Conditions: Brain Metastases; HR+ Metastatic Breast Cancer
Interventions: Radiation: Stereotactic Radiosurgery (SRS); Drug: Abemaciclib; Drug: Endocrine therapy
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; Eli Lilly and Company
Not yet recruiting
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Acinar Cell Carcinoma
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Adrenal Gland Cancer
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Ampulla Of Vater
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Anal Cancer
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Angiosarcoma
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Brain and CNS
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Carcinoid
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Endocrine/Neuroendocrine
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Hemangioendothelioma
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Hepatoblastoma
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Pancreas
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PMP and Mucinous Tumors
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Sarcoma
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Trial - CNS Tumor (100 unread)
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Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases
Posted: June 11th, 2021, 2:00pm GMT
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CBT for Insomnia in Primary Brain Tumor Patients
Posted: June 9th, 2021, 2:00pm GMT
Conditions: Primary Brain Tumor; PBT
Intervention: Behavioral: Cognitive Behavioral Therapy-Insomnia
Sponsor: Virginia Commonwealth University
Not yet recruiting -
Histomolecular Profiles of Gliomas in Children and Adolescent/Young Adults
Posted: June 7th, 2021, 2:00pm GMT
Conditions: Histological; Molecular Sequence Variation; Glioma
Intervention:
Sponsor: Centre Hospitalier Universitaire, Amiens
Recruiting -
Surveillance of Association of Immune Status and Prognosis of CNS Germ Cell Tumor Survivors
Posted: May 31st, 2021, 2:00pm GMT
Conditions: Intracranial Germ Cell Tumor; Intracranial Germ Cell CNS Tumor, Childhood; Surgery
Intervention:
Sponsor: Chengcheng Guo
Recruiting -
Acalabrutinib in CNSL
Posted: May 28th, 2021, 2:00pm GMT
Conditions: Central Nervous System Lymphoma; Refractory Central Nervous System Lymphoma; Recurrent Central Nervous System Lymphoma
Intervention: Drug: Acalabrutinib
Sponsor: Dana-Farber Cancer Institute
Not yet recruiting -
Paxalisib (GDC-0084) In Recurrent Or Refractory PCNSL
Posted: May 28th, 2021, 2:00pm GMT
Conditions: Primary Central Nervous System Lymphoma; Non-Hodgkin Lymphoma of Extranodal Site
Intervention: Drug: PAXALISIB
Sponsors: Lakshmi Nayak; Kazia Therapeutics Limited
Recruiting -
Almonertinib Combined With Cerebral Radiation Treat Brain Metastases From EGFR Positive NSCLC
Posted: May 27th, 2021, 2:00pm GMT
Condition: Non-Small Cell Lung Cancer (NSCLC)
Interventions: Drug: Almonertinib; Radiation: Stereotactic Radiotherapy(SRT) or Stereotactic Radiosurgery(SRS) or Whole-Brain Radiotherapy(WBRT)
Sponsor: Chongqing University Cancer Hospital
Recruiting -
Intrathecal Chemotherapy for Central Nervous System Metastasis in Retinoblastoma
Posted: May 26th, 2021, 2:00pm GMT
Condition: Neoplasm Metastases of Retinoblastoma
Intervention: Drug: Melphalan
Sponsors: Eye & ENT Hospital of Fudan University; Zhongshan Ophthalmic Center, Sun Yat-sen University; Children's Hospital of Fudan University
Recruiting -
Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors
Posted: May 26th, 2021, 2:00pm GMT
Conditions: Solid Tumor, Adult; Brain Tumor, Primary; Desmoplastic Small Round Cell Tumor
Intervention: Drug: PBI-200
Sponsor: Pyramid Biosciences
Not yet recruiting -
Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
Posted: May 25th, 2021, 2:00pm GMT
Conditions: Brain Cancer; Brain Metastases; Melanoma; Lung Cancer; Breast Cancer; HER2-positive Breast Cancer; Colorectal Cancer; Gastrointestinal Cancer; SRS; SRT; Whole Brain Radiation; Stereotactic Radiation; AGuIX; Nanoparticle; Cystic; Brain Tumor
Interventions: Radiation: Stereotactic Radiation; Drug: AGuIX gadolinium-based nanoparticles; Other: Placebo
Sponsors: Dana-Farber Cancer Institute; NH TherAguix SAS
Not yet recruiting -
Detection and Metabolic Characterization in DOPA PET/CT of Brain Metastases
Posted: May 18th, 2021, 2:00pm GMT
Conditions: Brain Metastases; MRI
Intervention: Radiation: F-DOPA PET/CT
Sponsor: Institut Cancerologie de l'Ouest
Not yet recruiting -
Durvalumab (MEDI4736) and Radiosurgery (fSRT vs. PULSAR) for the Treatment of Non-Small Cell Lung Cancer Brain Metastases
Posted: May 17th, 2021, 2:00pm GMT
Condition: Brain Metastases From Non-small Cell Lung Cancer
Interventions: Radiation: Stereotactic Radiation Therapy; Drug: Durvalumab
Sponsor: University of Texas Southwestern Medical Center
Not yet recruiting -
A Study of Brigatinib to Treat Adults With Anaplastic Lymphoma Kinase (ALK) Positive Metastatic Non Small Cell Lung Cancer (NSCLC)
Posted: May 14th, 2021, 2:00pm GMT
Conditions: Carcinoma, Non-Small-Cell Lung; Anaplastic Lymphoma Kinase
Intervention: Other: No Intervention
Sponsor: Takeda
Recruiting -
CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma
Posted: May 4th, 2021, 2:00pm GMT
Conditions: Diffuse Midline Glioma, H3 K27M-Mutant; Metastatic Malignant Neoplasm in the Central Nervous System; Recurrent Diffuse Intrinsic Pontine Glioma; Recurrent Lymphoma; Recurrent Malignant Solid Neoplasm; Recurrent Osteosarcoma; Recurrent Primary Malignant Central Nervous System Neoplasm; Refractory Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Osteosarcoma; Refractory Primary Malignant Central Nervous System Neoplasm
Intervention: Drug: FACT Complex-targeting Curaxin CBL0137
Sponsor: Children's Oncology Group
Not yet recruiting -
Efficiency and Safety of Different Treatment Strategies in Adults With Pituitary Adenomas With Hypothalamic Involvement
Posted: April 28th, 2021, 2:00pm GMT
Condition: Pituitary Adenoma
Interventions: Procedure: Total resection; Procedure: Staged resection; Procedure: Subtotal resection followed by stereotactic radiation therapy
Sponsor: Wuhan Union Hospital, China
Not yet recruiting -
Tranexamic Acid for Blood Loss Minimization in Endoscopic Pituitary Surgery
Posted: April 28th, 2021, 2:00pm GMT
Conditions: Pituitary Tumor; Blood Loss; Surgery
Interventions: Drug: Tranexamic acid; Drug: Placebo
Sponsor: University of North Carolina, Chapel Hill
Not yet recruiting -
Pediatric Prospective Personalized Immune and Target Identification Trial
Posted: April 26th, 2021, 2:00pm GMT
Conditions: Central Nervous System Neoplasms; Pediatric Cancer; GEN1 Gene Mutation; Tumor, Brain
Intervention: Device: FoundationOneHeme
Sponsors: Masaryk University; Brno University Hospital; Roche s.r.o.
Recruiting -
Evaluation of Neratinib for Treatment and Prevention of Subsequent CNS Event(s) in Patients With Brain Metastasis of Advanced HER2 Positive Breast Cancer
Posted: April 23rd, 2021, 2:00pm GMT
Conditions: Breast Cancer; Brain Metastases
Intervention: Drug: Neratinib
Sponsor: Jules Bordet Institute
Not yet recruiting -
Dose-staged Gamma Knife Radiosurgery Versus Microsurgical Resection
Posted: April 23rd, 2021, 2:00pm GMT
Condition: Brain Metastases
Interventions: Procedure: Microsurgical resection; Procedure: Gamma Knife radiosurgery
Sponsor: Medical University of Vienna
Recruiting -
Tissue Collection for Drug Screening and Bioanalysis
Posted: April 21st, 2021, 2:00pm GMT
Conditions: Pediatric Central Nervous System Tumor; Central Nervous System Tumor
Intervention:
Sponsor: Weill Medical College of Cornell University
Recruiting -
Intraoperative Radiotherapy in Patients With Brain Metastases
Posted: April 19th, 2021, 2:00pm GMT
Condition: Brain Metastases
Intervention: Radiation: Intraoperative radiotherapy
Sponsor: Parc de Salut Mar
Recruiting -
Efficacy and Safety of High Dose Aprepitant Treatment in Patients With Advanced Non-Small Cell Lung Cancer
Posted: April 9th, 2021, 2:00pm GMT
Conditions: Non Small Cell Lung Cancer; Advanced Cancer; Refractory Cancer
Intervention: Drug: Aprepitant
Sponsors: PlusVitech S.L.; ECONiX Araştırma Analiz ve Danışmanlık A.Ş.
Recruiting -
ASL in Brain Metastasis MRI Following Gamma Knife Treatment
Posted: April 6th, 2021, 2:00pm GMT
Condition: Brain Metastases
Intervention: Other: MRI perfusion sequence
Sponsor: Assistance Publique - Hôpitaux de Paris
Not yet recruiting -
Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung Cancer
Posted: April 6th, 2021, 2:00pm GMT
Conditions: Leptomeningeal Metastasis; Lung Cancer
Intervention: Drug: Nimotuzumab
Sponsor: Hui Bu
Recruiting -
A Tailored Exercise Oncology Program for Neuro-Oncology Patients
Posted: April 5th, 2021, 2:00pm GMT
Conditions: Cancer; Brain Tumor, Primary
Intervention: Behavioral: Tailored Exercise Intervention
Sponsors: University of Calgary; Alberta Cancer Foundation; University of Alberta; Tom Baker Cancer Centre; Cross Cancer Institute
Not yet recruiting -
A Prospective Clinical Study of BTK Inhibitor, PD-1 and Formustine in the First-line Treatment of Primary Central Nervous System Lymphoma
Posted: April 5th, 2021, 2:00pm GMT
Condition: Primary Central Nervous System Lymphoma
Intervention: Drug: Orelabrutinib combined with PD-1 and fotemustine
Sponsor: Mingzhi Zhang
Recruiting -
Keynatinib in Treated Patients With NSCLC and Brain Metastases
Posted: April 1st, 2021, 2:00pm GMT
Conditions: Non-Small Cell Lung Cancer With EGFR Mutation; Brain Metastases
Intervention: Drug: Keynatinib
Sponsor: Medolution Ltd.
Recruiting -
Surgical Resection of Latent Brain Tumors Prior to Recurrence
Posted: March 23rd, 2021, 2:00pm GMT
Condition: Brain Neoplasm
Interventions: Procedure: Brain Surgery; Other: Quality-of-Life Assessment
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting -
A Neurocognitive Study in Patients With Brain Oligometastases Receiving Hypofractionated SRT
Posted: March 18th, 2021, 2:00pm GMT
Condition: Brain Metastases, Adult
Intervention: Radiation: Hypofractionated Stereotactic Radiotherapy
Sponsor: Chang Gung Memorial Hospital
Not yet recruiting -
Safety and Oversight of the Individually Tailored Treatment Approach: A Novel Pilot Study
Posted: March 17th, 2021, 2:00pm GMT
Condition: Cancer
Interventions: Drug: Trametinib; Drug: Cobimetinib; Drug: Binimetinib; Drug: Alpelisib; Drug: Vemurafenib; Drug: Dabrafenib; Drug: Encorafenib; Drug: Palbociclib; Drug: Olaparib; Drug: Ribociclib; Drug: Abemaciclib; Drug: Talazoparib; Drug: Nivolumab; Drug: Atezolizumab; Drug: Pembrolizumab
Sponsor: Peter MacCallum Cancer Centre, Australia
Recruiting -
ETMR One: An International Registry and Research Platform for Children With Embryonal Tumor With Multilayer Rosettes
Posted: March 12th, 2021, 3:00pm GMT
Condition: Embryonal Tumor With Multilayered Rosettes
Intervention:
Sponsor: Hackensack Meridian Health
Recruiting -
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome
Posted: March 11th, 2021, 3:00pm GMT
Conditions: Uveal Melanoma; Cutaneous Melanoma; BAP1 Gene Mutation; Renal Cell Carcinoma; Mesothelioma; Hepatocellular Carcinoma; Cholangiocarcinoma; Meningioma Atypical
Intervention:
Sponsor: Mohamed Abdel-Rahman
Recruiting -
Glutamate Excitotoxicity in Brain Metastases From Lung, Breast and Melanoma Treated With Stereotactic Radiosurgery
Posted: March 8th, 2021, 3:00pm GMT
Condition: Brain Metastases, Adult
Interventions: Radiation: Stereotactic radiosurgery; Diagnostic Test: Blood samples
Sponsor: IRCCS San Raffaele
Recruiting -
Stereotactic Radiotherapy in Association With Immunotherapy for the Treatment of NSCLC Brain Metastases
Posted: March 8th, 2021, 3:00pm GMT
Condition: Brain Metastases From NSCLC
Intervention: Radiation: Valutation of toxicity
Sponsor: Azienda Ospedaliero-Universitaria Careggi
Recruiting -
Infraorbital Nerve Block for Endoscopic Transsphenoidal Approach to Remove Pituitary Tumor
Posted: March 5th, 2021, 3:00pm GMT
Condition: Intraoperative Pain Control
Intervention: Drug: dexmedetomidine 5 mcg mixed with 0.5% plain bupivacaine
Sponsor: Chiang Mai University
Not yet recruiting -
Transnasal Endoscopic Pituitary Surgery - the Effect of Posterior Nasal Septum Resection on Nasal Functions
Posted: March 4th, 2021, 3:00pm GMT
Condition: Pituitary Adenoma
Intervention: Procedure: Posterium nasal septum resection
Sponsor: University Hospital Ostrava
Recruiting -
A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY)
Posted: March 3rd, 2021, 3:00pm GMT
Conditions: NSCLC; Brain Metastases; Leptomeningeal Metastasis
Interventions: Drug: almonertinib; Drug: LM-first line treatment; Drug: LM-second line treatment
Sponsor: Henan Cancer Hospital
Not yet recruiting -
Multimodality MRI and Liquid Biopsy in GBM
Posted: March 2nd, 2021, 3:00pm GMT
Conditions: Glioblastoma Multiforme; Brain Tumor, Adult: Glioblastoma; Brain Tumor, Recurrent; Brain Tumor, Primary
Intervention: Diagnostic Test: Post Feraheme Infusion MRI
Sponsor: University of Pennsylvania
Not yet recruiting -
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Patients With ALK Fusion-Positive Solid or CNS Tumors
Posted: March 1st, 2021, 3:00pm GMT
Condition: ALK Fusion-positive Solid or CNS Tumors
Intervention: Drug: Alectinib
Sponsor: Hoffmann-La Roche
Not yet recruiting -
A Study of Avapritinib in Pediatric Patients With Relapsed or Refractory Solid Tumors With a Mutation in KIT or PDGFRA
Posted: February 26th, 2021, 3:00pm GMT
Conditions: Solid Tumor, Unspecified, Child; Relapsed Solid Neoplasm; CNS Tumor
Intervention: Drug: avapritinib
Sponsor: Blueprint Medicines Corporation
Not yet recruiting -
Molecular Characterization of Genetic Alterations in Pediatric Solid Tumors
Posted: February 26th, 2021, 3:00pm GMT
Condition: Pediatric Solid Tumors
Intervention:
Sponsor: National Council of Scientific and Technical Research, Argentina
Recruiting -
Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors
Posted: February 25th, 2021, 3:00pm GMT
Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8; Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8; Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8; Locally Advanced Malignant Solid Neoplasm; Locally Advanced Melanoma; Locally Advanced Primary Malignant Central Nervous System Neoplasm; Locally Advanced Sarcoma; Metastatic Malignant Solid Neoplasm; Metastatic Melanoma; Metastatic Primary Malignant Central Nervous System Neoplasm; Metastatic Sarcoma; Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8; Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8; Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8; Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8; Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8; Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8; Prognostic Stage IIIC Breast Cancer AJCC v8; Prognostic Stage IV Breast Cancer AJCC v8; Stage IIIC Colorectal Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Colorectal Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8
Intervention: Drug: Avapritinib
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting -
MEP and Neuromuscular Blocker
Posted: February 24th, 2021, 3:00pm GMT
Condition: Brain Tumor
Intervention: Drug: Arm I (MEP)
Sponsor: Gangnam Severance Hospital
Recruiting -
A Study to Evaluate Chemotherapy Plus Osimertinib Against Chemotherapy Plus Placebo in Patients With Non-small Cell Lung Cancer (NSCLC)
Posted: February 22nd, 2021, 3:00pm GMT
Condition: Non-small Cell Lung Cancer
Interventions: Drug: Osimertinib (AZD9291) pemetrexed cisplatin or carboplatin; Drug: Placebo for osimertinib (AZD9291) pemetrexed cisplatin or carboplatin
Sponsors: AstraZeneca; Parexel
Not yet recruiting -
Tumor Heterogeneity in Diffuse Large B-cell Lymphoma in Relation to CNS Involvement and Cell-free DNA
Posted: February 19th, 2021, 3:00pm GMT
Condition: Lymphoma, Large B-Cell, Diffuse
Intervention:
Sponsor: Herlev Hospital
Not yet recruiting -
Study of the Inflammatory Microenvironment in Atypical Meningiomas
Posted: February 19th, 2021, 3:00pm GMT
Condition: Atypical Meningioma
Intervention:
Sponsor: Central Hospital, Nancy, France
Recruiting -
A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme
Posted: February 19th, 2021, 3:00pm GMT
Condition: Glioblastoma Multiforme, Adult
Interventions: Drug: Berubicin; Drug: Lomustine
Sponsors: CNS Pharmaceuticals, Inc.; Worldwide Clinical Trials
Recruiting -
TKIs vs. Pertuzumab in HER2+ Breast Cancer Patients With Active Brain Metastases (HER2BRAIN)
Posted: February 18th, 2021, 3:00pm GMT
Conditions: HER2-positive Breast Cancer; Brain Metastases
Interventions: Drug: Trastuzumab; Drug: Taxanes; Drug: Pertuzumab; Drug: Tyrosine kinase inhibitor
Sponsors: Second Affiliated Hospital, School of Medicine, Zhejiang University; Peking University International Hospital; Sun Yat-sen University; Zhejiang University
Not yet recruiting -
SGM-101 in Colorectal Brain Metastases.
Posted: February 16th, 2021, 3:00pm GMT
Conditions: Rectal Neoplasms; Rectum Cancer; Colorectal Neoplasms; Brain Metastases; Brain Neoplasms; Brain Diseases; Brain Cancer; Brain Tumor; Intestinal Neoplasms; Gastrointestinal Neoplasms; Gastrointestinal Cancer; Gastrointestinal Disease; Intestinal Disease
Intervention: Drug: SGM-101
Sponsors: Leiden University Medical Center; Medical Center Haaglanden; Surgimab
Not yet recruiting -
Comparison of Different Approaches for Supraclavicular Block and Their Effects on Diaphragm Muscle Function
Posted: February 16th, 2021, 3:00pm GMT
Conditions: Phrenic Nerve Paralysis; Diaphragm Sellae Meningioma; Complications; Respiratory Complication; Nerve Block; Brachial Plexus Block
Interventions: Drug: Bupivacaine HCl 0.5% Injectable Solution; Drug: Prilocaine HCl % 2 injectable solution; Drug: adrenaline amp 0.5mg; Procedure: Ultrasound Guided Supraclavicular Block Corner pocket approach; Procedure: Ultrasound Guided Supraclavicular Block Corner pocket + intracluster approach; Procedure: Ultrasound Guided Supraclavicular Block multi approach; Procedure: diagraphma muscle evaluation with ultrasound
Sponsor: Bozyaka Training and Research Hospital
Not yet recruiting -
18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastases
Posted: February 12th, 2021, 3:00pm GMT
Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Clinical Stage IV Cutaneous Melanoma AJCC v8; Glioma; Malignant Brain Neoplasm; Metastatic Breast Carcinoma; Metastatic Colon Carcinoma; Metastatic Kidney Carcinoma; Metastatic Lung Carcinoma; Metastatic Malignant Neoplasm in the Brain; Metastatic Melanoma; Pathologic Stage IV Cutaneous Melanoma AJCC v8; Prognostic Stage IV Breast Cancer AJCC v8; Stage IV Colon Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v8; Stage IVA Colon Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Colon Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8; Stage IVC Colon Cancer AJCC v8
Interventions: Procedure: Computed Tomography; Drug: 18F-FMAU; Procedure: Multiparametric Magnetic Resonance Imaging; Procedure: Positron Emission Tomography
Sponsors: University of Southern California; National Cancer Institute (NCI)
Recruiting -
Genomic Study in Non-small Cell Lung Cancer Brain Metastasis
Posted: February 9th, 2021, 3:00pm GMT
Conditions: NSCLC Stage IV; Brain Metastases
Intervention: Procedure: craniectomy
Sponsor: National Cheng-Kung University Hospital
Recruiting -
A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas
Posted: February 9th, 2021, 3:00pm GMT
Conditions: Glioma; Glioma Intracranial; Gliomas Benign; Brain Tumor; Brain Cancer; Motor Cortex; Lesion
Intervention: Device: RNS System Implantation
Sponsor: Medical College of Wisconsin
Not yet recruiting -
CNS Dose Escalation/Expansion of Tepotinib in MET-driven NSCLC
Posted: February 4th, 2021, 3:00pm GMT
Condition: Advanced Non-Small Cell Lung Cancer With MET Mutations
Intervention: Drug: Tepotinib
Sponsors: Criterium, Inc.; EMD Serono Research & Development Institute, Inc.
Not yet recruiting -
ONC206 for Treatment of Newly Diagnosed or Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant Brain Tumors (PNOC 023)
Posted: February 1st, 2021, 3:00pm GMT
Conditions: Diffuse Midline Glioma (DMG); Malignant Brain Tumors; Glioblastoma; Recurrent Ependymoma; Recurrent Malignant Brain Neoplasm; Spinal Cord Glioma; WHO Grade III Glioma
Interventions: Drug: ONC206; Radiation: Standard of Care Radiation Therapy
Sponsors: Sabine Mueller, MD, PhD; Chimerix; Mithil Prasad Foundation; Storm the Heavens Fund; The ChadTough Defeat DIPG Foundation
Not yet recruiting -
Study of [68Ga]-FF58 in Patients With Selected Solid Tumors Expected to Overexpress αvβ3 and αvβ5 Integrins.
Posted: January 15th, 2021, 3:00pm GMT
Conditions: Glioblastoma Multiforme; Brain Neoplasms
Intervention: Drug: 68Ga-FF58
Sponsor: Novartis Pharmaceuticals
Not yet recruiting -
LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)
Posted: January 7th, 2021, 3:00pm GMT
Conditions: Glioma; Glioblastoma; Brain Tumor
Interventions: Procedure: LITT; Radiation: Hypofractionated Radiation Therapy
Sponsors: University of Maryland, Baltimore; Keep Punching Foundation
Recruiting -
Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study
Posted: December 30th, 2020, 3:00pm GMT
Condition: Recurrent Brain Metastases
Interventions: Procedure: Craniotomy; Radiation: Cesium-131 brachytherapy
Sponsors: Memorial Sloan Kettering Cancer Center; GT Medical Technologies, Inc.
Recruiting -
Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery
Posted: December 30th, 2020, 3:00pm GMT
Conditions: Brain Metastases, Adult; Brain Metastases; Brain Cancer
Intervention: Drug: 18F fluciclovine
Sponsors: Baptist Health South Florida; Blue Earth Diagnostics
Not yet recruiting -
A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
Posted: December 24th, 2020, 3:00pm GMT
Conditions: Central Nervous System Nongerminomatous Germ Cell Tumor; Choriocarcinoma; Embryonal Carcinoma; Immature Teratoma; Malignant Teratoma; Mixed Germ Cell Tumor; Pineal Region Germ Cell Tumor; Pineal Region Immature Teratoma; Pineal Region Yolk Sac Tumor; Suprasellar Germ Cell Tumor
Interventions: Drug: Carboplatin; Drug: Etoposide; Biological: Filgrastim; Drug: Ifosfamide; Drug: Mesna; Biological: Pegfilgrastim; Procedure: Peripheral Blood Stem Cell Transplantation; Other: Questionnaire Administration; Radiation: Radiation Therapy; Procedure: Second-Look Surgery; Drug: Thiotepa
Sponsor: Children's Oncology Group
Not yet recruiting -
HM-178: Assessing Methods for Improvement in Methotrexate Toxicity Management and Detection of Central Nervous System Involvement of Aggressive Lymphoma
Posted: December 16th, 2020, 3:00pm GMT
Condition: Lymphoma
Intervention: Drug: Glucarpidase
Sponsor: Fox Chase Cancer Center
Recruiting -
Stereotactic Radiosurgery and Immunotherapy (Pembrolizumab) for the Treatment of Recurrent Meningioma
Posted: December 9th, 2020, 3:00pm GMT
Conditions: Grade I Meningioma, Adult; Grade II Meningioma, Adult; Grade III Meningioma, Adult; Recurrent Meningioma
Interventions: Drug: Pembrolizumab; Procedure: Stereotactic Radiosurgery
Sponsors: Nancy Ann Oberheim Bush, MD; Merck Sharp & Dohme Corp.
Recruiting -
A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases
Posted: October 27th, 2020, 2:00pm GMT
Condition: Carcinoma, Non-Small-Cell Lung
Interventions: Drug: Entrectinib; Drug: Crizotinib
Sponsor: Hoffmann-La Roche
Not yet recruiting -
The Safety of Intravenous Tranexamic Acid in Patients Undergoing Supratentorial Meningiomas Resection
Posted: October 22nd, 2020, 2:00pm GMT
Conditions: Seizures; Meningioma
Interventions: Drug: Tranexamic acid; Drug: 0.9% saline
Sponsor: Beijing Tiantan Hospital
Recruiting -
Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease
Posted: October 19th, 2020, 2:00pm GMT
Conditions: HER2-positive Breast Cancer; Leptomeningeal Metastasis; Leptomeningeal Disease
Interventions: Radiation: Radiation Therapy; Drug: Pertuzumab; Drug: Trastuzumab
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; Genentech, Inc.
Recruiting -
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a p53 Y220C Mutation
Posted: October 14th, 2020, 2:00pm GMT
Conditions: Advanced Solid Tumor; Advanced Malignant Neoplasm; Metastatic Cancer; Metastatic Solid Tumor
Intervention: Drug: PC14586
Sponsor: PMV Pharmaceuticals, Inc
Recruiting -
Changes in the MRI Signal in Patients With Benign Tumors of the Brain and Meninges Treated With Proton Therapy: Impact of TEL and the Biological Dose Received
Posted: October 12th, 2020, 2:00pm GMT
Conditions: Benign Brain Tumors; Proton Therapy
Intervention: Device: MRI 3 tesla
Sponsor: Centre Francois Baclesse
Recruiting -
Survivorship Study of Cancer Patients Who Received Cranial Radiation Therapy
Posted: September 28th, 2020, 2:00pm GMT
Conditions: Brain Metastases, Adult; Primary Brain Tumor; Lung Cancer
Interventions: Drug: Namzaric®; Drug: Placebo
Sponsors: Duke University; Allergan; Varian Medical Systems
Not yet recruiting -
A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement
Posted: September 10th, 2020, 2:00pm GMT
Conditions: Malignant Melanoma; Carcinoma, Non-Small-Cell Lung; Brain Neoplasms, Primary; Brain Neoplasms; Malignant Neoplasms
Interventions: Drug: PF-07284890; Drug: Binimetinib; Drug: Midazolam
Sponsor: Pfizer
Recruiting -
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Posted: September 9th, 2020, 2:00pm GMT
Conditions: Central Nervous System Neoplasms; Glioblastoma; Gliosarcoma, Adult; Anaplastic Oligodendroglioma; Anaplastic Astrocytoma; Pilocytic Astrocytoma; Oligodendroglioma; Gliomatosis Cerebri; Pleomorphic Xanthoastrocytoma; Anaplastic Pleomorphic Xanthoastrocytoma; Diffuse Midline Glioma, H3 K27M-Mutant; Ependymoma; Ependymoma, Anaplastic; Medulloblastoma; Teratoid Rhabdoid Tumor; Neuroectodermal Tumors, Primitive; Neuroectodermal Tumors; Anaplastic Meningioma; Atypical Meningioma; Choroid Plexus Neoplasms; Pineal Tumor; Diffuse Astrocytoma; Glial Tumor
Intervention: Drug: ONC206
Sponsors: Chimerix; National Institutes of Health (NIH)
Recruiting -
TOPAZ: Tucatinib in COmbination With Pembrolizumab And TrastuZumab in Patients With HER2-Positive Breast Cancer Brain Metastases
Posted: August 13th, 2020, 2:00pm GMT
Conditions: Breast Cancer; Brain Metastases; HER2-positive Breast Cancer; CNS Disease
Interventions: Drug: Tucatinib; Drug: Pembrolizumab; Drug: Trastuzumab
Sponsors: Reva Basho; Merck Sharp & Dohme Corp.; Seagen Inc.
Recruiting -
Apatinib in the Treatment of Recurrent Atypical/Malignant Meningioma in Adults
Posted: August 6th, 2020, 2:00pm GMT
Condition: Recurrent Atypical/Malignant Meningioma
Intervention: Drug: Apatinib Mesylate
Sponsor: Beijing Sanbo Brain Hospital
Recruiting -
Controlling Coordination After Childhood Cerebellar Cancer, a Pilot Study
Posted: August 6th, 2020, 2:00pm GMT
Condition: Brain Cancer
Interventions: Other: Transcranial Magnetic Stimulation (TMS); Other: Magnetic Resonance Imaging (MRI); Other: Motor assessment; Other: Questionnaires
Sponsors: University of Nottingham; Nottingham University Hospital NHS Trust; Nottingham Hospitals Charity
Not yet recruiting -
Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study
Posted: August 5th, 2020, 2:00pm GMT
Conditions: Constitutional Mismatch Repair Deficiency Syndrome; Hematopoietic and Lymphoid Cell Neoplasm; Lynch Syndrome; Recurrent Lymphoma; Recurrent Malignant Solid Neoplasm; Recurrent Neuroblastoma; Recurrent Primary Central Nervous System Neoplasm; Refractory Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Neuroblastoma; Refractory Primary Central Nervous System Neoplasm; Xeroderma Pigmentosum
Interventions: Procedure: Biospecimen Collection; Biological: Ipilimumab; Biological: Nivolumab
Sponsor: National Cancer Institute (NCI)
Recruiting -
Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy
Posted: July 21st, 2020, 2:00pm GMT
Conditions: Pediatric Cancer; CNS Tumor, Childhood; Skin Inflammation
Interventions: Other: Warm Baths or Showers; Other: Moisturizer; Drug: SPF 30 or Higher Suncreen; Other: Sun Protective Clothing; Behavioral: Limited Sun Exposure; Other: Dilute bleach baths
Sponsor: Dana-Farber Cancer Institute
Recruiting -
Cancer Genetic Testing in Ethnic Populations
Posted: July 17th, 2020, 2:00pm GMT
Conditions: Breast Carcinoma; Carcinoma of Unknown Primary; Central Nervous System Carcinoma; Digestive System Carcinoma; Genitourinary System Carcinoma; Head and Neck Carcinoma; Malignant Brain Neoplasm; Malignant Female Reproductive System Neoplasm; Malignant Musculoskeletal Neoplasm; Malignant Solid Neoplasm; Skin Carcinoma
Interventions: Procedure: Biospecimen Collection; Other: Genetic Testing
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting -
18F-fluciclovine PET/MRI Imaging for the Detection of Tumor Recurrence After Radiation Injury to the Brain
Posted: July 8th, 2020, 2:00pm GMT
Conditions: Metastatic Intracranial Malignant Neoplasm; Recurrent Intracranial Neoplasm
Interventions: Radiation: Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Positron Emission Tomography; Other: Fluciclovine F18
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting -
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
Posted: June 11th, 2020, 2:00pm GMT
Conditions: Brain Tumor, Recurrent; Brain Tumor; Brain Tumor, Primary; Brain Tumor - Metastatic; Brain Tumor, Adult: Glioblastoma; Brain Tumor, Adult Meningioma
Intervention: Device: GammaTile
Sponsor: GT Medical Technologies, Inc.
Recruiting -
Pembrolizumab, Ibrutinib and Rituximab in PCNSL
Posted: June 9th, 2020, 2:00pm GMT
Conditions: Primary Central Nervous System Lymphoma; Recurrent Cancer
Interventions: Drug: Ibrutinib; Drug: Pembrolizumab; Drug: Rituximab
Sponsors: Dana-Farber Cancer Institute; Merck Sharp & Dohme Corp.
Recruiting -
Study to Establish Image Interpretation Criteria for 18F Fluciclovine PET in Detecting Recurrent Brain Metastases (PURSUE)
Posted: June 1st, 2020, 2:00pm GMT
Condition: Brain Metastases
Intervention: Drug: 18F fluciclovine
Sponsors: Blue Earth Diagnostics; Precision For Medicine
Recruiting -
Study to Establish the Diagnostic Performance of 18F Fluciclovine PET in Detecting Recurrent Brain Metastases
Posted: June 1st, 2020, 2:00pm GMT
Condition: Brain Metastases
Intervention: Drug: 18F fluciclovine
Sponsors: Blue Earth Diagnostics; Precision For Medicine
Recruiting -
Safety Study of Pritumumab in Brain Cancer
Posted: May 21st, 2020, 2:00pm GMT
Conditions: Malignant Primary Brain Tumors; Brain Metastases, Adult
Intervention: Biological: Pritumumab
Sponsors: Nascent Biotech; Hoag Memorial Hospital Presbyterian
Recruiting -
Innovative Trial for Understanding the Impact of Targeted Therapies in NF2
Posted: May 5th, 2020, 2:00pm GMT
Conditions: Neurofibromatosis Type 2; Vestibular Schwannoma; Non-vestibular Schwannoma; Meningioma; Ependymoma
Intervention: Drug: Brigatinib
Sponsors: Scott R. Plotkin, MD, PhD; Takeda; The Children's Tumor Foundation
Recruiting -
Copeptin as a Biomarker for Central Diabetes Insipidus Development Following Pituitary Surgery
Posted: April 30th, 2020, 2:00pm GMT
Conditions: Sellar and Suprasellar Masses; Pituitary Tumor
Intervention:
Sponsor: Mayo Clinic
Recruiting -
Research of Biomarkers of Response to Proton Beam Therapy in Pediatric and Adult Patients.
Posted: April 29th, 2020, 2:00pm GMT
Conditions: Brain Cancer; Meningioma; Sarcoma
Intervention:
Sponsor: Centre Leon Berard
Recruiting -
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases
Posted: April 13th, 2020, 2:00pm GMT
Conditions: Brain Metastases, Adult; Neurocognitive Function; Cancer
Intervention: Radiation: Cognitive Sparing Brain Stereotactic Radiosurgery (SRS)
Sponsors: Jona Hattangadi-Gluth; National Institutes of Health (NIH); National Cancer Institute (NCI)
Recruiting -
Memory Neuroimaging in Children, Adolescents and Young Adults Following Pediatric Cancer
Posted: March 27th, 2020, 2:00pm GMT
Conditions: Cancer Brain; Pediatric Cancer
Interventions: Device: MRI; Behavioral: Cognitive assessment
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Recruiting -
Direct Comparison of Ga-68-DOTATATE and Ga-68-DOTATOC
Posted: March 6th, 2020, 3:00pm GMT
Condition: Meningioma
Interventions: Drug: Ga-68- DOTATATE; Drug: Ga-68-DOTATOC
Sponsors: Weill Medical College of Cornell University; Cornell University
Recruiting -
Hypofractionated Proton Therapy for Benign Intracranial Brain Tumors, the HiPPI Study
Posted: February 20th, 2020, 3:00pm GMT
Conditions: Grade I Meningioma; Grade II Meningioma; Grade III Meningioma; Intracranial Neoplasm; Nerve Sheath Neoplasm; Pituitary Gland Adenoma; Schwannoma
Interventions: Radiation: Hypofractionated Radiation Therapy; Radiation: Photon Beam Radiation Therapy; Radiation: Proton Beam Radiation Therapy; Other: Quality-of-Life Assessment; Other: Questionnaire Administration
Sponsors: Emory University; National Cancer Institute (NCI)
Recruiting -
Electronic Social Network Assessment Program (eSNAP) + Caregiver Navigator
Posted: February 13th, 2020, 3:00pm GMT
Condition: Brain Cancer
Interventions: Behavioral: eSNAP; Behavioral: Caregiver Navigator
Sponsor: H. Lee Moffitt Cancer Center and Research Institute
Recruiting -
The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) in Pediatrics Undergoing Posterior Fossa Tumor Surgery
Posted: January 18th, 2020, 3:00pm GMT
Conditions: Infratentorial Neoplasms; Hyperventilation; Craniotomy
Intervention: Device: cerebral oximetry
Sponsor: Kasr El Aini Hospital
Recruiting -
Metabolic Characterization of Space Occupying Lesions of the Brain
Posted: January 18th, 2020, 3:00pm GMT
Conditions: Brain Tumor; Glioma; IDH Mutation
Intervention: Device: MR-scans using a 3T Prisma and a 7T Terra scanner (Siemens, Erlangen Germany)
Sponsors: University Hospital Inselspital, Berne; Swiss National Science Foundation
Recruiting -
Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors
Posted: January 3rd, 2020, 3:00pm GMT
Conditions: Malignant Central Nervous System Neoplasm; Primary Central Nervous System Neoplasm
Interventions: Behavioral: Cogstate Assessment Battery; Drug: Memantine; Drug: Memantine Hydrochloride
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting -
Detection of PitNET Tissue During TSS Using Bevacizumab-800CW
Posted: December 30th, 2019, 3:00pm GMT
Conditions: Pituitary Tumor; Pituitary Adenoma; Pituitary Macroadenoma
Interventions: Drug: Bevacizumab-IRDye800CW; Device: Molecular Fluorescence Endoscopy platform
Sponsor: University Medical Center Groningen
Recruiting -
Brain Imaging Biomarkers in Patients With Brain Metastasis
Posted: December 13th, 2019, 3:00pm GMT
Condition: Brain Metastases, Adult
Intervention: Diagnostic Test: CT and MRI Scans
Sponsor: University Health Network, Toronto
Not yet recruiting -
GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases
Posted: December 10th, 2019, 3:00pm GMT
Conditions: Brain Metastases; Leptomeningeal Metastasis
Interventions: Drug: GDC-0084; Radiation: whole brain radiation therapy radiation
Sponsors: Memorial Sloan Kettering Cancer Center; Kazia Therapeutics
Recruiting -
MiDura-Study (Neuro-Patch in Duraplasty)
Posted: December 6th, 2019, 3:00pm GMT
Conditions: Meningioma; Tumor, Brain; Chiari Malformation; Vascular Malformation; Hydrocephalus; Tethered Cord; Dural Fistula; Craniotomy; Spinal Surgery; Duraplasty
Intervention:
Sponsor: Aesculap AG
Recruiting -
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
Posted: December 4th, 2019, 3:00pm GMT
Conditions: Central Nervous System Tumor; Diffuse Intrinsic Pontine Glioma; Diffuse Midline Glioma; Ependymoma; Medulloblastoma, Childhood; Germ Cell Tumor; Atypical Teratoid/Rhabdoid Tumor; Primitive Neuroectodermal Tumor; Choroid Plexus Carcinoma; Pineoblastoma, Childhood; Glioma
Intervention: Biological: SCRI-CARB7H3(s); B7H3-specific chimeric antigen receptor (CAR) T cel
Sponsor: Seattle Children's Hospital
Recruiting -
Novel Gamma-Delta (γδ)T Cell Therapy for Treatment of Patients With Newly Diagnosed Glioblastoma
Posted: November 18th, 2019, 3:00pm GMT
Condition: Brain Tumor Adult
Intervention: Biological: DRI cell therapy
Sponsors: University of Alabama at Birmingham; In8bio Inc.
Recruiting -
3D Printed Mask for GBM and Brain Mets
Posted: October 3rd, 2019, 2:00pm GMT
Condition: Brain Cancer
Interventions: Device: 3D-printed mask; Device: Thermoplastic mask
Sponsor: University Health Network, Toronto
Recruiting