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Google - Pseudomyxoma Peritonei
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K-pop star BoA’s brother, a music video director, passes away due to cancer - Manila Bulletin
Posted: September 5th, 2021, 10:49am GMT
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'We weren't thinking it would harm us.' LI's 9/11 first responders endure pain, illnesses - Newsday
Posted: September 4th, 2021, 9:43pm GMT
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Jane Wooten | Obituaries | hendersonvillestandard.com - Hendersonville Standard
Posted: August 30th, 2021, 8:02am GMT
Jane Wooten | Obituaries | hendersonvillestandard.com Hendersonville Standard -
Nathan Abrams - The West Milford Messenger
Posted: August 25th, 2021, 5:00am GMT
Nathan Abrams The West Milford Messenger -
'3 weeks after starting my health kick I was diagnosed with cancer, but it didn’t stop me' - Body and Soul
Posted: August 24th, 2021, 9:43pm GMT
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Dunfermline family angry after Hampshire Clinic 'missed opportunity' to extend devoted dad's life - Dunfermline Press
Posted: August 24th, 2021, 1:30pm GMT
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Hampshire Clinic 'missed opportunity' to extend devoted dad's life - Basingstoke Gazette
Posted: August 24th, 2021, 10:17am GMT
Hampshire Clinic 'missed opportunity' to extend devoted dad's life Basingstoke Gazette -
Woman with rare cancer organises fundraising swimathon - cumbriacrack.com - Cumbria Crack
Posted: August 11th, 2021, 4:10am GMT
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How Eosinophilic Gastritis and/or Eosinophilic Duodenitis Is Diagnosed - Verywell Health
Posted: July 21st, 2021, 5:00am GMT
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Two children face being orphaned as mum battles terminal cancer after dad's death - The Mirror
Posted: July 14th, 2021, 5:00am GMT
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A ride to remember: Cancer survivor prepares for LOWVELO 2021 - Medical University of South Carolina
Posted: June 10th, 2021, 5:00am GMT
A ride to remember: Cancer survivor prepares for LOWVELO 2021 Medical University of South Carolina -
Pseudomyxoma Peritonei Diagnosis - News-Medical.net
Posted: May 25th, 2021, 5:00am GMT
Pseudomyxoma Peritonei Diagnosis News-Medical.net -
Little boy in Emmaus lifts spirits as he sells lemonade to raise money for cancer research - 69News WFMZ-TV
Posted: May 19th, 2021, 5:00am GMT
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16 stories from across Merseyside that will restore your faith in humanity - Liverpool Echo
Posted: May 16th, 2021, 5:00am GMT
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Peritoneal Cancer: Symptoms, Causes, Diagnosis, and Treatment - Verywell Health
Posted: April 21st, 2021, 5:00am GMT
Peritoneal Cancer: Symptoms, Causes, Diagnosis, and Treatment Verywell Health -
ESMO - European Society for Medical Oncology - Knovel
Posted: April 15th, 2021, 2:36pm GMT
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What You Should Know About the IPMN Tumor - Verywell Health
Posted: March 25th, 2021, 5:00am GMT
What You Should Know About the IPMN Tumor Verywell Health -
Ann Rodrigues Obituary (1965 - 2021) - North Providence, RI - The Providence Journal - Legacy.com
Posted: March 13th, 2021, 6:00am GMT
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Apollo Hospital performs HIPEC surgery of woman - The New Indian Express
Posted: March 11th, 2021, 6:00am GMT
Apollo Hospital performs HIPEC surgery of woman The New Indian Express -
Rare Disease Day Quiz 2021 - On Medicine - BMC Blogs Network
Posted: February 26th, 2021, 6:00am GMT
Rare Disease Day Quiz 2021 - On Medicine BMC Blogs Network -
Gastric Cancer: Overview and More - Verywell Health
Posted: February 23rd, 2021, 6:00am GMT
Gastric Cancer: Overview and More Verywell Health -
Carcinoid Cancer: Overview and More - Verywell Health
Posted: February 11th, 2021, 6:00am GMT
Carcinoid Cancer: Overview and More Verywell Health -
Ann Elizabeth (Miller) Williams | Obituaries | dnews.com - Moscow-Pullman Daily News
Posted: December 17th, 2020, 6:00am GMT
Ann Elizabeth (Miller) Williams | Obituaries | dnews.com Moscow-Pullman Daily News -
Rothbury ex-GP's last-ditch treatment bid for stage 4 cancer so rare she'd never heard of it - Chronicle Live
Posted: December 7th, 2020, 6:00am GMT
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What You Should Know About Appendix Cancer | Dana-Farber Cancer Institute - Dana-Farber Cancer Institute
Posted: December 3rd, 2020, 6:00am GMT
What You Should Know About Appendix Cancer | Dana-Farber Cancer Institute Dana-Farber Cancer Institute -
Duodenal Cancer: Overview and More - Verywell Health
Posted: November 24th, 2020, 6:00am GMT
Duodenal Cancer: Overview and More Verywell Health -
Hernia: Types, Symptoms, Causes, Diagnosis, Treatment - Verywell Health
Posted: November 22nd, 2020, 6:00am GMT
Hernia: Types, Symptoms, Causes, Diagnosis, Treatment Verywell Health -
Corkman: I had 13 hour surgery for rare cancer - Echo Live
Posted: November 11th, 2020, 6:00am GMT
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Bridge lit amber - how St Helens showed its gratitude for Steve Prescott's legacy - St Helens Star
Posted: November 10th, 2020, 6:00am GMT
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What to Expect on the Day of Your Exploratory Laparotomy - Verywell Health
Posted: November 5th, 2020, 6:00am GMT
What to Expect on the Day of Your Exploratory Laparotomy Verywell Health -
Help cancer patients buy back time - Southern Star Newspaper
Posted: October 20th, 2020, 5:00am GMT
Help cancer patients buy back time Southern Star Newspaper -
Malignant Bowel Obstruction in End Stage Colon Cancer - Verywell Health
Posted: September 28th, 2020, 5:00am GMT
Malignant Bowel Obstruction in End Stage Colon Cancer Verywell Health -
CSR: Balco Medical Centre brings Naya Raipur on the global map as a state-of-the-art cancer care specialty hospital - IndiaCSR
Posted: September 16th, 2020, 10:56am GMT
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'I'll be an Englishman in a kilt doing Virtual Kiltwalk in Wales,' says man with incurable cancer - HeraldScotland
Posted: September 8th, 2020, 5:00am GMT
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Tumor Markers: Definition and Examples - Cancer - Verywell Health
Posted: September 7th, 2020, 5:00am GMT
Tumor Markers: Definition and Examples - Cancer Verywell Health -
Appendix Cancer: An Elusive Diagnosis - Curetoday.com
Posted: August 26th, 2020, 5:00am GMT
Appendix Cancer: An Elusive Diagnosis Curetoday.com -
Understanding What Chemorefractory Means - Verywell Health
Posted: August 21st, 2020, 5:00am GMT
Understanding What Chemorefractory Means Verywell Health -
Everything You Need to Know About Appendicitis - Verywell Health
Posted: August 3rd, 2020, 5:00am GMT
Everything You Need to Know About Appendicitis Verywell Health -
Sports Hernia Symptoms and Treatment - Verywell Health
Posted: May 10th, 2020, 5:00am GMT
Sports Hernia Symptoms and Treatment Verywell Health -
How Mesothelioma Is Treated - Verywell Health
Posted: March 27th, 2020, 5:00am GMT
How Mesothelioma Is Treated Verywell Health -
Alumna Spotlight: Lauren Smith - The Beacon
Posted: March 18th, 2020, 5:00am GMT
Alumna Spotlight: Lauren Smith The Beacon -
Celebrate the inspirational women in your life for International Women's Day - St Helens Star
Posted: March 7th, 2020, 6:00am GMT
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Meet the cancer survivor who credits Steve Prescott with saving his life - St Helens Star
Posted: March 5th, 2020, 6:00am GMT
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Norwich man defies odds thank medical staff after life changing bowel transplant - Eastern Daily Press
Posted: February 12th, 2020, 6:00am GMT
Norwich man defies odds thank medical staff after life changing bowel transplant Eastern Daily Press -
How Diverticulitis Is Diagnosed - Verywell Health
Posted: January 15th, 2020, 6:00am GMT
How Diverticulitis Is Diagnosed Verywell Health -
Abdominal Obesity and Health Risk - Verywell Health
Posted: January 10th, 2020, 6:00am GMT
Abdominal Obesity and Health Risk Verywell Health -
Greensburg man taking his battle against rare cancer to Australia - TribLIVE
Posted: December 12th, 2019, 6:00am GMT
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A Surgical First for Removal of an Appendiceal Neoplasm - MedPage Today
Posted: November 25th, 2019, 6:00am GMT
A Surgical First for Removal of an Appendiceal Neoplasm MedPage Today -
JAMESON BRANSON Obituary (1954 - 2019) - WAUCONDA, IL - Daily Herald - Legacy.com
Posted: November 24th, 2019, 6:00am GMT
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Reasons for a Resection Surgery - Verywell Health
Posted: November 11th, 2019, 6:00am GMT
Reasons for a Resection Surgery Verywell Health -
Octapharma's fibryga® Receives European Label Extension to Treat Acquired Fibrinogen Deficiency (AFD) - Business Wire
Posted: November 5th, 2019, 6:00am GMT
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Octapharma USA sponsors ASA Symposium on fibrinogen supplementation in surgical patients - EurekAlert
Posted: November 5th, 2019, 6:00am GMT
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Man lost 100 pounds diagnosed with liver disease, had cancer - TODAY
Posted: October 16th, 2019, 5:00am GMT
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Woman's rare type of cancer makes her look pregnant - Metro.co.uk
Posted: September 24th, 2019, 5:00am GMT
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Woman with rare cancer type left looking nine months pregnant - Yahoo News
Posted: September 24th, 2019, 5:00am GMT
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Mother, 35, reveals how her two-in-a-million cancer leaves people thinking she's pregnant - Daily Mail
Posted: September 23rd, 2019, 5:00am GMT
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Hidden scars of Yorkshire cancer nurse's private battle as a new mum - Yorkshire Post
Posted: July 13th, 2019, 5:00am GMT
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2,000-mile mini-motorbike challenge for Adam Alderson | Darlington and Stockton Times - Darlington and Stockton Times
Posted: June 30th, 2019, 5:00am GMT
2,000-mile mini-motorbike challenge for Adam Alderson | Darlington and Stockton Times Darlington and Stockton Times -
Pseudomyxoma Peritonei (PMP) Research - News-Medical.net
Posted: June 26th, 2019, 5:00am GMT
Pseudomyxoma Peritonei (PMP) Research News-Medical.net -
Symptoms and causes of pseudomyxoma peritonei (PMP) - News-Medical.net
Posted: February 27th, 2019, 6:00am GMT
Symptoms and causes of pseudomyxoma peritonei (PMP) News-Medical.net -
Treatment Options for Pseudomyxoma Peritonei - News-Medical.net
Posted: February 27th, 2019, 6:00am GMT
Treatment Options for Pseudomyxoma Peritonei News-Medical.net -
Appendix Cancer - Pseudomyxoma Peritonei (PMP) - News-Medical.net
Posted: February 27th, 2019, 6:00am GMT
Appendix Cancer - Pseudomyxoma Peritonei (PMP) News-Medical.net -
Appendix Cancer - Pseudomyxoma Peritonei (PMP) - News-Medical.net
Posted: February 27th, 2019, 6:00am GMT
Appendix Cancer - Pseudomyxoma Peritonei (PMP) News-Medical.net -
Experience of applying cytoreductive surgery and hyperthermic intraper | TCRM - Dove Medical Press
Posted: January 14th, 2019, 6:00am GMT
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Rare tumor removed: Ahmedabad doctors help jelly-man make the cut! - Times of India
Posted: December 29th, 2018, 6:00am GMT
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Octapharma receives Swissmedic approval for fibryga® to treat congenital and acquired fibrinogen deficiencies - Business Wire
Posted: November 26th, 2018, 6:00am GMT
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Visual Guide to Appendix Cancer - WebMD
Posted: October 15th, 2018, 1:22am GMT
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Leonard Boswell, Veterans' Champion in the House, Dies at 84 (Published 2018) - New York Times
Posted: August 20th, 2018, 5:00am GMT
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Leonard Boswell, Veterans’ Champion in the House, Dies at 84 - New York Times
Posted: August 20th, 2018, 5:00am GMT
Leonard Boswell, Veterans’ Champion in the House, Dies at 84 New York Times -
Former Iowa Congressman Leonard Boswell has died - Radio Iowa
Posted: August 17th, 2018, 5:00am GMT
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Genetic mutations of appendix cancer identified - BSA bureau
Posted: August 9th, 2018, 5:00am GMT
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Researchers identify genetic mutations of appendix cancer - BSI bureau
Posted: August 9th, 2018, 5:00am GMT
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Cornhole Tournament May Save Colorado Dad’s Life: ‘What Life’s All About’ - CBS Denver
Posted: July 29th, 2018, 5:00am GMT
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Tributes paid to 'shining light' of Cambuslang Rangers after popular businessman loses long battle with cancer - Daily Record
Posted: May 16th, 2018, 5:00am GMT
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Common Tests Used to Diagnose Abdominal Pain - Verywell Health
Posted: May 10th, 2018, 9:28pm GMT
Common Tests Used to Diagnose Abdominal Pain Verywell Health -
Cecum Cancer: Overview and More - Verywell Health
Posted: May 10th, 2018, 4:28am GMT
Cecum Cancer: Overview and More Verywell Health -
What Indolent Means in a Medical Diagnosis - Verywell Health
Posted: May 9th, 2018, 6:12pm GMT
What Indolent Means in a Medical Diagnosis Verywell Health -
Cancer symptoms: What is 'jelly belly' and are you at risk? - Express
Posted: March 28th, 2018, 5:00am GMT
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Surgical approach to a malignant appendix - The Hippocratic Post
Posted: August 31st, 2017, 5:00am GMT
Surgical approach to a malignant appendix The Hippocratic Post -
Applause for first inpatient in Emory University Hospital Tower - Emory News Center
Posted: August 30th, 2017, 5:00am GMT
Applause for first inpatient in Emory University Hospital Tower Emory News Center -
Woman battling jelly belly: I had 10 organs removed - Express.co.uk
Posted: July 30th, 2017, 5:00am GMT
Woman battling jelly belly: I had 10 organs removed Express.co.uk -
Former DARE officer dies | News | theadanews.com - Theadanews
Posted: June 26th, 2017, 5:00am GMT
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Low-grade appendix tumors often over-diagnosed as invasive cancer - Healio
Posted: June 9th, 2017, 5:00am GMT
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Hampshire mum bares 13-inch tummy scar - Daily Mail
Posted: May 12th, 2017, 5:00am GMT
Hampshire mum bares 13-inch tummy scar Daily Mail -
Cancer Patient Survives Having Eight Organs Removed - And Now He's Planning His Wedding - Huffington Post UK
Posted: March 1st, 2017, 6:00am GMT
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Man is FOURTH person to survive multiple organ transplant - Daily Mail
Posted: February 28th, 2017, 6:00am GMT
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Brave mum who had 'the mother of all surgeries' recovers after surgeons remove tumour weighing a STONE - Scottish Daily Record
Posted: February 12th, 2016, 6:00am GMT
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Audrey Hepburn's son: 'One day we will find a cure for the cancer that killed my mother' - Express.co.uk
Posted: October 19th, 2015, 5:00am GMT
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Intraoperative Hyperthermic Intraperitoneal Chemotherapy in Patients With Advanced Ovarian Cancer - Cancer Network
Posted: September 15th, 2015, 5:00am GMT
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Steve Prescott: Dying rugby league star had surgery to help save others - BBC News
Posted: September 14th, 2015, 5:00am GMT
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Pseudomyxoma peritonei sufferer Nikki Piper talks about her fight for survival - Daily Echo
Posted: August 4th, 2015, 5:00am GMT
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Botched cancer surgery turned my husband into a stranger - New York Post
Posted: July 12th, 2015, 5:00am GMT
Botched cancer surgery turned my husband into a stranger New York Post -
Cancer survivor Susan Oliver beacon of hope for all sufferers - Belfast Telegraph
Posted: June 10th, 2015, 5:00am GMT
Cancer survivor Susan Oliver beacon of hope for all sufferers Belfast Telegraph -
Doctor: Appendiceal cancer now very curable - WBAL Baltimore
Posted: May 27th, 2015, 5:00am GMT
Doctor: Appendiceal cancer now very curable WBAL Baltimore -
Patients travel to Basingstoke hospital from across Europe to share stories of Pseudomyxoma Peritonei - Basingstoke Gazette
Posted: January 19th, 2015, 6:00am GMT
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Peritoneal Carcinosis and HIPEC: A second chance for patients, thanks to animal research - Speaking of Research
Posted: October 30th, 2014, 5:00am GMT
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Cancer patient has belly button removed to stop rare form of disease - Daily Mail
Posted: August 18th, 2014, 5:00am GMT
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Husband Forgets How to Have Sex After Botched Cancer Surgery - ABC News
Posted: February 20th, 2014, 6:00am GMT
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Renowned cancer surgeon joins Edward Cancer Center - Positively Naperville
Posted: April 17th, 2013, 5:00am GMT
Renowned cancer surgeon joins Edward Cancer Center Positively Naperville -
New hope for colorectal cancer patients - The Hindu
Posted: March 25th, 2013, 5:00am GMT
New hope for colorectal cancer patients The Hindu
PubMed - Pseudomyxoma Peritonei (PMP)
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Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei of Appendiceal Origin: A Single Center Experience
Fetched: September 14th, 2021, 5:01am GMT by Francesco Santullo
Front Surg. 2021 Aug 26;8:715119. doi: 10.3389/fsurg.2021.715119. eCollection 2021.
ABSTRACT
Background: Pseudomyxoma peritonei (PMP) originating from appendiceal mucinous neoplasm is a rare peritoneal malignancy characterized by the progressive intraperitoneal accumulation of mucus leading to death if left untreated. In recent years, cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) offered increased survival rates. This study aims to identify the clinical, pathological, and surgical features influencing safety and survival outcomes of patients undergoing CRS and HIPEC for PMP of appendiceal origin. Methods: A retrospective analysis of all patients undergoing CRS and HIPEC for PMP of appendiceal origin from January 2015 to May 2019 was conducted at our institution. Results: Study population included 50 patients (74% female, 26% male). The median age at CRS was 60 (38-84). The median peritoneal cancer index (PCI) was 17. Complete cytoreductive surgery (CC 0-1) was achieved in 47 patients (94%). HIPEC chemotherapeutic regimen was based on oxaliplatin for 13 (28%) patients and mitomycin for 34 (72%) patients. We experienced a total of 19 (38%) postoperative complications, of which 14 (74%) of grade I-II and 5 (26%) of grade III-IV, according to the Clavien-Dindo classification. The median follow-up period was 27 months (12-107) from the date of cytoreductive surgery. The mean survival rate was 100 months, with a 5-year OS of 91%. The mean progression-free survival rate was 77 months (0-107), with a 5-year PFS of 63%. Multivariate analysis identified adenocarcinoma histotype and incomplete cytoreduction to significantly worsen progression-free survival, while incomplete cytoreduction was the only independent predictor of poorer overall survival. Conclusion: Complete cytoreduction and appendiceal neoplasm histotype play a crucial role in the survival of patients affected by PMP of appendiceal origin. The rates of morbidity associated with CRS and HIPEC for PMP are acceptable.
PMID:34513915 | PMC:PMC8427490 | DOI:10.3389/fsurg.2021.715119
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Prognostic Significance of Preoperative Tumor Markers in Pseudomyxoma Peritonei from Low-Grade Appendiceal Mucinous Neoplasm: a Study from the US HIPEC Collaborative
Fetched: September 12th, 2021, 5:01am GMT by Wasay Nizam
J Gastrointest Surg. 2021 Sep 10. doi: 10.1007/s11605-021-05075-1. Online ahead of print.
ABSTRACT
BACKGROUND: Tumor markers are commonly utilized in the diagnostic evaluation, treatment decision making, and surveillance of appendiceal tumors. In this study, we aimed to determine the prognostic significance of elevated preoperative tumor markers in patients with pseudomyxoma peritonei secondary to low-grade appendiceal mucinous neoplasm who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
METHODS: Using a multi-institutional database, eligible patients with measured preoperative tumor markers [carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), or cancer antigen 125 (CA-125)] were identified. Univariate and multivariate Cox-proportional hazards regression analysis assessed relationships between normal and elevated serum tumor markers with progression-free and overall survival in the context of multiple clinicopathologic variables.
RESULTS: zTwo hundred and sixty-four patients met criteria. CEA was the most commonly measured tumor marker (97%). Patients who had any elevated tumor marker had a higher peritoneal carcinomatosis index (PCI) as compared to those with normal range markers. Elevated CEA and CA 19-9 levels were individually associated with longer inpatient length of stay, requirement for intraoperative transfusion, and incomplete cytoreduction. Utilization of neoadjuvant chemotherapy, increased PCI score, elevated CA 19-9 (p = 0.007), and CA-125 levels (p = 0.01) were predictive of decreased progression-free survival on univariate analysis. However, in a multivariate model, only elevated PCI was a statistically significant predictor of progression-free survival.
CONCLUSION: Elevated preoperative tumor markers indicate a higher burden of disease but are not independently associated with survival in this retrospective multi-institutional cohort. Further prospective studies are needed to clarify the utility of these markers in this patient population.
PMID:34506026 | DOI:10.1007/s11605-021-05075-1
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Long-term Results of Low Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Analysis of 24 Patients
Fetched: September 8th, 2021, 5:02am GMT by Mustafa Gok
Arch Iran Med. 2021 Aug 1;24(8):615-621. doi: 10.34172/aim.2021.87.
ABSTRACT
BACKGROUND: Appendix tumors are rare tumors found in the gastrointestinal tract, observed at a rate of about 0.2%-0.3%. Our aim in this study was to present the clinicopathological classification, treatment and long-term prognosis of patients with low grade appendiceal mucinous neoplasm (LAMN).
METHODS: Patients who underwent surgery in the Erciyes University Department of (Kayseri, Turkey), Department of General Surgery between December 2010 and December 2018, and who had LAMN as a result of pathology were included in our study. Demographic data, clinical and pathological features of the disease, their treatment and follow-up results after treatment were reviewed retrospectively.
RESULTS: We included 24 patients in the study. Of these patients, 10 (41.6%) were male. The mean age distribution was 56.4 ± 20.3 (21-91) years. Appendectomy was performed in 14 patients, and additional organ resections were performed in 8 patients. The most common symptom at the time of presentation was abdominal pain (79.1%; 95% CI, 58.3-91.7). The most common preliminary diagnosis in the preoperative period was acute appendicitis (50%; 95% CI, 29.2-70.8). Mean postoperative hospitalization time was 7.4 ± 7.96 (2-31) days. On pathological examination, appendectomy resection margins were positive in two patients. The mean (median) postoperative follow-up was 31.25 ± 23.9 (27) (1-90) months. One-year survival was 91.6%, and 5-year survival was 83.3%. Recurrence was detected in three patients during the follow-up period.
CONCLUSION: If appendix mucinous neoplasia (AMN) is suspected in patients undergoing surgery with an initial diagnosis of acute or plastron appendicitis, care should be taken to remove the lesion without perforation. Pseudomyxomaperitonei, which may develop as a result of perforation, is associated with recurrence and decreased survival.
PMID:34488329 | DOI:10.34172/aim.2021.87
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Nomogram to Predict Incomplete Cytoreduction for Pseudomyxoma Peritonei
Fetched: September 5th, 2021, 5:01am GMT by Mingjian Bai
Ann Surg Oncol. 2021 Sep 3. doi: 10.1245/s10434-021-10725-4. Online ahead of print.
ABSTRACT
BACKGROUNDS: The completeness of cytoreduction is one of the most important prognostic factors for patients with pseudomyxoma peritonei (PMP). To date, no nomograms have been established to predict incomplete cytoreduction (IC) for patients with PMP. The current study therefore proposed a nomogram to predict individual IC risk for PMP patients.
METHODS: Between 1 June 2013, and 22 November 2019, 144 consecutive PMP patients who underwent cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for the first time in our center were included in a retrospective study. Possible predictors of cytoreducibility were analyzed using logistic regression modeling to predict IC for PMP patients. A nomogram was developed based on the multivariate analysis and further investigated for internal validation.
RESULTS: After CRS, the 144 participants were divided into complete CRS (CCRS) (n = 46) and IC (n = 98) subgroups. Four independent predictors (sex, disease duration, anemia, and carbohydrate antigen 19-9 (CA 199)) were included in the prediction model. Then, a nomogram predicting IC was established based on the aforementioned variables, which demonstrated good predictive accuracy (C-index, 0.837; 95 % confidence interval [CI], 0.764-0.894). The predicted probability was close to the actual observed outcome according to the calibration plot.
CONCLUSIONS: The current work led to the development of a nomogram capable of predicting IC for PMP patients who demonstrated good performance. Risk stratification by the established nomogram had ability to optimize individual IC prediction and help physicians to establish meticulous preoperative plans.
PMID:34480280 | DOI:10.1245/s10434-021-10725-4
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Appendiceal mucocele - a radiologists view
Fetched: September 2nd, 2021, 5:02am GMT by V Válek
Rozhl Chir. 2021 Summer;100(6):266-270. doi: 10.33699/PIS.2021.100.6.266-270.
ABSTRACT
Appendiceal mucocele is an obstructive dilatation of the appendix, which results from the filling of its lumen with mucus. This is a rare condition that is asymptomatic in half of the patients. Its severity depends on the cause of appendiceal dilatation. In a small percentage of cases, the dilated appendix ruptures, leading to the development of serious complication; this is termed as pseudomyxoma peritonei. Due to the possibility of malignant etiology of the mucocele, surgical resection remains an essential part of the treatment.
PMID:34465115 | DOI:10.33699/PIS.2021.100.6.266-270
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Statistical Analysis of Ultrasonic Scattered Echoes Enables the Non-invasive Measurement of Temperature Elevations inside Tumor Tissue during Oncological Hyperthermia
Fetched: August 29th, 2021, 5:01am GMT by Michio Takeuchi
Ultrasound Med Biol. 2021 Aug 23:S0301-5629(21)00334-3. doi: 10.1016/j.ultrasmedbio.2021.07.019. Online ahead of print.
ABSTRACT
Non-invasive monitoring of temperature elevations inside tumor tissue is imperative for the oncological thermotherapy known as hyperthermia. In the present study, two cancer patients, one with a developing right renal cell carcinoma and the other with pseudomyxoma peritonei, underwent hyperthermia. The two patients were irradiated with radiofrequency current for 40 min during hyperthermia. We report the results of our clinical trial study in which the temperature increases inside the tumor tissues of patients with right renal cell carcinoma and pseudomyxoma peritonei induced by radiofrequency current irradiation for 40 min could be detected by statistical analysis of ultrasonic scattered echoes. The Nakagami shape parameter m varies depending on the temperature of the medium. We calculated the Nakagami shape parameter m by statistical analysis of the ultrasonic echoes scattered from the tumor tissues. The temperature elevations inside the tumor tissues were expressed as increases in brightness on 2-D hot-scale maps of the specific parameter αmod, indicating the absolute values of the percentage changes in m values. In the αmod map for each tumor tissue, the brightness clearly increased with treatment time. In quantitative analysis, the mean values of αmod were calculated. The mean value of αmod for the right renal cell carcinoma increased to 1.35 dB with increasing treatment time, and the mean value of αmod for pseudomyxoma peritonei increased to 1.74 with treatment time. The increase in both αmod brightness and the mean value of αmod implied temperature elevations inside the tumor tissues induced by the radiofrequency current; thus, the acoustic method is promising for monitoring temperature elevations inside tumor tissues during hyperthermia.
PMID:34446333 | DOI:10.1016/j.ultrasmedbio.2021.07.019
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Hepatic tuberculosis: myriad of hues
Fetched: August 24th, 2021, 5:03am GMT by Arup Choudhury
Germs. 2021 Jun 2;11(2):310-313. doi: 10.18683/germs.2021.1266. eCollection 2021 Jun.
ABSTRACT
INTRODUCTION: Gastrointestinal tuberculosis is an important form of extrapulmonary tuberculosis but liver involvement is uncommon. Hepatic tuberculosis can manifest in variable manners including as a space occupying lesion, diffuse infiltration by granulomas (granulomatous hepatitis) and as liver abscess. Hepatic tuberculosis is usually associated with lesions elsewhere but the diagnosis is often not considered because of rarity.
CASE REPORT: We report two cases of hepatic involvement by tuberculosis: one in the form of liver abscess and the other having multiple hypodense hepatic lesions along with peritoneal involvement. The presence of ascites, visceral scalloping and multiple hypodense lesions resulted in a diagnostic confusion with disseminated malignancy but GeneXpert Ultra (Cepheid, USA) helped in making the diagnosis.
DISCUSSION: Hepatic tuberculosis should be considered in the differential diagnosis of hepatic space occupying lesions and abscesses. This is especially important in TB endemic regions and in patients where there is involvement of other organs especially the lungs.
CONCLUSIONS: Newer microbiological modalities including GeneXpert Ultra could help in making a diagnosis of hepatic tuberculosis.
PMID:34422701 | PMC:PMC8373414 | DOI:10.18683/germs.2021.1266
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Blood Flow and Shear Stress Allow Monitoring of Progression and Prognosis of Tumor Diseases
Fetched: August 22nd, 2021, 5:01am GMT by Matthias Barral
Front Physiol. 2021 Aug 3;12:693052. doi: 10.3389/fphys.2021.693052. eCollection 2021.
ABSTRACT
In the presence of tumor angiogenesis, blood flow must increase, leading to an elevation of blood flow velocities (BFVels) and wall shear stress (WSS) in upstream native arteries. An adaptive arterial remodeling is stimulated, whose purpose lies in the enlargement of the arterial inner diameter, aiming for normalization of BFVels and WSS. Remodeling engages delayed processes that are efficient only several weeks/months after initiation, independent from those governing expansion of the neovascular network. Therefore, during tumor expansion, there is a time interval during which elevation of BFVels and WSS could reflect disease progression. Conversely, during the period of stability, BFVels and WSS drop back to normal values due to the achievement of remodeling processes. Ovarian peritoneal carcinomatosis (OPC), pseudomyxoma peritonei (PMP), and superficial arteriovenous malformations (AVMs) are diseases characterized by the development of abnormal vascular networks developed on native ones. In OPC and PMP, preoperative blood flow in the superior mesenteric artery (SMA) correlated with the per-operative peritoneal carcinomatosis index (OPC: n = 21, R = 0.79, p < 0.0001, PMP: n = 66, R = 0.63, p < 0.0001). Moreover, 1 year after surgery, WSS in the SMA helped in distinguishing patients with PMP from those without disease progression [ROC-curve analysis, AUC = 0.978 (0.902-0.999), p < 0.0001, sensitivity: 100.0%, specificity: 93.5%, cutoff: 12.1 dynes/cm2]. Similarly, WSS in the ipsilateral afferent arteries close to the lesion distinguished stable from progressive AVM [ROC-curve analysis, AUC: 0.988, (0.919-1.000), p < 0.0001, sensitivity: 93.5%, specificity: 95.7%; cutoff: 26.5 dynes/cm2]. Blood flow volume is indicative of the tumor burden in OPC and PMP, and WSS represents an early sensitive and specific vascular marker of disease progression in PMP and AVM.
PMID:34413786 | PMC:PMC8369886 | DOI:10.3389/fphys.2021.693052
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Pseudomyxoma Peritonei
Fetched: August 22nd, 2021, 5:01am GMT by Bo Yu
2021 Aug 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–.
ABSTRACT
Pseudomyxoma peritonei (PMP) is a rare clinical entity, characterized by diffuse intra-abdominal gelatinous ascites, the so-called “jelly belly,” with mucinous implants on peritoneal surfaces. Werth first introduced the term pseudomyxoma peritonei in 1884. It was initially believed to arise from a perforated cystadenoma of the appendix. However, currently, it has been more widely used to describe peritoneal dissemination of mucus-producing neoplasm most frequently from the appendix, but also small and large bowel, stomach, pancreas, lung, breast, gallbladder, fallopian tubes, and ovaries. Due to its indolent behavior, pseudomyxoma peritonei is often discovered incidentally with a relatively advanced stage during laparoscopy, laparotomy or imaging studies for other medical concerns. Pseudomyxoma peritonei merits consideration as a ‘borderline malignancy’ with changing prognosis based on the site of origin.
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How to do hyperthermic intrathoracic chemotherapy for thoracic pseudomyxoma peritonei
Fetched: August 17th, 2021, 5:02am GMT by Varun J Sharma
ANZ J Surg. 2021 Aug 16. doi: 10.1111/ans.17134. Online ahead of print.
NO ABSTRACT
PMID:34396656 | DOI:10.1111/ans.17134
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Defining stage in mucinous tumours of the appendix with peritoneal dissemination: the importance of grading terminology: systematic review
Fetched: August 7th, 2021, 5:01am GMT by L Martín-Román
BJS Open. 2021 Jul 6;5(4):zrab059. doi: 10.1093/bjsopen/zrab059.
ABSTRACT
BACKGROUND: Mucinous appendiceal neoplasms with peritoneal dissemination (PD) show a wide spectrum of clinical behaviour. Histological grade has been correlated with prognosis, but no universally accepted histological grading has been established. The aim of this systematic review was to provide historical insight to understand current grading classifications, basic histopathological features of each category, and to define which classification correlates best with prognosis.
METHODS: MEDLINE and the Cochrane Library were searched for studies that reported survival across different pathological grades in patients with mucinous neoplasm of the appendix with PD treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. PRISMA guidelines were followed.
RESULTS: Thirty-eight studies were included. Ronnett's classification was the most common (9 studies). Classifications proposed by the Peritoneal Surface Oncology Group International (PSOGI) (6 studies) and the seventh or eighth edition of the AJCC (7 studies) are gaining in popularity. Nine studies supported a two-tier, 12 a three-tier, and two a four-tier classification system. Three studies demonstrated that acellular mucin had a better prognosis than low-grade pseudomyxoma peritonei in the PSOGI classification or M1bG1 in the eighth edition of the AJCC classification. Four studies demonstrated that the presence of signet ring cells was associated with a worse outcome than high-grade pseudomyxoma peritonei in the PSOGI classification and M1bG2 in the eighth edition of the AJCC.
CONCLUSION: There is a great need for a common language in describing mucinous neoplasms of the appendix with PD. Evolution in terminology as a result of pathological insight turns the four-tiered PSOGI classification system into a coherent classification option.
PMID:34355239 | PMC:PMC8342933 | DOI:10.1093/bjsopen/zrab059
Trial - Pseudomyxoma Peritonei
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Nivolumab and Ipilimumab in Treating Patients With Rare Tumors
Posted: July 15th, 2016, 2:00pm GMT
Conditions: Acinar Cell Carcinoma; Adenoid Cystic Carcinoma; Adrenal Cortex Carcinoma; Adrenal Gland Pheochromocytoma; Anal Canal Neuroendocrine Carcinoma; Anal Canal Undifferentiated Carcinoma; Angiosarcoma; Apocrine Neoplasm; Appendix Mucinous Adenocarcinoma; Bartholin Gland Transitional Cell Carcinoma; Basal Cell Carcinoma; Bladder Adenocarcinoma; Breast Metaplastic Carcinoma; Cervical Adenocarcinoma; Cholangiocarcinoma; Chordoma; Colorectal Squamous Cell Carcinoma; Desmoid Fibromatosis; Endometrial Transitional Cell Carcinoma; Endometrioid Adenocarcinoma; Esophageal Neuroendocrine Carcinoma; Esophageal Undifferentiated Carcinoma; Extrahepatic Bile Duct Carcinoma; Extramammary Paget Disease; Fallopian Tube Adenocarcinoma; Fallopian Tube Transitional Cell Carcinoma; Fibromyxoid Tumor; Gallbladder Carcinoma; Gastric Neuroendocrine Carcinoma; Gastric Squamous Cell Carcinoma; Gastric Undifferentiated Carcinoma; Gastrointestinal Stromal Tumor; Gestational Trophoblastic Tumor; Giant Cell Carcinoma; Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type; Intestinal Neuroendocrine Carcinoma; Intrahepatic Cholangiocarcinoma; Lung Carcinoid Tumor; Lung Sarcomatoid Carcinoma; Major Salivary Gland Carcinoma; Malignant Odontogenic Neoplasm; Malignant Peripheral Nerve Sheath Tumor; Malignant Solid Neoplasm; Malignant Testicular Sex Cord-Stromal Tumor; Metastatic Malignant Neoplasm of Unknown Primary; Minimally Invasive Lung Adenocarcinoma; Mixed Mesodermal (Mullerian) Tumor; Mucinous Adenocarcinoma; Mucinous Cystadenocarcinoma; Nasal Cavity Adenocarcinoma; Nasal Cavity Carcinoma; Nasopharyngeal Carcinoma; Nasopharyngeal Papillary Adenocarcinoma; Nasopharyngeal Undifferentiated Carcinoma; Oral Cavity Carcinoma; Oropharyngeal Undifferentiated Carcinoma; Ovarian Adenocarcinoma; Ovarian Germ Cell Tumor; Ovarian Mucinous Adenocarcinoma; Ovarian Squamous Cell Carcinoma; Ovarian Transitional Cell Carcinoma; Pancreatic Acinar Cell Carcinoma; Pancreatic Neuroendocrine Carcinoma; Paraganglioma; Paranasal Sinus Adenocarcinoma; Paranasal Sinus Carcinoma; Parathyroid Gland Carcinoma; PEComa; Peritoneal Mesothelioma; Pituitary Gland Carcinoma; Placental Choriocarcinoma; Primary Peritoneal High Grade Serous Adenocarcinoma; Pseudomyxoma Peritonei; Rare Disorder; Scrotal Squamous Cell Carcinoma; Seminal Vesicle Adenocarcinoma; Seminoma; Serous Cystadenocarcinoma; Small Intestinal Adenocarcinoma; Small Intestinal Squamous Cell Carcinoma; Spindle Cell Neoplasm; Squamous Cell Carcinoma of the Penis; Teratoma With Somatic-Type Malignancy; Testicular Non-Seminomatous Germ Cell Tumor; Thyroid Gland Carcinoma; Tracheal Carcinoma; Transitional Cell Carcinoma; Ureter Adenocarcinoma; Ureter Squamous Cell Carcinoma; Urethral Adenocarcinoma; Urethral Squamous Cell Carcinoma; Vaginal Adenocarcinoma; Vaginal Squamous Cell Carcinoma, Not Otherwise Specified; Vulvar Carcinoma
Interventions: Procedure: Biospecimen Collection; Biological: Ipilimumab; Biological: Nivolumab
Sponsor: National Cancer Institute (NCI)
Recruiting
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