cystic carcinoma, using highly conformational radiotherapy techniques proton therapy and/or Tomotherapy.

Cancer Radiother. 2018 Jul 28;:

Authors: Dautruche A, Bolle S, Feuvret L, Le Tourneau C, Jouffroy T, Goudjil F, Zefkili S, Nauraye C, Rodriguez J, Herman P, Calugaru V

Abstract
PURPOSE: We report the patient outcomes of a treatment combining proton therapy and Tomotherapy in sinonasal adenoid cystic carcinoma involving skull base.
MATERIALS AND METHODS: We included patients treated at Curie Institute, Paris, France, between March 2010 and February 2014 for an advanced adenoid cystic carcinoma involving skull base. Patients received Tomotherapy, proton therapy or both. We evaluated treatment toxicity (according to CTCAE V4), local control, distant metastasis-free survival and overall survival.
RESULTS: Thirteen patients were included, with a median follow-up of 34 months. Radiation therapy followed surgery for 77% of the patients and margins were positive in all those cases. Median dose was 73.8Gy. Local control, distant metastasis-free survival and overall survival at 3 years were respectively 60%, 48% and 60%. One-sided grade 3 hearing impairment occurred in 46% of the patients.
CONCLUSION: Combining high-dose proton therapy and Tomotherapy is effective and has moderate toxicity in the treatment of T4 sinonasal adenoid cystic carcinoma involving skull base.

PMID: 30064829 [PubMed - as supplied by publisher]

Mutational landscape and clonal diversity of pulmonary adenoid cystic carcinoma.

Fetched: August 3rd, 2018, 5:00am GMT

Mutational landscape and clonal diversity of pulmonary adenoid cystic carcinoma.

Cancer Biol Ther. 2018 Aug 01;:1-6

Authors: Li M, Zhao BR, Liu SQ, An J, Deng PB, Han-Zhang H, Ye JY, Mao XR, Chuai SK, Hu CP

Abstract
Pulmonary adenoid cystic carcinoma is a rare and indolent lung malignancy, characterized by a protracted but unpredictable growth behavior. Currently, the treatment of PACC relies on surgery and local radiotherapy. However, treatment options for advanced PACC patients are limited. A larger number of studies demonstrated that advanced PACC patients obtained limited benefit from chemotherapy. Moreover, only a few case reports revealed PACC patients were candidates for target therapy. Therefore, there is an urgent need to develop novel therapies. Due to its rareness, its mutational landscape remains largely elusive. In this study, we performed capture-based ultra-deep sequencing on multiregional surgical specimens obtained from 8 PACC patients using a panel consisting of 295 cancer-related genes. Our data revealed distinctive mutational spectrum of PACC, which differed from non-small cell lung cancer and adenoid cystic carcinomas originated from other anatomical sites. PACC, lacking mutations in a majority of non-small cell lung cancer driver genes, has frequent mutations in genes participating in chromatin remodeling and NOTCH signaling pathway. We also elucidated spatial intra-tumoral heterogeneity, which varied among cases. Most mutations in chromatin remodelers were subclonal. Collectively, our findings elucidated molecular signature associated with PACC and highlighted the potential for epigenetic therapy in this disease.

PMID: 30067437 [PubMed - as supplied by publisher]

Innovative SolutIons for DosimEtry in Hadrontherapy (INSIDE)

Posted: September 7th, 2018, 2:00pm GMT

Condition: Particle Therapy
Interventions: Radiation: carbon ions radiation therapy; Radiation: protons radiation therapy
Sponsor: CNAO National Center of Oncological Hadrontherapy
Not yet recruiting

Chidamide Combined With Cisplatin in Head and Neck Adenoid Cystic Carcinoma (HNACC)

Posted: August 21st, 2018, 2:00pm GMT

Conditions: Adenoid Cystic Carcinomas; Chidamide; Cisplatin
Intervention: Drug: Chidamide combined with cisplatin
Sponsor: Fudan University
Recruiting

Study of Intratumoral CV8102 in cMEL, cSCC, hnSCC, and ACC

Posted: September 25th, 2017, 2:00pm GMT

Conditions: Melanoma (Skin); Squamous Cell Carcinoma of the Skin; Carcinoma, Squamous Cell of Head and Neck; Carcinoma, Adenoid Cystic
Interventions: Biological: CV8102; Biological: CV8102 + anti-PD-1 therapy
Sponsor: CureVac AG
Recruiting

$Permalink for 'Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers'$

Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers

Posted: December 1st, 2016, 3:00pm GMT

Conditions: Adenoid Cystic Carcinoma; Adnexal Carcinoma; Apocrine Carcinoma; Eccrine Porocarcinoma; Extraocular Cutaneous Sebaceous Carcinoma; Hidradenocarcinoma; Keratoacanthoma; Malignant Sweat Gland Neoplasm; Merkel Cell Carcinoma; Microcystic Adnexal Carcinoma; NK-Cell Lymphoma, Unclassifiable; Non-Melanomatous Lesion; Paget Disease; Papillary Adenocarcinoma; Primary Cutaneous Mucinous Carcinoma; Refractory Anaplastic Large Cell Lymphoma; Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Refractory Mycosis Fungoides; Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma; Refractory T-Cell Non-Hodgkin Lymphoma; Sezary Syndrome; Signet Ring Cell Carcinoma; Skin Basal Cell Carcinoma; Skin Basosquamous Cell Carcinoma; Skin Squamous Cell Carcinoma; Spiradenocarcinoma; Squamous Cell Carcinoma of Unknown Primary Origin; Stage III Skin Cancer; Stage IV Skin Cancer; Sweat Gland Carcinoma; Trichilemmocarcinoma; Vulvar Squamous Cell Carcinoma
Interventions: Other: Laboratory Biomarker Analysis; Biological: Nivolumab; Biological: Talimogene Laherparepvec
Sponsor: National Cancer Institute (NCI)
Recruiting

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

Posted: July 15th, 2016, 2:00pm GMT

The cancer patient had exhausted his options. Enter immunotherapy. - Crain's Chicago Business

Posted: September 14th, 2018, 5:49pm GMT

Crain's Chicago Business

The cancer patient had exhausted his options. Enter immunotherapy.
Crain's Chicago Business
Suddenly, the nightmare returned: Doctors told him his adrenal cancer had metastasized into countless tumors speckled across his lungs. Doctors tried to destroy the tumors with chemotherapy, which wiped Hill out. He slept 21 hours a day. Six weeks into ...

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Posted: August 30th, 2018, 5:00am GMT

This RSS feed URL is deprecated, please update. New URLs can be found in the footers at [https:]

Permalink for 'Adrenal Cortical Carcinoma Diagnosis and Treatment Market Research by Key Players, Type and Application, Future ... - Digital Journal'

Adrenal Cortical Carcinoma Diagnosis and Treatment Market Research by Key Players, Type and Application, Future ... - Digital Journal

Posted: August 10th, 2018, 4:31am GMT

Adrenal Cortical Carcinoma Diagnosis and Treatment Market Research by Key Players, Type and Application, Future ...
Digital Journal
Functioning tumor is responsible for increase in the production of adrenal hormones, whereas, non-functioning tumor does not affect hormonal production. Adrenal cortical carcinoma is generally a secondary type of cancer. It occurs when another form of ...

Cancer drug earns FDA nod after decades - Medical Xpress

Posted: August 8th, 2018, 12:26pm GMT

Medical Xpress

Cancer drug earns FDA nod after decades
Medical Xpress
Azedra is "a bit like a magic bullet" for rare adrenal tumours that can't be surgically removed and require systemic anti-cancer therapy. The compound is highly radioactive and, once injected intravenously is specifically absorbed by, and then attacks ...

Global Adrenocortical Carcinoma (Adrenal Cortex Cancer) Ongoing Clinical Trials - Analysis & Outlook to 2022 ... - Digital Journal

Posted: August 1st, 2018, 7:38am GMT

Global Adrenocortical Carcinoma (Adrenal Cortex Cancer) Ongoing Clinical Trials - Analysis & Outlook to 2022 ...
Digital Journal
Adrenocortical Carcinoma (Adrenal Cortex Cancer) ongoing clinical trials report provides comprehensive analysis and trends in global Adrenocortical Carcinoma (Adrenal Cortex Cancer) disease clinical trials. The research work analyzes the ongoing ...

This RSS feed URL is deprecated

Posted: August 30th, 2018, 5:00am GMT

This RSS feed URL is deprecated, please update. New URLs can be found in the footers at [https:]

Permalink for 'Cytotoxic T Lymphocyte Protein 4 - Pipeline Review, H2 2018 Market Report; Launched via MarketResearchReports.com - Digital Journal'

Cytotoxic T Lymphocyte Protein 4 - Pipeline Review, H2 2018 Market Report; Launched via MarketResearchReports.com - Digital Journal

Posted: August 21st, 2018, 2:22pm GMT

Cytotoxic T Lymphocyte Protein 4 - Pipeline Review, H2 2018 Market Report; Launched via MarketResearchReports.com
Digital Journal
... Peritoneal Cancer, Vaginal Cancer, Vulvar Cancer, Adrenal Gland Cancer, Adrenocortical Carcinoma (Adrenal Cortex Cancer), Advanced Malignancy, Anal Cancer, Basal Cell Carcinoma (Basal Cell Epithelioma), Bile Duct Cancer (Cholangiocarcinoma), ...

Global Adrenocortical Carcinoma (Adrenal Cortex Cancer) Ongoing Clinical Trials - Analysis & Outlook to 2022 ... - Digital Journal

Posted: August 1st, 2018, 7:38am GMT

Global Adrenocortical Carcinoma (Adrenal Cortex Cancer) Ongoing Clinical Trials - Analysis & Outlook to 2022 ...
Digital Journal
Adrenocortical Carcinoma (Adrenal Cortex Cancer) ongoing clinical trials report provides comprehensive analysis and trends in global Adrenocortical Carcinoma (Adrenal Cortex Cancer) disease clinical trials. The research work analyzes the ongoing ...

Aloha! Mint Hill - Mint Hill Times

Posted: July 4th, 2018, 2:05am GMT

Mint Hill Times

Aloha! Mint Hill
Mint Hill Times
Two and a half years ago, rising Queen's Grant fourth grader Damon Gammon was diagnosed with Adrenocortical Carcinoma, a rare and aggressive form of cancer. The disease is diagnosed in only about 200 people total in the United States per year, and ...

Permalink for 'Evaluation, Staging, and Surgical Management for Adrenocortical Carcinoma: An Update from the SSO Endocrine and Head and Neck Disease Site Working Group.'

Evaluation, Staging, and Surgical Management for Adrenocortical Carcinoma: An Update from the SSO Endocrine and Head and Neck Disease Site Working Group.

Fetched: September 21st, 2018, 5:00am GMT

Evaluation, Staging, and Surgical Management for Adrenocortical Carcinoma: An Update from the SSO Endocrine and Head and Neck Disease Site Working Group.

Ann Surg Oncol. 2018 Sep 18;:

Authors: Dickson PV, Kim L, Yen TWF, Yang A, Grubbs EG, Patel D, Solórzano CC

Abstract
This is the first of a two-part review on adrenocortical carcinoma (ACC), a rare and aggressive malignancy that often presents at an advanced stage. Most patients present with symptoms related to cortisol and/or androgen excess. Appropriate biochemical evaluation and imaging is important in assessing the extent of disease, operative planning, and oncologic surveillance for patients with ACC. For patients with locoregional disease, potential cure requires margin-negative resection, and accumulating evidence suggests that regional lymphadenectomy should be performed. Although laparoscopic adrenalectomy is reported by some to be adequate for localized ACC, open resection in the hands of an experienced adrenal surgeon is the gold standard for operative management of this disease. Cure is rare following disease relapse, however select patients with severe symptoms related to hormone excess or pain may benefit from resection of local or distant recurrence. For best oncologic outcomes, it is recommended that all patients with ACC be treated at centers with multidisciplinary expertise in management of this rare and aggressive malignancy.

PMID: 30229419 [PubMed - as supplied by publisher]

Permalink for 'Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review.'

Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review.

Fetched: September 21st, 2018, 5:00am GMT

Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review.

BMC Endocr Disord. 2018 Mar 27;18(1):19

Authors: Iwayama H, Hirase S, Nomura Y, Ito T, Morita H, Otake K, Okumura A, Takagi J

Abstract
BACKGROUND: Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed previous cases of ectopic ACTH production suppressed via steroidogenesis inhibition.
CASE PRESENTATION: A 71-year-old female with general fatigue, central obesity and impaired glucose tolerance was diagnosed with Cushing's syndrome due to elevated ACTH (192.9 pg/mL; normal range, 7.2-63.3 pg/mL), cortisol (73.1 μg/dL; 6.4-21.0 μg/dL) and 24-h urinary free cortisol (UFC) (6160 μg/day; 11.2-80.3 μg/day) levels. Chest computed tomography identified a solid 26.6 × 22.9 × 30.0 mm tumour with a cavity in the upper lobe of the left lung. There was no adrenal gland enlargement. Tumour markers were not significantly elevated; ACTH levels were not suppressed by 8-mg dexamethasone. A corticotropin-releasing hormone stimulation test revealed blunted ACTH response (basal ACTH, 204.6 pg/mL; highest ACTH level during the 120-min stimulation test, 214.0 pg/mL). She was diagnosed with EAS due to a lung lesion. MTP treatment was started to reduce cortisol production. ACTH levels and cortisol and UFC levels were normalised and the ACTH-producing lung tumour was ablated after MTP treatment. In several reported cases, plasma ACTH levels reduced during steroidogenesis inhibitor treatment for EAS. Among the 10 patients, three cases of pheochromocytoma, one of thymic carcinoid and one of islet cell carcinoma were reported. In four cases, the tumour was not detected. In our case, the pathology of the lung tumour was unknown because of lack of tumour cells in biopsy. The patients were treated with ketoconazole (KTZ) and/or MTP and exhibited ACTH and cortisol/UFC suppression, but tumour regression was observed only in our case.
CONCLUSION: MTP and/or KTZ may reduce ACTH and cortisol production. The tumour spontaneously regressed after MTP treatment, indicating that MTP may reduce the tumour size without surgery. The mechanisms of therapeutic effects of steroidogenesis inhibitors and prognosis of spontaneous remission should be elucidated further via molecular biology studies.

PMID: 29587720 [PubMed - indexed for MEDLINE]

Use of Contrast-Enhanced Ultrasound in the Differential Diagnosis of Adrenal Tumors in Dogs.

Fetched: September 21st, 2018, 5:00am GMT

Use of Contrast-Enhanced Ultrasound in the Differential Diagnosis of Adrenal Tumors in Dogs.

J Am Anim Hosp Assoc. 2016 May-Jun;52(3):132-43

Authors: Bargellini P, Orlandi R, Dentini A, Paloni C, Rubini G, Fonti P, Diana A, Peterson ME, Boiti C

Abstract
We evaluated the diagnostic accuracy of the contrast-enhanced ultrasonography (CEUS), using a second-generation microbubble contrast agent, in differentiating the different types of adrenal mass lesions in 24 dogs. At B-mode ultrasound, 9 lesions involved the right adrenal gland, 14 the left, and 1 was bilateral. Each dog received a bolus of the contrast agent into the cephalic vein, immediately followed by a 5-mL saline flush. The first contrast enhancement of each adrenal lesion was evaluated qualitatively to assess the degree of enhancement and its distribution during the wash-in and wash-out phases, as well as the presence of non-vascularized areas and specific vascular patterns. Pathological diagnoses were determined in all dogs by histopathology or by cytology. Combining enhancement degree and vascularity resulted in the best predictive model, allowing CEUS to differentiate adrenocortical adenoma (n=10), adenocarcinoma (n=7), and pheochromocytoma (n=7) with an accuracy of 91.7% (P < 0.001). Combining enhancement degree and vascularity, CEUS can discriminate malignant versus benign adrenal lesions with a sensitivity of 100.0%, a specificity of 80.0%, and an accuracy of 91.7% (P < 0.001). In conclusion, results of this study confirm that CEUS is useful for differentiating between the different types of adrenal tumors in dogs.

PMID: 27008325 [PubMed - indexed for MEDLINE]

Congenital Adrenal Hyperplasia with 11-Beta Hydroxylase Deficiency with Testicular Adrenal Rest Tumour.

Fetched: September 20th, 2018, 5:00am GMT

Congenital Adrenal Hyperplasia with 11-Beta Hydroxylase Deficiency with Testicular Adrenal Rest Tumour.

J Assoc Physicians India. 2017 Jun;65(6):97-99

Authors: Sonawale A, Rajadhyaksha A, Warrier S, Shriwastav R, Sabnis NH

Abstract
Congenital adrenal hyperplasia refers to the non-malignant enlargement of adrenal gland tissue as a result of deficiency of one of several enzymes involved in adrenal hormone synthesis, secondary to a genetic mutation. 11 - Beta hydroxylase is one such enzyme, and its deficiency is a rare cause of Congenital Adrenal Hyperplasia. We describe the case of an 18-year old man who presented to us with an acute right ganglio-capsular bleed, hypertension and bilateral scrotal swelling. Investigations revealed hypokalemia, and normal renal and cardiac functions. Furthermore, sex hormone levels were found to be markedly raised, and Renin to Aldosterone ratio was also deranged. CT imaging of the adrenals confirmed hyperplasia, and ultrasound of the testes confirmed Testicular Adrenal Rest tumour, a rare finding. His condition improved significantly with treatment, and he is currently undergoing physical and occupational rehabilitation. Our case highlights the importance of evaluation of hypertension in young patients and a high degree of suspicion for rarer causes.

PMID: 28782322 [PubMed - indexed for MEDLINE]

Fetal exposure to mitotane/Op'DDD: post-natal study of four children.

Fetched: September 19th, 2018, 5:00am GMT

Fetal exposure to mitotane/Op'DDD: post-natal study of four children.

Clin Endocrinol (Oxf). 2018 Sep 17;:

Authors: Magkou D, DoCao C, Bouvattier C, Douillard C, de Marcellus C, Cazabat L, Gérard M, Raffin-Sanson ML, Young J

Abstract
OBJECTIVE: Mitotane/o,p'DDD is used in the treatment of adrenocortical carcinoma and for other causes of hypercortisolism. Mitotane inhibits cortisol secretion and displays adrenolytic and antitumor actions. This compound is a metabolite of the pesticide and endocrine disruptor DDT (Dichlorodiphenyltrichloroethane) and is classified among teratogenic compounds worldwide. However, little is known about its effects on human development.
DESIGN: The outcome of four children exposed to mitotane during their intrauterine life was examined.
PATIENTS: Patients having conceived while taking mitotane, or with detectable mitotane plasma levels, were retrospectively recruited via the French COMETE and FIRENDO networks.
MEASUREMENTS: Mitotane in maternal plasma, adrenocortical hormones in children.
RESULTS: Three women treated with mitotane gave birth to four children. During early pregnancy, all patients had detectable mitotane plasma levels (0.9, 2.4 and 6.7 mg/L respectively). During pregnancy, no fetal malformations were detected. The four exposed newborns presented at birth with apparently normal adrenal function and genitalia. One twin female had a low birth weight. Evaluation at birth and after 3 months, 2 years and 7 years of follow-up showed no significant neurological abnormality. Evaluation of adrenocortical functions showed no cortisol deficiency.
CONCLUSIONS: Unexpectedly, exposure of these four children to mitotane during fetal life seemed to have no clear teratogenic effect. However, considering the sub-therapeutic mitotane concentrations used here, the small number of cases, and because long term follow- up is unknown, we strongly advise not to take mitotane during pregnancy and still recommend avoiding pregnancy, at least as long as mitotane plasma levels remain detectable. This article is protected by copyright. All rights reserved.

PMID: 30222204 [PubMed - as supplied by publisher]

Clinical and molecular prognostic factors in adrenocortical carcinomas.

Fetched: September 19th, 2018, 5:00am GMT

Clinical and molecular prognostic factors in adrenocortical carcinomas.

Minerva Endocrinol. 2018 Sep 12;:

Authors: Libé R

Abstract
INTRODUCTION: Adrenocortical carcinoma (ACC) is a rare cancer, with an incidence less than 0.7-1.5 per 1 million people per year, with a poor prognosis. The overall survival (OS) depens on the ENSAT stage: in particular in metastatic ACC the OS varies between 10 and 20 months, with a 5-yrs survival around 10%. ACC present a different behaviour, probably due to a different biology. For these reason a careful prognostic classification is mandatory, in order to stratify the patients and purpose a specific management.
EVIDENCE ACQUISITION: Prognostic factors can be divides in three groups: clinical factors (tumor stage, Age, hormone- related symptoms), pathological factor (Weiss score, mitotic count, Ki67,SF-1 and AVA2, P53, beta-catenin immunohistochemistry, resection status), molecular factor (chromosomal aberrations, methylation profile, altered gene expression and miRNA expression, gene mutations).
EVIDENCE SYNTHESIS: The best way in order to stratify ACC patients and purpose the best therapeutic option is to combine clinical, pathological and molecular factors.
CONCLUSIONS: Individualizing patients' prognosis and tumor biology appears as a necessary step for personalized medicine. In addition to tumor stage and tumor grade, the genomic classification may precise the risk stratification and thus help defining therapeutic strategy.

PMID: 30221891 [PubMed - as supplied by publisher]

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Fetched: September 1st, 2018, 5:00am GMT

Fetched: September 1st, 2018, 5:00am GMT

Fetched: August 31st, 2018, 5:00am GMT

Fetched: August 26th, 2018, 5:00am GMT

Fetched: August 23rd, 2018, 5:00am GMT

Fetched: August 23rd, 2018, 5:00am GMT

Fetched: August 22nd, 2018, 5:00am GMT

Fetched: August 17th, 2018, 5:00am GMT

Fetched: August 17th, 2018, 5:00am GMT

Fetched: August 15th, 2018, 5:00am GMT

Fetched: August 15th, 2018, 5:00am GMT

Fetched: August 14th, 2018, 5:00am GMT

Fetched: August 14th, 2018, 5:00am GMT

Fetched: August 12th, 2018, 5:00am GMT