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Appendix Cancer (33 unread)

PubMed - Appendix Cancer

Metastasis to the appendix from gastric cancer detected incidentally on colonoscopy.

Fetched: April 24th, 2008, 9:00pm EDT

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Metastasis to the appendix from gastric cancer detected incidentally on colonoscopy.

Endoscopy. 2007 Feb;39 Suppl 1:E17

Authors: Fu K, Horimatsu T, Sano Y, Katagiri A, Kaji Y, Fujimori T

PMID: 17285508 [PubMed - indexed for MEDLINE]
An evidence-based approach: Sugarbaker protocol and pseudomyxoma peritonei of appendiceal origin.

Fetched: April 22nd, 2008, 9:00pm EDT

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An evidence-based approach: Sugarbaker protocol and pseudomyxoma peritonei of appendiceal origin.

ANZ J Surg. 2008 May;78(5):327-8

Authors: Lo CH, Bohmer RD, Blomfield PI

PMID: 18380718 [PubMed - indexed for MEDLINE]
An unexpected abdominal 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) in a patient with limited stage small cell lung cancer.

Fetched: April 17th, 2008, 9:00pm EDT

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An unexpected abdominal 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) in a patient with limited stage small cell lung cancer.

J Thorac Oncol. 2008 Feb;3(2):174-6

Authors: Decoster L, Stroobants S, Verbeken E, Nackaerts K, Vansteenkiste J

We report the case of an unexpected 18F-fluorodeoxyglucose-avid lesion in the right lower abdomen in a patient with otherwise "very limited" (T1N0) small cell lung cancer (SCLC). Additional imaging and endoscopic studies showed no abnormality. The patient was treated for presumed very limited disease SCLC, with resection, adjuvant chemotherapy, and prophylactic brain irradiation. Follow-up fusion positron emission tomography-computed tomography revealed an unusual SCLC complication.

PMID: 18303440 [PubMed - indexed for MEDLINE]
[A study on nine cases of mucocele of the appendix]

Fetched: April 9th, 2008, 9:00pm EDT

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[A study on nine cases of mucocele of the appendix]

Nippon Shokakibyo Gakkai Zasshi. 2008 Feb;105(2):214-20

Authors: Waku T

A clinicopathological study was made on 9 cases of mucocele (8 cases of adenoma and 1 case of adenocarcinoma) of the appendix treated at the hospital in the recent 12 years. With abdominal CT, correct preoperative diagnosis was successfully made in 7 out of 9 cases of mucocele of the appendix. Two cases of mucocele of the appendix were diagnosed as peritoneal pseudomyxoma before surgery. The most common operative procedure was ileocecal resection in 4 cases including 2 cases undergone irrigation of the abdominal cavity, and partial cecectomy in 5 cases including 2 cases undergone irrigation in the abdominal cavity. For a patient with adenocarcinoma, we repeated intraperitoneal chemotherapy with cisplatin after surgery. Eight patients with adenoma are doing well, but one patient with adenocarcinoma died 48 months after surgery. Therapeutic approaches based on homogeneous pathologic entities can now be considered rationally.

PMID: 18250592 [PubMed - indexed for MEDLINE]
Villous adenoma after appendiceal uterine transplantation.

Fetched: April 2nd, 2008, 9:00pm EDT

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Villous adenoma after appendiceal uterine transplantation.

Int J Gynaecol Obstet. 2008 Jan;100(1):83-4

Authors: Edden Y, Shussman N, Amir G, Pruss D, Rojansky N, Pikarsky AJ

PMID: 17888436 [PubMed - indexed for MEDLINE]
Application of light microscopical and ultrastructural immunohistochemistry in the study of goblet cell carcinoid in the appendix.

Fetched: April 1st, 2008, 9:01pm EDT

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Application of light microscopical and ultrastructural immunohistochemistry in the study of goblet cell carcinoid in the appendix.

World J Surg Oncol. 2008;6:15

Authors: Gulubova MV, Yovchev Y, Vlaykova T, Hadjipetkov P, Prangova DK, Popharitov A

BACKGROUND: Goblet cell carcinoids appear less frequently in the appendix than do other carcinoids. In the presented work a case with a goblet cell carcinoid of the appendix is described. METHODS: Routine histological and histochemical methods were employed, with a combination of histochemistry and immunohistochemistry on one section and light and electron microscopical immunohistochemisty on paraffin-embedded material, were applied to identify the type of the carcinoid and to reveal the fine structure of cell types in the tumour nests of the appendix. RESULTS: During the biopsy of a patient who had undergone appendectomy, an infiltration with clusters of goblet cells in the submucosa of the appendix was found. After a second operation of right-sided hemicolectomy, similar clusters of goblet cells were detected in the muscle layers of the caecum. After 18 months the patient died from cirrhosis and had not developed metastases or any recurrence. Immunohistochemically the serotonin-, somatostatin-, chromogranin A- and synaptophysin-positive endocrine cells were basally attached to mucin-secreting cells. The combined staining revealed simultaneously present endocrine cells (chromogranin-A-positive) and mucin-secreting cells (PAS- or alcian blue-positive). The ultrastructural immunohistochemistry showed that chromogranin A-positive cells had discoid and pleomorphic granules and were located in tumour nests or as single cells in the appendiceal wall. CONCLUSION: The combined histochemical and immunohistochemical procedure and the ultrastructural immunohistochemistry on archival material could contribute in clarifying the diagnosis of goblet cell carcinoid.

PMID: 18252007 [PubMed - indexed for MEDLINE]
Managing an acute pain crisis in a patient with advanced cancer: "this is as much of a crisis as a code".

Fetched: March 29th, 2008, 9:00pm EDT

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Managing an acute pain crisis in a patient with advanced cancer: "this is as much of a crisis as a code".

JAMA. 2008 Mar 26;299(12):1457-67

Authors: Moryl N, Coyle N, Foley KM

The assessment and management of an acute pain crisis in the setting of advanced illness is challenging. Using the case of Mr X, a 33-year-old man with advanced metastatic mucinous adenocarcinoma of the appendix and "15 out of 10" pain, we explore the issues of acute pain and its management. We define a pain crisis as an event in which the patient reports pain that is severe, uncontrolled, and causing distress for the patient, family members, or both. Our management strategy focuses on making a pain diagnosis, differentiating reversible from intractable causes of pain, and making decisions about further workup; selecting the opioid and monitoring and treating opioid adverse effects; titrating and rotating opioid and coanalgesics; consulting experts to treat a pain crisis as quickly as possible to prevent unnecessary suffering; and co-opting the available institutional resources. The timely intervention of a palliative care team and its expertise can provide the staff, patients, and their families the benefit of an interdisciplinary approach and help the patients address goals of care; understand the benefits and risks of treatment decisions; and meet the psychological, social, and existential needs of the patient and the family commonly seen in this setting.

PMID: 18364488 [PubMed - indexed for MEDLINE]
Interstitial pneumonitis: an exceptional toxicity of hyperthermic intraperitoneal mitomycin C.

Fetched: March 28th, 2008, 9:00pm EDT

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Interstitial pneumonitis: an exceptional toxicity of hyperthermic intraperitoneal mitomycin C.

Eur J Surg Oncol. 2008 Apr;34(4):482-4

Authors: González-Moreno S, Lambert LA, Mansfield PF

PMID: 17434283 [PubMed - indexed for MEDLINE]
Mucinous cystadenoma of appendix.

Fetched: March 26th, 2008, 9:00pm EDT

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Mucinous cystadenoma of appendix.

Indian J Pathol Microbiol. 2007 Oct;50(4):839-40

Authors: Kinra P

PMID: 18306577 [PubMed - indexed for MEDLINE]
Appendectomy or right hemicolectomy in the treatment of appendiceal carcinoid tumors?

Fetched: March 21st, 2008, 9:00pm EDT

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Appendectomy or right hemicolectomy in the treatment of appendiceal carcinoid tumors?

Tumori. 2007 Nov-Dec;93(6):587-90

Authors: Fornaro R, Frascio M, Sticchi C, De Salvo L, Stabilini C, Mandolfino F, Ricci B, Gianetta E

AIMS AND BACKGROUND: Carcinoids of the appendix continue to be of interest, despite their low incidence. There is still considerable controversy surrounding these tumors, especially with regard to the role of right hemicolectomy in the surgical management. The aim of this work was to explicate the current therapeutic knowledge and to review the criteria for the indications of appendectomy or hemicolectomy. METHODS: The records of patients who underwent appendectomies from 1990 to 2000 were analyzed. Seven patients were included in the study. The clinical data were reviewed for demographic details, tumor size, localization in the appendix, histological patterns and surgical procedures. All patients underwent appendectomy including removal of the mesenteriolum, and in one of them a right hemicolectomy was performed 3 weeks later. The mean follow-up was 7 years (range, 4-14). Follow-up data included symptoms, urinary 5-hydroxyindoleacetic acid, ultrasound examination, computerized tomography, and octreotide scanning. RESULTS: Seven patients (0.9% of all appendectomies) were reported to have carcinoid tumors of the appendix. They were 3 men and 4 women with a mean age of 29 years. All patients were admitted for appendicitis. None suffered from the carcinoid syndrome. The site of the tumor was the apex of the appendix in 4 cases, the body in 2 cases and the base in 1 case. Mean tumor diameter was 8 mm (range, 5-29 mm); in 6 patients it was <2 cm. Treatment was appendectomy in all cases; additional right hemicolectomy was necessary in one case because of a tumor of more than 2 cm with invasion of the mesoappendix and lymph nodes. The 7-year survival rate is 100%. Six patients are without disease, while 1 patient (the one who underwent a right hemicolectomy) developed metastases in the liver 6 years after the operation. This patient, who was treated with a liver resection, is still alive. CONCLUSIONS: According to current guidelines, an appendectomy may be performed for small carcinoid tumors (<1 cm). Reasons for more extensive surgery than appendectomy are tumor size >2 cm, lymphatic invasion, lymph node involvement, spread to the mesoappendix, tumor-positive resection margins, and cellular pleomorphism with a high mitotic index. The criteria that direct us towards major (hemicolectomy) or minor surgery (appendectomy) are controversial. Tumor size is still considered the most important prognostic factor, with a presumed increase in the risk of metastasis for tumors greater than 2.0 cm. The accepted treatment of such tumors is a right hemicolectomy. However, there is no evidence demonstrating a survival benefit for right hemicolectomy over simple appendectomy in patients with carcinoids greater than 2.0 cm in diameter.

PMID: 18338494 [PubMed - indexed for MEDLINE]
Periappendiceal dermoid: a rare cause of right lower quadrant pain.

Fetched: March 18th, 2008, 9:00pm EDT

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Periappendiceal dermoid: a rare cause of right lower quadrant pain.

Am Surg. 2008 Jan;74(1):56-8

Authors: Ghersi MM, Carrillo SA, Danielpour P, Willis I

Dermoids are mature teratomas lined with a stratified squamous epithelium. They are known to present anywhere in the body, mostly with minimal or no associated symptoms. The authors present the case of a 44-year-old man who presented with an acute abdomen suggestive of appendiceal disease. On surgical exploration, the patient was found to have an inflamed cystic lesion in the mesoappendix that was resected and diagnosed as a dermoid cyst on pathological examination. This is the seventh case in the literature of a periappendiceal dermoid, but the first that presents in such a manner. This report is presented because of its important clinical applications for the general surgeon.

PMID: 18274430 [PubMed - indexed for MEDLINE]
Pseudomyxoma peritonei: clinical pathological and biological prognostic factors in patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC).

Fetched: March 14th, 2008, 9:00pm EDT

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Pseudomyxoma peritonei: clinical pathological and biological prognostic factors in patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC).

Ann Surg Oncol. 2008 Feb;15(2):526-34

Authors: Baratti D, Kusamura S, Nonaka D, Langer M, Andreola S, Favaro M, Gavazzi C, Laterza B, Deraco M

BACKGROUND: Surgical cytoreduction combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has been recently advocated as the standard of care for pseudomyxoma peritonei (PMP). We reviewed our 10-year monoinstitutional case series to identify selection factors predicting postoperative outcome. METHODS: One hundred and four patients with PMP were operated on with the aim of performing adequate cytoreduction (residual tumor nodules < or =2.5 mm) and closed-abdomen HIPEC with mytomicin-C and cisplatin. Previously, 26 patients had systemic chemotherapy. PMP was histologically classified into disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA), and intermediate/discordant group (ID). Immunohistochemical stains were performed for cytokeratin (CK)-7, CK-20, CDX-2, MUC-2, MUC-5AC, CD-44s. The significance of 22 potential clinical, pathological, and biological prognostic variables was assessed by multivariate analysis. RESULTS: Adequate cytoreduction was performed in 89 patients, suboptimal cytoreduction in six, palliative surgery in nine. Operative mortality was 1%. Seventy-eight patients were diagnosed with DPAM, 26 with PMCA, and none with ID. Median follow-up was 37 months (range, 1-110) for the overall series. Five-year overall survival (OS) and progression-free survival (PFS) were 78.3% and 31.1%, respectively. At multivariate analysis, adequate cytoreduction, no previous systemic chemotherapy, and DPAM correlated to better OS and PFS, elevated serum CA19.9 correlated only to better PFS. In most cases, CK20, CDX-2, and MUC-2 were diffusely positive, while CK-7, MUC-5AC, and CD44s were variably expressed. CK20 expression correlated to prognosis at univariate analysis. CONCLUSIONS: Favorable outcome after comprehensive treatment can be expected in patients with DPAM, not treated with preoperative systemic chemotherapy and amenable to adequate cytoreduction. MUC-2, CK-20, and CD44s expression may be related to PMP unique biologic behavior.

PMID: 18043976 [PubMed - indexed for MEDLINE]
Small cell carcinoma of the appendix.

Fetched: March 7th, 2008, 9:00pm EST

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Small cell carcinoma of the appendix.

World J Surg Oncol. 2008;6:4

Authors: O'Kane AM, O'Donnell ME, Shah R, Carey DP, Lee J

BACKGROUND: An extrapulmonary small cell carcinoma is a rare condition. It has similar histological features to pulmonary small cell carcinoma and is equally aggressive. CASE PRESENTATION: We present the case of a 60-year-old woman who presented with right upper quadrant pain. Computerised tomography revealed an appendiceal lesion and multiple liver metastases. Exploratory laparotomy and right hemicolectomy was performed with histopathological analysis confirming a primary small cell carcinoma of her appendix. CONCLUSION: This is the first reported case of a pure extrapulmonary carcinoma arising from the appendix.

PMID: 18197972 [PubMed - indexed for MEDLINE]
VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon.

Fetched: March 4th, 2008, 9:00pm EST

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VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon.

Ann Surg Oncol. 2008 Mar;15(3):738-44

Authors: Logan-Collins JM, Lowy AM, Robinson-Smith TM, Kumar S, Sussman JJ, James LE, Ahmad SA

BACKGROUND: High levels of vascular endothelial growth factor (VEGF) in ovarian cancer metastases are associated with a worse prognosis in patients treated with chemotherapy. VEGF-directed therapy improves survival for those with metastatic colorectal cancer. Patients with mucinous adenocarcinomas metastatic to the peritoneal surfaces can be treated with cytoreductive surgery, and both tumor grade and cytoreduction status are prognostic. We hypothesized that angiogenic indices may be prognostic in patients undergoing cytoreductive surgery for mucinous adenocarcinoma of the appendix and colon. METHODS: Cytoreductive cases from a 5-year period from the University of Cincinnati peritoneal malignancy database were reviewed. CD 34 counts (blood vessels) and VEGF expression was evaluated by means of immunohistochemistry on specimens from patients undergoing cytoreductive surgery and intraperitoneal hyperthermic perfusion (IPHP) for mucinous adenocarcinoma. RESULTS: A total of 26 males and 9 females, with a mean age of 50 years, underwent cytoreductive surgery and IPHP for mucinous adenocarcinoma of appendiceal (n = 32) or colonic (n = 3) origin. With a mean follow-up of 18 months (range 1-63 months), 23 had disease recurrence and 12 were alive without recurrence. The mean survival was 19 months (range 1-63 months). CD34 counts did not correlate with recurrence or survival; however, average VEGF counts correlated with survival (P = 0.017), and, for patients with recurrence, this correlation was stronger (P = 0.002). CONCLUSIONS: These results suggest that markers of tumor angiogenesis may predict survival in patients with peritoneal surface metastases from mucinous adenocarcinoma. These findings provoke the hypothesis that antiangiogenic therapies may be effective in patients with this devastating disease.

PMID: 18043973 [PubMed - indexed for MEDLINE]
Pseudomyxoma peritonei secondary to epithelial appendicular neoplasms. Experience in a non-specialised centre.

Fetched: March 1st, 2008, 9:00pm EST

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Pseudomyxoma peritonei secondary to epithelial appendicular neoplasms. Experience in a non-specialised centre.

Clin Transl Oncol. 2007 Nov;9(11):737-41

Authors: Ruiz-Tovar J, Morales Castiñeiras V, García Teruel D, Sanjuanbenito Dehesa A, Lobo Martínez E, Martínez Molina E

INTRODUCTION: Pseudomyxoma peritonei is an infrequent entity, defined by collections of gelatinous material in the abdomen and pelvis and mucinous implants on peritoneum, secondary to the rupture of a mucinous lesion, usually of ovarian or appendiceal origin. MATERIALS AND METHODS: We present our experience of 11 cases (6 males and 5 females) diagnosed with pseudomyxoma peritonei secondary to epithelial appendicular neoplasms over 27 years. The mean age of the patients was 68 years. Clinical manifestations were abdominal distension (55%), right lower quadrant pain (45%) suggesting acute appendicitis and constitutional syndrome (36%). An abdominal mass was detected at physical examination in 4 patients. CT scan revealed a tumour in right iliac fossa in 4 patients, peritoneal enlargement in 1 and a liquid collection in 1. Preoperative diagnosis was acute abdomen in 5 patients, peritoneal carcinomatosis in 3 and undetermined abdominal mass in 3. RESULTS: Surgical findings suggested pseudomyxoma peritonei in 8 patients and peritoneal carcinomatosis in 3. Appendicectomy was performed in 9 patients, and in 3 of them bilateral anexectomy was also performed. One patient underwent ileocaecal resection and another a right hemicolectomy. In all the cases, mucinous material was eliminated as much as possible. Pathology revealed mucinous cystoadenoma in 6 cases, mucinous cystoadenocarcinoma in 3 and epithelial hyperplasia in 2 patients. Median survival was 54 months, with a 5- year survival rate of 40%. The last case we treated was sent to a reference centre for the treatment of pseudomyxoma peritonei. CONCLUSIONS: There is no consensus on the best treatment for pseudomyxoma peritonei. We recommend avoiding incomplete surgical resections in non-reference centres and submitting patients to a reference centre to undergo adequate treatment.

PMID: 18055329 [PubMed - indexed for MEDLINE]
Goblet cell carcinoid of the appendix: a specific type of carcinoma.

Fetched: February 28th, 2008, 9:00pm EST

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Goblet cell carcinoid of the appendix: a specific type of carcinoma.

Histopathology. 2007 Dec;51(6):763-73

Authors: van Eeden S, Offerhaus GJ, Hart AA, Boerrigter L, Nederlof PM, Porter E, van Velthuysen ML

AIMS: Goblet cell carcinoid is a poorly understood tumour of the appendix. The aim of this study was to determine whether it should be regarded as a separate entity or as a variant of classical carcinoid. METHODS AND RESULTS: The immunohistochemical expression pattern of 21 markers and the mutation status of KRas codon 12 were determined in 16 goblet cell carcinoids and compared with 14 classical carcinoids, 19 colonic adenocarcinomas and 10 appendiceal mucinous cystadeno (carcino)mas. The results were subjected to a stepwise linear discriminant analysis. Goblet cell carcinoids were significantly different from the control groups. The most important markers for discriminating between the groups were CEA (classical carcinoid versus all others), KRas mutation (present in all mucinous cystadeno (carcino)mas), beta-catenin (goblet cell carcinoid versus left sided colonic adenocarcinoma) and chromogranin (goblet cell carcinoid versus right sided colonic adenocarcinoma). Expression of Math1 and HD5 was similar in goblet cell carcinoid and colonic adenocarcinoma but absent in classical carcinoid. CONCLUSION: The results suggest that goblet cell carcinoids should be regarded as a separate entity. The formerly used term 'crypt cell carcinoma' may be more appropriate because it reflects the more aggressive clinical behaviour of these tumours as well as their greater similarity to adenocarcinomas rather than to carcinoids.

PMID: 18042066 [PubMed - indexed for MEDLINE]
Mucinous appendiceal neoplasms: preoperative MR staging and classification compared with surgical and histopathologic findings.

Fetched: February 25th, 2008, 9:00pm EST

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Mucinous appendiceal neoplasms: preoperative MR staging and classification compared with surgical and histopathologic findings.

AJR Am J Roentgenol. 2008 Mar;190(3):656-65

Authors: Low RN, Barone RM, Gurney JM, Muller WD

OBJECTIVE: The objective of our study was to determine the accuracy of MRI in the preoperative staging and classification of mucinous appendiceal neoplasms and to describe the MRI features that are useful for selecting patients for surgical resection. MATERIALS AND METHODS: Twenty-two patients underwent preoperative MRI including T1-weighted, T2-weighted, immediate gadolinium-enhanced, and delayed gadolinium-enhanced imaging. Two observers reviewed the images for peritoneal tumor at 13 sites, tumor size and distribution, and degree of tumor enhancement. Peritoneal tumor sites were recorded at surgery. Cytoreduction was categorized as complete or suboptimal. Surgical specimens were classified as disseminated peritoneal adenomucinosis tumors, intermediate-grade tumors, or peritoneal mucinous carcinomatosis tumors. RESULTS: Surgery confirmed 232 tumor sites. Delayed gadolinium-enhanced MRI was the most accurate of the MR techniques, with a sensitivity, specificity, and accuracy of 89%, 87%, and 89%, respectively, for observer 1 and 82%, 87%, and 83% for observer 2 (p < 0.001). Surgical cytoreduction was complete in 14 patients and suboptimal in eight. MRI findings predicting suboptimal cytoreduction included a large (> 5 cm) mesenteric mass, which was present in 75% of the patients in the suboptimal cytoreduction group and 0% of those in the complete cytoreduction group; diffuse mesenteric tumor (88% and 0%, respectively); tumor encasement of mesenteric vessels (88% and 0%); or diffuse small-bowel serosal tumor (75% and 0%). Histopathology results showed six disseminated peritoneal adenomucinosis tumors, four intermediate tumors, and 11 peritoneal mucinous carcinomatosis tumors. The specimens for the remaining patient were not available for histopathologic analysis. Qualitatively, the 11 peritoneal mucinous carcinomatosis tumors showed greater enhancement than the liver, whereas six disseminated peritoneal adenomucinosis and the four intermediate tumors showed less enhancement than the liver. Quantitatively, the mean tumor-to-liver contrast for disseminated peritoneal adenomucinosis and intermediate tumors was 0.67 compared with 1.53 for peritoneal mucinous carcinomatosis tumors (p < 0.0001). CONCLUSION: Of the MR techniques evaluated, delayed gadolinium-enhanced MRI was the most accurate for the staging and classification of mucinous appendiceal neoplasms and provided prognostic information useful for patient selection.

PMID: 18287436 [PubMed - indexed for MEDLINE]
[A case of pseudomyxoma peritonei successfully treated with multidisciplinary treatment including modified FOLFOX6 regimen]

Fetched: February 19th, 2008, 9:00pm EST

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[A case of pseudomyxoma peritonei successfully treated with multidisciplinary treatment including modified FOLFOX6 regimen]

Gan To Kagaku Ryoho. 2007 Nov;34(12):2047-9

Authors: Ishibashi K, Sobajima J, Okada N, Ishizuka N, Yokoyama M, Mitsuhashi T, Miyazaki T, Nakada H, Gonda T, Ishida H

We report a case of pseudomyxoma peritonei caused by carcinoma of the appendix, which was successfully treated with multidisciplinary treatment including modified FOLFOX6 regimen. A 45-year-old man was diagnosed as having peritoneal dissemination associated with cancer of the cecum or appendix. Seven cycles of mFOLFOX6 treatment resulted in a marked decrease in ascites and serum levels of carcinoembryonic antigen and carbohydrate antigen 19-9. At laparotomy, a diagnosis of pseudomyxoma peritonei caused by cancer of the appendix was made. Intraperitoneal lavarge with 10,000 mL 5% glucose was performed after right hemicolectomy, omentectomy and removed of mucinous peritoneal nodules. Intraperitoneal chemotherapy comprised of 3000 mL low molecule dextran and 80 mg cisplatin was added on postoperative days 7 and 14. Modified FOLFOX6 regimen was started again two months postoperatively and reached 28 cycles. The patient does not show any sign of recurrence 12 months postoperatively.

PMID: 18219894 [PubMed - indexed for MEDLINE]
[Mucocele of the appendix]

Fetched: February 19th, 2008, 9:00pm EST

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[Mucocele of the appendix]

Cir Esp. 2007 Nov;82(5):297-300

Authors: Echenique-Elizondo M, Liron de Robles C, Amondarain Arratíbel JA, Aribe X

INTRODUCTION: Mucoceles of the appendix are infrequent entities and are found in only 0.25% of all appendectomies and 8% of all appendicular tumors. MATERIAL AND METHODS: We describe 27 cases of mucocele of the appendix treated at Donostia Hospital between January 1978 and December 2006. RESULTS: The mean age of the patients was 54.4 +/- 21.7 years (range: 17-88). Of the 27 patients, 15 (55.5%) were males and 12 (44.5%) were females. Emergency surgery was performed in 17 patients (62.9%). Mucoceles were identified as operative findings during surgery for other reasons in seven patients (25.9%). Three patients (11.1%) underwent surgery because of a diagnosis of abdominal tumor. The main reason for emergency surgery was lower right abdominal pain in 14 patients (82.2%), intestinal obstruction in one (5.8%), a diagnosis of endometriosis in one (5.8%) and a diagnosis of pyosalpinx in one (5.8%). Three patients underwent surgery due to pseudomyxoma peritonei after 24, 36 and 41 months' follow-up. The third patient is asymptomatic after peritonectomy and a follow-up of 78 months. We found an overall incidence of 11 cases (40.7%) presenting with synchronous or metachronous neoplasms from other locations. CONCLUSIONS: We recommend monitoring of all patients with mucocele of the appendix, because these masses can sometimes be associated with neoplasms in other locations and there is a risk of pseudomyxoma peritonei even after a long follow-up.

PMID: 18021629 [PubMed - indexed for MEDLINE]
Malignant neoplasms of the appendix.

Fetched: February 15th, 2008, 9:00pm EST

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Malignant neoplasms of the appendix.

Int J Colorectal Dis. 2007 Oct;22(10):1239-48

Authors: O'Donnell ME, Badger SA, Beattie GC, Carson J, Garstin WI

BACKGROUND: Appendiceal neoplasms, first described in 1882, are still rare, with pre-operative diagnosis invariably difficult. We present our 10-year experience of these lesions with a review of current epidemiology, pathology and treatment modalities. MATERIALS AND METHODS: A retrospective histopathological review of all appendicectomy specimens was completed between April 1994 and December 2003 to identify patients diagnosed with malignant neoplasms. Patient demographics, operative details, histopathology and clinical outcomes were obtained from case notes. A literature search of the PubMed database was then performed using the medical search headings; appendix, tumour, neoplasm and malignancy. RESULTS: Twenty-two patients (eight men) were identified during the study period, with no age difference between gender (mean age in women 58, range 14-83 vs mean age in men 55, range 16-78). Eleven patients were found to have carcinoid-type tumours, eight patients with adenocarcinomas and three patients with lymphomas. Other appendiceal pathologies were identified after appendicectomies, hemicolectomy and oophorectomy. Mean follow-up was 41 months (range 1-125 months). Fourteen patients were alive at the end of follow-up. Patients with classical carcinoid tumours (CCT) had better outcomes than patients with the goblet cell carcinoid, adenocarcinoma and lymphoma. CONCLUSIONS: From our own experience and a subsequent review of the literature, we recommend right hemicolectomy as the treatment of choice for all malignant appendiceal neoplasms, except for small CCT less than 2 cm in diameter at the tip of the appendix, with a low proliferative index, without angiolymphatic or mesoappendiceal extension. Further adjuvant therapy should be considered after oncological assessment.

PMID: 17447078 [PubMed - indexed for MEDLINE]

Shoreham to have first 'Lax Out Cancer' day
Newsday, NY - May 11, 2008
Carol Zangle is a year survivor of breast cancer and Barbara Heuer is free of appendix cancer for a year and half. Their initials and those of Gerald Logan, ...

Terminally-ill mum in schoolbus dispute - Hucknall Today

Posted: April 24th, 2008, 10:23am EDT

Terminally-ill mum in schoolbus dispute
Hucknall Today, UK - Apr 24, 2008
But within a year, she was given the devastating news that she has a rare and terminal form of appendix cancer. The girls both travel to schools in Arnold. ...

Terminally-ill mum in schoolbus dispute - Hucknall Today

Posted: April 24th, 2008, 10:23am EDT

Terminally-ill mum in schoolbus dispute - Hucknall Today

Posted: April 24th, 2008, 10:23am EDT

Oglala leader will be missed, friends say - Rapid City Journal

Posted: April 2nd, 2008, 4:56pm EDT

Oglala leader will be missed, friends say
Rapid City Journal, SD - Apr 2, 2008
... of the Wawokiya Business Institute and a former Oglala Sioux Tribe councilman, died Monday in Allen after a bout with a rare form of appendix cancer. ...

Researchers study new drug and indications for heated chemotherapy ... - News-Medical.net

Posted: March 17th, 2008, 4:10pm EDT

Researchers study new drug and indications for heated chemotherapy ...
News-Medical.net, Australia - Mar 17, 2008
... rates for select patients with peritoneal carcinoma (cancer of the lining of the abdominal cavity) that has spread from colorectal or appendix cancer. ...

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Researchers Study New Drug And Indications For Heated Chemotherapy ... - Science Daily (press release)

Posted: March 14th, 2008, 6:47pm EDT

Researchers Study New Drug And Indications For Heated Chemotherapy ...
Science Daily (press release) - 2 hours ago
... rates for select patients with peritoneal carcinoma (cancer of the lining of the abdominal cavity) that has spread from colorectal or appendix cancer. ...

Researchers Study New Drug And Indications For Heated Chemotherapy ... - Science Daily (press release)

Posted: March 14th, 2008, 6:47pm EDT

Researchers Study New Drug And Indications For Heated Chemotherapy ...
Science Daily (press release) - Mar 14, 2008
... rates for select patients with peritoneal carcinoma (cancer of the lining of the abdominal cavity) that has spread from colorectal or appendix cancer. ...

Researchers Study New Drug And Indications For Heated Chemotherapy ... - Science Daily (press release)

Posted: March 14th, 2008, 6:47pm EDT

Trial - Appendix Cancer

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CBT-1 and Paclitaxel in Treating Patients With Refractory, Recurrent, or Advanced Metastatic Solid Tumors

Posted: April 12th, 2008, 10:00am EDT

Condition: Cancer
Interventions: Drug: MDR modulator CBT-1; Drug: paclitaxel; Drug: technetium 99m sestamibi; Procedure: chemosensitization/potentiation therapy; Procedure: drug resistance inhibition treatment; Procedure: parenteral chemotherapy; Procedure: radionuclide imaging
Sponsor: National Cancer Institute (NCI)
Recruiting - verified April 2008
Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancer

Posted: April 4th, 2008, 10:00am EDT

Conditions: Anal Cancer; Carcinoma of the Appendix; Colorectal Cancer; Esophageal Cancer; Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Gastric Cancer; Gastrointestinal Carcinoid Tumor; Gastrointestinal Stromal Tumor; Liver Cancer; Pancreatic Cancer; Small Intestine Cancer
Interventions: Drug: fluorouracil; Drug: irinotecan hydrochloride; Drug: leucovorin calcium; Procedure: parenteral chemotherapy; Procedure: pharmacogenomic studies; Procedure: pharmacological study
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Not yet recruiting - verified April 2008
Endoesophageal Cryotherapy For Ablating Barrett's Esophagus and Early Stage Esophageal Cancer

Posted: February 25th, 2008, 10:00am EST

Condition: Barrett's Esophagus
Interventions: Procedure: Endoscopic spray cryotherapy; Procedure: Endoscopic spray cryotherapy
Sponsors: Walter Reed Army Medical Center; CSA Medical, Inc.
Recruiting - verified August 2007
Spirituality/Religiosity in Patients and Caregivers

Posted: February 25th, 2008, 10:00am EST

Conditions: Advanced Cancer; Solid Tumors
Intervention: Behavioral: Questionnaires
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified March 2008

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Rare Cancer News » Appendix Cancer

By Cancer

Appendix Cancer (33 unread)

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