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PubMed - Adenoid Cystic Carcinoma (34 unread)

Paired related homeobox 1 attenuates autophagy via acetyl-CoA carboxylase 1-regulated fatty acid metabolism in salivary adenoid cystic carcinoma

Fetched: January 16th, 2022, 5:00am GMT by Jie Gao

FEBS Open Bio. 2022 Jan 15. doi: 10.1002/2211-5463.13367. Online ahead of print.

ABSTRACT

Autophagy can affect the invasion and metastasis of carcinoma. Our previous study has shown that invasion and epithelial-mesenchymal transition in salivary adenoid cystic carcinoma (SACC) can be promoted by the metabolic reprogramming of free fatty acids (FFAs). However, the effect of FFA metabolism on autophagy in SACC remains unknown. In this study, we showed that overexpression of paired related homeobox 1 (PRRX1) reduces the number of autophagosomes and decreases the expression of LC3 and Beclin-1 in SACC patients and SACC-83 cells in vitro. Moreover, PRRX1 mediates FFA reprogramming in response to autophagy via regulating acetyl-CoA carboxylase 1 (ACC1), leading to accelerated invasion and migration in SACC.

PMID:35032368 | DOI:10.1002/2211-5463.13367
Clinical, Radiological and Histopathological Features of Patients With Lacrimal Gland Enlargement

Fetched: January 12th, 2022, 5:00am GMT by Mansooreh Jamshidian Tehrani

Arch Iran Med. 2021 Dec 1;24(12):910-915. doi: 10.34172/aim.2021.136.

ABSTRACT

BACKGROUND: The purpose of this study was to describe the radiologic and histopathologic features of lacrimal gland in patients presenting with lacrimal gland enlargement.

METHODS: We retrospectively retrieved the data of patients with lacrimal gland enlargement in Farabi Eye Hospital between 2012 and 2017. These data included demographics, the patients' facial photographs, orbital CT-scans, and histopathological findings of lacrimal gland biopsies.

RESULTS: Forty-seven patients (15 men and 32 women) were enrolled in this study with a median age of 37.9 years (range, 15-79 years). Histopathologic diagnoses were chronic dacryoadenitis in 26 cases (55.32%), IgG4-related disease in 6 patients (12.77%), two cases of acute dacryoadenitis, two cases of non-necrotizing granulomatous inflammation, two cases of Non-Hodgkin's B-cell lymphoma, two cases of adenoid cystic carcinoma and two cases of mixed tumor (4.26% each), as well as one case of conjunctival epithelial cyst, and one case of benign lymphoid tissue and fibrofatty tissue (2.13%). In two samples (4.26%), biopsy revealed normal lacrimal glands. Interestingly, in two cases with relapsing lacrimal gland enlargement, different histopathologic diagnoses were found in biopsies taken from each lacrimal gland at different times. The average size of enlarged lacrimal glands was 19.67 mm × 7.06 mm on axial CT scan and 19.44 mm × 6.20 mm on coronal CT scan.

CONCLUSION: Tissue biopsy is needed for diagnosis of lacrimal gland enlargement because it is difficult to distinguish the type of the lacrimal gland pathology based solely on clinical or radiological presentation.

PMID:35014239 | DOI:10.34172/aim.2021.136
Bcr-TMP, a Novel Nanomolar-Active Compound That Exhibits Both MYB- and Microtubule-Inhibitory Activity

Fetched: January 12th, 2022, 5:00am GMT by Maria V Yusenko

Cancers (Basel). 2021 Dec 23;14(1):43. doi: 10.3390/cancers14010043.

ABSTRACT

Studies of the role of MYB in human malignancies have highlighted MYB as a potential drug target for acute myeloid leukemia (AML) and adenoid cystic carcinoma (ACC). Here, we present the initial characterization of 2-amino-4-(3,4,5-trimethoxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile (Bcr-TMP), a nanomolar-active MYB-inhibitory compound identified in a screen for novel MYB inhibitors. Bcr-TMP affects MYB function in a dual manner by inducing its degradation and suppressing its transactivation potential by disrupting its cooperation with co-activator p300. Bcr-TMP also interferes with the p300-dependent stimulation of C/EBPβ, a transcription factor co-operating with MYB in myeloid cells, indicating that Bcr-TMP is a p300-inhibitor. Bcr-TMP reduces the viability of AML cell lines at nanomolar concentrations and induces cell-death and expression of myeloid differentiation markers. It also down-regulates the expression of MYB target genes and exerts stronger anti-proliferative effects on MYB-addicted primary murine AML cells and patient-derived ACC cells than on their non-oncogenic counterparts. Surprisingly, we observed that Bcr-TMP also has microtubule-disrupting activity, pointing to a possible link between MYB-activity and microtubule stability. Overall, Bcr-TMP is a highly potent multifunctional MYB-inhibitory agent that warrants further investigation of its therapeutic potential and mechanism(s) of action.

PMID:35008207 | PMC:PMC8750090 | DOI:10.3390/cancers14010043
99mTc-MIBI SPECT/CT and FDG PET/CT in Isolated Bilateral Renal Metastases From Adenoid Cystic Carcinoma of the Maxilla

Fetched: January 11th, 2022, 5:00am GMT by Qian Zhao

Clin Nucl Med. 2022 Feb 1;47(2):e205-e207. doi: 10.1097/RLU.0000000000003872.

ABSTRACT

Renal metastasis from adenoid cystic carcinoma of the head and neck is uncommon. We present 99mTc-MIBI SPECT/CT and FDG PET/CT findings in a case with isolated bilateral renal metastases from adenoid cystic carcinoma of the left maxilla. The metastatic adenoid cystic carcinomas of the kidneys showed photopenia on 99mTc-MIBI SPECT/CT and increased FDG uptake on FDG PET/CT mimicking primary renal cell carcinoma.

PMID:35006121 | DOI:10.1097/RLU.0000000000003872
68Ga-Prostate-Specific Membrane Antigen-Avid Malignant Pleural Effusion in a Patient With Metastatic Adenoid Cystic Carcinoma and Concordance With 18F-FDG PET/CT

Fetched: January 11th, 2022, 5:00am GMT by Maike José Maria Uijen

Clin Nucl Med. 2022 Feb 1;47(2):140-141. doi: 10.1097/RLU.0000000000004015.

ABSTRACT

Adenoid cystic carcinoma (ACC) is a rare cancer that arises from salivary glands and other secretory glands. Pulmonary metastases are frequently observed in ACC patients with metastatic disease. Previous research showed that ACC often shows high PSMA uptake on 68Ga-PSMA-11 PET/CT. Here, we present PET images from an ACC patient with pulmonal, pleural metastases, and malignant pleural effusion, with comparable tracer uptake on 68Ga-PSMA-11 PET and 18F-FDG PET.

PMID:35006109 | PMC:PMC8746899 | DOI:10.1097/RLU.0000000000004015
Adenoid cystic carcinoma: A case of rare breast cancer

Fetched: January 11th, 2022, 5:00am GMT by Claudia Gordillo

Radiol Case Rep. 2021 Dec 28;17(3):690-692. doi: 10.1016/j.radcr.2021.12.030. eCollection 2022 Mar.

ABSTRACT

Adenoid cystic carcinoma is a rare form of breast cancer accounting for 0.1%-1.0% of all mammary malignancies. It is characterized by an indolent clinical course and favorable prognosis, contrary to other breast cancers. Diagnostic mammogram and breast ultrasound play a pivotal role in the early detection and diagnosis of breast adenoid cystic carcinoma. Treatment may consist of lumpectomy and radiation therapy vs mastectomy alone. Even though rare, late disease recurrence and metastasis has been reported in the literature thus long-term surveillance is of utmost importance for these patients. We will review the literature and discuss the case of a 52-year-old female who presented with a palpable lump of the right breast, which was pathologically proven to be adenoid cystic carcinoma of the breast.

PMID:35003461 | PMC:PMC8715290 | DOI:10.1016/j.radcr.2021.12.030
Prognostic Significance of Cancer Stem Cell Markers in Patients With Salivary Gland Carcinomas

Fetched: January 11th, 2022, 5:00am GMT by Hanieh Sadeghi

Appl Immunohistochem Mol Morphol. 2022 Jan 10. doi: 10.1097/PAI.0000000000001006. Online ahead of print.

ABSTRACT

OBJECTIVES: Cancer stem cells (CSCs) are a small group of cells resistant to therapy and play a major role in tumor progression, recurrence, and poor clinical outcomes of patients. This study aimed to evaluate the association of CSC markers with clinicopathologic features and survival in patients with salivary gland carcinomas (SGCs).

MATERIALS AND METHODS: The medical records of 48 patients affected by mucoepidermoid carcinoma (MEC) and 47 patients with adenoid cystic carcinoma (AdCC) were reviewed retrospectively. SOX2, CD133, and CD44 expression was appraised by immunohistochemistry and statistically analyzed to weigh the correlation between these markers and patients' clinicopathologic features and tumor outcomes.

RESULTS: In AdCC patients showing poor outcomes, a trend toward a high expression of CD133 and CD44 and low expression of SOX2 was observed, while in MEC patients experiencing the same outcomes, there was a trend toward a high expression of CD44 and low expression of CD133 and SOX2. Only the increase of MEC histopathologic grade was statistically significant with decreased SOX2 expression. Distant metastasis in AdCC patients, tumor grade, lymph node involvement, and local recurrence in MEC patients had significant correlations with patients' survival.

CONCLUSION: Besides the significant association between low SOX2 expression and higher grades of MEC, we found no statistically significant correlation between the studied CSC markers and patients' survival or clinicopathologic features. Therefore, a larger sample size with long-term follow-up is beneficial for thorough investigations toward the main role of CSCs in patients with SGCs.

PMID:35001035 | DOI:10.1097/PAI.0000000000001006
Transcription factor c-Myb: novel prognostic factor in osteosarcoma

Fetched: January 8th, 2022, 5:00am GMT by Kamila Říhová

Clin Exp Metastasis. 2022 Jan 7. doi: 10.1007/s10585-021-10145-4. Online ahead of print.

ABSTRACT

The transcription factor c-Myb is an oncoprotein promoting cell proliferation and survival when aberrantly activated/expressed, thus contributing to malignant transformation. Overexpression of c-Myb has been found in leukemias, breast, colon and adenoid cystic carcinoma. Recent studies revealed its expression also in osteosarcoma cell lines and suggested its functional importance during bone development. However, the relevance of c-Myb in control of osteosarcoma progression remains unknown. A retrospective clinical study was carried out to assess a relationship between c-Myb expression in archival osteosarcoma tissues and prognosis in a cohort of high-grade osteosarcoma patients. In addition, MYB was depleted in metastatic osteosarcoma cell lines SAOS-2 LM5 and 143B and their growth, chemosensitivity, migration and metastatic activity were determined. Immunohistochemical analysis revealed that high c-Myb expression was significantly associated with poor overall survival in the cohort and metastatic progression in young patients. Increased level of c-Myb was detected in metastatic osteosarcoma cell lines and its depletion suppressed their growth, colony-forming capacity, migration and chemoresistance in vitro in a cell line-dependent manner. MYB knock-out resulted in reduced metastatic activity of both SAOS-2 LM5 and 143B cell lines in immunodeficient mice. Transcriptomic analysis revealed the c-Myb-driven functional programs enriched for genes involved in the regulation of cell growth, stress response, cell adhesion and cell differentiation/morphogenesis. Wnt signaling pathway was identified as c-Myb target in osteosarcoma cells. Taken together, we identified c-Myb as a negative prognostic factor in osteosarcoma and showed its involvement in the regulation of osteosarcoma cell growth, chemosensitivity, migration and metastatic activity.

PMID:34994868 | DOI:10.1007/s10585-021-10145-4
Response of NOTCH1-Activated Tracheal Adenoid Cystic Carcinoma to the Gamma Secretase Inhibitor Nirogacestat

Fetched: January 8th, 2022, 5:00am GMT by Rosalind Kieran

JCO Precis Oncol. 2021 Nov;5:1579-1583. doi: 10.1200/PO.21.00228.

NO ABSTRACT

PMID:34994644 | DOI:10.1200/PO.21.00228
Adjuvant radiotherapy in malignant tumors of parotid. Experience of the Navarra Hospital Complex

Fetched: January 8th, 2022, 5:00am GMT by Maitane Rodrigez Mendizábal

Rep Pract Oncol Radiother. 2021 Dec 30;26(6):962-967. doi: 10.5603/RPOR.a2021.0118. eCollection 2021.

ABSTRACT

BACKGROUND: The objective of the study was to review the outcome of patients with parotid cancer treated with postoperative radiotherapy at Complejo Hospitalario de Navarra in the last ten years.

MATERIALS AND METHODS: We retrospectively reviewed patients treated with adjuvant radiotherapy between January 2008 and December 2018. We analyzed demographic data, histopathologic findings, local control (LC) and overall survival (OS).

RESULTS: A total of 40 patients received postoperative radiotherapy during the period mentioned. There were 22 men (55%) and 18 women (45%). Median age was 58 years (19-90). By tumor histology, the most common was squamous cell carcinoma (22.5%) followed by ex-pleomorphic adenoma (15%) and adenoid cystic carcinoma (10%). According to Surgery, 19 patients (47.5%) underwent a total parotidectomy, 20 (50%) partial parotidectomy, and 1 (2.5%) a radical parotidectomy. Twenty-one patients (51.2%) underwent cervical dissection, most of them being supraomohyoid (31.7%). Reasons for adjuvant RT were: R1 resection (35% of the patients), high grade tumors (27.5%) and 17.5% because R1 surgery and R1. Radiation was administered using IMRT in most patients to a total dose of 60 Gy in 30 fractions. The 5-year overall survival (OS) (Kaplan-Meier) was 81% (95% CI: 68.5-96.2%), and 10-years - 64%. The 5-year local control (LC) (Kaplan-Meier) was 82.4% (95% CI: 91.46-73.33%) and the 10-year LC - 72.2% (95% CI: 54.9-96%). To date, only 4 patients (10%) have died due to their parotid tumor.

CONCLUSION: The adjuvant radiotherapy added to surgery, significantly reduces the risk of recurrence in high-risk patients with a very acceptable survival rate.

PMID:34992869 | PMC:PMC8726456 | DOI:10.5603/RPOR.a2021.0118
Acquired nasolacrimal duct obstruction: clinical and histological findings of 275 cases

Fetched: January 7th, 2022, 5:00am GMT by Almantas Makselis

BMC Ophthalmol. 2022 Jan 5;22(1):12. doi: 10.1186/s12886-021-02185-x.

ABSTRACT

BACKGROUND: Acquired nasolacrimal duct obstruction is a blockage of the lacrimal outflow system usually caused by local nonspecific inflammation of the lacrimal sac and the nasolacrimal duct. However, cases exist where the primary nasolacrimal system obstruction is caused by malignancies. Our aim was to investigate lacrimal sac pathologies in patients with acquired nasolacrimal duct obstruction and compare their clinical manifestations.

METHODS: This retrospective clinical study included 275 patients with acquired nasolacrimal duct obstruction who underwent external dacryocystorhinostomy and lacrimal sac biopsy. Cases were classified into tumor or nonspecific pathology groups and subdivided according to the level of inflammation. Histological and clinical data were analyzed.

RESULTS: Three tumors (1.1%) (an adenoid cystic carcinoma, an eccrine spiradenoma and small B cell lymphoma) were diagnosed. Chronic nongranulomatous inflammation was the most common histological finding, corresponding to 194 cases (70.5%). The other 81 (29.5%) were subacute, acute forms of nongranulomatous inflammation, tumors and fibrosis cases. Epiphora with continuous purulent discharge was the most common clinical sign reported by 144 (52.4%) patients, and two (0.7%) patients had a palpable mass near the medial canthal tendon, which was identified as an eccrine spiradenoma and small B cell lymphoma. There was no significant difference in the clinical symptoms, duration or case history between the nonspecific pathology and tumor groups (p = 0.292).

CONCLUSIONS: Chronic nongranulomatous inflammation of the lacrimal sac was the most common finding among acquired nasolacrimal duct obstruction cases. There were no associations between the histological findings and clinical presentation. The authors recommend a lacrimal sac biopsy only in cases when a tumor is clinically suspected.

PMID:34986808 | PMC:PMC8734260 | DOI:10.1186/s12886-021-02185-x
EMT in salivary gland tumors: the expression of microRNAs miR-155 and miR-200c is associated with clinical-pathological parameters

Fetched: January 5th, 2022, 5:00am GMT by Leandra Ernst Kerche

Mol Biol Rep. 2022 Jan 4. doi: 10.1007/s11033-021-07033-1. Online ahead of print.

ABSTRACT

BACKGROUND: Epithelial to mesenchymal transition promotes cell adhesion loss, enabling invasion and metastasis. MicroRNAs are a class of small non-codifying RNAs that regulate gene expression.

OBJECTIVES: The aim of this study was to evaluate the expression of microRNAs that could regulate the expression of EMT factors in salivary gland tumors (SGTs).

METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples. Bioinformatics tools were applied to identify miR targets and immunohistochemistry was used to examine the expression of the proteins E-cadherin, Twist, ZEB-1, β-Catenin, and c-Kit. Comparing miR expression among SGT types, we observed increased expression of miR-9, and miR-138 in PAs, and increased miR-155 expression in MECs. Low-grade MECs exhibited increased miR-155 expression (p = 0.032). MECs that generated lymph node metastases had increased miR-200c levels (p = 0.018). MECs tended to have decreased expression of EMT-related proteins when compared to the other SGT types (c-Kit p < 0.001, Twist p = 0.014, and ZEB p = 0.012). Notably, increased c-Kit expression was associated with the presence of perineural infiltration in ACC (p = 0.050).

CONCLUSIONS: This study provides evidence of alterations in the expression of EMT-factors regulating miRs, especially of miR-9, miR-138, miR-155, and miR-200c. No significant relationships were found between the expression of these miRs and proteins associated with EMT in SGTs.

PMID:34981333 | DOI:10.1007/s11033-021-07033-1
Low-grade triple-negative breast carcinomas. A report of 2 cases and an update of current concepts

Fetched: January 5th, 2022, 5:00am GMT by Juan Ruiz

Rev Esp Patol. 2022 Jan-Mar;55(1):26-35. doi: 10.1016/j.patol.2021.01.006. Epub 2021 Feb 27.

ABSTRACT

Triple negative breast cancer is defined by the lack of expression of estrogen, progesterone and HER2 receptors. Significant molecular, morphological and clinical heterogeneity is present in this group of neoplasms. Although the majority are high-grade tumors, low-grade triple negative breast cancers can occur and their evolution, molecular characteristics and therapeutic management vary from the former. In the current review, we focus on the histological and immunohistochemical phenotypes of two new low-grade cases: an acinic cell carcinoma and an adenoid cystic carcinoma. Data originated from the pathology department of a third-level hospital over an 18-month period, within a breast cancer screening program. Low-grade triple negative cancers should be suspected in triple negative breast cancers with low proliferative rates as, unlike high-grade tumors, they require a multidisciplinary approach. They can be diagnosed at an early stage by immunohistochemistry using core needle biopsy.

PMID:34980437 | DOI:10.1016/j.patol.2021.01.006
Adenoid cystic carcinoma with a leptomeningeal dissemination in a 'wash' pattern

Fetched: January 2nd, 2022, 5:00am GMT by Juan Daniel Prieto Cuadra

BMJ Case Rep. 2021 Dec 31;14(12):e247155. doi: 10.1136/bcr-2021-247155.

ABSTRACT

A 39-year-old woman was referred to the neurology department due to headache, instability and difficulty walking for 5 months. Several ancillary tests were performed. The blood test showed leucocytosis and the cerebrospinal fluid revealed an increased total protein and glucose consumption. Other infections or autoimmune causes were excluded. The MRI showed non-specific brain and spinal cord lesions. Given the findings described, a differential diagnosis between granulomatous meningoencephalitis and primary tumour or metastasis was proposed. Empirical treatment with tuberculostatic agents and corticosteroids was started. The neurological state of the patient worsened, she fell into a non-responsive coma and died in few days. The clinical autopsy performed revealed an adenoid cystic carcinoma with involvement of the central nervous system that developed leptomeningeal dissemination along the spinal cord in a fluid 'wash' pattern.

PMID:34972782 | PMC:PMC8720991 | DOI:10.1136/bcr-2021-247155
Salivary Microbiome in Adenoid Cystic Carcinoma Detected by 16S rRNA Sequencing and Shotgun Metagenomics

Fetched: January 1st, 2022, 5:00am GMT by Qian Jiang

Front Cell Infect Microbiol. 2021 Dec 14;11:774453. doi: 10.3389/fcimb.2021.774453. eCollection 2021.

ABSTRACT

Microorganisms are confirmed to be closely related to the occurrence and development of cancers in human beings. However, there has been no published report detailing relationships between the oral microbiota and salivary adenoid cystic carcinoma (SACC). In this study, unstimulated saliva was collected from 13 SACC patients and 10 healthy controls. The microbial diversities, compositions and functions were comprehensively analyzed after 16S rRNA sequencing and whole-genome shotgun metagenomic sequencing. The alpha diversity showed no significant difference between SACC patients and healthy controls, while beta diversity showed a separation trend. The SACC patients showed higher abundances of Streptococcus and Rothia, while Prevotella and Alloprevotella were more abundant in healthy controls. The prevalent KEGG pathways, carbohydrate-active enzymes, antibiotic resistances and virulence factors as well as the biomarkers in SACC were determined by functional gene analysis. Our study preliminarily investigated the salivary microbiome of SACC patients compared with healthy controls and might be the basis for further studies on novel diagnostic and treatment strategies.

PMID:34970508 | PMC:PMC8712576 | DOI:10.3389/fcimb.2021.774453
Male Adenoid Cystic Carcinoma of the Breast

Fetched: January 1st, 2022, 5:00am GMT by Jie Xiao Li

J Med Cases. 2021 Dec;12(12):503-510. doi: 10.14740/jmc3790. Epub 2021 Dec 2.

ABSTRACT

Adenoid cystic carcinoma (ACC) of the breast, a rare malignancy that makes up less than 0.1% of all breast malignancies, is much rarer in males than in females. Due to the rarity of this disease, an optimal treatment strategy for male breast ACC has not been established, and therapy for male patients is currently based on guidelines for female patients. According to previous reported cases, some authors believe that male breast ACC may have higher invasive potential than female breast ACC and the prognoses in male patients may be worse than those in female patients. Therefore, a more proactive diagnosis and treatment regimen may be required. However, the clinical feature of our case is inconsistent with this view. Herein we report the case of a 24-year-old male without any antecedent medical or family history who presented with a slow-growing lump on his left chest wall for 5 years. The patient initially underwent lumpectomy, and the mass was pathologically diagnosed as breast ACC. Systemic examination was performed, and no evidence of distant metastasis was found. Then, he received modified radical mastectomy and ipsilateral axillary lymph node dissection. The mastectomy pathological examination revealed that no cancerous tissue was detected around the primary tumor bed, and all 22 axillary lymph nodes were negative. The patient did not receive postoperative chemotherapy, radiotherapy or endocrine therapy and remained well after 28 months of follow-up. In this study, we review the literature and summarize the clinical manifestations, imaging and histopathological characteristics, treatments and outcomes of male breast ACC. We share our experience in the hopes that this evidence will aid in the development of better therapeutics.

PMID:34970375 | PMC:PMC8683108 | DOI:10.14740/jmc3790
In Silico Feasibility Study of Carbon Ion Radiotherapy With Simultaneous Integrated Boost for Head and Neck Adenoid Cystic Carcinoma

Fetched: December 31st, 2021, 5:00am GMT by Edoardo Mastella

Front Oncol. 2021 Dec 13;11:772580. doi: 10.3389/fonc.2021.772580. eCollection 2021.

ABSTRACT

PURPOSE: In carbon ion radiotherapy (CIRT), a simultaneous integrated boost (SIB) approach has not been fully exploited so far. The feasibility of a CIRT-SIB strategy for head and neck adenoid cystic carcinoma (ACC) patients was investigated in order to improve treatment planning dose distributions.

METHODS AND MATERIALS: CIRT plans of 10 ACC patients treated at the National Center for Oncological Hadrontherapy (CNAO, Pavia, Italy) with sequential boost (SEQ) irradiation and prescription doses of 41.0 Gy [relative biological effectiveness (RBE)]/10 fractions to low-risk (LR) clinical target volume (CTV) plus 24.6 Gy(RBE)/6 fractions to the high-risk (HR) CTV were re-planned with two SIB dose levels to the LR-CTV, namely, 48.0 Gy(RBE) and 54.4 Gy(RBE). While planning with SIB, the HR-CTV coverage had higher priority, with fixed organ-at-risk dose constraints among the SIB and SEQ plans. The homogeneity and conformity indexes were selected for CTV coverage comparison. The biologically effective dose (BED) was calculated to compare the different fractionation schemes.

RESULTS: Comparable HR-CTV coverage was achieved with the treatment approaches, while superior conformality and homogeneity were obtained with the SIB technique in both CTVs. With the SEQ, SIB48.0, and SIB54.4, the LR-CTV median doses were respectively 50.3%, 11.9%, and 6.0% higher than the prescriptions. Significant reductions of the median and near-maximum BEDs were achieved with both SIB dose levels in the LR-CTV.

CONCLUSIONS: The SIB approach resulted in highly conformal dose distributions with the reduction of the unintended dose to the LR-CTV. A prescription dose range for the LR-CTV will be clinically defined to offer tailored personalized treatments, according to the clinical and imaging characteristics of the patients.

PMID:34966678 | PMC:PMC8710479 | DOI:10.3389/fonc.2021.772580
Clinical and demographic features of minor salivary gland tumors: A collaborative study of 480 cases

Fetched: December 30th, 2021, 5:00am GMT by Fábio Fernandes Borém Bruzinga

Oral Dis. 2021 Dec 29. doi: 10.1111/odi.14119. Online ahead of print.

ABSTRACT

OBJECTIVE: Describe the frequency, clinical, and demographic features of minor salivary gland tumors and possible associated factors.

MATERIALS AND METHODS: A cross-sectional study was conducted. Clinical and demographic data were collected from biopsy records of two oral pathology services. Chi-square test, Fisher's exact test, and descriptive statistical analysis were performed.

RESULTS: A total of 480 (0.89%) minor salivary gland tumors were retrieved; 272 (56.7%) benign and 147 (30.7%) malignant. Sixty-one (12.6%) had no subtype specification. Most patients were female (307/64.0%), in sixth decade of life (80/16.7%), with a mean age of 45.32 years. Palate was the most common site (336/70.1%). Pleomorphic adenoma (PA) (245/51.1%), mucoepidermoid carcinoma (MEC) (70/14.6%), and adenoid cystic carcinoma (ACC) (43/8.9%) were the most frequent tumors. Symptomatic case, recurrence, and tobacco use were associated with malignancy (p<0.05). PA and MEC were more frequent in palate (p<0.05). No association between the three most frequent histological types and gender or age group was observed (p>0.05).

CONCLUSION: This represents one of the largest exclusively series of minor salivary gland tumors in Brazil and worldwide. PA, MEC, and ACC were the most frequent tumors. Clinical and demographic data are similar from Brazilian studies or from other countries.

PMID:34965007 | DOI:10.1111/odi.14119
Sublingual Gland Carcinoma Revealed by Choroidal Metastasis

Fetched: December 28th, 2021, 5:00am GMT by Tetsuro Morita

Acta Med Okayama. 2021 Dec;75(6):741-744. doi: 10.18926/AMO/62815.

ABSTRACT

A 65-year-old man presented with a 1-week history of left eye distortion. An elevated choroidal lesion covering 6 disc diameters was found in the posterior retina of the left eye. Systemic examination revealed sublingual gland carcinoma and multiple lung metastases, and the diagnosis was choroidal metastasis from sublingual gland carcinoma. Following chemotherapy and radiation therapy, the choroidal lesion shrunk and the patient's visual acuity improved. The patient died 23 months after his first visit. To the best of our knowledge, this is the first reported case of choroidal metastasis from sublingual gland carcinoma.

PMID:34955543 | DOI:10.18926/AMO/62815
Primary adenoid cystic carcinoma of thyroid gland: A case report

Fetched: December 28th, 2021, 5:00am GMT by Zhong-Qi Sun

Asian J Surg. 2021 Dec 23:S1015-9584(21)00762-4. doi: 10.1016/j.asjsur.2021.11.041. Online ahead of print.

NO ABSTRACT

PMID:34955347 | DOI:10.1016/j.asjsur.2021.11.041
Photodynamic therapy for primary tracheobronchial malignancy in Northwestern China

Fetched: December 28th, 2021, 5:00am GMT by Qian Zhang

Photodiagnosis Photodyn Ther. 2021 Dec 23;37:102701. doi: 10.1016/j.pdpdt.2021.102701. Online ahead of print.

ABSTRACT

BACKGROUND: Photodynamic therapy (PDT) has been routinely performed to treat tracheobronchial malignancy. However, the experience in tracheobronchial adenoid cystic carcinoma (ACC) and peripheral lung cancer is still insufficient. This study aimed to share the experience of PDT for patients with primary tracheobronchial malignancy, especially the adenoid cystic carcinoma and peripheral lung cancer, and evaluated the efficacy and safety of PDT in Northwestern Chinese patients.

METHODS: This study retrospectively analyzed the clinical data of 23 patients with primary tracheobronchial malignancy receiving PDT in our center. The short-term effect was evaluated by the objective tumor response and the clinical response. The long-term effect was estimated by recurrence-free survival (RFS).

RESULTS: Of 23 patients, SR was achieved in 18 patients and MR in 3 patients. The clinical symptoms and the quality of life were significantly improved after PDT (P<0.05). And the mean RFS was 8.9 ± 1.9 months. SR for 6 cases of ACC were achieved with significant improvement of clinical symptoms and quality of life. No procedure-related complications appeared. And PDT was successfully performed for the peripheral lung cancer with the guidance of electromagnetic navigation bronchoscopy (ENB).

CONCLUSIONS: This study demonstrated that PDT achieved satisfactory efficacy and safety for Northwestern Chinese patients with primary tracheobronchial malignancy. Patients with ACC can benefit from PDT. And ENB-guided PDT is a novel and available option for the peripheral lung cancer. In short, this study accumulated valuable experience for the application of PDT in Chinese patients with primary tracheobronchial malignancy.

PMID:34954091 | DOI:10.1016/j.pdpdt.2021.102701
Prognostic Relevance of Thyroid-Hormone-Associated Proteins in Adenoid Cystic Carcinoma of the Head and Neck

Fetched: December 25th, 2021, 5:00am GMT by Julia Schnoell

J Pers Med. 2021 Dec 12;11(12):1352. doi: 10.3390/jpm11121352.

ABSTRACT

The proteins sodium iodide symporter (NIS), μ-crystallin (CRYM), and thyroid hormone receptor beta (THRB) have been associated with prognosis in various cancer entities. While NIS and THRB may serve as possible therapeutic targets, the role of CRYM in cancer is still unclear. Protein levels of 44 patients with adenoid cystic carcinoma of the head and neck were analyzed using immunohistochemistry and correlated with clinicopathological data and outcome. NIS was positive in 72%, CRYM was positive in 55%, and THRB was positive in 39% of the patients. CRYM-positive adenoid cystic carcinomas were associated with a better cause-specific survival. Thus, our data indicate that CRYM might be a suitable positive prognostic marker in adenoid cystic carcinoma of the head and neck. Furthermore, expression of NIS was present in most patients and therefore evaluation of the use of radioiodine treatment is recommended.

PMID:34945824 | PMC:PMC8703850 | DOI:10.3390/jpm11121352
Radiation Therapy for Adenoid Cystic Carcinoma of the Head and Neck

Fetched: December 25th, 2021, 5:00am GMT by Carlos A Rodriguez-Russo

Cancers (Basel). 2021 Dec 17;13(24):6335. doi: 10.3390/cancers13246335.

ABSTRACT

Adenoid cystic carcinoma of the head and neck is an uncommon malignancy that can arise in the major or minor salivary glands. Perineural invasion (PNI) is an extremely frequent finding in cases of adenoid cystic carcinoma (ACC) that can be associated with significant patient morbidity and poor prognosis. By contrast, ACC rarely demonstrates lymphovascular space invasion thereby making PNI the major avenue for metastasis and a driver of treatment rationale and design. Radiotherapy is often utilized post-operatively to improve locoregional control or as a primary therapy in unresectable disease. Here we aim to review the role of radiotherapy in the management of this malignancy with a focus on target delineation and treatment regimens in the definitive, recurrent, and metastatic settings.

PMID:34944955 | PMC:PMC8699151 | DOI:10.3390/cancers13246335
Lysosomal and cytoskeletal events in epithelial salivary tumours as assessed by imunohistochemistry for CD63 and HSP27

Fetched: December 25th, 2021, 5:00am GMT by Asterios Triantafyllou

Pathol Res Pract. 2021 Nov 21;229:153691. doi: 10.1016/j.prp.2021.153691. Online ahead of print.

ABSTRACT

Little attention has been paid to immunohistochemically assessed, lysosomal activities in salivary neoplasia. In an attempt to remedy this, the present investigation applied immunohistochemistry for CD63 antigen (a lysosomal membranous protein) and HSP27 (a molecular chaperone with roles in intracellular homeostasis) to archival paraffin-embedded surgical specimens of 101 benign and malignant, epithelial salivary tumours. Diffuse cytoplasmic CD63 immunoreactivity was seen in serous cells in acinic cell carcinoma, and mucous cells in mucoepidermoid carcinoma, pleomorphic adenoma (PA) and Warthin tumour. Apical rims or bands of CD63 immunoreactivity were also seen in simple cells lining tubular structures in PA, acinic cell carcinoma, mucoepidermoid carcinoma and polymorphous (low-grade) adenocarcinoma; and, occasionally, oncocytic luminal cells in Warthin tumour. HSP27 immunoreactivity was usually seen in non-luminal cells of PA, basal cells of oncocytic tumours, epidermoid cells of mucoepidermoid carcinoma and PA, and cells outlining aggregates or pseudolumina of adenoid cystic carcinoma. Expression of CD63 is preferentially associated with differentiated or simple luminal cell phenotypes in epithelial salivary tumours and possibly reflects autophagy of secretory granules or absorption of luminal material. Expression of HSP27 is preferentially associated with non-luminal cells and possibly reflects remodelling of the cytoskeleton.

PMID:34942509 | DOI:10.1016/j.prp.2021.153691
Roles of skull base surgery and particle radiotherapy for orbital malignant tumors involving the skull base

Fetched: December 24th, 2021, 5:00am GMT by Masanori Teshima

Laryngoscope Investig Otolaryngol. 2021 Oct 28;6(6):1347-1352. doi: 10.1002/lio2.687. eCollection 2021 Dec.

ABSTRACT

PURPOSE: To investigate the oncological outcomes of orbital malignant tumors invading the skull base.

METHODS: A retrospective analysis was conducted on 16 patients with orbital malignant tumors invading the skull base. Eleven patients were treated with skull base surgery, four patients were treated with particle therapies, and one patient was treated with chemoradiotherapy (CRT) as initial treatment.

RESULTS: The most frequent histological type was adenoid cystic carcinoma in seven patients, followed by squamous cell carcinoma in two patients. Local recurrence occurred in two of the six surgically treated patients who did not receive postoperative radiotherapy (RT) or CRT. One of them was successfully salvaged by RT, and the other died of disease. With a median follow-up of 24 months, the 2-year overall, local control, and disease-free survival rates of all patients were 82.5%, 87.5%, and 59%, respectively.

CONCLUSIONS: Patients with positive surgical margins were at risk of local recurrence. Postoperative RT should be considered for all surgically treated patients.Level of Evidence: 4.

PMID:34938873 | PMC:PMC8665474 | DOI:10.1002/lio2.687
High-Grade Transformation in Adenoid Cystic Carcinoma of the Bartholin Gland: Case Report

Fetched: December 23rd, 2021, 5:00am GMT by Aline Evangelista Santiago

Rev Bras Ginecol Obstet. 2021 Dec;43(12):980-984. doi: 10.1055/s-0041-1736301. Epub 2021 Dec 21.

ABSTRACT

INTRODUCTION: In the present study, we report a case of primary adenoid cystic carcinoma (ACC) of the Bartholin gland with high-grade transformation (HGT). Adenoid cystic carcinoma of the Bartholin gland is a rare tumor and HGT has only been reported in head and neck tumors.

CASE REPORT: A 77-year-old woman with a non-ulcerated vulvar lesion on the topography of the right Bartholin gland. The patient was submitted to tumor resection followed by V-Y island flap and adjuvant radiotherapy. The histopathological examination revealed primary ACC of the Bartholin gland, with areas of HGT and extensive perineural invasion. The immunohistochemical study with p53 showed a diffuse and strong positive reaction in areas with HGT. After 24 months of follow-up, the patient presented distant metastases and died, despite having undergone to chemotherapy.

CONCLUSION: As far as we know, this case is the first description in the literature of HGT in ACC of the Bartholin gland, and HGT appears to be associated with tumor aggressiveness.

PMID:34933392 | DOI:10.1055/s-0041-1736301
Basaloid squamous cell carcinoma of anal canal with adenoid cystic pattern and liver metastasis: A rare case report

Fetched: December 22nd, 2021, 5:00am GMT by Usha Rani

Diagn Cytopathol. 2021 Dec 21. doi: 10.1002/dc.24918. Online ahead of print.

ABSTRACT

Anal malignancies are rare, and of these squamous cell carcinoma and basaloid squamous cell carcinoma are the most common types. Anal basaloid squamous carcinoma (BSC) can show a variety of patterns including unusual variants with cribriform areas resembling adenoid cystic carcinoma (ACC). BSC is reported more frequently in elderly females. Although the histopathology of BSC is characteristic, its cytomorphology is rarely described in the anorectal region. Due to overlapping morphological features, it is challenging to distinguish between ACC and BSC. Immunohistochemistry (IHC) is mandatory for this distinction and definite diagnosis, as it is a highly aggressive tumor with a tendency for distant metastasis. An interesting and rare case of BSC with ACC-pattern arising in the anal canal with liver metastasis in a middle-aged male is reported here. The aim is to highlight its cytological features, correlation with histology, IHC and its differential diagnoses.

PMID:34931759 | DOI:10.1002/dc.24918
Expression of Programmed Cell Death-L1 (PD-L1) Protein and Mismatch Repair Mutations in Orbital Tumours-a Pilot Study

Fetched: December 22nd, 2021, 5:00am GMT by Mohammad A AlSemari

Eur J Ophthalmol. 2021 Dec 21:11206721211066203. doi: 10.1177/11206721211066203. Online ahead of print.

ABSTRACT

PURPOSE: Programmed cell death protein 1 (PD-1) and DNA mismatch repair (MMR) deficiency play an important role in tumour progression and response to treatment.Both markers have been studied in some ocular tumours but little is known about these markers in orbital tumours. This pilot study reports on PD-L1 expression and MMR mutations using next generation sequencing (NGS) in specific orbital tumours.

METHODS: We reviewed surgical specimens from patients with rhabdomyosarcoma, adenoid cystic carcinoma (ACC), pleomorphic adenoma (PA) and biopsy negative tissue from orbital tumours used as a control. immunohistochemistry (IHC) was performed on Formalin fixed paraffin embedded tissue using a PD-L1 antibody. DNA was extracted for targeted gene panel NGS of the MMR genes PMS2, MLH1, MSH6 and MSH2.

RESULTS: The study included 17 orbital specimens. Scattered membrane PD-L1 staining was noted in 3/6 rhabdomyosarcoma specimens without an accompanying lymphocytic infiltrate. PD-L1 immunostaining was absent in 3/3 ACC, and 5/6 PA specimens. PD-L1 immunostaining was not detected in 2/2 control specimens. 4/17 samples shared the same pathogenic mutation in the MLH1 gene, including 3/6 rhabdomyosarcoma and 1/3 ACC samples. 1/6 PA samples had a mutation in MSH6.

CONCLUSIONS: Our study demonstrated scattered, non-quantifiable or absent PD-L1 staining in a limited sample of orbital tumours suggesting that PD-1/PD-L1 inhibitor therapy may not be useful in treatment of malignant orbital tumours (rhabdomyosarcoma and ACC) when refractory to conventional therapy. Our pilot study suggest that PD-L1/MMR axis might not play a major role in the pathogenesis of primary orbital tumour.

PMID:34931541 | DOI:10.1177/11206721211066203
Oligometastatic adenoid cystic carcinoma: Correlating tumor burden and time to treatment with outcomes

Fetched: December 21st, 2021, 5:00am GMT by Kevin Tyan

Head Neck. 2021 Dec 19. doi: 10.1002/hed.26964. Online ahead of print.

ABSTRACT

BACKGROUND: There is limited information on the management and outcomes of oligometastases (OM) in adenoid cystic carcinoma (ACC).

METHODS: Retrospective study of 42 patients with metastatic ACC of the head and neck. Imaging studies were analyzed to identify patients with OM (1-5 lesions) at any point during follow-up.

RESULTS: There was radiographic evidence of OM in 33/42 (79%) patients. Eighteen patients had OM when treated for metastases, with median overall survival (OS) of 36.0 versus 9.2 years for patients with polymetastases (6+ lesions, HR 0.38, 95%CI 0.14-0.89). Earlier locally ablative treatment, but not systemic treatment, of patients with OM predicted improved survival 3 years after metastasis (HR 0.15, 95%CI 0.02-0.63) and postponed systemic treatment by 80 more months (HR 0.22, 95%CI 0.07-0.71).

CONCLUSIONS: There is a considerable population of ACC patients with detectable oligometastases, and early locally ablative treatment of oligometastases may be associated with improved outcomes.

PMID:34927307 | DOI:10.1002/hed.26964
Syringomatous Adenoma of the Nipple in a Male Breast: A Case Report With a Brief Review of Literature and Histomorphological Approach to Diagnosis

Fetched: December 21st, 2021, 5:00am GMT by Rajaguru Paramaguru

Cureus. 2021 Nov 15;13(11):e19586. doi: 10.7759/cureus.19586. eCollection 2021 Nov.

ABSTRACT

Syringomatous adenoma of the nipple (SAN) is a benign and locally infiltrative lesion possibly arising from the sweat gland ducts in the nipple-areolar region. This rare lesion has been reported in the female breast; however, reports on the male breast are extremely rare. Although benign, SAN has a high risk of recurrence. The clinical presentation and histomorphological features often mimic a malignancy. Hence, an awareness of this lesion is required to make a correct diagnosis. In this report, we describe the histomorphological features of SAN in a male breast.

PMID:34926057 | PMC:PMC8671072 | DOI:10.7759/cureus.19586
Excessive toxicity of cabozantinib in a phase II study in patients with recurrent and/or metastatic salivary gland cancer

Fetched: December 19th, 2021, 5:00am GMT by Wim van Boxtel

Eur J Cancer. 2022 Jan;161:128-137. doi: 10.1016/j.ejca.2021.10.033. Epub 2021 Dec 14.

ABSTRACT

AIM: Because the tyrosine kinases c-MET and vascular endothelial growth factor receptors (VEGFR) are often overexpressed in salivary gland cancer (SGC), this study evaluated the efficacy and safety of cabozantinib in patients with recurrent/metastatic (R/M) SGC.

PATIENTS AND METHODS: A single-centre phase II study was conducted. Patients with immunohistochemical c-MET-positive R/M SGC were included in three cohorts: adenoid cystic carcinoma (ACC); salivary duct carcinoma (SDC) and other miscellaneous SGCs. No prior systemic treatments were required. Patients started cabozantinib 60 mg once daily. The primary outcome was the objective response rate (ORR). Secondary outcomes included survival, safety and quality of life. Per Simon-two-stage design, depending on efficacy, a maximum of 43 patients would be included.

RESULTS: In total, 25 patients were included until premature closure owing to severe toxicity. Six patients (24%) had grade 3-5 wound complications, occurring at a median of 7.1 months on cabozantinib treatment (range 2.1-12.6). Remarkably, four of these six patients developed this complication in the area prior exposed to high-dose radiotherapy. Other grade ≥3 adverse events in >1 patient were hypertension (20%), diarrhoea (8%) and dehydration (8%). Twenty-one patients were evaluable for response; 1/15 ACC (ORR: 7%); 1/4 SDC and 0/2 patients with other miscellaneous SGC responded. Median progression-free survival was 9.4 months (95% confidence interval [CI] 7.4-11.4 months), 7.2 months (95%CI 0.0-15.1) and 6.9 months (95%CI 0.0-15.1), respectively.

CONCLUSION: This study showed too many severe cabozantinib-associated wound complications in patients with SGC, especially in prior irradiated areas. Therefore, the study closed prematurely. The efficacy in the limited number of evaluable patients was low to moderate.

TRIAL REGISTRATION: This trial was registered on ClinicalTrials.gov: NCT03729297.

PMID:34920917 | DOI:10.1016/j.ejca.2021.10.033
Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review

Fetched: December 18th, 2021, 5:00am GMT by Pierre Loap

Front Oncol. 2021 Nov 30;11:789079. doi: 10.3389/fonc.2021.789079. eCollection 2021.

ABSTRACT

Adenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from salivary glands. Radiation therapy can be employed as a single modality for unresectable tumors, in an adjuvant setting after uncomplete resection, in case of high-risk pathological features, or for recurrent tumors. Due to ACC intrinsic radioresistance, high linear energy transfer (LET) radiotherapy techniques have been evaluated for ACC irradiation: while fast neutron therapy has now been abandoned due to toxicity concerns, charged particle beams such as protons and carbon ions are at present the beams used for hadron therapy. Carbon ion radiation therapy (CIRT) is currently increasingly used for ACC irradiation. The aim of this review is to describe the immunological, molecular and clinicopathological bases that support ACC treatment with CIRT, as well as to expose the current clinical evidence that reveal the advantages of using CIRT for treating ACC.

PMID:34917512 | PMC:PMC8668942 | DOI:10.3389/fonc.2021.789079
Rare periorbital, pseudocystic metastasis of squamous cell carcinoma of the bladder: Case report and review of the literature

Fetched: December 17th, 2021, 5:00am GMT by Inga Neumann

Orbit. 2021 Dec 16:1-7. doi: 10.1080/01676830.2021.2012203. Online ahead of print.

ABSTRACT

We present the case of a man in his fifties with a history of bladder carcinoma who presented with a large periorbital cystic lesion that was found to be a metastasis. Bladder carcinomas are a very rare cause of peri-/orbital metastasis. The primary tumor in this case predominately showed squamous cell differentiation and small areas of adenoid differentiation. To our knowledge only one previous case of orbital metastasis from squamous cell carcinoma of the bladder has been reported. Cyst formation in bladder cancer metastasis has not been reported and is very rare for orbital metastases in general. The pathogenesis of metastatic cyst development is not fully understood and may vary from case to case. A biopsy of an atypical cyst is indicated.

PMID:34913824 | DOI:10.1080/01676830.2021.2012203
Indocyanine green fluorescent image-guided inguinal sentinel lymph node biopsy in vulvar cancer

Fetched: December 17th, 2021, 5:00am GMT by Young Hwa Kwak

Obstet Gynecol Sci. 2021 Dec 16. doi: 10.5468/ogs.21335. Online ahead of print.

ABSTRACT

OBJECTIVES: To demonstrate near-infrared fluorescence image-guided inguinal sentinel lymph node (SLN) biopsy in patients with vulvar cancer.

METHODS: A 40-year-old woman with a 3-cm-sized palpable left vulvar mass was diagnosed with vulvar cancer on biopsy with protrusion into the vaginal cavity. Pelvic contrast-enhanced magnetic resonance imaging and F-18 fluorodeoxyglucose positron-emission tomography-computed tomography showed a small ulcerative enhancing lesion confined to the left vulva without distant metastasis. The patient was scheduled for radical vulvectomy with a left inguinal SLN biopsy. ICG was injected directly into the vulvar mass to map lymphatic drainage. A 4-cm-sized linear incision was made on the left inguinal crease, and the lymphatic channels of the left inguinal area were dissected under fluorescent image guidance using a 1588 AIM Platform laparoscopic camera (Stryker).

RESULTS: Fluorescence image-guided left inguinal SLN biopsy was successfully performed, and radical vulvectomy was completed. The pathologic diagnosis confirmed vulvar adenoid cystic carcinoma with metastasis to the left inguinal lymph node (International Federation of Gynecology and Obstetrics stage IIIA). The patient was discharged without complications and received adjuvant radiotherapy.

CONCLUSIONS: This video demonstrates a successful ICG fluorescence image-guided left inguinal SLN biopsy in a vulvar cancer patient using a laparoscopic camera. Mapping of inguinal SLNs in patients with vulvar cancer may help in retaining surgical radicality while minimizing operative complications.

PMID:34911177 | DOI:10.5468/ogs.21335

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PubMed - Adenoid Cystic Carcinoma (34 unread)

Fetched: January 16th, 2022, 5:00am GMT by Jie Gao

Fetched: January 12th, 2022, 5:00am GMT by Mansooreh Jamshidian Tehrani

Fetched: January 12th, 2022, 5:00am GMT by Maria V Yusenko

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Fetched: January 5th, 2022, 5:00am GMT by Leandra Ernst Kerche

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Fetched: December 31st, 2021, 5:00am GMT by Edoardo Mastella

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Fetched: December 28th, 2021, 5:00am GMT by Tetsuro Morita

Fetched: December 28th, 2021, 5:00am GMT by Zhong-Qi Sun

Fetched: December 28th, 2021, 5:00am GMT by Qian Zhang

Fetched: December 25th, 2021, 5:00am GMT by Julia Schnoell

Fetched: December 25th, 2021, 5:00am GMT by Carlos A Rodriguez-Russo

Fetched: December 25th, 2021, 5:00am GMT by Asterios Triantafyllou

Fetched: December 24th, 2021, 5:00am GMT by Masanori Teshima

Fetched: December 23rd, 2021, 5:00am GMT by Aline Evangelista Santiago

Fetched: December 22nd, 2021, 5:00am GMT by Usha Rani

Fetched: December 22nd, 2021, 5:00am GMT by Mohammad A AlSemari

Fetched: December 21st, 2021, 5:00am GMT by Kevin Tyan

Fetched: December 21st, 2021, 5:00am GMT by Rajaguru Paramaguru

Fetched: December 19th, 2021, 5:00am GMT by Wim van Boxtel

Fetched: December 18th, 2021, 5:00am GMT by Pierre Loap

Fetched: December 17th, 2021, 5:00am GMT by Inga Neumann

Fetched: December 17th, 2021, 5:00am GMT by Young Hwa Kwak