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Anaplastic Kaposi sarcoma resembling epithelioid angiosarcoma in an HIV-positive man.
Eur J Dermatol. 2008 May 13;18(3):358-359
Authors: Craddock KJ, Labonte S, Ghazarian D
PMID: 18474484 [PubMed - as supplied by publisher]
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PubMed - Angiosarcoma (50 unread)
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Anaplastic Kaposi sarcoma resembling epithelioid angiosarcoma in an HIV-positive man.
Fetched: May 14th, 2008, 9:00pm EDT
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Hepatic angiosarcoma manifested as recurrent hemoperitoneum.
Fetched: May 14th, 2008, 9:00pm EDT
Related Articles Hepatic angiosarcoma manifested as recurrent hemoperitoneum.
World J Gastroenterol. 2008 May 14;14(18):2935-8
Authors: Lee SW, Song CY, Gi YH, Kang SB, Kim YS, Nam SW, Lee DS, Kim JO
Angiosarcoma is a rare tumor that account for less than 1% of all sarcomas. Although hepatic angiosarcoma usually presents with unspecific symptoms, it rapidly progresses and has a high mortality. We report a rare case of primary hepatic angiosarcoma manifested as recurrent hemoperitoneum.
PMID: 18473427 [PubMed - in process]
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Primary aortic intimal sarcoma.
Fetched: May 13th, 2008, 9:00pm EDT
Related Articles Primary aortic intimal sarcoma.
Gen Thorac Cardiovasc Surg. 2008 May;56(5):236-8
Authors: Kato W, Usui A, Oshima H, Suzuki C, Kato K, Ueda Y
Aortic intimal angiosarcoma is extremely rare, and the prognosis of patients with a tumor is unfavorable even if they have undergone surgery. We treated a patient with primary intimal angiosarcoma of the aortic arch who underwent an operation. The tumor originated from the inner wall of the aortic arch on the lesser curve. In order to remove the tumor completely, the entire aortic arch from the ascending to the middle of descending aorta was resected through an L-shape skin incision. On histologic examination, an undifferentiated intimal sarcoma was diagnosed. It grew into the aortic lumen while spreading along the aortic intima, focally infiltrating the media. The postoperative course was uneventful. Postoperative CT performed at 6, 12 and 18 months after surgery showed no local recurrence or metastasis. According to some reports endoarterectomy has been performed to treat this type of tumor, since the malignant cells are thought to be limited to the luminal surface. However, we favor aortic resections and graft interpositions rather than an endoarterectomy because the tumor could have invaded the media.
PMID: 18470690 [PubMed - in process]
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Carcinogenic susceptibility of rasH2 mice to troglitazone.
Fetched: May 13th, 2008, 9:00pm EDT
Related Articles Carcinogenic susceptibility of rasH2 mice to troglitazone.
Arch Toxicol. 2007 Dec;81(12):883-94
Authors: Jin M, Takahashi M, Moto M, Muguruma M, Ito K, Watanabe K, Kenmochi Y, Kono T, Hasumi K, Mitsumori K
To evaluate the carcinogenicity of troglitazone in rasH2 mice, 7-week-old male and female rasH2 mice were fed a diet containing 0, 3,000 or 6,000 ppm troglitazone for 26 weeks. An increased tendency in the incidence of vascular tumors was observed in females of the 6,000 ppm group. The preliminary analysis using a high-density oligonucleotide microarray on a splenic hemangiosarcoma of a high dose female that could be obtained as a fresh sample showed that several genes related to the ras/MAPK pathway activation, angiogenesis, cell cycle and cell multiplication were up-regulated. In addition, most of the genes up-regulated were confirmed by the reverse transcriptase-polymerase chain reaction (RT-PCR). These results may suggest that the carcinogenic susceptibility of rasH2 mice to troglitazone is relatively low and up-regulations of the ras/MAPK pathway and angiogenesis-related genes are probably involved in the production of splenic hemangiosarcomas in rasH2 mice given troglitazone.
PMID: 17569031 [PubMed - indexed for MEDLINE]
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Primary hepatic sarcomas: CT findings.
Fetched: May 9th, 2008, 9:00pm EDT
Related Articles Primary hepatic sarcomas: CT findings.
Eur Radiol. 2008 May 8;
Authors: Yu RS, Chen Y, Jiang B, Wang LH, Xu XF
Primary hepatic sarcomas are rare tumors that are difficult to diagnose clinically. Different primary hepatic sarcomas may have different clinical, morphologic, and radiological features. In this pictorial review, we summarized computed tomography (CT) findings of some relatively common types of hepatic sarcomas, including angiosarcoma, epithelioid hemangioendothelioma (EHE), liposarcoma, undifferentiated embryonal sarcoma (UES), leiomyosarcoma, malignant fibrous histiocytoma (MFH), and carcinosarcoma (including cystadenocarcinosarcoma). To our knowledge, hepatic cystadenocarcinosarcoma has not been described in the English literature. The CT findings in our case are similar to that of cystadenocarcinoma, a huge, multilocular cystic mass with a large mural nodule and solid portion. The advent of CT has allowed earlier detection of primary hepatic sarcomas as well as more accurate diagnosis and characterization. In addition, we briefly discuss the MRI findings and diagnostic value of primary hepatic sarcomas.
PMID: 18463872 [PubMed - as supplied by publisher]
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Cutaneous angiosarcoma presenting as bilateral erythematous plaques on the face and neck.
Fetched: May 9th, 2008, 9:00pm EDT
Related Articles Cutaneous angiosarcoma presenting as bilateral erythematous plaques on the face and neck.
J Eur Acad Dermatol Venereol. 2008 May 1;
Authors: Ghalamkarpour F, Robati RM, Sarrafi-Rad N, Kavand S
PMID: 18462308 [PubMed - as supplied by publisher]
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Hepatic angiosarcoma with metastasis to small intestine.
Fetched: May 3rd, 2008, 9:00pm EDT
Related Articles Hepatic angiosarcoma with metastasis to small intestine.
J Coll Physicians Surg Pak. 2008 Jan;18(1):50-2
Authors: Ahmad Z, Nisa A, Idrees R, Minhas K, Pervez S, Mumtaz K
Hepatic angiosarcomas are rare tumours with poor prognosis, with patients usually dying within 6 months. Metastases mainly occur in lymph nodes, spleen, lungs, bones and adrenals. Metastasis to small intestine is even rarer. Similarly, primary or metastatic angiosarcomas in small intestine are extremely rare, often present with recurrent gastrointestinal bleeding and anemia, and have an extremely poor prognosis. Both primary or metastatic intestinal angiosarcomas may exhibit epithelioid morphology. It may be very difficult to differentiate between primary and secondary cases in intestine and especially when the tumour exhibits epithelioid morphology.
PMID: 18452671 [PubMed - in process]
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Primary mesenteric angiosarcoma in a child with associated lymphangectasia: a case report.
Fetched: May 3rd, 2008, 9:00pm EDT
Related Articles Primary mesenteric angiosarcoma in a child with associated lymphangectasia: a case report.
Pediatr Dev Pathol. 2008 May 1;:1
Authors: Costa da Cunha Castro E, Galambos C, Shaw P, Ranganathan S
Angiosarcomas are rare tumors in children, usually occurring in soft tissue and liver. By contrast, angiosarcoma in adults usually occurs in the extremities in conjunction with lymphedema. Mesenteric angiosarcoma has only rarely been reported. When angiosarcomas arise in this location, it is usually as a second malignancy following Hodgkin's lymphoma. We report a child who presented to the emergency room with a acute abdomen and underwent emergency surgery for a mesenteric angiosarcoma with associated lymphangectasia of the bowel and mesentery. A brief review of the literature and the nomenclature of these unusual tumors are discussed.
PMID: 18452347 [PubMed - as supplied by publisher]
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Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report.
Fetched: May 1st, 2008, 9:00pm EDT
Related Articles Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report.
J Med Case Reports. 2008 Apr 29;2(1):133
Authors: Manouras A, Giannopoulos P, Toufektzian L, Markogiannakis H, Lagoudianakis EE, Papadima A, Papanikolaou D, Filis K, Kekis P
ABSTRACT: INTRODUCTION: Primary splenic angiosarcoma is a rare neoplasm of vascular origin carrying a very poor prognosis, partly due to its high metastatic potential. This disease presents frequently with splenic rupture and hemorrhage. We report the case of a 17-year-old woman who presented with rupture of a primary splenic angiosarcoma. CASE PRESENTATION: The patient presented with diffuse abdominal pain and distention. Clinical examination revealed severe tenderness in the left upper abdominal quadrant, a palpable abdominal mass, and hemodynamic instability with a systolic arterial blood pressure of 75mmHg and heart rate of 135 beats per minute. Blood tests revealed anemia (hemoglobin 7.0g/dl) and thrombocytopenia (platelets 70x109/liter). After initial fluid resuscitation and stabilization, abdominal ultrasound and computed tomography were performed, revealing a large quantity of intraperitoneal free fluid, an enlarged spleen, and a heterogeneous low-density signal within the splenic parenchyma, which showed varying degrees of contrast enhancement. At laparotomy a huge (weight 1530g, diameter 19cm) actively bleeding spleen was identified and splenectomy was performed. Histopathology showed a primary splenic angiosarcoma. After an uneventful recovery, the patient was discharged on the sixth postoperative day. CONCLUSIONS: Primary splenic angiosarcoma is rare. Although this malignancy is usually encountered in advanced age, there have been a few reported cases among younger patients. The case reported here presented with splenic rupture, was treated by laparotomy and splenectomy, and the patient is disease free 16 months after surgery.
PMID: 18445294 [PubMed - as supplied by publisher]
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Hemangiosarcoma in a South American sea lion (Otaria byronia).
Fetched: April 25th, 2008, 9:00pm EDT
Related Articles Hemangiosarcoma in a South American sea lion (Otaria byronia).
J Zoo Wildl Med. 2008 Mar;39(1):118-20
Authors: You MH, Bae IH, Jee H, Yoo MJ, Shin NS, Kim DY
A 10-yr-old male South American sea lion (Otaria byronia) died after several weeks of depression, anorexia, weight loss, and progressive respiratory distress. At necropsy, three confluent, lobulated, dark-red masses were noted in the mesentery. Similar masses were also observed in the lung and both kidneys. Hemangiosarcoma was diagnosed based on gross findings, histopathology, and immunohistochemistry. This is the first case of hemangiosarcoma reported in pinnipeds.
PMID: 18432107 [PubMed - in process]
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FDG Uptake in Abdominal Mesh Implant on FDG PET/CT.
Fetched: April 24th, 2008, 9:00pm EDT
Related Articles FDG Uptake in Abdominal Mesh Implant on FDG PET/CT.
Clin Nucl Med. 2008 May;33(5):351-352
Authors: Yilmaz M, Sevinc A, Aybasti N, Celen Z, Zincirkeser S
A 50-year-old man with peritoneal angiosarcoma underwent total tumor excision along with removal of the total right rectus and medial part of the left rectus muscles 1 year earlier. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) was performed for suspected recurrence. In the anterior abdominal wall extensive subcutaneous FDG uptake showing linear hypermetabolic zone on PET slices was noted. The patient had a history of a dual mesh implant, which consists of polypropylene and polyvinylidene fluoride for the reinforcement of the abdominal wall during the operation. PET/CT fusion image demonstrated that the finding was due to the dual mesh implant in the anterior abdominal wall most likely representing a foreign body reaction.
PMID: 18431155 [PubMed - as supplied by publisher]
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Metastasis of mediastinal epithelioid angiosarcoma to the finger.
Fetched: April 24th, 2008, 9:00pm EDT
Related Articles Metastasis of mediastinal epithelioid angiosarcoma to the finger.
Am J Clin Dermatol. 2008;9(3):181-3
Authors: Chen TJ, Chiou CC, Chen CH, Kuo TT, Hong HS
Epithelioid angiosarcoma (EA) is a rare malignant, vascular tumor that is usually observed in middle-aged and elderly males. Cutaneous metastasis of EA is extremely rare. We report the case of a 41-year-old woman presenting with a painful bluish, bulla-like lesion on the distal extent of the left third finger. The patient had recently been diagnosed with mediastinal EA with disseminated metastases. The skin biopsy specimen revealed metastatic EA. This is thought to be the first reported metastasis of EA to the finger. Whenever a patient has metastatic disease, acrometastases should be considered in the differential diagnosis of inflammatory lesions of the digits and a skin biopsy should be performed.
PMID: 18429648 [PubMed - in process]
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Malignant primary cardiac tumors: review of a single institution experience.
Fetched: April 23rd, 2008, 9:00pm EDT
Related Articles Malignant primary cardiac tumors: review of a single institution experience.
Cancer. 2008 Apr 21;
Authors: Simpson L, Kumar SK, Okuno SH, Schaff HV, Porrata LF, Buckner JC, Moynihan TJ
BACKGROUND.: Primary cardiac sarcomas are uncommon. The authors undertook to review the Mayo Clinic's experience with primary cardiac sarcomas consisting of 34 patients seen over a 32-year period. METHODS.: The patient database at the Mayo Clinic was searched to identify patients with malignant tumors of the heart seen during the 32-year period between 1975 and 2007. Thirty-four patients with primary cardiac sarcomas were identified and their medical records reviewed for details pertaining to presenting symptoms, staging modalities, treatment approaches, and outcomes. RESULTS.: Of the 34 patients, 17 were men and 17 were women. The median age was 44 years. The mean duration of symptoms at the time of diagnosis was 3.6 months. The most common histologic type was angiosarcoma (41%). The median follow-up for the entire group was 12 months (range, 0-61 months). The median survival for those who underwent a complete surgical excision was 17 months compared with 6 months for those in whom a surgical complete remission could not be achieved (P = .01). Patients with angiosarcoma had a lower survival compared with patients with other histologies (5 months vs 17 months; P = .01). The median survival of patients with metastatic disease was 5 months versus 15 months in patients without metastatic disease (P = .03 by the log-rank test). CONCLUSIONS.: Cardiac sarcomas remain a rare but lethal disease. Compared with extracardiac sarcomas, the prognosis for patients with cardiac sarcomas remains very poor. A complete surgical excision should be performed if possible. Innovative treatment strategies are required. Cancer 2008. (c) 2008 American Cancer Society.
PMID: 18428209 [PubMed - as supplied by publisher]
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Extravascular papillary endothelial hyperplasia of the palm masquerading as an angiosarcoma.
Fetched: April 21st, 2008, 9:00pm EDT
Related Articles Extravascular papillary endothelial hyperplasia of the palm masquerading as an angiosarcoma.
J Dermatol. 2008 Apr;35(4):238-41
Authors: Arai E, Shimizu M, Ogawa F, Hirose T, Ohbayashi H, Taguchi S, Tsuchida T
Cutaneous extravascular papillary endothelial hyperplasia (PEH) is a rare lesion presenting as a cutaneous mass and histologically mimicking angiosarcoma. Herein, we describe a patient who presented with a palm tumor that had developed after trauma. Histologically, the lesion was ulcerated and showed proliferation of atypical epithelioid cells with nuclear enlargement and mitosis. Vascular proliferation was evident, and these were positive for CD31 and CD34, with approximately 20% positivity for MIB-1. We diagnosed this case as an extravascular papillary endothelial hyperplasia because there was no evidence of invasion into the surrounding tissue and elastica staining proved it did not have a vascular structure. To our knowledge, cutaneous extravascular PEH has not yet been reported in the published work.
PMID: 18419683 [PubMed - in process]
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Use of contrast-enhanced ultrasound for characterization of focal splenic lesions.
Fetched: April 21st, 2008, 9:00pm EDT
Related Articles Use of contrast-enhanced ultrasound for characterization of focal splenic lesions.
Vet Radiol Ultrasound. 2008 Mar-Apr;49(2):154-64
Authors: Rossi F, Leone VF, Vignoli M, Laddaga E, Terragni R
Contrast-enhanced ultrasound was used to study focal and multifocal lesions of the spleen in 26 dogs and two cats affected by 11 benign and 18 malignant splenic diseases. A second-generation microbubble contrast medium (Sonovue) was injected into the cephalic vein and enhancement patterns were subjectively described and time intensity curves calculated. Final diagnosis was obtained by histopathologic examination after splenectomy (n=19) or by needle aspiration and sonographic follow-up after 4 and 8 weeks (n=9). Contrast-enhanced ultrasound parameters, improving the characterization between benign and malignant lesions, were established. The most useful criterion was the hypoechogenicity of the lesion in the wash-out phase combined with the presence of tortuous feeding vessels, which was observed in association with malignancy. All malignant lesions were hypoechoic to the surrounding spleen 30s after starting the contrast medium injection. Lymphosarcoma and hemangiosarcoma had characteristic perfusion patterns. Lymphosarcoma had rapid time to peak and early wash-out phase with a honeycomb pattern during the wash-out. Hemangiosarcomas were large nonperfused masses in all phases surrounded by hypervascular splenic parenchyma. Benign lesions except one hematoma and a benign histiocytoma had the same perfusion pattern as the surrounding spleen. Ultrasonographic and contrast-enhanced ultrasound findings of an accessory spleen are reported. Contrast-enhanced ultrasound can improve the characterization of focal or multifocal lesions of the spleen.
PMID: 18418997 [PubMed - in process]
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Intravascular epithelioid hemangioendothelioma of the inferior vena cava: case report of an unusual and unpredictable vascular tumor.
Fetched: April 18th, 2008, 9:00pm EDT
Related Articles Intravascular epithelioid hemangioendothelioma of the inferior vena cava: case report of an unusual and unpredictable vascular tumor.
Cardiovasc Pathol. 2008 Apr 14;
Authors: Scordi-Bello IA, Snyder A, Schwartz M, Fallon JT
Vascular neoplasms are uncommon and pose a diagnostic and treatment challenge to the pathologist and surgeon, respectively. Epithelioid hemangioendothelioma is a rare neoplasm of vascular origin with an unknown etiology. Its biologic behavior lies somewhere between that of a benign hemangioma and that of a malignant angiosarcoma; however, it is unpredictable at best. Intravascular epithelioid hemangioendotheliomas have been described more often in veins than arteries, and there are only about 30 reports in the English literature. We report here the case of an epithelioid hemangioendothelioma of the inferior vena cava, which presented with abdominal pain, ascites and pedal edema.
PMID: 18417368 [PubMed - as supplied by publisher]
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Differential Expression of Decorin by Human Malignant and Benign Vascular Tumors.
Fetched: April 17th, 2008, 9:00pm EDT
Related Articles Differential Expression of Decorin by Human Malignant and Benign Vascular Tumors.
J Histochem Cytochem. 2008 Apr 14;
Authors: Salomäki HH, Sainio AO, Söderström M, Pakkanen S, Laine J, Järveläinen HT
An increasing amount of evidence is available indicating that a small extracellular chondroitin/dermatan sulphate proteoglycan decorin, is indirectly involved in angiogenesis. Given that angiogenesis is a sine qua non for tumor growth and progression, we attempted to examine whether human malignant vascular tumors differ from human benign vascular tumors in terms of their decorin expression and synthesis. CD31 immunostaining demonstrated that the human malignant vascular tumors Kaposis sarcoma and angiosarcoma were filled with capillary-like structures whereas in benign cavernous and capillary hemangiomas blood vessels were not as abundantly present. By utilising in situ hybridization and immunocytochemical assays for decorin, we showed that there was no detectable decorin mRNA expression or immunoreactivity within the tumor mass in the Kaposis sarcoma or angiosarcoma group. Instead, decorin was expressed in the connective tissue stroma lining the sarcoma tissue. In contrast to sarcomas, in hemangiomas decorin mRNA expression and immunoreactivity were observed also within the tumor mass, particularly in the connective tissue stroma surrounding the clusters of intratumoral blood vessels. Finally, distribution of type I collagen was found to be similar to that of decorin in these tumor tissues. Our findings can be explained with different states of angiogenesis in dissimilar growths. In sarcomas angiogenesis is extremely powerful whereas in hemangiomas angiogenesis has ceased. Thus, decorin is likely to possess a suppressive effect on human tumor angiogenesis in vivo, as previously described by studies using different experimental models. Decorin certainly provides a usable biomarker to distinguish between benign and malignant vascular tumors in patients.
PMID: 18413650 [PubMed - as supplied by publisher]
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Prevalence of hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion: 71 cases (2003-2005).
Fetched: April 17th, 2008, 9:00pm EDT
Related Articles Prevalence of hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion: 71 cases (2003-2005).
J Am Vet Med Assoc. 2008 Apr 15;232(8):1158
Authors:
PMID: 18412525 [PubMed - in process]
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Splenic angiosarcoma metastasis to the brain.
Fetched: April 16th, 2008, 9:00pm EDT
Related Articles Splenic angiosarcoma metastasis to the brain.
J Clin Neurosci. 2008 Apr 12;
Authors: Plotnik AN, Schweder P, Tsui A, Kavar B
Angiosarcoma is a rare primary non-haematolymphoid malignant neoplasm of the spleen. This neoplastic process has a poor prognosis, with disease usually widespread by the time of presentation. In the literature there has been only six case reports of cerebral metastasis from splenic angiosarcomas. We report a 61-year-old woman who presented with a right occipital metastasis of a splenic angiosarcoma, 5 years after initial diagnosis, treated by stereotactic occipital craniotomy and resection of metastasis.
PMID: 18411053 [PubMed - as supplied by publisher]
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[An autopsy case of chronic empyema-associated angiosarcoma that presented with a rapidly growing chest wall mass]
Fetched: April 16th, 2008, 9:00pm EDT
Related Articles [An autopsy case of chronic empyema-associated angiosarcoma that presented with a rapidly growing chest wall mass]
Nihon Kokyuki Gakkai Zasshi. 2008 Mar;46(3):248-52
Authors: Kusano N, Nishikawa M, Ito M, Kakemizu N
A 76-year-old woman with chronic tuberculous empyema presented with bloody sputa and anorexia in April 2005. Chest X-ray and CT scan showed no obvious change compared with previous films. She complained of a left chest pain in June 2005, and chest CT scan showed a tumor shadow enhanced heterogeneously on the left chest wall and chronic empyema. After admission, the chest wall mass grew rapidly. Neither CT- nor sonographically guided biopsy yielded a definitive diagnosis. Dynamic MRI showed a high signal intensity unlike hematoma. She died of respiratory failure 2 months after the onset of her chest pain. Autopsy revealed angiosarcoma. We should always keep in mind the early diagnosis of malignant tumor and tuberculosis in patients presenting with a chest wall mass and constitutional symptoms during follow-up of chronic tuberculous empyema.
PMID: 18409575 [PubMed - in process]
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Improved formulation of photosensitizer chlorin e6 polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer.
Fetched: April 9th, 2008, 9:00pm EDT
Related Articles Improved formulation of photosensitizer chlorin e6 polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer.
Eur J Pharm Biopharm. 2008 Mar 10;
Authors: Chin WW, Heng PW, Thong PS, Bhuvaneswari R, Hirt W, Kuenzel S, Soo KC, Olivo M
An improved formulation of the photosensitizer chlorin e6 (Ce6) in combination with the hydrophilic polymer polyvinylpyrrolidone (PVP) was investigated for its potential clinical applications in fluorescence diagnosis and photodynamic therapy (PDT) of cancer. This study reports the comparative preclinical biodistribution and efficacy of Ce6 delivered with or without PVP versus dimethyl sulfoxide (DMSO). The safety and fluorescence pharmacokinetics of Ce6-PVP in humans was also accessed. Biodistribution results showed that Ce6-PVP had higher tumor to normal tissue ratio compared to the other formulations. The sensitivity and specificity derived from the area under the receiver operating characteristics curves showed that the formulations were able to discriminate tumor from peritumoral muscle in the following order: Ce6-PVP>Ce6>Ce6-DMSO. In vitro PDT results showed that Ce6-PVP was found to induce selective phototoxicity in leukemic cells compared to peripheral mononuclear blood cells. In addition, in vivo light irradiation at 1h after Ce6-PVP was found to induce greater tumor necrosis without causing animal toxicity. In patients, preferential accumulation of Ce6-PVP was observed in angiosarcoma lesions compared to normal skin following intravenous administration. In conclusion, PVP significantly enhanced the Ce6 concentration in tumors compared with Ce6 alone and increased the therapeutic index of PDT without any side effects in animal model. No serious adverse events were observed in human as well.
PMID: 18396019 [PubMed - as supplied by publisher]
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Successful Treatment of Primary Cardiac Angiosarcoma With Docetaxel and Radiotherapy.
Fetched: April 5th, 2008, 9:00pm EDT
Related Articles Successful Treatment of Primary Cardiac Angiosarcoma With Docetaxel and Radiotherapy.
Angiology. 2008 Apr 2;
Authors: Nakamura-Horigome M, Koyama J, Eizawa T, Kasai H, Kumazaki S, Tsutsui H, Koiwai K, Oguchi K, Kinoshita O, Ikeda U
A 49-year-old man was admitted for primary cardiac angiosarcoma with a cardiac tamponade. Transthoracic echocardiography and contrast-enhanced computed tomography scan demonstrated a large mass in the right atrium and thickening of the right ventricular wall. (18)F-labeled deoxyglucose (FDG) positron emission tomography (PET) scan showed increased FDG uptake in the mediastinum and over the heart. The patient responded to combination therapy with docetaxel and radiotherapy and tolerated the treatment well, except for radiation esophagitis, which required a soft diet and resolved 1 month after treatment. This combination therapy resulted in a minimal response with slight regression in the tumor size, but FDG-PET initially showed an increase in FDG uptake by the tumor that was no longer seen after combination therapy. There is no evidence of progression or metastasis even at 12 months after diagnosis.
PMID: 18388090 [PubMed - as supplied by publisher]
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Aortic angiosarcoma mimicking large-vessel vasculitis: a diagnostic dilemma.
Fetched: April 4th, 2008, 9:00pm EDT
Related Articles Aortic angiosarcoma mimicking large-vessel vasculitis: a diagnostic dilemma.
Rheumatology (Oxford). 2008 Apr 2;
Authors: Abdin-Mohamed M, Ledingham J, Witham F, McCrae F
PMID: 18385216 [PubMed - as supplied by publisher]
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Angiosarcoma presenting as syncope.
Fetched: April 3rd, 2008, 9:00pm EDT
Related Articles Angiosarcoma presenting as syncope.
Asian Cardiovasc Thorac Ann. 2008 Apr;16(2):154-6
Authors: Nayar S, Nayar PG, Cherian K
A 31-year-old lady presented with anemia and syncope. Echocardiography revealed massive pericardial effusion with a right atrial mass. Transesophageal echocardiography, computed tomography and magnetic resonance imaging scans confirmed presence of a right atrial mass. Histopathology revealed a high grade angiosarcoma. Complete resection was done and the patient was referred to an oncology unit for further management. After three months the patient had extensive metastasis and succumbed to the disease. This case report highlights the clinical presentation, rapid and aggressive course of cardiac angiosarcomas.
PMID: 18381877 [PubMed - in process]
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Angiosarcoma of the Thoracoabdominal Aorta Presenting with Systemic Hypertension, Anemia, and Visceral Ischemia.
Fetched: March 28th, 2008, 9:00pm EDT
Related Articles Angiosarcoma of the Thoracoabdominal Aorta Presenting with Systemic Hypertension, Anemia, and Visceral Ischemia.
Ann Vasc Surg. 2008 Mar 24;
Authors: Karamlou T, Li MK, Williamson WK, Heller L, Wiest JW
Aortic angiosarcomas, one of the three major types of primary aortic tumors, are exceedingly rare, with only 25 cases reported in the literature. Peripheral thromboembolic complications are the most frequently described presenting feature, and therefore, these tumors can be mistaken for aortoiliac occlusive disease. We describe a rare case of an extensive thoracoabdominal angiosarcoma that manifested with hypertension, profound anemia, and visceral ischemia in a young woman.
PMID: 18367372 [PubMed - as supplied by publisher]
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Malignant transformation of testicular teratoma: A chemoresistant phenotype.
Fetched: March 28th, 2008, 9:00pm EDT
Related Articles Malignant transformation of testicular teratoma: A chemoresistant phenotype.
Urol Oncol. 2008 Jan 11;
Authors: Spiess PE, Pisters LL, Liu P, Pettaway CA, Kamat AM, Gomez JA, Tannir NM
PURPOSE: To review our experience in the management of malignant transformation of teratoma (MTT). MATERIALS AND METHODS: Nine patients with MTT were identified from January 1980 to August 2005, with all pathological specimens re-reviewed by a single genitourinary pathologist. RESULTS: Two patients presented with clinical stage I disease in which malignant transformation occurred within the primary testis tumor (rhabdomyosarcoma in 1 and adenocarcinoma in 1). These patients underwent a primary retroperitoneal lymph node dissection (RPLND). No viable tumor was identified in the specimen, and both patients were alive without disease at 16 months follow-up. Of the remaining 7 patients, the clinical stages were IIA (N = 1), IIB (N = 3), and III (N = 3), and all were treated with chemotherapy followed by RPLND. The MTT histology of these RPLND specimens consisted of adenocarcinoma (N = 3), rhabdomyosarcoma (N = 2), angiosarcoma (N = 1), and astrocytoma (N = 1). Following preoperative chemotherapy, a significant radiologic response (defined as more than a 25% reduction in maximum tumor circumferential diameter) was demonstrated in 1 patient, and normalization of serum tumor markers was demonstrated in 6. At a mean follow-up of 5 years, 3 of these 7 patients were alive with no evidence of disease, 1 had persistent disease, and 3 had died of disease, and their median disease-specific survival duration was 4.6 years. CONCLUSIONS: In our experience, MTT is significantly resistant to current chemotherapeutic regimens, as demonstrated by its poor radiologic response to treatment. Alternative therapeutic strategies targeted to MTT are thus needed.
PMID: 18367105 [PubMed - as supplied by publisher]
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Unresectable Chemorefractory Liver Metastases: Radioembolization with 90Y Microspheres--Safety, Efficacy, and Survival.
Fetched: March 20th, 2008, 9:00pm EDT
Related Articles Unresectable Chemorefractory Liver Metastases: Radioembolization with 90Y Microspheres--Safety, Efficacy, and Survival.
Radiology. 2008 Mar 18;
Authors: Sato KT, Lewandowski RJ, Mulcahy MF, Atassi B, Ryu RK, Gates VL, Nemcek AA, Barakat O, Benson A, Mandal R, Talamonti M, Wong CY, Miller FH, Newman SB, Shaw JM, Thurston KG, Omary RA, Salem R
Purpose: To prospectively evaluate the safety, efficacy, and survival of patients with chemorefractory liver metastases who have been treated with yttrium 90 ((90)Y) glass microspheres. Materials and Methods: Institutional review boards from two institutions approved the HIPAA-compliant study; all patients provided informed consent. One hundred thirty-seven patients underwent 225 administrations of (90)Y microspheres by using intraarterial infusion. Primary sites (origins) included colon, breast, neuroendocrine, pancreas, lung, cholangiocarcinoma, melanoma, renal, esophageal, ovary, adenocarcinoma of unknown primary, lymphoma, gastric, duodenal, bladder, angiosarcoma, squamous cell carcinoma, thyroid, adrenal, and parotid. Patients underwent evaluation of baseline and follow-up liver function and tumor markers and computed tomographic or magnetic resonance imaging. Patients were observed for survival from first treatment. Median survival (in days) and corresponding 95% confidence intervals were computed by using the Kaplan-Meier method. The log-rank statistic was used for statistical significance testing of survival distributions between various subgroups of patients. Results: There were 66 men and 71 women. All patients were treated on an outpatient basis. Median age was 61 years. The mean number of treatments was 1.6. The median activity and dose infused were 1.83 GBq and 112.8 Gy, respectively. Clinical toxicities included fatigue (56%), vague abdominal pain (26%), and nausea (23%). At follow-up imaging, according to World Health Organization criteria, there was a 42.8% response rate (2.1% complete response, 40.7% partial response). There was a biologic tumor response (any decrease in tumor size) of 87%. Overall median survival was 300 days. One-year survival was 47.8%, and 2-year survival was 30.9%. Median survival was 457 days for patients with colorectal tumors, 776 days for those with neuroendocrine tumors, and 207 days for those with noncolorectal, nonneuroendocrine tumors. Conclusion:(90)Y hepatic treatments are well tolerated with acceptable toxicities; tumor response and median survival are promising. Clinical trial registration no. NCT00532740 [www.cancer.gov] (c) RSNA, 2008.
PMID: 18349311 [PubMed - as supplied by publisher]
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Prognostic factors for adult sarcomas of head and neck.
Fetched: March 18th, 2008, 9:00pm EDT
Related Articles Prognostic factors for adult sarcomas of head and neck.
Int J Oral Maxillofac Surg. 2008 Mar 13;
Authors: Penel N, Mallet Y, Robin YM, Fournier C, Grosjean J, Ceugnart L, Clisant S, Lefebvre JL
The optimal management of adult soft-tissue sarcomas is not clearly established. To assess prognostic factors and survival, the experience of 45 recent successive cases was reviewed. Data were collected from a retrospective database (1993-2005) and statistically analyzed. Rhabdomyosarcomas were excluded. The mean age was 50.1 years; there were 24 men and 21 women. The main histological subtypes were undifferentiated sarcoma (14) and angiosarcoma (10); 21 tumours were grade 3 (46%). The most frequent primary sites were neck muscles (15, 33%) and scalp (11, 24%). At presentation, 5 (20%) cases with lymph-node involvement and another 11 cases (24%) with distant metastasis were observed. The treatment was with curative intent in 33 cases (73%). This entailed surgery, with adjuvant radiotherapy in 15 cases and adjuvant chemotherapy in 5 cases. The 5-year overall survival was 52% (+/-8%). In univariate analysis, the poor prognostic factors were high grade, initial metastasis or lymph nodes, absence of surgery, and number of surgical procedures. In multivariate analysis, two factors remained significant: grade (P=0.006) and absence of surgery (P=0.005). After taking into account grade and metastasis at presentation, quality of surgery has prognostic value. The primary aim of a multidisciplinary approach to these tumours must favour complete resection.
PMID: 18343096 [PubMed - as supplied by publisher]
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[Primary cutaneous and metastasing haemangiosarcoma in an addax (Addax nasomaculatus)]
Fetched: March 18th, 2008, 9:00pm EDT
Related Articles [Primary cutaneous and metastasing haemangiosarcoma in an addax (Addax nasomaculatus)]
Dtsch Tierarztl Wochenschr. 2008 Jan;115(1):20-5
Authors: Wohlsein P, Schöpper H, Kämmerling J, Wünsch U, Schulze C
Neoplastic diseases were described very rarely in addax (Addax nasomaculatus). In this communication clinical signs, morphological and immunohistological findings in a 15-year-old, female addax with a primary cutaneous, re-occurring and metastasing haemangiosarcoma of a forelimb are reported.
PMID: 18265754 [PubMed - indexed for MEDLINE]
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Intrathoracic malignant peripheral nerve sheath tumor with angiosarcoma in a child with NF1.
Fetched: March 15th, 2008, 9:00pm EDT
Related Articles Intrathoracic malignant peripheral nerve sheath tumor with angiosarcoma in a child with NF1.
Tumori. 2007 Nov-Dec;93(6):641-4
Authors: Elli M, Can B, Ceyhan M, Pinarli FG, Dagdemir A, Ayyildiz HS, Gürsel B, Dagçinar A
Malignant peripheral nerve sheath tumors (MPNSTs) are uncommon in children and adolescents but occur more frequently in NF1 patients. Angiosarcomatous differentiation in MPNSTs is a rare entity with poor prognosis. We report on a 13-year-old boy with intrathoracic angiosarcoma arising in MPNST associated with NF1.
PMID: 18338507 [PubMed - in process]
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Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report.
Fetched: March 15th, 2008, 9:00pm EDT
Related Articles Duodenal epithelioid angiosarcoma: immunohistochemical and clinical findings. A case report.
Tumori. 2007 Nov-Dec;93(6):619-21
Authors: Mignogna C, Simonetti S, Galloro G, Magno L, De Cecio R, Insabato L
Angiosarcomas are uncommon malignant tumors of vascular endothelium that represent less than 1% of all sarcomas. The epithelioid variant of angiosarcomas is exceptionally rare, and the gastrointestinal tract is rarely involved. Angiosarcomas mainly involve skin and soft tissue and rarely occur in breast, liver, bone, and spleen. We present the case of a 30-year-old man who underwent an upper gastrointestinal endoscopy for melena. A duodenal reddish polypoid lesion was found, which on microscopic examination turned out to be an epithelioid angiosarcoma. The immunohistochemical features of the lesion supported this diagnosis. The patient died eight months after the diagnosis. Epithelioid angiosarcoma is an aggressive variant of angiosarcoma and must be considered in the differential diagnosis of gastrointestinal tumors.
PMID: 18338501 [PubMed - in process]
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Liver transplantation for non-hepatocellular carcinoma malignancy.
Fetched: March 12th, 2008, 9:00pm EDT
Liver transplantation for non-hepatocellular carcinoma malignancy.
HPB (Oxford). 2007;9(2):98-103
Authors: Castaldo ET, Wright Pinson C
Liver transplantation (LT) for hepatocellular carcinoma is effective for selected patients. LT for other malignancies like cholangiocarcinoma (CCA), hepatoblastoma (HB), hepatic epithelioid hemangioepithelioma (HEHE), angiosarcoma (AS), and neuroendocrine tumors (NET) is being defined. For CCA, series that did not emphasize highly selected early stage disease and neoadjuvant or adjuvant chemoradiation had an average 5-year survival of 10%. However, emphasizing neoadjuvant radiation and chemosensitization in operatively confirmed stage I or II hilar CCA has led to improved 5-year survival, up to 82%. LT is indicated under strict research protocols at selected centers, for patients with early stage CCA and anatomically unresectable (Bismuth type IV) lesions. HB is typically sensitive to cisplatin-based chemotherapy. LT plays a role as primary surgical therapy for those individuals in whom tumors remain unresectable after chemotherapy or as rescue therapy for those who are incompletely resected, recur after resection, or develop hepatic insufficiency after chemotherapy and/or resection. Long-term survival is reported at 58-88%. HEHE is a multifocal tumor that lies somewhere between benign hemangiomas and malignant AS. The extensive multifocal nature makes resection difficult and LT an attractive option. Series on LT for HEHE report overall survival of 71-78% at 5 years. However, AS is an aggressive tumor and LT is contraindicated. For NET, resection of the primary tumor and all gross metastatic disease is reported to provide 5-year survival of 70-85%. LT has been employed for some patients for unresectable tumors or for palliation of medically uncontrollable symptoms with 5-year survival reported between 36% and 80%.
PMID: 18333123 [PubMed - in process]
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A Phase I Study of Docetaxel and Bexarotene.
Fetched: March 12th, 2008, 9:00pm EDT
A Phase I Study of Docetaxel and Bexarotene.
Chemotherapy. 2008 Mar 7;54(2):125-130
Authors: Wildi JD, Baggstrom MQ, Suresh R, Read W, Fracasso PM, Govindan R
Background: We conducted a single-arm, dose-escalation, phase 1 clinical trial in order to define the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of bexarotene in combination with docetaxel. Methods: Patients with solid tumors and no other curative treatment options were eligible. Oral bexarotene was taken daily in combination with docetaxel 25 mg/m(2) administered intravenously on days 1, 8, and 15 of a 28-day cycle. The dose of bexarotene started at 200 mg/m(2) and increased by 100 mg/m(2)/dose level, until either a MTD or the final dose of 400 mg/m(2) was reached. Results:Fifteen patients were enrolled in the study. Median age was 58 years. The majority had non-small-cell lung cancer. The study went to completion without reaching an MTD. Hematological toxicities were mild. Three patients developed grade 3 hypertriglyceridemia, all occurring during the first cycle of treatment. No objective responses were noted. Four patients had stable disease as a best response, 3 with non-small-cell lung cancer and 1 with angiosarcoma. Conclusions:Treatment was well tolerated and no DLT was seen at docetaxel 25 mg/m(2) and bexarotene 400 mg/m(2). Given that stable disease was durable in 4 patients, future studies with this combination may be warranted. Copyright (c) 2008 S. Karger AG, Basel.
PMID: 18332628 [PubMed - as supplied by publisher]
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Fine needle aspiration cytology of epithelioid angiosarcoma: a case report.
Fetched: March 8th, 2008, 9:00pm EST
Related Articles Fine needle aspiration cytology of epithelioid angiosarcoma: a case report.
Acta Cytol. 2008 Jan-Feb;52(1):109-13
Authors: Siddaraju N, Soundararaghavan J, Bundele MM, Roy SK
BACKGROUND: Malignant vascular tumors are rare. Few studies have described cytomorphologic features of hemangioendothelioma and angiosarcoma on fine needle aspiration cytology (FNAC). Malignant vascular tumor with epithelioid morphology can create diagnostic difficulty, as the cytology may simulate that in other nonvascular malignant tumors. We describe epithelioid angiosarcoma, diagnosed on FNAC, in which a differential diagnosis of histiocytosis and inflammatory granulation tissue was considered. CASE: A 20-year-old man presented with forehead and scalp swellings. The forehead lesion was radiologiocally associated with a lytic lesion in the bone. FNA resulted in high cellular yield, and smears revealed prominent vascular pattern with endothelial cell atypia and histiocytoid/epithelioid neoplastic cells, occasional mitotic figures and a few cells displaying nuclear grooving. Smear background showed a significant number of neutrophils. Epithelioid hemangioendothelioma/angiosarcoma, histiocytosis and inflammatory granulation tissue were considered. A cytologic diagnosis of epithelioid angiosarcoma/epithelioid hemangioendothelioma was suggested and confirmed on histopathologic and immunohistochemical examination. CONCLUSION: Cellular aspirates from malignant epithelioid endothelial tumors involving bone may be cytologically mistaken for histiocytosis and, rarely, inflammatory granulation tissue. However, prominent vascular pattern with striking endothelial cell atypia, presence of mitotic figures and careful search for presence of endothelial differentiation are helpful in accurate cytologic diagnosis.
PMID: 18323286 [PubMed - in process]
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Primary cardiac angiosarcoma with right coronary-toright atrium fistula.
Fetched: March 6th, 2008, 9:00pm EST
Related Articles Primary cardiac angiosarcoma with right coronary-toright atrium fistula.
Cardiovasc J Afr. 2008 Jan-Feb;19(1):26-7
Authors: Yildiz A, Yakut N, Kurtoglu T, Okcun B, Kupelioglu A
Primary tumours of the heart are rare. About 25% of all cardiac tumours are malignant and the most common of these is the angiosarcoma. We present a 61-year-old male with a right atrial angiosarcoma that was detected on coronary angiography. The tumour showed marked vascularity and a right coronary-to-right atrium fistula, and the patient underwent surgical resection. Pathological examination of the tumour was consistent with a cardiac angiosacoma and the diagnosis was also confirmed by immuno-histochemistry. He consequently underwent chemotherapy, however the patient died 60 days after the surgery.
PMID: 18320083 [PubMed - in process]
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C-reactive protein concentration in dogs with various diseases.
Fetched: March 6th, 2008, 9:00pm EST
Related Articles C-reactive protein concentration in dogs with various diseases.
J Vet Med Sci. 2008 Feb;70(2):127-31
Authors: Nakamura M, Takahashi M, Ohno K, Koshino A, Nakashima K, Setoguchi A, Fujino Y, Tsujimoto H
To investigate the clinical utility of C-reactive protein (CRP) determination in dogs, its plasma concentration was measured by a laser nephelometric method in 928 dogs with various diseases, and was compared with other inflammatory parameters. CRP concentration was elevated in various inflammatory diseases, this was most frequently observed in cases with neoplastic and immune-mediated diseases. All cases of pyometra, panniculitis, acute pancreatitis, polyarthritis, and hemangiosarcoma showed significantly elevated CRP concentrations. On the other hand, the CRP concentration was elevated only in few cases of neurological diseases such as epilepsy, meningoencephalitis, and hydrocephalus and endocrine diseases such as hypothyroidism, hyperadrenocorticism, and diabetes mellitus. Only a weak correlation was observed between the CRP concentration and white blood cell (WBC) counts (r=0.44) but no correlation with band neutrophil counts. There was no correlation between the CRP and albumin concentrations, but a weak negative correlation (r=-0.40) when excluding chronic intestinal diseases and nephrotic syndrome, which can cause protein loss. Thus, CRP can be useful to detect inflammations that cannot be detected by WBC and, or band neutrophil counts, suggesting that the examination of CRP concentration is essential as routine diagnostic test.
PMID: 18319571 [PubMed - in process]
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[Clinical and pathological analysis of 10 cases of secondary pneumothorax due to angiosarcoma of the scalp]
Fetched: March 6th, 2008, 9:00pm EST
Related Articles [Clinical and pathological analysis of 10 cases of secondary pneumothorax due to angiosarcoma of the scalp]
Nihon Kokyuki Gakkai Zasshi. 2008 Feb;46(2):85-91
Authors: Goto H, Watanuki Y, Miyazawa N, Kudo M, Inoue S, Kobayashi N, Kaneko T, Ishigatsubo Y
Angiosarcoma of the scalp is a very rare disease. Secondary pneumothorax is known as a characteristic complication in this disease due to lung metastasis. In this study, 17 patients of angiosarcoma of the scalp, diagnosed at our hospital between 1996 and 2006, were analyzed. Secondary pneumothorax was observed in 10 of these patients, among which bilateral pneumothorax occurred in 5 relapse of pneumothorax occurred in 6 and pneumothorax with bloody pleural fluid occurred in 7 patients. Characteristic findings on chest CT were multiple thin-wall cavities and ground-glass attenuation around the cavity, located in bilateral subpleural lung fields. It is suggested that the subpleural thin-wall cavities cause pneumothorax. Although pleurosclerosis were performed in 5 patients and one of them had a subsequent partial resection of the lung, pneumothorax reocurred within a short period of time in all patients. The average survival time from the first pneumothorax episode was only 4.1 months. Secondary pneumothorax caused by this disease was intractable, resulting in an unfavorable outcome. It is necessary to develop a proper treatment strategy for secondary pneumothorax to create a favorable prognosis in this disease.
PMID: 18318248 [PubMed - in process]
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Adenoid Squamous Carcinoma (Pseudoangiosarcomatous Carcinoma) of the Vulva: A Rare but Highly Aggressive Variant of Squamous Cell Carcinoma-Report of a Case and Review of the Literature.
Fetched: March 5th, 2008, 9:00pm EST
Related Articles Adenoid Squamous Carcinoma (Pseudoangiosarcomatous Carcinoma) of the Vulva: A Rare but Highly Aggressive Variant of Squamous Cell Carcinoma-Report of a Case and Review of the Literature.
Int J Gynecol Pathol. 2008 Feb 27;
Authors: Horn LC, Liebert UG, Edelmann J, Höckel M, Einenkel J
SUMMARY: Pseudoangiosarcomatous squamous cell carcinoma is an unusual but aggressive variant of acantholytic squamous cell carcinoma of the vulva that mimics angiosarcoma on histology. We present a case of a 57-year-old woman with bilateral inguinal metastatic disease at the time of diagnosis, who died 4 months later because of distant metastatic disease to the lungs. Molecular analysis did not reveal any human papillomavirus infection. Because of the positive p53 immunostaining and the association to lichen sclerosus and simple type of high-grade vulvar intraepithelial neoplasia, alteration of p53 tumor suppressor gene might be involved in the pathogenesis of vulvar pseudoangiosarcomatous squamous cell carcinoma. However, further molecular studies are required.
PMID: 18317210 [PubMed - as supplied by publisher]
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CD99 - much ado about nothing?
Fetched: March 5th, 2008, 9:00pm EST
Related Articles CD99 - much ado about nothing?
J Cutan Pathol. 2008 Jan;35(1):86-7
Authors: Pozdnyakova O, Mahalingam M
PMID: 18096002 [PubMed - indexed for MEDLINE]