Condition: Glioma
Intervention: Biological: ctDNA analysis
Sponsor: Hospices Civils de Lyon
Not yet recruiting
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The circTeloDIAG: Liquid Biopsy for Glioma Tumor
Posted: June 18th, 2021, 2:00pm GMT
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6 Months Adjuvant Temozolomide (TMZ) vs No Adjuvant TMZ in Newly Diagnosed MGMT Methylated Glioblastoma (GBM)
Posted: June 15th, 2021, 2:00pm GMT
Condition: MGMT-Methylated Glioblastoma
Interventions: Other: Delay of TMZ; Other: Standard of Care (SOC) Adjuvant TMZ (no intervention
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Not yet recruiting -
A Study to Learn About the Awareness and Knowledge That Doctors Have About the Safety and Safe Use Information for Androcur and Other Cyproterone Acetate Treatments in Europe
Posted: June 14th, 2021, 2:00pm GMT
Conditions: Signs of Androgenisation in Women, e.g. Hirsutism, Androgenetic Alopecia, Acne and Seborrhea; Hypersexuality in Men; Sexual Deviations in Men; Prostate Cancer
Intervention: Drug: Cyproterone Acetate (Androcur, BAY94-8367)
Sponsor: Bayer
Not yet recruiting -
Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases
Posted: June 11th, 2021, 2:00pm GMT
Conditions: Brain Metastases; HR+ Metastatic Breast Cancer
Interventions: Radiation: Stereotactic Radiosurgery (SRS); Drug: Abemaciclib; Drug: Endocrine therapy
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; Eli Lilly and Company
Not yet recruiting -
SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma
Posted: June 11th, 2021, 2:00pm GMT
Conditions: Low-Grade Glioma; Recurrent Low-Grade Glioma; Progressive Low-Grade Glioma
Intervention: Drug: Mirdametinib
Sponsors: St. Jude Children's Research Hospital; SpringWorks Therapeutics, Inc.
Recruiting -
CBT for Insomnia in Primary Brain Tumor Patients
Posted: June 9th, 2021, 2:00pm GMT
Conditions: Primary Brain Tumor; PBT
Intervention: Behavioral: Cognitive Behavioral Therapy-Insomnia
Sponsor: Virginia Commonwealth University
Not yet recruiting -
Histomolecular Profiles of Gliomas in Children and Adolescent/Young Adults
Posted: June 7th, 2021, 2:00pm GMT
Conditions: Histological; Molecular Sequence Variation; Glioma
Intervention:
Sponsor: Centre Hospitalier Universitaire, Amiens
Recruiting -
Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma
Posted: June 3rd, 2021, 2:00pm GMT
Conditions: High Grade Glioma; Diffuse Intrinsic Pontine Glioma
Interventions: Biological: Dendritic cell vaccination + temozolomide-based chemoradiation; Biological: Dendritic cell vaccination +- conventional next-line treatment
Sponsors: University Hospital, Antwerp; Kom Op Tegen Kanker; Stichting Semmy; Olivia fund
Not yet recruiting -
Spectroscopic MRI Guided Proton Therapy in Assessing Metabolic Change in Pediatric Patients With Brain Tumors
Posted: May 31st, 2021, 2:00pm GMT
Condition: Malignant Brain Glioma
Interventions: Procedure: Magnetic Resonance Spectroscopic Imaging; Device: Proton Therapy
Sponsors: Emory University; National Cancer Institute (NCI)
Recruiting -
Almonertinib Combined With Cerebral Radiation Treat Brain Metastases From EGFR Positive NSCLC
Posted: May 27th, 2021, 2:00pm GMT
Condition: Non-Small Cell Lung Cancer (NSCLC)
Interventions: Drug: Almonertinib; Radiation: Stereotactic Radiotherapy(SRT) or Stereotactic Radiosurgery(SRS) or Whole-Brain Radiotherapy(WBRT)
Sponsor: Chongqing University Cancer Hospital
Recruiting -
Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors
Posted: May 26th, 2021, 2:00pm GMT
Conditions: Solid Tumor, Adult; Brain Tumor, Primary; Desmoplastic Small Round Cell Tumor
Intervention: Drug: PBI-200
Sponsor: Pyramid Biosciences
Not yet recruiting -
HER2-specific CAR T Cells for Children With Ependymoma
Posted: May 26th, 2021, 2:00pm GMT
Condition: Ependymoma
Intervention: Biological: HER-2 Specific CAR T Cell
Sponsors: Pediatric Brain Tumor Consortium; Texas Children's Cancer Center; Baylor College of Medicine
Not yet recruiting -
A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma
Posted: May 25th, 2021, 2:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme
Interventions: Drug: Ferumoxytol injection; Drug: Pharmacological ascorbate; Radiation: External beam radiation therapy; Drug: Temozolomide
Sponsors: Bryan Allen; Holden Comprehensive Cancer Center
Not yet recruiting -
Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
Posted: May 25th, 2021, 2:00pm GMT
Conditions: Brain Cancer; Brain Metastases; Melanoma; Lung Cancer; Breast Cancer; HER2-positive Breast Cancer; Colorectal Cancer; Gastrointestinal Cancer; SRS; SRT; Whole Brain Radiation; Stereotactic Radiation; AGuIX; Nanoparticle; Cystic; Brain Tumor
Interventions: Radiation: Stereotactic Radiation; Drug: AGuIX gadolinium-based nanoparticles; Other: Placebo
Sponsors: Dana-Farber Cancer Institute; NH TherAguix SAS
Not yet recruiting -
Troriluzole or Placebo Plus Ipi Plus Nivo in Mel Brain Mets
Posted: May 25th, 2021, 2:00pm GMT
Conditions: Melanoma; Metastatic Melanoma
Interventions: Drug: Ipilimumab; Drug: Nivolumab; Drug: Troriluzole; Drug: Placebo
Sponsors: Dana-Farber Cancer Institute; Biohaven Pharmaceuticals, Inc.
Not yet recruiting -
Radiosurgery Before Surgery for the Treatment of Brain Metastases
Posted: May 20th, 2021, 2:00pm GMT
Conditions: Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Solid Neoplasm
Interventions: Drug: Dexamethasone; Procedure: Resection; Radiation: Stereotactic Radiosurgery
Sponsors: Emory University; National Cancer Institute (NCI)
Not yet recruiting -
WHOle Brain Irradiation or STEreotactic Radiosurgery for Five or More Brain Metastases (WHOBI-STER)
Posted: May 18th, 2021, 2:00pm GMT
Conditions: Neurocognitive Deficit; Quality of Life; Activities of Daily Living
Interventions: Radiation: Stereotactic RadioTherapy; Radiation: Whole Brain Irradiation
Sponsors: Mediterranean Institute of Oncology; University of Messina; University of Palermo
Recruiting -
Detection and Metabolic Characterization in DOPA PET/CT of Brain Metastases
Posted: May 18th, 2021, 2:00pm GMT
Conditions: Brain Metastases; MRI
Intervention: Radiation: F-DOPA PET/CT
Sponsor: Institut Cancerologie de l'Ouest
Not yet recruiting -
Durvalumab (MEDI4736) and Radiosurgery (fSRT vs. PULSAR) for the Treatment of Non-Small Cell Lung Cancer Brain Metastases
Posted: May 17th, 2021, 2:00pm GMT
Condition: Brain Metastases From Non-small Cell Lung Cancer
Interventions: Radiation: Stereotactic Radiation Therapy; Drug: Durvalumab
Sponsor: University of Texas Southwestern Medical Center
Not yet recruiting -
Neuro-pharmacological Study of Ketoconazole for High-grade Gliomas
Posted: May 3rd, 2021, 2:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme; Glioblastoma Multiforme of Brain; Glioblastoma Multiforme, Adult
Intervention: Drug: Ketoconazole
Sponsor: Milton S. Hershey Medical Center
Not yet recruiting -
[18F] FDOPA PET Imaging in Glioma
Posted: May 3rd, 2021, 2:00pm GMT
Condition: Glioma
Intervention: Diagnostic Test: Fluorodopa PET tracer
Sponsors: University College, London; Cancer Research UK; University of Oxford
Not yet recruiting -
Finding New Targets by Proteomic Approaches (InnovRT1)
Posted: May 3rd, 2021, 2:00pm GMT
Condition: ATRT
Intervention: Biological: Mass spectrometry
Sponsors: Assistance Publique - Hôpitaux de Paris; Institut Curie; Sainte Anne
Not yet recruiting -
Advanced MRI Scan Before and After Radiation Therapy for the Detection of Intracranial Metastasis
Posted: May 3rd, 2021, 2:00pm GMT
Conditions: Malignant Solid Neoplasm; Metastatic Malignant Neoplasm in the Brain
Interventions: Procedure: Advanced Magnetic Resonance Imaging; Procedure: Conventional Magnetic Resonance Imaging
Sponsor: M.D. Anderson Cancer Center
Recruiting -
Efficiency and Safety of Different Treatment Strategies in Adults With Pituitary Adenomas With Hypothalamic Involvement
Posted: April 28th, 2021, 2:00pm GMT
Condition: Pituitary Adenoma
Interventions: Procedure: Total resection; Procedure: Staged resection; Procedure: Subtotal resection followed by stereotactic radiation therapy
Sponsor: Wuhan Union Hospital, China
Not yet recruiting -
Tranexamic Acid for Blood Loss Minimization in Endoscopic Pituitary Surgery
Posted: April 28th, 2021, 2:00pm GMT
Conditions: Pituitary Tumor; Blood Loss; Surgery
Interventions: Drug: Tranexamic acid; Drug: Placebo
Sponsor: University of North Carolina, Chapel Hill
Not yet recruiting -
HyperSpectral Imaging in Low Grade Glioma
Posted: April 26th, 2021, 2:00pm GMT
Condition: Low Grade Glioma of Brain
Intervention: Device: Hyperspectral Imaging with Snapscan camera
Sponsors: Universitaire Ziekenhuizen Leuven; Imec; Carl Zeiss Meditec AG
Not yet recruiting -
Pediatric Prospective Personalized Immune and Target Identification Trial
Posted: April 26th, 2021, 2:00pm GMT
Conditions: Central Nervous System Neoplasms; Pediatric Cancer; GEN1 Gene Mutation; Tumor, Brain
Intervention: Device: FoundationOneHeme
Sponsors: Masaryk University; Brno University Hospital; Roche s.r.o.
Recruiting -
Dose-staged Gamma Knife Radiosurgery Versus Microsurgical Resection
Posted: April 23rd, 2021, 2:00pm GMT
Condition: Brain Metastases
Interventions: Procedure: Microsurgical resection; Procedure: Gamma Knife radiosurgery
Sponsor: Medical University of Vienna
Recruiting -
Evaluation of Neratinib for Treatment and Prevention of Subsequent CNS Event(s) in Patients With Brain Metastasis of Advanced HER2 Positive Breast Cancer
Posted: April 23rd, 2021, 2:00pm GMT
Conditions: Breast Cancer; Brain Metastases
Intervention: Drug: Neratinib
Sponsor: Jules Bordet Institute
Not yet recruiting -
ONC201 and Radiation Therapy Before Surgery for the Treatment of Recurrent Glioblastoma
Posted: April 22nd, 2021, 2:00pm GMT
Conditions: Recurrent Glioblastoma; Recurrent Gliosarcoma; Recurrent Supratentorial Glioblastoma; Supratentorial Gliosarcoma
Interventions: Drug: Akt/ERK Inhibitor ONC201; Radiation: Radiation Therapy; Procedure: Resection
Sponsors: Jonsson Comprehensive Cancer Center; National Cancer Institute (NCI); Oncoceutics, Inc.; University of California, Los Angeles
Not yet recruiting -
Intraoperative Radiotherapy in Patients With Brain Metastases
Posted: April 19th, 2021, 2:00pm GMT
Condition: Brain Metastases
Intervention: Radiation: Intraoperative radiotherapy
Sponsor: Parc de Salut Mar
Recruiting -
CURATE.AI COR-Tx Trial for Post Brain Radiotherapy Patients
Posted: April 19th, 2021, 2:00pm GMT
Condition: Cognitive Decline
Intervention: Device: CURATE.AI
Sponsors: National University Hospital, Singapore; National University, Singapore; The N.1 Institute for Health (N.1)
Not yet recruiting -
Engineered TILs/CAR-TILs to Treat Advanced Solid Tumors
Posted: April 13th, 2021, 2:00pm GMT
Conditions: Liver Cancer; Lung Cancer; Breast Cancer; Colo-rectal Cancer; Brain Tumor; Solid Tumor, Adult; PD1; CTLA4
Intervention: Biological: TILs and CAR-TILs targeting HER2, Mesothelin, PSCA, MUC1, Lewis-Y, GPC3, AXL, EGFR, Claudin18.2/6, ROR1, GD1, or B7-H3
Sponsors: Second Affiliated Hospital of Guangzhou Medical University; Guangdong Zhaotai InVivo Biomedicine Co. Ltd.
Recruiting -
Efficacy and Safety of High Dose Aprepitant Treatment in Patients With Advanced Non-Small Cell Lung Cancer
Posted: April 9th, 2021, 2:00pm GMT
Conditions: Non Small Cell Lung Cancer; Advanced Cancer; Refractory Cancer
Intervention: Drug: Aprepitant
Sponsors: ECONiX Araştırma Analiz ve Danışmanlık A.Ş.; PlusVitech S.L.
Recruiting -
Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)
Posted: April 8th, 2021, 2:00pm GMT
Conditions: Postoperative Cognitive Dysfunction; Postoperative Delirium; Frailty
Interventions: Device: Near Infrared Spectroscopy (NIRS); Diagnostic Test: Blood sample; Diagnostic Test: Addenbrooke Cognitive Examination III (ACE-III); Diagnostic Test: Confusion Assessment Method
Sponsor: Istanbul University
Recruiting -
ASL in Brain Metastasis MRI Following Gamma Knife Treatment
Posted: April 6th, 2021, 2:00pm GMT
Condition: Brain Metastases
Intervention: Other: MRI perfusion sequence
Sponsor: Assistance Publique - Hôpitaux de Paris
Not yet recruiting -
A Tailored Exercise Oncology Program for Neuro-Oncology Patients
Posted: April 5th, 2021, 2:00pm GMT
Conditions: Cancer; Brain Tumor, Primary
Intervention: Behavioral: Tailored Exercise Intervention
Sponsors: University of Calgary; Alberta Cancer Foundation; University of Alberta; Tom Baker Cancer Centre; Cross Cancer Institute
Not yet recruiting -
Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy
Posted: April 2nd, 2021, 2:00pm GMT
Condition: Limited Stage Small Cell Lung Cancer
Interventions: Other: MRI Surveillance; Radiation: Prophylactic Cranial Irradiation
Sponsor: Shandong Cancer Hospital and Institute
Recruiting -
Neurocognition in NSCLC Patients Treated With Osimertinib or Osimertinib + WBI
Posted: April 2nd, 2021, 2:00pm GMT
Condition: Neurocognitive
Interventions: Radiation: Osimertinib and whole-brain irradiation; Drug: Osimertinib
Sponsor: Sun Yat-sen University
Recruiting -
Neuro-pharmacological Study of Posaconazole for High-grade Gliomas: A Phase 0 Clinical Trial
Posted: April 1st, 2021, 2:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme; Glioblastoma Multiforme of Brain; Glioblastoma Multiforme, Adult
Intervention: Drug: Posaconazole Pill
Sponsor: Milton S. Hershey Medical Center
Not yet recruiting -
Keynatinib in Treated Patients With NSCLC and Brain Metastases
Posted: April 1st, 2021, 2:00pm GMT
Conditions: Non-Small Cell Lung Cancer With EGFR Mutation; Brain Metastases
Intervention: Drug: Keynatinib
Sponsor: Medolution Ltd.
Recruiting -
Analysis of Cell Count, Viability, and Immunogenicity of Discarded Newly Diagnosed Glioblastoma Tissue or Solid Tumor Tissues
Posted: March 30th, 2021, 2:00pm GMT
Conditions: Glioblastoma; Malignant Solid Neoplasm
Intervention: Procedure: Biospecimen Collection
Sponsor: Thomas Jefferson University
Recruiting -
Phase II Trial Evaluating the Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma
Posted: March 26th, 2021, 2:00pm GMT
Conditions: Glioblastoma; Gliosarcoma; Malignant Glioma
Interventions: Drug: TMZ; Drug: ipilimumab 3mg/kg; Drug: Nivolumab; Drug: ipilimumab 1mg/kg
Sponsor: National Cancer Institute (NCI)
Not yet recruiting -
Cognitive Training and Brain Stimulation in Women With Post-chemotherapy Cognitive Impairment
Posted: March 26th, 2021, 2:00pm GMT
Conditions: Breast Cancer; Cognitive Impairment
Interventions: Device: Anodal tDCS; Device: Sham tDCS; Behavioral: Intensive cognitive training
Sponsors: University Medicine Greifswald; University of Greifswald
Not yet recruiting -
Breast Cancer, Reasoning, and Activity Intervention
Posted: March 25th, 2021, 2:00pm GMT
Conditions: Breast Cancer; Breast Neoplasms
Interventions: Behavioral: Aerobic Exercise Training; Other: Health Education (Active comparator)
Sponsor: University of Nebraska
Not yet recruiting -
Surgical Resection of Latent Brain Tumors Prior to Recurrence
Posted: March 23rd, 2021, 2:00pm GMT
Condition: Brain Neoplasm
Interventions: Procedure: Brain Surgery; Other: Quality-of-Life Assessment
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting -
Almonertinib as First-line Treatment in Patients With EGFR Mutations Positive in Advanced NSCLC With Brain Metastases
Posted: March 22nd, 2021, 2:00pm GMT
Condition: Lung Cancer
Intervention: Drug: Almonertinib
Sponsors: Zhejiang Cancer Hospital; Jiangsu Hansoh Pharmaceutical Co., Ltd.
Not yet recruiting -
Measuring Fatty Acid Oxidation in Cerebral Metastases Using [18F]FPIA
Posted: March 19th, 2021, 2:00pm GMT
Condition: Cerebral Metastases
Intervention: Other: PET/MRI
Sponsor: Imperial College London
Recruiting -
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability
Posted: March 18th, 2021, 2:00pm GMT
Conditions: Metastatic Lung Small Cell Carcinoma; Metastatic Malignant Neoplasm in the Brain; Recurrent Lung Small Cell Carcinoma; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
Interventions: Drug: Memantine Hydrochloride; Other: Neurocognitive Assessment; Radiation: Stereotactic Radiosurgery; Radiation: Whole-Brain Radiotherapy
Sponsors: NRG Oncology; National Cancer Institute (NCI)
Recruiting -
Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG)
Posted: March 18th, 2021, 2:00pm GMT
Conditions: Diffuse Intrinsic Pontine Glioma; Diffuse Pontine and Thalamic Gliomas; Diffuse Midline Glioma, H3 K27M-Mutant
Interventions: Drug: Panobinostat 15 MG; Device: Focused Ultrasound with neuro-navigator-controlled sonication
Sponsors: Columbia University; Focused Ultrasound Foundation
Recruiting -
A Neurocognitive Study in Patients With Brain Oligometastases Receiving Hypofractionated SRT
Posted: March 18th, 2021, 2:00pm GMT
Condition: Brain Metastases, Adult
Intervention: Radiation: Hypofractionated Stereotactic Radiotherapy
Sponsor: Chang Gung Memorial Hospital
Not yet recruiting -
Neurocognitive Outcome of Bilateral or Unilateral Hippocampal Avoidance WBRT With Memantine for Brain Metastases
Posted: March 17th, 2021, 2:00pm GMT
Condition: Metastatic Malignant Neoplasm to Brain
Interventions: Radiation: Conformal Whole Brain Radiotherapy with Unilateral Hippocampal Avoidance; Radiation: Conformal Whole Brain Radiotherapy with Bilateral Hippocampal Avoidance; Drug: Memantine Hydrochloride
Sponsor: National Taiwan University Hospital
Recruiting -
Immunotherapy With Autologous Tumor Lysate-Loaded Dendritic Cells In Patients With Newly Diagnosed Glioblastoma Multiforme
Posted: March 16th, 2021, 2:00pm GMT
Condition: Glioblastoma
Intervention: Biological: Dendritic Cells Vaccine
Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Recruiting -
The Child in Context Intervention Study
Posted: March 15th, 2021, 2:00pm GMT
Conditions: Rehabilitation; Brain Injuries; Brain Injury, Chronic; Brain Diseases; Family; Childhood Brain Tumor; Child Behavior; Parenting
Interventions: Other: Family centered in-home rehabilitation; Other: Control
Sponsors: Sunnaas Rehabilitation Hospital; The Research Council of Norway; Oslo University Hospital; Children's Hospital Medical Center, Cincinnati; Monash University; The Hospital of Vestfold
Recruiting -
ETMR One: An International Registry and Research Platform for Children With Embryonal Tumor With Multilayer Rosettes
Posted: March 12th, 2021, 3:00pm GMT
Condition: Embryonal Tumor With Multilayered Rosettes
Intervention:
Sponsor: Hackensack Meridian Health
Recruiting -
Using Information Technology to Improve Outcomes for Children Living With Cancer
Posted: March 10th, 2021, 3:00pm GMT
Condition: Cancer
Intervention: Behavioral: IP
Sponsors: Northwestern University; Ann & Robert H Lurie Children's Hospital of Chicago; National Cancer Institute (NCI)
Not yet recruiting -
PRophylactic Cerebral Irradiation or Active MAgnetic Resonance Imaging Surveillance in Small-cell Lung Cancer Patients (PRIMALung Study)
Posted: March 10th, 2021, 3:00pm GMT
Conditions: Limited Stage Small Cell Lung Cancer; Extensive-stage Small-cell Lung Cancer
Intervention: Radiation: Prophylactic cranial irradiation
Sponsors: European Organisation for Research and Treatment of Cancer - EORTC; UNICANCER
Not yet recruiting -
Multicenter Open Label Phase Ib/II Trial of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to HR+/Her2- Breast Cancer
Posted: March 10th, 2021, 3:00pm GMT
Condition: Breast Cancer
Interventions: Drug: Abemaciclib; Drug: Elacestrant
Sponsor: Criterium, Inc.
Not yet recruiting -
Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastases
Posted: March 9th, 2021, 3:00pm GMT
Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Clinical Stage IV Cutaneous Melanoma AJCC v8; Hematopoietic and Lymphoid Cell Neoplasm; Hormone Receptor Positive Breast Adenocarcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Solid Neoplasm; Metastatic Melanoma; Metastatic Triple-Negative Breast Carcinoma; Pathologic Stage IV Cutaneous Melanoma AJCC v8; Prognostic Stage IV Breast Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
Interventions: Drug: Bintrafusp Alfa; Drug: Pimasertib; Other: Quality-of-Life Assessment
Sponsor: M.D. Anderson Cancer Center
Recruiting -
Stereotactic Radiotherapy in Association With Immunotherapy for the Treatment of NSCLC Brain Metastases
Posted: March 8th, 2021, 3:00pm GMT
Condition: Brain Metastases From NSCLC
Intervention: Radiation: Valutation of toxicity
Sponsor: Azienda Ospedaliero-Universitaria Careggi
Recruiting -
Glutamate Excitotoxicity in Brain Metastases From Lung, Breast and Melanoma Treated With Stereotactic Radiosurgery
Posted: March 8th, 2021, 3:00pm GMT
Condition: Brain Metastases, Adult
Interventions: Radiation: Stereotactic radiosurgery; Diagnostic Test: Blood samples
Sponsor: IRCCS San Raffaele
Recruiting -
Infraorbital Nerve Block for Endoscopic Transsphenoidal Approach to Remove Pituitary Tumor
Posted: March 5th, 2021, 3:00pm GMT
Condition: Intraoperative Pain Control
Intervention: Drug: dexmedetomidine 5 mcg mixed with 0.5% plain bupivacaine
Sponsor: Chiang Mai University
Not yet recruiting -
Transnasal Endoscopic Pituitary Surgery - the Effect of Posterior Nasal Septum Resection on Nasal Functions
Posted: March 4th, 2021, 3:00pm GMT
Condition: Pituitary Adenoma
Intervention: Procedure: Posterium nasal septum resection
Sponsor: University Hospital Ostrava
Recruiting -
Loupe-Based Intraoperative Fluorescence Imaging
Posted: March 3rd, 2021, 3:00pm GMT
Conditions: Glioblastoma Multiforme; Anaplastic Astrocytoma
Intervention:
Sponsors: Guoqiang Yu; Bioptics Technology LLC; National Cancer Institute (NCI); Kentucky Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR)
Recruiting -
A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY)
Posted: March 3rd, 2021, 3:00pm GMT
Conditions: NSCLC; Brain Metastases; Leptomeningeal Metastasis
Interventions: Drug: almonertinib; Drug: LM-first line treatment; Drug: LM-second line treatment
Sponsor: Henan Cancer Hospital
Not yet recruiting -
Multimodality MRI and Liquid Biopsy in GBM
Posted: March 2nd, 2021, 3:00pm GMT
Conditions: Glioblastoma Multiforme; Brain Tumor, Adult: Glioblastoma; Brain Tumor, Recurrent; Brain Tumor, Primary
Intervention: Diagnostic Test: Post Feraheme Infusion MRI
Sponsor: University of Pennsylvania
Not yet recruiting -
Hyperpolarized 13C-pyruvate Metabolic MRI With Infiltrating Gliomas
Posted: February 26th, 2021, 3:00pm GMT
Condition: Glioma
Intervention: Drug: Hyperpolarized 13C-Pyruvate
Sponsor: University of Maryland, Baltimore
Recruiting -
Effect of Continous Intravenous Lidocaine Infusion Intraoperative for Craniotomy Tumor Removal Surgery
Posted: February 26th, 2021, 3:00pm GMT
Condition: Craniotomy Tumor Removal Surgery
Interventions: Drug: Continous Intravenous Lidocaine Infusion; Drug: Placebo
Sponsor: Indonesia University
Recruiting -
TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations
Posted: February 25th, 2021, 3:00pm GMT
Conditions: Advanced or Metastatic Solid Tumors Irrespective of Gene Alterations; Advanced or Metastatic Solid Tumors With Germline PTEN Inactivating Mutations
Intervention: Drug: TAS-117
Sponsor: Taiho Oncology, Inc.
Recruiting -
A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG)
Posted: February 25th, 2021, 3:00pm GMT
Conditions: Diffuse Intrinsic Pontine Glioma; Diffuse Midline Glioma, H3 K27M-Mutant
Interventions: Drug: BXQ-350 - Part 1 Dose Escalation: Safety and Tolerance; Drug: BXQ-350 - Part 2 BXQ-350 Tumor and Plasma Concentrations
Sponsors: Bexion Pharmaceuticals, Inc.; CTI Clinical Trial and Consulting Services
Recruiting -
MEP and Neuromuscular Blocker
Posted: February 24th, 2021, 3:00pm GMT
Condition: Brain Tumor
Intervention: Drug: Arm I (MEP)
Sponsor: Gangnam Severance Hospital
Recruiting -
Camrelizumab Combined With SRT/WBRT and Chemotherapy in Patients With Brain Metastases of Driven Gene-negative NSCLC
Posted: February 24th, 2021, 3:00pm GMT
Condition: Non-Small-Cell Lung Cancer
Interventions: Drug: Camrelizumab; Drug: Placebo; Drug: Cisplatin; Drug: Carboplatin; Drug: Pemetrexed; Drug: Paclitaxel; Drug: Albumin paclitaxel
Sponsor: Guangdong Association of Clinical Trials
Not yet recruiting -
A Single Arm Study of Brain Metastasis in Patients With HER2-positive Breast Cancer
Posted: February 23rd, 2021, 3:00pm GMT
Condition: TTP
Interventions: Drug: PYRROTINI; Radiation: Brain radiation therapy
Sponsor: Tianjin Medical University Cancer Institute and Hospital
Recruiting -
Contribution of Cerebral 18F-DOPA PET-CT Scan in High-grade Recurrent Gliomas
Posted: February 23rd, 2021, 3:00pm GMT
Condition: High Grade Glioma
Intervention: Device: Brain PET-CT of 18F-DOPA
Sponsor: Central Hospital, Nancy, France
Not yet recruiting -
Evaluation of Brain Changes in ALL Patients on Therapy
Posted: February 23rd, 2021, 3:00pm GMT
Condition: Acute Leukemia
Intervention: Diagnostic Test: MRI
Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Not yet recruiting -
Tamoxifen Versus Lomustine After First Recurrence in GBM Patients
Posted: February 22nd, 2021, 3:00pm GMT
Condition: Glioblastoma Multiforme
Interventions: Drug: Tamoxifen; Drug: Lomustine
Sponsor: AHS Cancer Control Alberta
Not yet recruiting -
A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme
Posted: February 19th, 2021, 3:00pm GMT
Condition: Glioblastoma Multiforme, Adult
Interventions: Drug: Berubicin; Drug: Lomustine
Sponsors: CNS Pharmaceuticals, Inc.; Worldwide Clinical Trials
Recruiting -
TKIs vs. Pertuzumab in HER2+ Breast Cancer Patients With Active Brain Metastases (HER2BRAIN)
Posted: February 18th, 2021, 3:00pm GMT
Conditions: HER2-positive Breast Cancer; Brain Metastases
Interventions: Drug: Trastuzumab; Drug: Taxanes; Drug: Pertuzumab; Drug: Tyrosine kinase inhibitor
Sponsors: Second Affiliated Hospital, School of Medicine, Zhejiang University; Peking University International Hospital; Sun Yat-sen University; Zhejiang University
Not yet recruiting -
Study on the Value of Non-invasive Dual-Pet Information in Type Subtype of Metastatic Breast Cancer
Posted: February 17th, 2021, 3:00pm GMT
Condition: Breast Cancer
Interventions: Procedure: biopsy or surgical pathology in metastases; Drug: 68Ga-HER2 affibody,18F-FDG, 18F-FES
Sponsor: Fudan University
Recruiting -
SGM-101 in Colorectal Brain Metastases.
Posted: February 16th, 2021, 3:00pm GMT
Conditions: Rectal Neoplasms; Rectum Cancer; Colorectal Neoplasms; Brain Metastases; Brain Neoplasms; Brain Diseases; Brain Cancer; Brain Tumor; Intestinal Neoplasms; Gastrointestinal Neoplasms; Gastrointestinal Cancer; Gastrointestinal Disease; Intestinal Disease
Intervention: Drug: SGM-101
Sponsors: Leiden University Medical Center; Medical Center Haaglanden; Surgimab
Not yet recruiting -
18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastases
Posted: February 12th, 2021, 3:00pm GMT
Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Clinical Stage IV Cutaneous Melanoma AJCC v8; Glioma; Malignant Brain Neoplasm; Metastatic Breast Carcinoma; Metastatic Colon Carcinoma; Metastatic Kidney Carcinoma; Metastatic Lung Carcinoma; Metastatic Malignant Neoplasm in the Brain; Metastatic Melanoma; Pathologic Stage IV Cutaneous Melanoma AJCC v8; Prognostic Stage IV Breast Cancer AJCC v8; Stage IV Colon Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v8; Stage IVA Colon Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Colon Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8; Stage IVC Colon Cancer AJCC v8
Interventions: Procedure: Computed Tomography; Drug: 18F-FMAU; Procedure: Multiparametric Magnetic Resonance Imaging; Procedure: Positron Emission Tomography
Sponsors: University of Southern California; National Cancer Institute (NCI)
Recruiting -
Phase II Study of T-DX in HER2-positive Breast Cancer Brain Metastases
Posted: February 12th, 2021, 3:00pm GMT
Condition: Breast Cancer Stage IV
Intervention: Drug: Trastuzumab deruxtecan
Sponsors: Medical University of Vienna; Daiichi Sankyo, Inc.
Recruiting -
Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma
Posted: February 11th, 2021, 3:00pm GMT
Condition: Diffuse Intrinsic Pontine Glioma
Intervention: Biological: Histone H3.3-K27M Neoantigen Vaccine Therapy
Sponsors: Yang Zhang; Guangdong TCRCure Biopharma Technology Co., Ltd; TCRCURE BIOPHARMA LTD.CHONGQING
Not yet recruiting -
A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas
Posted: February 9th, 2021, 3:00pm GMT
Conditions: Glioma; Glioma Intracranial; Gliomas Benign; Brain Tumor; Brain Cancer; Motor Cortex; Lesion
Intervention: Device: RNS System Implantation
Sponsor: Medical College of Wisconsin
Not yet recruiting -
Genomic Study in Non-small Cell Lung Cancer Brain Metastasis
Posted: February 9th, 2021, 3:00pm GMT
Conditions: NSCLC Stage IV; Brain Metastases
Intervention: Procedure: craniectomy
Sponsor: National Cheng-Kung University Hospital
Recruiting -
ONC206 for Treatment of Newly Diagnosed or Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant Brain Tumors (PNOC 023)
Posted: February 1st, 2021, 3:00pm GMT
Conditions: Diffuse Midline Glioma (DMG); Malignant Brain Tumors; Glioblastoma; Recurrent Ependymoma; Recurrent Malignant Brain Neoplasm; Spinal Cord Glioma; WHO Grade III Glioma
Interventions: Drug: ONC206; Radiation: Standard of Care Radiation Therapy
Sponsors: Sabine Mueller, MD, PhD; Chimerix; Mithil Prasad Foundation; Storm the Heavens Fund; The ChadTough Defeat DIPG Foundation
Not yet recruiting -
Metabolic Therapy Program In Conjunction With Standard Treatment For Glioblastoma Multiforme
Posted: January 29th, 2021, 3:00pm GMT
Condition: Glioblastoma Multiforme
Intervention: Other: Standard Treatment Plus Metabolic Therapy Program
Sponsor: Waikato Hospital
Recruiting -
Study of [68Ga]-FF58 in Patients With Selected Solid Tumors Expected to Overexpress αvβ3 and αvβ5 Integrins.
Posted: January 15th, 2021, 3:00pm GMT
Conditions: Glioblastoma Multiforme; Brain Neoplasms
Intervention: Drug: 68Ga-FF58
Sponsor: Novartis Pharmaceuticals
Not yet recruiting -
LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)
Posted: January 7th, 2021, 3:00pm GMT
Conditions: Glioma; Glioblastoma; Brain Tumor
Interventions: Procedure: LITT; Radiation: Hypofractionated Radiation Therapy
Sponsors: University of Maryland, Baltimore; Keep Punching Foundation
Recruiting -
Effectiveness of an Artificial Intelligent Tutoring System in Simulation Training
Posted: January 7th, 2021, 3:00pm GMT
Condition: Surgical Education
Interventions: Behavioral: Virtual Operative Assistant Training; Behavioral: Remote-Based Expert Instructor Training
Sponsor: McGill University
Recruiting -
Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study
Posted: December 30th, 2020, 3:00pm GMT
Condition: Recurrent Brain Metastases
Interventions: Procedure: Craniotomy; Radiation: Cesium-131 brachytherapy
Sponsors: Memorial Sloan Kettering Cancer Center; GT Medical Technologies, Inc.
Recruiting -
Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery
Posted: December 30th, 2020, 3:00pm GMT
Conditions: Brain Metastases, Adult; Brain Metastases; Brain Cancer
Intervention: Drug: 18F fluciclovine
Sponsors: Baptist Health South Florida; Blue Earth Diagnostics
Not yet recruiting -
A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
Posted: December 24th, 2020, 3:00pm GMT
Conditions: Central Nervous System Nongerminomatous Germ Cell Tumor; Choriocarcinoma; Embryonal Carcinoma; Immature Teratoma; Malignant Teratoma; Mixed Germ Cell Tumor; Pineal Region Germ Cell Tumor; Pineal Region Immature Teratoma; Pineal Region Yolk Sac Tumor; Suprasellar Germ Cell Tumor
Interventions: Drug: Carboplatin; Drug: Etoposide; Biological: Filgrastim; Drug: Ifosfamide; Drug: Mesna; Biological: Pegfilgrastim; Procedure: Peripheral Blood Stem Cell Transplantation; Other: Questionnaire Administration; Radiation: Radiation Therapy; Procedure: Second-Look Surgery; Drug: Thiotepa
Sponsor: Children's Oncology Group
Not yet recruiting -
Dexmedetomidine Alleviates Postoperative Delirium After Brain Tumor Resections
Posted: December 19th, 2020, 3:00pm GMT
Conditions: Dexmedetomidine; Postoperative Delirium
Interventions: Drug: Dexmedetomidine; Drug: 0.9% saline
Sponsor: Beijing Tiantan Hospital
Recruiting -
Study of Recombinant Human Endostatin Combined With CV Regimen in the Treatment of Pediatric Low-grade Gliomas
Posted: December 9th, 2020, 3:00pm GMT
Conditions: Low-grade Glioma; Pediatric Brain Tumor
Intervention: Drug: combined therapy with rh-ES and CV
Sponsor: Beijing Sanbo Brain Hospital
Recruiting -
Stereotactic Radiosurgery and Immunotherapy (Pembrolizumab) for the Treatment of Recurrent Meningioma
Posted: December 9th, 2020, 3:00pm GMT
Conditions: Grade I Meningioma, Adult; Grade II Meningioma, Adult; Grade III Meningioma, Adult; Recurrent Meningioma
Interventions: Drug: Pembrolizumab; Procedure: Stereotactic Radiosurgery
Sponsors: Nancy Ann Oberheim Bush, MD; Merck Sharp & Dohme Corp.
Recruiting -
Brigatinib Before Brain Irradiation Trial (B3i Trial)
Posted: November 18th, 2020, 3:00pm GMT
Conditions: Brain Metastases; Lung Cancer
Intervention: Drug: Brigatinib
Sponsors: University of Colorado, Denver; National Cancer Institute (NCI)
Recruiting -
Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread
Posted: November 17th, 2020, 3:00pm GMT
Conditions: Extensive Stage Lung Small Cell Carcinoma; Malignant Solid Neoplasm; Metastatic Malignant Neoplasm in the Brain
Interventions: Biological: Atezolizumab; Drug: Carboplatin; Drug: Entinostat; Drug: Etoposide
Sponsor: National Cancer Institute (NCI)
Recruiting -
Study of Pamiparib in Newly Diagnosed and rGBM
Posted: November 4th, 2020, 3:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme; Glioblastoma Multiforme, Adult
Interventions: Drug: Pamiparib; Drug: Olaparib; Radiation: Radiation therapy; Drug: Temozolomide
Sponsors: Nader Sanai; Barrow Neurological Institute; Ivy Brain Tumor Center; BeiGene
Recruiting -
Postoperative Risk Prediction Score After Elective Intracranial Neurosurgery Operation
Posted: October 14th, 2020, 2:00pm GMT
Conditions: Brain Tumor; Post-Op Complication; Anesthesia
Interventions: Other: Quality of Recovery-15; Other: Glasgow Result Scale; Other: Risk Factors
Sponsor: Trakya University
Not yet recruiting