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PubMed - Acinar Cell Carcinoma (13 unread)

Pancreatic panniculitis associated with acinar cell pancreatic carcinoma.

Fetched: May 14th, 2008, 9:00pm EDT

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Pancreatic panniculitis associated with acinar cell pancreatic carcinoma.

J Cutan Med Surg. 2008 Jan-Feb;12(1):38-42

Authors: Poelman SM, Nguyen K

BACKGROUND: Pancreatic panniculitis is a rare entity, occurring in less than 2% of patients with pancreatic disorders. Skin manifestations may precede the diagnosis of a pancreatic disease by many months. When treatable, correction of the underlying pancreatic disorder may lead to prompt resolution of the panniculitis. OBJECTIVE: We present the case of a 74-year-old-man with a history of chronic pancreatitis who presented with an acute onset of tender, nonulcerating nodules. The clinical and histologic features of pancreatic panniculitis are discussed, with a brief review of the differential diagnosis and clinical approach to panniculitis. CONCLUSIONS: Pancreatic panniculitis is a recognizable clinical entity with characteristic histologic features that may resolve with treatment of the underlying pancreatic disorder. The algorithm-based clinical approach to panniculitis presented in this study is a practical tool designed to guide clinicians in ordering investigations and determining the appropriate management for patients presenting with subcutaneous nodules.

PMID: 18258147 [PubMed - indexed for MEDLINE]
Current diagnosis and management of unusual pancreatic tumors.

Fetched: May 10th, 2008, 9:00pm EDT

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Current diagnosis and management of unusual pancreatic tumors.

Am J Surg. 2008 May 6;

Authors: Mortenson MM, Katz MH, Tamm EP, Bhutani MS, Wang H, Evans DB, Fleming JB

BACKGROUND: The finding of a solid or cystic mass in the pancreas is becoming more common secondary to the increasing use of cross-sectional imaging and the improved sensitivity of such studies for the detection of pancreatic abnormalities. Because of the aggressive natural history of pancreatic cancer, this has caused concern that all pancreatic abnormalities may be cancer as well as confusion over proper diagnostic and treatment algorithms. This review provides an overview of the natural history, diagnostic considerations, and treatment recommendations for the less common tumors of the pancreas which can be misinterpreted as pancreatic cancer including: solid pseudopapillary tumors (SPT), acinar cell carcinoma (ACC), lymphoplasmacytic sclerosing pancreatitis (LPSP), primary pancreatic lymphoma (PPL), and metastatic renal cell carcinoma to the pancreas. DATA SOURCES: A Medline search was conducted to identify studies investigating the clinicopathologic features, molecular genetics, pathogenesis, diagnosis, and treatment of SPT, ACC, LPSP, PPL, and pancreatic metastases. CONCLUSIONS: It is often possible to obtain an accurate pretreatment diagnosis for these unusual pancreatic tumors and to successfully differentiate them from the more common pancreatic malignancies.

PMID: 18466869 [PubMed - as supplied by publisher]
Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours.

Fetched: May 6th, 2008, 9:00pm EDT

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Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours.

J Oral Pathol Med. 2008 May;37(5):309-18

Authors: Vargas PA, Cheng Y, Barrett AW, Craig GT, Speight PM

BACKGROUND: Recent studies have proposed that minichromosome maintenance (Mcm) proteins may be sensitive proliferation markers and may serve as novel biomarkers for prognostication and diagnosis of various pre-malignant and malignant lesions. The aims of this study were to determine the expression of Mcm-2, Ki-67 and geminin in salivary gland (SG) tumours, and to evaluate their usefulness for diagnosis or for prediction of tumour behaviour. METHODS: Tissue from 62 SG tumours was assembled in tissue microarray format. There were 13 adenoid cystic carcinomas (ACC), 10 carcinoma ex pleomorphic adenomas (CEPA), 10 mucoepidermoid carcinomas (MEC), 10 polymorphous low-grade adenocarcinomas (PLGA), 10 pleomorphic adenomas (PA) and nine acinic cell carcinomas (AcCC). Clinicopathological data were collected retrospectively and immunohistochemical analyses of Mcm-2, Ki-67 and geminin were performed on all lesions. Labelling index (LI) for each marker was determined by counting the percentage of positive cells in six random fields from three arrays per case. RESULTS: Mcm-2 expression was higher than Ki-67 and geminin in all tumours studied. Mcm-2 LI was higher in ACC (28.2 +/- 19.2%) than in CEPA, AcCC, MEC, PA and PLGA (5.3 +/- 4.1%, P = 0.001). Mcm-2 LI was higher in CEPA (20.4 +/- 5.0%) than in PA (6.9 +/- 5.0%, P = 0.001). LI did not correlate to tumour grade or outcome for any of the markers or tumour types. CONCLUSIONS: The findings suggest that Mcm-2 may be a sensitive proliferation marker in SG tumours and may be useful for differential diagnosis between PA and CEPA, and ACC and PLGA. Further studies are warranted to assess the value of Mcm-2 as a predictor of recurrence and survival.

PMID: 18248354 [PubMed - indexed for MEDLINE]
Carcinomatous encephalitis as clinical presentation of occult lung adenocarcinoma: case report.

Fetched: May 2nd, 2008, 9:00pm EDT

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Carcinomatous encephalitis as clinical presentation of occult lung adenocarcinoma: case report.

Arq Neuropsiquiatr. 2007 Sep;65(3B):841-4

Authors: Ribeiro HB, Paiva TF, Mamprin GP, Gorzoni ML, Rocha AJ, Lancellotti CL

Carcinomatous encephalitis is a rare entity, originally described by Madow and Alpers in 1951, which is characterized by tumoral spreading perivascular, without mass effect. Clinical manifestations such as hemiparesis, seizures, ataxia, speech difficulties, cerebrospinal fluid findings as well as computed tomography are nonspecific. This leads the physician to pursue more frequent diseases that could explain those manifestations--toxic, metabolic, and/or infectious encephalopathy. A magnetic resonance imaging (MRI) with gadolinium, the method of choice, presumes the diagnosis. Previous reports of this unusual form of metastatic disease have described patients with prior diagnosis of pulmonary adenocarcinoma. We present the case of carcinomatous encephalitis in a 76-year-old woman as the primary manifestation of occult pulmonary adenocarcinoma with its clinical, imaging, and anatomopathological findings.

PMID: 17952293 [PubMed - indexed for MEDLINE]
[Acinar cell carcinoma of the pancreas: A rare tumor with particular clinical and paraclinical presentation.]

Fetched: April 25th, 2008, 9:00pm EDT

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[Acinar cell carcinoma of the pancreas: A rare tumor with particular clinical and paraclinical presentation.]

Rev Med Interne. 2008 Apr 21;

Authors: Sabbagh C, Fuks D, Chatelain D, Flamant M, Delcenserie R, Yzet T, Regimbeau JM

Acinar cell carcinoma of the pancreas is a rare tumour with specific clinical and paraclinical presentation. Its management is not well codified resulting from its low frequency.

PMID: 18433943 [PubMed - as supplied by publisher]
Necrotizing Panniculitis: A Skin Condition Associated with Acinar Cell Carcinoma of the Pancreas.

Fetched: April 17th, 2008, 9:00pm EDT

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Necrotizing Panniculitis: A Skin Condition Associated with Acinar Cell Carcinoma of the Pancreas.

South Med J. 2008 Apr 10;

Authors: Lakhani A, Maas L

Pancreatic panniculitis (PP) is a rare cutaneous eruption that is associated with severe pancreatic disease. A patient presented with a fever, joint pains, and an erythematous rash with draining pustules that had spread from his legs to his arms over 4 months. Thorough investigation revealed stage IV acinar cell carcinoma of the pancreas. The rash was a result of necrotizing PP. The variable cutaneous manifestations of internal malignancies may challenge primary care physicians and dermatologists when patients present without findings associated with malignancy. Panniculitis should be kept in mind in the differential diagnosis of inflamed appearing nodules and pustules with an erythematous base, particularly when they are progressive and unrelenting.

PMID: 18414166 [PubMed - as supplied by publisher]
Elevated alpha-fetoprotein and a pancreatic tumour.

Fetched: March 29th, 2008, 9:00pm EDT

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Elevated alpha-fetoprotein and a pancreatic tumour.

Gut. 2008 Apr;57(4):434, 462

Authors: Liu KL, Teng YC, Tien YW, Lin JT

PMID: 18334655 [PubMed - indexed for MEDLINE]
Pancreatic acinar cell carcinoma presenting as acute pancreatitis.

Fetched: March 12th, 2008, 9:00pm EDT

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Pancreatic acinar cell carcinoma presenting as acute pancreatitis.

HPB (Oxford). 2003;5(2):111-3

Authors: Thomas P, Nash G, Aldridge M

BackgroundAcinar cell carcinoma (ACC) is a rare pancreatic neoplasm, and its presentation with acute pancreatitis has not been reported previously.Case outlineA 70-year-old man presented with acute pancreatitis, and a spiral CT scan showed a 5-cm tumour in the body of the pancreas. Distal pancreatectomy was performed, and histological examination showed an ACC.DiscussionThis is a newly reported mode of presentation for a rare pancreatic tumour.

PMID: 18332967 [PubMed - in process]
Acinar cell carcinoma of the pancreas with and without endocrine differentiation.

Fetched: March 12th, 2008, 9:00pm EDT

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Acinar cell carcinoma of the pancreas with and without endocrine differentiation.

HPB (Oxford). 2002;4(2):87-90

Authors: Virlos I, Papazachariou I, Wiliamson R

BackgroundAcinar cell carcinoma (ACC) is a rare pancreatic neoplasm, representing 1% of exocrine tumours and containing a variable endocrine component. Three recent cases of ACC are reported.Case outlinesA 72-year-old man with painless obstructive jaundice had a 5-cm mass in the head of pancreas resected by Whipple's operation; histopathological examination showed a typical ACC. A 33-year-old man with weight loss and abnormal liver function had a dilated biliary tree but no mass on imaging. Pylorus-preserving pancreatoduodenectomy was performed, and histology showed a mixed acinar-neuro-endocrine tumour. A 56-year-old man with weight loss and a palpable mass had a 15-cm mass in the distal body of pancreas, which was resected en bloc with the spleen and adherent stomach; it was a cystic ACC.ResultsTwo patients are alive and free of disease at 30 months and 15 months, while the third patient with locally advanced disease died of myocardial infarction at 9 weeks.DiscussionAcinar structures are the hallmark of this neoplasm, which carries a better survival rate than ductal cancer. Surgical excision prolongs survival and offers the best chance of cure.

PMID: 18332930 [PubMed - in process]
Gefitinib prevents cancer progression in mice expressing the activated rat HER2/neu.

Fetched: March 7th, 2008, 9:00pm EST

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Gefitinib prevents cancer progression in mice expressing the activated rat HER2/neu.

Int J Cancer. 2008 Apr 15;122(8):1722-9

Authors: Piechocki MP, Dibbley SK, Lonardo F, Yoo GH

We tested the efficacy of gefitinib in the prevention of HER2/neu-mediated breast cancer development in BALB-NeuT transgenic mice. Oral administration of gefitinib to female transgenic mice from 5 to 14 weeks of age reduced tumor multiplicity from 9.6 +/- 0.82 to 0.58 +/- 1.1 (83%). We observed a decrease in the number and size of lobules and lobular nodules in treated mice with a reduction in the overall disease burden per gland. Normal duct development in the mammary glands was not affected by gefitinib. The development of acinic cell carcinoma in the parotid glands of these animals was also reduced coincident with decreased stromal involvement during progression. Gefitinib eliminated phosphorylation of HER2 and HER3 and signaling through MAPK and Akt in lobular hyperplasias and carcinomas. At the same time MAPK activity and cytokine production in splenocytes and lymph nodes was increased in gefitinib-treated animals coincident with an increase in lymph node size. Delaying gefitinib treatment until mammary glands exhibited atypical lobular hyperplasias reduced efficacy. These studies demonstrate the critical role of HER2 signal transduction in the onset and progression of HER2/neu-dependent breast cancer and suggest a role for specific inhibitors to prevent the outgrowth of early hyperplastic disease.

PMID: 18076070 [PubMed - indexed for MEDLINE]
Metastatic acinic cell carcinoma presenting as a recurrent pituitary adenoma.

Fetched: February 22nd, 2008, 9:00pm EST

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Metastatic acinic cell carcinoma presenting as a recurrent pituitary adenoma.

J Otolaryngol. 2007 Dec;36(6):E91-2

Authors: Thomason T, Oxford LE, Ducic Y

PMID: 18076836 [PubMed - indexed for MEDLINE]
Acinic cell carcinoma of the submandibular salivary gland presenting as a large cyst.

Fetched: February 20th, 2008, 9:00pm EST

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Acinic cell carcinoma of the submandibular salivary gland presenting as a large cyst.

Int J Oral Maxillofac Surg. 2007 Dec;36(12):1215-7

Authors: Chidzonga MM, Makunike-Mutasa R

Acinic cell carcinomas are rare tumours of salivary gland origin, most commonly seen in middle-aged women and predominantly in the parotid gland. The case of a long-standing, predominantly cystic, acinic cell carcinoma located in the submandibular gland of a child is presented here. The tumour was successfully removed and there has been no recurrence.

PMID: 17629459 [PubMed - indexed for MEDLINE]
Central Pancreatectomy: Single-Center Experience of 50 Cases.

Fetched: February 20th, 2008, 9:00pm EST

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Central pancreatectomy: single-center experience of 50 cases.

Arch Surg. 2008 Feb;143(2):175-80; discussion 180-1

Authors: Adham M, Giunippero A, Hervieu V, Courbière M, Partensky C

Central pancreatectomy is a nonstandard operation for unusual lesions. This study reports a single-center experience of central pancreatectomy. Thirty-eight women and 12 men with a mean age of 49.4 years (range, 13.4-79.2 years) underwent central pancreatectomy from January 1987 to October 2005. Indications included 18 neuroendocrine tumors (11 nonfunctioning), 10 serous and 10 mucinous cystadenomas, 5 intraductal papillary mucinous neoplasms, 3 main pancreatic duct strictures, 2 solid cystic papillary tumors, 1 hydatid cyst, and 1 acinar cell carcinoma. The proximal pancreatic remnant was suture ligated. The distal pancreatic end was anastomosed to a Roux-en-Y jejunal loop (n = 6) or to the stomach (n = 44). Three patients had associated procedures, 1 each for metastatic liver cytoreduction (VIPoma), hydatid liver disease, and pancreatic resection for multifocal mucinous cystadenoma. The median operative time was 3 hours 21 minutes (range, 1 hour 50 minutes to 6 hours). The mean length of the resected pancreas was 45 mm (range, 20-80 mm) and the mean tumor size was 23 mm (5-60 mm). The perioperative mortality was nil. Complications included the following: 4 patients (8%) had pancreatic anastomotic leak, 5 patients (10%) had acute pancreatitis, 7 patients (14%) had intra-abdominal collection, and 3 patients (6%) had bleeding. Six patients (12%) required a reoperation during the postoperative period. Eight patients (16%) required endoscopic (1 with biliary endoscopic stent) or radiological (7 with percutaneous drainage) intervention. No patients developed de novo diabetes. On long-term follow-up, 2 patients with invasive intraductal papillary mucinous neoplasia had recurrence; one was treated successfully by completion pancreatectomy and the other died at 20 months. One patient with serous cystadenoma died at 16.8 years without recurrence. One patient with metastatic VIPoma had a liver transplant 9 years postoperatively and is alive. The median follow-up was 55 months (range, 2 months to 16.8 years). The actuarial 5-year patient and pancreatic remnant survival rates were 98% and 95%, respectively. In our series, central pancreatectomy led to effective preservation of both cephalic and distal pancreatic remnants without a significant increase in postoperative morbidity compared with conventional pancreatectomy.

PMID: 18283143 [PubMed - in process]