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Trial - CNS Tumor (52 unread)

International Rare Brain Tumor Registry

Posted: January 26th, 2023, 3:00pm GMT

Conditions: Astroblastoma; BCOR ITD Sarcoma; CNS Sarcoma; Unclassified Tumor, Malignant
Intervention:
Sponsor: Children's National Research Institute
Recruiting
Phase II Trial of the PARP Inhibitor Niraparib and PD-1 Inhibitor Dostarlimab in Patients With Advanced Cancers With Active Progressing Brain Metastases (STARLET)

Posted: January 26th, 2023, 3:00pm GMT

Condition: Brain Metastases
Interventions: Drug: Niraparib; Drug: Dostarlimab
Sponsor: M.D. Anderson Cancer Center
Not yet recruiting
Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance

Posted: January 20th, 2023, 3:00pm GMT

Conditions: Brain Metastases; Nonsmall Cell Lung Cancer Stage III
Interventions: Diagnostic Test: MRI of the Brain; Other: Blood draws; Other: Quality of Life Questionnaires
Sponsors: Wake Forest University Health Sciences; National Cancer Institute (NCI)
Not yet recruiting
SILibinin in NSCLC and BC Patients With Single Brain METastasis (SILMET)

Posted: January 19th, 2023, 3:00pm GMT

Conditions: Brain Metastases, Adult; Non Small Cell Lung Cancer; Breast Cancer
Interventions: Dietary Supplement: Silibinin; Other: Placebo
Sponsor: Alessia Pellerino
Recruiting
Microscopy Imaging of Whole-mount Stained Human Tissues

Posted: January 18th, 2023, 3:00pm GMT

Conditions: Tumor, Brain; Tumor, Breast; Tumor Skin
Intervention:
Sponsor: National Taiwan University Hospital
Not yet recruiting
Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Posted: January 16th, 2023, 3:00pm GMT

Conditions: Malignant Glioma of Brain; Astrocytoma; Malignant Astrocytoma; Brain Tumor; Glioma; Brain Cancer; Glioblastoma; Glioblastoma Multiforme; GBM
Intervention: Biological: Ad5-yCD/mutTKSR39rep-ADP adenovirus and fractionated stereotactic radiosurgery (fSRS)
Sponsor: Henry Ford Health System
Recruiting
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Zanubrutinib With Pemetrexed to Treat Relapsed/Refractory Primary and Secondary Central Nervous System (CNS) Lymphomas

Posted: January 12th, 2023, 3:00pm GMT

Conditions: Primary Central Nervous System Lymphoma; Secondary Central Nervous System Lymphoma; Relapsed Cancer; Refractory Cancer
Interventions: Drug: Pemetrexed; Drug: Zanubrutinib; Procedure: Autologous Stem Cell Transplant (ASCT); Radiation: Whole Brain Radiation Therapy (WBRT)
Sponsors: Baptist Health South Florida; BeiGene
Not yet recruiting
Surgical Outcome of Dorsolumbar Intradural Extramedullary Spinal Cord Tumors

Posted: January 10th, 2023, 3:00pm GMT

Condition: Spinal Cord Tumor
Intervention: Procedure: surgical excision
Sponsor: Sohag University
Recruiting
AssesSment of Early deteCtion basEd oN liquiD Biopsy in Intracranial Tumors

Posted: January 10th, 2023, 3:00pm GMT

Condition: Intracranial Tumors
Intervention: Device: early detection test
Sponsors: Zhujiang Hospital; Guangzhou Burning Rock Dx Co., Ltd.
Recruiting
MeFAMP for Imaging System A Amino Acid Transport in Primary and Metastatic Brain Tumors

Posted: January 9th, 2023, 3:00pm GMT

Conditions: Healthy Volunteers; Recurrent Glioma; Brain Metastases From Extra-cranial Solid Tumors
Intervention: Drug: [F-18]MeFAMP PET
Sponsor: University of Alabama at Birmingham
Not yet recruiting
A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)

Posted: January 6th, 2023, 3:00pm GMT

Conditions: Metastatic Solid Tumor; Brain Metastases
Interventions: Drug: Trastuzumab emtansine; Drug: Tucatinib
Sponsors: M.D. Anderson Cancer Center; Genentech, Inc.; Seagen Inc.
Not yet recruiting
Genetic and Molecular Risk Profiles of Pediatric Malignant Brain Tumors in China

Posted: January 5th, 2023, 3:00pm GMT

Conditions: Medulloblastoma; Central Nervous System Tumor, Pediatric; Ependymoma; Germ Cell Tumor; Glioma; Brain Tumor, Pediatric
Intervention:
Sponsor: Beijing Tiantan Hospital
Recruiting
Evaluation of the Contribution of NODDI Protocol Tractography in Brain Tumor Surgery

Posted: December 30th, 2022, 3:00pm GMT

Condition: Malignant Brain Tumor
Intervention: Other: NODDI TRACT
Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche
Not yet recruiting
A Phase 1/2 Study of Oral IRAK-4 Inhibitor CA-4948 in Combination With Pembrolizumab Following Stereotactic Radiosurgery in Patients With Melanoma Brain Metastases

Posted: December 30th, 2022, 3:00pm GMT

Condition: Melanoma Metastatic in the Brain
Interventions: Drug: CA-4948; Drug: Pembrolizumab
Sponsors: University of Florida; Merck Sharp & Dohme LLC
Not yet recruiting
3T MRI of Intramedullary Spinal Cord Tumours

Posted: December 23rd, 2022, 3:00pm GMT

Condition: Spinal Cord Tumor of Cervical Spine
Intervention: Diagnostic Test: MRI scan
Sponsor: University of Oxford
Recruiting
A Phase 1b / 2 Drug Resistant Immunotherapy With Activated, Gene Modified Allogeneic or Autologous γδ T Cells (DeltEx) in Combination With Maintenance Temozolomide in Subjects With Recurrent or Newly Diagnosed Glioblastoma

Posted: December 23rd, 2022, 3:00pm GMT

Condition: Glioblastoma
Interventions: Biological: Autologous genetically modified gamma-delta T cells; Biological: Allogeneic genetically modified gamma-delta T cells
Sponsor: In8bio Inc.
Not yet recruiting
Assessment of the Presence of Symptoms of End-of-life Discomfort and Their Management in Children With a Primary Brain Tumor in the Grand Est Region Impact of the Development of Pediatric Palliative Care

Posted: December 21st, 2022, 3:00pm GMT

Condition: Primary Brain Tumor
Intervention:
Sponsor: University Hospital, Strasbourg, France
Recruiting
Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients

Posted: December 21st, 2022, 3:00pm GMT

Conditions: Brain Tumor; Head and Neck Cancer
Interventions: Radiation: substructure informed planning; Other: Neurocognitive Testing; Diagnostic Test: MRI
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Not yet recruiting
Nasal Outcomes Using Saline Irrigations After Endonasal Pituitary Surgery

Posted: December 21st, 2022, 3:00pm GMT

Condition: Pituitary Tumor
Intervention: Other: Nasal saline irrigation
Sponsors: Nicole Hill; Barrow Brain and Spine
Recruiting
Pilot Trial of Autologous Tumor Infiltrating Lymphocytes (LN-144) for Patients With Asymptomatic Melanoma Brain Metastases

Posted: December 7th, 2022, 3:00pm GMT

Condition: Metastatic Melanoma
Intervention: Biological: Lifileucel (LN-144)
Sponsors: Memorial Sloan Kettering Cancer Center; Iovance Biotherapeutics, Inc.
Recruiting
A Window of Opportunity Study of Patritumab Deruxtecan in Patients With Brain Metastases

Posted: November 17th, 2022, 3:00pm GMT

Condition: Brain Metastases, Adult
Intervention: Drug: Patritumab deruxtecan
Sponsors: Mustafa Khasraw, MBChB, MD, FRCP, FRACP; Daiichi Sankyo, Inc.
Not yet recruiting
A Study Called ARAMON to Learn to What Extent Does Study Treatment With Darolutamide Affects Testosterone Levels in Men With Prostate Cancer That Had Not Been Treated With Hormonal Therapy Compared to Treatment With Enzalutamide

Posted: September 2nd, 2022, 2:00pm GMT

Condition: Biochemically Recurrent Prostate Cancer
Interventions: Drug: Darolutamide(BAY1841788, Nubeqa); Drug: Enzalutamide
Sponsor: Bayer
Recruiting
Precision Medicine for Every Child With Cancer

Posted: August 17th, 2022, 2:00pm GMT

Conditions: Childhood Cancer; Childhood Solid Tumor; Childhood Brain Tumor; Childhood Leukemia; Refractory Cancer; Relapsed Cancer
Interventions: Genetic: Whole Genome Sequencing; Genetic: RNA seq; Genetic: DNA Methylation; Genetic: Targeted Panel Sequencing; Genetic: High Throughput Sequencing (in vitro); Genetic: Patient Derived Xenograft (PDX)(in vivo); Other: Liquid Biopsy
Sponsors: Australian & New Zealand Children's Haematology/Oncology Group; Children's Cancer Institute; Minderoo Foundation; Medical Research Future Fund
Recruiting
Oral AMXT 1501 Dicaprate in Combination With IV DFMO

Posted: August 15th, 2022, 2:00pm GMT

Conditions: Cancer; Solid Tumor; Solid Carcinoma; Advanced Cancer; DIPG Brain Tumor; Ovary Cancer; Breast Cancer; Papillary Thyroid Cancer; Head and Neck Cancer; Gastric Cancer; Nsclc; Mesotheliomas Pleural; Mesothelioma Peritoneum; Esophageal Cancer; Diffuse Midline Glioma, H3 K27M-Mutant; Endometrial Cancer; Cervical Cancer; Melanoma; Colorectal Cancer
Interventions: Drug: AMXT1501; Drug: DFMO
Sponsor: Aminex Therapeutics, Inc.
Recruiting
Characterizing Sleep Among Long-term Survivors of Childhood Cancer

Posted: July 29th, 2022, 2:00pm GMT

Conditions: ALL, Adult; CNS Tumor; Solid Tumor
Interventions: Other: Neurocognitive (Thinking) Testing; Diagnostic Test: CNS Vital Signs (Thinking) Testing; Other: Health Questionnaires, Sleep Surveys & Sleep Diary; Diagnostic Test: Echocardiography/EKG; Diagnostic Test: Pulmonary Function; Device: Remote Polysomnography; Diagnostic Test: Physical Function
Sponsor: St. Jude Children's Research Hospital
Not yet recruiting
Post Market Clinical Follow-Up Study on the Performance and Safety of Lyoplant®

Posted: July 1st, 2022, 2:00pm GMT

Conditions: Tumor, Cerebral Ventricle; Tumor, Cerebellar; Aneurysm Cerebral; Trauma, Brain
Intervention: Device: Lyoplant®
Sponsor: Aesculap AG
Not yet recruiting
Propranolol and Von Hippel-Lindau Disease

Posted: June 21st, 2022, 2:00pm GMT

Conditions: Hemangioblastoma of CNS; Von Hippel-Lindau Disease
Interventions: Drug: Propranolol; Other: follow-up
Sponsors: Assistance Publique - Hôpitaux de Paris; Agence Générale des Equipements et Produits de Santé
Recruiting
Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors

Posted: June 7th, 2022, 2:00pm GMT

Conditions: Atypical Teratoid Rhabdoid Tumor; INI1 (SMARCB1)-Deficient Primary CNS Malignant Tumors; SMARCA4-deficient Primary CNS Malignant Tumors; Malignant Rhabdoid Tumor (MRT); Rhabdoid Tumor of the Kidney (RTK); Epithelioid Sarcoma; Chordoma
Interventions: Drug: Tazemetostat; Drug: Nivolumab; Drug: Ipilimumab
Sponsors: Susan Chi, MD; Bristol-Myers Squibb; Epizyme, Inc.
Recruiting
Study of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to HR+/HER2- Breast Cancer

Posted: May 23rd, 2022, 2:00pm GMT

Conditions: Breast Neoplasms; Brain Neoplasms; Neoplasms by Site; Neoplasms; Breast Diseases; Central Nervous System Neoplasms; Brain Diseases; Central Nervous System Diseases
Interventions: Drug: Elacestrant; Drug: Abemaciclib
Sponsor: Stemline Therapeutics, Inc.
Recruiting
[68Ga]Ga-PentixaFor PET Imaging in CNS Lymphoma Patients

Posted: February 3rd, 2022, 3:00pm GMT

Condition: CNS Lymphoma
Intervention: Drug: 68Ga-PTF
Sponsor: PentixaPharm GmbH
Recruiting
WBSI Guided Personalized Delivery of TTFields

Posted: October 21st, 2021, 2:00pm GMT

Conditions: GBM; Glioma Glioblastoma Multiforme; Tumor, Brain
Intervention: Diagnostic Test: Whole Brain Spectroscopy Imaging Array Mapping Layout
Sponsors: Abramson Cancer Center of the University of Pennsylvania; NovoCure Ltd.; National Institutes of Health (NIH); National Cancer Institute (NCI)
Recruiting
Intra-Arterial Chemotherapy for Newly Diagnosed, Residual, or Recurrent Atypical Choroid Plexus Papilloma and Choroid Plexus Carcinoma Prior to Second-Look Surgery

Posted: August 6th, 2021, 2:00pm GMT

Conditions: Atypical Choroid Plexus Papilloma; Choroid Plexus Carcinoma
Interventions: Drug: Melphalan; Drug: Carboplatin; Drug: Topotecan
Sponsor: Weill Medical College of Cornell University
Recruiting
Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology

Posted: August 3rd, 2021, 2:00pm GMT

Conditions: Central Nervous System Neoplasm; Leptomeningeal Neoplasm; Metastatic Malignant Neoplasm in the Brain; Primary Brain Neoplasm
Interventions: Other: Electronic Health Record Review; Other: Survey Administration
Sponsor: M.D. Anderson Cancer Center
Recruiting
Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

Posted: July 26th, 2021, 2:00pm GMT

Condition: Glioblastoma Multiforme
Interventions: Drug: Pembrolizumab; Radiation: Stereotactic Radiation Therapy; Procedure: Surgical Resection
Sponsors: Chirag G. Patil; Merck Sharp & Dohme LLC; National Cancer Institute (NCI)
Recruiting
WHOle Brain Irradiation or STEreotactic Radiosurgery for Five or More Brain Metastases (WHOBI-STER)

Posted: May 18th, 2021, 2:00pm GMT

Conditions: Neurocognitive Deficit; Quality of Life; Activities of Daily Living
Interventions: Radiation: Stereotactic RadioTherapy; Radiation: Whole Brain Irradiation
Sponsors: Mediterranean Institute of Oncology; University of Messina; University of Palermo
Recruiting
Surgical Resection of Latent Brain Tumors Prior to Recurrence

Posted: March 23rd, 2021, 2:00pm GMT

Condition: Brain Neoplasm
Intervention: Procedure: Brain Surgery
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting
A Study to Evaluate Chemotherapy Plus Osimertinib Against Chemotherapy Plus Placebo in Patients With Non-small Cell Lung Cancer (NSCLC)

Posted: February 21st, 2021, 3:00pm GMT

Condition: Non-small Cell Lung Cancer
Interventions: Drug: Osimertinib (AZD9291) pemetrexed cisplatin or carboplatin; Drug: Placebo for osimertinib (AZD9291) pemetrexed cisplatin or carboplatin
Sponsors: AstraZeneca; Parexel
Recruiting
Central Nervous System Disorders Following Hematopoietic Stem Cell Transplantation

Posted: February 4th, 2021, 3:00pm GMT

Conditions: Central Nervous System Infections; Central Nervous System Complication; Infectious Disease of Nervous System; Blood Disease; Blood Cancer; Infection
Intervention:
Sponsor: European Society for Blood and Marrow Transplantation
Recruiting
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

Posted: August 12th, 2020, 2:00pm GMT

Conditions: Acral Lentiginous Melanoma; Clinical Stage IV Cutaneous Melanoma AJCC v8; Metastatic Cutaneous Melanoma; Metastatic Malignant Neoplasm in the Brain; Metastatic Melanoma; Metastatic Mucosal Melanoma; Pathologic Stage IV Cutaneous Melanoma AJCC v8
Interventions: Drug: Binimetinib; Drug: Encorafenib; Biological: Ipilimumab; Biological: Nivolumab
Sponsors: Southwest Oncology Group; National Cancer Institute (NCI)
Recruiting
Pre- Versus Post-operative SRS for Resectable Brain Metastases

Posted: July 17th, 2020, 2:00pm GMT

Condition: Brain Metastases
Interventions: Procedure: Brain Surgery; Radiation: Stereotactic Radiosurgery
Sponsor: AHS Cancer Control Alberta
Recruiting
MR Imaging Study Using the Northern Alberta Linac-MR (Northern LIGHTs - 1)

Posted: April 24th, 2020, 2:00pm GMT

Condition: Cancer
Intervention: Device: MR scan with the Alberta linac-MR P3 system
Sponsor: AHS Cancer Control Alberta
Recruiting
Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer

Posted: April 16th, 2020, 2:00pm GMT

Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Malignant Neoplasm in the Brain; Metastatic Triple-Negative Breast Carcinoma; Prognostic Stage IV Breast Cancer AJCC v8
Interventions: Biological: Anti-HER2/HER3 Dendritic Cell Vaccine; Biological: Pembrolizumab
Sponsors: Roswell Park Cancer Institute; United States Department of Defense
Recruiting
Electronic Social Network Assessment Program (eSNAP) + Caregiver Navigator

Posted: February 13th, 2020, 3:00pm GMT

Condition: Brain Cancer
Interventions: Behavioral: eSNAP; Behavioral: Caregiver Navigator
Sponsor: H. Lee Moffitt Cancer Center and Research Institute
Recruiting
A Brain Metastases Research Platform to Tackle the Challenge of CNS Metastases in Solid Tumours

Posted: September 30th, 2019, 2:00pm GMT

Condition: CNS Metastases
Interventions: Other: Samples collection: Plasma; Other: Samples collection: CSF; Other: Samples collection: Non-CNS Metastatic Tumour Tissue; Other: Brain MRI; Other: Samples collection: Serum
Sponsors: Jules Bordet Institute; La Fondation contre le cancer, Belgique; Les Amis de l'Institut Bordet; Bristol-Myers Squibb; Fondation Cancer, Luxembourg
Recruiting
C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)

Posted: September 23rd, 2019, 2:00pm GMT

Conditions: Diffuse Intrinsic Pontine Glioma; High Grade Glioma; Embryonal Tumor; Ependymal Tumor
Interventions: Genetic: (C7R)-GD2.CART cells; Drug: Cyclophosphamide; Drug: Fludarabine
Sponsors: Baylor College of Medicine; Center for Cell and Gene Therapy, Baylor College of Medicine; The Faris Foundation
Recruiting
Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases

Posted: November 15th, 2018, 3:00pm GMT

Conditions: Malignant Neoplasm; Metastatic Malignant Neoplasm in the Brain
Interventions: Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Radiation: Stereotactic Radiosurgery
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting
Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery

Posted: September 19th, 2018, 2:00pm GMT

Condition: Pituitary Neoplasm
Intervention: Other: ESC
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting
RAD 1802: Pilot Trial of Dose Adapted Stereotactic Body Radiotherapy for Early Stage Breast Cancer Patients Eligible for Post-Operative Accelerated Partial Breast Irradiation (APBI)

Posted: August 23rd, 2018, 2:00pm GMT

Condition: Breast Cancer
Intervention: Radiation: 1-3 Fraction Stereotactic Body Radiation Therapy
Sponsor: University of Alabama at Birmingham
Recruiting
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Posted: February 6th, 2018, 3:00pm GMT

Conditions: Recurrent Glioblastoma Multiforme; Primary Glioblastoma Multiforme; Brain Neoplasms, Malignant; Leptomeningeal Disease (LMD)
Interventions: Radiation: Radiation Therapy; Drug: AZD1390
Sponsor: AstraZeneca
Recruiting
Evaluation of the Efficacy and Safety of Nal-IRI for Progressing Brain Metastases in Breast Cancer Patients

Posted: November 1st, 2017, 2:00pm GMT

Condition: Breast Cancer Metastatic
Intervention: Drug: Irinotecan Hydrochloride
Sponsor: MedSIR
Recruiting
$Permalink for 'Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors'$
Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors

Posted: December 31st, 2015, 3:00pm GMT

Conditions: Diffuse Intrinsic Pontine Glioma; Brain Tumor, Recurrent; Solid Tumor, Recurrent; Neuroblastoma, Recurrent, Refractory; Ewing Sarcoma, Recurrent, Refractory; Rhabdomyosarcoma, Recurrent, Refractory; Osteosarcoma, Recurrent, Refractory; Rhabdoid Tumor, Recurrent, Refractory
Intervention: Drug: Abemaciclib
Sponsor: Emory University
Recruiting
Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas

Posted: November 13th, 2014, 3:00pm GMT

Conditions: Pituitary Neoplasms; Adenoma
Intervention: Drug: cabergoline
Sponsors: St. Olavs Hospital; Norwegian University of Science and Technology
Recruiting

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Rare Cancer News & Clinical Trials » Trial - CNS Tumor

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Trial - CNS Tumor (52 unread)

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