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Therapeutic Sialendoscopy for the Management of Radioiodine Sialadenitis - Archives of Otolaryngology

Posted: January 16th, 2012, 12:15pm MST

Therapeutic Sialendoscopy for the Management of Radioiodine Sialadenitis
Archives of Otolaryngology
2 As a result of exposure to this radiation, the parenchymal cells as well as the ductal mucosa experience acute and chronic inflammatory changes. The serous glands and acini are most susceptible; therefore, the parotid glands tend to be more affected ...

Review of small cell carcinomas of the prostate - Abstract - UroToday

Posted: January 8th, 2012, 9:11pm MST

Review of small cell carcinomas of the prostate - Abstract
UroToday
Small cell carcinoma of the prostate is a rare neoplasm, with only a few series hitherto reported. A little less than half of the cases are associated with conventional acinar adenocarcinoma, which are usually high grade. Although consensus has not ...

Newport's Andrew Rodman -- surfer, poet and editor -- reaches into his beliefs ... - OregonLive.com

Posted: November 29th, 2011, 1:42pm MST

OregonLive.com

Newport's Andrew Rodman -- surfer, poet and editor -- reaches into his beliefs ...
OregonLive.com
Only a little more than a month had passed since the November 2010 diagnosis, but in Texas he learned the two tumors had already grown by two centimeters and that he had not one type of cancer, but two: acinar cell carcinoma and neuroendocrine cancer. ...

Cancer diagnosis changes outlook for Podlesh - Rochester Democrat and Chronicle

Posted: November 13th, 2011, 1:34am MST

Cancer diagnosis changes outlook for Podlesh
Rochester Democrat and Chronicle
"He went into the specifics about the cancer, and I immediately started looking up as much information as I could about it." Turns out he had acinic cell carcinoma, a tumor in the parotid gland, the largest of the salivary glands. ...

and more »

Brush with cancer gives Bears punter Podlesh whole new perspective - Winnipeg Free Press

Posted: November 12th, 2011, 3:03am MST

Brush with cancer gives Bears punter Podlesh whole new perspective
Winnipeg Free Press
"He went into the specifics about the cancer, and I immediately started looking up as much information as I could about it." Turns out he had acinic cell carcinoma, a tumour in the parotid gland, the largest of the salivary glands. ...

and more »

Cancer scare gives Podlesh whole new outlook - Washington Examiner

Posted: November 11th, 2011, 8:02pm MST

Washington Examiner

Cancer scare gives Podlesh whole new outlook
Washington Examiner
"He went into the specifics about the cancer, and I immediately started looking up as much information as I could about it." Turns out he had acinic cell carcinoma, a tumor in the parotid gland, the largest of the salivary glands. ...

and more »

Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity.

Fetched: January 21st, 2012, 10:00pm MST

Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity.

J Pathol. 2012 Jan;226(1):108-19

Authors: Giricz O, Reynolds PA, Ramnauth A, Liu C, Wang T, Stead L, Childs G, Rohan T, Shapiro N, Fineberg S, Kenny PA, Loudig O

Abstract
Invasive lobular carcinoma (ILC) of the breast, characterized by loss of E-cadherin expression, accounts for 5-15% of invasive breast cancers and it is believed to arise via a linear histological progression. Genomic studies have identified a clonal relationship between ILC and concurrent lobular carcinoma in situ (LCIS) lesions, suggesting that LCIS may be a precursor lesion. It has been shown that an LCIS diagnosis confers a 15-20% risk of progression to ILC over a lifetime. Currently no molecular test or markers can identify LCIS lesions likely to progress to ILC. Since microRNA (miRNA) expression changes have been detected in a number of other cancer types, we explored whether their dysregulation might be detected during progression from LCIS to ILC. Using the Illumina miRNA profiling platform, designed for simultaneous analysis of 470 mature miRNAs, we analysed the profiles of archived normal breast epithelium, LCIS lesions found alone, LCIS lesions concurrent with ILC, and the concurrent ILCs as a model of linear histological progression towards ILC. We identified two sets of differentially expressed miRNAs, the first set highly expressed in normal epithelium, including hsa-miR-224, -139, -10b, -450, 140, and -365, and the second set up-regulated during lobular neoplasia progression, including hsa-miR-375, -203, -425-5p, -183, -565, and -182. Using quantitative RT-PCR, we validated a trend of increasing expression for hsa-miR-375, hsa-miR-182, and hsa-miR-183 correlating with ILC progression. As we detected increased expression of hsa-miR-375 in LCIS lesions synchronous with ILC, we sought to determine whether hsa-miR-375 might induce phenotypes reminiscent of lobular neoplasia by expressing it in the MCF-10A 3D culture model of mammary acinar morphogenesis. Increased expression of hsa-miR-375 resulted in loss of cellular organization and acquisition of a hyperplastic phenotype. These data suggest that dysregulated miRNA expression contributes to lobular neoplastic progression.

PMID: 21953071 [PubMed - indexed for MEDLINE]

Permalink for 'Korean Men Smokers with No Intratumoral Heterogeneity of Lung Adenocarcinomas: Correlation with Histologic Subtypes, EGFR/TTF-1 Expressions, and Clinical Features.'

Korean Men Smokers with No Intratumoral Heterogeneity of Lung Adenocarcinomas: Correlation with Histologic Subtypes, EGFR/TTF-1 Expressions, and Clinical Features.

Fetched: January 16th, 2012, 10:00pm MST

Korean Men Smokers with No Intratumoral Heterogeneity of Lung Adenocarcinomas: Correlation with Histologic Subtypes, EGFR/TTF-1 Expressions, and Clinical Features.

J Thorac Oncol. 2012 Jan 10;

Authors: Sun PL, Seol H, Lee HJ, Yoo SB, Kim H, Xu X, Jheon S, Lee CT, Lee JS, Chung JH

Abstract
INTRODUCTION: Epidermal growth factor receptor (EGFR) mutation has been known to be associated with adenocarcinoma with bronchioloalveolar carcinoma (BAC; lepidic) feature. This study was aimed to characterize the frequency of EGFR mutations and their association with histologic subtypes in Korean nonsmall cell lung cancer (NSCLC) patients. METHODS: Three hundred eighty-two (88 biopsies and 294 resections) NSCLC patients were investigated for EGFR mutations (exons 18-21) by polymerase chain reaction and direct sequencing method. For the resected adenocarcinoma specimens, histologic subtypes were classified according to both 2004 World Health Organization classification and 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. The results were correlated with EGFR mutation and clinicopathologic features. RESULTS: EGFR mutations were detected in 196 of 382 NSCLCs (51.3%) and were more frequent in women than in men (65.7% versus 34.3%, p < 0.001) and in nonsmokers than in smokers (63.4% versus 32.0%, p < 0.001). Regarding histologic subtypes of adenocarcinoma, mixed acinar and BAC pattern showed the most frequent EGFR mutation (67.6%), followed by mixed papillary and acinar (65.2%), mixed solid and acinar (38.2%), micropapillary and acinar (30.4%), and acinar and mucinous BAC (13.3%). In addition, EGFR mutations were more frequently observed in tumors with BAC or papillary components than those with mucinous BAC or solid components. Identical EGFR mutations were detected in a single tumor showing mixed histological features. EGFR protein expression was seen more frequently in tumors with EGFR mutations than those without EGFR mutations (75.3% versus 24.7%, p = 0.003). EGFR mutations were significantly more common in tumors with thyroid transcription factor-1 (TTF-1) expression than those without TTF-1 (p < 0.001), and almost all (92.7%) mutated adenocarcinomas were TTF-1 positive. CONCLUSIONS: The incidence of EGFR mutations is variable according to histologic subtypes, gender, and smoking history. The mixed acinar and BAC and papillary and acinar subtypes, the presence of BAC (lepidic) or papillary components, EGFR, and TTF-1 protein expression can predict higher EGFR mutation in lung adenocarcinoma. However, intratumoral heterogeneity of EGFR mutation was not found. In addition, relatively high incidence of EGFR mutations in Korean men who smoked with adenocarcinoma histology suggests that these patients should not be left behind EGFR mutation test.

PMID: 22237264 [PubMed - as supplied by publisher]

Acinar cell carcinoma of the pancreas: a possible role of s-1 as chemotherapy for acinar cell carcinoma. A case report.

Fetched: January 13th, 2012, 10:00pm MST

Acinar cell carcinoma of the pancreas: a possible role of s-1 as chemotherapy for acinar cell carcinoma. A case report.

JOP. 2012 Jan;13(1):87-90

Authors: Yamamoto T, Ohzato H, Fukunaga M, Imamura H, Furukawa H

Abstract
Context Acinar cell carcinoma of the pancreas is a rare malignancy, accounting for 1-2% of pancreatic exocrine malignancies. This rarity makes it difficult to standardize a protocol of treatment for acinar cell carcinoma. Case report A 71-year-old male without any particular past history was referred to our institute with abdominal distention and mild liver dysfunction. Computed tomography (CT) revealed a cystic lesion with a diameter of 3.5 cm, which originated from the neck of pancreas and had solid nodules inside. Several nodules were demonstrated surrounding the cystic tumor. Laparotomy and histological study demonstrated peritoneal dissemination of acinar cell carcinoma. The patient was treated with S-1 monotherapy (80 mg/m2 for four weeks with a two-week interval as one cycle). After one cycle of S-1 monotherapy, CT demonstrated remarkable shrinkage of the main tumor and disappearance of the nodules on the peritoneum. The patient underwent a radical distal pancreatectomy. The patient was then treated with 16 cycles of S-1 monotherapy after the radical pancreatectomy and remains without any recurrence of the disease two years later. Conclusion Initially inoperable acinar cell carcinoma was treated by monotherapy using S-1, resulting in curative operation and two years disease free survival post operation. S-1 might be more effective on acinar cell carcinoma, rather than gemcitabine.

PMID: 22233955 [PubMed - in process]

The utility of a novel antibody in the pathological diagnosis of pancreatic acinar cell carcinoma.

Fetched: January 11th, 2012, 10:00pm MST

The utility of a novel antibody in the pathological diagnosis of pancreatic acinar cell carcinoma.

J Clin Pathol. 2012 Jan 7;

Authors: Yasumoto M, Hamabashiri M, Akiba J, Ogasawara S, Naito Y, Taira T, Nakayama M, Daicho A, Yamasaki F, Shimamatsu K, Ishida Y, Kaji R, Okabe Y, Nakashima O, Ohshima K, Nakashima M, Sata M, Yano H

Abstract
AimsAcinar cell carcinomas (ACCs) are rare tumours of the exocrine pancreas accounting for about 1-2% of all pancreatic neoplasms in adults. It is therefore difficult to come across a large number of ACC cases in a single medical institution, and only a few serial studies have been published. Since ACCs present a wide variety of morphological patterns, immunohistochemical analysis is useful. In this study, the authors established a novel monoclonal antibody 2P-1-2-1 by means of a subtractive immunisation method.MethodsImmunohistochemical staining was performed using 50 primary pancreatic tumors, including 7 ACCs, 7 neuroendocrine tumours (NETs), 5 solid-pseudopapillary neoplasms (SPNs), and 31 ductal carcinomas and organs other than the pancreas.ResultsNon-neoplastic acinar cells were stained diffusely, but epithelial cells of the pancreatic duct and the islets of Langerhans were not stained. In pancreatic tumours, all the seven ACCs were diffusely positive for the 2P-1-2-1 antibody. However, no positive staining was found in other pancreatic tumours including NETs, SPNs and ductal adenocarcinomas. The sensitivity and specificity of the 2P-1-2-1 antibody for ACCs were both 100%. In other organs studied, positive staining was observed only in the ectopic pancreas.ConclusionsIt was shown that the 2P-1-2-1 antibody specifically stained the pancreatic acinar cells and tumours of acinar cell origin, such as ACCs. Although it remains unclear at this time to which proteins the monoclonal antibody 2P-1-2-1 is directed, it is suggested to be useful for the pathological diagnosis of ACCs and for the exclusion of other pancreatic tumours.

PMID: 22228907 [PubMed - as supplied by publisher]

Reduced α-dystroglycan expression correlates with shortened patient survival in pancreatic cancer.

Fetched: January 11th, 2012, 10:00pm MST

Reduced α-dystroglycan expression correlates with shortened patient survival in pancreatic cancer.

J Surg Res. 2011 Nov;171(1):120-6

Authors: Jiang X, Rieder S, Giese NA, Friess H, Michalski CW, Kleeff J

Abstract
BACKGROUND: Deregulation of cell-matrix interactions is considered an important factor in malignant transformation. Dystroglycan forms the interface between the basement membrane and the cell membrane in epithelia by its two subunits, α- and β-dystroglycan. Aberrant expression of dystroglycan has been observed in various human cancers. Here we assessed the expression of dystroglycan in pancreatic ductal adenocarcinoma (PDAC) and analyzed its association with clinical parameters.
METHODS: mRNA levels of dystroglycan were determined by real-time quantitative PCR in tissue samples from 60 patients with PDAC, from 48 patients with CP, and from 18 healthy donors. Furthermore, pancreatic cancer specimens of 53 patients were analyzed by immunohistochemistry using specific α- and β-dystroglycan antibodies. The staining was semiquantitatively evaluated and correlated to patient survival using the Kaplan-Meier method.
RESULTS: On the mRNA level, dystroglycan was down-regulated in PDAC compared with the normal pancreas. In normal pancreatic tissues, α- and β-dystroglycans were mainly expressed on the basolateral cell membrane of acinar and ductal cells, while islet cells showed a cytoplasmatic staining. In contrast, in PDAC tissues, this membrane staining pattern was lost and replaced by a cytoplasmatic staining, suggesting impairments in the membrane translocation of both dystroglycans. Semiquantitative analysis revealed a significant inverse correlation of α- (but not β-) dystroglycan staining and postoperative survival (P=0.039).
CONCLUSION: Reduced expression and altered localization of dystroglycan is common in PDAC, potentially contributing to the aggressive behavior of this disease.

PMID: 20338590 [PubMed - indexed for MEDLINE]

Histological variants of prostatic carcinoma and their significance.

Fetched: January 5th, 2012, 10:00pm MST

Histological variants of prostatic carcinoma and their significance.

Histopathology. 2012 Jan;60(1):59-74

Authors: Humphrey PA

Abstract
Humphrey P A (2012) Histopathology60, Histological variants of prostatic carcinoma and their significance The vast majority of prostatic cancers are acinar adenocarcinomas. Histological variants of prostatic carcinoma have been variably defined. One approach is to consider two groups of variants. The first group comprises histological variants of acinar adenocarcinoma and the second group non-acinar carcinoma variants or types. Variants of usual acinar adenocarcinoma defined in 2004 by the World Health Organization (WHO) include atrophic, pseudohyperplastic, foamy, colloid, signet ring, oncocytic and lymphoepithelioma-like carcinomas. The second group of non-acinar carcinoma histological variants or types of prostatic carcinoma accounts for about 5-10% of carcinomas that originate in the prostate. These include sarcomatoid carcinoma, ductal adenocarcinoma, urothelial carcinoma, squamous and adenosquamous carcinoma, basal cell carcinoma, and neuroendocrine tumours, specifically small-cell carcinoma. Recently characterized variants not present in the 2004 WHO classification, including microcystic adenocarcinoma, prostatic intraepithelial neoplasia-like adenocarcinoma, large-cell neuroendocrine carcinoma, and pleomorphic giant cell carcinoma, are also described. The aims of this review are to present the essential histomorphological diagnostic attributes of these variants, and to emphasize the clinical signficance of the variants, when different from usual acinar adenocarcinoma, including clinical presentation and outcome.

PMID: 22212078 [PubMed - in process]

Precursors of prostate cancer.

Fetched: January 5th, 2012, 10:00pm MST

Precursors of prostate cancer.

Histopathology. 2012 Jan;60(1):4-27

Authors: Bostwick DG, Cheng L

Abstract
Bostwick D G & Cheng L (2012) Histopathology 60, 4-27 Precursors of prostate cancer High-grade prostatic intraepithelial neoplasia (PIN) is the only accepted precursor of prostatic adenocarcinoma, according to numerous studies of animal models and man; other proposed precursors include atrophy and malignancy-associated changes (with no morphologic changes). PIN is characterized by progressive abnormalities of phenotype and genotype that are intermediate between benign prostatic epithelium and cancer, indicating impairment of cell differentiation and regulatory control with advancing stages of prostatic carcinogenesis. The only method of detection of PIN is biopsy because it does not significantly elevate serum prostate-specific antigen concentration and cannot be detected by ultrasonography. The mean incidence of PIN in biopsies is 9% (range, 4%-16%), representing about 115 000 new cases of isolated PIN diagnosed each year in the United States. The clinical importance of PIN is its high predictive value as a marker for adenocarcinoma, and its identification warrants repeat biopsy for concurrent or subsequent carcinoma, especially when multifocal or observed in association with atypical small acinar proliferation (ASAP). Carcinoma develops in most patients with PIN within 10 years. Androgen deprivation therapy and radiation therapy decrease the prevalence and extent of PIN, suggesting that these forms of treatment may play a role in prevention of subsequent cancer. Multiple clinical trials to date of men with PIN have had modest success in delaying or preventing subsequent cancer.

PMID: 22212075 [PubMed - in process]

Ectopic adrenocorticotrophic hormone syndrome associated with poor prognosis in metastatic parotid acinic cell carcinoma.

Fetched: December 29th, 2011, 10:00pm MST

Ectopic adrenocorticotrophic hormone syndrome associated with poor prognosis in metastatic parotid acinic cell carcinoma.

Otolaryngol Head Neck Surg. 2011 Nov;145(5):878-9

Authors: Shenoy VV, Lwin Z, Morton A, Hardy J

PMID: 21540317 [PubMed - indexed for MEDLINE]

Permalink for 'Adenocarcinomas With Prominent Lepidic Spread: Retrospective Review Applying New Classification of the American Thoracic Society.'

Adenocarcinomas With Prominent Lepidic Spread: Retrospective Review Applying New Classification of the American Thoracic Society.

Fetched: December 28th, 2011, 10:00pm MST

Adenocarcinomas With Prominent Lepidic Spread: Retrospective Review Applying New Classification of the American Thoracic Society.

Am J Surg Pathol. 2011 Dec 23;

Authors: Xu L, Tavora F, Battafarano R, Burke A

Abstract
BACKGROUND:: Recently, a new classification of lung adenocarcinomas has been proposed for tumors with lepidic spread. The greatest diameter of the invasive component determines minimally invasive cancers, and the term bronchioloalveolar carcinoma is no longer used. METHODS:: We retrospectively reviewed 87 resected adenocarcinomas of the lung; 30 tumors with lepidic growth and without high-grade invasive areas were identified, and the invasive component was measured morphometrically and categorized. A dimension of 5 mm was the cutoff for invasion. Regional lymph node involvement and short-term follow-up were compared among subtypes of these well-differentiated and moderately differentiated adenocarcinomas. RESULTS:: There were 11 well-differentiated adenocarcinomas with lepidic growth: 3 adenocarcinomas in situ (nonmucinous) and 8 minimally invasive adenocarcinomas (MIAs) (4 mucinous and 4 nonmucinous). There were 19 invasive moderately differentiated adenocarcinomas with a prominent lepidic growth pattern (LPAs). The mean size of the 3 adenocarcinomas in situ cases was 0.9±0.7 mm; the total size of the 8 MIA cases was 1.4±1.8 cm and that of the 19 LPA cases was 3.2±2.1 cm. The invasive size of the MIA was 0.3±0.6 and that of the LPA was 2.2±0.3. The invasive pattern of the LPAs was papillary and acinar without desmoplasia (n=3) and acinar with desmoplasia (n=16). Seven of the invasive desmoplastic tumors showed complex single-cell invasion or lymphatic invasion. Identification of the transition from lepidic to invasive acinar was straightforward because of the presence of elastotic desmoplasia. The transition between complex acinar papillary invasion and lepidic growth was often difficult to discern. Lymph node metastases were present in 5 cases (26%), all in tumors with an acinar, desmoplastic invasive component of >1 cm, with areas of single-cell invasion. With follow-up, progressive nodal involvement or distant metastases occurred in 4 patients, all with complex invasive patterns; 3 with invasion >1 cm and 1 with lymphatic invasion in smaller invasive tumors. Recurrent lung nodules occurred in 5 patients, including 1 patient with MIA, 1 with nondesmoplastic invasion, 2 with desmoplastic invasion, and 1 with complex desmoplastic invasion. CONCLUSIONS:: Approximately one third of lung adenocarcinomas have significant lepidic spread, and of these nearly one third are minimally invasive. Measurement of the invasive component may be difficult without elastotic desmoplasia. In this small series, lymph node and distant metastases occurred only in those with complex invasive patterns, but lung recurrence occurred in all subtypes, including MIAs.

PMID: 22198010 [PubMed - as supplied by publisher]

Acinar cell carcinoma of the pancreas: a case report and review of the literature.

Fetched: December 25th, 2011, 10:00pm MST

Acinar cell carcinoma of the pancreas: a case report and review of the literature.

Acta Chir Belg. 2011 Sep-Oct;111(5):319-22

Authors: Karagianopoulou G, Noussios G, Katsourakis A, Karavalaki M, Tzegas S, Chatzitheoklitos E

Abstract
The majority of pancreatic malignant tumours are adenocarcinomas of the ductal type, whereas acinar cell carcinoma (ACC) is unusual. Its management is not well codified, resulting from its low frequency. It seems however that curative operative resection represents the best first-line treatment. We present a case of ACC in a 54-year-old woman who presented with right upper quadrant pain of the abdomen due to a pancreatic mass in the head of the pancreas, detected by computer tomography (CT) and magnetic resonance imaging (MRI). In April 2008 the patient underwent a pancreatoduodenectomy (Longmire-Traverso) and received postoperative chemotherapy. We present a case of pancreatic ACC treated with a curative operation followed by chemotherapy. Our patient remains free of the disease and has a good quality of life.

PMID: 22191136 [PubMed - in process]

Pulmonary acinic cell carcinoma (Fechner tumour) with carcinoid component. A case report.

Fetched: December 24th, 2011, 10:00pm MST

Pulmonary acinic cell carcinoma (Fechner tumour) with carcinoid component. A case report.

Pol J Pathol. 2011 Jun;62(2):105-7

Authors: Papla B, Czajkowski W, Kocoń P, Ryś J

Abstract
The authors present a very rare case of primary lung acinic cell carcinoma with carcinoid component in a 53-year-old man.

PMID: 21866467 [PubMed - indexed for MEDLINE]

The lipid kinase PI4KIIIβ and the eEF1A2 oncogene co-operate to disrupt three-dimensional in vitro acinar morphogenesis.

Fetched: December 21st, 2011, 10:00pm MST

The lipid kinase PI4KIIIβ and the eEF1A2 oncogene co-operate to disrupt three-dimensional in vitro acinar morphogenesis.

Exp Cell Res. 2011 Oct 15;317(17):2503-11

Authors: Pinke DE, Lee JM

Abstract
The study of in vitro morphogenesis is fundamental to understanding neoplasia since the dysregulation of morphogenic pathways that create multi-cellular organisms is a common hallmark of oncogenesis. The in vitro culture of human breast epithelial cells on reconstituted basement membranes recapitulate some features of in vivo breast development, including the formation of a three-dimensional structure termed an acinus. Importantly, the capacity to disrupt in vitro acinar morphogenesis is a common property of human breast oncogenes. In this report, we find that phosphatidylinositol 4-kinase IIIβ (PI4KIIIβ), a lipid kinase that phosphorylates phosphatidylinositol (PI) to PI(4)P, disrupts in vitro mammary acinar formation. The PI4KIIIβ protein localizes to the basal surface of acini created by human MCF10A cells and ectopic expression of PI4KIIIβ induces multi-acinar devlopment. Furthermore, expression of an oncogenic PI4KIIIβ activator, eEF1A2 (eukaryotic elongation factor 1 alpha 2), phenocopies the PI4KIIIβ multi-acinar phenotype. Ectopic expression of PI4KIIIβ or eEF1A2 alters the localization of PI(4)P and PI(4,5)P(2) within acini, indicating the importance of these lipids in acinar development. Our work shows that PI4KIIIβ, eEF1A2 and PI(4)P likely play an important role in mammary neoplasia and acinar development.

PMID: 21851817 [PubMed - indexed for MEDLINE]

Permalink for 'Does lung adenocarcinoma subtype predict patient survival?: A clinicopathologic study based on the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary lung aden'

Does lung adenocarcinoma subtype predict patient survival?: A clinicopathologic study based on the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary lung aden

Fetched: December 21st, 2011, 10:00pm MST

Does lung adenocarcinoma subtype predict patient survival?: A clinicopathologic study based on the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary lung adenocarcinoma classification.

J Thorac Oncol. 2011 Sep;6(9):1496-504

Authors: Russell PA, Wainer Z, Wright GM, Daniels M, Conron M, Williams RA

Abstract
INTRODUCTION: Lung adenocarcinoma is a heterogeneous group of tumors with a highly variable prognosis, not well predicted by the current pathologic classification system. The 2004 World Health Organization classification results in virtually all tumors encountered in clinical practice being allocated to the adenocarcinoma of mixed subtype category. A new classification developed by an international multidisciplinary expert panel sponsored by the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society, is based on histomorphologic subtype and has recently been validated in a North American series of 514 stage I lung adenocarcinomas. We investigated the relationship between the new classification and patient survival in a series of Australian patients with stages I, II, and III lung adenocarcinoma.
METHODS: We identified 210 patients from a surgical database who underwent resection of lung adenocarcinoma from 1996 to 2009. Two pathologists, blinded to patient outcome, independently performed histopathologic subtyping according to the new classification. Kaplan-Meier curves were used to calculate 5-year survival for each separate histopathologic subtype/variant. Univariate and multivariate analyses were undertaken to control for validated prognostic factors.
RESULTS: We confirmed that the new subtypes of adenocarcinoma in situ, minimally invasive adenocarcinoma and lepidic-predominant adenocarcinoma had a 5-year survival approaching 100%, whereas micropapillary-predominant and solid with mucin-predominant adenocarcinomas were associated with particularly poor survival. Papillary-predominant and acinar-predominant adenocarcinomas had an intermediate prognosis. This effect persisted after controlling for stage.
CONCLUSIONS: Classification of lung adenocarcinoma according to the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification correlated with 5-year survival. These relationships persisted after controlling for known prognostic patient and tumor characteristics. The new classification has advantages not only for individual patient care but also for better selection and stratification for clinical trials and molecular studies.

PMID: 21642859 [PubMed - indexed for MEDLINE]

Sclerosing polycystic adenosis of the submandibular gland.

Fetched: December 20th, 2011, 10:00pm MST

Sclerosing polycystic adenosis of the submandibular gland.

Acta Otorrinolaringol Esp. 2011 Dec 12;

Authors: Beato Martínez A, Moreno Juara A, Candia Fernández A

Abstract
Sclerosing polycystic adenosis (SPA) is a rare, newly-reported lesion of the salivary glands. Most cases occurred within mayor salivary glands and were frequently confused with other salivary gland carcinomas such as acinar cell carcinoma. We report a case of SPA within the submandibular gland in a 63-year-old woman.

PMID: 22169590 [PubMed - as supplied by publisher]

From tissue turnover to the cell of origin for pancreatic cancer.

Fetched: December 20th, 2011, 10:00pm MST

From tissue turnover to the cell of origin for pancreatic cancer.

Nat Rev Gastroenterol Hepatol. 2011 Aug;8(8):467-72

Authors: Kong B, Michalski CW, Erkan M, Friess H, Kleeff J

Abstract
The identity of the cell of origin for pancreatic ductal adenocarcinoma (PDAC) has long been debated. PDAC has a ductal morphology, but there is no formal proof that it originates from the ductal compartment. Targeting Kras expression to adult acinar or endocrine lineages induces the formation of tumors reminiscent of human PDAC, but only in the presence of concomitant inflammation. Apart from cells of the Pdx1-positive lineage in the adult pancreas, which can be transformed (albeit with low frequency), the cells susceptible to acquiring or retaining oncogenic mutations remain elusive. Hypothetically, a subset of cells that renew the adult organ physiologically or regenerate it upon severe tissue damage would be more susceptible to oncogenic transformation than mature, differentiated cells. Such a compartment could consist of putative pancreatic stem cells, progenitor cells, facultative stem cells or transdifferentiated bone marrow cells. An integrated approach combining techniques from stem cell and cancer biology will be necessary to define and map these cells.

PMID: 21750515 [PubMed - indexed for MEDLINE]

Permalink for 'MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease.'

MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease.

Fetched: December 20th, 2011, 10:00pm MST

MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease.

AJNR Am J Neuroradiol. 2011 Aug;32(7):1202-7

Authors: Christe A, Waldherr C, Hallett R, Zbaeren P, Thoeny H

Abstract
BACKGROUND AND PURPOSE: The surgical approach to parotid tumors is different for benign and malignant neoplasms, but the clinical symptoms do not correlate well with histology. Difficulties in tumor classification also arise in imaging modalities, in which sonography has the lowest and MR imaging, the highest accuracy. The purpose of this study was to review our experience using conventional MR imaging of the neck in the evaluation of parotid tumors and to evaluate which MR imaging findings are best able to predict malignant histology.
MATERIALS AND METHODS: Eighty-four consecutive patients (43 males, 41 females; median age, 56 years; range, 9-85 years) with parotid gland tumors who underwent MR imaging before surgery were prospectively included in the present study and retrospectively analyzed. Histology was available for all tumors. We analyzed the following MR imaging parameters: signal intensity, contrast enhancement, lesion margins (well-defined versus ill-defined), lesion location (deep/superficial lobe), growth pattern (focal, multifocal, or diffuse), and extension into neighboring structures, perineural spread, and lymphadenopathy.
RESULTS: The 57 (68%) benign and 27 (32%) malignant tumors consisted of 29 pleomorphic adenomas, 17 Warthin tumors, 11 various benign tumors, 5 mucoepidermoid carcinomas, 3 adenoid cystic carcinomas, 1 acinic cell carcinoma, 1 carcinoma ex pleomorphic adenoma, 9 metastases, and 8 various malignant neoplasms. Specific signs predictive of malignancy were the following: T2 hypointensity of the parotid tumor (P = .048), ill-defined margins (P = .001), diffuse growth (P = .012), infiltration of subcutaneous tissue (P = .0034), and lymphadenopathy (P = .012).
CONCLUSIONS: Low signal intensity on T2-weighted images and postcontrast ill-defined margins of a parotid tumor are highly suggestive of malignancy.

PMID: 21724574 [PubMed - indexed for MEDLINE]

Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs.

Fetched: December 20th, 2011, 10:00pm MST

Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs.

Lung Cancer. 2011 Aug;73(2):176-82

Authors: Chung JH, Rho JK, Xu X, Lee JS, Yoon HI, Lee CT, Choi YJ, Kim HR, Kim CH, Lee JC

Abstract
BACKGROUND: Epithelial-to-mesenchymal transition (EMT), which was related with an acquired resistance to gefitinib, was found in the A549 lung cancer cell line. However, the clinical feasibility of this finding is still questionable. Here, we investigated whether EMT could be detected in a more clinically suitable situation using patient's tumor and cells with deletion mutation on exon 19 of EGFR gene.
METHODS: HCC827 cell line was used to establish the subline resistant to EGFR-TKIs. The induction of EMT was analyzed by immunostainings and Western blots in resistant cells and biopsied tissue from a patient with acquired resistance to erlotinib. Migration and invasion assay was performed to characterize the resistant cells. EMT-related genes expression was evaluated by cDNA microarray. Phospho-receptor tyrosine kinase array analysis was carried out to find bypass activating signals such as MET.
RESULTS: We found that EMT developed in a lung cancer patient who had an acquired resistance to erlotinib while there were no known resistant mechanisms such as T790M and MET amplification. CL-387,785-resistant cells (HCC827/CLR) were obtained by long-term exposure to increasing concentrations of CL-387,785 (an irreversible EGFR-TKI). The morphological and molecular maker changes compatible with EMT were also found in HCC827/CLR cells. However, there were also no secondary T790M mutation and MET amplification. Furthermore, the activity of most of tested RTKs including receptor HER family was decreased suggesting that there was no bypass activating signal leading to resistance. These cells showed an enhanced capability for migration (∼1.6-fold) and invasion (∼2.8-fold).
CONCLUSION: EMT should be considered as one of possible mechanisms for the acquired resistance to EGFR-TKIs in lung cancer cells.

PMID: 21168239 [PubMed - indexed for MEDLINE]

Permalink for 'Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic kras in the nestin cell lineage.'

Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic kras in the nestin cell lineage.

Fetched: December 8th, 2011, 10:00pm MST

Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic kras in the nestin cell lineage.

PLoS One. 2011;6(11):e27725

Authors: Carrière C, Young AL, Gunn JR, Longnecker DS, Korc M

Abstract
Targeting of oncogenic Kras to the pancreatic Nestin-expressing embryonic progenitor cells and subsequently to the adult acinar compartment and Nestin-expressing cells is sufficient for the development of low grade pancreatic intraepithelial neoplasia (PanIN) between 2 and 4 months. The mice die around 6 month-old of unrelated causes, and it is therefore not possible to assess whether the lesions will progress to carcinoma. We now report that two brief episodes of caerulein-induced acute pancreatitis in 2 month-old mice causes rapid PanIN progression and pancreatic ductal adenocarcinoma (PDAC) development by 4 months of age. These events occur with similar frequency as observed in animals where the oncogene is targeted during embryogenesis to all pancreatic cell types. Thus, these data show that oncogenic Kras-driven PanIN originating in a non-ductal compartment can rapidly progress to PDAC when subjected to a brief inflammatory insult.

PMID: 22140463 [PubMed - in process]

Re-Evaluating Historic Cohort of Salivary Acinic Cell Carcinoma with New Diagnostic Tools.

Fetched: December 3rd, 2011, 10:00pm MST

Re-Evaluating Historic Cohort of Salivary Acinic Cell Carcinoma with New Diagnostic Tools.

Head Neck Pathol. 2011 Nov 30;

Authors: Lei Y, Chiosea SI

Abstract
Mammary analogue secretory carcinoma (MASC) was recently identified as a distinct salivary gland neoplasm, morphologically resembling intercalated duct cell predominant acinic cell carcinoma (AciCC). To determine how frequently MASC has mimicked an intercalated duct cell predominant AciCC, we reviewed AciCC diagnosed from 1956 to 1975. Nine AciCC consecutively diagnosed in that period were identified. Based on morphologic examination, one case diagnosed as AciCC in a male patient in 1960 was re-classified as MASC [confirmed by fluorescence in situ hybridization (FISH) showing ETV6 translocation]. Another case diagnosed as AciCC of the palate in a female patient in 1975 was re-classified as mucoepidermoid carcinoma (based on the lack of acinar differentiation, presence of mucous cells, and confirmed by FISH showing MAML2 translocation). In this proof-of-principle study, we show that 1 in 9 cases historically designated as AciCC represents a MASC. "Intercalated duct cell predominant AciCC", especially among male patients, most likely represent examples of MASC. For anatomic sites outside of the parotid glands, broader differential diagnoses should be considered before accepting morphologic variants of AciCC as the final diagnosis.

PMID: 22127547 [PubMed - as supplied by publisher]

Glypican-3 as a potential differential diagnosis marker for hepatocellular carcinoma: A tissue microarray-based study.

Fetched: December 1st, 2011, 10:00pm MST

Glypican-3 as a potential differential diagnosis marker for hepatocellular carcinoma: A tissue microarray-based study.

Acta Histochem. 2011 Nov 24;

Authors: Zhang L, Liu H, Sun L, Li N, Ding H, Zheng J

Abstract
The differential diagnosis between hepatocellular carcinoma (HCC) and benign hepatic lesions is still difficult and new biochemical markers for HCC are required. The aim of this study was to assess the differential diagnostic value of glypican-3 (GPC3) immunostaining in HCC patients. 147 cases of surgically excised HCC tissues, 94 cases from needle biopsies, and tissue microarrays were used for this study. The tissue microarrays contained 449 specimens including: 115 HCC, 25 intrahepatic cholangiocellular carcinoma, 29 lung adenocarcinoma, 23 squamous cell lung carcinoma, 53 ovary adenocarcinoma, 44 renal cell carcinoma, 30 prostate acinar adenocarcinoma, 42 breast carcinoma, 41 gastric carcinoma and 47 colorectal carcinoma. The immunolocalization of GPC3 was measured using immunohistochemical staining. Among 147 surgically excised HCC samples, 87.1% (128/147) were GPC3 positive. No GPC3 expression, however, was observed in paracarcinomatous and cirrhotic tissues. In needle biopsy tissues, GPC3 was positively expressed in 81.9% (77/94). Among tissue microassays, HCCs showed positive GPC3 expression in 55.7% (64/115), while 9.6% (5/52) of lung carcinoma and 5.7% (3/53) of ovary adenocarcinoma also were positively stained. The other tumor types showed negative GPC3 expression. In conclusion, our results show that GPC3 is specifically overexpressed in HCC tissue and may be regarded as a potential marker for differential diagnostic hepatocellular carcinoma.

PMID: 22119409 [PubMed - as supplied by publisher]

Review of small cell carcinomas of the prostate.

Fetched: November 29th, 2011, 10:00pm MST

Review of small cell carcinomas of the prostate.

Prostate Cancer. 2011;2011:543272

Authors: Furtado P, Lima MV, Nogueira C, Franco M, Tavora F

Abstract
Small cell carcinoma of the prostate is a rare neoplasm, with only a few series hitherto reported. A little less than half of the cases are associated with conventional acinar adenocarcinoma, which are usually high grade. Although consensus has not been reached, the majority of patients with small cell neuroendocrine carcinoma of the prostate have advanced disease at diagnosis and disproportionally low PSA levels compared to patients with conventional acinar adenocarcinoma. Treatment consists mainly of chemotherapy associated with surgery. Radiation therapy is reserved for selected cases. This study reviews the most up-to-date information on small cell carcinomas of the prostate.

PMID: 22110988 [PubMed - in process]

Acinar cell carcinoma with fatty change arising from the pancreas.

Fetched: November 29th, 2011, 10:00pm MST

Acinar cell carcinoma with fatty change arising from the pancreas.

Br J Radiol. 2011 Dec;84(1008):e226-8

Authors: Chung WS, Park MS, Kim DW, Kim KW

Abstract
Acinar cell carcinoma of the pancreas is a rare malignant tumour developing from acinar cells, accounting for approximately 1% of pancreatic exocrine tumours. We experienced a case of an acinar cell carcinoma with fatty change. To the best of our knowledge, this is the first case report of an acinar cell carcinoma with fatty change in the clinical literature.

PMID: 22101587 [PubMed - in process]

Claudin-18 is an early-stage marker of pancreatic carcinogenesis.

Fetched: November 17th, 2011, 10:00pm MST

Tags: claudin

Claudin-18 is an early-stage marker of pancreatic carcinogenesis.

J Histochem Cytochem. 2011 Oct;59(10):942-52

Authors: Tanaka M, Shibahara J, Fukushima N, Shinozaki A, Umeda M, Ishikawa S, Kokudo N, Fukayama M

Abstract
Pancreatic ductal neoplasms exhibit gastric epithelium-like characteristics. In this study, we evaluated the expression of claudin-18 (CLDN18), a gastric epithelium-associated claudin, in pancreatic intraepithelial neoplasias (PanINs), intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCNs), and pancreatic ductal adenocarcinomas (PDACs) using immunohistochemistry. We observed a high level of expression of CLDN18 in PanINs (31/32, 97%), IPMNs (61/65, 95%), and MCNs (4/5, 80%) using ordinary tissue section analysis. Furthermore, we observed a high level of CLDN18 expression in PDACs (109/156, 70%) using tissue microarray analysis. However, the normal pancreatic duct or the ductal metaplasia of the acinar cells was not immunoreactive. Comparative analysis of CLDN18 and phenotypic markers in IPMNs revealed that simultaneous expression of CLDN18 and intestinal markers frequently occurred, even in intestinal-type IPMNs. CLDN18 variant 2 mRNA was expressed and was similarly upregulated by phorbol 12-myristate 13-acetate (PMA) treatment in pancreatic cancer cell lines and in a gastric cancer cell line. An inhibitor of pan-PKC (GF109203X) completely suppressed this upregulation in pancreatic cancer cells. These results indicate that CLDN18, a marker for the early carcinogenetic process, is commonly expressed in precursor lesions of PDAC. Activation of the PKC pathway might be involved in CLDN18 expression associated with pancreatic carcinogenesis.

PMID: 21832145 [PubMed - indexed for MEDLINE]

Acinar Cell Carcinoma Responding to Carboplatin/Etoposide Chemotherapy.

Fetched: November 10th, 2011, 10:00pm MST

Acinar Cell Carcinoma Responding to Carboplatin/Etoposide Chemotherapy.

J Gastrointest Cancer. 2011 Nov 8;

Authors: Sorscher SM

PMID: 22058048 [PubMed - as supplied by publisher]

[Acinic cell carcinoma in an ectopic salivary gland].

Fetched: November 10th, 2011, 10:00pm MST

[Acinic cell carcinoma in an ectopic salivary gland].

Rev Laryngol Otol Rhinol (Bord). 2010;131(4-5):299-302

Authors: Tavernier L, Godon A, Algros MP, Rainfaing E, Chobaut JC

Abstract
On the occasion of the coverage of a cervical tumefaction in a child, which led to the diagnosis of acinic cell carcinoma of ectopic salivary gland, the authors conducted a literature review of this tumour. If it is well known to pathologists when it is developed in the major or accessories salivary glands, its location within heterotopy of salivary tissue is much rarer. From a histological point of view it is difficult to distinguish, if primitive location, the occurrence of the tumour in an ectopic salivary gland, its occurrence in intra-node heterotopic salivary tissue. This distinction between glandular ectopia and intra-node heterotopia remains purely theoretical, and does not affect the therapeutic decision. This one remains empirical and discussed on a case-by-case basis for a malignant tumour that is exceptional in this location and at that age.

PMID: 21866744 [PubMed - indexed for MEDLINE]

Acinar Cell Carcinoma of the Pancreas: New Genetic and Treatment Insights into a Rare Malignancy.

Fetched: November 5th, 2011, 11:00pm MDT

Acinar Cell Carcinoma of the Pancreas: New Genetic and Treatment Insights into a Rare Malignancy.

Oncologist. 2011 Oct 31;

Authors: Lowery MA, Klimstra DS, Shia J, Yu KH, Allen PJ, Brennan MF, O'Reilly EM

Abstract
AbstractBackground. Acinar cell carcinoma (ACC) of the pancreas is a rare neoplasm, accounting for 1% of all pancreatic neoplasms. There remains a lack of data regarding the use of systemic therapy in this disease. We present a series of 40 consecutive cases of ACC of the pancreas treated at Memorial Sloan-Kettering Cancer Center, with an emphasis on evaluation of activity of new therapeutic agents.Methods. Patients reviewed at our institution from January 2000 through January 2011 were identified from an institutional database with prior institutional review board approval. Pathology was confirmed in all cases as ACC or a closely related entity.Results. Forty patients were identified; 29 were male (73%). The median age at diagnosis was 65 years (range, 16-87 years). The median overall survival (OS) time for patients with localized, resectable disease was 56.9 months and the OS time for patients with metastatic ACC (n = 18) was 19.6 months. Six patients with metastatic or recurrent ACC had a partial response to chemotherapy and five patients had stable disease for ≥6 months on systemic chemotherapy. Clinical observation was made of a patient with ACC and hereditary nonpolyposis colorectal cancer and a patient with ACC and a BRCA1 germline mutation.Conclusions. ACC is moderately chemoresponsive to agents that have activity in pancreatic adenocarcinoma and colorectal carcinoma. A potential association between germline mutations in DNA mismatch repair genes and ACC warrants further evaluation.

PMID: 22042785 [PubMed - as supplied by publisher]

Review of small cell carcinomas of the prostate - Abstract - UroToday

Posted: January 8th, 2012, 9:11pm MST

Newport's Andrew Rodman -- surfer, poet and editor -- reaches into his beliefs ... - OregonLive.com

Posted: November 29th, 2011, 1:42pm MST

OregonLive.com

Cancer diagnosis changes outlook for Podlesh - Rochester Democrat and Chronicle

Posted: November 13th, 2011, 1:34am MST

Brush with cancer gives Bears punter Podlesh whole new perspective - Winnipeg Free Press

Posted: November 12th, 2011, 3:03am MST

Cancer scare gives Podlesh whole new outlook - Washington Examiner

Posted: November 11th, 2011, 8:02pm MST

Washington Examiner

Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity.

Fetched: January 22nd, 2012, 10:00pm MST

Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity.

J Pathol. 2012 Jan;226(1):108-19

Authors: Giricz O, Reynolds PA, Ramnauth A, Liu C, Wang T, Stead L, Childs G, Rohan T, Shapiro N, Fineberg S, Kenny PA, Loudig O

PMID: 21953071 [PubMed - indexed for MEDLINE]

Long-term treatment outcome of minor salivary gland carcinoma of the hard palate.

Fetched: January 19th, 2012, 10:00pm MST

Long-term treatment outcome of minor salivary gland carcinoma of the hard palate.

Oral Oncol. 2012 Jan 14;

Authors: Li Q, Zhang XR, Liu XK, Liu ZM, Liu WW, Li H, Guo ZM

Abstract
Minor salivary gland carcinoma of the hard palate is rare, and its long-term survival rate is high, making it difficult to evaluate the prognostic factors and the efficacy of treatment. This study was designed to evaluate the treatment outcome of minor salivary gland carcinoma of the hard palate. 103 cases of minor salivary gland carcinoma of the hard palate treated with surgery alone or underwent surgery combined with post-operative radiotherapy hospitalized in Cancer Center, Sun Yet-Sen University, from 1968 to 2008 were reviewed retrospectively. The most common histologic types were adenoid cystic carcinoma in 48 patients(46.6%), mucoepidermoid carcinoma in 37(35.92%), malignant mixed tumor in 15(14.56%), and acinic cell carcinoma in 3(2.91%). The median follow-up time was 74.83months (range 0.9-356.57months). Overall outcomes at 5 and 10years were overall survival (OS), 77.9% and 65.7%; recurrence-free survival (RFS), 64.4% and 53.2%; and disease specific survival (DSS), 77.9% and 67.7%, respectively. There was no significant difference in overall survival (P=0.52), recurrence-free survival (P=0.762) and disease specific survival (P=0.449) between patients who underwent surgery alone and those who underwent surgery plus post-operative radiotherapy. Surgery has been accepted as the primary treatment for minor salivary gland carcinoma of hard palate. Sufficient surgical excision with adequate margins is essential for a favorable outcome. We advocate using radiotherapy in the post-operative context for patients with poorly differentiated, cervical lymph node metastasis, positive or close margins, and large primary lesions.

PMID: 22248739 [PubMed - as supplied by publisher]

Case report of mammary analog secretory carcinoma of the parotid gland.

Fetched: January 19th, 2012, 10:00pm MST

Case report of mammary analog secretory carcinoma of the parotid gland.

Pathol Int. 2012 Feb;62(2):149-52

Authors: Ito S, Ishida E, Skalova A, Matsuura K, Kumamoto H, Sato I

Abstract
Mammary Analog Secretory Carcinoma (MASC) is a new entity of malignant salivary gland tumors that morphologically resembles mammary secretory carcinoma and carries the identical ETV6-NTRK3 fusion gene. We report our first case of MASC in Japan occurring in the parotid gland of a 37-year-old female patient with a t (12; 15) (p13; q25) translocation. Histologically, the tumor was composed of monomorphic cuboidal cells with low-grade vesicular nuclei and pale eosinophilic cytoplasm, and formed microcystic and tubular spaces with periodic acid-Schiff-positive secretion. Immunohistochemically, the tumor cells tested positive for cytokeratin, vimentin, and S-100 protein. MASC is a morphological mimicker of acinic cell carcinoma, but is a distinct neoplasm characterized by a specific chromosomal translocation. An accumulation of similar case studies is mandatory in order to clarify biological behaviors.

PMID: 22243786 [PubMed - in process]

Permalink for 'High Incidence of EGFR Mutations in Korean Men Smokers with No Intratumoral Heterogeneity of Lung Adenocarcinomas: Correlation with Histologic Subtypes, EGFR/TTF-1 Expressions, and Clinical Features.'

High Incidence of EGFR Mutations in Korean Men Smokers with No Intratumoral Heterogeneity of Lung Adenocarcinomas: Correlation with Histologic Subtypes, EGFR/TTF-1 Expressions, and Clinical Features.

Fetched: January 19th, 2012, 10:00pm MST

High Incidence of EGFR Mutations in Korean Men Smokers with No Intratumoral Heterogeneity of Lung Adenocarcinomas: Correlation with Histologic Subtypes, EGFR/TTF-1 Expressions, and Clinical Features.

J Thorac Oncol. 2012 Feb;7(2):323-330

Authors: Sun PL, Seol H, Lee HJ, Yoo SB, Kim H, Xu X, Jheon S, Lee CT, Lee JS, Chung JH

Abstract
INTRODUCTION:: Epidermal growth factor receptor (EGFR) mutation has been known to be associated with adenocarcinoma with bronchioloalveolar carcinoma (BAC; lepidic) feature. This study was aimed to characterize the frequency of EGFR mutations and their association with histologic subtypes in Korean nonsmall cell lung cancer (NSCLC) patients. METHODS:: Three hundred eighty-two (88 biopsies and 294 resections) NSCLC patients were investigated for EGFR mutations (exons 18-21) by polymerase chain reaction and direct sequencing method. For the resected adenocarcinoma specimens, histologic subtypes were classified according to both 2004 World Health Organization classification and 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. The results were correlated with EGFR mutation and clinicopathologic features. RESULTS:: EGFR mutations were detected in 196 of 382 NSCLCs (51.3%) and were more frequent in women than in men (65.7% versus 34.3%, p < 0.001) and in nonsmokers than in smokers (63.4% versus 32.0%, p < 0.001). Regarding histologic subtypes of adenocarcinoma, mixed acinar and BAC pattern showed the most frequent EGFR mutation (67.6%), followed by mixed papillary and acinar (65.2%), mixed solid and acinar (38.2%), micropapillary and acinar (30.4%), and acinar and mucinous BAC (13.3%). In addition, EGFR mutations were more frequently observed in tumors with BAC or papillary components than those with mucinous BAC or solid components. Identical EGFR mutations were detected in a single tumor showing mixed histological features. EGFR protein expression was seen more frequently in tumors with EGFR mutations than those without EGFR mutations (75.3% versus 24.7%, p=0.003). EGFR mutations were significantly more common in tumors with thyroid transcription factor-1 (TTF-1) expression than those without TTF-1 (p < 0.001), and almost all (92.7%) mutated adenocarcinomas were TTF-1 positive. CONCLUSIONS:: The incidence of EGFR mutations is variable according to histologic subtypes, gender, and smoking history. The mixed acinar and BAC and papillary and acinar subtypes, the presence of BAC (lepidic) or papillary components, EGFR, and TTF-1 protein expression can predict higher EGFR mutation in lung adenocarcinoma. However, intratumoral heterogeneity of EGFR mutation was not found. In addition, relatively high incidence of EGFR mutations in Korean men who smoked with adenocarcinoma histology suggests that these patients should not be left behind EGFR mutation test.

PMID: 22237264 [PubMed - as supplied by publisher]

Acinar cell carcinoma of the pancreas: a possible role of s-1 as chemotherapy for acinar cell carcinoma. A case report.

Fetched: January 13th, 2012, 10:00pm MST

Acinar cell carcinoma of the pancreas: a possible role of s-1 as chemotherapy for acinar cell carcinoma. A case report.

JOP. 2012 Jan;13(1):87-90

Authors: Yamamoto T, Ohzato H, Fukunaga M, Imamura H, Furukawa H

PMID: 22233955 [PubMed - in process]

Clinical analysis of acinic cell carcinoma in parotid gland.

Fetched: January 12th, 2012, 10:00pm MST

Clinical analysis of acinic cell carcinoma in parotid gland.

Clin Exp Otorhinolaryngol. 2011 Dec;4(4):188-92

Authors: Cha W, Kim MS, Ahn JC, Cho SW, Sunwoo W, Song CM, Kwon TK, Sung MW, Kim KH

Abstract
OBJECTIVES: Acinic cell carcinoma (AciCC) is a rarely encountered malignancy in parotid gland. Because AciCC is rare and was recently recognized as the entity of malignancy, AciCC has been difficult to study. We aimed to analyze the diagnosis and treatment experience for this malignancy in our hospital.
METHODS: We retrospectively reviewed medical records of the 20 patients with AciCC of parotid gland diagnosed from 1990 to 2009. The preoperative computed tomography scan, preoperative fine needle aspiration cytology (FNAC) and intraoperative frozen section results were compared with the final diagnosis. The survival and recurrence were analyzed with the cancer stages and treatment modalities.
RESULTS: There were 10 males and 10 females, with a mean age of 44.4 years, ranging 8-77 years. The AJCC tumor stage distributions of the patients were 70%, 15%, and 15% for stages I, II, and IV, respectively. The sensitivity of FNAC and intraoperative frozen section was 26.7% and 50.0% respectively. The 10-year survival rate was 90.9% with a mean follow-up of 111 months, ranging 17-251 months. The 10-year disease free survival rate was 74.2% and the mean duration of recurrence from initial surgery was 92.3 months.
CONCLUSION: AciCC of the parotid gland is a rare malignancy that has features of less aggressive behavior, and good prognosis. Intraoperative frozen section examination may be helpful in the diagnosis of AciCC of the parotid gland because of the low sensitivity of preoperative computed tomography scan and FNAC. Surgery with adjuvant postoperative radiotherapy is satisfactory for disease control.

PMID: 22232714 [PubMed - in process]

The utility of a novel antibody in the pathological diagnosis of pancreatic acinar cell carcinoma.

Fetched: January 11th, 2012, 10:00pm MST

The utility of a novel antibody in the pathological diagnosis of pancreatic acinar cell carcinoma.

J Clin Pathol. 2012 Jan 7;

PMID: 22228907 [PubMed - as supplied by publisher]

Reduced α-dystroglycan expression correlates with shortened patient survival in pancreatic cancer.

Fetched: January 11th, 2012, 10:00pm MST

Reduced α-dystroglycan expression correlates with shortened patient survival in pancreatic cancer.

J Surg Res. 2011 Nov;171(1):120-6

Authors: Jiang X, Rieder S, Giese NA, Friess H, Michalski CW, Kleeff J

PMID: 20338590 [PubMed - indexed for MEDLINE]

Histological variants of prostatic carcinoma and their significance.

Fetched: January 5th, 2012, 10:00pm MST

Histological variants of prostatic carcinoma and their significance.

Histopathology. 2012 Jan;60(1):59-74

Authors: Humphrey PA

PMID: 22212078 [PubMed - in process]

Precursors of prostate cancer.

Fetched: January 5th, 2012, 10:00pm MST

Precursors of prostate cancer.

Histopathology. 2012 Jan;60(1):4-27

Authors: Bostwick DG, Cheng L

PMID: 22212075 [PubMed - in process]

Adenocarcinomas With Prominent Lepidic Spread: Retrospective Review Applying New Classification of the American Thoracic Society.

Fetched: December 28th, 2011, 10:00pm MST

Adenocarcinomas With Prominent Lepidic Spread: Retrospective Review Applying New Classification of the American Thoracic Society.

Am J Surg Pathol. 2011 Dec 23;

Authors: Xu L, Tavora F, Battafarano R, Burke A

PMID: 22198010 [PubMed - as supplied by publisher]

Acinar cell carcinoma of the pancreas: a case report and review of the literature.

Fetched: December 25th, 2011, 10:00pm MST

Acinar cell carcinoma of the pancreas: a case report and review of the literature.

Acta Chir Belg. 2011 Sep-Oct;111(5):319-22

Authors: Karagianopoulou G, Noussios G, Katsourakis A, Karavalaki M, Tzegas S, Chatzitheoklitos E

PMID: 22191136 [PubMed - in process]

The lipid kinase PI4KIIIβ and the eEF1A2 oncogene co-operate to disrupt three-dimensional in vitro acinar morphogenesis.

Fetched: December 21st, 2011, 10:00pm MST

The lipid kinase PI4KIIIβ and the eEF1A2 oncogene co-operate to disrupt three-dimensional in vitro acinar morphogenesis.

Exp Cell Res. 2011 Oct 15;317(17):2503-11

Authors: Pinke DE, Lee JM

PMID: 21851817 [PubMed - indexed for MEDLINE]

Does lung adenocarcinoma subtype predict patient survival?: A clinicopathologic study based on the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary lung aden

Fetched: December 21st, 2011, 10:00pm MST

J Thorac Oncol. 2011 Sep;6(9):1496-504

Authors: Russell PA, Wainer Z, Wright GM, Daniels M, Conron M, Williams RA

PMID: 21642859 [PubMed - indexed for MEDLINE]

Sclerosing polycystic adenosis of the submandibular gland.

Fetched: December 20th, 2011, 10:00pm MST

Sclerosing polycystic adenosis of the submandibular gland.

Acta Otorrinolaringol Esp. 2011 Dec 12;

Authors: Beato Martínez A, Moreno Juara A, Candia Fernández A

PMID: 22169590 [PubMed - as supplied by publisher]

From tissue turnover to the cell of origin for pancreatic cancer.

Fetched: December 20th, 2011, 10:00pm MST

From tissue turnover to the cell of origin for pancreatic cancer.

Nat Rev Gastroenterol Hepatol. 2011 Aug;8(8):467-72

Authors: Kong B, Michalski CW, Erkan M, Friess H, Kleeff J

PMID: 21750515 [PubMed - indexed for MEDLINE]

Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs.

Fetched: December 20th, 2011, 10:00pm MST

Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs.

Lung Cancer. 2011 Aug;73(2):176-82

Authors: Chung JH, Rho JK, Xu X, Lee JS, Yoon HI, Lee CT, Choi YJ, Kim HR, Kim CH, Lee JC

PMID: 21168239 [PubMed - indexed for MEDLINE]

Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic kras in the nestin cell lineage.

Fetched: December 9th, 2011, 10:00pm MST

Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic kras in the nestin cell lineage.

PLoS One. 2011;6(11):e27725

Authors: Carrière C, Young AL, Gunn JR, Longnecker DS, Korc M

PMID: 22140463 [PubMed - in process]

Re-Evaluating Historic Cohort of Salivary Acinic Cell Carcinoma with New Diagnostic Tools.

Fetched: December 6th, 2011, 10:00pm MST

Re-Evaluating Historic Cohort of Salivary Acinic Cell Carcinoma with New Diagnostic Tools.

Head Neck Pathol. 2011 Nov 30;

Authors: Lei Y, Chiosea SI

PMID: 22127547 [PubMed - as supplied by publisher]

Glypican-3 as a potential differential diagnosis marker for hepatocellular carcinoma: A tissue microarray-based study.

Fetched: December 6th, 2011, 10:00pm MST

Glypican-3 as a potential differential diagnosis marker for hepatocellular carcinoma: A tissue microarray-based study.

Acta Histochem. 2011 Nov 24;

Authors: Zhang L, Liu H, Sun L, Li N, Ding H, Zheng J

PMID: 22119409 [PubMed - as supplied by publisher]

Review of small cell carcinomas of the prostate.

Fetched: November 25th, 2011, 10:00pm MST

Review of small cell carcinomas of the prostate.

Prostate Cancer. 2011;2011:543272

Authors: Furtado P, Lima MV, Nogueira C, Franco M, Tavora F

PMID: 22110988 [PubMed - in process]

Acinar cell carcinoma with fatty change arising from the pancreas.

Fetched: November 25th, 2011, 10:00pm MST

Acinar cell carcinoma with fatty change arising from the pancreas.

Br J Radiol. 2011 Dec;84(1008):e226-8

Authors: Chung WS, Park MS, Kim DW, Kim KW

PMID: 22101587 [PubMed - in process]

Claudin-18 is an early-stage marker of pancreatic carcinogenesis.

Fetched: November 17th, 2011, 10:00pm MST

Claudin-18 is an early-stage marker of pancreatic carcinogenesis.

J Histochem Cytochem. 2011 Oct;59(10):942-52

Authors: Tanaka M, Shibahara J, Fukushima N, Shinozaki A, Umeda M, Ishikawa S, Kokudo N, Fukayama M

PMID: 21832145 [PubMed - indexed for MEDLINE]

Acinar Cell Carcinoma Responding to Carboplatin/Etoposide Chemotherapy.

Fetched: November 10th, 2011, 10:00pm MST

Acinar Cell Carcinoma Responding to Carboplatin/Etoposide Chemotherapy.

J Gastrointest Cancer. 2011 Nov 8;

Authors: Sorscher SM

PMID: 22058048 [PubMed - as supplied by publisher]

Acinar Cell Carcinoma of the Pancreas: New Genetic and Treatment Insights into a Rare Malignancy.

Fetched: November 4th, 2011, 11:00pm MDT

Acinar Cell Carcinoma of the Pancreas: New Genetic and Treatment Insights into a Rare Malignancy.

Oncologist. 2011 Oct 31;

Authors: Lowery MA, Klimstra DS, Shia J, Yu KH, Allen PJ, Brennan MF, O'Reilly EM

PMID: 22042785 [PubMed - as supplied by publisher]

Radiology Quiz Case 3: Diagnosis - Archives of Otolaryngology

Posted: January 16th, 2012, 12:23pm MST

Radiology Quiz Case 3: Diagnosis
Archives of Otolaryngology
An MRI of the face is crucial to evaluate subtle malignant parotid primary tumors, especially adenoid cystic carcinoma. 6 Perineural tumor spread usually presents with nerve enhancement or thickening on gadolinium-enhanced (fat-suppressed) T1-weighted ...

and more »

The Year in Song - Packet Online

Posted: December 30th, 2011, 2:17pm MST

Packet Online

The Year in Song
Packet Online
A big change in Mr. Tork's life came in 2009, when he was diagnosed with Adenoid cystic carcinoma on the lower part of his tongue and was treated at Memorial Sloan-Kettering Cancer Center. ”I'm feeling much better and am fine now,” Mr. Tork says.

AKF President Named to NIH Council of Councils - Renal Business Today

Posted: December 21st, 2011, 6:57am MST

AKF President Named to NIH Council of Councils
Renal Business Today
... School of Medicine, New York City, nominated by the National Institute on Drug Abuse Jeffrey A. Kaufman, MBA, Adenoid Cystic Carcinoma Research Foundation, Needham, Mass., nominated by the National Institute of Dental and Craniofacial Research.

New NIH Council of Councils members named - National Institutes of Health (press release)

Posted: December 19th, 2011, 6:38am MST

New NIH Council of Councils members named
National Institutes of Health (press release)
said DPCPSI Director, James M. Anderson, MD, Ph.D. Francisco X. Castellanos, MD, New York University School of Medicine, New York City, nominated by the National Institute on Drug Abuse Jeffrey A. Kaufman, MBA, Adenoid Cystic Carcinoma Research ...

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Community still supporting Whitehall resident's family - South Hills Record

Posted: December 15th, 2011, 6:15am MST

Community still supporting Whitehall resident's family
South Hills Record
As she struggled through the pain of the slowly progressing adenoid cystic carcinoma, a cancer of the salivary glands, the 36-year-old Whitehall resident always put others first. Calls, emails or interactions with ...

CHS varsity boys soccer head coach stepping down - Ceres Courier

Posted: November 30th, 2011, 11:39am MST

CHS varsity boys soccer head coach stepping down
Ceres Courier
Phe was diagnosed with adenoid cystic carcinoma, an uncommon type of cancer occurring in the areas of the head and neck. "I tell people I've been to hell and back," said Phe, who had surgery at UC San Francisco Medical Center in 1996 to remove growths ...

Understandng Breast Cancer - Newswire (press release)

Posted: November 27th, 2011, 10:47pm MST

Understandng Breast Cancer
Newswire (press release)
But the adenoid cystic carcinoma of the breast (AdCC) is a form of cancer that is very rare and it constitutes around 0.8 -1 percent of the entire number of cases that are diagnosed each year in United States. Compred to other major types of breast ...

MUSIC PREVIEW: Peter Tork & Shoe Sude Blues - Packet Online

Posted: November 23rd, 2011, 4:41pm MST

Packet Online

MUSIC PREVIEW: Peter Tork & Shoe Sude Blues
Packet Online
A big change in Mr. Tork's life came in 2009, when he was diagnosed with Adenoid cystic carcinoma on the lower part of his tongue and was treated at Memorial Sloan-Kettering Cancer Center. ”I'm feeling much better and am fine now,” Mr. Tork says. ...

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Lisa refuses to bow to cancer - Stonnington Leader

Posted: November 23rd, 2011, 10:07am MST

Stonnington Leader

Lisa refuses to bow to cancer
Stonnington Leader
Ms O'Hara, a model and university student, was diagnosed with adenoid cystic carcinoma in her right salivary gland in April. She has endured countless invasive tests, 30 radiotherapy treatments and an operation that lasted for 15 hours. ...

Ex-lifeguard's saving lives again after cancer battle - East Lothian Courier

Posted: November 17th, 2011, 1:52am MST

Ex-lifeguard's saving lives again after cancer battle
East Lothian Courier
He completed a six-week course of radiotherapy at the Western at the end of September after being diagnosed with adenoid cystic carcinoma (ACC), a rare form of cancer which occurs within glands, mainly in the head and neck. His cancer diagnosis came as ...

Make-Up With A Mission - Oakdale Leader

Posted: November 16th, 2011, 7:07am MST

Make-Up With A Mission
Oakdale Leader
8132 When doctors diagnosed Mary Carey, an attractive saleswoman by trade and an all-round take-charge kind of woman, with adenoid cystic carcinoma, a rare and particularly aggressive form of cancer, her reaction was understandable. ...

It's me versus cancer - Cranbourne Leader

Posted: November 15th, 2011, 10:12am MST

Cranbourne Leader

It's me versus cancer
Cranbourne Leader
Ms O'Hara, a model and university student, was diagnosed with Adenoid Cystic Carcinoma in her right salivary gland in April. She said she was in shock when told, but her reaction surprised her. “My mum was crying and the surgeon had tears in his eyes ...

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I won't let cancer beat me - model - Herald Sun

Posted: November 9th, 2011, 2:28am MST

I won't let cancer beat me - model
Herald Sun
The Melbourne model has already lost half her eyesight and jaw to a rare cancer, Adenoid Cystic Carcinoma. Despite countless operations, tests and radiotherapy the 23 year old's tumours have spread to her cavernous sinus and lungs. ...

Aggressive Nonmelanoma Skin Cancers Often Misdiagnosed - The Oncology Report

Posted: November 8th, 2011, 11:18am MST

Aggressive Nonmelanoma Skin Cancers Often Misdiagnosed
The Oncology Report
Aggressive subtypes of nonmelanoma skin cancer include basosquamous carcinoma, invasive SCC, and morpheaform, infiltrating, keratinizing, and micronodular BCC. Nonaggressive subtypes include follicular, nodular, adenoid cystic, and superficial BCC, ...

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Aggressive Nonmelanoma Skin Cancers Often Misdiagnosed - Skin and Allergy News Digital Network

Posted: November 8th, 2011, 11:09am MST

Aggressive Nonmelanoma Skin Cancers Often Misdiagnosed
Skin and Allergy News Digital Network
Aggressive subtypes of nonmelanoma skin cancer include basosquamous carcinoma, invasive SCC, and morpheaform, infiltrating, keratinizing, and micronodular BCC. Nonaggressive subtypes include follicular, nodular, adenoid cystic, and superficial BCC, ...

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Study Links Gene Mutations With MDS Morphology - Clinical Oncology News

Posted: November 7th, 2011, 1:25pm MST

Clinical Oncology News

Study Links Gene Mutations With MDS Morphology
Clinical Oncology News
... one of 32 with multiple myeloma (3%) and one of 27 with adenoid cystic carcinoma (4%). Finally, the investigators examined 746 cancer cell lines, and identified SF3B1 mutations in eight (1%), including cell lines representing melanoma; lung, ...

Polymorphus low-grade adenocarcinoma of the maxilla: pathological findings and reconstructive considerations.

Fetched: January 27th, 2012, 10:00pm MST

Polymorphus low-grade adenocarcinoma of the maxilla: pathological findings and reconstructive considerations.

Minerva Stomatol. 2012 Jan-Feb;61(1-2):37-43

Authors: Cuesta M, Bucci T, Gonzalez Lopez LM, Duarte Ruiz B, Riba Garcia F

Abstract
Polymorphous low-grade adenocarcinoma (PLGA) is a rare, malignant salivary gland tumor, which is found almost exclusively in minor salivary glands, primarily those in the palate. We report a case of PLGA arising from minor salivary gland of the palate in a 63-year-old female patient. The tumor was resected through the oral cavity performing a bilateral maxillectomy and surgical defect was reconstructed using a free radial forearm flap combined with iliac crest bone graft. The patient was free of disease at 48 months follow-up. The histopathological features of PLGA, the importance of differential diagnosis from pleomorphic adenoma and adenoid cystic carcinoma and the type of reconstruction are discussed in this article.

PMID: 22274309 [PubMed - in process]

Oestrogen receptor β in adenoid cystic carcinoma of salivary glands.

Fetched: January 22nd, 2012, 10:00pm MST

Oestrogen receptor β in adenoid cystic carcinoma of salivary glands.

Histopathology. 2012 Jan 19;

Authors: Marques YM, Giudice FS, Freitas VM, Abreu E Lima MD, Hunter KD, Speight PM, Machado de Sousa SC

Abstract
Marques Y M F S, Giudice F S, Freitas V M, Abreu e Lima M d C C, Hunter K D, Speight P M & Machado de Sousa S C O (2012) Histopathology Oestrogen receptor β in adenoid cystic carcinoma of salivary glands Aims: This study aimed to describe the expression of oestrogen receptor (ER)α, ERβ and aromatase in salivary gland adenoid cystic carcinoma (ACC). Methods and results: ERα, ERβ and aromatase expression was analysed by immunohistochemistry in tissue microarray blocks from 38 cases of ACC and seven normal salivary glands. The intracellular localization and amount of total protein expression were investigated by immunofluorescence and western blotting in an ACC cell line. Western blotting analysis showed overexpression of ERα, ERβ and aromatase in the ACC cell line; however, with immunofluorescence, only ERβ was shown to be expressed in the nucleus. Immunohistochemistry revealed positive nuclear expression of ERβ, positive cytoplasmic expression of aromatase and a lack of ERα expression as compared with normal salivary glands. Conclusions: The nuclear expression of ERβ indicates that oestrogen may be active in ACC and possibly able to mediate E2-targeted gene transcription. This study strongly suggests that ERβ may be involved in tumour progression, playing a role in tumour development, and thus corroborating the indication for ER antagonists in the clinical control of ACC. This study opens a new perspective on the potential use of anti-oestrogens and aromatase inhibitors as therapeutic agents against ACC.

PMID: 22260414 [PubMed - as supplied by publisher]

Primary intracranial adenoid cystic carcinoma.

Fetched: January 22nd, 2012, 10:00pm MST

Primary intracranial adenoid cystic carcinoma.

Clin Neurol Neurosurg. 2012 Jan 16;

Authors: Ma L, Liu JG, Liu XS, You C

PMID: 22257517 [PubMed - as supplied by publisher]

Long-term treatment outcome of minor salivary gland carcinoma of the hard palate.

Fetched: January 20th, 2012, 10:00pm MST

Long-term treatment outcome of minor salivary gland carcinoma of the hard palate.

Oral Oncol. 2012 Jan 14;

Authors: Li Q, Zhang XR, Liu XK, Liu ZM, Liu WW, Li H, Guo ZM

PMID: 22248739 [PubMed - as supplied by publisher]

Salivary Gland Cancers: Biology and Molecular Targets for Therapy.

Fetched: January 20th, 2012, 10:00pm MST

Salivary Gland Cancers: Biology and Molecular Targets for Therapy.

Curr Oncol Rep. 2012 Jan 14;

Authors: Bell D, Hanna EY

Abstract
Salivary gland carcinomas are a heterogeneous group of tumors with different biologic behavior. Given the lack of large randomized studies, there is no standard treatment for advanced and/or metastatic salivary gland tumors, and systemic therapy is empirically based. Tumor-specific recurrent chromosomal translocations and fusion oncogenes in aggressive head and neck malignancies have diagnostic, therapeutic, and prognostic implications. Pathognomonic fusion transcripts have been identified in subsets of mucoepidermoid carcinoma and adenoid cystic carcinoma. These translocations target 1) transcription factors involved in growth factor signaling and cell cycle regulation, 2) transcriptional co-activators, and 3) tyrosine kinase receptors. Prioritizing studies with a translational component to advance the molecular understanding of these cancers and molecular-targeted therapy clinical trials is critical.

PMID: 22246609 [PubMed - as supplied by publisher]

[The effect of MAB225 on radiosensitivity of salivary gland adenoid cystic carcinoma].

Fetched: January 20th, 2012, 10:00pm MST

[The effect of MAB225 on radiosensitivity of salivary gland adenoid cystic carcinoma].

Shanghai Kou Qiang Yi Xue. 2011 Dec;20(6):603-7

Authors: Liu L, Liu XM, Lv Y, Hu HS, Cai YL

Abstract
PURPOSE: To observe the effect of epidermal growth factor receptor's monoclonal antibody(MAB225) on radiosensitivity of salivary gland adenoid cystic carcinoma cell.
METHODS: Bi-fluorescence stain ,MTT test and fluorescence flow cytometry(FCM) were used to observe the apoptosis rate and radiosensitizing effect for MAB225 on ACC-2 cell.SPSS11.0 software package was used for data analysis.
RESULTS: Through bi-fluorescence stain, MTT test and fluorescence flow cytometry(FCM),it was found that MAB225 combined with radiation treatment produced a 3-fold induction of apoptosis rate, whereas exposure to radiation alone induced apoptosis only 1 fold, compared to the control group.
CONCLUSION: MAB225 enhanced radiosensitivity and decreased survival rates of ACC-2 cell in vitro after radiation.

PMID: 22241308 [PubMed - in process]

Spiradenocylindroma: rapid increase in size attributed to hemorrhage.

Fetched: January 20th, 2012, 10:00pm MST

Spiradenocylindroma: rapid increase in size attributed to hemorrhage.

J Dermatol. 2011 Sep;38(9):944-7

Authors: Yazganoglu KD, Baykal C, Buyukbabani N

PMID: 21998839 [PubMed - indexed for MEDLINE]

Cytopathologic analysis of stroma-poor salivary gland epithelial/myoepithelial neoplasms on fine needle aspiration.

Fetched: January 14th, 2012, 10:00pm MST

Cytopathologic analysis of stroma-poor salivary gland epithelial/myoepithelial neoplasms on fine needle aspiration.

Acta Cytol. 2012;56(1):25-33

Authors: Chen L, Ray N, He H, Hoschar A

Abstract
Objective: Fine needle aspiration (FNA) diagnosis of salivary gland neoplasms with epithelial/myoepithelial cells but rare or no stroma is usually difficult. Our aim was to study the cytomorphology of this cohort of FNA cases and evaluate the clinical follow-up. Study Design: The diagnostic terminology for this group of aspirates was 'favor an epithelial/myoepithelial neoplasm of the salivary gland'. The cytologic smears of 32 such cases were retrieved and showed cellular smears with bland-appearing or mildly atypical epithelial and myoepithelial cells without typical chondromyxoid stroma seen in pleomorphic adenoma (PA). Results: Twenty of the 32 cases had histologic follow-up. Ten of these 20 cases were PAs, including 8 cellular PAs. Two cases were basal cell adenomas, 1 case myoepithelioma and 1 case benign adenoma, not otherwise specified. Among the 6 malignant tumors on surgical resections, there were 3 epithelial-myoepithelial carcinomas, 1 myoepithelial carcinoma, 1 basal cell adenocarcinoma and 1 adenoid cystic carcinoma. Conclusions: Although 14 of the 20 (70%) cases were benign neoplasms, a substantial amount of cases (30%) were malignant salivary gland neoplasms. The generic diagnostic terminology of 'epithelial/myoepithelial neoplasm of the salivary gland' and appropriate clinical follow-up are recommended for these cases.

PMID: 22236742 [PubMed - in process]

Clinicopathological features of salivary and non-salivary adenoid cystic carcinomas.

Fetched: January 12th, 2012, 10:00pm MST

Clinicopathological features of salivary and non-salivary adenoid cystic carcinomas.

Int J Oral Maxillofac Surg. 2012 Jan 7;

Authors: Lin YC, Chen KC, Lin CH, Kuo KT, Ko JY, Hong RL

Abstract
Adenoid cystic carcinoma (ACC), commonly from salivary glands, is known for its insidious local growth and usually protracted clinical course. ACC developing from non-salivary glands (i.e., non-salivary ACC) is heterogeneous, and its clinicopathological features remain poorly defined. Patients treated for ACC in a single institution between 1995 and 2007 were included in this study. Immunohistochemical evaluation of Ki-67, E-cadherin, p16, and cyclinD1 was performed. The prognostic significance of clinical and immunophenotypic markers was evaluated. 83 cases of salivary ACC and 24 cases of non-salivary ACC were included. The expression levels of Ki-67 (54.8%), E-cadherin (90.4%), p16 (32.9%), and cyclinD1 (19.2%) between ACCs present at various sites were not different. Sinonasal, lacrimal, and tracheobronchial ACCs had significantly worse outcomes than those of ACC of the major salivary glands. Postoperative radiotherapy reduced the recurrence rate of patients with a negative resection margin (P=0.028). Older age (age >60 years), advanced stage, positive resection margin, high histological grade, and high expression of Ki-67 were significantly correlated with poor prognosis. In conclusion, the site of origin plays a role in the prognosis of ACC, in which positive resection margin and advanced stage are possible factors underlying the differences in outcomes.

PMID: 22230288 [PubMed - as supplied by publisher]

Primary cutaneous adenoid cystic carcinoma of the upper lid: a case report and literature review.

Fetched: January 11th, 2012, 10:00pm MST

Primary cutaneous adenoid cystic carcinoma of the upper lid: a case report and literature review.

Int Ophthalmol. 2012 Jan 7;

Authors: Cavazza S, Laffi GL, Lodi L, Collina G

Abstract
To report on the diagnostic challenge of an adenoid cystic carcinoma arising from the eyelid. A 77-year-old male was referred to our center with a clinical diagnosis of upper eyelid chalazion for a lesion that had appeared 2 years before. A loss of cilia was observed over the cutaneous area of induration, but there was no reddening or ulceration. Incisional biopsy was performed and the specimen was submitted in formalin for histopathological examination. On light microscopy, the lesion was composed of basaloid epithelial and myoepithelial cells that were arranged in strands or nests and associated with cystic spaces that contained a deeply eosinophilic secretory substance and an Alcian blue-positive material, characteristic of adenoid cystic carcinoma. After histological diagnosis, tumor re-excision was performed to ensure adequacy of resection margins, as well as a sentinel lymph node procedure, resulting in complete excision of the malignant tumor. No recurrence was observed during the first 18 months after surgery. Adenoid cystic carcinoma is a rare and aggressive epithelial malignancy, which tends to grow slowly and should be considered in the differential diagnosis of eyelid tumors simulating chalazion.

PMID: 22228272 [PubMed - as supplied by publisher]

Immuno-histochemical evaluation of Cathepsin D in malignant salivary gland carcinomas.

Fetched: January 11th, 2012, 10:00pm MST

Immuno-histochemical evaluation of Cathepsin D in malignant salivary gland carcinomas.

Gulf J Oncolog. 2012 Jan;1(11):38-44

Authors: Sivaranjini Y, Angadi PV, Kumar G

Abstract
Objective: Cathepsin D is a lysosomal acid protease secreted in increased levels in several malignancies. However, its role in salivary gland tumors has not been studied extensively. The present study aims to assess the expression of Cathepsin D in malignant salivary gland tumors and to compare its expression in these tumors. Study design: A total of 30 cases of malignant salivary gland carcinomas which included 16 cases of adenoid cystic carcinoma (ACC), 9 cases of mucoepidermoid carcinoma (MEC), and 5 cases of polymorphous low grade adenocarcinoma (PLGA) were evaluated immunohistochemically using anti-Cathepsin D antibody. Result: All the cases showed positivity (100%) for Cathepsin D with intense expression noted in ACC and MEC as compared to PLGA. Comparison of these tumors revealed statistical significant difference in expression between ACC and PLGA. Conclusion: Intense expression of Cathepsin D in high grade carcinomas may be a marker for invasive potential and aggressive behavior. Key words: Cathepsin D, Adenoid cystic carcinoma, Mucoepidermoid carcinoma, Polymorphous low grade adenocarcinoma.

PMID: 22227544 [PubMed - in process]

Adenoid cystic carcinoma of the head and neck.

Fetched: January 11th, 2012, 10:00pm MST

Adenoid cystic carcinoma of the head and neck.

Am J Otolaryngol. 2012 Jan 4;

Authors: Balamucki CJ, Amdur RJ, Werning JW, Vaysberg M, Morris CG, Kirwan JM, Mendenhall WM

Abstract
PURPOSE: To report our experience using radiotherapy alone or combined with surgery to treat adenoid cystic carcinoma of the head and neck. MATERIALS AND METHODS: Radiotherapy alone or combined with surgery was used to treat 120 previously untreated patients with adenoid cystic carcinoma (ACC) of the head and neck from August 1966 to March 2008. Patients were treated with curative intent. American Joint Committee on Cancer stage distribution was,T0 (n = 1), T1 (n = 26), T2 (n = 25), T3 (n = 14), T4 (n = 54), N0 (n = 113), N1 (n = 2), N2a (n = 1), N2b (n = 2), and N2c (n = 2). Treatment included surgery with postoperative radiotherapy (n = 71), radiotherapy alone (n = 46), and preoperative radiotherapy and surgery (n = 3). Incidental and clinical perineural invasion was found in 41 (34%) and 35 (29%) patients, respectively. Median follow-up was 8.6 and 11.6 years overall and among living patients, respectively. RESULTS: The10-year overall, cause-specific, and distant metastasis-free survival rates, respectively, were as follows: radiotherapy alone, 37%, 46%, and 76%; surgery and radiotherapy, 57%, 71%, and 62%; and overall, 50%. The10-year local control rates were as follows: radiotherapy alone, 36%; surgery and radiotherapy, 84%; and overall, 65%. The 10-year neck control rates were as follows: elective nodal irradiation (ENI), 98%; no ENI, 89%; and overall, 95%. CONCLUSIONS: Surgery and adjuvant radiotherapy offer the best chance for cure for patients with resectable adenoid cystic carcinomas of the head and neck. Some patients with advanced, incompletely resectable disease can be cured with radiotherapy alone. ENI should be considered for primary sites located in lymphatic-rich regions.

PMID: 22226227 [PubMed - as supplied by publisher]

Cytogenetic findings in benign and malignant oral tumors - the role of autologous human plasma.

Fetched: January 11th, 2012, 10:00pm MST

Cytogenetic findings in benign and malignant oral tumors - the role of autologous human plasma.

Br J Oral Maxillofac Surg. 2012 Jan 5;

Authors: Manor E, Tetro S, Brennan PA, Bodner L

Abstract
The present study examined the possible use of autologous human plasma (AHP) to improve the in vitro culture for cytogenetics of benign and malignant oral tumor cells. The effect of AHP on the growth of a variety of benign and malignant head and neck tumor cells was studied by inverted microscope and cytogenetic analysis. Minced tumor biopsies of cases of hemangioma (HM), lipoma (LP), central giant cell granuloma (GC), pleomorphic adenoma (PA), schwannoma (SW), oral squamous cell carcinoma (SCC), Ewing sarcoma (ES), Merkel cell carcinoma (MCC) and adenoid cystic carcinoma (ACC), were cultured in medium supplemented with either AHP, allogeneic pooled human plasma (PHP), or fetal calf serum (FCS). More fibroblasts were seen in the FCS supplemented cultures, while in HP or PHP culture medium, more epithelial-like tumor cells were noted. The karyotypes of HM, LP, GC and PA were normal in all 3 different mediums. Cytogenetic analysis of SW and SCC revealed random numerical changes in all cultures. However, in AHP cultures a clone bearing translocation was found in SW t(2;13). In the SCC cultures one tumor had t(12;14) and the other t(3;21) translocations. Complex karyotype was found in all kinds of cultures in ES, MCC and ACC. AHP by itself does not cause chromosomal aberrations but may improve the ability to find chromosomal aberrations in some tumors over medium containing FCS. The spectrum of oral tumors where AHP can improve the cytogenetic analyses should be further studied on a greater number of tumors.

PMID: 22226016 [PubMed - as supplied by publisher]

A Case of Adenoid Cystic Carcinoma Presenting as Garcin's Syndrome without Mass Formation.

Fetched: January 6th, 2012, 10:00pm MST

A Case of Adenoid Cystic Carcinoma Presenting as Garcin's Syndrome without Mass Formation.

Intern Med. 2012;51(1):87-91

Authors: Inose Y, Kobayashi M, Hiroi A, Toi S, Maruyama K, Shimizu Y, Shibata N, Yoshihara T, Uchiyama S

Abstract
Adenoid cystic carcinoma (ACC) is a malignant neoplasm that commonly arises in the major or minor salivary gland and usually forms mass lesions. Here, we report a case of ACC involving a 56-year-old man, who displayed right multiple cranial nerve palsies with ipsilateral severe facial pain but not any mass formation. Right submaxillary gland biopsy after repeated challenges at last revealed the primary focus of ACC with perineural invasion and without lymph node metastasis. The neurological manifestations were considered to be attributed to the perineural spread of ACC. It is extremely rare for ACC to show Garcin's syndrome without mass formation.

PMID: 22214630 [PubMed - in process]

Treatment outcomes and prognostic features in adenoid cystic carcinoma originated from the head and neck.

Fetched: January 4th, 2012, 10:00pm MST

Treatment outcomes and prognostic features in adenoid cystic carcinoma originated from the head and neck.

Oral Oncol. 2011 Dec 29;

Authors: Shen C, Xu T, Huang C, Hu C, He S

Abstract
Surgery is the main treatment modality for adenoid cystic carcinoma (ACC) originated from the head and neck. However, the extensive local infiltrative and perineural spread related to this malignancy often cause difficulty to achieve high tumor control. The aim of this study is to evaluate the efficacy of postoperative radiotherapy (RT) in ACC, and to identify prognostic variables associated with treatment outcomes. A retrospective review of 101 patients diagnosed with ACC in the head and neck region was performed. T stage distribution was T1, 25; T2, 35; T3, 18; and T4, 23 patients. All patients were grouped into two arms: surgery alone or combined with postoperative radiotherapy. The 5-year local-regional control (LRC), overall survival (OS) and disease-free survival (DFS) rates for all the patients were 70.5%, 91.7% and 63.2%, respectively. On univariant analysis, postoperative radiotherapy did improve the 5-year LRC and DFS compared to surgery alone (81.0% vs. 53.4%, p=0.0003 and 71.3% vs. 50.0%, p=0.0052, respectively). And patients with T1-T2 lesions achieved better treatment outcomes, whereas stage T3-T4 was associated with high local failure and poor disease-free survival. Furthermore, multivariate analysis revealed that the addition of radiotherapy and early lesions were both favorite predictors for local control and survival rates. The prognosis for ACC of the head and neck was excellent. Surgery combined with postoperative radiotherapy significantly reduced the local failure, and further improved disease-free survival. Nevertheless, the relatively high distant metastasis was an obstacle of curing the ACC patients.

PMID: 22209446 [PubMed - as supplied by publisher]

EMMPRIN contributes to the in vitro invasion of human salivary adenoid cystic carcinoma cells.

Fetched: December 29th, 2011, 10:00pm MST

EMMPRIN contributes to the in vitro invasion of human salivary adenoid cystic carcinoma cells.

Oncol Rep. 2011 Dec 22;

Authors: Yang X, Zhang P, Ma Q, Kong L, Li Y, Liu B, Lei D

Abstract
Extracellular matrix metalloproteinase inducer (EMMPRIN) is a transmembrane glycoprotein that is involved in tumor invasion by stimulating matrix metalloproteinase (MMP) expression. Our previous immunohistochemical study found that the expression of EMMPRIN in salivary adenoid cystic carcinoma (SACC) was positively correlated with tumor perineural and perivascular invasion. The present study was designed to further investigate the role of EMMPRIN in the invasion of SACC. Western blot results showed that EMMPRIN was upregulated in the highly metastatic SACC cell line SACC-LM, compared to SACC-83, a SACC cell line with low metastatic ability. Blocking of EMMPRIN by its antibody significantly decreased the adhesion, secretion of MMP-2 and MMP-9, and invasion activity of SACC-LM cells in vitro (P<0.01). Co-cultures of SACC-LM cells with fibroblasts significantly produced elevated levels of MMP-2 and MMP-9, and promoted the in vitro invasion activity of SACC-LM cells, compared with cultures of SACC-LM cells alone (P<0.01). These results indicate that EMMPRIN may play an important role in the invasion of SACC by stimulating the expression of MMP-2 and MMP-9 in tumor and stromal cells.

PMID: 22200897 [PubMed - as supplied by publisher]

Nasopharyngeal adenoid cystic carcinoma: magnetic resonance imaging features in ten cases.

Fetched: December 29th, 2011, 10:00pm MST

Nasopharyngeal adenoid cystic carcinoma: magnetic resonance imaging features in ten cases.

Chin J Cancer. 2011 Dec 23;

Authors: Liu XW, Xie CM, Li H, Zhang R, Geng ZJ, Mo YX, Zhao J, Cai MY, Lv YC, Wu PH

Abstract
Nasopharyngeal adenoid cystic carcinoma (NACC) is a rare malignancy with high local invasiveness. To date, there is no clear consensus on the imaging characteristics of NACC. To address this, we retrospectively reviewed 10 cases of NACC and summarized the magnetic resonance imaging (MRI) features. Magnetic resonance images of 10 patients with histologically validated NACC were reviewed by two experienced radiologists. The locations, shapes, margins, signal intensity, lesion texture, contrast enhancement patterns, local invasion, and cervical lymphadenopathy of all tumors were evaluated. Clinical and pathological records were also reviewed. None of the patients tested positive for antibodies against Epstein-Barr virus (EBV). The imaging patterns of primary tumors were classified into two types as determined by location, shape, and margins. Of all patients, 7 had tumors with a type 1 imaging pattern and 3 had tumors with a type 2 imaging pattern. The 4 tubular NACCs were all homogeneous tumors, whereas 3 (60%) of 5 cribriform NACCs and the sole solid NACC were heterogeneous tumors with separations or central necrosis within the lesions on MR images. A total of 5 patients had perineural infiltration and intracranial involvement, and only 2 patients had cervical lymphadenopathy. Based on these results, we conclude that NACC is a local, aggressive neoplasm that is often associated with negative laboratory test results for EBV infection and a low incidence of cervical lymphadenopathy. Furthermore, MRI features of NACC vary in different locations and histiological subtypes.

PMID: 22200180 [PubMed - as supplied by publisher]

Permalink for 'EMMPRIN silencing inhibits proliferation and perineural invasion of human salivary adenoid cystic carcinoma cells in vitro and in vivo.'

EMMPRIN silencing inhibits proliferation and perineural invasion of human salivary adenoid cystic carcinoma cells in vitro and in vivo.

Fetched: December 28th, 2011, 10:00pm MST

EMMPRIN silencing inhibits proliferation and perineural invasion of human salivary adenoid cystic carcinoma cells in vitro and in vivo.

Cancer Biol Ther. 2012 Jan 15;13(2)

Authors: Yang X, Zhang P, Ma Q, Kong L, Li Y, Liu B, Lei D

Abstract
Salivary adenoid cystic carcinoma (SACC) is a frequent subtype of salivary gland malignancy, and it has an important biological behavior for perineural invasion (PNI). Extracellular matrix metalloproteinase inducer (EMMPRIN) is a transmembrane glycoprotein that is involved in the invasive property of many malignancies by stimulating matrix metalloproteinase (MMP) expression. The present study was designed to investigate the role and possible mechanism of EMMPRIN in the PNI of SACC using RNA interference (RNAi) technology. We found that silencing of EMMPRIN expression in the human SACC cell line (SACC-83) suppressed the cell proliferation, adhesion, MMP-2 and MMP-9 secretion, and PNI activity in vitro. EMMPRIN silencing also inhibited the tumor growth and Ki-67 labeled proliferation index in vivo. Using tumor PNI models in nude mice, EMMPRIN silencing inhibited the infiltration, swelling and functional loss of the affected sciatic nerves, as well as the expression of MMP-2 and MMP-9. These results demonstrate that EMMPRIN participates in the PNI of SACC cells by mediating the expression of MMP-2 and MMP-9. Our findings suggest that EMMPRIN is a potential target for anti-PNI treatment in SACC.

PMID: 22198615 [PubMed - as supplied by publisher]

Histopathological study of salivary gland tumours in Ile-Ife, Nigeria.

Fetched: December 25th, 2011, 10:00pm MST

Histopathological study of salivary gland tumours in Ile-Ife, Nigeria.

Niger Postgrad Med J. 2011 Dec;18(4):257-61

Authors: Adebiyi KE, Ndukwe KZ, Ugboko VI, Omoniyi-Esan GO, Oluwafemi OO

Abstract
AIMS AND OBJECTIVES: The objective of this study is to document the prevalence and clinicopathologic features/pattern of salivary gland tumours in Ile-Ife, southwestern Nigeria.
PATIENTS AND METHODS: Fifty eight (58) cases of salivary gland tumours histologically diagnosed between January 1989 and December 2007 were identified from the biopsy records of the Departments of Morbid Anatomy and Forensic Medicine and Oral/Maxillofacial Pathology of the Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria. The records of the patients were extracted and data on incidence, age, gender and site of the various tumours were analysed using descriptive statistics.
RESULTS: Pleomorphic adenoma was the most common salivary gland tumour reported accounting for twenty-five (43.1%), followed by Mucoepidermoid carcinoma (eight, 13.8%). Adenoid cystic carcinoma and myoepithelioma each accounted for six cases (10.3%). Non-Hodgkin's lymphoma of the salivary gland occurred in two patients. Twenty-six (44.8%) cases occurred in males while thirty-two (55.2%) occurred in females giving a male-to-female ratio of 1:1.2. The parotid region was the most common site accounting for twenty-eight (49.1%) cases, followed by the submandibular region 16 (28.1%) and palate 10(17.5%).
CONCLUSIONS: Pleomorphic adenoma is the most common salivary gland tumour. Contrary to other African studies, our series reveals mucoepidermoid carcinoma as the commonest malignant salivary gland tumour.

PMID: 22193994 [PubMed - in process]

Fertility Regulation among Women of Reproductive Age in Ibadan, South-West Nigeria: Contraception, Abortion or Both.

Fetched: December 25th, 2011, 10:00pm MST

Fertility Regulation among Women of Reproductive Age in Ibadan, South-West Nigeria: Contraception, Abortion or Both.

Niger Postgrad Med J. 2011 Dec;18(4):251-6

Authors: Owonikoko KM, Okunola MA, Adeleke AO, Akinboade AF

PMID: 22193993 [PubMed - in process]

What is the best management strategy for adenoid cystic carcinoma of the trachea?

Fetched: December 24th, 2011, 10:00pm MST

What is the best management strategy for adenoid cystic carcinoma of the trachea?

Ann Thorac Cardiovasc Surg. 2011;17(6):535-8

Authors: Suzuki T

PMID: 22190413 [PubMed - in process]

8. Benign and malignant breast lesions mimicking each other: imaging-histopathologic correlation.

Fetched: December 23rd, 2011, 10:00pm MST

8. Benign and malignant breast lesions mimicking each other: imaging-histopathologic correlation.

Cancer Imaging. 2011;11:S180

Authors: Thein KY, Trishna SR, Reynolds V

Abstract
Aims: To determine the incidence and features of breast lesions graded as BIRADS 3 that are proved to be malignant and BIRADS 4 lesions to be benign histologically, with demonstration of their mimicking imaging features. Methods: This was a retrograde study of 101 breast lesions that were histopathologically proven at Khoo Teck Puat Hospital, Singapore from June 2010 to April 2011. The cases were double-read and graded by two radiologists accredited by the Health Promotion Board, Singapore. The concordance of the mammographic and sonographic features with the histopathologic diagnosis was discussed by the multidisciplinary breast tumour board. Results: Of a total 101 cases analyzed, 22 (21.8%) and 53 (52.5%) lesions were reported as BIRADS 3 and BIRADS 4, respectively. Twenty-six (25.7%) cases graded BIRADS 5 were clearly malignant so were not included in the study. One (4.5%) of 22 BIRADS 3 cases was proven to be malignant and 30 (56.6%) of 53 BIRADS 4 lesions were benign. The spectrum of histopathologically benign BIRADS 4 lesions was: 8 fibroadenomas, 6 inflammatory changes, 5 stromal fibrosis, 3 fibroepithelial changes, 3 fibrocystic diseases, 2 ductal papillomas, 1 benign phylloides, 1 pseudoangiomatous stromal hyperplasia and 1 columnar adenosis. The one BIRADS 3 lesion that was malignant histopathologically was a well-defined adenoid cystic carcinoma. Conclusion: There is overlap in the mammographic and sonographic features of benign and malignant breast lesions, especially those graded BIRADS 4, which may cause diagnostic confusion. Lesions graded BIRADS 3 are likely to remain benign and short-term follow-up rather than immediate biopsy is advised.

PMID: 22186419 [PubMed - in process]

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