The frontline combination of ibrutinib (Imbruvica) and nab-paclitaxel (Abraxane)/gemcitabine did not show a statistically significant benefit in progression-free or ...
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Google - Acinar Cell Carcinoma
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Ibrutinib Combo Falls Short in Pancreatic Cancer - OncLive
Posted: January 22nd, 2019, 2:06pm GMT
Ibrutinib Combo Falls Short in Pancreatic Cancer OncLive -
No Survival Improvement Seen With Ibrutinib Combination in Pancreatic Cancer - Targeted Oncology
Posted: January 22nd, 2019, 6:00am GMT
No Survival Improvement Seen With Ibrutinib Combination in Pancreatic Cancer Targeted OncologyFrontline treatment with ibrutinib plus nab-paclitaxel/gemcitabine did not have a statistically significant benefit in progression-free survival or overall survival ...
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Grantee Studies Cellular Changes to Stop Pancreatic Cancer Tumors - Pancreatic Cancer News & Stories
Posted: January 15th, 2019, 6:00am GMT
Grantee Studies Cellular Changes to Stop Pancreatic Cancer Tumors Pancreatic Cancer News & StoriesRecently published in Cancer Discovery, PanCAN grantee Kathryn Wellen, PhD, describes how blocking changes in cells' ability to break down nutrients could ...
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Surgery unnecessary for many prostate cancer patients - Medical Xpress
Posted: December 13th, 2018, 6:00am GMT
Surgery unnecessary for many prostate cancer patients Medical XpressOtherwise healthy men with advanced prostate cancer may benefit greatly from surgery, but many with this diagnosis have no need for it. These conclusions ...
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Pulling the genome apart: Chromosome segregation during mitosis explained - Phys.org
Posted: November 13th, 2018, 6:00am GMT
Pulling the genome apart: Chromosome segregation during mitosis explained Phys.orgWhen a cell divides—a process known as mitosis—its chromosomes need to be separated and evenly distributed into the newly created daughter cells.
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Efficacy, effectiveness, and safety of herpes zoster vaccines in adults aged 50 and older: systematic review and network meta-analysis - The BMJ
Posted: October 25th, 2018, 5:00am GMT
Efficacy, effectiveness, and safety of herpes zoster vaccines in adults aged 50 and older: systematic review and network meta-analysis The BMJBMJ 2018; 363 doi: [https:] (Published 25 October 2018) Cite this as: BMJ 2018;363:k4029. Linked Editorial. Which shingles vaccine ...
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New kind of compound shows early promise against prostate cancer - Medical Xpress
Posted: October 23rd, 2018, 5:00am GMT
New kind of compound shows early promise against prostate cancer Medical XpressA new type of molecule blocks the action of genes that drive the growth of therapy-resistant prostate cancer, a new study finds.
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Nanoparticle therapeutic restores function of tumor suppressor in prostate cancer - Medical Xpress
Posted: September 17th, 2018, 5:00am GMT
Nanoparticle therapeutic restores function of tumor suppressor in prostate cancer Medical XpressThink of it as a cancer therapy zag instead of a zig. While many groups are developing cancer therapies to target proteins and pathways that are highly active in ...
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Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis - Journal of Virology
Posted: August 28th, 2018, 11:00am GMT
Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis Journal of VirologyViral myocarditis, which is most prevalently caused by coxsackievirus B3 (CVB3), is a serious clinical condition characterized by excessive myocardial ...
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Phosphatidylinositol Biphosphate (PIP2) Signal Pathway - News-Medical.net
Posted: August 23rd, 2018, 5:00am GMT
Phosphatidylinositol Biphosphate (PIP2) Signal Pathway News-Medical.netBy Jeyashree Sundaram, MBA. Phosphatidylinositol 4,5-bisphosphate (PIP2) is an essential lipid involved in metabolic processes. It is integral to the cell ...
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Microcalcifications in Breast Cancer - News-Medical.net
Posted: August 2nd, 2018, 1:21am GMT
Microcalcifications in Breast Cancer News-Medical.netCalcifications in the breast can be benign or malignant. They can appear as either macrocalcifications or microcalcifications on a mammogram (i.e. an X-ray of ...
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Discovering the mechanisms that underlie prostate cancer - Medical Xpress
Posted: July 12th, 2018, 5:00am GMT
Discovering the mechanisms that underlie prostate cancer Medical XpressNew research has uncovered insights into the mechanisms that underlie prostate cancer, providing potential targets for new cancer therapies.
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Acinic Cell Carcinoma - News-Medical.net
Posted: June 20th, 2018, 11:29pm GMT
Acinic Cell Carcinoma News-Medical.netAs salivary glands are made up of different cells, tumors could start in any one of such. Various salivary gland tumors, which may be benign or malignant, may ...
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Fewer men are being screened, diagnosed, and treated for prostate cancer - Medical Xpress
Posted: May 21st, 2018, 5:00am GMT
Fewer men are being screened, diagnosed, and treated for prostate cancer Medical XpressA new study reveals declines in prostate cancer screening and diagnoses in the United States in recent years, as well as decreases in the use of definitive ...
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LI scientist paves the way for halting pancreatic cancer's spread - Newsday
Posted: May 17th, 2018, 5:00am GMT
LI scientist paves the way for halting pancreatic cancer's spread NewsdayOn Wednesday, Dr. Douglas Fearon, a scientist at Cold Spring Harbor Laboratory, discussed his discovery that dormant pancreatic cancer cells are lying in wait ...
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Hydrogel microenvironments for cancer spheroid growth and drug screening - Science Advances
Posted: April 27th, 2018, 5:00am GMT
Hydrogel microenvironments for cancer spheroid growth and drug screening Science AdvancesMulticellular cancer spheroids (MCSs) have emerged as a promising in vitro model that replicates many features of solid tumors in vivo. Biomimetic hydrogel ...
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EGFR+ Non-Small Cell Lung Cancer: Frontline Options - Targeted Oncology
Posted: April 13th, 2018, 5:00am GMT
EGFR+ Non-Small Cell Lung Cancer: Frontline Options Targeted OncologyMark Socinski, MD, shares insight on the frontline systemic therapy options available for EGFR-mutant NSCLC treatment and considers multidisciplinary care in ...
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EGFR+ NSCLC: Treatment Through Multiple Lines of Therapy - Targeted Oncology
Posted: April 13th, 2018, 5:00am GMT
EGFR+ NSCLC: Treatment Through Multiple Lines of Therapy Targeted OncologyMark Socinski, MD, discusses his recommendations if a patient with EGFR-mutant non-small cell lung cancer develops disease progression through multiple ...
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Metabolic profiling may determine aggressiveness, prognosis of prostate cancer - Medical Xpress
Posted: March 26th, 2018, 5:00am GMT
Metabolic profiling may determine aggressiveness, prognosis of prostate cancer Medical XpressA new approach to analyzing prostate gland tissue may help address a major challenge in treating prostate cancer - determining which tumors are unlikely to ...
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TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease - AJP-Lung Physiology (subscription)
Posted: March 13th, 2018, 1:52am GMT
TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease AJP-Lung Physiology (subscription)Epithelial-mesenchymal transition (EMT), a process whereby fully differentiated epithelial cells undergo transition to a mesenchymal phenotype giving rise to ...
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Norwich man trying to raise £70,000 for rare cancer treatment | Health - Norfolk Eastern Daily Press
Posted: February 14th, 2018, 6:00am GMT
Norwich man trying to raise £70,000 for rare cancer treatment | Health Norfolk Eastern Daily PressA father-of-two with terminal cancer and his family are in a desperate race against time to raise £70000 for treatment abroad or face palliative care.
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Cell-cell adhesion in lung endothelium - AJP-Lung Physiology (subscription)
Posted: December 9th, 2017, 1:18pm GMT
Cell-cell adhesion in lung endothelium AJP-Lung Physiology (subscription)Homotypic cell-cell adhesion is essential for tissue and organ development, remodeling, regeneration, and physiological function. Whereas a significant number ...
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Pancreatic cancer: specific protein promotes development of pancreatitis and tumours - Drug Target Review
Posted: December 6th, 2017, 6:00am GMT
Pancreatic cancer: specific protein promotes development of pancreatitis and tumours Drug Target ReviewA study has shown that disruption to cell autophagy is involved in the development of pancreatic cancer.
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Fast Five Quiz: Prostate Cancer - Medscape
Posted: October 15th, 2017, 4:04am GMT
Fast Five Quiz: Prostate Cancer MedscapeProstate cancer is the most common noncutaneous cancer in men and is the second most common cause of cancer deaths. Do you know what to watch for and ...
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Functional Optical Imaging of Primary Human Tumor Organoids: Development of a Personalized Drug Screen - Journal of Nuclear Medicine
Posted: September 1st, 2017, 5:00am GMT
Functional Optical Imaging of Primary Human Tumor Organoids: Development of a Personalized Drug Screen Journal of Nuclear Medicine+ Author Affiliations. 1Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee. 2Department of Cancer Biology, Vanderbilt University ...
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Types of Hematuria - News-Medical.net
Posted: August 3rd, 2017, 11:18am GMT
Types of Hematuria News-Medical.netHematuria is a health condition that is characterized by the presence of blood in the urine. There are two main types of hematuria: microscopic and macroscopic.
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No prescription synthroid - Study of Sports
Posted: May 15th, 2017, 5:00am GMT
No prescription synthroid Study of SportsNo prescription synthroid. Synthroid 40mg, Buy synthroid without prescription. No prescription needed, approved pharmacy. Best Quality and EXTRA LOW ...
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Can Artificial Sweeteners Reduce Pancreatic Cancer Risk? - News-Medical.net
Posted: May 4th, 2017, 5:00am GMT
Can Artificial Sweeteners Reduce Pancreatic Cancer Risk? News-Medical.netPancreatic cancer claims the fourth highest spot on the list of cancer-related mortality, despite the fact that it doesn't even make the top ten for incidence.
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Can Artificial Sweeteners Reduce Pancreatic Cancer Risk? - News-Medical.net
Posted: May 4th, 2017, 5:00am GMT
Can Artificial Sweeteners Reduce Pancreatic Cancer Risk? News-Medical.netPancreatic cancer claims the fourth highest spot on the list of cancer-related mortality, despite the fact that it doesn't even make the top ten for incidence.
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Primary pancreatic lymphoma: two case reports and a literature review | OTT - Dove Medical Press
Posted: March 20th, 2017, 5:00am GMT
Primary pancreatic lymphoma: two case reports and a literature review | OTT Dove Medical PressPrimary pancreatic lymphoma: two case reports and a literature review Lili Yu,1,2,* Yajun Chen,1,2,* Ligang Xing2 1School of Medicine and Life Sciences, ...
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Therapeutic Implications of Molecular Subtyping for Pancreatic Cancer - Cancer Network
Posted: March 15th, 2017, 5:00am GMT
Therapeutic Implications of Molecular Subtyping for Pancreatic Cancer Cancer NetworkIn this article, we review seminal articles that have evaluated the molecular architecture of pancreatic cancer. We compare the methods used and the molecular ...
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Adenosquamous Carcinoma of the Prostate: A Rare Aggressive Tumor with a Review of the Literature - UroToday
Posted: January 31st, 2017, 11:31am GMT
Adenosquamous Carcinoma of the Prostate: A Rare Aggressive Tumor with a Review of the Literature UroTodayABSTRACT. Adenosquamous carcinoma (ASCC) of the prostate is an extremely rare, aggressive neoplasm with only few cases are reported in literature.
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68Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer - Journal of Nuclear Medicine
Posted: June 3rd, 2016, 5:00am GMT
68Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer Journal of Nuclear Medicine+ Author Affiliations. 1Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany. 2Institute for Clinical Radiology, ...
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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #17: Development and Maintenance of the Islet Beta Cell Part 1 of 4 - Diabetes In Control
Posted: March 29th, 2016, 5:00am GMT
International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #17: Development and Maintenance of the Islet Beta Cell Part 1 of 4 Diabetes In ControlIntroduction. The discovery of insulin by Banting and Best in the early 1920s marked the beginning of a new era of diabetes research that focused on the study of ...
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Ground-Glass Opacity Lung Nodules in the Era of Lung Cancer CT Screening: Radiology, Pathology, and Clinical Management - Cancer Network
Posted: March 16th, 2016, 5:00am GMT
Ground-Glass Opacity Lung Nodules in the Era of Lung Cancer CT Screening: Radiology, Pathology, and Clinical Management Cancer NetworkThis review focuses on the radiologic and pathologic features of ground-glass opacity nodules, along with the clinical management of these lesions.
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PNA lectin for purifying mouse acinar cells from the inflamed pancreas - Nature.com
Posted: February 17th, 2016, 6:00am GMT
PNA lectin for purifying mouse acinar cells from the inflamed pancreas Nature.comBetter methods for purifying human or mouse acinar cells without the need for genetic modification are needed. Such techniques would be advantageous for the ...
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Immediate Repeat Prostate Biopsy May Be Unnecessary in Most ASAP Cases - Renal and Urology News
Posted: November 19th, 2015, 6:00am GMT
Immediate Repeat Prostate Biopsy May Be Unnecessary in Most ASAP Cases Renal and Urology NewsRelatively few men with atypical small acinar proliferation are found to have high-grade prostate cancer on repeat biopsy.
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Immediate Repeat Prostate Biopsy May Be Unnecessary in Most ASAP Cases - Renal and Urology News
Posted: November 19th, 2015, 6:00am GMT
Immediate Repeat Prostate Biopsy May Be Unnecessary in Most ASAP Cases Renal and Urology NewsRelatively few men with atypical small acinar proliferation are found to have high-grade prostate cancer on repeat biopsy.
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Aggressive Lung Adenocarcinoma Subtype May Require New Treatment Strategy - Memorial Sloan Kettering Cancer Center
Posted: September 17th, 2015, 5:00am GMT
Aggressive Lung Adenocarcinoma Subtype May Require New Treatment Strategy Memorial Sloan Kettering Cancer CenterDoctors are now able to identify whether patients with early-stage lung adenocarcinoma have an aggressive form called solid predominant subtype. Following ...
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Histologic Classification Could Aid Prognosis in Lung Adenocarcinoma - Cancer Network
Posted: August 11th, 2015, 5:00am GMT
Histologic Classification Could Aid Prognosis in Lung Adenocarcinoma Cancer NetworkNew classification guidelines for histologic subtypes of stage I lung adenocarcinoma offer prognostic value, according to a recent study.
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Histologic Classification Could Aid Prognosis in Lung Adenocarcinoma - Cancer Network
Posted: August 11th, 2015, 5:00am GMT
Histologic Classification Could Aid Prognosis in Lung Adenocarcinoma Cancer NetworkNew classification guidelines for histologic subtypes of stage I lung adenocarcinoma offer prognostic value, according to a recent study.
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Heat-shock factor 2 is a suppressor of prostate cancer invasion - Nature.com
Posted: June 29th, 2015, 5:00am GMT
Heat-shock factor 2 is a suppressor of prostate cancer invasion Nature.comHeat-shock factors (HSFs) are key transcriptional regulators in cell survival. Although HSF1 has been identified as a driver of carcinogenesis, HSF2 has not ...
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Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers - Nature.com
Posted: June 15th, 2015, 5:00am GMT
Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers Nature.comDifferentiated epithelial structure communicates with individual constituent epithelial cells to suppress their proliferation activity. However, the pathways linking ...
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Role of α1 and α2 chains of type IV collagen in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts - Nature.com
Posted: May 25th, 2015, 5:00am GMT
Role of α1 and α2 chains of type IV collagen in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts Nature.comEarly fibrotic lesions are thought to be the initial findings of fibrogenesis in idiopathic interstitial pneumonias, but little is known about their properties. Type IV ...
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Chad Scott Strawn - Coos Bay World
Posted: April 25th, 2015, 5:00am GMT
Chad Scott Strawn Coos Bay WorldChad was born on Dec. 13, 1966, to Darrell and Joyce Strawn in Coos Bay, Ore. He spent his childhood in North Bend, Ore., with family and Grandparents, ...
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Low Testosterone May Indicate Prostate Cancer Progression - Cancer Network
Posted: May 8th, 2014, 5:00am GMT
Low Testosterone May Indicate Prostate Cancer Progression Cancer NetworkLow testosterone levels may indicate disease worsening in men diagnosed with low-risk prostate cancer who are being evaluated by active surveillance, ...
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Newport's Andrew Rodman -- surfer, poet and editor -- reaches into his beliefs to beat back cancer on his own terms - OregonLive.com
Posted: November 29th, 2011, 6:00am GMT
Newport's Andrew Rodman -- surfer, poet and editor -- reaches into his beliefs to beat back cancer on his own terms OregonLive.comRodman, well known on Oregon's central coast as a poet, artist, surfer and editor of the magazine "In Good Tilth," drew on his knowledge of the organic world to ...
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Newport's Andrew Rodman -- surfer, poet and editor -- reaches into his beliefs to beat back cancer on his own terms - OregonLive.com
Posted: November 29th, 2011, 6:00am GMT
Newport's Andrew Rodman -- surfer, poet and editor -- reaches into his beliefs to beat back cancer on his own terms OregonLive.comRodman, well known on Oregon's central coast as a poet, artist, surfer and editor of the magazine "In Good Tilth," drew on his knowledge of the organic world to ...
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Monitoring of Gustatory Stimulation of Salivary Glands by Diffusion-Weighted MR Imaging: Comparison of 1.5T and 3T - AJNR (subscription)
Posted: September 30th, 2011, 9:57am GMT
Monitoring of Gustatory Stimulation of Salivary Glands by Diffusion-Weighted MR Imaging: Comparison of 1.5T and 3T AJNR (subscription)C.R. Habermann, P. Gossrau, H. Kooijman, J. Graessner, M.C. Cramer, M.G. Kaul, F. Reitmeier, M. Jaehne and G. Adam. American Journal of Neuroradiology ...
PubMed - Acinar Cell Carcinoma
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Mixed Malignant Pancreatic Tumour in a Rhesus Macaque (Macaca mullata).
Fetched: March 24th, 2019, 5:00am GMT
Related Articles Mixed Malignant Pancreatic Tumour in a Rhesus Macaque (Macaca mullata).
J Comp Pathol. 2019 Feb;167:46-49
Authors: Olstad KJ, Kasantikul T, Kiupel M, Reader JR
Abstract
Pancreatic islet cell tumours are rare in non-human primates. The majority of reported cases are benign islet cell adenomas in rhesus macaques (Macaca mullata). Here we describe a pancreatic tumour composed of both exocrine and endocrine cells known as a mixed acinar-neuroendocrine carcinoma in a captive rhesus macaque. A diagnosis of a mixed tumour requires intermingling of neoplastic exocrine and neuroendocrine cells and must be differentiated from ductal adenocarcinomas in which only the ductal component is neoplastic with interspersed normal neuroendocrine cells. Immunohistochemistry, including antibodies against cytokeratin 7 and chromogranin A, was used to demonstrate that both exocrine and endocrine neoplastic cells exhibited cellular atypia, invasion into the adjacent parenchyma and intraparenchymal metastasis consistent with a mixed malignant tumour. Expression of multiple hormones such as gastrin, insulin, pancreatic polypeptide and somatostatin was also observed throughout the neoplastic cell population, while the endocrine component of the neoplasm was predominantly positive for glucagon.
PMID: 30898297 [PubMed - in process]
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Acinic Cell Carcinoma of the Parotid Gland in Children and Adolescents.
Fetched: March 23rd, 2019, 5:00am GMT
Related Articles Acinic Cell Carcinoma of the Parotid Gland in Children and Adolescents.
J Pediatr Hematol Oncol. 2018 03;40(2):99-103
Authors: Ash S, Yaniv I, Feinmesser R, Konen O, Feinmesser M
Abstract
Acinic cell carcinoma of the parotid gland is a rare low-grade malignant neoplasm. Data on children are sparse. For the present study, the database of a tertiary pediatric medical center was reviewed for all patients with parotid gland acinic cell carcinoma diagnosed and treated between 2004 and 2013. Clinical, histologic, treatment, and outcome parameters were collected from the medical files. Four patients were identified, 3 female and 1 male, aged 13.5 to 18 years (median 15.7) at diagnosis. One patient had a family history of parotid tumor and 1 of hypothyroidism/hyperthyroidism. Two patients had L-thyroxin-treated Hashimoto thyroiditis, and 1 had a thyroid nodule. All presented with a localized parotid mass and negative lymph nodes. Treatment consisted of partial parotidectomy, with no damage to the facial nerve. Histology confirmed the diagnosis of acinic cell carcinoma with low proliferation rate (Ki67 immunostaining 1% to 8%). No evidence of disease was found on any patient with a median follow-up at 83 months (range, 32 to 93 mo) from presentation. In our experience, the prognosis of pediatric parotid gland acinic cell carcinoma is good, and surgery alone is sufficient for treatment of early stage tumors. This is the first report of findings of a family history of thyroid disease and/or thyroid abnormalities in patients with parotid gland acinic cell carcinoma.
PMID: 29240035 [PubMed - indexed for MEDLINE]
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MR imaging features of pancreatic acinar cell carcinoma.
Fetched: March 10th, 2019, 5:00am GMT
Related Articles MR imaging features of pancreatic acinar cell carcinoma.
Diagn Interv Imaging. 2019 Mar 04;:
Authors: Jornet D, Soyer P, Terris B, Hoeffel C, Oudjit A, Legmann P, Gaujoux S, Barret M, Dohan A
Abstract
PURPOSE: This study aimed to report the magnetic resonance imaging (MRI) features of acinar cell carcinoma (ACC) of the pancreas including diffusion-weighted MRI findings.
MATERIALS AND METHODS: The MRI examinations of five patients (3 men, 2 women; median age, 61years) with histopathologically proven ACC of the pancreas were retrospectively reviewed. MR images were analyzed qualitatively (location, shape, homogeneity, signal intensity, vascular involvement and extrapancreatic extent of ACC) and quantitatively (tumor size, apparent diffusion coefficient [ADC] and normalized ADC of ACC).
RESULTS: All ACC were visible on MRI, presenting as an oval pancreatic mass (5/5; 100%), with moderate and heterogeneous enhancement (5/5; 100%), with a median transverse diameter of 43mm (Q1, 35; Q3, 82mm; range: 30-91mm). Tumor capsule was visible in 4/5 ACC (80%) and Wirsung duct enlargement in 2/5 ACC (40%). On diffusion-weighted MRI, all ACC (5/5; 100%) were hyperintense on the 3 b value images. Median ADC value of ACC was 1.061×10-3mm2/s (Q1, 0.870×10-3mm2/s; Q3, 1.138×10-3mm2/s; range: 0.834-1.195×10-3mm2/s). Median normalized ADC ratio of ACC was 1.127 (Q1, 1.071; Q3, 1.237; range: 1.054-1.244).
CONCLUSIONS: On MRI, ACC of the pancreas presents as a large, oval pancreatic mass with moderate and heterogeneous enhancement after intravenous administration of a gadolinium chelate, with restricted diffusion and a median ADC value of 1.061×10-3mm2/s on diffusion-weighted MRI. Further studies however are needed to confirm our findings obtained in a limited number of patients.
PMID: 30846400 [PubMed - as supplied by publisher]
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Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury.
Fetched: March 9th, 2019, 5:00am GMT
Related Articles Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury.
Oncogene. 2018 04;37(14):1845-1856
Authors: Fendrich V, Jendryschek F, Beeck S, Albers M, Lauth M, Esni F, Heeger K, Dengler J, Slater EP, Holler JPN, Baier A, Bartsch DK, Waldmann J
Abstract
Pancreatic cancer (PDAC) is one of the most dismal of human malignancies. Inhibiting or delaying the progression of precursor lesions of PDAC, pancreatic intraepthial neoplasia (PanINs), to invasive cancer, would be a major step. In the present study, we used a transgenic murine model of pancreatic cancer to evaluate the impact of a conditional knockout of the transcription factor Snail1, a major factor in epithelial-to-mesenchymal transition, on acinar-to-ductal formation and on PanIN progression. By interbreeding conditional LsL-Snail floxf/wt ; LsL-Kras G12D and Pdx1-Cre strains, we obtained LsL-Kras G12D ;Pdx1-Cre(KP) mice, Snail1 heterozygous knockout LsL-Kras G12D ; LsL-Snail flox/- ;Pdx1-Cre(KPShet) mice or Snail1 homozygous knockout LsL-Kras G12D ;LsL-Snail flox/flox ;Pdx1-Cre(KPS) mice. Mice were then followed in a longitudinal study for 2, 4, 6, 8, 10, and 12 months. Furthermore, in mice with a genetic or pharmacological inhibition of Snail1, using the Snail1 inhibitor GN25, a model of pancreatic injury by administration of cerulein was introduced to evaluate ADM formation in this setting. A translational approach with a tissue microarray (TMA) of human PanINs and an in vivo nude mouse platform to test GN25 in human pancreatic adenocarcinoma was then adopted. Quantification of PanINs showed delayed initiation and progression of PanIN lesions at all ages in both homozygous and heterozygous Snaildel1;Pdx-1-Cre;LSL-KrasG12D/+-Mice. PanINs at TMA revealed snail expression in the majority of cases. GN25 showed growth inhibition in 2/2 human pancreatic adenocarcinomas using a nude mice in vivo platform. Genetic and pharmacologic abrogation of Snail1 signaling in exocrine pancreas impairs development of acinar-to-ductal metaplasia following cerulein-mediated pancreatic injury. The present study suggests a fundamental new approach to delay the progression of PDAC.
PMID: 29367759 [PubMed - indexed for MEDLINE]
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SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer.
Fetched: March 8th, 2019, 5:00am GMT
Related Articles SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer.
Oncogene. 2018 02 15;37(7):912-923
Authors: Zhou H, Qin Y, Ji S, Ling J, Fu J, Zhuang Z, Fan X, Song L, Yu X, Chiao PJ
Abstract
SRY (sex determining region Y)-box 9 (SOX9) is required for oncogenic Kras-mediated acinar-to-ductal metaplasia (ADM), pancreatic intraepithelial neoplasias (PanINs) and ultimately pancreatic ductal adenocarcinoma (PDAC). However, how oncogenic Kras affects SOX9 activity is not yet understood, and SOX9-associated genes in PDAC are also unknown at all. Here, we investigated the mechanistic link between SOX9 and oncogenic Kras, studied biological function of SOX9, and identified SOX9-related genes and their clinical significance in patients with PDAC. Our studies reveal that oncogenic Kras induces SOX9 mRNA and protein expression as well as phosphorylated SOX9 expression in human pancreatic ductal progenitor cells (HPNE) and pancreatic ductal cells (HPDE). Moreover, oncogenic Kras promoted nuclear translocation and transcriptional activity of SOX9 in these cells. TAK1/IκBα/NF-κB pathway contributed to induction of SOX9 by oncogenic Kras, and SOX9 in turn enhanced NF-κB activation. SOX9 promoted the proliferation of HPNE and PDAC cells, and correlated with minichromosome maintenance complex components (MCMs) and mediator of DNA damage checkpoint 1 (MDC1) expression. The overexpressive MDC1 was associated with less perineural and lymph node invasion of tumors and early TNM-stage of patients. Our results indicate that oncogenic Kras induces constitutive activation of SOX9 in HPNE and HPDE cells, and Kras/TAK1/IκBα/NF-κB pathway and a positive feedback between SOX9 and NF-κB are involved in this inducing process. SOX9 accelerates proliferation of cells and affects MCMs and MDC1 expression. MDC1 is associated negatively with invasion and metastasis of PDAC.
PMID: 29059173 [PubMed - indexed for MEDLINE]
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Monoclonal Antibody Production Against Vimentin by Whole Cell Immunization in a Mouse Model.
Fetched: February 27th, 2019, 5:00am GMT
Related Articles Monoclonal Antibody Production Against Vimentin by Whole Cell Immunization in a Mouse Model.
Iran J Biotechnol. 2018 May;16(2):e1802
Authors: Rezaei M, Ghaderi A
Abstract
Background: Pancreatic carcinoma is the fourth-leading cause of cancer death in the United States and due to its late presentation, only few patients would be candidates for the curative treatment of pancreactomy. Monoclonal antibodies have brought hope to targeted therapy.
Objectives: To identify new biomarkers, a panel of monoclonal antibodies was generated against newly established cell line, Faraz-ICR from a patient with pancreatic acinar cell carcinoma.
Material and Methods: Balb/c female mice were immunized with Faraz-ICR cell line and their spleenocytes fused with SP2/0 myeloma cell line. Highly reactive hybridoma producing antibodies against Faraz-ICR was detected using ELISA, immunofluorescence staining and flow cytometry. Western blot and 2D immunoblot were utilized for further characterization of the target antibodies.
Results: Among highly reactive clones, the reactivity of 7C11 clone was assessed in comparison to other epithelial tumors. The antibody isotype was IgM that reacted with a 55 kDa protein in western blot analysis. To further characterize the target antigen, immunoproteome of the Faraz-ICR cell line was performed. By LC-MS analysis, the target of 7C11 clone was identified to be vimentin.
Conclusions: Pancreatic cancer is a highly lethal malignancy with no reliable biomarker for early detection and diagnosis. In this study, by establishing a pancreatic acinar carcinoma cell line, a panel of monoclonal antibodies was generated to identify specific or associated cancer targets. Furthermore, 7C11 mAb was introduced that can specifically recognizes vimentin as a tumor marker. This antibody may serve as a new tool for prognostic and therapeutic strategies.
PMID: 30805388 [PubMed]
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Alpha-L-fucosidase-1 is a diagnostic marker that distinguishes mucoepidermoid carcinoma from squamous cell carcinoma.
Fetched: February 9th, 2019, 5:00am GMT
Related Articles Alpha-L-fucosidase-1 is a diagnostic marker that distinguishes mucoepidermoid carcinoma from squamous cell carcinoma.
Pathol Int. 2019 Feb 06;:
Authors: Ishida S, Kayamori K, Sakamoto K, Yukimori A, Kugimoto T, Harada H, Ikeda T
Abstract
Alpha-L-fucose is a component of glycans on the cell surface. Alpha-L-fucose is correlated with tumorigenesis and malignancy, and alpha-L-fucosidase-1 (FUCA1), the enzyme that removes terminal α-L-fucose residues from glycoproteins, is downregulated in some high malignancy cancers. The expression profile of FUCA1 in head and neck tumors remains unknown, and we analyzed the expression profiles of FUCA1 and an upstream molecule p53 in mucoepidermoid carcinoma (MEC) and oral squamous cell carcinoma (OSCC). FUCA1 was expressed in most MECs irrespective of histopathological grading, whereas expression in OSCCs was low. High immunohistochemical intensity of p53 was detected in OSCCs at high frequency, but rarely detected in MECs. Genetic mutation analysis using next-generation sequencing revealed no significant mutation of TP53 in MECs. We further analyzed the expression profiles of FUCA1 in normal major and minor salivary glands and found strong expression in the intercalated duct, moderate expression in mucous acinar cells and no expression in serous acinar cells. These contrasting immunohistochemical profiles and anatomical distribution in normal salivary glands suggest that FUCA1 is a useful marker to distinguish MEC from OSCC, and many MECs have similar immunohistochemical phenotypes to intercalated duct and mucous acinar cells.
PMID: 30729618 [PubMed - as supplied by publisher]
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Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands.
Fetched: February 7th, 2019, 5:00am GMT
Related Articles Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands.
Nat Commun. 2019 01 21;10(1):368
Authors: Haller F, Bieg M, Will R, Körner C, Weichenhan D, Bott A, Ishaque N, Lutsik P, Moskalev EA, Mueller SK, Bähr M, Woerner A, Kaiser B, Scherl C, Haderlein M, Kleinheinz K, Fietkau R, Iro H, Eils R, Hartmann A, Plass C, Wiemann S, Agaimy A
Abstract
The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. The secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosphoproteins of which some are specifically expressed at high levels in the salivary glands and constitute major components of saliva. Here we report on recurrent rearrangements [t(4;9)(q13;q31)] in AciCC that translocate active enhancer regions from the SCPP gene cluster to the region upstream of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) at 9q31. We show that NR4A3 is specifically upregulated in AciCCs, and that active chromatin regions and gene expression signatures in AciCCs are highly correlated with the NR4A3 transcription factor binding motif. Overexpression of NR4A3 in mouse salivary gland cells increases expression of known NR4A3 target genes and has a stimulatory functional effect on cell proliferation. We conclude that NR4A3 is upregulated through enhancer hijacking and has important oncogenic functions in AciCC.
PMID: 30664630 [PubMed - indexed for MEDLINE]
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[Multiple lung carcinoma: Primary or intrapulmonary metastasis?]
Fetched: February 6th, 2019, 5:00am GMT
Related Articles [Multiple lung carcinoma: Primary or intrapulmonary metastasis?]
Ann Pathol. 2018 Jun;38(3):202-205
Authors: Ravella L, Barritault M, Bringuier PP, Chalabreysse L, Thivolet-Bejui F, Maury JM, Duruisseaux M, Brevet M
Abstract
Multiple lung carcinomas are 5 to 11,5% of lung carcinomas. The distinction between primary lung carcinomas from carcinomas with intrapulmonary metastasis is essential for optimal patient management. The histopathological analysis is very useful but it has to be completed by genotypic assessment using molecular biology (NGS). Molecular biology can also identify genetic alterations with therapeutic implications. We present the case of a patient with a history of surgery for multiple lung carcinomas diagnosed from 2013 to 2017.
PMID: 29555057 [PubMed - indexed for MEDLINE]
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Slowly Enlarging Neck Mass.
Fetched: February 6th, 2019, 5:00am GMT
Related Articles Slowly Enlarging Neck Mass.
JAMA Otolaryngol Head Neck Surg. 2017 06 01;143(6):629-630
Authors: Chase T, Dingle I, Ridley MB
PMID: 28358940 [PubMed - indexed for MEDLINE]
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Acinic cell carcinoma of parotid gland with cavernous sinus metastasis: A case report.
Fetched: February 3rd, 2019, 5:00am GMT
Related Articles Acinic cell carcinoma of parotid gland with cavernous sinus metastasis: A case report.
J Cancer Res Ther. 2018 Oct-Dec;14(6):1428-1430
Authors: Francis Thottian AG, Gandhi AK, Ramateke PP, Gogia A
Abstract
Acinic cell carcinoma (AciCC) is a low-grade malignancy which rarely metastasizes to bone or cavernous sinuses. A 62-year-old male patient, previously treated for AciCC of right parotid with surgery and local radiotherapy, presented 10 years later with progressive visual impairment and restriction of ocular movements. Magnetic resonance imaging of the head and orbit showed an expansile lobulated mass with heterogeneous signal intensity in bilateral cavernous sinus with encasement of the internal carotid artery on both sides. Fluorodeoxyglucose positron emission tomography/computed tomography showed multiple lytic lesions with increased uptake in the left clavicle (with soft tissue component), sternum, multiple cervico-dorso-lumbar vertebrae, and ribs. Biopsy from the clavicular lesion showed AciCC. He was treated with palliative radiotherapy to cavernous sinuses and other metastatic site followed by palliative chemotherapy with six cycles of paclitaxel and carboplatin. He had a partial response to palliative treatment and had good symptomatic relief at 12 months of follow-up.
PMID: 30488869 [PubMed - indexed for MEDLINE]
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Natural History and Treatment Trends in Pancreatic Cancer Subtypes.
Fetched: February 3rd, 2019, 5:00am GMT
Related Articles Natural History and Treatment Trends in Pancreatic Cancer Subtypes.
J Gastrointest Surg. 2019 Jan 31;:
Authors: Pokrzywa CJ, Abbott DE, Matkowskyj KA, Ronnekleiv-Kelly SM, Winslow ER, Weber SM, Fisher AV
Abstract
BACKGROUND: While pancreatic ductal adenocarcinoma is the most common form of pancreatic cancer, many other histologic forms of pancreatic cancer are also recognized. These histologic variants portray unique characteristics in terms of patient demographics, tumor behavior, survival, and responsiveness to treatments.
MATERIALS AND METHODS: Patients who underwent surgical resection of the pancreas for non-metastatic, invasive pancreatic cancer between 2004 and 2014 were selected from the National Cancer Data Base and categorized by histologic variant according to WHO classification guidelines. Patient demographics, tumor variables, treatment characteristics, and survival were compared between histologic groups and subgroups.
RESULTS: A total of 57,804 patients met inclusion and exclusion criteria and were grouped into eight major histologic categories. Survival analysis by the histologic group showed median overall survival of 20.2 months for ductal adenocarcinoma, 20.5 months for squamous cell carcinoma, 26.8 months for mixed acinar-neuroendocrine carcinomas, 52.6 months for cystic mucinous neoplasms with an associated invasive carcinoma, 67.5 months for acinar cell carcinoma, and 69.3 months for mesenchymal tumors. Median survival was not reached for neuroendocrine tumors and solid-pseudopapillary neoplasms, with 5-year overall survival rates of 84% and 97% respectively.
CONCLUSIONS: Rare subtypes of pancreatic cancer present unique clinicopathologic characteristics and display distinct tumor biologies. This study presents data on demographic, prognostic, treatment, and survival outcomes between rare forms of pancreatic neoplasms in order to aid understanding of the natural history and behavior of these neoplasms, with the hope of serving as a reference in clinical decision-making and ability to provide accurate prognostic information to patients.
PMID: 30706376 [PubMed - as supplied by publisher]
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CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas.
Fetched: January 31st, 2019, 5:00am GMT
Related Articles CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas.
Virchows Arch. 2019 Jan;474(1):105-109
Authors: Lawlor RT, Daprà V, Girolami I, Pea A, Pilati C, Nottegar A, Piccoli P, Parolini C, Sperandio N, Capelli P, Scarpa A, Luchini C
Abstract
CD200 has been recently indicated as a robust marker of well-differentiated neuroendocrine neoplasms. Here, we evaluate its role in differential diagnosis of solid pancreatic neoplasms. We immunostained for CD200 22 solid pseudopapillary neoplasms (SPNs), 8 acinar carcinomas (ACs), 2 pancreatoblastomas (PBs), 138 neuroendocrine tumors (PanNETs), and 48 ductal adenocarcinomas. All SPNs showed strong cytoplasmic and membranous staining for CD200, while only one case of AC had focal positivity. The two PBs showed focal CD200 positivity, mainly located in squamoid nests. The vast majority of PanNETs (96%) showed strong cytoplasmic and membranous staining for CD200, whereas all PDACs were negative. As both PanNETs and SPNs express CD200, it has no role in the differential diagnosis between these two entities.
PMID: 30132130 [PubMed - indexed for MEDLINE]
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[A Case of Pancreatic Acinar Cell Carcinoma in a Young Woman without Recurrence after Systemic Chemotherapy Using S-1].
Fetched: January 31st, 2019, 5:00am GMT
Related Articles [A Case of Pancreatic Acinar Cell Carcinoma in a Young Woman without Recurrence after Systemic Chemotherapy Using S-1].
Gan To Kagaku Ryoho. 2018 Dec;45(13):2315-2317
Authors: Tsuruta S, Kimura N, Ishido K, Kudo D, Sakuraba S, Sawano T, Suto A, Wakasa Y, Hakamada K
Abstract
A 26-year-old woman underwent laparoscopic-assisted distal pancreatectomy and splenectomy for a tumor in the tail of the pancreas. Although the preoperative diagnosis was a solid pseudopapillary tumor, pathological tissue examination revealed that the tumor was a pancreatic acinar cell carcinoma. She was treated with S-1 chemotherapy for 6 months without severe side effects, and no recurrence was detected on several imaging inspections. Acinar cell carcinoma of the pancreas is a rare tumor in young patients, and there are few reports of treatment with postoperative chemotherapy.
PMID: 30692449 [PubMed - in process]
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KRAS mutation and epithelial-macrophage interplay in pancreatic neoplastic transformation.
Fetched: January 28th, 2019, 5:00am GMT
Related Articles KRAS mutation and epithelial-macrophage interplay in pancreatic neoplastic transformation.
Int J Cancer. 2018 10 15;143(8):1994-2007
Authors: Bishehsari F, Zhang L, Barlass U, Preite NZ, Turturro S, Najor MS, Shetuni BB, Zayas JP, Mahdavinia M, Abukhdeir AM, Keshavarzian A
Abstract
Pancreatic ductal adenocarcinoma (PDA) is characterized by epithelial mutations in KRAS and prominent tumor-associated inflammation, including macrophage infiltration. But knowledge of early interactions between neoplastic epithelium and macrophages in PDA carcinogenesis is limited. Using a pancreatic organoid model, we found that the expression of mutant KRAS in organoids increased (i) ductal to acinar gene expression ratios, (ii) epithelial cells proliferation and (iii) colony formation capacity in vitro, and endowed pancreatic cells with the ability to generate neoplastic tumors in vivo. KRAS mutations induced a protumorigenic phenotype in macrophages. Altered macrophages decreased epithelial pigment epithelial derived factor (PEDF) expression and induced a cancerous phenotype. We validated our findings using annotated patient samples from The Cancer Genome Atlas (TCGA) and in our human PDA specimens. Epithelium-macrophage cross-talk occurs early in pancreatic carcinogenesis where KRAS directly induces cancer-related phenotypes in epithelium, and also promotes a protumorigenic phenotype in macrophages, in turn augmenting neoplastic growth.
PMID: 29756386 [PubMed - indexed for MEDLINE]
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Novel interleukin-33 and its soluble ST2 receptor as potential serum biomarkers in parotid gland tumors.
Fetched: January 25th, 2019, 5:00am GMT
Related Articles Novel interleukin-33 and its soluble ST2 receptor as potential serum biomarkers in parotid gland tumors.
Exp Biol Med (Maywood). 2018 05;243(9):762-769
Authors: Sowa P, Misiolek M, Zielinski M, Mazur B, Adamczyk-Sowa M
Abstract
An increasing number of patients with parotid gland tumors have been observed in recent years. The relationship between the immune system and tumor formation is thoroughly investigated. However, newly discovered molecules offer a new insight into the pathophysiology of malignancies. It would be ideal to find an easily determinable biomarker of tumor existence, its malignant potential or a biomarker suggesting the probability of disease recurrence. Our study is the first to examine serum concentrations of IL-33 and its sST2 receptor in patients with various types of parotid gland tumors. Serum IL33, sST2, IL-4 and IL-10 concentrations were determined in patients with benign and malignant parotid gland tumors (pleomorphic adenoma, Warthin's tumor, myoepithelioma and acinic cell carcinoma). We observed for the first time that serum IL-33 level was significantly elevated in patients with various types of parotid gland tumors and sST2 levels were significantly higher in pleomorphic adenoma and acinic cell carcinoma patients compared to the controls. Our results demonstrate for the first time that serum IL-33 and its sST2 receptor may be important factors in the pathology of parotid gland tumors. Although our results are promising, further investigations are required to detect if serum concentrations of those molecules may be a biomarker in parotid gland tumors. Impact statement Parotid gland tumors seem to be an increasingly important medical challenge, mostly due to a noticeable increase in the incidence. It would be crucial to find an easily determinable biomarker of tumor existence, its recurrence or malignant potential. We observed for the first time that serum IL-33 level was significantly elevated in patients with various types of parotid gland tumors and its sST2 receptor levels were significantly higher in pleomorphic adenoma and acinic cell carcinoma patients compared to the controls. We believe that our study helps to understand the biology of the tumors and a potential role of a relatively newly identified cytokine IL-33 in the pathophysiology of the parotid gland tumors.
PMID: 29763370 [PubMed - indexed for MEDLINE]
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Undiagnosed paraganglioma; A challenge during laparoscopic retroperitoneal resection.
Fetched: January 20th, 2019, 5:00am GMT
Related Articles Undiagnosed paraganglioma; A challenge during laparoscopic retroperitoneal resection.
Arch Ital Urol Androl. 2019 Jan 17;90(4):297-298
Authors: Heinze A, Nikomanis P, Petzold F, Rassweiler JJ, Goezen AS
Abstract
OBJECTIVE: Report our experience of the management of a patient with undiagnosed retroperitoneal paraganglioma and the intraoperative complications that the theatre team faced.
CASE REPORT: We present a case of a 36-year-old patient who during oncological follow-up for a previous diagnosis of parotid acinar cell carcinoma was incidentally identified as having an interaortocaval tumour. Following routine preoperative assessment the patient was arranged to undergo a laparoscopic retroperitoneal tumour resection. After minimal tumour manipulation the patient developed cardiac rhythm abnormalities and became hypertensive. The tumour was successfully removed laparoscopically after a cautious inter- aortocaval dissection. Abruptly, prior to extraction of the tumour containing endobag, the patient developed cardiac arrest. Following 35 minutes of life support measures there was a return of spontaneous circulation. The endobag was laparoscopically removed from the abdominal cavity 24 hours later using the initial operative port sites. The patient´s progression was satisfactory and he could be discharged six days postoperatively.
CONCLUSIONS: Asymptomatic undiagnosed paragangliomas represent a real challenge during laparoscopic operations. Haemodynamic changes and life-threatening events can arise acutely intraoperatively, where an immediate and coordinated response of the whole theatre team may be required to avoid fatal outcome.
PMID: 30655644 [PubMed - in process]
Google - Acinic Cell Carcinoma
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Community raises 20,000 for Hingham teacher with cancer - Wicked Local
Posted: March 5th, 2019, 9:30pm GMT
Community raises 20,000 for Hingham teacher with cancer Wicked LocalA GoFundMe page raised $20000 in eight days for Hingham Middle School teacher Allison Clarke, who has a rare and incurable head and neck cancer.
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Community raises 20,000 for Hingham teacher with cancer - Wicked Local
Posted: March 5th, 2019, 9:30pm GMT
Community raises 20,000 for Hingham teacher with cancer Wicked LocalA GoFundMe page raised $20000 in eight days for Hingham Middle School teacher Allison Clarke, who has a rare and incurable head and neck cancer.
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Dunstable author hopes Sunny Days will inspire others - Dunstable Today
Posted: February 26th, 2019, 8:13am GMT
Dunstable author hopes Sunny Days will inspire others Dunstable TodayAn author from Dunstable is hoping her first book will inspire others to overcome any challenges they face in their life.
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Commissioner Julie Carson Diagnosed With Rare Form of Cancer - SouthFloridaGayNews.com
Posted: February 21st, 2019, 4:44pm GMT
Commissioner Julie Carson Diagnosed With Rare Form of Cancer SouthFloridaGayNews.comCity Commissioner Julie Carson has been diagnosed with a rare form of salivary gland cancer and will undergo surgery to treat the condition in mid-March.
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Commissioner Julie Carson Diagnosed With Rare Form of Cancer - SouthFloridaGayNews.com
Posted: February 21st, 2019, 6:00am GMT
Commissioner Julie Carson Diagnosed With Rare Form of Cancer SouthFloridaGayNews.comCity Commissioner Julie Carson has been diagnosed with a rare form of salivary gland cancer and will undergo surgery to treat the condition in mid-March.
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Genetic causes of tumors in salivary glands - Medical Xpress
Posted: January 31st, 2019, 6:00am GMT
Genetic causes of tumors in salivary glands Medical XpressAcinic cell carcinoma is the third most common malignant form of salivary gland cancer. These tumours are similar to normal salivary gland tissue and occur ...
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Genetic causes of tumors in salivary glands - Science Daily
Posted: January 31st, 2019, 11:15pm GMT
Genetic causes of tumors in salivary glands Science DailyAcinic cell carcinoma is the third most common malignant form of salivary gland cancer. These tumors are similar to normal salivary gland tissue and occur most ...
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Student fights her way to health, looks to give back by helping others abroad - The Auburn Plainsman
Posted: January 27th, 2019, 9:47pm GMT
Student fights her way to health, looks to give back by helping others abroad The Auburn PlainsmanEverything is meant to be overcome. If you don't fight your battles head-on, you lose a part of who you could be.”
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What are Carcinomas? - News-Medical.net
Posted: December 12th, 2018, 6:00am GMT
What are Carcinomas? News-Medical.netCarcinomas are cancers or malignancies that begin in the epithelial cells. There are several types of carcinomas with different levels of severity.
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Functional salivary gland organoid created - Science Daily
Posted: October 11th, 2018, 5:00am GMT
Functional salivary gland organoid created Science DailyScientists have, for the first time, succeeded in growing three-dimensional salivary gland tissue that, when implanted into mice, produced saliva like normal ...
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Acinic Cell Carcinoma - News-Medical.net
Posted: June 20th, 2018, 11:29pm GMT
Acinic Cell Carcinoma News-Medical.netAs salivary glands are made up of different cells, tumors could start in any one of such. Various salivary gland tumors, which may be benign or malignant, may ...
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Scientists find link between congenital cardiac malformation and adult adrenal cancer: Alteration is in main gene that causes the body to respond to low oxygen - Science Daily
Posted: March 28th, 2018, 5:00am GMT
Scientists find link between congenital cardiac malformation and adult adrenal cancer: Alteration is in main gene that causes the body to respond to low oxygen Science DailyWhy do rare tumors of the adrenal gland sometimes occur in patients who have been born with a severe heart defect that limits their oxygen? Medical ...
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Combination of traditional chemotherapy, new drug kills rare cancer cells in mice - Science Daily
Posted: August 16th, 2017, 5:00am GMT
Combination of traditional chemotherapy, new drug kills rare cancer cells in mice Science DailyAn experimental drug combined with the traditional chemotherapy drug cisplatin, when used in mice, destroyed a rare form of salivary gland tumor and ...
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Immune cells promote or prevent cytomegalovirus activity in mice depending on location: New findings could inform development of treatments that manipulate immune cell activity - Science Daily
Posted: August 10th, 2017, 5:00am GMT
Immune cells promote or prevent cytomegalovirus activity in mice depending on location: New findings could inform development of treatments that manipulate immune cell activity Science DailyImmune system cells called regulatory T cells appear to promote cytomegalovirus (CMV) latency in the spleen of mice, but suppress it in the salivary gland.
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Beauty advisor shares tips with three cancer sufferers on how to stay looking their best - Mirror.co.uk
Posted: May 11th, 2016, 5:00am GMT
Beauty advisor shares tips with three cancer sufferers on how to stay looking their best - Mirror Online Mirror.co.ukA Boots MacMillan beauty advisor has shared her tips on how to look your best with three cancer sufferers.
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Marathon challenge for Peterborough cancer survivor in memory of his dad - Peterborough Telegraph
Posted: March 7th, 2016, 6:00am GMT
Marathon challenge for Peterborough cancer survivor in memory of his dad Peterborough TelegraphA cancer survivor from Peterborough will take on a marathon challenge in memory of his late father - who died after battling cancer himself.
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Turning on the thyroid: Researchers determine mechanism that triggers normal and abnormal hormone production - Science Daily
Posted: January 8th, 2016, 6:00am GMT
Turning on the thyroid: Researchers determine mechanism that triggers normal and abnormal hormone production Science DailyDespite the prevalence of thyroid disease and its sometimes serious effects, researchers have struggled to answer a pretty basic question about the ...
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Punter Adam Podlesh thankful for his family - Rochester Democrat and Chronicle
Posted: November 25th, 2015, 6:00am GMT
Punter Adam Podlesh thankful for his family Rochester Democrat and ChronicleSixteen months since his wife and son nearly died during birth, Pittsford native Adam Podlesh remains thankful. The former NFL punter has a changed ...
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Proton Therapy: A Better Way to Destroy Tumors - Memorial Sloan Kettering Cancer Center
Posted: February 17th, 2015, 6:00am GMT
Proton Therapy: A Better Way to Destroy Tumors Memorial Sloan Kettering Cancer CenterProton therapy uses charged particles to target tumors with precision while reducing the risk of treatment-related side effects.
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Potential link between breast cancer genes, salivary gland cancer - Science Daily
Posted: October 8th, 2014, 5:00am GMT
Potential link between breast cancer genes, salivary gland cancer Science DailyThe risk of developing cancer in a salivary gland might be higher in people with mutations in either of two genes associated with breast and ovarian cancer.
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Jamie Gilmore gets Facebook support after bringing fight against cancer to Texans game - CultureMap Houston
Posted: October 21st, 2012, 5:00am GMT
Jamie Gilmore gets Facebook support after bringing fight against cancer to Texans game CultureMap HoustonWhile the Houston Texans were losing to the Green Bay Packers on the turf last weekend, some fans were experiencing a more personal battle in the stands.
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Enzyme in saliva helps regulate blood glucose - Science Daily
Posted: April 4th, 2012, 5:00am GMT
Enzyme in saliva helps regulate blood glucose Science DailyScientists report that blood glucose levels following starch ingestion are influenced by genetically-determined differences in the oral enzyme salivary amylase.
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Beastie Boy Adam Yauch's Salivary Gland Cancer and Tumor FAQ - WebMD
Posted: July 20th, 2009, 5:00am GMT
Beastie Boy Adam Yauch's Salivary Gland Cancer and Tumor FAQ WebMDJuly 20, 2009 - Beastie Boys member Adam "MCA" Yauch has cancer of the salivary gland with spread to a local lymph node, Yauch says in a video posted ...
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Heavy Cell Phone Use Linked To Cancer, Study Suggests - Science Daily (press release)
Posted: February 15th, 2008, 6:00am GMT
Heavy Cell Phone Use Linked To Cancer, Study Suggests Science Daily (press release)A new study finds an association between heavy cell phone use and tumors of the salivary gland. Those who used a cell phone heavily on the side of the head ...
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Special Scalpel Reduces Blood Loss, Facial Nerve Trauma In Salivary Surgery - Science Daily (press release)
Posted: June 29th, 2005, 5:00am GMT
Special Scalpel Reduces Blood Loss, Facial Nerve Trauma In Salivary Surgery Science Daily (press release)A harmonic scalpel that uses ultrasound to coagulate as it cuts can reduce blood loss and postoperative facial paralysis in patients who need a portion of their ...
PubMed - Acinic Cell Carcinoma
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Mixed Malignant Pancreatic Tumour in a Rhesus Macaque (Macaca mullata).
Fetched: March 24th, 2019, 5:00am GMT
Related Articles Mixed Malignant Pancreatic Tumour in a Rhesus Macaque (Macaca mullata).
J Comp Pathol. 2019 Feb;167:46-49
Authors: Olstad KJ, Kasantikul T, Kiupel M, Reader JR
Abstract
Pancreatic islet cell tumours are rare in non-human primates. The majority of reported cases are benign islet cell adenomas in rhesus macaques (Macaca mullata). Here we describe a pancreatic tumour composed of both exocrine and endocrine cells known as a mixed acinar-neuroendocrine carcinoma in a captive rhesus macaque. A diagnosis of a mixed tumour requires intermingling of neoplastic exocrine and neuroendocrine cells and must be differentiated from ductal adenocarcinomas in which only the ductal component is neoplastic with interspersed normal neuroendocrine cells. Immunohistochemistry, including antibodies against cytokeratin 7 and chromogranin A, was used to demonstrate that both exocrine and endocrine neoplastic cells exhibited cellular atypia, invasion into the adjacent parenchyma and intraparenchymal metastasis consistent with a mixed malignant tumour. Expression of multiple hormones such as gastrin, insulin, pancreatic polypeptide and somatostatin was also observed throughout the neoplastic cell population, while the endocrine component of the neoplasm was predominantly positive for glucagon.
PMID: 30898297 [PubMed - in process]
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Primary Pulmonary Acinic Cell Carcinoma: A Clinicopathological Study of 6 Cases and Literature Review.
Fetched: March 24th, 2019, 5:00am GMT
Related Articles Primary Pulmonary Acinic Cell Carcinoma: A Clinicopathological Study of 6 Cases and Literature Review.
Int J Surg Pathol. 2019 Mar 21;:1066896919836499
Authors: Nie L, Zhou C, Wu H, Zhou Q, Meng F
Abstract
Primary pulmonary acinic cell carcinoma (ACC) is rare. The clinicopathological features are not identical to that of classic ACC that leads to misdiagnosis. In this article, we summarized the clinicopathological features of 25 such cases, including 6 cases in this series and additional 19 cases in the literature. Pulmonary ACCs showed an overwhelming solid growth pattern. The neoplastic cells had eosinophilic granular and clear cytoplasm in most cases and displayed basophilic cytoplasm in only 4 cases. Intratumoral fibrous septa, mitotic figure, necrosis, and psammoma bodies were observed in some cases. Prominent nuclear atypia and perineural invasion might suggest high-grade transformation, metastasis, and recurrence. The tumor cells were strongly positive for CK8/18 and negative for TTF-1, p63, S-100, mammaglobin, MUC5b, MUC5ac, and DOG1. CK7 was exclusively positive for neoplastic cells with ductal differentiation. Of the 25 included cases, 10 cases were initially misdiagnosed. The tumor was prone to involve the right bronchus. The patient outcome was favorable. The accurate diagnosis of primary pulmonary ACC relies on comprehensive evaluation of histological and immunohistochemical features and realization of the difference from classic ACC.
PMID: 30898020 [PubMed - as supplied by publisher]
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MR imaging features of pancreatic acinar cell carcinoma.
Fetched: March 10th, 2019, 5:00am GMT
Related Articles MR imaging features of pancreatic acinar cell carcinoma.
Diagn Interv Imaging. 2019 Mar 04;:
Authors: Jornet D, Soyer P, Terris B, Hoeffel C, Oudjit A, Legmann P, Gaujoux S, Barret M, Dohan A
Abstract
PURPOSE: This study aimed to report the magnetic resonance imaging (MRI) features of acinar cell carcinoma (ACC) of the pancreas including diffusion-weighted MRI findings.
MATERIALS AND METHODS: The MRI examinations of five patients (3 men, 2 women; median age, 61years) with histopathologically proven ACC of the pancreas were retrospectively reviewed. MR images were analyzed qualitatively (location, shape, homogeneity, signal intensity, vascular involvement and extrapancreatic extent of ACC) and quantitatively (tumor size, apparent diffusion coefficient [ADC] and normalized ADC of ACC).
RESULTS: All ACC were visible on MRI, presenting as an oval pancreatic mass (5/5; 100%), with moderate and heterogeneous enhancement (5/5; 100%), with a median transverse diameter of 43mm (Q1, 35; Q3, 82mm; range: 30-91mm). Tumor capsule was visible in 4/5 ACC (80%) and Wirsung duct enlargement in 2/5 ACC (40%). On diffusion-weighted MRI, all ACC (5/5; 100%) were hyperintense on the 3 b value images. Median ADC value of ACC was 1.061×10-3mm2/s (Q1, 0.870×10-3mm2/s; Q3, 1.138×10-3mm2/s; range: 0.834-1.195×10-3mm2/s). Median normalized ADC ratio of ACC was 1.127 (Q1, 1.071; Q3, 1.237; range: 1.054-1.244).
CONCLUSIONS: On MRI, ACC of the pancreas presents as a large, oval pancreatic mass with moderate and heterogeneous enhancement after intravenous administration of a gadolinium chelate, with restricted diffusion and a median ADC value of 1.061×10-3mm2/s on diffusion-weighted MRI. Further studies however are needed to confirm our findings obtained in a limited number of patients.
PMID: 30846400 [PubMed - as supplied by publisher]
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Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury.
Fetched: March 9th, 2019, 5:00am GMT
Related Articles Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury.
Oncogene. 2018 04;37(14):1845-1856
Authors: Fendrich V, Jendryschek F, Beeck S, Albers M, Lauth M, Esni F, Heeger K, Dengler J, Slater EP, Holler JPN, Baier A, Bartsch DK, Waldmann J
Abstract
Pancreatic cancer (PDAC) is one of the most dismal of human malignancies. Inhibiting or delaying the progression of precursor lesions of PDAC, pancreatic intraepthial neoplasia (PanINs), to invasive cancer, would be a major step. In the present study, we used a transgenic murine model of pancreatic cancer to evaluate the impact of a conditional knockout of the transcription factor Snail1, a major factor in epithelial-to-mesenchymal transition, on acinar-to-ductal formation and on PanIN progression. By interbreeding conditional LsL-Snail floxf/wt ; LsL-Kras G12D and Pdx1-Cre strains, we obtained LsL-Kras G12D ;Pdx1-Cre(KP) mice, Snail1 heterozygous knockout LsL-Kras G12D ; LsL-Snail flox/- ;Pdx1-Cre(KPShet) mice or Snail1 homozygous knockout LsL-Kras G12D ;LsL-Snail flox/flox ;Pdx1-Cre(KPS) mice. Mice were then followed in a longitudinal study for 2, 4, 6, 8, 10, and 12 months. Furthermore, in mice with a genetic or pharmacological inhibition of Snail1, using the Snail1 inhibitor GN25, a model of pancreatic injury by administration of cerulein was introduced to evaluate ADM formation in this setting. A translational approach with a tissue microarray (TMA) of human PanINs and an in vivo nude mouse platform to test GN25 in human pancreatic adenocarcinoma was then adopted. Quantification of PanINs showed delayed initiation and progression of PanIN lesions at all ages in both homozygous and heterozygous Snaildel1;Pdx-1-Cre;LSL-KrasG12D/+-Mice. PanINs at TMA revealed snail expression in the majority of cases. GN25 showed growth inhibition in 2/2 human pancreatic adenocarcinomas using a nude mice in vivo platform. Genetic and pharmacologic abrogation of Snail1 signaling in exocrine pancreas impairs development of acinar-to-ductal metaplasia following cerulein-mediated pancreatic injury. The present study suggests a fundamental new approach to delay the progression of PDAC.
PMID: 29367759 [PubMed - indexed for MEDLINE]
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SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer.
Fetched: March 8th, 2019, 5:00am GMT
Related Articles SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer.
Oncogene. 2018 02 15;37(7):912-923
Authors: Zhou H, Qin Y, Ji S, Ling J, Fu J, Zhuang Z, Fan X, Song L, Yu X, Chiao PJ
Abstract
SRY (sex determining region Y)-box 9 (SOX9) is required for oncogenic Kras-mediated acinar-to-ductal metaplasia (ADM), pancreatic intraepithelial neoplasias (PanINs) and ultimately pancreatic ductal adenocarcinoma (PDAC). However, how oncogenic Kras affects SOX9 activity is not yet understood, and SOX9-associated genes in PDAC are also unknown at all. Here, we investigated the mechanistic link between SOX9 and oncogenic Kras, studied biological function of SOX9, and identified SOX9-related genes and their clinical significance in patients with PDAC. Our studies reveal that oncogenic Kras induces SOX9 mRNA and protein expression as well as phosphorylated SOX9 expression in human pancreatic ductal progenitor cells (HPNE) and pancreatic ductal cells (HPDE). Moreover, oncogenic Kras promoted nuclear translocation and transcriptional activity of SOX9 in these cells. TAK1/IκBα/NF-κB pathway contributed to induction of SOX9 by oncogenic Kras, and SOX9 in turn enhanced NF-κB activation. SOX9 promoted the proliferation of HPNE and PDAC cells, and correlated with minichromosome maintenance complex components (MCMs) and mediator of DNA damage checkpoint 1 (MDC1) expression. The overexpressive MDC1 was associated with less perineural and lymph node invasion of tumors and early TNM-stage of patients. Our results indicate that oncogenic Kras induces constitutive activation of SOX9 in HPNE and HPDE cells, and Kras/TAK1/IκBα/NF-κB pathway and a positive feedback between SOX9 and NF-κB are involved in this inducing process. SOX9 accelerates proliferation of cells and affects MCMs and MDC1 expression. MDC1 is associated negatively with invasion and metastasis of PDAC.
PMID: 29059173 [PubMed - indexed for MEDLINE]
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Surgery Alone Is Effective in the Management of Pediatric Salivary Gland Acinic Cell Carcinoma.
Fetched: March 4th, 2019, 5:00am GMT
Related Articles Surgery Alone Is Effective in the Management of Pediatric Salivary Gland Acinic Cell Carcinoma.
J Oral Maxillofac Surg. 2019 Feb 05;:
Authors: Wang C, Mao M, Li B, Kim K, Han Z, Feng Z
Abstract
PURPOSE: The treatment strategy for salivary gland acinic cell carcinoma in pediatric patients remains controversial. This retrospective study was undertaken to analyze the role of surgery in the treatment of acinic cell carcinoma of the major salivary gland in pediatric patients.
PATIENTS AND METHODS: In this retrospective cohort study, we reviewed the medical records of all pediatric patients with acinic cell carcinoma of the major salivary gland who were treated at Beijing Stomatological Hospital of Capital Medical University from 1998 to 2015. The predictor variable was treatment modality. The outcome variables were disease-free survival (DFS), overall survival (OS), local control, and freedom from distant metastasis. Other variables of interest were as follows: age, gender, tumor site, T category, N category, recurrence history, pathologic grade, perineural invasion, extracapsular extension, positive margin, and resection condition. The data analysis methods used were descriptive, bivariate statistics and the Cox proportional hazards regression model.
RESULTS: Of the 19 patients, 7 received surgery alone and 12 received initial surgery combined with postoperative radiotherapy (RT). During the median follow-up period of 86 months, the overall estimates of DFS, OS, local control, and freedom from distant metastasis were 82.6%, 93.3%, 89.5%, and 94.4%, respectively. Good outcomes were achieved in patients who received surgery alone (100% OS and 85.7% DFS). Initial surgery combined with postoperative RT was appropriate for patients with risk factors (91.7% OS and 83.3% DFS).
CONCLUSIONS: Surgery alone is appropriate for salivary gland acinic cell carcinoma in pediatric patients without risk factors, even if extracapsular excision is adopted. Preserving the invaded facial nerve during surgery is a good choice because a curative effect can be obtained when adjuvant RT is administered. Older age, high-grade pathology, incomplete resection, recurrence history, and extracapsular extension were identified as risk factors of poor prognosis.
PMID: 30825434 [PubMed - as supplied by publisher]
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Monoclonal Antibody Production Against Vimentin by Whole Cell Immunization in a Mouse Model.
Fetched: February 27th, 2019, 5:00am GMT
Related Articles Monoclonal Antibody Production Against Vimentin by Whole Cell Immunization in a Mouse Model.
Iran J Biotechnol. 2018 May;16(2):e1802
Authors: Rezaei M, Ghaderi A
Abstract
Background: Pancreatic carcinoma is the fourth-leading cause of cancer death in the United States and due to its late presentation, only few patients would be candidates for the curative treatment of pancreactomy. Monoclonal antibodies have brought hope to targeted therapy.
Objectives: To identify new biomarkers, a panel of monoclonal antibodies was generated against newly established cell line, Faraz-ICR from a patient with pancreatic acinar cell carcinoma.
Material and Methods: Balb/c female mice were immunized with Faraz-ICR cell line and their spleenocytes fused with SP2/0 myeloma cell line. Highly reactive hybridoma producing antibodies against Faraz-ICR was detected using ELISA, immunofluorescence staining and flow cytometry. Western blot and 2D immunoblot were utilized for further characterization of the target antibodies.
Results: Among highly reactive clones, the reactivity of 7C11 clone was assessed in comparison to other epithelial tumors. The antibody isotype was IgM that reacted with a 55 kDa protein in western blot analysis. To further characterize the target antigen, immunoproteome of the Faraz-ICR cell line was performed. By LC-MS analysis, the target of 7C11 clone was identified to be vimentin.
Conclusions: Pancreatic cancer is a highly lethal malignancy with no reliable biomarker for early detection and diagnosis. In this study, by establishing a pancreatic acinar carcinoma cell line, a panel of monoclonal antibodies was generated to identify specific or associated cancer targets. Furthermore, 7C11 mAb was introduced that can specifically recognizes vimentin as a tumor marker. This antibody may serve as a new tool for prognostic and therapeutic strategies.
PMID: 30805388 [PubMed]
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Immunohistochemistry Using a Pan-TRK Antibody Distinguishes Secretory Carcinoma of Salivary Gland from Acinic Cell Carcinoma.
Fetched: February 27th, 2019, 5:00am GMT
Related Articles Immunohistochemistry Using a Pan-TRK Antibody Distinguishes Secretory Carcinoma of Salivary Gland from Acinic Cell Carcinoma.
Histopathology. 2019 Feb 23;:
Authors: Hung YP, Jo VY, Hornick JL
Abstract
AIMS: Secretory carcinoma (previously known as mammary analog secretory carcinoma) is characterized by ETV6 rearrangements, most often ETV6-NTRK3 fusion. Given its histologic overlap with other salivary gland tumors, secretory carcinoma can be difficult to diagnose without genetic confirmation. A recently developed pan-TRK antibody shows promise for identifying tumors with NTRK fusions. This study evaluated the utility of pan-TRK immunohistochemistry in distinguishing secretory carcinoma from mimics.
METHODS AND RESULTS: We examined whole-tissue sections from 86 tumors including 14 secretory carcinomas (12 parotid and 1 buccal primary, 1 metastasis; 5 with ETV6 rearrangement confirmed by fluorescence in situ hybridization, 1 ETV6-NTRK3 and 1 ETV6-RET fusion detected by targeted sequencing), 14 acinic cell carcinomas, 18 polymorphous adenocarcinomas, 20 low-grade mucoepidermoid carcinomas, and 20 pleomorphic adenomas. Immunohistochemistry was performed using a pan-TRK rabbit monoclonal antibody. Pan-TRK staining was detected in 9 (64%) secretory carcinomas, all with nuclear pattern and 4 with diffuse staining (>50% of cells). Of other tumor types, pan-TRK immunoreactivity was observed in all (100%) pleomorphic adenomas (particularly myoepithelial cell-rich, myxoid areas), 15 (83%) polymorphous adenocarcinomas, and 4 (20%) low-grade mucoepidermoid carcinomas, all with predominantly membranous/cytoplasmic immunoreactivity; only 6 cases showed focal (<10%) nuclear staining. All acinic cell carcinomas were entirely negative.
CONCLUSIONS: While pan-TRK expression is not entirely sensitive or specific for secretory carcinoma, nuclear staining distinguishes secretory carcinoma from mimics. Acinic cell carcinomas are negative for pan-TRK, though membranous expression of TRK is common in other salivary gland neoplasms. The lack of pan-TRK immunoreactivity in a subset of secretory carcinomas may suggest non-NTRK fusion partners. This article is protected by copyright. All rights reserved.
PMID: 30801752 [PubMed - as supplied by publisher]
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Alpha-L-fucosidase-1 is a diagnostic marker that distinguishes mucoepidermoid carcinoma from squamous cell carcinoma.
Fetched: February 9th, 2019, 5:00am GMT
Related Articles Alpha-L-fucosidase-1 is a diagnostic marker that distinguishes mucoepidermoid carcinoma from squamous cell carcinoma.
Pathol Int. 2019 Feb 06;:
Authors: Ishida S, Kayamori K, Sakamoto K, Yukimori A, Kugimoto T, Harada H, Ikeda T
Abstract
Alpha-L-fucose is a component of glycans on the cell surface. Alpha-L-fucose is correlated with tumorigenesis and malignancy, and alpha-L-fucosidase-1 (FUCA1), the enzyme that removes terminal α-L-fucose residues from glycoproteins, is downregulated in some high malignancy cancers. The expression profile of FUCA1 in head and neck tumors remains unknown, and we analyzed the expression profiles of FUCA1 and an upstream molecule p53 in mucoepidermoid carcinoma (MEC) and oral squamous cell carcinoma (OSCC). FUCA1 was expressed in most MECs irrespective of histopathological grading, whereas expression in OSCCs was low. High immunohistochemical intensity of p53 was detected in OSCCs at high frequency, but rarely detected in MECs. Genetic mutation analysis using next-generation sequencing revealed no significant mutation of TP53 in MECs. We further analyzed the expression profiles of FUCA1 in normal major and minor salivary glands and found strong expression in the intercalated duct, moderate expression in mucous acinar cells and no expression in serous acinar cells. These contrasting immunohistochemical profiles and anatomical distribution in normal salivary glands suggest that FUCA1 is a useful marker to distinguish MEC from OSCC, and many MECs have similar immunohistochemical phenotypes to intercalated duct and mucous acinar cells.
PMID: 30729618 [PubMed - as supplied by publisher]