Allison Kuban never expected to hear that she had pancreatic cancer after she suddenly began having stomach pains. But on her 31st birthday, her world was ...
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Google - Acinar Cell Carcinoma
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Stage 4 pancreatic cancer survivor shares inspiring story - KTRK-TV
Posted: May 17th, 2019, 5:00am GMT
Stage 4 pancreatic cancer survivor shares inspiring story KTRK-TV -
Kaplan USMLE Step 1 prep: Woman has excessive thirst, urination - American Medical Association
Posted: May 14th, 2019, 10:00am GMT
Kaplan USMLE Step 1 prep: Woman has excessive thirst, urination American Medical AssociationThe case: A 38-year-old woman has had excessive thirst and urination for four weeks. What cell is the pancreatic tumor from?
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Feliciano Determines Which Patients Are Best Served by Either Immunotherapy or Targeted... - Targeted Oncology
Posted: April 25th, 2019, 11:18pm GMT
Feliciano Determines Which Patients Are Best Served by Either Immunotherapy or Targeted... Targeted OncologyDuring a Targeted Oncology live case-based peer perspectives presentation, Josephine Louella Feliciano, MD, explained the treatment considerations and ...
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Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring - Nature.com
Posted: April 17th, 2019, 3:03pm GMT
Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring Nature.comPancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic ...
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Hydrogel microenvironments for cancer spheroid growth and drug screening - Science Advances
Posted: April 15th, 2019, 10:30pm GMT
Hydrogel microenvironments for cancer spheroid growth and drug screening Science AdvancesMulticellular cancer spheroids (MCSs) have emerged as a promising in vitro model that replicates many features of solid tumors in vivo. Biomimetic hydrogel ...
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Scientists delineate pathway that helps us make antibodies - Science Daily
Posted: March 13th, 2019, 5:00am GMT
Scientists delineate pathway that helps us make antibodies Science DailyOur bodies are continuously concocting specific antibodies to thwart invaders like a virus or even pollen, and scientists have new information about how the ...
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Phosphatidylinositol Biphosphate (PIP2) Signal Pathway - News-Medical.net
Posted: February 26th, 2019, 6:00am GMT
Phosphatidylinositol Biphosphate (PIP2) Signal Pathway News-Medical.netBy Jeyashree Sundaram, MBA. Phosphatidylinositol 4,5-bisphosphate (PIP2) is an essential lipid involved in metabolic processes. It is integral to the cell ...
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Ibrutinib Combo Falls Short in Pancreatic Cancer - OncLive
Posted: January 22nd, 2019, 2:06pm GMT
Ibrutinib Combo Falls Short in Pancreatic Cancer OncLiveThe frontline combination of ibrutinib (Imbruvica) and nab-paclitaxel (Abraxane)/gemcitabine did not show a statistically significant benefit in progression-free or ...
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No Survival Improvement Seen With Ibrutinib Combination in Pancreatic Cancer - Targeted Oncology
Posted: January 22nd, 2019, 6:00am GMT
No Survival Improvement Seen With Ibrutinib Combination in Pancreatic Cancer Targeted OncologyFrontline treatment with ibrutinib plus nab-paclitaxel/gemcitabine did not have a statistically significant benefit in progression-free survival or overall survival ...
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Grantee Studies Cellular Changes to Stop Pancreatic Cancer Tumors - Pancreatic Cancer News & Stories
Posted: January 15th, 2019, 6:00am GMT
Grantee Studies Cellular Changes to Stop Pancreatic Cancer Tumors Pancreatic Cancer News & StoriesRecently published in Cancer Discovery, PanCAN grantee Kathryn Wellen, PhD, describes how blocking changes in cells' ability to break down nutrients could ...
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Surgery unnecessary for many prostate cancer patients - Medical Xpress
Posted: December 13th, 2018, 6:00am GMT
Surgery unnecessary for many prostate cancer patients Medical XpressOtherwise healthy men with advanced prostate cancer may benefit greatly from surgery, but many with this diagnosis have no need for it. These conclusions ...
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Pulling the genome apart: Chromosome segregation during mitosis explained - Phys.org
Posted: November 13th, 2018, 6:00am GMT
Pulling the genome apart: Chromosome segregation during mitosis explained Phys.orgWhen a cell divides—a process known as mitosis—its chromosomes need to be separated and evenly distributed into the newly created daughter cells.
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Efficacy, effectiveness, and safety of herpes zoster vaccines in adults aged 50 and older: systematic review and network meta-analysis - The BMJ
Posted: October 25th, 2018, 5:00am GMT
Efficacy, effectiveness, and safety of herpes zoster vaccines in adults aged 50 and older: systematic review and network meta-analysis The BMJBMJ 2018; 363 doi: [https:] (Published 25 October 2018) Cite this as: BMJ 2018;363:k4029. Linked Editorial. Which shingles vaccine ...
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New kind of compound shows early promise against prostate cancer - Medical Xpress
Posted: October 23rd, 2018, 5:00am GMT
New kind of compound shows early promise against prostate cancer Medical XpressA new type of molecule blocks the action of genes that drive the growth of therapy-resistant prostate cancer, a new study finds.
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Rare Prostate Cancer Associated with Cushing’s Syndrome in Case Report - Cushing's Disease News
Posted: October 16th, 2018, 5:00am GMT
Rare Prostate Cancer Associated with Cushing’s Syndrome in Case Report Cushing's Disease NewsA patient with depression developed Cushing's syndrome (CS) because of a rare ACTH-secreting small cell cancer of the prostate, a case study reports.
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Nanoparticle therapeutic restores function of tumor suppressor in prostate cancer - Medical Xpress
Posted: September 17th, 2018, 5:00am GMT
Nanoparticle therapeutic restores function of tumor suppressor in prostate cancer Medical XpressThink of it as a cancer therapy zag instead of a zig. While many groups are developing cancer therapies to target proteins and pathways that are highly active in ...
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Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis - Journal of Virology
Posted: August 28th, 2018, 11:00am GMT
Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis Journal of VirologyViral myocarditis, which is most prevalently caused by coxsackievirus B3 (CVB3), is a serious clinical condition characterized by excessive myocardial ...
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Phosphatidylinositol Biphosphate (PIP2) Signal Pathway - News-Medical.net
Posted: August 23rd, 2018, 5:00am GMT
Phosphatidylinositol Biphosphate (PIP2) Signal Pathway News-Medical.netBy Jeyashree Sundaram, MBA. Phosphatidylinositol 4,5-bisphosphate (PIP2) is an essential lipid involved in metabolic processes. It is integral to the cell ...
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Microcalcifications in Breast Cancer - News-Medical.net
Posted: August 2nd, 2018, 1:21am GMT
Microcalcifications in Breast Cancer News-Medical.netCalcifications in the breast can be benign or malignant. They can appear as either macrocalcifications or microcalcifications on a mammogram (i.e. an X-ray of ...
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Microcalcifications in Breast Cancer - News-Medical.net
Posted: August 2nd, 2018, 1:21am GMT
Microcalcifications in Breast Cancer News-Medical.netCalcifications in the breast can be benign or malignant. They can appear as either macrocalcifications or microcalcifications on a mammogram (i.e. an X-ray of ...
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Discovering the mechanisms that underlie prostate cancer - Medical Xpress
Posted: July 12th, 2018, 5:00am GMT
Discovering the mechanisms that underlie prostate cancer Medical XpressNew research has uncovered insights into the mechanisms that underlie prostate cancer, providing potential targets for new cancer therapies.
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EGFR+ NSCLC - Targeted Oncology
Posted: June 29th, 2018, 5:15pm GMT
EGFR+ NSCLC Targeted OncologyMark Socinski, MD, outlines the diagnosis and treatment of a 66-year-old Asian woman who presents with EGFR+ non-small cell lung cancer.
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Acinic Cell Carcinoma - News-Medical.net
Posted: June 20th, 2018, 11:29pm GMT
Acinic Cell Carcinoma News-Medical.netAs salivary glands are made up of different cells, tumors could start in any one of such. Various salivary gland tumors, which may be benign or malignant, may ...
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Acinic Cell Carcinoma - News-Medical.net
Posted: June 20th, 2018, 11:29pm GMT
Acinic Cell Carcinoma News-Medical.netAs salivary glands are made up of different cells, tumors could start in any one of such. Various salivary gland tumors, which may be benign or malignant, may ...
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Fewer men are being screened, diagnosed, and treated for prostate cancer - Medical Xpress
Posted: May 21st, 2018, 5:00am GMT
Fewer men are being screened, diagnosed, and treated for prostate cancer Medical XpressA new study reveals declines in prostate cancer screening and diagnoses in the United States in recent years, as well as decreases in the use of definitive ...
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LI scientist paves the way for halting pancreatic cancer's spread - Newsday
Posted: May 17th, 2018, 5:00am GMT
LI scientist paves the way for halting pancreatic cancer's spread NewsdayOn Wednesday, Dr. Douglas Fearon, a scientist at Cold Spring Harbor Laboratory, discussed his discovery that dormant pancreatic cancer cells are lying in wait ...
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Hydrogel microenvironments for cancer spheroid growth and drug screening - Science Advances
Posted: April 27th, 2018, 5:00am GMT
Hydrogel microenvironments for cancer spheroid growth and drug screening Science AdvancesMulticellular cancer spheroids (MCSs) have emerged as a promising in vitro model that replicates many features of solid tumors in vivo. Biomimetic hydrogel ...
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Hydrogel microenvironments for cancer spheroid growth and drug screening - Science Advances
Posted: April 27th, 2018, 5:00am GMT
Hydrogel microenvironments for cancer spheroid growth and drug screening Science AdvancesMulticellular cancer spheroids (MCSs) have emerged as a promising in vitro model that replicates many features of solid tumors in vivo. Biomimetic hydrogel ...
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EGFR+ Non-Small Cell Lung Cancer: Frontline Options - Targeted Oncology
Posted: April 13th, 2018, 5:00am GMT
EGFR+ Non-Small Cell Lung Cancer: Frontline Options Targeted OncologyMark Socinski, MD, shares insight on the frontline systemic therapy options available for EGFR-mutant NSCLC treatment and considers multidisciplinary care in ...
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EGFR+ NSCLC: Treatment Through Multiple Lines of Therapy - Targeted Oncology
Posted: April 13th, 2018, 5:00am GMT
EGFR+ NSCLC: Treatment Through Multiple Lines of Therapy Targeted OncologyMark Socinski, MD, discusses his recommendations if a patient with EGFR-mutant non-small cell lung cancer develops disease progression through multiple ...
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Approaching a Case of EGFR+ Non-Small Cell Lung Cancer - Targeted Oncology
Posted: April 13th, 2018, 5:00am GMT
Approaching a Case of EGFR+ Non-Small Cell Lung Cancer Targeted OncologyMark Socinski, MD, outlines the diagnosis and treatment of a 66-year-old Asian woman who presents with EGFR+ non-small cell lung cancer and reviews ...
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Metabolic profiling may determine aggressiveness, prognosis of prostate cancer - Medical Xpress
Posted: March 26th, 2018, 5:00am GMT
Metabolic profiling may determine aggressiveness, prognosis of prostate cancer Medical XpressA new approach to analyzing prostate gland tissue may help address a major challenge in treating prostate cancer - determining which tumors are unlikely to ...
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Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors - Science
Posted: March 13th, 2018, 5:00am GMT
Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors SciencePredicting how a tumor can adapt to a drug may help identify the patients most likely to respond as well as strategies to avoid resistance. Activation of the kinase ...
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TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease - AJP-Lung Physiology (subscription)
Posted: March 13th, 2018, 1:52am GMT
TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease AJP-Lung Physiology (subscription)Epithelial-mesenchymal transition (EMT), a process whereby fully differentiated epithelial cells undergo transition to a mesenchymal phenotype giving rise to ...
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Could Cassava leaves and roots extract be the Magic cure for colon, prostate and bladder cancers? - Modern Ghana
Posted: March 2nd, 2018, 6:00am GMT
Could Cassava leaves and roots extract be the Magic cure for colon, prostate and bladder cancers? Modern GhanaGrowing up in my village called Suhum-Amanhia on the Koforidua road; I quite remembered we were told of the two main varieties of cassava: The one eatable ...
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Norwich man trying to raise £70,000 for rare cancer treatment | Health - Norfolk Eastern Daily Press
Posted: February 14th, 2018, 6:00am GMT
Norwich man trying to raise £70,000 for rare cancer treatment | Health Norfolk Eastern Daily PressDamion Burbank has been diagnosed with a rare form of cancer, the family are hoping to rasie money to pay for treatments abroad. Damion at home with his ...
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Cell-cell adhesion in lung endothelium - AJP-Lung Physiology (subscription)
Posted: December 9th, 2017, 1:18pm GMT
Cell-cell adhesion in lung endothelium AJP-Lung Physiology (subscription)Homotypic cell-cell adhesion is essential for tissue and organ development, remodeling, regeneration, and physiological function. Whereas a significant number ...
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Pancreatic cancer: specific protein promotes development of pancreatitis and tumours - Drug Target Review
Posted: December 6th, 2017, 6:00am GMT
Pancreatic cancer: specific protein promotes development of pancreatitis and tumours Drug Target ReviewA study has shown that disruption to cell autophagy is involved in the development of pancreatic cancer.
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Fast Five Quiz: Prostate Cancer - Medscape
Posted: October 15th, 2017, 4:04am GMT
Fast Five Quiz: Prostate Cancer MedscapeProstate cancer is the most common noncutaneous cancer in men and is the second most common cause of cancer deaths. Do you know what to watch for and ...
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A versatile 3D tissue matrix scaffold system for tumor modeling and drug screening - Science Advances
Posted: September 13th, 2017, 5:00am GMT
A versatile 3D tissue matrix scaffold system for tumor modeling and drug screening Science AdvancesMost of the anticancer drug candidates entering preclinical trials fail to be approved for clinical applications. The following are among the main causes of these ...
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Functional Optical Imaging of Primary Human Tumor Organoids: Development of a Personalized Drug Screen - Journal of Nuclear Medicine
Posted: September 1st, 2017, 5:00am GMT
Functional Optical Imaging of Primary Human Tumor Organoids: Development of a Personalized Drug Screen Journal of Nuclear Medicine+ Author Affiliations. 1Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee. 2Department of Cancer Biology, Vanderbilt University ...
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Types of Hematuria - News-Medical.net
Posted: August 3rd, 2017, 11:18am GMT
Types of Hematuria News-Medical.netHematuria is a health condition that is characterized by the presence of blood in the urine. There are two main types of hematuria: microscopic and macroscopic.
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Types of Hematuria - News-Medical.net
Posted: August 3rd, 2017, 11:18am GMT
Types of Hematuria News-Medical.netHematuria is a health condition that is characterized by the presence of blood in the urine. There are two main types of hematuria: microscopic and macroscopic.
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Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites - Science Advances
Posted: June 2nd, 2017, 5:00am GMT
Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites Science AdvancesIslet transplantation is a promising alternative therapy for insulin-dependent patients, with the potential to eliminate life-threatening hypoglycemic episodes and ...
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No prescription synthroid - Study of Sports
Posted: May 15th, 2017, 5:00am GMT
No prescription synthroid Study of SportsNo prescription synthroid. Synthroid 40mg, Buy synthroid without prescription. No prescription needed, approved pharmacy. Best Quality and EXTRA LOW ...
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Can Artificial Sweeteners Reduce Pancreatic Cancer Risk? - News-Medical.net
Posted: May 4th, 2017, 5:00am GMT
Can Artificial Sweeteners Reduce Pancreatic Cancer Risk? News-Medical.netPancreatic cancer claims the fourth highest spot on the list of cancer-related mortality, despite the fact that it doesn't even make the top ten for incidence.
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Can Artificial Sweeteners Reduce Pancreatic Cancer Risk? - News-Medical.net
Posted: May 4th, 2017, 5:00am GMT
Can Artificial Sweeteners Reduce Pancreatic Cancer Risk? News-Medical.netPancreatic cancer claims the fourth highest spot on the list of cancer-related mortality, despite the fact that it doesn't even make the top ten for incidence.
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Casper fire captain dies of cancer, the first firefighter to qualify under new workers compensation law - Casper Star-Tribune Online
Posted: April 24th, 2017, 5:00am GMT
Casper fire captain dies of cancer, the first firefighter to qualify under new workers compensation law Casper Star-Tribune OnlineA Casper firefighter died Saturday night after an extended battle with pancreatic cancer.
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Casper fire captain dies of cancer, the first firefighter to qualify under new workers compensation law - Casper Star-Tribune Online
Posted: April 24th, 2017, 5:00am GMT
Casper fire captain dies of cancer, the first firefighter to qualify under new workers compensation law Casper Star-Tribune OnlineA Casper firefighter died Saturday night after an extended battle with pancreatic cancer.
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Study provides path for new immunotherapy approaches to prostate cancer - Medical Xpress
Posted: March 27th, 2017, 5:00am GMT
Study provides path for new immunotherapy approaches to prostate cancer Medical XpressProstate cancer, notoriously resistant to immunotherapy due to its immunologically cool nature, triggers two pathways to chill an immune attack after one ...
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Primary pancreatic lymphoma: two case reports and a literature review | OTT - Dove Medical Press
Posted: March 20th, 2017, 5:00am GMT
Primary pancreatic lymphoma: two case reports and a literature review | OTT Dove Medical PressPrimary pancreatic lymphoma: two case reports and a literature review Lili Yu,1,2,* Yajun Chen,1,2,* Ligang Xing2 1School of Medicine and Life Sciences, ...
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Therapeutic Implications of Molecular Subtyping for Pancreatic Cancer - Cancer Network
Posted: March 15th, 2017, 5:00am GMT
Therapeutic Implications of Molecular Subtyping for Pancreatic Cancer Cancer NetworkIn this article, we review seminal articles that have evaluated the molecular architecture of pancreatic cancer. We compare the methods used and the molecular ...
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Adenosquamous Carcinoma of the Prostate: A Rare Aggressive Tumor with a Review of the Literature - UroToday
Posted: January 31st, 2017, 11:31am GMT
Adenosquamous Carcinoma of the Prostate: A Rare Aggressive Tumor with a Review of the Literature UroTodayABSTRACT. Adenosquamous carcinoma (ASCC) of the prostate is an extremely rare, aggressive neoplasm with only few cases are reported in literature.
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Adenosquamous Carcinoma of the Prostate: A Rare Aggressive Tumor with a Review of the Literature - UroToday
Posted: January 31st, 2017, 11:31am GMT
Adenosquamous Carcinoma of the Prostate: A Rare Aggressive Tumor with a Review of the Literature UroTodayABSTRACT. Adenosquamous carcinoma (ASCC) of the prostate is an extremely rare, aggressive neoplasm with only few cases are reported in literature.
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UCSD helps lead ambitious study of 80 rare cancers - sandiegouniontribune.com
Posted: January 18th, 2017, 6:00am GMT
UCSD helps lead ambitious study of 80 rare cancers The San Diego Union-TribuneUC San Diego researchers are playing big roles in an innovative, nationwide clinical trial to see whether 80 rare cancers can be treated with drugs from the ...
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Parotid Tumors in Children | Plastic Surgery | AAP Pediatrics - AAP Grand Rounds
Posted: November 24th, 2016, 7:19am GMT
Parotid Tumors in Children | Plastic Surgery | AAP Pediatrics AAP Grand RoundsSource: Allan BJ, Tashiro J, Diaz S, et al. Malignant tumors of the parotid gland in children: incidence and outcomes. J Craniofac Surg . 2013; 24( 5): 1660– 1664 ...
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Pancreatic Enzyme Replacement Therapy: A View From Behind the Counter - Pharmacy Times
Posted: September 21st, 2016, 5:00am GMT
Pancreatic Enzyme Replacement Therapy: A View From Behind the Counter Pharmacy TimesUnderdosing.1 Noncompliance.2,3 Unclear treatment expectations.4 These are some of the ongoing challenges associated with pancreatic enzyme ...
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Survival Outcomes in Gleason 9-10 PCa Similar With Radiation, Surgery - Renal and Urology News
Posted: August 2nd, 2016, 5:00am GMT
Survival Outcomes in Gleason 9-10 PCa Similar With Radiation, Surgery Renal and Urology NewsRadiation therapy and radical prostatectomy (RP) offer men with Gleason score 9–10 prostate cancer (PCa) equivalent cancer-specific and overall survival, ...
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68Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer - Journal of Nuclear Medicine
Posted: June 3rd, 2016, 5:00am GMT
68Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer Journal of Nuclear Medicine+ Author Affiliations. 1Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany. 2Institute for Clinical Radiology, ...
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Combination Immunotherapy Shows New Promise for Lung Cancer - Memorial Sloan Kettering Cancer Center
Posted: June 1st, 2016, 5:00am GMT
Combination Immunotherapy Shows New Promise for Lung Cancer Memorial Sloan Kettering Cancer CenterImmunotherapy has emerged as a promising new treatment option for people with lung cancer. MSK scientists are conducting research to enable more patients ...
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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #25: Insulin Gene Expression and Biosynthesis Part 1 of 6 - Diabetes In Control
Posted: May 24th, 2016, 5:00am GMT
International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #25: Insulin Gene Expression and Biosynthesis Part 1 of 6 Diabetes In ControlIntroduction. The unique property of the pancreatic β cell is its ability to secrete insulin to enable circulating glucose levels to be maintained within a narrow ...
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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #17: Development and Maintenance of the Islet Beta Cell Part 1 of 4 - Diabetes In Control
Posted: March 29th, 2016, 5:00am GMT
International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #17: Development and Maintenance of the Islet Beta Cell Part 1 of 4 Diabetes In ControlIntroduction. The discovery of insulin by Banting and Best in the early 1920s marked the beginning of a new era of diabetes research that focused on the study of ...
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Ground-Glass Opacity Lung Nodules in the Era of Lung Cancer CT Screening: Radiology, Pathology, and Clinical Management - Cancer Network
Posted: March 16th, 2016, 5:00am GMT
Ground-Glass Opacity Lung Nodules in the Era of Lung Cancer CT Screening: Radiology, Pathology, and Clinical Management Cancer NetworkThis review focuses on the radiologic and pathologic features of ground-glass opacity nodules, along with the clinical management of these lesions.
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Ground-Glass Opacity Lung Nodules in the Era of Lung Cancer CT Screening: Radiology, Pathology, and Clinical Management - Cancer Network
Posted: March 16th, 2016, 5:00am GMT
Ground-Glass Opacity Lung Nodules in the Era of Lung Cancer CT Screening: Radiology, Pathology, and Clinical Management Cancer NetworkThis review focuses on the radiologic and pathologic features of ground-glass opacity nodules, along with the clinical management of these lesions.
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Genomic Analysis Yields Four Subtypes of Pancreatic Cancer - Cancer Network
Posted: March 9th, 2016, 6:00am GMT
Genomic Analysis Yields Four Subtypes of Pancreatic Cancer Cancer NetworkAn integrated genomic analysis has found that pancreatic cancer can be divided into four specific subtypes based on molecular characteristics. This division ...
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PNA lectin for purifying mouse acinar cells from the inflamed pancreas - Nature.com
Posted: February 17th, 2016, 6:00am GMT
PNA lectin for purifying mouse acinar cells from the inflamed pancreas Nature.comBetter methods for purifying human or mouse acinar cells without the need for genetic modification are needed. Such techniques would be advantageous for the ...
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Immediate Repeat Prostate Biopsy May Be Unnecessary in Most ASAP Cases - Renal and Urology News
Posted: November 19th, 2015, 6:00am GMT
Immediate Repeat Prostate Biopsy May Be Unnecessary in Most ASAP Cases Renal and Urology NewsRelatively few men with atypical small acinar proliferation are found to have high-grade prostate cancer on repeat biopsy.
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Immediate Repeat Prostate Biopsy May Be Unnecessary in Most ASAP Cases - Renal and Urology News
Posted: November 19th, 2015, 6:00am GMT
Immediate Repeat Prostate Biopsy May Be Unnecessary in Most ASAP Cases Renal and Urology NewsRelatively few men with atypical small acinar proliferation are found to have high-grade prostate cancer on repeat biopsy.
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Aggressive Lung Adenocarcinoma Subtype May Require New Treatment Strategy - Memorial Sloan Kettering Cancer Center
Posted: September 17th, 2015, 5:00am GMT
Aggressive Lung Adenocarcinoma Subtype May Require New Treatment Strategy Memorial Sloan Kettering Cancer CenterDoctors are now able to identify whether patients with early-stage lung adenocarcinoma have an aggressive form called solid predominant subtype. Following ...
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Aggressive Lung Adenocarcinoma Subtype May Require New Treatment Strategy - Memorial Sloan Kettering Cancer Center
Posted: September 17th, 2015, 5:00am GMT
Aggressive Lung Adenocarcinoma Subtype May Require New Treatment Strategy Memorial Sloan Kettering Cancer CenterDoctors are now able to identify whether patients with early-stage lung adenocarcinoma have an aggressive form called solid predominant subtype. Following ...
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Histologic Classification Could Aid Prognosis in Lung Adenocarcinoma - Cancer Network
Posted: August 11th, 2015, 5:00am GMT
Histologic Classification Could Aid Prognosis in Lung Adenocarcinoma Cancer NetworkNew classification guidelines for histologic subtypes of stage I lung adenocarcinoma offer prognostic value, according to a recent study.
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Histologic Classification Could Aid Prognosis in Lung Adenocarcinoma - Cancer Network
Posted: August 11th, 2015, 5:00am GMT
Histologic Classification Could Aid Prognosis in Lung Adenocarcinoma Cancer NetworkNew classification guidelines for histologic subtypes of stage I lung adenocarcinoma offer prognostic value, according to a recent study.
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Heat-shock factor 2 is a suppressor of prostate cancer invasion - Nature.com
Posted: June 29th, 2015, 5:00am GMT
Heat-shock factor 2 is a suppressor of prostate cancer invasion Nature.comHeat-shock factors (HSFs) are key transcriptional regulators in cell survival. Although HSF1 has been identified as a driver of carcinogenesis, HSF2 has not ...
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Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers - Nature.com
Posted: June 15th, 2015, 5:00am GMT
Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers Nature.comDifferentiated epithelial structure communicates with individual constituent epithelial cells to suppress their proliferation activity. However, the pathways linking ...
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Imaging of Secreted Extracellular Periostin, an Important Marker of Invasion in the Tumor Microenvironment in Esophageal Cancer - Journal of Nuclear Medicine
Posted: June 11th, 2015, 5:00am GMT
Imaging of Secreted Extracellular Periostin, an Important Marker of Invasion in the Tumor Microenvironment in Esophageal Cancer Journal of Nuclear Medicine+ Author Affiliations. 1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts.
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Role of α1 and α2 chains of type IV collagen in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts - Nature.com
Posted: May 25th, 2015, 5:00am GMT
Role of α1 and α2 chains of type IV collagen in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts Nature.comEarly fibrotic lesions are thought to be the initial findings of fibrogenesis in idiopathic interstitial pneumonias, but little is known about their properties. Type IV ...
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Chad Scott Strawn - Coos Bay World
Posted: April 25th, 2015, 5:00am GMT
Chad Scott Strawn Coos Bay WorldChad was born on Dec. 13, 1966, to Darrell and Joyce Strawn in Coos Bay, Ore. He spent his childhood in North Bend, Ore., with family and Grandparents, ...
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Chad Scott Strawn - Coos Bay World
Posted: April 25th, 2015, 5:00am GMT
Chad Scott Strawn Coos Bay WorldChad was born on Dec. 13, 1966, to Darrell and Joyce Strawn in Coos Bay, Ore. He spent his childhood in North Bend, Ore., with family and Grandparents, ...
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How does prostate cancer form? Parkinson's Link? - Science Daily
Posted: December 18th, 2014, 6:00am GMT
How does prostate cancer form? Parkinson's Link? Science DailyThe cause of prostate cancer may be linked to Parkinson's disease through a common enzyme family called sirtuins. Finding an enzyme that regulates this ...
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Low Testosterone May Indicate Prostate Cancer Progression - Cancer Network
Posted: May 8th, 2014, 5:00am GMT
Low Testosterone May Indicate Prostate Cancer Progression Cancer NetworkLow testosterone levels may indicate disease worsening in men diagnosed with low-risk prostate cancer who are being evaluated by active surveillance, ...
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“To Serve and Protect”: Enzyme Inhibitors as Radiopeptide Escorts Promote Tumor Targeting - Journal of Nuclear Medicine
Posted: November 28th, 2013, 6:00am GMT
“To Serve and Protect”: Enzyme Inhibitors as Radiopeptide Escorts Promote Tumor Targeting Journal of Nuclear Medicine+ Author Affiliations. 1Molecular Radiopharmacy, INRASTES, National Center for Scientific Research “Demokritos,” Athens, Greece. 2Department of Nuclear ...
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Newport's Andrew Rodman -- surfer, poet and editor -- reaches into his beliefs to beat back cancer on his own terms - OregonLive.com
Posted: November 29th, 2011, 6:00am GMT
Newport's Andrew Rodman -- surfer, poet and editor -- reaches into his beliefs to beat back cancer on his own terms OregonLive.comRodman, well known on Oregon's central coast as a poet, artist, surfer and editor of the magazine "In Good Tilth," drew on his knowledge of the organic world to ...
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Newport's Andrew Rodman -- surfer, poet and editor -- reaches into his beliefs to beat back cancer on his own terms - OregonLive.com
Posted: November 29th, 2011, 6:00am GMT
Newport's Andrew Rodman -- surfer, poet and editor -- reaches into his beliefs to beat back cancer on his own terms OregonLive.comRodman, well known on Oregon's central coast as a poet, artist, surfer and editor of the magazine "In Good Tilth," drew on his knowledge of the organic world to ...
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Monitoring of Gustatory Stimulation of Salivary Glands by Diffusion-Weighted MR Imaging: Comparison of 1.5T and 3T - AJNR (subscription)
Posted: September 30th, 2011, 9:57am GMT
Monitoring of Gustatory Stimulation of Salivary Glands by Diffusion-Weighted MR Imaging: Comparison of 1.5T and 3T AJNR (subscription)C.R. Habermann, P. Gossrau, H. Kooijman, J. Graessner, M.C. Cramer, M.G. Kaul, F. Reitmeier, M. Jaehne and G. Adam. American Journal of Neuroradiology ...
PubMed - Acinar Cell Carcinoma
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Strong triaxial coupling and anomalous Poisson effect in collagen networks.
Fetched: May 23rd, 2019, 5:00am GMT
Related Articles Strong triaxial coupling and anomalous Poisson effect in collagen networks.
Proc Natl Acad Sci U S A. 2019 04 02;116(14):6790-6799
Authors: Ban E, Wang H, Franklin JM, Liphardt JT, Janmey PA, Shenoy VB
Abstract
While cells within tissues generate and sense 3D states of strain, the current understanding of the mechanics of fibrous extracellular matrices (ECMs) stems mainly from uniaxial, biaxial, and shear tests. Here, we demonstrate that the multiaxial deformations of fiber networks in 3D cannot be inferred solely based on these tests. The interdependence of the three principal strains gives rise to anomalous ratios of biaxial to uniaxial stiffness between 8 and 9 and apparent Poisson's ratios larger than 1. These observations are explained using a microstructural network model and a coarse-grained constitutive framework that predicts the network Poisson effect and stress-strain responses in uniaxial, biaxial, and triaxial modes of deformation as a function of the microstructural properties of the network, including fiber mechanics and pore size of the network. Using this theoretical approach, we found that accounting for the Poisson effect leads to a 100-fold increase in the perceived elastic stiffness of thin collagen samples in extension tests, reconciling the seemingly disparate measurements of the stiffness of collagen networks using different methods. We applied our framework to study the formation of fiber tracts induced by cellular forces. In vitro experiments with low-density networks showed that the anomalous Poisson effect facilitates higher densification of fibrous tracts, associated with the invasion of cancerous acinar cells. The approach developed here can be used to model the evolving mechanics of ECM during cancer invasion and fibrosis.
PMID: 30894480 [PubMed - indexed for MEDLINE]
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Epidermal growth factor receptor and anaplastic lymphoma kinase mutation in adenocarcinoma lung: Their incidence and correlation with histologic patterns.
Fetched: May 23rd, 2019, 5:00am GMT
Related Articles Epidermal growth factor receptor and anaplastic lymphoma kinase mutation in adenocarcinoma lung: Their incidence and correlation with histologic patterns.
Indian J Pathol Microbiol. 2019 Jan-Mar;62(1):24-30
Authors: Gupta P, Gowrishankar S, Swain M
Abstract
Introduction: Epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutational analysis in adenocarcinoma lung are growing in importance as these tests are essential in guiding the use of targeted therapy. However, the prevalence of these mutations in various populations in India has not been studied. Furthermore, the correlation of histologic pattern with the mutation is not clear.
Materials and Methods: A total of 64 biopsy-proven lung adenocarcinomas were selected. In 51 of these, EGFR mutational analysis was performed using Qiagen EGFR pyrosequencing kit and in 56 cases of these ALK1 immunohistochemistry (IHC) was done using ALK (D5F3) antibody and the Ventana Benchmark® XT automated IHC slide staining system for the detection of overexpression. The adenocarcinomas were classified into well, moderate, and poorly differentiated, and the histological pattern was recorded according to the WHO 2014 classification.
Results: EGFR mutation was positive in 23 cases (45.10%) and positive ALK1 expression by IHC in 12 cases (21.43%). Both mutations were positive in two cases. Both mutations were seen in well-differentiated and moderately differentiated adenocarcinoma, and the expression was highest in tumors with a predominant acinar pattern.
Conclusions: The incidence of both EGFR and ALK1 mutations is higher in the population studied and seem to correlate with a well differentiated, acinar pattern on morphology.
PMID: 30706855 [PubMed - indexed for MEDLINE]
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Effect of microRNA-27a-5p on apoptosis and inflammatory response of pancreatic acinar cells in acute pancreatitis by targeting PTEN.
Fetched: May 22nd, 2019, 5:00am GMT
Related Articles Effect of microRNA-27a-5p on apoptosis and inflammatory response of pancreatic acinar cells in acute pancreatitis by targeting PTEN.
J Cell Biochem. 2019 May 20;:
Authors: Kong L, Wu Q, Zhao L, Ye J, Li N, Yang H
Abstract
To investigate the apoptosis and inflammatory response of microRNA-27a-5p (miR-27a-5p) in pancreatic acinar cells of acute pancreatitis (AP) and its related mechanisms. Rat pancreatic acinar cell line AR42J was treated with caerulein (10nmol/L) to construct an acute pancreatitis cell model. Quantitative real-time polymerase chain reaction was performed to measure the expression of miR-27a-5p; The miR-27a-5p mimic was transfected into cell, and the apoptosis rate of the cells was detected by flow cytometry; The levels of TNF-α, IL-1, and IL-6 in the culture supernatant were determined by enzyme-linked immunosorbent assay; TargetScans database predicted and dual luciferase reporter gene assay verified the relationship between miR-27a-5p and the phosphatase and tensin homolog deleted on chromosome 10 (PTEN); The recovery experiment explored the apoptosis and the effects of inflammatory responses. The expression of miR-27a-5p decreased gradually (P < 0.05) and the expression of PTEN increased gradually (P < 0.05) with the prolongation of acting time. Upregulation of miR-27a-5p significantly promoted cell apoptosis (P < 0.05) and inhibited inflammatory response (P < 0.05); The TargetScans database predicted that the 3'UTR of PTEN contains a base complementary to the miR-27a-5p seed region. Cotransfection of wild-type vector (PTEN-WT) with miR-27a-5p mimic or miR-27a-5p inhibitor significantly affected the relative activity of luciferase (P < 0.05), and no significant impact was observed in mutant PTEN-MUT. Compared with miR-27a-5p + pcDNA group, transfection of miR-27a-5p mimic and pcDNA-PTEN significantly increased the expression of PTEN (P < 0.05), decreased the apoptotic rate (P < 0.05), and increased the inflammatory response (P < 0.05). miR-27a-5p induced apoptosis and inhibited the inflammatory response of pancreatic acinar cells in AP by targeting PTEN.
PMID: 31106896 [PubMed - as supplied by publisher]
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Albumin In Situ Hybridization Can Be Positive in Adenocarcinomas and Other Tumors From Diverse Sites.
Fetched: May 22nd, 2019, 5:00am GMT
Related Articles Albumin In Situ Hybridization Can Be Positive in Adenocarcinomas and Other Tumors From Diverse Sites.
Am J Clin Pathol. 2019 May 20;:
Authors: Nasir A, Lehrke HD, Mounajjed T, Said S, Zhang L, Yasir S, Shah SS, Chandan VS, Smyrk TC, Moreira RK, Boland Froemming JM, Herrera Hernandez LP, Wu TT, Graham RP
Abstract
OBJECTIVES: Albumin messenger RNA (mRNA) expression is a marker of hepatocellular differentiation. Most published data are from review of tissue microarrays, and albumin in situ hybridization (ISH) expression across several tumor types is incompletely characterized.
METHODS: Sections from 221 tumors were evaluated for albumin mRNA. Immunohistochemistry was used to confirm diagnoses. Albumin ISH was performed according to manufacturer-provided instructions. Fifty-nine cases were evaluated with both commercial ISH assays.
RESULTS: Albumin mRNA was detected in all hepatocellular carcinomas (HCCs) and 81% of intrahepatic cholangiocarcinomas. Lung (20%), gallbladder (39%), hepatoid pancreatic (n = 1 of 1) adenocarcinoma, breast invasive ductal carcinoma (18%), yolk sac tumor (25%), and acinar cell carcinoma (29%) showed expression. Both assays were concordant in 93% of cases.
CONCLUSIONS: Albumin ISH was expressed in all HCCs studied. It was also positive in intrahepatic cholangiocarcinoma and patchy positive in gallbladder adenocarcinoma and a subset of other neoplasms, which can be a potential pitfall.
PMID: 31107526 [PubMed - as supplied by publisher]
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Positive surgical margins in parotid malignancies: Institutional variation and survival association.
Fetched: May 19th, 2019, 5:00am GMT
Related Articles Positive surgical margins in parotid malignancies: Institutional variation and survival association.
Laryngoscope. 2019 01;129(1):129-137
Authors: Morse E, Fujiwara RJT, Judson B, Prasad ML, Mehra S
Abstract
OBJECTIVES/HYPOTHESIS: To establish benchmarks for positive margin incidence in parotid cancers, associate positive margin status with patient, tumor, and institutional factors and overall survival, and characterize institutional variation in positive margin incidence.
STUDY DESIGN: Retrospective database analysis.
METHODS: We identified patients surgically treated for a parotid malignancy 2004 to 2013 in the National Cancer Database. We associated positive margins with patient, tumor, and treatment factors by multivariable logistic regression and with overall survival by Cox proportional hazards regression. We characterized institutional variation in positive margin rates by facility type and volume.
RESULTS: A total of 5,639 patients were identified. The overall positive margin rate was 31%. By institution, positive margin rates varied from 0% to 100%, with a median rate of 31% (interquartile range = 18%-43%). Adenoid cystic carcinoma was associated with increased, and low-grade mucoepidermoid carcinoma with decreased, odds of positive margins, (odds ratio [OR] = 1.91 [95% confidence interval {CI}: 1.54-2.38], P < .001 and OR = 0.68 [95% CI: 0.53-0.87], P = .002, respectively). Treatment at academic or high-volume facilities was associated with decreased odds of positive margins (OR = 0.79 [95% CI: 0.68-0.91], P = .001 and OR = 0.76 [95% CI: 0.63-0.91], P = .004). Positive surgical margins were associated with decreased overall survival (62% vs. 79% 5-year overall survival, hazard ratio [HR] = 1.34 [95% CI: 1.20-1.49], P < .001). Upon stratification by histology, this association was maintained for high-grade, but not low-grade, mucoepidermoid carcinoma (52% vs. 74%, HR = 1.56 [95% CI: 1.31-1.86], P < .001 and 89% versus 91%, HR = 1.05 [95% CI: 0.60-1.83], P = .874, respectively).
CONCLUSIONS: Tumor and institutional factors are associated with positive surgical margins. Positive margin rates vary substantially between facilities and are less likely at academic and high-volume facilities. Positive surgical margins are associated with decreased overall survival and could be considered quality indicators in parotid malignancies.
LEVEL OF EVIDENCE: 2c Laryngoscope, 129:129-137, 2019.
PMID: 30194762 [PubMed - indexed for MEDLINE]
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INSM1 Expression in Primary and Metastatic Neuroendocrine Neoplasms of the Gastrointestinal and Pancreatobiliary Tracts.
Fetched: May 13th, 2019, 5:00am GMT
Related Articles INSM1 Expression in Primary and Metastatic Neuroendocrine Neoplasms of the Gastrointestinal and Pancreatobiliary Tracts.
Histopathology. 2019 May 11;:
Authors: González I, Lu HC, Sninsky J, Yang C, Bishnupuri K, Dieckgraefe B, Cao D, Chatterjee D
Abstract
AIMS: Insulinoma associated protein 1 (INSM1) is a transcription factor expressed in developing and mature neuroendocrine tissue. Recent studies have demonstrated INSM1 as a sensitive marker for neuroendocrine tumors. In this study we evaluate the expression of INSM1 in primary gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) and in their known metastases, in order to assess its sensitivity compared to chromogranin-A (CgA) and synaptophysin (SYN), and to evaluate for any change in expression between primary and metastatic disease.
METHODS AND RESULTS: We identified 30 patients with primary GEP-NEN. In 26 patients their liver metastatic tissue was available; two patients had two metachronous metastatic foci, yielding a total of 28 metastatic cases. Additional 2 and 7 non-paired cases of primary and metastatic grade-3 GEP-NEN respectively, were included. To evaluate for specificity, we evaluated the expression of these markers in other primary tumors (colorectal adenocarcinoma, acinar cell carcinoma, solid pseudopapillary neoplasm, cholangiocarcinoma, and hepatocellular carcinoma) and metastatic tumors in the liver (adrenal cortical, breast and prostate carcinomas) which may arise as a differential diagnoses. In our cohort, all the primary and 94% of the metastatic GEP-NEN expressed INSM1. INSM1 showed similar sensitivity to SYN and higher sensitivity compared to CgA, in both primary and metastatic neoplasms. INSM1 has comparable specificity to CgA, and higher than SYN.
CONCLUSIONS: The nuclear reactivity and the high sensitivity and specificity of INSM1 make it a preferred neuroendocrine marker. In conclusion, INSM1 can be used as a single first line marker for primary and metastatic GEP-NEN. This article is protected by copyright. All rights reserved.
PMID: 31077609 [PubMed - as supplied by publisher]
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Pancreatic Ductal Adenocarcinoma Development in the Remnant Pancreas after Pancreaticoduodenectomy for Acinar Cell Carcinoma: A Case Report.
Fetched: May 9th, 2019, 5:00am GMT
Related Articles Pancreatic Ductal Adenocarcinoma Development in the Remnant Pancreas after Pancreaticoduodenectomy for Acinar Cell Carcinoma: A Case Report.
J Nippon Med Sch. 2019 Apr 26;:
Authors: Nishimura S, Utsumi M, Aoki H, Une Y, Kashima H, Kimura Y, Taniguchi F, Arata T, Katsuda K, Tanakaya K, Sato Y
Abstract
We report the case of a pancreatic ductal adenocarcinoma (PDAC) in the remnant pancreas of a 78-year-old man after pancreaticoduodenectomy for acinar cell carcinoma. Acinar cell carcinoma is a relatively rare pancreatic neoplasm. Following the diagnosis of pancreatic carcinoma, subtotal stomach-preserving pancreaticoduodenectomy was performed. The pathological diagnosis was acinar cell carcinoma of the pancreas, disease stage IA, pT1, pN0, M0, without regional lymph node invasion. Twenty-two months after the surgery, cancer antigen 19-9 levels gradually increased, and computed tomography showed 2 solid tumors, approximately 1.1 and 2.1 cm in diameter, respectively, at the site of the remnant pancreas. Endoscopic ultrasound fine-needle aspiration revealed pancreatic ductal adenocarcinoma. The tumor cells were not immunoreactive for trypsin. Both tumors were diagnosed as PDAC of the remnant pancreas. The patient refused treatment with curative resection. Thus, as an alternative treatment, chemoradiotherapy was initiated. However, 28 months after surgery, the patient succumbed to the disease. Because this is an extremely rare case, further cases and studies are needed to understand its pathogenesis.
PMID: 31061255 [PubMed - as supplied by publisher]
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Initial diagnosis of insignificant cancer, high-grade prostatic intraepithelial neoplasia, atypical small acinar proliferation, and negative have the same rate of upgrade to a Gleason score of 7 or higher on repeat prostate biopsy.
Fetched: May 8th, 2019, 5:00am GMT
Related Articles Initial diagnosis of insignificant cancer, high-grade prostatic intraepithelial neoplasia, atypical small acinar proliferation, and negative have the same rate of upgrade to a Gleason score of 7 or higher on repeat prostate biopsy.
Hum Pathol. 2018 09;79:116-121
Authors: Prathibha S, Goyal KG, Zynger DL
Abstract
Extended prostate needle core biopsies are standard of care for the diagnosis of prostatic carcinoma. Subsequent biopsies may be performed for a variety of indications. Knowledge of biopsy characteristics indicating risk for progression may have utility to guide therapeutic management. Prostate needle core biopsies performed between 2008 and 2014 were reviewed. Patients with at least 1 subsequent biopsy were identified. Cases were categorized by worst initial diagnosis. Gleason ≤6 carcinoma was further classified as significant or insignificant with insignificant defined as follows: ≤2 cores with carcinoma, sites with ≤50% carcinoma, and unilateral carcinoma. A total of 329 men underwent repeat biopsies. Gleason ≤6 insignificant carcinoma, high-grade prostatic intraepithelial neoplasia (HGPIN) and/or atypical small acinar proliferation, and negative biopsies had a similar rate of Gleason ≥7 upon repeat biopsy (16%, 17%, 14%; P = .91). Initial biopsy diagnoses of Gleason ≤6 significant carcinoma had a higher rate of Gleason ≥7 on repeat biopsy compared with initial biopsies of Gleason ≤6 insignificant carcinoma (39%, 16%; P = .003). Within initial diagnoses of Gleason ≤6, 1 core compared with more than 1 core positive had a lower rate of Gleason ≥7 on repeat biopsy (17%, 30%), although this difference was not significant (P = .08). An initial biopsy diagnosed as Gleason ≤6 insignificant carcinoma, HGPIN and/or atypical small acinar proliferation, or negative had a similar substantial risk of Gleason ≥7 carcinoma upon subsequent biopsy. Our findings support the continued stratification of Gleason ≤6 and thus the diagnostic workup of all atypical foci to provide an accurate, thorough number of involved cores.
PMID: 29803813 [PubMed - indexed for MEDLINE]
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Acinar-Predominant Pattern Correlates With Poorer Prognosis in Invasive Mucinous Adenocarcinoma of the Lung.
Fetched: May 8th, 2019, 5:00am GMT
Related Articles Acinar-Predominant Pattern Correlates With Poorer Prognosis in Invasive Mucinous Adenocarcinoma of the Lung.
Am J Clin Pathol. 2018 Mar 29;149(5):373-378
Authors: Lin G, Li H, Kuang J, Tang K, Guo Y, Han A, Xie C
Abstract
Objectives: Invasive mucinous adenocarcinoma (IMA) is a variant of lung adenocarcinoma with several growth patterns, such as lepidic acinar and papillary. However, to our knowledge, no study regarding prognostic and clinicopathologic aspects of IMAs with different growth patterns has been reported.
Methods: Of 2,236 patients with primary lung adenocarcinoma, 16 were identified as having lepidic-predominant IMA and 10 as having acinar-predominant IMA. Data regarding the clinicopathologic characteristics, computed tomography (CT) features, and prognosis were collected.
Results: No statistically significant difference was noted in sex, age, smoker proportion, and T classification between both groups. The proportion of lymph node metastasis was significantly higher in acinar-predominant IMA (P = .046). Both groups shared many signs in CT findings. Air bronchogram was a relatively specific sign for lepidic-predominant IMA. Survival analysis showed that acinar-predominant IMA had a poorer prognosis (P = .0294).
Conclusions: Lepidic-predominant and acinar-predominant IMA are two different subtypes of IMA. Acinar-predominant IMA is associated with lymph node metastasis and a poorer prognosis.
PMID: 29538611 [PubMed - indexed for MEDLINE]
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[Primary acinic cell carcinoma in mandible: a case report].
Fetched: May 8th, 2019, 5:00am GMT
Related Articles [Primary acinic cell carcinoma in mandible: a case report].
Hua Xi Kou Qiang Yi Xue Za Zhi. 2018 Oct 01;36(5):573-575
Authors: Kim KJ, Xu QS, Wang C, Li B, Han ZX, Feng ZE
Abstract
Acinic cell carcinoma is a relatively rare salivary gland tumor predominantly occurring in the major glands. Therefore, acinic cell carcinoma rarely occurs in the mandible. In this study, a case of primary acinic cell carcinoma of the mandible was reported, and relevant literature was reviewed. The etiology, clinical symptom, image and histological features, diagnosis, treatment, and prognosis of acinic cell carcinoma in the mandible were discussed.
PMID: 30465355 [PubMed - indexed for MEDLINE]
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The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice.
Fetched: May 1st, 2019, 5:00am GMT
Related Articles The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice.
Cell Mol Gastroenterol Hepatol. 2019;7(1):93-113
Authors: Young CC, Baker RM, Howlett CJ, Hryciw T, Herman JE, Higgs D, Gibbons R, Crawford H, Brown A, Pin CL
Abstract
Background: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in North America, accounting for >30,000 deaths annually. Although somatic activating mutations in KRAS appear in 97% of PDAC patients, additional factors are required to initiate PDAC. Because mutations in genes encoding chromatin remodelling proteins have been implicated in KRAS-mediated PDAC, we investigated whether loss of chromatin remodeler ɑ-thalassemia, mental-retardation, X-linked (ATRX) affects oncogenic KRAS's ability to promote PDAC. ATRX affects DNA replication, repair, and gene expression and is implicated in other cancers including glioblastomas and pancreatic neuroendocrine tumors. The hypothesis was that deletion of Atrx in pancreatic acinar cells will increase susceptibility to injury and oncogenic KRAS.
Methods: Mice allowing conditional loss of Atrx within pancreatic acinar cells were examined after induction of recurrent cerulein-induced pancreatitis or oncogenic KRAS (KRAS G12D ). Histologic, biochemical, and molecular analysis examined pancreatic pathologies up to 2 months after induction of Atrx deletion.
Results: Mice lacking Atrx showed more progressive damage, inflammation, and acinar-to-duct cell metaplasia in response to injury relative to wild-type mice. In combination with KRASG12D, Atrx-deficient acinar cells showed increased fibrosis, inflammation, progression to acinar-to-duct cell metaplasia, and pre-cancerous lesions relative to mice expressing only KRASG12D. This sensitivity appears only in female mice, mimicking a significant prevalence of ATRX mutations in human female PDAC patients.
Conclusions: Our results indicate the absence of ATRX increases sensitivity to injury and oncogenic KRAS only in female mice. This is an instance of a sex-specific mutation that enhances oncogenic KRAS's ability to promote pancreatic intraepithelial lesion formation.
PMID: 30510993 [PubMed - indexed for MEDLINE]
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ERG oncoprotein expression in prostatic acinar adenocarcinoma; clinicopathologic significance.
Fetched: May 1st, 2019, 5:00am GMT
Related Articles ERG oncoprotein expression in prostatic acinar adenocarcinoma; clinicopathologic significance.
BMC Res Notes. 2019 Jan 18;12(1):35
Authors: Hashmi AA, Khan EY, Irfan M, Ali R, Asif H, Naeem M, Nisar L, Faridi N, Khan A, Edhi MM
Abstract
OBJECTIVES: T/E fusion results in constitutive expression of ERG oncoprotein resulting in enhanced proliferation and invasive potential of prostatic cancer cells. In the present study we aimed to evaluate the ERG overexpression in 78 cases prostate acinar adenocarcinoma and its association with other prognostic parameters.
RESULTS: ERG protein expression was noted in 39.7% (31 cases), out of which 3 cases (3.8%) showed low ERG expression, 10 cases (12.8%) showed intermediate expression and 18 cases (23.1%) revealed high ERG expression. Significant association of ERG expression was noted with gleason score (p = 0.009), WHO grade group (p = 0.008) and perineural invasion (p = 0.043). We found a significant proportion of our patients of prostatic acinar adenocarcinoma to over-express ERG protein which can help in devising therapeutic protocols. Significant association of ERG protein expression with gleason score and perineural invasion signifies its prognostic significance in prostatic carcinoma. Moreover, we also suggest that molecular studies should be performed in patients with prostatic carcinoma to look for T/E fusion gene and its correlation with ERG protein expression.
PMID: 30658688 [PubMed - indexed for MEDLINE]
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Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.
Fetched: April 28th, 2019, 5:00am GMT
Related Articles Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.
Gut. 2019 05;68(5):882-892
Authors: Ikuta K, Fukuda A, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Tsuda M, Kimura Y, Matsumoto Y, Kimura Y, Maruno T, Kanda K, Nishi K, Takaori K, Uemoto S, Takaishi S, Chiba T, Nishi E, Seno H
Abstract
OBJECTIVE: Nardilysin (NRDC), a zinc peptidase, exhibits multiple localisation-dependent functions including as an enhancer of ectodomain shedding in the extracellular space and a transcriptional coregulator in the nucleus. In this study, we investigated its functional role in exocrine pancreatic development, homeostasis and the formation of pancreatic ductal adenocarcinoma (PDA).
DESIGN: We analysed Ptf1a-Cre; Nrdcflox/flox mice to investigate the impact of Nrdc deletion. Pancreatic acinar cells were isolated from Nrdcflox/flox mice and infected with adenovirus expressing Cre recombinase to examine the impact of Nrdc inactivation. Global gene expression in Nrdc-cKO pancreas was analysed compared with wild-type pancreas by microarray analysis. We also analysed Ptf1a-Cre; KrasG12D; Nrdcflox/flox mice to investigate the impact of Nrdc deletion in the context of oncogenic Kras. A total of 51 human samples of pancreatic intraepithelial lesions (PanIN) and PDA were examined by immunohistochemistry for NRDC.
RESULTS: We found that pancreatic deletion of Nrdc leads to spontaneous chronic pancreatitis concomitant with acinar-to-ductal conversion, increased apoptosis and atrophic pancreas in mice. Acinar-to-ductal conversion was observed mainly through a non-cell autonomous mechanism, and the expression of several chemokines was significantly increased in Nrdc-null pancreatic acinar cells. Furthermore, pancreatic deletion of Nrdc dramatically accelerated KrasG12D -driven PanIN and subsequent PDA formation in mice. These data demonstrate a previously unappreciated anti-inflammatory and tumour suppressive functions of Nrdc in the pancreas in mice. Finally, absence of NRDC expression was observed in a subset of human PanIN and PDA.
CONCLUSION: Nrdc inhibits pancreatitis and suppresses PDA initiation in mice.
PMID: 29798841 [PubMed - indexed for MEDLINE]
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Inconsistency Between Contrast-Enhanced CT and Bone Scintigraphy in Revealing Radiation Nephritis.
Fetched: April 27th, 2019, 5:00am GMT
Related Articles Inconsistency Between Contrast-Enhanced CT and Bone Scintigraphy in Revealing Radiation Nephritis.
Clin Nucl Med. 2019 Apr 19;:
Authors: Zhu W, Zhen H, Ding N, Jing H, Huo L
Abstract
A 34-year-old woman with pancreatic acinar cell carcinoma underwent a Tc-MDP bone scan to rule out potential bone metastasis because of back pain 18 months after radiation therapy. The bone scintigraphy revealed increased uptake over the upper pole of both kidneys corresponding to the portions of the kidneys included within the radiation field, consisting with radiation nephritis.
PMID: 31021909 [PubMed - as supplied by publisher]
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Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer.
Fetched: April 25th, 2019, 5:00am GMT
Related Articles Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer.
Mol Ther Oncolytics. 2019 Sep 27;14:57-65
Authors: Nair RP, Timiri Shanmugam PS, Sunavala-Dossabhoy G
Abstract
Oral radiotoxicity is often a limiting factor in cancer treatment. Previously, we demonstrated that transfer of cell-permeable, TAT-fusion Tousled-like kinase 1B (TLK1B) protein in salivary glands effectively mitigates radiation-induced salivary dysfunction. However, similar to most radioprotectors, TLK1B can carry the risk of limiting cancer treatment efficacy. The central goal of the study was, therefore, to reengineer TLK1B as a selective radioprotector of normal cells. Degradation of the extracellular matrix by proteases such as matrix metalloproteinases (MMPs) is a hallmark of aggressive tumors. Increased expression of membrane type 1-MMP (MT1-MMP; also called MMP14) is observed in a variety of cancers including head and neck squamous cell carcinoma (HNSCC). To limit TLK1B transduction to normal cells, we rendered the protein susceptible to MT1-MMP cleavage on the premise that high expression of MT1-MMP on the cell surface of HNSCC will suppress TLK1B internalization. Two optimal MT1-MMP-sensitive sequences (MS) were identified that when incorporated in TAT-TLK1B excluded its cellular entry in HNSCC, SCC40, but not immortalized salivary acinar cells, NS-SV-AC. Importantly, administration of MS-harboring TAT-TLK1B did not affect the sensitivity of tumors to radiation in a nude mouse xenograft tumor model. We conclude that a MMP-sensitive TLK1B can be an attractive therapeutic to allay salivary radiotoxicity without compromising cancer treatment efficacy.
PMID: 31011632 [PubMed]
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Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review.
Fetched: April 21st, 2019, 5:00am GMT
Related Articles Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review.
Cancer Biol Ther. 2019 Apr 19;:1-7
Authors: Kryklyva V, Haj Mohammad N, Morsink FHM, Ligtenberg MJL, Offerhaus GJA, Nagtegaal ID, de Leng WWJ, Brosens LAA
Abstract
Acinar cell carcinoma (ACC) is a rare pancreatic neoplasm with dismal prognosis. Insights into the molecular basis of ACC can pave the way for the application of more effective, personalized therapies and detection of patients with hereditary predisposition. Molecular analysis revealed a germline BRCA2 (and CHEK2) mutation in a patient with a rare pancreatic ACC with extensive intraductal growth. Somatic loss of the wild-type BRCA2 allele in the tumor indicated the causal relationship of ACC with the germline defect. A thorough literature review identified another nine ACCs associated with germline BRCA2 mutation and two ACCs associated with germline BRCA1 mutation, resulting in a prevalence of BRCA1/2 germline mutations in almost 7% of ACCs. Moreover, somatic BRCA1/2 alterations are reported in 16% of sporadic ACCs. Overall, about one fifth (22%) of all pancreatic ACCs exhibit BRCA1/2 deficiency. This study underscores the important role of BRCA1/2 mutations in pancreatic ACC. All ACC patients should undergo genetic testing for BRCA1/2 mutations to identify carriers of pathogenic variants. This will allow to select patients that can benefit from targeted therapies directed against BRCA1/2-deficient tumors and is also crucial as a referral to genetic screening for the relatives of affected individuals carrying germline BRCA1/2 alterations. Abbreviations: ACC: acinar cell carcinoma; HBOC: Hereditary Breast and Ovarian Cancer; LOH: loss of heterozygosity; PARP: poly (ADP-ribose) polymerase; PDAC: pancreatic ductal adenocarcinoma; PP: pancreatic panniculitis; SD: standard deviation; WES: whole-exome sequencing.
PMID: 31002019 [PubMed - as supplied by publisher]