Condition: Recurrent Glioblastoma
Intervention: Drug: Personalized drug combination
Sponsors: Oslo University Hospital; Institute for Molecular Medicine
Recruiting
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6810 items (6810 unread) in 74 feeds
Acinar Cell Carcinoma
(81 unread)
Acinic Cell Carcinoma
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Adenoid Cystic Carcinoma
(159 unread)
Adrenal Gland Cancer
(533 unread)
Ampulla Of Vater
(68 unread)
Anal Cancer
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Angiosarcoma
(153 unread)
Appendix Cancer
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Bile Duct Cancer
(845 unread)
Brain and CNS
(878 unread)
Carcinoid
(266 unread)
Endocrine/Neuroendocrine
(808 unread)
Gall Bladder Cancer
(381 unread)
Hemangioendothelioma
(215 unread)
Hepatoblastoma
(129 unread)
Pancreas
(117 unread)
Phyllodes
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PMP and Mucinous Tumors
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Rhabdomyosarcoma
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Sarcoma
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Trial - Brain Tumor (100 unread)
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Individualized Systems Medicine Functional Profiling for Recurrent Glioblastoma
Posted: September 14th, 2021, 2:00pm GMT
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Treatment With Tucatinib in Patients With an Isolated Brain Progression of a Metastatic Breast Cancer
Posted: September 13th, 2021, 2:00pm GMT
Condition: Metastatic Breast Cancer With a Isolated Brain Progression
Interventions: Drug: Tucatinib; Drug: Pertuzumab; Drug: Trastuzumab; Drug: Hormone therapy
Sponsors: UNICANCER; Seagen Inc.; ARCAGY/ GINECO GROUP
Not yet recruiting -
A Study of Pyrotinib Plus Capecitabine Combined With SRT in HER2+ MBC With Brain Metastases
Posted: September 13th, 2021, 2:00pm GMT
Condition: HER2-positive Metastatic Breast Cancer
Intervention: Combination Product: radiation combined with pyrotinib and capecitabine
Sponsor: Jiangxi Provincial Cancer Hospital
Not yet recruiting -
A Study to Evaluate the Efficacy of Osimertinib With Early Intervention SRS Treatment Compared to the Continuation of Osimertinib Alone, in Patients With EGFR Mutated NSCLC and Asymptomatic Brain Metastases
Posted: September 3rd, 2021, 2:00pm GMT
Conditions: NSCLC; EGFR Gene Mutation; EGF-R Positive Non-Small Cell Lung Cancer; Non-small Cell Lung Cancer; Brain Metastases
Intervention: Radiation: Stereotactic surgery
Sponsor: Hadassah Medical Organization
Recruiting -
Tolerability and Activity of Brivaracetam (BRV) in Patients With Diffuse Gliomas
Posted: September 1st, 2021, 2:00pm GMT
Condition: Brain Tumor
Intervention: Drug: Brivaracetam
Sponsor: University of Rochester
Not yet recruiting -
Preoperative Radiosurgery for the Treatment of High Grade Glioma, The NeoGlioma Study
Posted: September 1st, 2021, 2:00pm GMT
Condition: Malignant Glioma
Interventions: Radiation: Radiation Therapy; Radiation: Radiosurgery; Procedure: Stereotactic Biopsy; Drug: Temozolomide; Procedure: Therapeutic Conventional Surgery; Procedure: Tumor Treating Fields Therapy
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Not yet recruiting -
Evaluation of the Incidence of NTRK Gene Fusion in Adult Brain Tumours
Posted: August 30th, 2021, 2:00pm GMT
Condition: Glioma
Interventions: Other: Glioma data collection; Other: Brain metastasis data collection
Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche
Not yet recruiting -
Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases
Posted: August 27th, 2021, 2:00pm GMT
Conditions: Neoplasm Metastasis; Spinal Cord Diseases; Spinal Cord Compression; Spinal Cord Tumor; Spine Metastases
Interventions: Procedure: Stereotactic Laser Ablation; Radiation: Stereotactic Radiosurgery; Diagnostic Test: MRI guided laser ablation
Sponsors: Henry Ford Health System; Medtronic
Recruiting -
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors
Posted: August 26th, 2021, 2:00pm GMT
Conditions: Brain Tumor; Brain Cancer; Motor Cortex; Lesion
Intervention: Procedure: Intraoperative Brain Simulation - Alternate Stimulation Parameters
Sponsor: Medical College of Wisconsin
Not yet recruiting -
Study of DSP-0390 in Patients With Recurrent High-Grade Glioma
Posted: August 26th, 2021, 2:00pm GMT
Conditions: High Grade Glioma; Glioblastoma Multiforme
Intervention: Drug: DSP-0390
Sponsor: Sumitomo Dainippon Pharma Oncology, Inc
Not yet recruiting -
Pilot Study to Enable Electronic Laboratory Data Transfer From Participating Institutions to MediData/RAVE
Posted: August 25th, 2021, 2:00pm GMT
Condition: Accurate and Complete Data Acquisition for Clinical Trials
Intervention: Other: Medidata RAVE
Sponsors: Children's Oncology Group; National Cancer Institute (NCI); Pediatric Brain Tumor Consortium
Recruiting -
Toripalimab Combined With Anlotinib and SBRT in Patients With Untreated Brain Metastases of Driven Gene-negative NSCLC
Posted: August 25th, 2021, 2:00pm GMT
Condition: NSCLC
Interventions: Drug: Toripalimab; Drug: Anlotinib; Drug: SBRT 7Gy✖️5 QD
Sponsor: Hubei Cancer Hospital
Not yet recruiting -
fMRI Study of Functional Reorganization in Glioma Patients
Posted: August 24th, 2021, 2:00pm GMT
Condition: Glioma
Intervention: Device: GE 3.0T MRI
Sponsor: First Affiliated Hospital Xi'an Jiaotong University
Not yet recruiting -
ARX788 in HER2-positive Breast Cancer Patients With Brain Metastases
Posted: August 24th, 2021, 2:00pm GMT
Condition: HER2-positive, Metastatic Breast Cancer
Intervention: Drug: ARX788
Sponsor: Fudan University
Recruiting -
Brain-Shift Monitoring Using 3D Scanning
Posted: August 24th, 2021, 2:00pm GMT
Condition: Craniotomy for Epilepsy and Malignant Tumor Removal
Intervention: Device: Brain shift monitoring
Sponsor: Advanced Scanners Inc.
Recruiting -
Physical Training in Glioblastoma Patients During Cytotoxic Therapy
Posted: August 20th, 2021, 2:00pm GMT
Condition: Glioblastoma
Intervention: Other: Personal Training Program
Sponsor: University Hospital Muenster
Recruiting -
The Neural Coding of Speech Across Human Languages
Posted: August 20th, 2021, 2:00pm GMT
Conditions: Epilepsy; Brain Tumor; Speech; Bilingualism
Intervention: Behavioral: Speech Tasks
Sponsors: University of California, San Francisco; University of California, Berkeley; Lawrence Livermore National Laboratory; The University of Hong Kong; National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting -
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
Posted: August 20th, 2021, 2:00pm GMT
Conditions: Neoplasm, Colorectal; Cognitive Impairment; Cognitive Dysfunction; Cognitive Change; Chemo-brain; Chemo Fog; Chemotherapy Effect; Cognitive Decline
Intervention:
Sponsors: Joseph McCollom; Indiana University School of Medicine
Not yet recruiting -
NTS-WBRT VS HA-WBRT in Brain Metastases
Posted: August 19th, 2021, 2:00pm GMT
Condition: Brain Metastases
Interventions: Radiation: NTS-WBRT (normal tissue sparing whole brain radiation therapy); Radiation: HA-WBRT (hippocampal avoidance whole brain radiation therapy); Drug: Memantine
Sponsor: Massachusetts General Hospital
Not yet recruiting -
Study of Nivolumab and Ipilimumab Plus Chemotherapy as a Treatment for Patients With Stage IV Lung Cancer With Brain Metastases
Posted: August 19th, 2021, 2:00pm GMT
Conditions: Non Small Cell Lung Cancer; Brain Metastases, Adult; Lung Cancer
Interventions: Drug: Ipilimumab; Drug: Nivolumab; Drug: Carboplatin; Drug: Cisplatin; Drug: Paclitaxel; Drug: Pemetrexed
Sponsor: Fundación GECP
Not yet recruiting -
Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies
Posted: August 18th, 2021, 2:00pm GMT
Conditions: Central Nervous System Lymphoma; Hematopoietic and Lymphoid Cell Neoplasm; Leukemia; Lymphoma; Plasma Cell Myeloma; Secondary Central Nervous System Lymphoma
Interventions: Procedure: Magnetic Resonance Imaging; Other: Neurocognitive Assessment; Other: Quality-of-Life Assessment; Other: Questionnaire Administration
Sponsor: M.D. Anderson Cancer Center
Recruiting -
EffectsOfTranscranialPulseStimulationOnDepression-PilotRCT
Posted: August 16th, 2021, 2:00pm GMT
Condition: Major Depressive Disorder
Intervention: Device: Transcranial Pulse Stimulation
Sponsor: The Hong Kong Polytechnic University
Recruiting -
Effect of Dexmedetomidine on Quality of Recovery in Non-functioning Pituitary Adenoma Patients Undergoing Endoscopic Transsphenoidal Surgery
Posted: August 13th, 2021, 2:00pm GMT
Condition: Non-functioning Pituitary Adenoma
Interventions: Drug: Dexmedetomidine; Drug: normal saline
Sponsor: Seoul National University Hospital
Not yet recruiting -
Intra-Arterial Chemotherapy for Newly Diagnosed, Residual, or Recurrent Atypical Choroid Plexus Papilloma and Choroid Plexus Carcinoma Prior to Second-Look Surgery
Posted: August 6th, 2021, 2:00pm GMT
Conditions: Atypical Choroid Plexus Papilloma; Choroid Plexus Carcinoma
Interventions: Drug: Melphalan; Drug: Carboplatin; Drug: Topotecan
Sponsors: Weill Medical College of Cornell University; Columbia University
Not yet recruiting -
Niraparib in Tumors Metastatic to the CNS
Posted: August 5th, 2021, 2:00pm GMT
Conditions: Metastatic Cancer; Central Nervous System Cancer
Intervention: Drug: Niraparib
Sponsors: Massachusetts General Hospital; GlaxoSmithKline
Not yet recruiting -
Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology
Posted: August 3rd, 2021, 2:00pm GMT
Conditions: Central Nervous System Neoplasm; Leptomeningeal Neoplasm; Metastatic Malignant Neoplasm in the Brain; Primary Brain Neoplasm
Interventions: Other: Electronic Health Record Review; Other: Survey Administration
Sponsor: M.D. Anderson Cancer Center
Recruiting -
6 Months Adjuvant Temozolomide (TMZ) vs No Adjuvant TMZ in Newly Diagnosed MGMT Methylated Glioblastoma (GBM)
Posted: June 15th, 2021, 2:00pm GMT
Condition: MGMT-Methylated Glioblastoma
Interventions: Other: Delay of TMZ; Other: Standard of Care (SOC) Adjuvant TMZ (no intervention
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Not yet recruiting -
HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma
Posted: May 26th, 2021, 2:00pm GMT
Condition: Ependymoma
Intervention: Biological: HER2 Specific CAR T Cell
Sponsors: Pediatric Brain Tumor Consortium; Texas Children's Cancer Center; Baylor College of Medicine
Not yet recruiting -
Neuro-pharmacological Study of Ketoconazole for High-grade Gliomas
Posted: May 3rd, 2021, 2:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme; Glioblastoma Multiforme of Brain; Glioblastoma Multiforme, Adult
Intervention: Drug: Ketoconazole
Sponsor: Milton S. Hershey Medical Center
Not yet recruiting -
Tranexamic Acid for Blood Loss Minimization in Endoscopic Pituitary Surgery
Posted: April 28th, 2021, 2:00pm GMT
Conditions: Pituitary Tumor; Blood Loss; Surgery
Interventions: Drug: Tranexamic acid; Drug: Placebo
Sponsor: University of North Carolina, Chapel Hill
Recruiting -
Neuro-pharmacological Study of Posaconazole for High-grade Gliomas: A Phase 0 Clinical Trial
Posted: April 1st, 2021, 2:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme; Glioblastoma Multiforme of Brain; Glioblastoma Multiforme, Adult
Intervention: Drug: Posaconazole Pill
Sponsor: Milton S. Hershey Medical Center
Not yet recruiting -
The Child in Context Intervention Study
Posted: March 15th, 2021, 2:00pm GMT
Conditions: Rehabilitation; Brain Injuries; Brain Injury, Chronic; Brain Diseases; Family; Childhood Brain Tumor; Child Behavior; Parenting
Interventions: Other: Family centered in-home rehabilitation; Other: Control
Sponsors: Sunnaas Rehabilitation Hospital; The Research Council of Norway; Oslo University Hospital; Children's Hospital Medical Center, Cincinnati; Monash University; The Hospital of Vestfold
Recruiting -
A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY)
Posted: March 3rd, 2021, 3:00pm GMT
Conditions: NSCLC; Brain Metastases; Leptomeningeal Metastasis
Interventions: Drug: almonertinib; Drug: LM-first line treatment; Drug: LM-second line treatment
Sponsor: Henan Cancer Hospital
Recruiting -
Contribution of Cerebral 18F-DOPA PET-CT Scan in High-grade Recurrent Gliomas
Posted: February 23rd, 2021, 3:00pm GMT
Condition: High Grade Glioma
Intervention: Device: Brain PET-CT of 18F-DOPA
Sponsor: Central Hospital, Nancy, France
Recruiting -
A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer
Posted: February 5th, 2021, 3:00pm GMT
Condition: Breast Cancer
Intervention: Drug: Trastuzumab Deruxtecan
Sponsors: AstraZeneca; Daiichi Sankyo, Inc.
Recruiting -
Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread
Posted: November 17th, 2020, 3:00pm GMT
Conditions: Extensive Stage Lung Small Cell Carcinoma; Malignant Solid Neoplasm; Metastatic Malignant Neoplasm in the Brain
Interventions: Biological: Atezolizumab; Drug: Carboplatin; Drug: Entinostat; Drug: Etoposide
Sponsor: National Cancer Institute (NCI)
Recruiting -
A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease
Posted: November 6th, 2020, 3:00pm GMT
Conditions: Alzheimer Disease; Cognitive Dysfunction; Dementia
Interventions: Drug: JNJ-63733657; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Recruiting -
Chemotherapy and Atezolizumab for Patients With Extensive Stage Small Cell Lung Cancer (SCLC) With Untreated, Asymptomatic Brain Metastases
Posted: October 30th, 2020, 2:00pm GMT
Conditions: Small-cell Lung Cancer; Brain Metastases
Interventions: Drug: Carboplatin; Drug: Etoposide; Drug: Atezolizumab
Sponsors: Jeffrey Clarke; Genentech, Inc.; Duke University
Recruiting -
A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma
Posted: October 6th, 2020, 2:00pm GMT
Conditions: Recurrent Low Grade Astrocytoma; Recurrent WHO Grade II Glioma; Refractory Low Grade Astrocytoma; Refractory Low Grade Glioma; Refractory WHO Grade I Glioma
Interventions: Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Selumetinib Sulfate; Drug: Vinblastine Sulfate
Sponsor: National Cancer Institute (NCI)
Recruiting -
Corticotrophin-releasing Hormone (CRH) Stimulation for 18F-FDG-PET Detection of Pituitary Adenoma in Cushing s Disease
Posted: September 30th, 2020, 2:00pm GMT
Conditions: Cushing's Disease; Pituitary Adenoma
Intervention: Drug: Acthrel
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting -
LUMINOS-101: PVSRIPO and Pembrolizumab in Patients With Recurrent Glioblastoma
Posted: July 21st, 2020, 2:00pm GMT
Conditions: Glioblastoma; Recurrent Glioblastoma; Supratentorial Glioblastoma; Brain Tumor
Interventions: Biological: PVSRIPO; Biological: pembrolizumab
Sponsor: Istari Oncology, Inc.
Recruiting -
Study to Establish the Diagnostic Performance of 18F Fluciclovine PET in Detecting Recurrent Brain Metastases
Posted: June 1st, 2020, 2:00pm GMT
Condition: Brain Metastases
Intervention: Drug: 18F fluciclovine
Sponsors: Blue Earth Diagnostics; Precision For Medicine
Recruiting -
Study to Establish Image Interpretation Criteria for 18F Fluciclovine PET in Detecting Recurrent Brain Metastases (PURSUE)
Posted: June 1st, 2020, 2:00pm GMT
Condition: Brain Metastases
Intervention: Drug: 18F fluciclovine
Sponsors: Blue Earth Diagnostics; Precision For Medicine
Recruiting -
Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma
Posted: May 21st, 2020, 2:00pm GMT
Conditions: Gliosarcoma; MGMT-Unmethylated Glioblastoma
Interventions: Biological: Ipilimumab; Biological: Nivolumab; Device: NovoTTF-100A Device; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Radiation: Radiation Therapy; Drug: Temozolomide
Sponsors: National Cancer Institute (NCI); NRG Oncology
Recruiting -
Safety Study of Pritumumab in Brain Cancer
Posted: May 21st, 2020, 2:00pm GMT
Conditions: Malignant Primary Brain Tumors; Brain Metastases, Adult
Intervention: Biological: Pritumumab
Sponsors: Nascent Biotech; Hoag Memorial Hospital Presbyterian
Recruiting -
Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing s Disease
Posted: April 9th, 2020, 2:00pm GMT
Condition: Cushing's Disease
Intervention: Drug: Vorinostat
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting -
National Cancer Institute "Cancer Moonshot Biobank"
Posted: March 19th, 2020, 2:00pm GMT
Conditions: Castration-Resistant Prostate Carcinoma; Clinical Stage III Cutaneous Melanoma AJCC v8; Clinical Stage IV Cutaneous Melanoma AJCC v8; Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8; Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8; Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8; Hematopoietic and Lymphoid Cell Neoplasm; Lung Non-Small Cell Carcinoma; Lung Small Cell Carcinoma; Malignant Solid Neoplasm; Pathologic Stage III Cutaneous Melanoma AJCC v8; Pathologic Stage IIIA Cutaneous Melanoma AJCC v8; Pathologic Stage IIIB Cutaneous Melanoma AJCC v8; Pathologic Stage IIIC Cutaneous Melanoma AJCC v8; Pathologic Stage IIID Cutaneous Melanoma AJCC v8; Pathologic Stage IV Cutaneous Melanoma AJCC v8; Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8; Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8; Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8; Refractory Plasma Cell Myeloma; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8; Stage IVB Colorectal Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8; Stage IVB Prostate Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8
Interventions: Procedure: Biospecimen Collection; Other: Medical Chart Review
Sponsor: National Cancer Institute (NCI)
Recruiting -
Camrelizumab Combined With Local Treatment in NSCLC Patients With BM
Posted: March 2nd, 2020, 3:00pm GMT
Conditions: NSCLC Stage IV; Brain Metastases; Immunotherapy
Interventions: Drug: Immunotherapy; Radiation: WBRT; Drug: Chemotherapy
Sponsor: Zhejiang Cancer Hospital
Recruiting -
HA-WBRT vs SRS in Patients With Multiple Brain Metastases
Posted: February 20th, 2020, 3:00pm GMT
Condition: Brain Metastases
Interventions: Radiation: Hippocampal Avoiding Whole Brain Radiation Therapy with Simultaneous Integrated Boost; Radiation: Single session or hypofractionated stereotactic radiosurgery
Sponsor: Medical University Innsbruck
Recruiting -
The Brain Metabolic Change in Chronic Cancer Pain Patient: FDG PET Image Study
Posted: February 5th, 2020, 3:00pm GMT
Condition: Cancer Pain
Intervention: Diagnostic Test: FDG PET
Sponsor: National Taiwan University Hospital
Recruiting -
A Study of Abemaciclib (LY2835219) in Combination With Temozolomide and Irinotecan and Abemaciclib in Combination With Temozolomide in Children and Young Adult Participants With Solid Tumors
Posted: January 23rd, 2020, 3:00pm GMT
Conditions: Relapsed Solid Tumor; Refractory Solid Tumor
Interventions: Drug: Abemaciclib; Drug: Irinotecan; Drug: Temozolomide
Sponsor: Eli Lilly and Company
Recruiting -
Detection of PitNET Tissue During TSS Using Bevacizumab-800CW
Posted: December 30th, 2019, 3:00pm GMT
Conditions: Pituitary Tumor; Pituitary Adenoma; Pituitary Macroadenoma
Interventions: Drug: Bevacizumab-IRDye800CW; Device: Molecular Fluorescence Endoscopy platform
Sponsor: University Medical Center Groningen
Recruiting -
Recovery After Cerebral Hemorrhage
Posted: December 6th, 2019, 3:00pm GMT
Conditions: Intra Cerebral Hemorrhage; Subarachnoid Hemorrhage; Intraventricular Hemorrhage; Nontraumatic Haemorrhage
Intervention:
Sponsor: University of Maryland, Baltimore
Recruiting -
A Clinical Trial Evaluating the Efficacy of Valganciclovir in Glioblastoma Patients
Posted: October 4th, 2019, 2:00pm GMT
Condition: Glioblastoma Multiforme
Interventions: Drug: Valganciclovir Tablets; Drug: Temozolomide 120 mg; Radiation: Radiotherapy 60 Gy; Drug: Placebo oral tablet
Sponsors: Cecilia Soderberg-Naucler; Karolinska University Hospital; Karolinska Institutet
Recruiting -
Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease
Posted: October 3rd, 2019, 2:00pm GMT
Condition: Metastatic Malignant Neoplasm in the Brain
Interventions: Radiation: Single Fraction Stereotactic Radiosurgery; Radiation: Fractionated Stereotactic Radiosurgery; Procedure: Quality-of-Life Assessment; Other: Questionnaire Administration
Sponsors: Alliance for Clinical Trials in Oncology; National Cancer Institute (NCI)
Recruiting -
Fluoroethyltyrosine in Detecting Tumors in Participants With Recurrent Intracranial Tumors
Posted: August 5th, 2019, 2:00pm GMT
Conditions: Intracranial Neoplasm; Low Grade Glioma; Recurrent Glioblastoma; Recurrent World Health Organization (WHO) Grade II Glioma; Recurrent WHO Grade III Glioma
Interventions: Drug: F-18 Fluoroethyltyrosine (FET); Procedure: Positron Emission Tomography (PET)
Sponsor: Thomas Hope
Recruiting -
Body Image and Self-esteem in Adolescence
Posted: August 2nd, 2019, 2:00pm GMT
Condition: Body Image
Interventions: Other: Body Image evaluation; Other: Self esteem evaluation
Sponsor: Meyer Children's Hospital
Recruiting -
Genetic Testing in Guiding Treatment for Patients With Brain Metastases
Posted: June 21st, 2019, 2:00pm GMT
Conditions: CDK Gene Mutation; Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Solid Neoplasm; NTRK Family Gene Mutation; PI3K Gene Mutation; ROS1 Gene Mutation
Interventions: Drug: Abemaciclib; Drug: PI3K Inhibitor paxalisib; Drug: Entrectinib
Sponsors: Alliance for Clinical Trials in Oncology; National Cancer Institute (NCI); Genentech, Inc.
Recruiting -
Epidemiology of Pituitary Tumours: Prevalence of Associated Neoplasia
Posted: June 4th, 2019, 2:00pm GMT
Conditions: Pituitary Tumor; Endocrine Neoplasia; Hyperparathyroidism; Solid Tumor; Familial Tumor Syndrome
Intervention: Other: Registration of familial forms and associated neoplasia
Sponsor: Neuromed IRCCS
Recruiting -
Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas
Posted: June 3rd, 2019, 2:00pm GMT
Conditions: High Grade Glioma; Anaplastic Astrocytoma; Anaplastic Oligodendroglioma; Glioblastoma
Interventions: Drug: Regadenoson 0.05mg; Drug: Regadensoson 0.1mg; Drug: Regadensoson 0.2mg; Drug: Regadensoson 0.4mg; Drug: Regadensoson 0.7mg; Drug: Regadensoson 1.0mg; Drug: Regadensoson 1.4mg
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; National Cancer Institute (NCI)
Recruiting -
AXL Inhibitor BGB324 in Treating Participants With Recurrent Glioblastoma Undergoing Surgery
Posted: May 29th, 2019, 2:00pm GMT
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: BGB 324 (before surgery); Drug: BGB 324 (after surgery)
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; National Cancer Institute (NCI); BerGenBio ASA
Recruiting -
MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas
Posted: May 24th, 2019, 2:00pm GMT
Conditions: Plexiform Neurofibroma; Neurofibromatosis Type 1 (NF1)
Intervention: Drug: Mirdametinib (PD-0325901) oral capsule or dispersible tablet
Sponsor: SpringWorks Therapeutics, Inc.
Recruiting -
Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy
Posted: May 16th, 2019, 2:00pm GMT
Conditions: Glioma; Gliomas; High Grade Glioma; Malignant Glioma; Low Grade Glioma
Intervention: Device: 3T MRI scanner
Sponsor: National Cancer Institute (NCI)
Recruiting -
BGB-290 and Temozolomide in Treating Patients With Recurrent Gliomas With IDH1/2 Mutations
Posted: April 16th, 2019, 2:00pm GMT
Conditions: IDH1 Mutation; IDH2 Mutation; Recurrent Glioblastoma; Recurrent WHO Grade II Glioma; Recurrent WHO Grade III Glioma
Interventions: Drug: PARP Inhibitor BGB-290; Drug: Temozolomide; Procedure: Therapeutic Conventional Surgery
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; National Cancer Institute (NCI); BeiGene
Recruiting -
A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma
Posted: March 12th, 2019, 2:00pm GMT
Conditions: Low Grade Glioma; Neurofibromatosis Type 1; Visual Pathway Glioma
Interventions: Drug: Carboplatin; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Selumetinib Sulfate; Drug: Vincristine Sulfate
Sponsor: National Cancer Institute (NCI)
Recruiting -
Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors
Posted: November 21st, 2018, 3:00pm GMT
Conditions: Malignant Solid Neoplasm; Metastatic Malignant Neoplasm in the Brain
Interventions: Procedure: Conventional Surgery; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Radiation: Stereotactic Radiosurgery
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting -
Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases
Posted: September 21st, 2018, 2:00pm GMT
Conditions: Invasive Malignant Neoplasm; Metastatic Malignant Neoplasm in the Brain
Interventions: Procedure: Dynamic Susceptibility Contrast-MRI (DSC-MRI); Procedure: Magnetic Resonance Imaging (MRI)
Sponsor: Emory University
Recruiting -
Nasal Packing Following Endoscopic Endonasal Pituitary Resection
Posted: September 19th, 2018, 2:00pm GMT
Condition: Pituitary Tumor
Interventions: Procedure: No nasal packing.; Procedure: Nasal Packing
Sponsors: Ottawa Hospital Research Institute; The Physicians' Services Incorporated Foundation
Recruiting -
ANG1005 in Leptomeningeal Disease From Breast Cancer
Posted: August 3rd, 2018, 2:00pm GMT
Conditions: Leptomeningeal Carcinomatosis; Leptomeningeal Metastases; Brain Metastases; HER2-negative Breast Cancer
Interventions: Drug: ANG1005; Drug: Physician's Best Choice
Sponsor: Angiochem Inc
Not yet recruiting -
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
Posted: July 30th, 2018, 2:00pm GMT
Conditions: High Grade Glioma; Diffuse Intrinsic Pontine Glioma
Interventions: Drug: PTC596; Radiation: Radiotherapy
Sponsors: Nationwide Children's Hospital; PTC Therapeutics
Recruiting -
Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors
Posted: July 26th, 2018, 2:00pm GMT
Conditions: Recurrent Diffuse Intrinsic Pontine Glioma; Recurrent Malignant Glioma; Recurrent Medulloblastoma; Recurrent Primary Central Nervous System Neoplasm; Refractory Diffuse Intrinsic Pontine Glioma; Refractory Malignant Glioma; Refractory Medulloblastoma; Refractory Primary Central Nervous System Neoplasm
Intervention: Drug: Savolitinib
Sponsor: National Cancer Institute (NCI)
Recruiting -
A Biospecimen Collection Study in BRAF-V600E Mutated Recurrent Gliomas
Posted: July 20th, 2018, 2:00pm GMT
Conditions: Glioma; BRAF V600E; Pleomorphic Xantho-Astrocytoma; Glioblastoma
Intervention: Procedure: Surgical Cohort
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Musella Foundation
Recruiting -
PreOperative Brain Irradiation in Glioblastoma
Posted: July 11th, 2018, 2:00pm GMT
Condition: Glioblastoma Multiforme
Intervention: Radiation: Preoperative brain irradiation (single fraction)
Sponsors: The Christie NHS Foundation Trust; Liverpool Clinical Trials Centre; The Netherlands Cancer Institute; Salford Royal NHS Foundation Trust; University of Manchester
Not yet recruiting -
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5-15 Brain Metastases
Posted: June 8th, 2018, 2:00pm GMT
Condition: Brain Metastases
Interventions: Drug: Memantine; Radiation: Hippocampal-avoidant (HA-WBRT) Radiotherapy; Procedure: Stereotactic Radiosurgery (SRS)
Sponsors: Canadian Cancer Trials Group; Alliance for Clinical Trials in Oncology; NRG Oncology
Recruiting -
[18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers
Posted: May 29th, 2018, 2:00pm GMT
Conditions: Healthy Subject; Intracranial Neoplasm; Glioblastoma
Interventions: Drug: Fluorine F 18 DASA-23; Procedure: Positron Emission Tomography
Sponsor: Guido A. Davidzon, MD, SM
Recruiting -
CB-839 With Radiation Therapy and Temozolomide in Treating Patients With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma
Posted: May 18th, 2018, 2:00pm GMT
Conditions: Anaplastic Astrocytoma, IDH-Mutant; Diffuse Astrocytoma, IDH-Mutant
Interventions: Other: Questionnaire Administration; Radiation: Radiation Therapy; Drug: Telaglenastat Hydrochloride; Drug: Temozolomide
Sponsor: National Cancer Institute (NCI)
Recruiting -
Adolescent and Young Adult Cancer Patients: Cognitive Toxicity on Survivorship (ACTS)
Posted: March 23rd, 2018, 2:00pm GMT
Conditions: Breast Cancer; Lymphoma; Germ Cell Tumor; Cognitive Impairment
Intervention:
Sponsor: National University, Singapore
Recruiting -
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
Posted: February 6th, 2018, 3:00pm GMT
Conditions: Recurrent Glioblastoma Multiforme; Primary Glioblastoma Multiforme; Brain Neoplasms, Malignant; Leptomeningeal Disease (LMD)
Interventions: Radiation: Radiation Therapy; Drug: AZD1390
Sponsor: AstraZeneca
Recruiting -
Effects of Intraoperative GDFT on the Postoperative Brain Edema
Posted: October 27th, 2017, 2:00pm GMT
Conditions: Fluid Therapy; Brain Edema; Brain Tumor
Interventions: Other: SVV-based GDFT; Other: traditional fluid therapy
Sponsor: Beijing Tiantan Hospital
Recruiting -
Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM
Posted: July 11th, 2017, 2:00pm GMT
Conditions: Glioblastoma Multiforme (GBM); Glioblastoma; Glioma of Brain; Glioblastoma, Adult; Brain Tumor; Brain Tumor, Primary; Brain Tumor Adult; Cancer; Brain Cancer
Interventions: Drug: Capecitabine; Drug: Temozolomide
Sponsor: Northwell Health
Recruiting -
Testing the Drug Atezolizumab or Placebo With Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer
Posted: June 27th, 2017, 2:00pm GMT
Conditions: Breast Adenocarcinoma; Metastatic Breast Adenocarcinoma; Recurrent Breast Carcinoma; Stage III Breast Cancer AJCC v7; Stage IIIA Breast Cancer AJCC v7; Stage IIIB Breast Cancer AJCC v7; Stage IIIC Breast Cancer AJCC v7; Stage IV Breast Cancer AJCC v6 and v7; Unresectable Breast Carcinoma
Interventions: Drug: Atezolizumab; Drug: Docetaxel; Drug: Paclitaxel; Biological: Pertuzumab; Other: Placebo Administration; Other: Quality-of-Life Assessment; Biological: Trastuzumab
Sponsors: National Cancer Institute (NCI); NRG Oncology
Recruiting -
Assessment of Neurocognitive Function in Patients With Multiple Brain Metastases Undergoing Stereotactic Radiosurgery or Stereotactic Body Radiation Therapy
Posted: June 12th, 2017, 2:00pm GMT
Conditions: Metastatic Malignant Neoplasm in the Brain; Solid Neoplasm
Interventions: Procedure: Cognitive Assessment; Radiation: Stereotactic Radiosurgery; Radiation: Stereotactic Body Radiation Therapy
Sponsor: Sidney Kimmel Cancer Center at Thomas Jefferson University
Recruiting -
Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers
Posted: June 2nd, 2017, 2:00pm GMT
Conditions: Medulloblastoma; Ependymoma; Pineal RegionTumors; Choroid Plexus Tumors; Atypical/Malignant Meningioma
Intervention: Drug: Nivolumab
Sponsor: National Cancer Institute (NCI)
Recruiting -
Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer
Posted: April 11th, 2017, 2:00pm GMT
Conditions: Glioblastoma; Gliosarcoma; MGMT-Unmethylated Glioblastoma; Recurrent Glioblastoma
Interventions: Other: Laboratory Biomarker Analysis; Drug: MDM2 Inhibitor KRT-232; Other: Pharmacological Study; Radiation: Radiation Therapy
Sponsor: National Cancer Institute (NCI)
Recruiting -
Social Emotional Development in Young Children With Cancer
Posted: March 22nd, 2017, 2:00pm GMT
Conditions: Solid Tumor, Childhood; Brain Tumor, Pediatric
Intervention: Behavioral: Questionnaires
Sponsors: St. Jude Children's Research Hospital; American Cancer Society, Inc.
Recruiting -
Radiation Therapy Plus Temozolomide and Pembrolizumab With and Without HSPPC-96 in Newly Diagnosed Glioblastoma (GBM)
Posted: January 12th, 2017, 3:00pm GMT
Condition: Glioblastoma
Interventions: Drug: Pembrolizumab; Biological: HSPPC-96; Drug: Temozolomide; Other: Placebo
Sponsor: National Cancer Institute (NCI)
Recruiting -
Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases
Posted: December 15th, 2016, 3:00pm GMT
Conditions: Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm; Metastatic Malignant Neoplasm in the Brain
Interventions: Other: Laboratory Biomarker Analysis; Other: Pharmacological Study; Other: Quality-of-Life Assessment; Drug: Ropidoxuridine; Radiation: Whole-Brain Radiotherapy
Sponsor: National Cancer Institute (NCI)
Recruiting -
Cognitive Outcome After SRS or WBRT in Patients With Multiple Brain Metastases (CAR-Study B)
Posted: November 3rd, 2016, 2:00pm GMT
Condition: Neoplasm Metastasis
Interventions: Radiation: Gamma Knife radiosurgery; Radiation: Whole Brain Radiation Therapy
Sponsors: Elisabeth-TweeSteden Ziekenhuis; University of Tilburg; ZonMw: The Netherlands Organisation for Health Research and Development
Recruiting -
Pembrolizumab In Central Nervous System Metastases
Posted: September 1st, 2016, 2:00pm GMT
Condition: Brain Metastases
Interventions: Drug: Pembrolizumab; Radiation: MRI; Radiation: PET/CT; Procedure: Stereotactic Radiosurgery
Sponsors: Massachusetts General Hospital; Merck Sharp & Dohme Corp.
Recruiting -
Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA
Posted: June 15th, 2016, 2:00pm GMT
Conditions: Glioblastoma; Anaplastic Astrocytoma; Anaplastic Oligoastrocytoma; Glioma; Brain Neoplasm; Brain Cancer; Brain Tumor; Brain Tumor, Recurrent; Brain Neoplasm, Malignant
Interventions: Drug: Intra-arterial Cetuximab; Drug: Intra-arterial Mannitol; Radiation: Hypofractionated re-irradiation
Sponsor: Northwell Health
Recruiting -
Exercise Program in Cancer and Cognition
Posted: June 8th, 2016, 2:00pm GMT
Condition: Breast Cancer
Intervention: Behavioral: Moderate-Intensity Aerobic Exercise Intervention
Sponsors: University of Pittsburgh; National Institutes of Health (NIH); National Cancer Institute (NCI)
Recruiting -
Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer
Posted: February 12th, 2016, 3:00pm GMT
Conditions: Melanoma; Non-small Cell Lung Cancer; Brain Metastasis
Intervention: Drug: Pembrolizumab plus Bevacizumab
Sponsor: Yale University
Recruiting -
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
Posted: October 5th, 2015, 2:00pm GMT
Conditions: Breast Cancer; Cholangiocarcinoma; Colorectal Cancer; Head and Neck Neoplasms; Lymphoma, Large-Cell, Anaplastic; Melanoma; Neuroendocrine Tumors; Non-Small Cell Lung Cancer; Ovarian Cancer; Pancreatic Cancer; Papillary Thyroid Cancer; Primary Brain Tumors; Renal Cell Carcinoma; Sarcomas; Salivary Gland Cancers; Adult Solid Tumor
Intervention: Drug: Entrectinib
Sponsor: Hoffmann-La Roche
Recruiting -
T Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With HER2-Positive CNS Tumors
Posted: May 13th, 2015, 2:00pm GMT
Conditions: Brain Tumor, Recurrent; Brain Tumor, Refractory
Intervention: Biological: HER2-specific T cells
Sponsors: Baylor College of Medicine; Center for Cell and Gene Therapy, Baylor College of Medicine; Houston Methodist Hospital, TX
Recruiting -
Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System
Posted: March 18th, 2015, 2:00pm GMT
Conditions: Metastatic Brain Tumor; Primary Brain Tumor; Epileptic/Seizure Foci; Movement Disorders
Intervention: Device: NeuroBlate System
Sponsor: Monteris Medical
Recruiting -
Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas
Posted: November 13th, 2014, 3:00pm GMT
Conditions: Pituitary Neoplasms; Adenoma
Intervention: Drug: cabergoline
Sponsors: St. Olavs Hospital; Norwegian University of Science and Technology
Recruiting -
Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated With Cranial Radiation for Brain Tumors
Posted: June 3rd, 2014, 2:00pm GMT
Condition: Brain Tumor
Intervention: Behavioral: Physical Activity
Sponsor: National Cancer Institute (NCI)
Recruiting -
Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma
Posted: April 23rd, 2009, 2:00pm GMT
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: concomitant temozolomide (TMZ); Radiation: radiotherapy; Drug: procarbazine; Drug: adjuvant temozolomide (TMZ); Drug: CCNU; Drug: vincristine
Sponsors: Alliance for Clinical Trials in Oncology; National Cancer Institute (NCI); European Organisation for Research and Treatment Center (EORTC); Canadian Cancer Trials Group
Recruiting -
Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors
Posted: March 27th, 2009, 2:00pm GMT
Conditions: Brain Cancer; Glioma
Intervention: Procedure: MRI and advanced MRI sequences
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting -
Neurosciences Research Repository
Posted: March 9th, 2009, 2:00pm GMT
Condition: Neurological Conditions
Intervention: Other: tissue and data repository
Sponsor: The University of Texas Health Science Center, Houston
Recruiting
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