Long-term local control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and postoperative radiation.
Laryngoscope. 2017 Mar 21;:
Authors: Ali S, Palmer FL, Katabi N, Lee N, Shah JP, Patel SG, Ganly I
OBJECTIVES: To report long-term local control in patients with adenoid cystic cancer (ACC) of the head and neck managed by surgery and identify factors predictive for local failure.
STUDY DESIGN: Single-institution retrospective cohort study.
METHODS: Eighty-seven patients who had surgery for ACC between 1985 and 2009 were identified. Patient, tumor, and treatment characteristics were recorded. Local recurrence-free survival (LRFS) was recorded by the Kaplan-Meier method. Predictors of local control were identified.
RESULTS: The median age was 54 years. Seventy-two (83%) patients had perineural invasion, 61 (70%) had close/positive margins, and 58 (67%) had pT 1T2. Fifty-nine (68%) patients had postoperative radiation therapy (PORT). With a median follow-up of 85 months, the 10-year LRFS was 78.7%. There were 14 local recurrences. On multivariable analysis, pathological tumor (T)3T4 stage and no PORT were independent predictors for local failure. Patients with no PORT had a 13-fold increased risk of local failure compared to patients treated with PORT (P = 0.003) after adjusting for stage.
CONCLUSION: After adjusting for T stage, patients who do not get PORT are more likely to have local recurrence.
LEVEL OF EVIDENCE: 4. Laryngoscope, 2017.
PMID: 28322454 [PubMed - as supplied by publisher]