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Acinar Cell Carcinoma
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Acinic Cell Carcinoma
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Adenoid Cystic Carcinoma
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Adrenal Gland Cancer
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Ampulla Of Vater
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Anal Cancer
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Angiosarcoma
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Appendix Cancer
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Bile Duct Cancer
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Brain and CNS
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Carcinoid
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Endocrine/Neuroendocrine
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Gall Bladder Cancer
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Hemangioendothelioma
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Hepatoblastoma
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Pancreas
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Phyllodes
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PMP and Mucinous Tumors
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Rhabdomyosarcoma
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Sarcoma
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PMP and Mucinous Tumors (22 unread)
Google - Pseudomyxoma Peritonei
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From the 'mother of all surgeries' to 50 miles for Maggie's Centres - In Your Area
Posted: January 10th, 2022, 8:43am GMT
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Man defied the odds to spend 20 precious years with his family - Grimsby Live
Posted: January 10th, 2022, 4:00am GMT
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Letters to the Editor: Registered nurse program needs our support - Austin American-Statesman
Posted: January 9th, 2022, 11:30am GMT
Letters to the Editor: Registered nurse program needs our support Austin American-Statesman -
People who have saved others, inspired and changed lives in Merseyside - Liverpool Echo
Posted: December 25th, 2021, 5:33am GMT
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Steve Prescott Foundation donates £140,000 to two charities - Love Rugby League
Posted: December 21st, 2021, 9:41am GMT
Steve Prescott Foundation donates £140,000 to two charities Love Rugby League -
How You Can Fight Cancer Fatigue - Verywell Health
Posted: December 21st, 2021, 6:00am GMT
How You Can Fight Cancer Fatigue Verywell Health -
After throwing goodbye party, woman with cancer finds hope close to home in Austin - Austin American-Statesman
Posted: December 20th, 2021, 1:01pm GMT
After throwing goodbye party, woman with cancer finds hope close to home in Austin Austin American-Statesman -
Pseudomyxoma Peritonei (PMP): Causes and Risk Factors - Verywell Health
Posted: September 20th, 2021, 5:00am GMT
Pseudomyxoma Peritonei (PMP): Causes and Risk Factors Verywell Health -
Hot Chemotherapy or HIPEC Procedure - Treatment - Verywell Health
Posted: June 2nd, 2021, 5:00am GMT
Hot Chemotherapy or HIPEC Procedure - Treatment Verywell Health -
Apollo Hospital performs HIPEC surgery of woman - The New Indian Express
Posted: March 11th, 2021, 6:00am GMT
Apollo Hospital performs HIPEC surgery of woman The New Indian Express -
Older women with ovarian cancer may benefit from more aggressive treatment - Healio
Posted: January 14th, 2021, 6:00am GMT
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Pseudomyxoma Peritonei (PMP) Research - News-Medical.net
Posted: June 26th, 2019, 5:00am GMT
Pseudomyxoma Peritonei (PMP) Research News-Medical.net -
Review of Appendix Cancer Cases Finds Over Diagnosis - UC San Diego Health
Posted: June 7th, 2017, 5:00am GMT
Review of Appendix Cancer Cases Finds Over Diagnosis UC San Diego Health
PubMed - Pseudomyxoma Peritonei (PMP)
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Progression of perforated cystadenoma of the appendix to pseudomyxoma peritonei over 18 years. A case report
Fetched: January 16th, 2022, 5:01am GMT by Paul H Sugarbaker
Int J Surg Case Rep. 2022 Jan 10;91:106756. doi: 10.1016/j.ijscr.2022.106756. Online ahead of print.
ABSTRACT
INTRODUCTION AND IMPORTANCE: In the past, mucinous appendiceal neoplasms (MAN) greater than 2 cm in diameter were treated by a right colon resection. New data shows that treatment options are to be determined by the histopathologic grade of the appendiceal tumor and the condition of the wall of the appendix (intact vs. breached).
CASE PRESENTATION: A 39-year-old woman had an incidental diagnosis of a low-grade appendiceal mucinous neoplasm (LAMN) at the time of a hysterectomy. The appendiceal tumor had small quantities of mucus surrounding an enlarged appendix. No tumor cells were seen in the mucus by histologic study. The patient was placed in follow-up. Eighteen years later she required treatment for advanced pseudomyxoma peritonei.
CLINICAL DISCUSSION: When 5 different histopathologic types of MAN are considered with an intact vs. perforated wall of the appendix, four different treatment options develop. With LAMN and well or moderately differentiated mucinous appendiceal adenocarcinoma (MACA), the patient does not require operative intervention if the wall of the appendix is intact. If mucus or mucus plus tumor cells are identified outside the appendix an intervention is indicated. In patients, as the one presented, in whom only small amounts of mucus are outside the appendix, surveillance may be recommended.
CONCLUSIONS: In patients with a diagnosed low-grade MAN, dissemination to regional lymph nodes is rare. Dissemination to the peritoneal space places the patient at risk to develop pseudomyxoma peritonei. As this case report illustrates, if surveillance is recommended, long-term follow-up is required.
PMID:35032752 | DOI:10.1016/j.ijscr.2022.106756
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Peritoneal surface malignancy spread reoperations after cytoreductive surgery + HIPEC
Fetched: January 14th, 2022, 5:01am GMT by F Antoš
Rozhl Chir. 2021 Winter;100(10):469-474. doi: 10.33699/PIS.2021.100.10.469-474.
ABSTRACT
INTRODUCTION: Peritoneal malignancies (PM) are observed in about 1030% of patients suffering from gastrointestinal malignant diseases, both in connection with the primary surgical management or as metachronous metastases due to cancer recurrence.
METHODS: In the 1980s a new method of cytoreductive surgery (CRS) + HIPEC (hyperthermic intraperitoneal chemotherapy) was introduced. Today, we consider this method to be the gold standard for treatment of pseudomyxoma peritonei and peritoneal mesothelioma. The method increases overall survival (OS) of patients diagnosed with colorectal cancer, primary peritoneal and ovarian cancers. However, the disease recurs after this demanding treatment in the certain group of patients, approximately in 2544% of patients treated for pseudomyxoma peritonei, and in 40% and up to 82% of those treated for mesothelioma and colorectal cancer, respectively. Based on literary data (PubMed-Medline, last 5 years) and our own experience we present the basic factors associated with tumor recurrence, possibility of treatment using repeated CRS + HIPEC, data regarding second-look operations, and as applicable, prophylactic HIPEC.
CONCLUSION: The method CRS + HIPEC provides an effective treatment of peritoneal carcinomatosis even in cases of recurrence. The second-look operations and prophylactic HIPEC may favorably affect the prognosis after primary R0 resections.
PMID:35021837 | DOI:10.33699/PIS.2021.100.10.469-474
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Peritoneal metastases found in routinely resected specimens after cytoreductive surgery and heated intraperitoneal chemotherapy
Fetched: January 12th, 2022, 5:01am GMT by Jesper Nors
Eur J Surg Oncol. 2021 Dec 25:S0748-7983(21)00996-3. doi: 10.1016/j.ejso.2021.12.026. Online ahead of print.
ABSTRACT
INTRODUCTION: Peritoneal metastases (PM) originating from colorectal cancer (CRC) and pseudomyxoma peritonei (PMP) can be treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Certain sites in the peritoneal cavity are prone to contain PM and are, therefore, routinely resected. The aim of this study is to investigate the frequency of disease in CRS specimens routinely resected. Secondly, to investigate if the risk of finding PM in routinely resected specimen is associated with involvement of anatomic related peritoneal areas.
MATERIALS AND METHODS: This study investigated 433 patients diagnosed with PMP (n = 119) or PM from CRC (n = 314) and operated with CRS + HIPEC between June 2006 and November 2020 at a national center. Baseline data were prospectively registered. Pathology reports were reviewed for the presence of metastases in the routinely resected umbilicus, ligamentum teres hepatis, ovaries and greater omentum. Tumor extent was estimated using the Dutch region count.
RESULTS: PM was found in 14.7% of umbilical resections, in 17.4% of the resected ligamentum teres hepatis, in 48.2% of the resected ovaries and in 49.5% of the greater omentum specimens. We found an association between macroscopic disease involvement of the nearest region and risk of PM found in the related resections. Seven of 31 women with no macroscopically visible disease in the pelvis had PM diagnosed in the resected ovaries.
CONCLUSIONS: A substantial proportion of routine resections held histologic verified PM. Our results may advocate for a routinely performed resection of the umbilicus, ligamentum teres hepatis, ovaries and greater omentum.
PMID:35012833 | DOI:10.1016/j.ejso.2021.12.026
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A Rare Case of Psoas Abscess Secondary to Mucinous Adenocarcinoma of the Appendix: A Case Report
Fetched: January 11th, 2022, 5:01am GMT by Rudra M Prabhu
J Orthop Case Rep. 2021 Aug;11(8):1-5. doi: 10.13107/jocr.2021.v11.i08.2340.
ABSTRACT
INTRODUCTION: Iliacus and psoas muscles are located in an extraperitoneal location forming the iliopsoas compartment. Iliopsoas abscess is a myositis involving this compartment. Pseudomyxoma peritonei is characterized by an abundant extracellular collection of mucin in the peritoneal cavity. When this collection is retroperitoneal, it is termed as pseudomyxoma extraperitonei. We present to you the case of a 52-year-old female with psoas abscess secondary to mucinous adenocarcinoma of the appendix, which was later diagnosed as pseudomyxoma extraperitonei.
CASE PRESENTATION: A 52-year-old female presented with pain in the right flank with discharging sinuses since one year. She had previously undergone two surgeries in the past 1 year for drainage of the abscess and had taken first line anti-tubercular treatment for around 6 months. She was managed in our institute by an open drainage of the abscess. The culture reports showed an infection with E. coli. The histopathology sections showed abundant pools of extracellular mucin with strips of columnar epithelium which indicated the pathology to be a mucinous adenocarcinoma. A contrast-enhanced computed tomography scan of the abdomen and pelvis showed a ruptured appendix mucocele and a collection in the right psoas muscle showing fistulous communication with the cecum and extending to the suture site in the right flank. Anti-tubercular treatment was stopped and an oncology opinion was taken. The patient was managed with a palliative ileostomy.
CONCLUSION: It is important to keep in mind diagnostic possibilities other than tuberculosis of the spine when managing a patient with an iliopsoas abscess. These include pathologies of the gastrointestinal and genitourinary tract, which need to be diagnosed and managed early.
PMID:35004364 | PMC:PMC8686507 | DOI:10.13107/jocr.2021.v11.i08.2340
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ASO Visual Abstract: Overall Survival is More Closely Associated with Peritoneal than Primary Appendiceal Pathological Grade in Pseudomyxoma Peritonei with Discordant Pathology
Fetched: January 7th, 2022, 5:02am GMT by Ayaz Ahmed Memon
Ann Surg Oncol. 2022 Jan 6. doi: 10.1245/s10434-021-11105-8. Online ahead of print.
NO ABSTRACT
PMID:34988828 | DOI:10.1245/s10434-021-11105-8
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The Clinical Desire for Pressurized Intraperitoneal Aerosol Chemotherapy in South Korea: An Electronic Survey-based Study
Fetched: January 1st, 2022, 5:01am GMT by Eun Ji Lee
Anticancer Res. 2022 Jan;42(1):363-371. doi: 10.21873/anticanres.15494.
ABSTRACT
BACKGROUND/AIM: To evaluate the clinical desire for pressurized intraperitoneal aerosol chemotherapy (PIPAC) in South Korea.
PATIENTS AND METHODS: We performed an online survey on surgical oncologists between November and December 2019 using a questionnaire consisting of 20 questions.
RESULTS: A total of 164 respondents answered the questionnaire. Among those specialized in ovarian cancer, pseudomyxoma peritonei, and malignant mesothelioma 41.7-50% preferred PIPAC for the curative treatment of primary diseases, whereas 32.7-33.3% majoring in colorectal and hepatobiliary cancers chose it for the palliative treatment of recurrent diseases. Furthermore, 66.7-95.2% considered PIPAC appropriate for the cancers they specialized in, and 76-78.7% expected a treatment response of more than 50% and considered grade 1 or 2 complications acceptable. Most respondents answered the reasonable costs to purchase and implement PIPAC once at between 1,000,000-5,000,000 South Korean Won (KRW).
CONCLUSION: Most Korean surgical oncologists expected relatively high tumor response rates with minor toxicities through the repeated implementation of PIPAC.
PMID:34969746 | DOI:10.21873/anticanres.15494
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A case of Pseudomyxoma Peritonei of an unexpected origin
Fetched: December 22nd, 2021, 5:01am GMT by Marie Csanyi-Bastien
Diagn Pathol. 2021 Dec 20;16(1):119. doi: 10.1186/s13000-021-01179-z.
ABSTRACT
BACKGROUND: Pseudomyxoma peritonei (PMP) is a complex and partially understood disease defined by mucin deposits in the peritoneal cavity, mostly of appendiceal origin caused by the rupture of a mucocele often containing Low or High grade Appendiceal Mucinous Neoplasm (LAMN/HAMN). Other origins include primitive ovarian mucinous cystadenoma or cystadenocarcinoma almost always with an associated teratoma, but to our knowledge no case of ovarian teratomatous appendiceal-like mucocele with LAMN has been reported as a cause of PMP.
CASE PRESENTATION: A 25-year old female with infertility was diagnosed with an isolated left ovarian tumor in a context of PMP. Histological examination revealed an ovarian teratoma containing an appendiceal-like structure with mucocele and LAMN, without any associated lesion of the appendix on full histological analysis. Molecular characterization of the ovarian lesion showed co-KRAS and GNAS mutations, as described in PMP of appendiceal origin, while only KRAS mutations are reported in primitive ovarian mucinous tumor.
CONCLUSIONS: Detection of co-KRAS and GNAS mutations in our case of ovarian teratomatous appendiceal-like mucocele with LAMN shows that when PMP derives from a mucinous ovarian lesion (with histological proof of none-appendiceal involvement), it is probably of a digestive teratomatous origin, emphasizing the need to actively search for tetatomatous signs in a context of ovarian PMP.
PMID:34930348 | PMC:PMC8686532 | DOI:10.1186/s13000-021-01179-z
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Clinicopathological analysis and surgical strategy of primary appendiceal neoplasms
Fetched: December 20th, 2021, 5:01am GMT by Y C Wu
Zhonghua Wei Chang Wai Ke Za Zhi. 2021 Dec 25;24(12):1065-1072. doi: 10.3760/cma.j.cn441530-20201122-00621.
ABSTRACT
Objective: To investigate the clinicopathological features, surgical methods and prognosis of primary appendiceal neoplasms. Methods: A descriptive case series study was performed. Clinical data of patients diagnosed with primary appendiceal neoplasms in Peking University First Hospital from 2006 to 2017 were retrospectively analyzed. Patients who underwent surgery and were confirmed as appendiceal neoplasms by postoperative pathology were included. Cases of cecal tumor invading the appendix and other organ tumors implanting in the appendix and cases of recurrent appendix tumors were excluded Pathological classification was based on the 4th edition of the WHO classification of digestive tract tumors (2010 edition), and the efficacy of operation methods of low grade appendiceal mucinous neoplasm (LAMN) were analyzed. Results: A total of 115 patients were enrolled, including 52 males and 63 females with a median age of 59 (51, 71) years. Clinical symptoms usually manifested as dormant pain in the right lower quadrant, migrating right lower abdominal pain, fever and bloating. Twenty-four cases were accidentally discovered during surgery, and 21 cases were found by physical examination. The preoperative diagnosis rate of CT and ultrasound was 40.2% (43/107) and 25.5% (24/94) respectively. The postoperative pathological types contained 83 cases of LAMN, 12 cases of mucinous adenocarcinoma, 9 cases of appendiceal neuroendocrine neoplasms (aNEN), 2 cases of mucinous adenocarcinoma with signet ring cells, 3 cases of serrated adenoma, 2 cases of goblet cell carcinoid, 2 cases of lymphoma, 1 case of leiomyoma and 1 case of schwannomas. All the patients underwent surgical resection, including 41 cases of appendectomy, 21 cases of partial cecectomy, 48 cases of right hemicolectomy, and 5 cases of combined organ resection due to appendiceal tumor infiltration or dissemination. Eighteen cases were diagnosed with pseudomyxoma peritonei (PMP) during operation. A total of 98 patients were enrolled for follow-up. The median follow-up time was 58 (5-172) months. The 5-year disease-free survival (DFS) rate was 84.5% and 5-year overall survival (OS) was 88.2%. Multivariate analysis revealed that high-grade malignancy tumors (HR=25.881, 95% CI: 2.827-236.935, P=0.004) and PMP formation (HR=42.166, 95% CI: 3.470-512.439,P=0.003) were independent risk factors for prognosis. Patients undergoing right hemicolectomy presented longer operation time, more blood loss and higher morbidity of complication as compared to those undergoing appendectomy and partial cecectomy (all P<0.05), while no significant differences in 5-year DFS (P=0.627) and 5-year OS (P=0.718) were found. Conclusions: Primary appendiceal neoplasms usually have no typical features, accompanied with low preoperative diagnosis rate. The common pathological types are LAMN, mucinous adenocarcinoma and aNEN. Appendectomy or partial cecectomy for LAMN may achieve satisfactory prognosis. High-grade malignancy tumors and PMP formation are independent risk factors for prognosis.
PMID:34923789 | DOI:10.3760/cma.j.cn441530-20201122-00621
Trial - Pseudomyxoma Peritonei
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ERAS® Guidelines Validation of CRS With or Without HIPEC
Posted: January 11th, 2022, 3:00pm GMT
Condition: Peritoneal Diseases
Interventions: Other: Pre-ERAS® phase (current clinical practice); Other: Post-ERAS® implementation phase
Sponsor: Hospices Civils de Lyon
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