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Google - Phyllodes Tumor
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Ki's Surgery Recovery Fund - Help! Love! Support!, organized by ... - GoFundMe
Posted: December 29th, 2022, 6:00am GMT
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Giant Malignant Phyllode Tumor: A Case Report - Cureus
Posted: December 27th, 2022, 6:00am GMT
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Breast cancer - Care at Mayo Clinic - Mayo Clinic News Network
Posted: December 14th, 2022, 6:00am GMT
Breast cancer - Care at Mayo Clinic Mayo Clinic News Network -
Rare case report on Hydatid cyst of breast | PLMI - Dove Medical Press
Posted: December 8th, 2022, 6:00am GMT
Rare case report on Hydatid cyst of breast | PLMI Dove Medical Press -
Can Children Get Breast Cancer? Childhood Risk Facts - Verywell Health
Posted: December 1st, 2022, 6:00am GMT
Can Children Get Breast Cancer? Childhood Risk Facts Verywell Health -
Imaging of the Pediatric Breast: Review of Normal Development and ... - RSNA Publications Online
Posted: November 25th, 2022, 6:00am GMT
Imaging of the Pediatric Breast: Review of Normal Development and ... RSNA Publications Online -
Immediate Deep Inferior Epigastric Perforator Flap Reconstruction of ... - Cureus
Posted: November 19th, 2022, 6:00am GMT
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Giant Phyllodes Tumor in an 82-Year-Old Female Initially ... - Cureus
Posted: November 17th, 2022, 6:00am GMT
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Primary Benign Phyllodes Tumour of the Labia Minora: An ... - Cureus
Posted: November 17th, 2022, 6:00am GMT
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Primary Malignant Peripheral Nerve Sheath Tumor of the Breast: A ... - Cureus
Posted: November 16th, 2022, 6:00am GMT
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Benign Breast Disease in Makkah, Saudi Arabia: A Retrospective ... - Cureus
Posted: November 6th, 2022, 5:00am GMT
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Finding a Lump in Your Breast—7 Possible Causes - Health.com
Posted: October 27th, 2022, 5:00am GMT
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October Tree of the Month: Shoestring Acacia - Santa Barbara Edhat
Posted: October 22nd, 2022, 5:00am GMT
October Tree of the Month: Shoestring Acacia Santa Barbara Edhat -
Benign vs. Malignant Tumors: Causes and Treatments - Verywell Health
Posted: October 17th, 2022, 5:00am GMT
Benign vs. Malignant Tumors: Causes and Treatments Verywell Health -
What Are the Different Types of Breast Cancer: Common, Rare ... - Katie Couric Media
Posted: September 26th, 2022, 5:00am GMT
What Are the Different Types of Breast Cancer: Common, Rare ... Katie Couric Media -
Phyllodes Tumor: Types, Symptoms, Causes, Treatments - Healthgrades
Posted: September 9th, 2022, 5:00am GMT
Phyllodes Tumor: Types, Symptoms, Causes, Treatments Healthgrades -
Phyllodes Breast Cancer Tumor: Definition, Survival Rate, and More - Verywell Health
Posted: August 16th, 2022, 5:00am GMT
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Bilateral Phyllodes in a 12-Year-Old Adolescent: Report of a Rare ... - Cureus
Posted: August 1st, 2022, 5:00am GMT
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Descriptive epidemiology of soft tissue sarcomas and ... - Nature.com
Posted: July 27th, 2022, 5:00am GMT
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Breast Lesions: Causes, Diagnosis, Treatment, and More - Healthline
Posted: July 14th, 2022, 5:00am GMT
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Multi-omics study identifies novel signatures of DNA/RNA, amino ... - Nature.com
Posted: July 14th, 2022, 5:00am GMT
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Mosses in the Kopački Rit Nature Park, Croatia, as bioindicators of a ... - Nature.com
Posted: July 8th, 2022, 5:00am GMT
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Identification and Management of Pathogenic Variants in BRCA1 ... - Cancer Discovery
Posted: June 1st, 2022, 6:54am GMT
Identification and Management of Pathogenic Variants in BRCA1 ... Cancer Discovery -
Development of an intraoperative breast cancer margin assessment ... - Nature.com
Posted: May 20th, 2022, 5:00am GMT
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ACS Case Reviews in Surgery Volume 2, Number 5 Table of ... - American College of Surgeons
Posted: May 2nd, 2022, 10:21pm GMT
ACS Case Reviews in Surgery Volume 2, Number 5 Table of ... American College of Surgeons -
Abdominal Pain: The Double Trouble!!! | ACS - American College of Surgeons
Posted: May 1st, 2022, 8:28pm GMT
Abdominal Pain: The Double Trouble!!! | ACS American College of Surgeons -
An Unusual Case of Fibromatosis of the Breast with Numerous ... - American College of Surgeons
Posted: May 1st, 2022, 8:18pm GMT
An Unusual Case of Fibromatosis of the Breast with Numerous ... American College of Surgeons -
Plant of the Month – Acacia Sophorae – Coastal Wattle - Rainbow Beach Cooloola Coast Community News
Posted: April 19th, 2022, 5:00am GMT
Plant of the Month – Acacia Sophorae – Coastal Wattle Rainbow Beach Cooloola Coast Community News -
Early Breast Cancer Signs: Symptoms and Types of Breast Cancers - Good Housekeeping
Posted: March 7th, 2022, 6:00am GMT
Early Breast Cancer Signs: Symptoms and Types of Breast Cancers Good Housekeeping -
Efficacy of Modified Masood Scoring System (MMSS) in Cytological ... - Cureus
Posted: February 16th, 2022, 6:00am GMT
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Breast Cancer: Symptoms, Causes, Treatment and More - Health Central
Posted: October 4th, 2021, 5:00am GMT
Breast Cancer: Symptoms, Causes, Treatment and More Health Central -
National breast screening pathology audit - GOV.UK
Posted: September 21st, 2021, 5:00am GMT
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Climate Change Is Killing Trees, and They're Toppling Onto Power ... - KQED
Posted: September 21st, 2021, 5:00am GMT
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MedStar Southern Maryland Hospital Center Welcomes MedStar ... - Bay Net
Posted: September 14th, 2021, 5:00am GMT
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Atypical Ductal Hyperplasia: Breast Cancer Risk and More - Healthline
Posted: April 29th, 2021, 5:00am GMT
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How Swig is honoring Breast Cancer Awareness Month - ABC4.com
Posted: October 1st, 2020, 5:00am GMT
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Wattle It Be - Gardening Australia - ABC News
Posted: September 4th, 2020, 5:00am GMT
Wattle It Be - Gardening Australia ABC News -
The World's Most Interesting Insects | Science - Smithsonian Magazine
Posted: April 29th, 2020, 5:00am GMT
The World's Most Interesting Insects | Science Smithsonian Magazine -
Lump on breast: Types, diagnosis, and other symptoms - Medical News Today
Posted: February 13th, 2020, 8:18pm GMT
Lump on breast: Types, diagnosis, and other symptoms Medical News Today -
Breast cancer symptoms: Early signs, pictures, and more - Medical News Today
Posted: February 13th, 2020, 4:52pm GMT
Breast cancer symptoms: Early signs, pictures, and more Medical News Today -
Breast Lump or Mass as a Symptom of Cancer | News - Breast Cancer News
Posted: April 6th, 2016, 12:05pm GMT
Breast Lump or Mass as a Symptom of Cancer | News Breast Cancer News -
Teasing Out The Differences Between Breast Fibroepithelial Tumors - Asian Scientist Magazine
Posted: October 15th, 2015, 5:00am GMT
Teasing Out The Differences Between Breast Fibroepithelial Tumors Asian Scientist Magazine -
Capitals Attend Ohio Funeral of Andi Lambert, Wife of Assistant ... - Russian Machine Never Breaks
Posted: September 27th, 2015, 5:00am GMT
Capitals Attend Ohio Funeral of Andi Lambert, Wife of Assistant ... Russian Machine Never Breaks -
Frozen treatment: Rockwood's IceCure machine can solve benign ... - The Spokesman Review
Posted: August 25th, 2015, 5:00am GMT
Frozen treatment: Rockwood's IceCure machine can solve benign ... The Spokesman Review -
Caterpillar an expert in mimicry - Australian Geographic - Australian Geographic
Posted: April 17th, 2014, 5:00am GMT
Caterpillar an expert in mimicry - Australian Geographic Australian Geographic
PubMed - Phyllodes Tumor
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Transformation of a Benign-Appearing Fibroepithelial Lesion to a Giant Malignant Phyllodes Tumor of the Breast
Fetched: January 27th, 2023, 5:02am GMT by Eve G Paxton
Cureus. 2022 Dec 23;14(12):e32881. doi: 10.7759/cureus.32881. eCollection 2022 Dec.
ABSTRACT
This is a case of a woman who presented with a left breast mass that was initially diagnosed as fibroadenoma on core biopsy and, after three years without any surgical intervention, was found to be a malignant phyllodes tumor. Initially, a core needle biopsy of the mass showed probable fibroadenoma. Because of the initial benign seeming diagnosis and the need to treat her tongue cancer, the patient did not recognize the need for a recommended surgical consultation and excision. Three years later, she presented after the mass had enlarged to encompass nearly the whole left breast. Core needle biopsy revealed spindle cell proliferation with scattered benign-looking tubules. Due to the large size of the mass, she underwent a total mastectomy, and the final pathology demonstrated a malignant phyllodes tumor. This case demonstrates a case of progression of a benign-appearing fibroepithelial lesion to a malignant phyllodes tumor three years later.
PMID:36699789 | PMC:PMC9867914 | DOI:10.7759/cureus.32881
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ASO Visual Abstract: Margin Status and Local Recurrence in Phyllodes Tumors of the Breast-A Canadian Series
Fetched: January 22nd, 2023, 5:02am GMT by Dan Moldoveanu
Ann Surg Oncol. 2023 Jan 20. doi: 10.1245/s10434-022-12987-y. Online ahead of print.
NO ABSTRACT
PMID:36670277 | DOI:10.1245/s10434-022-12987-y
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Efficacy and safety of percutaneous ultrasound-guided vacuum-assisted excision for the treatment of clinical benign breast lesions larger than 3 cm: a retrospective cohort study
Fetched: January 21st, 2023, 5:01am GMT by Bo Wang
Ann Transl Med. 2022 Dec;10(24):1345. doi: 10.21037/atm-22-5829.
ABSTRACT
BACKGROUND: Breast ultrasound-guided vacuum-assisted excision (US-VAE) has become a scarless solution for the removal of benign breast lesions. This procedure is now favored by more and more female patients for its satisfactory cosmetic outcome and few postoperative complications. However, controversy have been raised regarding its efficacy and safety in treating larger benign breast lesions. This study aimed to evaluate whether US-VAE is sufficient for the treatment of clinical benign breast lesions larger than 3 cm and to investigate the lesion features that affect the complete excision rate and hematoma occurrence rate.
METHODS: From January 2018 to July 2021, a total of 1,812 lesions in 1,367 patients underwent US-VAE at the Chinese People's Liberation Army General Hospital. A total of 89 benign breast lesions in 87 patients enrolled in this retrospective cohort study. The baseline clinical characteristics and ultrasonographic features of the lesions were recorded. Patients were followed up by US to record if there are any serious issues and the occurrence of hematoma and the recurrence of the lesions within 3 days and 6-12 months later, then at 1-year intervals. Lesions were classified to analyze the possible factors associated with complete excision rate and hematoma occurrence rate.
RESULTS: The mean age was 35.9±9.5 years (range, 18-54 years), and the median maximum size of benign breast lesions was 3.5 cm (range, 3.1-5.0 cm). The complete excision rate was 91.0% (81/89). Histopathology (P=0.002) and vascularity (P=0.032) of lesions showed statistically significant differences in groups with or without recurrent lesions. A total of 17 cases (17/89, 19.1%) presented with hematoma after the procedure. The maximum lesion size in patients with hematoma was significantly larger than that in those without hematoma (P<0.001).
CONCLUSIONS: US-VAE is an effective and safe alternative method for the treatment of benign breast lesions larger than 3 cm, especially for fibroadenoma, adenosis, hamartoma. For benign phyllodes tumors and intraductal papillomas larger than 3 cm and lesions with hypervascularity, the possibility of recurrence after US-VAE should be noted. The size of lesions needs to be considered when evaluating the occurrence of hematoma after US-VAE.
PMID:36660716 | PMC:PMC9843416 | DOI:10.21037/atm-22-5829
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A rare case of metastatic malignant phyllodes tumor with osteosarcomatous differentiation presenting with intestinal obstruction
Fetched: January 20th, 2023, 5:02am GMT by Neelam R Bhandari
Indian J Pathol Microbiol. 2023 Jan-Mar;66(1):184-187. doi: 10.4103/ijpm.ijpm_379_21.
ABSTRACT
Phyllodes tumors (PTs) are uncommon biphasic breast neoplasms constituting 0.5 to 1.0% of all breast tumors. Malignant PTs form a very small proportion of these and may metastasize, especially to the lungs and bones. Aggression and metastatic potential are accentuated in tumors exhibiting heterologous differentiation. Metastases to the gastrointestinal tract (GIT) have seldom been reported and are often confined to a segment of the digestive tract. In the absence of relevant clinical history, such patients presenting with gastrointestinal symptoms can lead to diagnostic perplexities. We report a unique case of a malignant PT with extensive osteosarcomatous differentiation and widespread metastases to the GIT.
PMID:36656238 | DOI:10.4103/ijpm.ijpm_379_21
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Surgery for phyllodes tumour of the breast. What should be surgical margins?
Fetched: January 12th, 2023, 5:02am GMT by Mustafa Tukenmez
ANZ J Surg. 2023 Jan 11. doi: 10.1111/ans.18264. Online ahead of print.
ABSTRACT
BACKGROUNDS: Optimal and tailored surgical treatment of phyllodes tumour(PT) of the breast is controversial. This study aims to determine the appropriate surgical margin in the treatment of PT.
METHODOLOGY: The data of 132 patients who underwent breast surgery with the diagnosis of PT at the Breast Unit of Istanbul Faculty of Medicine from 2000 to 2022 were retrospectively reviewed.
RESULTS: Median age was 38 and patients with benign PT were younger than others(median age was 34, 44, and 43 for benign, borderline, and malignant, respectively) (P = 0.001). Local recurrence was observed in 7 (5.3%) patients, systemic recurrence was observed in 3 (2.3%) patients, and disease-related death was observed in 2 (1.5%) patients. Local recurrence occurred in 1.4% (n = 1) of benign tumours, 8.3% (n = 2) of borderline tumours, and 10.3% (n = 4) of malignant tumours. All of the systemic recurrences and deaths were seen in the malignant group. The local recurrence rate was found to be higher in borderline and malignant tumours with surgical margins less than 10 mm (44.4% versus 3.7%, P = 0.003), and tumours larger than 5 cm (11.8% versus 1.3%, P = 0.015). In comparison, there was no correlation between the surgical margin proximity, tumour diameter, and local recurrence rates in benign PT (P > 0.05).
CONCLUSION: According to our findings, negative surgical margins seem to be sufficient in the treatment of benign phyllodes tumours. Furthermore at least 1 cm negative surgical margins must be achieved for malignant and borderline phyllodes tumours to avoid local recurrence.
PMID:36629354 | DOI:10.1111/ans.18264
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"Growing fibroadenoma": Are there clinical and pathological features predicting a phyllodes tumor on surgical excision?
Fetched: January 4th, 2023, 5:03am GMT by Gahie Nam
Ann Diagn Pathol. 2023 Feb;62:152069. doi: 10.1016/j.anndiagpath.2022.152069. Epub 2022 Nov 22.
ABSTRACT
In cases of growth of FA on imaging, core needle biopsies (CNB) are often performed to rule out phyllodes tumor (PT). We aim to focus on "growing FAs" and to identify clinical and histopathologic features that are likely to predict a PT on excision. Thirty-four FAs with radiologic documentation of growth were included. Various clinical and pathological features such as age, body mass index (BMI), lesion size, and growth rate were recorded. On excision, 17 cases (50 %) were FAs, whereas 16 (47 %) were re-classified as benign PT despite only 19 % being suspicious for PT on CNB. PT patients were older (mean age 42.6) than those with FAs (mean age 28.2), p = 0.0002. All false negative cases demonstrated intracanalicular growth. Mitotic rate was the most significant histologic feature in PT on excision compared to others, such as lesion circumscription and stromal cellularity. Recognition and careful counting of mitotic rate, especially with intracanalicular patterns in growing FAs, can potentially prevent missing a PT on CNB. In patients with "growing FAs" who are ≥40 years of age, excision may be recommended due to the high likelihood of PT diagnosis on excision and high false negative rate on CNB.
PMID:36527840 | DOI:10.1016/j.anndiagpath.2022.152069
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Recurrence is Not Associated with Margin Status in Phyllodes Tumor
Fetched: January 4th, 2023, 5:02am GMT by Kyung-Hwak Yoon
Ann Surg Oncol. 2023 Jan 3. doi: 10.1245/s10434-022-12997-w. Online ahead of print.
ABSTRACT
BACKGROUND: Phyllodes tumor (PT) is a rare fibroepithelial neoplasm of the breast. The proper extent of resection is still under debate. This study aimed to investigate the optimal surgical margin to prevent recurrence after surgery for PT and to evaluate risk factors for local recurrence (LR).
METHODS: Retrospective analysis of a prospective cohort database was performed. Patients who underwent curative surgery for PT at Seoul National University Bundang Hospital between July 2003 and February 2022 were reviewed.
RESULTS: Of the 439 patients included, 285 were benign, 129 were borderline, and 25 were malignant. There was no statistically significant difference in 5-year disease-free survival (DFS) between margin-negative and margin-involved patients (87.3% vs. 85.1%, p = 0.081). When patients were classified into groups, according to margin status, as conventional (≥ 1 cm from tumor), close (< 1 cm from tumor), or involved, 5-year DFS rates were also similar (100% vs. 86.9% vs. 85.1%, p = 0.170). In subgroup analysis for different histologic grades, 5-year DFS was not affected by margin involvement. In univariate analysis, large tumor size (> 5 cm; hazard ratio [HR] 2.857, p = 0.028) and infiltrative tumor border (HR 3.096, p = 0.012) were independent risk factors for LR. Further multivariate analysis found both factors to be prognostic.
CONCLUSIONS: Recurrence was not significantly influenced by margin status in all histological grades. In benign and borderline tumors, local excision without wide surgical margins could be sufficient, and watchful waiting could be an option for patients with positive margins after initial surgery.
PMID:36596955 | DOI:10.1245/s10434-022-12997-w
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Histological Risk Factors for Local Recurrence of Phyllodes Tumors of the Breast
Fetched: January 1st, 2023, 5:01am GMT by Camille Mimoun
Anticancer Res. 2023 Jan;43(1):143-147. doi: 10.21873/anticanres.16143.
ABSTRACT
BACKGROUND/AIM: The rate of local recurrence (LR) of phyllodes tumor (PT) varies from 4 to 18%. Several histological risk factors of LR of PT are known. The aim of this study was to estimate the LR rate of PT according to PT grade and to evaluate histological risk factors of PT LR in our retrospective cohort.
PATIENTS AND METHODS: This was a two-center study, conducted from 1995 to 2019. All patients with PT diagnosed on surgical specimen were included. PT was diagnosed histologically according to the grade category defined by the 2012 World Health Organization classification as benign, borderline or malignant PT. Univariate analysis and then multivariate logistic regression analysis were performed to determine histological risk factors of LR of PT.
RESULTS: A total of 224 patients with PT were included: 152 with benign, 49 with borderline and 23 with malignant PT. The median and standard deviation for the duration of follow-up was 136.60 ± 167.43 months, and 18 patients (8.04%) developed LR: 7 (4.61%), 7 and (14.29%) and 4 (17.39%) with benign, borderline and malignant PT, respectively. In univariate analysis, LR was statistically increased for histological size ≥45 mm (p=0.003), borderline/malignant TP (p=0.006) and dense stromal cellularity (p<0.001). In multivariate analysis, only histological size ≥45 mm and cellularity were statistically associated with LR (odds ratio=1.83, 95% confidence interval=1.06-9.83, p=0.04; and odds ratio=3.69, 95% confidence interval=1.11-12.28, p=0.03, respectively).
CONCLUSION: Histological size ≥45 mm and dense stromal cellularity were demonstrated as histological risk factors of LR of PT. In our cohort, no association was found between LR and PT grade nor LR and surgical margins ≥10 mm.
PMID:36585183 | DOI:10.21873/anticanres.16143
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Phyllodes tumour evidence gaps mapped from the 5th edition of the WHO classification of tumours of the breast
Fetched: December 30th, 2022, 5:03am GMT by Nur Diyana Md Nasir
Histopathology. 2022 Dec 28. doi: 10.1111/his.14856. Online ahead of print.
ABSTRACT
AIMS: Breast phyllodes tumours (PT) are a rare subset of fibroepithelial neoplasms categorised into benign, borderline, and malignant grades according to the World Health Organization (WHO) Classification of Tumours (WCTs). In this report, we developed an evidence gap map (EGM) based on literature cited in the PT chapter of the 5th edition of the breast WCT in order to identify knowledge and research gaps in PT.
METHODS: A framework was first established where the dimensions of the EGM were defined as categories of tumour descriptors, tumour types and evidence levels. Citations were collected into a Microsoft Excel® form and imported into EPPI-reviewer to produce the EGM.
RESULTS: The EGM showed that "Histopathology" and "Pathogenesis" sections contained the most citations, the majority being of low-level evidence. The highest number of citations considered of moderate-level evidence were found in the "Histopathology" section. There was no high-level evidence cited in this chapter. "Localization", "Etiology" and "Staging" sections had the fewest citations.
CONCLUSIONS: This EGM provides a visual representation of cited literature in the PT chapter of the breast WCT, revealing the lack of high-level evidence citations. There is an uneven distribution of references, probably due to citation practices. Pockets of low-level evidence are highlighted, possibly related to referencing habits, lack of relevant research, or belief that the information presented is standard accepted fact without need for specific citations. Future work needs to bridge evidence gaps and broaden citations beyond those in the latest WCT.
PMID:36579383 | DOI:10.1111/his.14856
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Fibroadenoma of the breast; incidence of malignancy and indicators for surgical intervention: An analysis of 1392 patients
Fetched: December 25th, 2022, 5:02am GMT by Waleed Elnahas
Breast Dis. 2022;41(1):421-426. doi: 10.3233/BD-210074.
ABSTRACT
BACKGROUND: Fibroadenomas are common among young females. The size of the lesion used to be an indication for further assessment or excision. With arising of the watch and see proponents, criteria for selecting patients are important to establish.
METHODS: This is a retrospective study of a prospectively maintained database where all patients having the clinical/radiological provisional diagnosis of fibroadenoma and attending our center - from January 2008 to March 2020 - were enrolled. The primary outcome was the incidence of malignancy and the secondary outcomes were the correlation of malignancy-risk with epidemiologic and radiologic criteria.
RESULTS: The study enrolled 1392 patients. The mean age of the patients was 35.7 + ∕- 13.1 years. The median of the longest diameter of the detected breast lesions was 25 mm. The incidence of malignancy was 188 (13.5%). The size of the lesion measured by largest diameter was insignificant (p = 0.99), while the patients' age, marital status, and imaging criteria as measured by BIRADS score were significant (<0.001).
CONCLUSION: Approaching patients with the age above 35 or with BIRADS 4 provisionally diagnosed with fibroadenomas should be cautious with biopsy and short-term follow-ups The size of the tumor alone should not be used as an indication for surgical intervention.
PMID:36565097 | DOI:10.3233/BD-210074
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Ureteral tumor with morphological features analogous to phyllodes tumor: a unique case with concomitant urothelial carcinoma
Fetched: December 25th, 2022, 5:02am GMT by Wei Zhou
Diagn Pathol. 2022 Dec 23;17(1):94. doi: 10.1186/s13000-022-01277-6.
ABSTRACT
BACKGROUND: Phyllodes tumors belong to a spectrum of biphasic fibroepithelial lesions and are most commonly found in the breast. They are extremely rare in the urinary tract and only one case of bladder phyllodes tumor has been reported.
CASE PRESENTATION: We present a 69-year-old man with gross hematuria without an apparent cause. Computed tomography-urography and cystoscopic examination revealed a 5 × 4 cm lesion in the right ureteral orifice. He underwent a laparoscopic nephroureterectomy and partial cystectomy. Postoperative pathology confirmed a leaf-like structure consisting of myxoid stroma and peripheral urothelium. Stromal cells were spindle-shaped and stellate in appearance with no conspicuous cytological atypia or mitosis. The outlining urothelium had varying degrees of dysplasia, while in areas with moderate-to-severe dysplasia, active mitotic activity, abnormal giant cells, and focal early infiltration were observed. Overall, this case had the morphological features of benign phyllodes tumors and concomitant invasive urothelial carcinoma inside. The patient remained disease-free at 7 months after surgery.
CONCLUSION: We report the first ureteral tumor with the morphological characteristics of a phyllodes tumor and concomitant invasive urothelial carcinoma inside. Considering the potential for local recurrence of phyllodes tumors and invasive urothelial carcinoma, long-term clinical and radiological follow-up of such lesions are advisable.
PMID:36564794 | PMC:PMC9784280 | DOI:10.1186/s13000-022-01277-6
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Immediate Deep Inferior Epigastric Perforator Flap Reconstruction of a Giant Phyllodes Tumor
Fetched: December 24th, 2022, 5:02am GMT by Brandon Larson
Cureus. 2022 Nov 19;14(11):e31685. doi: 10.7759/cureus.31685. eCollection 2022 Nov.
ABSTRACT
We present a case of a giant phyllodes tumor (PT) requiring simple mastectomy with en bloc pectoralis major resection and immediate deep inferior epigastric perforator (DIEP) flap reconstruction. This patient presented with a four-year history of an enlarging breast mass with ultrasound-guided biopsy results consistent with atypical fibroepithelial proliferation that was highly concerning for a borderline phyllodes tumor. In this large, rare breast tumor that required en bloc pectoralis major resection, we describe the novel use of an immediate single pedicled DIEP flap for the resulting chest wall defect. The patient's postoperative course was uncomplicated, and she reported satisfactory cosmetic and functional outcomes at her initial postoperative follow-up visits. Our findings support the use of simple mastectomy with en bloc resection and immediate single-pedicled DIEP flap for the definitive treatment of giant phyllodes tumors. Our experience shows this is a safe and effective technique for achieving adequate oncologic resection while maintaining postoperative function and cosmesis, which are essential for patient quality of life.
PMID:36561588 | PMC:PMC9767667 | DOI:10.7759/cureus.31685
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Nodular Fasciitis of the Breast Mimicking Phyllodes Tumors: A Case Report and Literature Review
Fetched: December 23rd, 2022, 5:02am GMT by Yun Hwa Chang
J Korean Soc Radiol. 2022 Nov;83(6):1394-1399. doi: 10.3348/jksr.2022.0028. Epub 2022 Nov 10.
ABSTRACT
Nodular fasciitis is a benign proliferative lesion of the fibroblasts and/or myofibroblasts, generally detected in the soft tissue of the upper extremities. It has also been reported in the lower extremities, head, and neck, and rarely in the breast. Its rarity and nonspecific clinical and radiological features resemble those of malignant tumors of the breast and make the differential diagnosis and management difficult. Herein, we present a rare case of nodular fasciitis of the breast, which was initially suspected to be a phyllodes tumor.
PMID:36545411 | PMC:PMC9748462 | DOI:10.3348/jksr.2022.0028
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Giant Phyllodes Tumor in an 82-Year-Old Female Initially Diagnosed a Fibroadenoma: A Case Report
Fetched: December 22nd, 2022, 5:02am GMT by Donald Hefelfinger
Cureus. 2022 Nov 17;14(11):e31598. doi: 10.7759/cureus.31598. eCollection 2022 Nov.
ABSTRACT
Phyllodes tumors are a rare fibroepithelial neoplasm of the breast occurring in approximately 2.1 in every 1 million women with no clear predilection for women of specific races. They are characterized by spindle-shaped stromal cells with increased stromal cellularity and increased mitotic activity. The histologic characteristics are similar to that of cellular fibroadenomas making them frequently difficult to differentiate on core biopsy. We present a case of an 82-year-old female with a right breast mass which was initially diagnosed as a fibroadenoma in 2009. She was lost to follow-up and presented in 2021 with complaint of a right breast mass for which diagnostic imaging was performed. A diagnostic mammogram demonstrated a macrolobulated mass measuring 14×12×12 cm which corresponded to the palpable abnormality. The patient subsequently underwent simple mastectomy demonstrating a 14 cm mass with a fibroepithelial structure consistent with a borderline phyllodes tumor. The patient received adjuvant radiotherapy to minimize the likelihood of local recurrence. We concluded that reliable preoperative diagnosis and further studies regarding guidelines for adequate tumor margins and indication for adjuvant radiotherapy are crucial for proper surgical planning and follow-up after excision.
PMID:36540540 | PMC:PMC9758957 | DOI:10.7759/cureus.31598
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Primary Benign Phyllodes Tumour of the Labia Minora: An Uncommon Entity
Fetched: December 22nd, 2022, 5:02am GMT by Harrypal Panesar
Cureus. 2022 Nov 17;14(11):e31616. doi: 10.7759/cureus.31616. eCollection 2022 Nov.
ABSTRACT
A phyllodes tumour of the vulva is a rare, well-illustrated benign neoplasm having characteristic histo-morphological features similar to a phyllodes tumour of the breast. We report a case of a primary benign phyllodes tumour in a 28-year-old female patient. She was seen in an outpatient clinic presenting with a slow-growing, non-painful lesion on her vulva. Examination revealed a 2 cm cyst located on the labia minora. Complete excision of the cyst was achieved, and pathological examination revealed a benign phyllodes tumour of the vulva. Hallmarks of this rare pathology are classically a leaf-like architectural configuration and fronds projecting into the cystic spaces on a low-power magnification. To date, a grading or classification of these vulva tumours has not been established due to their rarity. There have been very few reported cases of phyllodes tumours occurring on the vulva and fewer still affecting the labia minora. Continued surveillance for recurrence should be adopted.
PMID:36540437 | PMC:PMC9759321 | DOI:10.7759/cureus.31616
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An integrative approach for exploring the nature of fibroepithelial neoplasms
Fetched: December 16th, 2022, 5:01am GMT by Jihui Yun
Br J Cancer. 2022 Dec 16. doi: 10.1038/s41416-022-02064-2. Online ahead of print.
ABSTRACT
BACKGROUND: Malignant phyllodes tumour (MPT) is a rare breast malignancy with epithelial and mesenchymal features. Currently, there are no appropriate research models or effective targeted therapeutic approaches for MPT.
METHODS: We collected fresh frozen tissues from nine patients with MPT and performed whole-exome and RNA sequencing. Additionally, we established patient-derived xenograft (PDX) models from patients with MPT and tested the efficacy of targeting dysregulated pathways in MPT using the PDX model from one MPT.
RESULTS: MPT has unique molecular characteristics when compared to breast cancers of epithelial origin and can be classified into two groups. The PDX model derived from one patient with MPT showed that the mouse epithelial component increased during tumour growth. Moreover, targeted inhibition of platelet-derived growth factor receptor (PDGFR) and phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) by imatinib mesylate and PKI-587 showed in vivo tumour suppression effects.
CONCLUSIONS: This study revealed the molecular profiles of MPT that can lead to molecular classification and potential targeted therapy, and suggested that the MPT PDX model can be a useful tool for studying the pathogenesis of fibroepithelial neoplasms and for preclinical drug screening to find new therapeutic strategies for MPT.
PMID:36522480 | DOI:10.1038/s41416-022-02064-2