Conditions: Breast Disease; Phyllodes Breast Tumor
Intervention: Procedure: cryotherapy
Sponsor: KK Women's and Children's Hospital
Recruiting
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Rhabdomyosarcoma
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Sarcoma
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Phyllodes (105 unread)
Trial - Phyllodes
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Cryotherapy in Breast B3 Lesions
Posted: October 1st, 2020, 2:00pm GMT
Google - Phyllodes Tumor
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MedStar Southern Maryland Hospital Center Welcomes MedStar Health Breast Surgeon - Bay Net
Posted: September 14th, 2021, 10:30am GMT
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MedStar Southern Maryland Hospital Center welcomes MedStar Health breast surgeon Patricia Wehner to the team - The Southern Maryland Chronicle
Posted: September 13th, 2021, 4:00pm GMT
MedStar Southern Maryland Hospital Center welcomes MedStar Health breast surgeon Patricia Wehner to the team The Southern Maryland Chronicle -
What You Need To Know Now If You DO Find A Lump In Your Breast - Todayuknews - Todayuknews
Posted: September 6th, 2021, 7:36pm GMT
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Benign Breast Conditions - Breastcancer.org
Posted: August 18th, 2021, 5:00am GMT
Benign Breast Conditions Breastcancer.org -
The many different kinds of wattles - The Transcontinental
Posted: August 13th, 2021, 5:00am GMT
The many different kinds of wattles The Transcontinental -
The many different kinds of wattles - Illawarra Mercury
Posted: August 13th, 2021, 5:00am GMT
The many different kinds of wattles Illawarra Mercury -
The many different kinds of wattles - The Advocate
Posted: August 12th, 2021, 6:00pm GMT
The many different kinds of wattles The Advocate -
The many different kinds of wattles - Illawarra Mercury
Posted: August 12th, 2021, 6:00pm GMT
The many different kinds of wattles Illawarra Mercury -
The many different kinds of wattles - The Islander
Posted: August 12th, 2021, 6:00pm GMT
The many different kinds of wattles The Islander -
The many different kinds of wattles - Tasmania Examiner
Posted: August 12th, 2021, 6:00pm GMT
The many different kinds of wattles Tasmania Examiner -
The many different kinds of wattles - The Canberra Times
Posted: August 12th, 2021, 6:00pm GMT
The many different kinds of wattles The Canberra Times -
Breast Cancer: Overview and the Effect on Black Women - Verywell Health
Posted: August 9th, 2021, 8:14pm GMT
Breast Cancer: Overview and the Effect on Black Women Verywell Health -
Ovarian cancer: Potential therapeutic target identified - California News Times
Posted: August 5th, 2021, 6:46pm GMT
Ovarian cancer: Potential therapeutic target identified California News Times -
'I have a confession to make': One couple's roller-coaster ride on the NFL fringe - The Athletic
Posted: August 4th, 2021, 9:03am GMT
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Down in the Garden: How to Create a Fragrant Native Garden - Central Coast Community News
Posted: March 19th, 2021, 5:00am GMT
Down in the Garden: How to Create a Fragrant Native Garden Central Coast Community News -
Advanced Breast Cancer: Treatments, Support, and How You'll Feel - WebMD
Posted: February 8th, 2021, 6:00am GMT
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Type 2 Diabetes Drug Metformin Could Help Prevent Some Breast Cancers - WebMD
Posted: February 1st, 2021, 6:00am GMT
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Surgery for Phyllodes Breast Tumors Varies Widely - MedPage Today
Posted: December 17th, 2020, 6:00am GMT
Surgery for Phyllodes Breast Tumors Varies Widely MedPage Today -
National breast screening pathology audit - GOV.UK
Posted: December 8th, 2020, 6:00am GMT
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What Is the Newest Treatment for Breast Cancer? - MedicineNet
Posted: November 10th, 2020, 6:00am GMT
What Is the Newest Treatment for Breast Cancer? MedicineNet -
The Impact of the COVID‐19 Pandemic on Surgical Management of Breast Cancer: Global Trends and Future Perspectives - The Oncologist
Posted: October 21st, 2020, 5:00am GMT
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Popular Drink Shop, Swig, Launches Breast Cancer Fundraising Campaign "Save the Cups" - PRNewswire
Posted: October 5th, 2020, 5:00am GMT
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How Swig is honoring Breast Cancer Awareness Month - ABC 4
Posted: October 1st, 2020, 5:00am GMT
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Wattle It Be - Fact Sheets - Gardening Australia - GARDENING AUSTRALIA - ABC News
Posted: September 4th, 2020, 5:00am GMT
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GARDENING | Wattle you plant in your garden this spring - The Canberra Times
Posted: August 28th, 2020, 5:00am GMT
GARDENING | Wattle you plant in your garden this spring The Canberra Times -
GARDENING | Wattle you plant in your garden this spring - Armidale Express
Posted: August 28th, 2020, 5:00am GMT
GARDENING | Wattle you plant in your garden this spring Armidale Express -
Wattle, a little ray of winter sunshine - Sydney Morning Herald
Posted: August 7th, 2020, 5:00am GMT
Wattle, a little ray of winter sunshine Sydney Morning Herald -
What Are the Four Types of Breast Cancer? - MedicineNet
Posted: August 6th, 2020, 5:00am GMT
What Are the Four Types of Breast Cancer? MedicineNet -
After 67 years, Basilan’s violin beetle now in scientific documents - INQUIRER.net
Posted: June 30th, 2020, 5:00am GMT
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XAF1 as a modifier of p53 function and cancer susceptibility - Science Advances
Posted: June 24th, 2020, 5:00am GMT
XAF1 as a modifier of p53 function and cancer susceptibility Science Advances -
XAF1 as a modifier of p53 function and cancer susceptibility - Science Advances
Posted: June 24th, 2020, 5:00am GMT
XAF1 as a modifier of p53 function and cancer susceptibility Science Advances -
A touch of light: Dead finish and friends - Alice Springs News Online
Posted: June 23rd, 2020, 5:00am GMT
A touch of light: Dead finish and friends Alice Springs News Online -
Blood Test Could Spot Breast Cancer Early - WebMD
Posted: June 10th, 2020, 5:00am GMT
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Breast Cancer: Symptoms, Risk Factors, Diagnosis, Treatment & Prevention - WebMD
Posted: June 8th, 2020, 5:00am GMT
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The World's Most Interesting Insects | Science - Smithsonian.com
Posted: April 29th, 2020, 5:00am GMT
The World's Most Interesting Insects | Science Smithsonian.com -
Delayed treatment, risk of infection and more: How cancer, dialysis patients are dealing with challenges amid coronavirus crisis - The Indian Express
Posted: April 24th, 2020, 5:00am GMT
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Breast cancer symptoms: Early signs, pictures, and more - Medical News Today
Posted: January 14th, 2020, 6:00am GMT
Breast cancer symptoms: Early signs, pictures, and more Medical News Today -
Kaplan USMLE Step 2 prep: Diagnosis of a breast lump - American Medical Association
Posted: January 13th, 2020, 6:00am GMT
Kaplan USMLE Step 2 prep: Diagnosis of a breast lump American Medical Association -
Enteritis with immune checkpoint inhibitor use - CMAJ
Posted: October 7th, 2019, 5:00am GMT
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Bay Bonsai Show and Demonstrations at Port Stephens Community Arts Centre - News Of The Area
Posted: October 1st, 2019, 5:00am GMT
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Small cell vs. non-small cell lung cancer: What are the differences? - Medical News Today
Posted: September 5th, 2019, 5:00am GMT
Small cell vs. non-small cell lung cancer: What are the differences? Medical News Today -
Phyllodes tumors: Symptoms, diagnosis, and treatment - Medical News Today
Posted: August 19th, 2019, 5:00am GMT
Phyllodes tumors: Symptoms, diagnosis, and treatment Medical News Today -
Follow Up Care For Phyllodes Tumors - News-Medical.net
Posted: August 13th, 2019, 5:00am GMT
Follow Up Care For Phyllodes Tumors News-Medical.net -
The mighty mulga grows deep and lives long - The Conversation AU
Posted: June 21st, 2019, 5:00am GMT
The mighty mulga grows deep and lives long The Conversation AU -
Mammography and MRI manifestations of breast angiosarcoma - BMC Women's Health - BMC Blogs Network
Posted: June 10th, 2019, 5:00am GMT
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Woman chooses traditional medicine over radiation to treat cancer - APTN News
Posted: April 18th, 2019, 5:00am GMT
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Radiotherapy and Chemotherapy for Phyllodes Tumors - News-Medical.net
Posted: February 27th, 2019, 6:00am GMT
Radiotherapy and Chemotherapy for Phyllodes Tumors News-Medical.net -
Types of Breast Cancer - News-Medical.net
Posted: February 26th, 2019, 6:00am GMT
Types of Breast Cancer News-Medical.net -
Lump on left breast: Types, diagnosis, and other symptoms - Medical News Today
Posted: February 19th, 2019, 6:00am GMT
Lump on left breast: Types, diagnosis, and other symptoms Medical News Today -
Pink nodule on the toe of an infant - Clinical Advisor
Posted: February 14th, 2019, 2:49pm GMT
Pink nodule on the toe of an infant Clinical Advisor -
Wattle tree ID often not black or light - Ballarat Courier
Posted: January 24th, 2019, 6:00am GMT
Wattle tree ID often not black or light Ballarat Courier -
Rare moth species found first time in Karnataka - The New Indian Express
Posted: November 5th, 2018, 6:00am GMT
Rare moth species found first time in Karnataka The New Indian Express -
Lucence launches first molecular test to distinguish breast tumours - BSA bureau
Posted: October 30th, 2018, 5:00am GMT
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Time to tackle the big ‘C’ - The Tribune
Posted: October 27th, 2018, 5:00am GMT
Time to tackle the big ‘C’ The Tribune -
Challenges Remain in Treating Patients With Phyllodes Breast Tumors - OncLive
Posted: October 13th, 2018, 5:00am GMT
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Breast screening: how to record vacuum-assisted excisions - GOV.UK
Posted: October 4th, 2018, 5:00am GMT
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Each Type of Breast Cancer, Explained: Invasive, Non-Invasive, More - Prevention.com
Posted: August 15th, 2018, 5:00am GMT
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Acacias are well adapted - Katherine Times
Posted: July 23rd, 2018, 5:00am GMT
Acacias are well adapted Katherine Times -
Pea-sized lump turned into a gift of life for Perth mother Bec Bucci - The West Australian
Posted: September 8th, 2017, 5:00am GMT
Pea-sized lump turned into a gift of life for Perth mother Bec Bucci The West Australian -
Pea-sized lump turned into a gift of life for Perth mother Bec Bucci - The West Australian
Posted: September 8th, 2017, 5:00am GMT
Pea-sized lump turned into a gift of life for Perth mother Bec Bucci The West Australian -
New England gardens glow with wattle - Armidale Express
Posted: August 10th, 2017, 5:00am GMT
New England gardens glow with wattle Armidale Express -
The Spectrum of Triple-Negative Breast Disease - Am J Pathology
Posted: July 20th, 2017, 5:00am GMT
The Spectrum of Triple-Negative Breast Disease Am J Pathology -
Acacia may be lacking nitrogen or getting too much water - Arizona Daily Star
Posted: April 21st, 2017, 5:00am GMT
Acacia may be lacking nitrogen or getting too much water Arizona Daily Star -
Dr. Mohamed A. Atalla, MD | Largo, MD | Urologist | US News Doctors - U.S. News & World Report
Posted: January 6th, 2017, 4:34pm GMT
Dr. Mohamed A. Atalla, MD | Largo, MD | Urologist | US News Doctors U.S. News & World Report -
Wattle light up the garden - Armidale Express
Posted: October 13th, 2016, 5:00am GMT
Wattle light up the garden Armidale Express -
Lump In Breast – Cancer Or Benign Cysts In Young Women - Refinery29
Posted: August 17th, 2016, 5:00am GMT
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Low-grade nasopharyngeal papillary adenocarcinoma: a case report and r | OTT - Dove Medical Press
Posted: May 18th, 2016, 5:00am GMT
Low-grade nasopharyngeal papillary adenocarcinoma: a case report and r | OTT Dove Medical Press -
Breast Lump or Mass as a Symptom of Cancer | News - Breast Cancer News
Posted: April 6th, 2016, 12:05pm GMT
Breast Lump or Mass as a Symptom of Cancer | News Breast Cancer News -
Breast Cancer Risk Factors - Breast Cancer News
Posted: March 30th, 2016, 9:27am GMT
Breast Cancer Risk Factors Breast Cancer News -
Fatal Overdoses Rising From Sedatives Like Valium, Xanax – WebMD - WebMD
Posted: February 18th, 2016, 6:00am GMT
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Breast Cancer Overview | Epidemiology and Etiology | News - Breast Cancer News
Posted: February 17th, 2016, 11:10am GMT
Breast Cancer Overview | Epidemiology and Etiology | News Breast Cancer News -
Relationship between ultrasound elastography and myofibroblast distribution in breast cancer and its clinical significance | Scientific Reports - Nature.com
Posted: February 5th, 2016, 6:00am GMT
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High expression of Solute Carrier Family 1, member 5 (SLC1A5) is associated with poor prognosis in clear-cell renal cell carcinoma | Scientific Reports - Nature.com
Posted: November 24th, 2015, 6:00am GMT
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When benign breast tumours turn cancerous, Singapore News & Top Stories - The Straits Times
Posted: November 6th, 2015, 6:00am GMT
When benign breast tumours turn cancerous, Singapore News & Top Stories The Straits Times -
Expression profiling of prostate cancer tissue delineates genes associated with recurrence after prostatectomy | Scientific Reports - Nature.com
Posted: November 2nd, 2015, 6:00am GMT
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Singapore scientists uncover genetic landscape of distinct breast tumors - Medical Xpress
Posted: October 7th, 2015, 5:00am GMT
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Andi Lambert, wife of Capitals assistant Lane Lambert, dies at 45 - Washington Post
Posted: September 27th, 2015, 5:00am GMT
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Frozen treatment: Rockwood’s IceCure machine can solve benign breast tumors - The Spokesman Review
Posted: August 25th, 2015, 5:00am GMT
Frozen treatment: Rockwood’s IceCure machine can solve benign breast tumors The Spokesman Review -
Biodiversity may reduce the threat of disease - Mongabay.com
Posted: February 19th, 2015, 6:00am GMT
Biodiversity may reduce the threat of disease Mongabay.com -
Bare plants with bare roots - Lompoc Record
Posted: December 30th, 2014, 6:00am GMT
Bare plants with bare roots Lompoc Record -
Australian insects build houses to keep from drying out - Science AAAS
Posted: October 3rd, 2014, 5:00am GMT
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New wattle species for Victoria - The Weekly Times
Posted: August 27th, 2014, 5:00am GMT
New wattle species for Victoria The Weekly Times -
Caterpillar an expert in mimicry - Australian Geographic - Australian Geographic
Posted: April 17th, 2014, 5:00am GMT
Caterpillar an expert in mimicry - Australian Geographic Australian Geographic -
Say No To Breast Cancer - The Forum Newsgroup
Posted: October 3rd, 2013, 5:00am GMT
Say No To Breast Cancer The Forum Newsgroup -
EXCLUSIVE: Woman who had double mastectomy hits stage in play 44 days after operation - New York Daily News
Posted: June 23rd, 2013, 5:00am GMT
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Weird becomes familiar - Taranaki Daily News
Posted: June 14th, 2013, 5:00am GMT
Weird becomes familiar Taranaki Daily News -
Creepy Caterpillar With “Teeth” Scares Predators, Surprises Scientists - PetsLady.com
Posted: October 20th, 2012, 5:00am GMT
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The different types of breast cancer - Jamaica Observer
Posted: October 1st, 2012, 5:00am GMT
The different types of breast cancer Jamaica Observer -
Jade's courage inspires relative's close shave - The Northern Echo
Posted: September 1st, 2012, 5:00am GMT
Jade's courage inspires relative's close shave The Northern Echo -
For Laughfest, cancer survivors tell you their funniest stories - The Grand Rapids Press - MLive.com
Posted: March 13th, 2011, 6:00am GMT
For Laughfest, cancer survivors tell you their funniest stories The Grand Rapids Press - MLive.com -
JIM HUNSLEY: Chesterton boys soccer players wear pink shoelaces for breast cancer awareness month - nwitimes.com
Posted: October 6th, 2010, 5:00am GMT
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GMTV's Emma Crosby tells of her heartache, and relief, at discovering she had benign breast disease - Daily Mail
Posted: April 24th, 2010, 5:00am GMT
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Multivitamins Linked to Breast Cancer Risk - WebMD
Posted: April 1st, 2010, 5:00am GMT
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Walnuts Fight Breast Cancer - WebMD
Posted: April 21st, 2009, 5:00am GMT
PubMed - Phyllodes Tumor
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Fibroepithelial tumours of the breast-a review
Fetched: September 12th, 2021, 5:01am GMT by Melinda F Lerwill
Virchows Arch. 2021 Sep 10. doi: 10.1007/s00428-021-03175-6. Online ahead of print.
ABSTRACT
Fibroepithelial tumours of the breast are biphasic neoplasms composed of both epithelial and stromal elements, including the common fibroadenoma and the infrequent phyllodes tumour. The admixture of epithelium and stroma in the fibroadenoma shows intra- and pericanalicular patterns, and may display a variety of histological changes. Fibroadenoma variants include the cellular, juvenile, myxoid and complex forms. The cellular fibroadenoma may be difficult to distinguish from the benign phyllodes tumour. Stromal mitotic activity can be increased in fibroadenomas in the young and pregnant patients. Phyllodes tumours, neoplasms with the potential for recurrence, show an exaggerated intracanalicular growth pattern with broad stromal fronded architecture and stromal hypercellularity. They are graded into benign, borderline and malignant forms based on histological assessment of stromal features of hypercellularity, atypia, mitotic activity, overgrowth and the nature of the tumour borders. Classification of phyllodes tumours is imperfect, compounded by tumour heterogeneity with overlapping microscopic features among the different grades, especially in the borderline category. Malignant phyllodes tumours can metastasise and cause death. Determining which phyllodes tumours may behave aggressively has been difficult. The discovery of MED12 mutations in the pathogenesis of fibroepithelial tumours, together with other gene abnormalities in the progression pathway, has allowed refinements in diagnosis and prognosis.
PMID:34505197 | DOI:10.1007/s00428-021-03175-6
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Assessment of quantitative dynamic contrast-enhanced MRI in distinguishing different histologic grades of breast phyllode tumor
Fetched: September 8th, 2021, 5:01am GMT by Zhilong Yi
Eur Radiol. 2021 Sep 7. doi: 10.1007/s00330-021-08232-x. Online ahead of print.
ABSTRACT
OBJECTIVES: To investigate whether quantitative DCE-MRI (qDCE-MRI) could help distinguish breast phyllodes tumor (PT) grades.
MATERIALS AND METHODS: This retrospective study included 67 breast PTs (26 benign lesions, 25 borderline lesions, and 16 malignant lesions) from April 2016 to July 2020. MRI was performed with a 1.5-T MR system. Perfusion parameters (Ktrans, kep, ve, iAUC60) derived from qDCE-MRI, tumor size, and the mean ADC value were correlated with histologic grades using Spearman's rank correlation coefficient. Ktrans, kep, ve, and iAUC60 of three histologic grades were also calculated and compared.
RESULTS: The Spearman correlation coefficient with histologic grade of the tumor size was 0.578 (p < 0.001); the ADC value was not correlated with histologic grades of breast PT (p = 0.059). The Ktrans, kep, ve, and iAUC60 of benign breast PTs were significantly lower than those of borderline breast PTs (p < 0.001) and lower than those of malignant breast PTs (p < 0.001). In comparison, the Ktrans, ve, and iAUC60 of borderline breast PTs were significantly lower than those of malignant breast PTs (p < 0.001, p < 0.001, p = 0.007, respectively). For ROC analysis, AUCs of Ktrans, ve, and iAUC60 were higher than tumor size and ADC value for differentiating three PT grades.
CONCLUSION: Quantitative and semi-quantitative perfusion parameters (Ktrans, ve, and iAUC60, especially Ktrans) derived from qDCE-MRI showed better diagnosis efficiency than tumor size and ADC for grading breast PTs. Therefore, qDCE-MRI may be helpful for preoperative differentiating breast PT grades.
KEY POINTS: • Quantitative dynamic contrast-enhanced MRI can be used as a complementary noninvasive method to improve the differential diagnosis of breast PT. • Ktrans, ve, and iAUC60 derived from qDCE-MRI showed better diagnosis efficiency than tumor size and ADC for grading breast PTs.
PMID:34491383 | DOI:10.1007/s00330-021-08232-x
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Phyllodes tumor and its malignization into invasive ductal carcinoma a case report
Fetched: September 2nd, 2021, 5:02am GMT by A Jesenková
Rozhl Chir. 2021 Summer;100(6):295-301. doi: 10.33699/PIS.2021.100.6.295-301.
ABSTRACT
INTRODUCTION: Phyllodes tumors of the breast are rare and very distinct types of mammary neoplasms. They are characterized by their biphasicity, i.e. the presence of stromal and epithelial components at the same time. Malignancy is determined by the degree of stromal differentiation. The coexistence of the malignant epithelial component is a very rare phenomenon. Dozens of cases of simultaneous phyllodes tumor and epithelial malignancy have been reported so far. Nevertheless, the biological nature of this process is still an unexplained and a controversial topic.
CASE REPORT: In this paper, we present a case of a patient with a suddenly enlarging lesion in the breast. According to the first surgical resection, a diagnosis of high-grade malignant phyllodes tumor was made with fibrosarcoma differentiation, stromal overgrowth and suppression of the epithelial component. Examination of scar resistence in early postoperative period revealed a triple-negative invasive low-differentiated breast carcinoma with very high proliferative activity, thus malignization of the epithelial component of the tumor occurred. Shortly, a diagnosis of second recurrence was made, treatment included axillary lymph node dissection (ALND) with a negative histological findings. The patient underwent complex adjuvant chemotherapy and radiotherapy and remained disease free 3 years after the surgery.
CONCLUSION: Coexistence of phyllodes tumor and the breast carcinoma is very rare. The article describes the first published case, which documents the subsequent development of invasive low-differentiated ductal carcinoma immediately after resection of high-grade phyllodes tumor. Treatment and prognosis are generally determined by the characteristics of the carcinomatous component.
PMID:34465119 | DOI:10.33699/PIS.2021.100.6.295-301
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Recurrent Giant Malignant Phyllodes Tumor of the Breast
Fetched: August 31st, 2021, 5:01am GMT by Erik Kudela
Case Rep Obstet Gynecol. 2021 Aug 19;2021:2476691. doi: 10.1155/2021/2476691. eCollection 2021.
ABSTRACT
Phyllodes tumors (PTs) are rare fibroepithelial neoplasms of the breast. They have a proliferating stromal component that can be graded as benign, borderline, and malignant. In addition, they are associated with an increased risk of local recurrence and distant metastasis. The authors hereby present a case report of a 34-year-old woman with recurrent malignant PT with an increasing aggressiveness. There were two recurrences of giant tumors that consumed the entire right breast, which developed over a three-year period. The final surgical treatment was a total extirpation of the tumor with subsequent plastic reconstruction using a cutaneous flap from the region of the latissimus dorsi muscle. The patient died three months after the last recurrence due to multiorgan failure.
PMID:34457366 | PMC:PMC8390174 | DOI:10.1155/2021/2476691
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Benign myofibroblastic/epithelial lesions of the breast with minimally infiltrative margins
Fetched: August 30th, 2021, 5:02am GMT by Giada Maria Vecchio
Pathol Res Pract. 2021 Aug 4;226:153577. doi: 10.1016/j.prp.2021.153577. Online ahead of print.
ABSTRACT
A minority of mixed fibro-epithelial lesions of the breast lacks both fibroadenoma and phyllodes architectural patterns and have been previously labeled with different terms, including "hamartomas", "myoid/muscular hamartomas", "benign fibroadenomatous lesions" or "stromo-epithelial lesions of the breast". This study emphasizes the clinico-pathologic features of 5 cases of mammary benign fibro(stromo)-epithelial lesions sharing as a common morphologic theme the presence of minimally infiltrative margins due to the overgrowth of the stromal component into the surrounding fibro-fatty tissue. Notably the radiological features were suspicious for malignancy in 3 out of 5 cases. The following histologic features were seen in all cases: i) an epithelial component of benign glandular structures exhibiting the morphological spectrum of fibro-cystic disease; ii) a stromal component of bland-looking spindle cell myofibroblasts (vimentin + and α-smooth muscle actin +) set in a variably fibro-myxoid stroma. The present paper contributes to widen the morphological spectrum of the benign fibro-epithelial lesions of the breast, emphasizing the possibility that some cases, exhibiting a predominant myofibroblastic stromal component and minimally infiltrative margins, may be confused with other primary spindle cell mimickers of the breast. Accordingly, we propose the descriptive term "benign myofibroblastic/epithelial lesions of the breast with minimally infiltrative margins" for these previously underrecognized lesions.
PMID:34455362 | DOI:10.1016/j.prp.2021.153577
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Aggressive malignant phyllodes tumor of breast with omental metastases - A case report
Fetched: August 25th, 2021, 5:02am GMT by B Rajkrishna
Breast Dis. 2021 Apr 26. doi: 10.3233/BD-201054. Online ahead of print.
ABSTRACT
Distant metastasis from malignant Phyllodes tumour (PT) is rare. They generally metastasize to the lung, bone, pleura, and liver. We present a very rare case of a 25-year-old woman with intraabdominal metastases from malignant phyllodes tumour of the breast. She presented with left breast lump and the biopsy was Phyllodes tumour. She underwent a two staged surgery; left modified radical mastectomy followed by left latissimus dorsi musculocutaneous flap cover. She received adjuvant radiation therapy to left chest wall. Following which she developed intrabdominal mass which was proven to be metastasis from Phyllodes tumour. She was then advised palliative chemotherapy. Malignant Phyllodes with distant metastases has a dismal prognosis. We propose it is preferable to have a CT Thorax and Abdomen as a staging workup for patients with malignant PT to identify those with poor prognosis.
PMID:34420938 | DOI:10.3233/BD-201054
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Phyllodes Tumor Of The Breast
Fetched: August 22nd, 2021, 5:01am GMT by Faten Limaiem
2021 Jul 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–.
ABSTRACT
Phyllodes tumor of the breast is an infrequently encountered fibroepithelial neoplasm, which accounts for 0.3% to 1% of all tumors. Phyllodes tumor presents a morphologic continuum from benign to malignant. Based on histologic features, including nuclear atypia, stromal cellularity, mitotic activity, tumor margin appearance, and stromal overgrowth, the World Health Organization (WHO) classifies Phyllodes tumors benign, borderline, and malignant. Phyllodes tumors have an inherent recurrence and/or metastatic potential, which varies based on histologic grade. Their diagnosis is mainly established based on histopathological examination. However, the differential diagnosis between benign phyllodes tumors and fibroadenoma remains challenging, especially on core biopsy specimens.
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Two progressed malignant phyllodes tumors of the breast harbor alterations in genes frequently involved in other advanced cancers
Fetched: August 18th, 2021, 5:01am GMT by Mattea Reinisch
Orphanet J Rare Dis. 2021 Aug 16;16(1):363. doi: 10.1186/s13023-021-01986-z.
ABSTRACT
BACKGROUND: The genomic landscape of phyllodes tumors (PTs) of the breast is not well defined, especially in patients with advanced disease. To shed light on this topic, paired primary and progressed tumor samples from two patients with malignant PTs were subjected to next-generation sequencing (NGS) followed by functional analysis of genetic alterations using two prediction tools.
METHODS: The DNA of both the primary tumor and distant metastases of Patient 1 and the primary and recurrent tumor of Patient 2 were subjected to molecular profiling. NGS with the FoundationOne® assay was performed in a commercial molecular pathology laboratory. Two in silico prediction tools were used to estimate the pathogenicity of indicated genetic alterations.
RESULTS: In total, 38 genomic alterations were detected, of which 11 were predicted to be probably benign. In Patient 1, 14 aberrations were identified in the primary tumor and 17 in pulmonary metastases, 12 of which were identical. In the primary and recurrent tumor of Patient 2, 17 and 15 sequence variants, respectively, were found, with 13 overlapping findings. Affected genes included seven (TP53, TERT, APC, ARID1A, EGFR, KMT2D, and RB1) of the top 10 most frequently altered genes in other advanced cancer entities, as well as four actionable therapeutic targets (EGFR, KIT, PDGFRA, and BRIP1). Of note, seven genes coding for receptor tyrosine kinases were affected: three in Patient 1 and four in Patient 2. Several genes (e.g. EPHA3, EPHA7, and EPHB1) were shown to be altered for the first time in PTs.
CONCLUSIONS: The two progressed malignant PTs investigated here share some of the major genetic events occurring in other advanced cancers.
PMID:34399808 | PMC:PMC8365991 | DOI:10.1186/s13023-021-01986-z
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Acrometastases: The nasty alter ego of fingertip infections
Fetched: August 14th, 2021, 5:01am GMT by Collin Seng Kim Looi
Malays Fam Physician. 2021 Jun 3;16(2):86-89. doi: 10.51866/cr1059. eCollection 2021 Jul 22.
ABSTRACT
Fingertip infections are commonly diagnosed in primary care. There is a serious condition, acrometastases, that is often mistaken for these infections. Acrometastases are defined as metastases located distal to the elbow or knee. We present a case of a malignant phyllodes tumour with acrometastases to the distal phalanx of the left middle finger that was misdiagnosed as a fingertip infection on 2 separate occasions, highlighting the need for vigilance regarding acrometastases.
PMID:34386171 | PMC:PMC8346759 | DOI:10.51866/cr1059
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Malignant phyllodes tumor with synchronous metastases to axillary lymph nodes, lung at the presentation: a case report and literature review
Fetched: August 3rd, 2021, 5:02am GMT by Quang Hong Le
J Surg Case Rep. 2021 Jul 29;2021(7):rjab302. doi: 10.1093/jscr/rjab302. eCollection 2021 Jul.
ABSTRACT
Phyllodes tumors are rare mesenchymal tumors of breast. Malignant phyllodes tumors can develop metastases to distal organs with spreading hematogenously to most frequent sites as lungs, bone and brain. Regional lymph node enlargement is common but metastasis to lymph node is a very rare phenomenon with prevalence about 1.1-3.8%. In this report, we introduce a case of malignant phyllodes tumor of breast in 57-year-old female patient. Synchronous metastases to axillary lymph nodes and lung were found at the presentation. She was treated with mastectomy combined with axillary lymph node dissection and adjuvant chemotherapy. Axillary lymph node dissection can be considered in case of proven metastatic or suspiciously palpable lymph nodes.
PMID:34336184 | PMC:PMC8321595 | DOI:10.1093/jscr/rjab302