 Process & Control Today | Process & Control Today ... a long duration leading to the development of a number of life-threatening diseases, including liver cancer, brain cancer, lung cancer and angiosarcoma. ... |
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Google - Angiosarcoma
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Poison Plastics – Do you know what's under the lid? - Process & Control Today
Posted: July 27th, 2010, 11:51pm CDT
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What is health? Money. - Daily Kos (blog)
Posted: July 25th, 2010, 1:15pm CDT
What is health? Money.
Daily Kos (blog)
Here's a link to what they will do (don't open if you are...faint of heart at the site of blood and surgery): Cardiac angiosarcoma resection Blood and gore? ... -
Molokai 2 Oahu Race - The girls - Hawaii News Now
Posted: July 22nd, 2010, 7:49pm CDT
Molokai 2 Oahu Race - The girls
Hawaii News Now
Scott's cousin, Dodge Ackerman had two rare sarcoma cancers, angiosarcoma and rhabdomyosarcoma that cut short his life. Sarcomas occur in connective tissue, ...
and more » -
Sweetest Relief - The Portland Mercury
Posted: July 21st, 2010, 5:19pm CDT
The Portland MercurySweetest Relief
The Portland Mercury
... music scene and a former Kill Rock Stars employee who has been recently diagnosed with a particularly brutal form of cancer known as angiosarcoma. ... -
So...What DID Happen to Vanessa Juarez? - WBAN
Posted: July 17th, 2010, 6:50pm CDT
WBANSo...What DID Happen to Vanessa Juarez?
WBAN
Sure enough my cancer Angiosarcoma, a rare type of cancer had returned." "When I started fighting cancer, Vanessa stopped boxing to help me get through my ... -
Riot grrrls revisited - The Olympian
Posted: July 16th, 2010, 9:40am CDT
Riot grrrls revisited
The Olympian
... women are coming together again to support Natalie Cox, one of the original riot grrrls, who is living with an aggressive cancer called angiosarcoma. ... -
Heal rock stars - Weekly Volcano
Posted: July 14th, 2010, 6:20pm CDT
Heal rock stars
Weekly Volcano
s altruism is former Kill Rock Stars employee Natalie Cox, a prominent figure in the Oly music scene who was diagnosed with angiosarcoma in July of last ... -
Rocket Queen: The Needs of a Friend - Seattle Weekly
Posted: July 14th, 2010, 8:32am CDT
Rocket Queen: The Needs of a Friend
Seattle Weekly
"While angiosarcoma is a very different beast than breast cancer, we were on parallel paths: We both cut off our tits, went to hell and back, ... -
Campaign Underway to Declare July as Sarcoma Awareness Month - PR Web (press release)
Posted: July 5th, 2010, 7:08am CDT
Campaign Underway to Declare July as Sarcoma Awareness Month
PR Web (press release)
... Fla., is on the board of the Sarcoma Foundation of America in Damascus, Md. He has been in remission from angiosarcoma for five years. ...
and more » -
DINE OUT FOR COPS IN NEED TODAY! - Sunday Paper (blog)
Posted: June 29th, 2010, 11:35am CDT
DINE OUT FOR COPS IN NEED TODAY!
Sunday Paper (blog)
... a former Atlanta Police Department narcotics officer who has angiosarcoma; Detective Styron Traylor a young officer who suffered a stroke last August; ... -
SOME GOOD COPS NEED YOUR HELP - Sunday Paper (blog)
Posted: June 23rd, 2010, 8:10pm CDT
SOME GOOD COPS NEED YOUR HELP
Sunday Paper (blog)
... a former Atlanta Police Department narcotics officer who has angiosarcoma; Detective Styron Traylor a young officer who suffered a stroke last August; ...
PubMed - Angiosarcoma
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Angiosarcoma arising within a Malignant Endovascular Papillary Angioendothelioma (Dabska tumor).
Fetched: September 1st, 2010, 9:30am CDT
Related Articles Angiosarcoma arising within a Malignant Endovascular Papillary Angioendothelioma (Dabska tumor).
Neuro Endocrinol Lett. 2010 Aug 30;31(4)
Authors: Antosz Z, Zaniewski M, Kostecki J
We report an angiosarcoma arising within a malignant endovascular papillary angioendothelioma (Dabska tumor) in soft tissue of the upper thigh/buttock of a 42-year-old woman. Although neoplastic progression within a vascular tumor of an existing low-grade lesion into DT has been described so far, we seem to be the first to report transformation of DT into an angiosarcoma.
PMID: 20802459 [PubMed - as supplied by publisher]
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Hemorrhagic Tamponade Due to Cardiac Angiosarcoma.
Fetched: September 1st, 2010, 9:30am CDT
Related Articles Hemorrhagic Tamponade Due to Cardiac Angiosarcoma.
South Med J. 2010 Aug 26;
Authors: Vautrin E, Barone-Rochette G, Thony F, Lantuejoul S, Towie DH, Bach V, Baguet JP
Prognosis of angiosarcoma, the most common primary malignant cardiac tumor, is very poor. An early detection and treatment may extend survival beyond one year. Newer imaging modalities, including magnetic resonance imaging (MRI), play an important role in the evaluation of cardiac masses. The case of a man admitted to the emergency room for a cardiac tamponade is reported. Thoracic computed tomography and MRI diagnosed a pericardial tumor, for which surgical biopsy revealed an angiosarcoma. Chemotherapy was started, and the patient survived for 28 months. Etiologies of hemorrhagic tamponades are discussed, as well as treatment of cardiac angiosarcoma.
PMID: 20802380 [PubMed - as supplied by publisher]
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Development and Application of an LC-MS/MS Method for the Detection of the Vinyl Chloride-Induced DNA Adduct N(2),3-Ethenoguanine in Tissues of Adult and Weanling Rats Following Exposure to [(13)C(2)]-VC.
Fetched: September 1st, 2010, 9:30am CDT
Related Articles Development and Application of an LC-MS/MS Method for the Detection of the Vinyl Chloride-Induced DNA Adduct N(2),3-Ethenoguanine in Tissues of Adult and Weanling Rats Following Exposure to [(13)C(2)]-VC.
Chem Res Toxicol. 2010 Aug 30;
Authors: Mutlu E, Collins LB, Stout MD, Upton PB, Daye LR, Winsett D, Hatch G, Evansky P, Swenberg JA
In the 1970s, exposure to vinyl chloride (VC) was shown to cause liver angiosarcoma in VC workers. We have developed a new LC-MS/MS method for analyzing the promutagenic DNA adduct N(2),3-ethenoguanine (epsilonG) and have applied this to DNA from tissues of both adult and weanling rats exposed to 1100 ppm [(13)C(2)]-VC for 5 days or 1100 ppm VC for 1 day. This assay utilizes neutral thermal hydrolysis and an HPLC cleanup prior to quantitation by LC-MS/MS. The number of endogenous and exogenous epsilonG adducts in DNA from tissues of adult rats exposed to [(13)C(2)]-VC for 5 days was 4.1 +/- 2.8 adducts/10(8) guanine of endogenous and 19.0 +/- 4.9 adducts/10(8) guanine of exogenous epsilonG in the liver, 8.4 +/- 2.8 adducts/10(8) guanine of endogenous and 7.4 +/- 0.5 adducts/10(8) guanine of exogenous epsilonG in the lung, and 5.9 +/- 3.3 adducts/10(8) guanine of endogenous and 5.7 +/- 2.1 adducts/10(8) guanine of exogenous epsilonG in the kidney (n = 4). Additionally, the data from weanling rats demonstrated higher numbers of exogenous epsilonG, with approximately 4-fold higher amounts in the liver DNA of weanlings (75.9 +/- 17.9 adducts/10(8) guanine) in comparison to adult rats and approximately 2-fold higher amounts in the lung (15.8 +/- 3.6 adducts/10(8) guanine) and kidney (12.9 +/- 0.4 adducts/10(8) guanine) (n = 8). The use of stable isotope labeled VC permitted accurate estimates of the half-life of epsilonG for the first time by comparing [(13)C(2)]-epsilonG in adult rats with identically exposed animals euthanized 2, 4, or 8 weeks later. The half-life of epsilonG was found to be 150 days in the liver and lung and 75 days in the kidney, suggesting little or no active repair of this promutagenic adduct.
PMID: 20799743 [PubMed - as supplied by publisher]
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Epithelioid Angiosarcoma in a Patient with Klippel-Trénaunay-Weber Syndrome: An Unexpected Response to Therapy.
Fetched: September 1st, 2010, 9:30am CDT
Related Articles Epithelioid Angiosarcoma in a Patient with Klippel-Trénaunay-Weber Syndrome: An Unexpected Response to Therapy.
Case Rep Oncol. 2010;3(2):148-153
Authors: Simas A, Matos C, Lopes da Silva R, Brotas V, Teófilo E, Albino JP
We present a rare case of Stewart-Treves syndrome characterized by a diffuse angiosarcoma of the leg in a 22-year-old man with a history of chronic lymphedema due to Klippel-Trénaunay-Weber syndrome. He underwent limb disarticulation and medical treatment with cycles of doxorubicin, oral thalidomide and sunitinib with a very good response after 12 months of follow-up.
PMID: 20740188 [PubMed - as supplied by publisher]
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Primary Cardiac Angiosarcoma in a Young Woman.
Fetched: September 1st, 2010, 9:30am CDT
Related Articles Primary Cardiac Angiosarcoma in a Young Woman.
Case Rep Oncol. 2010;3(1):24-29
Authors: Pezzuto A, Gencarelli G, Martone L, Bruno P, Mariotta S
A 30-year-old woman was admitted to our hospital with severe shortness of breath. A transthoracic echocardiogram showed moderate pericardial effusion with a lesion in the right atrium, confirmed by chest CT scan and cardiac RMN. Pleural and middle lobe involvement occurred within one month. Middle lobe biopsy was performed and pathological examination confirmed the diagnosis of metastatic angiosarcoma. After two months, because of recurrent pleural effusions, chemical pleurodesis was performed. Chemotherapy was started but the patient died four months after the diagnosis. This case highlights the misdiagnosis at initial clinical presentation, available diagnostic approaches and therapeutic options for cardiac angiosarcoma.
PMID: 20740154 [PubMed - as supplied by publisher]
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Large Mass in Left Atrium by Transesophageal Echocardiography: An Unusual Case of Cardiac Angiosarcoma Mimicking a Cystic Mass.
Fetched: September 1st, 2010, 9:30am CDT
Related Articles Large Mass in Left Atrium by Transesophageal Echocardiography: An Unusual Case of Cardiac Angiosarcoma Mimicking a Cystic Mass.
Echocardiography. 2010 Aug 24;
Authors: Toledano FJ, Mesa D, Ortiz MR, Leon C
Primary cardiac tumors are extremely rare. Among them, malignant tumors constitute approximately 15% of primary cardiac tumors. Angiosarcomas are the most frequent. They often appear as mural masses in the right atrium and completely replace the atrial wall and fill the entire cardiac chamber. We report an unusual case of angiosarcoma in a 75-year-old woman with a cystic appearance, located in the left atrium and causing critical mitral stenosis. (Echocardiography, ****;**:E1-E2).
PMID: 20738371 [PubMed - as supplied by publisher]
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Complete long-term response of angiosarcoma of the scalp with cervical lymph node metastases treated with a combination of weekly and monthly docetaxel.
Fetched: September 1st, 2010, 9:30am CDT
Related Articles Complete long-term response of angiosarcoma of the scalp with cervical lymph node metastases treated with a combination of weekly and monthly docetaxel.
Br J Dermatol. 2010 Aug 20;
Authors: Nakamura Y, Nakamura Y, Hori E, Furuta J, Kawachi Y, Otsuka F
PMID: 20731655 [PubMed - as supplied by publisher]
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[Postirradiation angiosarcoma of the breast.]
Fetched: September 1st, 2010, 9:30am CDT
Related Articles [Postirradiation angiosarcoma of the breast.]
Magy Seb. 2010 Aug;63(4):164-7
Authors: Vertse G, Svastics E, Iványi A
Although secondary angiosarcomas (AS) are relatively rare neoplasms, they are increasingly recognized as the result of more breast conserving therapy (BCT) followed by radiotherapy. The diagnosis of this very aggressive and rapidly spreading tumour is based on the immunohystochemical characteristics of the biopsy specimen. Only radical surgical intervention can provide successful treatment. Authors present a case of a 56-y-old woman who underwent BCT and radiotherapy. 10 years later secondary AS occurred in the remaining breast.
PMID: 20724241 [PubMed - in process]
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Laparoscopic Splenectomy for Treatment of Splenic Hemangiosarcoma in a Dog.
Fetched: September 1st, 2010, 9:30am CDT
Related Articles Laparoscopic Splenectomy for Treatment of Splenic Hemangiosarcoma in a Dog.
Vet Surg. 2010 Aug 12;
Authors: Collard F, Nadeau ME, Carmel EN
Objective: To report laparoscopic splenectomy in a dog. Study Design: Clinical report. Animals: Mixed breed dog (n=1). Methods: Hemangiosarcoma was diagnosed by ultrasound-guided fine-needle aspiration of a splenic mass in an 11-year-old, 30 kg, mixed breed dog. No metastatic disease was identified during complete staging (chest radiographs, echocardiogram, and abdominal ultrasonography); however, cystic calculi were identified. Laparoscopic splenectomy using Ligasure V was performed through 3 portals and the calculi were removed by laparoscopic-assisted cystoscopy. Results: Total surgical time was 2 hours and for laparoscopic splenectomy, 65 minutes. The celiotomy incision for splenic removal was 7 cm. The dog recovered uneventfully and was ambulatory 2 hours postoperatively. Conclusion: Laparoscopy with Ligasure V facilitated successful removal of a spleen with a 3 cm mass. Clinical Relevance: Laparoscopic splenectomy in dogs is feasible for removal of a normal-sized spleen with a moderate-sized mass.
PMID: 20723196 [PubMed - as supplied by publisher]
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Angiosarcoma of the breast.
Fetched: September 1st, 2010, 9:30am CDT
Related Articles Angiosarcoma of the breast.
QJM. 2010 Aug 18;
Authors: Loo SW, Harnett AN
PMID: 20719901 [PubMed - as supplied by publisher]
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Primary and secondary neoplasms of the spleen.
Fetched: September 1st, 2010, 9:30am CDT
Related Articles Primary and secondary neoplasms of the spleen.
Cancer Imaging. 2010;10:173-82
Authors: Kaza RK, Azar S, Al-Hawary MM, Francis IR
With the exception of lymphoma involving the spleen, other primary and secondary neoplasms are rare and infrequently encountered. Primary malignant neoplasms involving the spleen are lymphoma and angiosarcoma. Primary benign neoplasms involving the spleen include hemangioma, lymphangioma, littoral cell angioma and splenic cyst and solid lesions such as hamartoma and inflammatory pseudotumor.
PMID: 20713317 [PubMed - in process]
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What is your diagnosis? Hemorrhagic effusion in a dog.
Fetched: September 1st, 2010, 9:30am CDT
Related Articles What is your diagnosis? Hemorrhagic effusion in a dog.
Vet Clin Pathol. 2009 Dec;38(4):529-31
Authors: Barger A, Riensche M
A 2-year-old spayed female, German Shepherd dog was presented to the University of Illinois Veterinary Teaching Hospital with a history of intermittent lethargy. On physical examination, lung sounds were increased. The dog had a mild fever (103.7 degrees F) and mild tachycardia (120 bpm). Thoracic ultrasound revealed a sternal mass and pericardial effusion, both of which were aspirated. On cytologic examination, the pericardial fluid contained a large amount of blood and was interpreted as a hemorrhagic effusion. Nucleated cells consisted mainly of macrophages containing phagocytized RBCs and hemosiderin and many clusters of reactive mesothelial cells. The majority of mesothelial cells contained variable amounts of rod-shaped brown pigment granules that were suspected to be iron. The granules were positive for Prussian blue and carbol-fuschin, indicative of iron potentially mixed with lipofuscin. The granules stained negatively with Melan A, rhodamine, Hall's, and periodic acid-Schiff. The iron within the mesothelial cells was likely secondary to hemorrhage, based on the erythrophagia and accumulation of hemosiderin in macrophages. Iron deposition and phagocytic activity in mesothelial cells has been reported previously in humans and rats, but not in dogs.
PMID: 19392765 [PubMed - indexed for MEDLINE]
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A case report of breast angiosarcoma.
Fetched: August 17th, 2010, 9:13am CDT
Related Articles A case report of breast angiosarcoma.
Coll Antropol. 2010 Jun;34(2):645-8
Authors: Kardum-Skelin I, JeliÄ-PuskariÄ B, Pazur M, VidiÄ-PaulisiÄ I, JakiÄ-RazumoviÄ J, SeparoviÄ V
Angiosarcoma is a rare disease of the breast with the reported incidence of only 0.04% of all breast malignancies. The etiology of angiosarcoma remains unknown. It occurs post-mastectomy, in association with chronic lymphedema (Stewart-Treves syndrome), or after radiotherapy. We present a patient with angiosarcoma which developed 12 years of the diagnosis of breast carcinoma and 8 years of the operative procedure and radiotherapy for disease recurrence. A small angiomatous lesion of a few mm in size, cytologically suspect of vascular tumor (hemangioma or hemangiopericytoma) and histopathologically verified to be an atypical vascular lesion, was detected two years before breast enlargement and cytologic and histologic diagnosis of angiosarcoma. The patient died 15 months of the diagnosis of angiosarcoma, after two tumor recurrences and intrathoracic cavity invasion.
PMID: 20698145 [PubMed - in process]
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Reconstructive Outcomes in Patients with Sarcoma of the Breast.
Fetched: August 17th, 2010, 9:13am CDT
Related Articles Reconstructive Outcomes in Patients with Sarcoma of the Breast.
Plast Reconstr Surg. 2010 Aug 5;
Authors: Crosby MA, Chike-Obi CJ, Baumann DP, Sacks JM, Villa MT, Garvey PB, Selber JC, Feig BW
BACKGROUND: Primary soft-tissue sarcomas account for less than 1 percent of all breast malignancies. Many of these are associated with prior radiation therapy. Few studies have evaluated this patient population. The purpose of this study was to examine reconstruction techniques and outcomes in a cohort of patients with breast sarcoma to elucidate the optimal type and timing of reconstruction. METHODS: We conducted a retrospective review of all patients diagnosed and treated for soft-tissue breast sarcomas between July 1, 1988, and December 9, 2009, at a tertiary cancer center. Data collected included demographics, histology, oncologic and reconstructive treatment, and clinical outcomes. RESULTS: Twenty-three breast sarcoma patients underwent twenty-four reconstructions. The mean age at diagnosis was 42 years (range 17-78). The most common histology was angiosarcoma; 6 of the 11 angiosarcomas developed following radiation for either breast carcinoma or lymphoma. The median follow-up time was 44 months. Twenty patients were alive through the follow-up period. Reconstruction was immediate in 20 cases and delayed in 4. The reconstruction used autologous tissue in 16 cases, implants in 5, and both in 3. All patients who received radiation during treatment underwent autologous-tissue reconstruction. Surgical complications included implant displacement, tissue expander displacement, total flap loss, seroma, implant exposure, and partial skin graft loss. CONCLUSIONS:: Soft-tissue breast sarcomas are uncommon and demand aggressive, multimodal treatment and well-planned reconstruction. Most sarcoma patients receive radiotherapy; to minimize complications, we recommend delayed autologous reconstruction after completion of radiotherapy.
PMID: 20697311 [PubMed - as supplied by publisher]
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Epithelioid Angiosarcoma of the Skin: A Study of 18 Cases With Emphasis on its Clinicopathologic Spectrum and Unusual Morphologic Features.
Fetched: August 17th, 2010, 9:13am CDT
Related Articles Epithelioid Angiosarcoma of the Skin: A Study of 18 Cases With Emphasis on its Clinicopathologic Spectrum and Unusual Morphologic Features.
Am J Surg Pathol. 2010 Aug 6;
Authors: Bacchi CE, Silva TR, Zambrano E, Plaza J, Suster S, Luzar B, Lamovec J, Pizzolitto S, Falconieri G
We report 18 cases of cutaneous angiosarcoma with predominant or exclusive epithelioid morphology. Both sexes were similarly affected. Patients' ages ranged from 2 to 97 years, median 77.5 years; 2 were pediatric patients. In elderly patients scalp or facial lesions and cutaneous lesions arising within irradiated breast skin predominated. Limb lesions were seen in younger patients. Microscopically, the tumors were composed of packed polygonal cells with focal evidence of endothelial differentiation. Diverging phenotypes included syncytial growth of large cells with clear nuclei and prominent nucleoli, micronodules of tumor cells scattered in dermis, predominance of discohesive plasmacytoid polygonal cells with abundant bright eosinophilic cytoplasm, sheets of clear cells with coarse granular cytoplasm, trabecular and cord arrangement of tumor cells splaying the dermal collagen, or a pseudoglandular appearance owing to clear cell tubular arrangement with open lumina. These cases posed further diagnostic challenges simulating lymphoma, melanoma, lymphoepithelioma-like carcinoma, adnexal carcinoma, and neuroendocrine carcinoma. Immunohistochemical studies showed positivity for CD31 and CD34; no immunoreactivity was documented for other tested antigens including cytokeratins, S100 protein, melanocytic antigens, leukocyte common antigen, and desmin. Therapeutic modalities included combined local excision, chemotherapy, and radiotherapy, depending on patient clinical status. Of the 9 patients available for follow-up, 5 were alive and apparently well, 2 had recurrent disease, and 2 had died of tumor. Our data show that epithelioid cutaneous angiosarcoma may have a broad morphological spectrum, raising interpretive challenges on microscopy. In addition, its clinical presentation seems to differ in nonelderly patients, with lesions likely related to lymphedema or vascular malformations.
PMID: 20697249 [PubMed - as supplied by publisher]
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Masson's Vegetant Hemangioendothelioma Arising in the Uterine Cervix During Pregnancy: A Case Report.
Fetched: August 17th, 2010, 9:13am CDT
Related Articles Masson's Vegetant Hemangioendothelioma Arising in the Uterine Cervix During Pregnancy: A Case Report.
J Womens Health (Larchmt). 2010 Aug 9;
Authors: Susini T, Molino C, Castiglione F, Olivieri S
Abstract Background: Hemangioendothelioma is a rare benign intravascular tumor that can be confused with other vascular neoplasms. We report the first case of cervical vegetant intravascular hemangioendothelioma (Masson's tumor) arising in a pregnant woman. Case report: A 40-year-old woman at 15 weeks' gestation developed a voluminous cervical mass and vaginal bleeding. We excised the lesion during pregnancy because of its rapid growth, bleeding, and severe pain. The pathological diagnosis was Masson's tumor or intravascular papillary endothelial hyperplasia. The tumor showed strong estrogen and progesterone receptor expression.The patient underwent an elective cesarean section at term, giving birth to a healthy baby. Clinical follow-up at 3 years showed no complications or recurrence. Conclusions: Obstetricians should be aware that Masson's tumor may occasionally arise in the uterine cervix during pregnancy. This benign vascular tumor may display a rapid growth because of the presence of sex steroid receptors. Differential diagnosis should consider a malignant vascular tumor, including Kaposi's sarcoma and angiosarcoma. Surgical removal should not be postponed because of pain and bleeding. Fetal and maternal outcomes were favorable.
PMID: 20695814 [PubMed - as supplied by publisher]
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[Surgical treatment of proximal femoral malignant tumors]
Fetched: August 17th, 2010, 9:13am CDT
Related Articles [Surgical treatment of proximal femoral malignant tumors]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010 Jul;24(7):881-4
Authors: Wang J, Yin J, Zou C, Xie X, Huang G, Li H, Shen J, Han S
OBJECTIVE: To evaluate the clinical outcomes of the wide resection and the functional reconstruction for treating malignant tumors of the proximal femur. METHODS: The clinical data were analysed from 62 patients with malignant tumors of the proximal femur treated between January 1987 and December 2007. There were 29 males and 33 females with a median age of 35 years (range, 14-73 years). In 41 patients with primary malignant tumors having a disease course of 0.5-14.0 months, there were 16 cases of osteosarcoma, 7 cases of fibrosaroma, 6 cases of chondrosarcoma, 6 cases of malignant fibrous histiocytoma, 4 cases of mesenchymal sarcoma,1 case of Ewing sarcoma, and 1 case of angiosarcoma, including 3 cases of type IB, 2 cases of type IIA, 35 cases of type IIB, and 1 case of type III according to Enneking stage. In 21 patients with metastatic tumors, 16 had a malignant tumor history; the disease course was 0.1-28.0 months (3.4 months on average). Radical resection was performed in 9 cases, extensive resection in 39 cases, and marginal resection in 14 cases. After resection, 39 cases underwent reconstruction with prostheses (prostheses group) and 14 cases underwent reconstruction with allograft-prosthetic composites (APC, APC group). RESULTS: All incision healed by first intention. Twenty-six cases died of tumor metastasis, their postoperative survive time was 16-56 months (28 months on average). The average follow-up time was 64 months (range, 28-221 months) in 36 survival patients. The local recurrence rate of primary malignant tumors was 4.88% (2/41). In prostheses group, dislocation of femoral head occurred in 2 cases, fracture of prosthetic stem in 1 case, hip pain in 3 cases, acetabular wear in 3 cases, and stem loosening in 5 cases. In APC group, nonunion of APC occurred in 3 cases and acetabular wear in 1 case. At last follow-up, the average Musculoskeletal Tumor Society (MSTS) functional scores were 77.69% +/- 6.50% in prostheses group and 85.71% +/- 7.45% in APC group, showing significant difference (P < 0.001). CONCLUSION: When the wide resection is performed for malignant tumors of the proximal femur, better local control could be achieved. Compared with reconstruction of the prosthesis, the APC reconstruction can provide better function.
PMID: 20695391 [PubMed - in process]
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Contrast-enhanced ultrasound in the diagnosis of malignant mesenchymal liver tumors.
Fetched: August 17th, 2010, 9:13am CDT
Related Articles Contrast-enhanced ultrasound in the diagnosis of malignant mesenchymal liver tumors.
J Clin Ultrasound. 2010 Jun;38(5):227-31
Authors: Trojan J, Hammerstingl R, Engels K, Schneider AR, Zeuzem S, Dietrich CF
PURPOSE: Contrast-enhanced ultrasound can differentiate malignant from benign hepatic tumors, but has not been studied in malignant mesenchymal liver tumors. METHODS: We describe the findings of contrast-enhanced ultrasound in a cohort of five patients with histological-proven malignant hepatic mesenchymal tumors. RESULTS: The presence of imaging features such as peripheral (nodular) enhancement, chaotic central vascularization, and absence of contrast enhancement in the late phase allowed differentiation from hemangiomas. CONCLUSIONS: If these findings are demonstrated in large hepatic tumors, then the diagnosis of hemangioma is unlikely and further workup is necessary.
PMID: 20336772 [PubMed - indexed for MEDLINE]
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Diagnostic Exercise: Sudden Death in a Dog After Doxorubicin Chemotherapy.
Fetched: August 10th, 2010, 6:31pm CDT
Related Articles Diagnostic Exercise: Sudden Death in a Dog After Doxorubicin Chemotherapy.
Vet Pathol. 2010 Aug 3;
Authors: Banco B, Grieco V, Servida F, Giudice C
A case is reported of fatal cardiomyopathy in an 8-year-old female German Shepherd after standard chemotherapy with doxorubicin for splenic hemangiosarcoma. The main gross lesion was a moderate bilateral cardiac ventricular dilation with diffusely pale myocardium. Histological analysis revealed severe multifocal vacuolar degeneration of cardiomyocytes, myocytolysis, myofibril loss, myocardial fibrosis, and edema. Myocardial fiber vacuolization and myocytolysis were highly suggestive of doxorubicin cardiotoxicity.
PMID: 20682807 [PubMed - as supplied by publisher]
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Stewart-Treves syndrome of the lower extremity.
Fetched: August 10th, 2010, 6:31pm CDT
Related Articles Stewart-Treves syndrome of the lower extremity.
J Clin Oncol. 2010 Jul 20;28(21):e351-2
Authors: McHaffie DR, Kozak KR, Warner TF, Cho CS, Heiner JP, Attia S
PMID: 20368562 [PubMed - indexed for MEDLINE]
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[Images of primary hepatic angiosarcomas]
Fetched: August 10th, 2010, 6:31pm CDT
Related Articles [Images of primary hepatic angiosarcomas]
Zhonghua Gan Zang Bing Za Zhi. 2008 Feb;16(2):136-7
Authors: Zhou ML, Yan FH, Ye F, Xiong Z, Wang JH, Ji Y
PMID: 18304433 [PubMed - indexed for MEDLINE]
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Primary bone angiosarcoma in a patient with Gaucher disease.
Fetched: August 4th, 2010, 9:26am CDT
Related Articles Primary bone angiosarcoma in a patient with Gaucher disease.
Int J Hematol. 2010 Jul 27;
Authors: Zver S, Bracko M, Andoljsek D
Skeletal pain and the resulting skeletal complications are common in Gaucher disease. The patients therefore usually receive symptomatic treatment and only rarely undergo additional diagnostic procedures. The paper describes the case of a patient with Gaucher disease who had advancing pain in the right knee and femur, which was first attributed to the basic disease. After a pathological fracture of the painful part of the leg, it became evident that the patient suffered from primary bone angiosarcoma. From this case, we learnt that not every skeletal pain in Gaucher disease represents a skeletal manifestation of this disease. Further surgical treatment was made difficult by the thrombocyte dysfunction discovered in the patient.
PMID: 20661673 [PubMed - as supplied by publisher]
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Matrix metalloproteinase-1 expression in splenic angiosarcoma metastasizing to the serous membrane.
Fetched: August 4th, 2010, 9:26am CDT
Related Articles Matrix metalloproteinase-1 expression in splenic angiosarcoma metastasizing to the serous membrane.
Int J Clin Exp Pathol. 2010;3(6):634-9
Authors: Takeuchi T, Iwasaki S, Miyazaki J, Nozaki Y, Takahashi M, Ono M, Saibara T, Furihata M
Angiosarcoma involving the serous membrane may mimic mesothelioma; therefore, the term "pseudomesotheliomatous angiosarcoma" has been suggested for this entity. However, the pathogenesis of pseudomesotheliomatous angiosarcoma remains unclear. Here, we report an autopsy case of splenic angiosarcoma, which systemically metastasized to the serous membrane of both the peritoneum and pleura, closely resembling a mesothelioma. The spindle-shaped tumor cells exhibited marked invasion of the lymphatic vessels and invaded the serous membrane causing thickening of the fibrous tissues like desmoplastic mesothelioma. In the present case, immunohistochemical staining showed that the tumor expressed not only the endothelial cell markers, such as CD31, vascular endothelial growth factor receptor 3, and podoplanin (D2-40), but also matrix metalloproteinase-1 (also known as collagenase-1), which is known to increase the invasiveness of mesothelioma cells. MMP-1 expression was not observed in the other cases of angiosarcoma, examined. This tumor might systemically metastasize to the serous membrane via the lymphatic route and might generate the fibrous stroma aided by the matrix metalloproteinase-1.
PMID: 20661412 [PubMed - in process]
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Metastatic angiosarcoma arising from the right atrium: unusual presentation and excellent response to treatment in a young patient.
Fetched: August 4th, 2010, 9:26am CDT
Related Articles Metastatic angiosarcoma arising from the right atrium: unusual presentation and excellent response to treatment in a young patient.
J Thorac Oncol. 2010 Aug;5(8):1301-2
Authors: Fehr M, Kuhn M, Mayer K, Padberg B, Ulmer U, Cathomas R
PMID: 20661090 [PubMed - in process]
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Cardiac Sarcomas: An Update.
Fetched: August 4th, 2010, 9:26am CDT
Related Articles Cardiac Sarcomas: An Update.
J Thorac Oncol. 2010 Jul 21;
Authors: Orlandi A, Ferlosio A, Roselli M, Chiariello L, Spagnoli LG
Primary cardiac sarcomas are rare and represent 20% of all primary cardiac tumors. Symptoms depend on the chambers and the cardiac structures involved. Transthoracic echocardiography is commonly used to identify a cardiac mass. The diagnosis of cardiac sarcoma requires adequate sampling and the careful use of ancillary diagnostic techniques. In the most recent histologic classification, angiosarcoma is the most common malignant tumor of the heart with recognizable differentiation. Undifferentiated sarcomas account for one-third of all cardiac sarcomas and have been incorporated in the malignant fibrous histiocytoma/pleomorphic sarcoma subgroup. Elective cardiac sarcoma therapy includes complete surgical excision when possible, followed by radio and chemotherapeutic regimen, the latter preferably containing anthracyclines, ifosfamide, or taxanes. Prognosis of cardiac sarcomas is very poor, with mean survival ranging from 9.6 to 16.5 months. A less-aggressive course seems related to the left atrium location, a low histologic grading with scarce cellular pleomorphism and low-mitotic activity, absence of necrosis, myxoid tumor appearance, and absence of metastasis at diagnosis.
PMID: 20651614 [PubMed - as supplied by publisher]
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[Primary angiosarcoma of the pericardium: case report and review of the literature.]
Fetched: August 4th, 2010, 9:26am CDT
Related Articles [Primary angiosarcoma of the pericardium: case report and review of the literature.]
Kardiol Pol. 2010;68(7):802-805
Authors: Timóteo AT, Branco LM, Bravio I, Pinto E, Timoteo T, Matos P, Ferreira RC
Primary cardiac tumours are rare entities and angiosarcoma is the most frequent primary cardiac malignant tumour. Mean survival is six months and the tumour responds poorly to chemotherapy. We present the case of a 50 year-old patient with localised pericardial angiosarcoma who survived 23 months after diagnosis with a combined approach of chemotherapy and surgery. Kardiol Pol 2010; 68, 7: 802-805.
PMID: 20648441 [PubMed - as supplied by publisher]
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Primary vascular tumors of the lungs: a review.
Fetched: August 4th, 2010, 9:26am CDT
Related Articles Primary vascular tumors of the lungs: a review.
Ann Diagn Pathol. 2010 Aug;14(4):296-308
Authors: Weissferdt A, Moran CA
Unlike their counterparts in other organ systems, primary vascular neoplasms of the lung are rare. Most of these lesions have only been reported as isolated case studies or small series. When dealing with malignant lesions, metastasis from extrapulmonary sites will have to be excluded before a primary location in the lungs can be confirmed. In this review, the clinicopathologic, immunophenotypical, ultrastructural, and molecular biologic characteristics of primary vascular tumors of the lungs are discussed. The tumoral conditions that will be addressed include hemangioma, lymphangioma, epithelioid hemangioendothelioma, angiosarcoma, and Kaposi's sarcoma. Their respective differential diagnoses will also be discussed.
PMID: 20637438 [PubMed - in process]
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Sinonasal angiosarcoma? Not likely (a brief description of infarcted nasal polyps).
Fetched: August 4th, 2010, 9:26am CDT
Related Articles Sinonasal angiosarcoma? Not likely (a brief description of infarcted nasal polyps).
Ann Diagn Pathol. 2010 Aug;14(4):233-4
Authors: Heffner DK
PMID: 20637425 [PubMed - in process]
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Primary tumor of the heart. Angiosarcoma.
Fetched: August 4th, 2010, 9:26am CDT
Primary tumor of the heart. Angiosarcoma.
Indian Heart J. 2009 Jul-Aug;61(4):383
Authors: Bansal M, Mehrotra R, Agrawal V, Kasliwal RR, Trehan N
PMID: 20635745 [PubMed - in process]
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Metastatic cutaneous angiosarcoma complicated with severe thrombocytopenia.
Fetched: August 4th, 2010, 9:26am CDT
Related Articles Metastatic cutaneous angiosarcoma complicated with severe thrombocytopenia.
Eur J Dermatol. 2010 Jul 16;
Authors: Kluger N, Girard C, Boissier E, Sibille L, Mariano-Goulart D, Guillot B
PMID: 20634170 [PubMed - as supplied by publisher]
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Cutaneous epithelioid angiosarcoma occurring at a peristomal site.
Fetched: August 4th, 2010, 9:26am CDT
Related Articles Cutaneous epithelioid angiosarcoma occurring at a peristomal site.
J Am Acad Dermatol. 2010 Aug;63(2):e55-6
Authors: Fessa CK, Sharma R, Fernández-Peñas P
PMID: 20633792 [PubMed - in process]
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Angiosarcoma mimicking rhinophyma.
Fetched: August 4th, 2010, 9:26am CDT
Related Articles Angiosarcoma mimicking rhinophyma.
Dermatol Res Pract. 2010;2010:365173
Authors: Lo Presti M, Mazzella C, Monfrecola A, Falleti J
We report the case of a 61-year-old man showing persistent erythematous macules, plaques, and partially confluent nodules with irregular borders, developed on his nose for one year. During that time the patient underwent several dermatological consultations, and all produced the same diagnosis: rhinophyma. So antibiotic and steroid treatment was carried out without any improvement while the lesions kept growing. When the patient came to our observation, physical examination revealed large, infiltrative, oedematous, erythematous plaques and rare nodules, with superficial telangiectatic vessels. Cervical lymphadenopathy was not detectable. Routine laboratory analysis was normal. Punch biopsy was performed, and histopathology and immunohistochemical studies were consistent with cutaneous angiosarcoma. This is the report of a face angiosarcoma with an unusual and very deceptive clinical presentation.
PMID: 20631905 [PubMed - in process]
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Cardiac angiosarcoma and recurrent pericardial effusion.
Fetched: August 4th, 2010, 9:26am CDT
Related Articles Cardiac angiosarcoma and recurrent pericardial effusion.
South Med J. 2010 Aug;103(8):849-50
Authors: Kaushik M, Alla VM, Pasupuleti S, Hunter C, Shatat L, Hunter WJ
PMID: 20622718 [PubMed - in process]
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[Cutaneous angiosarcoma with difficulty in differential diagnosis of thrombocytopenia]
Fetched: August 4th, 2010, 9:26am CDT
Related Articles [Cutaneous angiosarcoma with difficulty in differential diagnosis of thrombocytopenia]
Rinsho Ketsueki. 2010 Jun;51(6):402-6
Authors: Maeda T, Uchino K, Otani T, Ueda Y
An 87-year-old man was referred to our hospital because of sustained bleeding from head skin lesions after trauma. Examination of peripheral blood showed severe thrombocytopenia, a nearly normal coagulation test, and elevated PAIgG. Based on the tentative diagnosis of immune thrombocytopenic purpura (ITP), immunosuppressive drugs and high-dose immunoglobulin were administered; however, the platelet count did not recover, and was followed by severe DIC, resulting in a fatal outcome due to massive bleeding from the scalp. Histopathological examination of autopsy samples of skin lesions revealed angiosarcoma, suggesting that Kasabach-Merritt syndrome (KMS) complicated with DIC, but not ITP, was the primary cause of thrombocytopenia. Although KMS is commonly accompanied with hemangioma in infants, it is extremely rare in patients with angiosarcoma, which is an uncommon malignant neoplasm. In this case, our correct diagnosis of thrombocytopenia was difficult because of the unusual clinical setting, indicating that careful interpretation of physical, laboratory and pathological examinations is mandatory for correct diagnosis of thrombocytopenia of unknown etiology.
PMID: 20622486 [PubMed - in process]
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[Splenic pathology. Case 5. Splenic angiosarcoma]
Fetched: August 4th, 2010, 9:26am CDT
Related Articles [Splenic pathology. Case 5. Splenic angiosarcoma]
Ann Pathol. 2010 Jun;30(3):223-7
Authors: Stanislas S
PMID: 20621601 [PubMed - in process]
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[Sclerosing rhabdomyosarcoma: a clinicopathologic study of four cases with review of literature]
Fetched: August 4th, 2010, 9:26am CDT
Related Articles [Sclerosing rhabdomyosarcoma: a clinicopathologic study of four cases with review of literature]
Zhonghua Bing Li Xue Za Zhi. 2007 Sep;36(9):587-91
Authors: Zhu L, Wang J
OBJECTIVE: To study the clinicopathologic characteristics of sclerosing rhabdomyosarcoma (SRMS) and its distinction from embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS). METHODS: The clinical, histologic and immunohistochemical features of 4 cases of SRMS were studied. The literature was reviewed. RESULTS: All the 4 cases occurred in adults. The age of patients ranged from 20 to 54 years (mean = 41.5 years). The male-to-female ratio was 1:1. The tumor was located in the left wrist, right thigh, right face and right cheek respectively and the tumor size varied from 2.5 cm to 10 cm in dimension (mean = 5.7 cm). Histologically, SRMS was characterized by the presence of large amounts of heavily hyalinized matrix, mimicking osteoid or chondroid tissue. The tumor cells were composed predominantly of primitive small round cells which were arranged in diverse growth patterns, including fascicular, cord-like, single-file, trabecular, microalveolar and pseudovascular structures. A few rhabdomyoblasts were identified in 1 case. A second spindle cell component was focally found in 2 cases, resembling spindle cell rhabdomyosarcoma or peripheral nerve sheath tumor. Immunohistochemically, all cases showed diffuse staining for Myo D1 and focal staining for desmin. The staining for myogenin was often negative. Three of the cases also expressed muscle-specific actin and 2 cases were positive for alpha-smooth muscle actin. They were all negative for h-caldesmon, S-100 protein, CD31, CD34, AE1/AE3 and anaplastic lymphoma kinase protein. CONCLUSIONS: SRMS differs from ERMS and ARMS morphologically. Recent cytogenetic studies however suggest a histogenetic relationship with ERMS. Familiarity with its morphologic features and immunophenotype may help to distinguish this peculiar variant of rhabdomyosarcoma from a variety of lesions with abundant sclerosing matrix.
PMID: 18070445 [PubMed - indexed for MEDLINE]
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Primary cardiac sarcoma.
Fetched: July 11th, 2010, 1:34pm CDT
Related Articles Primary cardiac sarcoma.
Ann Thorac Surg. 2010 Jul;90(1):176-81
Authors: Hamidi M, Moody JS, Weigel TL, Kozak KR
BACKGROUND: The presentation, management, and outcome of patients with primary cardiac sarcomas are not well defined. Furthermore, the role of adjuvant therapy has not been delineated in the management of primary cardiac sarcomas. METHODS: Patients with primary cardiac sarcoma and noncardiac sarcoma, diagnosed between 1988 and 2005, were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Clinical characteristics and outcomes of primary cardiac sarcoma were defined and compared with the characteristics of noncardiac sarcomas. Univariate and multivariate methods were used to identify factors associated with primary cardiac sarcoma survival. RESULTS: Compared with noncardiac sarcomas, primary cardiac sarcomas were found to occur in a younger age group and were more likely to present with advanced disease. Primary cardiac sarcomas were ten times more likely to be vessel-derived (eg, angiosarcoma), comprising almost half of all cases. Median overall survival for cardiac sarcoma patients was 6 months whereas that for noncardiac sarcoma patients was significantly longer at 93 months (p < 0.001). Furthermore, cardiac sarcoma patients who underwent surgery had a median survival of 12 months whereas those who did not undergo surgery had a median survival of 1 month (p < 0.001). CONCLUSIONS: Cardiac sarcomas are a distinct, rare subset of soft tissue sarcomas with a poor prognosis. Surgery continues to be the central component of successful management. Future clinical efforts should be directed at developing approaches to permit safe radical excision and, potentially, developing effective adjuvant therapy.
PMID: 20609770 [PubMed - in process]
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Fatal poorly differentiated angiosarcoma of the scalp.
Fetched: July 11th, 2010, 1:34pm CDT
Related Articles Fatal poorly differentiated angiosarcoma of the scalp.
Int J Clin Exp Pathol. 2010;3(5):541-4
Authors: Terada T
Cutaneous angiosarcoma is a very rare but aggressive tumor. Angiosarcoma of the scalp is very rare, and a review of the world literature revealed less than 60 cases. Here, the author reports a case of poorly differentiated angiosarcoma of the scalp. The pathological diagnosis was very difficult. A 70-year-old Japanase man was admitted to our hospital complaining of red mass of the scalp. An excisional biopsy was done. The biopsy showed proliferation of malignant spindle cells in the dermis. Apparent differentiation was not recognized. Invasion into the lateral dermis and subcutis was recognized. There were many mitotic figures and a few foci of necrosis. The size was 2 x 2 x 3 cm. Intracytoplasmic vacuoles were recognized in the malignant tumor cells in some places. A few vague vasoformative features were recognized in one very small area. Immunohistochemically, the malignant spindle cells were positive for factor VIII-related antigen (F-VIII-RA), Ulex lectin, CD31, CD34, vimentin, p53 protein. The Ki-67 labeling was 76%. In contrast, the tumor cells were negative for cytokeratins, epithelial membrane antigen, desmin, S100 protein, alpha-smooth muscle antigen, bcl-2, melanosome, and myoglobin. The intracytoplasmic vacuoles were strongly positive for F-VIII-RA, Ulex lectin, CD31, and CD34, The abortive vasoformative channels were moderately positive for these endothelial markers. A pathologic diagnosis of angiosarcoma of the scalp was made. Chemoradiation and immunotherapy were performed. However, the tumor recurred several times, and ultimately metastasized to the systemic bones and lungs. The patient died of systemic carcinomatosis 33 months after the first manifestation.
PMID: 20606736 [PubMed - in process]
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A case of retiform-hemangioendothelioma with unusual presentation and aggressive clinical features.
Fetched: July 11th, 2010, 1:34pm CDT
Related Articles A case of retiform-hemangioendothelioma with unusual presentation and aggressive clinical features.
Int J Clin Exp Pathol. 2010;3(5):528-33
Authors: Zhang G, Lu Q, Yin H, Wen H, Su Y, Li D, Xiao R
Retiform hemangioendothelioma (RH) is an extremely rare low-grade angiosarcoma mainly involving the skin and subcutaneous tissue. Clinically patients often present with an asymptomatic slow-growing solitary nodular or plaque-like lesion. RH is characterized by frequent local recurrences but a very low metastatic rate. Here we reported a case of RH in a 61-year-old Chinese woman who presented with a rapid growing cutaneous plaque-like lesion on her right scalp, followed by another lesion behind the right ear. The lesions were associated with paroxysmal sharp needle-stabbing like headache. She underwent wide excision and skin engraftment. Three months post surgery, she experienced tumor recurrence, and died 9 months after the initial diagnosis.
PMID: 20606734 [PubMed - in process]
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Pseudoangiomatous stromal hyperplasia: an overview.
Fetched: July 11th, 2010, 1:34pm CDT
Related Articles Pseudoangiomatous stromal hyperplasia: an overview.
Arch Pathol Lab Med. 2010 Jul;134(7):1070-4
Authors: Virk RK, Khan A
Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign, proliferative mesenchymal lesion with possible hormonal etiology. It typically affects women in the reproductive age group. Pseudoangiomatous stromal hyperplasia is frequently an incidental histologic finding in breast biopsies performed for other benign or malignant lesions. Rarely, it can present as a firm, painless breast mass, which has been referred to as nodular or tumorous PASH. Grossly, tumorous PASH is a well-circumscribed, firm, rubbery mass with solid, homogenous, gray-white cut surface. On histologic examination, it is characterized by the presence of open slitlike spaces in dense collagenous stroma. The spaces are lined by a discontinuous layer of flat, spindle-shaped myofibroblasts with bland nuclei. The spindle cells express progesterone receptors and are positive for vimentin, actin, and CD34. The most important differential diagnosis on histopathology is angiosarcoma. Pseudoangiomatous stromal hyperplasia discovered incidentally does not require any additional specific treatment. Tumorous PASH is treated by local surgical excision with clear margins and the prognosis is excellent, with minimal risk of recurrence after adequate surgical excision.
PMID: 20586640 [PubMed - in process]
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Endomyocardial biopsy of right atrial angiosarcoma guided by intracardiac echocardiography.
Fetched: July 11th, 2010, 1:34pm CDT
Related Articles Endomyocardial biopsy of right atrial angiosarcoma guided by intracardiac echocardiography.
Cardiol Res Pract. 2010;2010:681726
Authors: Kuppahally SS, Litwin SE, Michaels AD
We report a case of a 22-year-old female who presented with pericardial effusion and cardiac tamponade. She was diagnosed with a right atrial mass by computed tomography and was referred to our institution for biopsy of this mass. Transcatheter biopsy was performed with intracardiac echocardiography (ICE) guidance, avoiding the need for transesophageal echocardiography or surgery to obtain the biopsy. ICE for transcatheter biopsy of an intracardiac mass is an attractive modality which provides precise localization of the cardiac structures.
PMID: 20585357 [PubMed - in process]
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Postoperative radiotherapy for cervix cancer incidentally discovered after a simple hysterectomy for either benign conditions or noninvasive pathology.
Fetched: July 11th, 2010, 1:34pm CDT
Related Articles Postoperative radiotherapy for cervix cancer incidentally discovered after a simple hysterectomy for either benign conditions or noninvasive pathology.
Am J Clin Oncol. 2010 Jun;33(3):229-32
Authors: Smith KB, Amdur RJ, Yeung AR, Morris CG, Kirwan J, Morgan LS
OBJECTIVE: Report the long-term outcome of patients who received postoperative radiotherapy for incidentally discovered cervix cancer following simple hysterectomy. METHODS: We recorded tumor status, treatment complications, and survival of 25 patients treated at our institution from 1961 to 2004 with postoperative RT for invasive cervix cancer discovered following simple hysterectomy (median follow-up, 17 years). All patients had stage IA2-II squamous cell carcinoma (76%) or adenocarcinoma (24%) of the cervix. RESULTS: One patient had an isolated vaginal-cuff recurrence and was cured long-term with salvage surgery. No patient died of cervix cancer. The actuarial rate of tumor control and relapse-free survival at 5, 10, and 20 years was 96%. One patient died of a treatment-related complication. Cause-specific survival was 100% at 5 and 10 years, but 92% at 20 years. Overall survival was 100% at 5 years, 95% at 10 years, and 62% at 20 years.The complications rate from therapy was surprising. The overall grade 2 to 5 complications rate was 36% (9 of 25). Twenty percent (5 of 25) of patients experienced grade 4 or 5 complications. CONCLUSIONS: This series demonstrates the price we pay for adding comprehensive radiotherapy to simple hysterectomy for early-stage cervix cancer. The findings support 2 recommendations: (1) Avoid postoperative radiotherapy by aggressively screening patients for invasive disease before performing simple hysterectomy. (2) Raise the threshold for delivering pelvic radiotherapy following simple hysterectomy with an incidental diagnosis of invasive cervix cancer. We recommend vaginal brachytherapy alone in patients with negative postoperative imaging, negative surgical margins, and <10 mm tumor invasion.
PMID: 19806037 [PubMed - indexed for MEDLINE]
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[Ultrasonographic findings and treatment in a cow with a haemangiosarcoma of the urinary bladder]
Fetched: July 11th, 2010, 1:34pm CDT
Related Articles [Ultrasonographic findings and treatment in a cow with a haemangiosarcoma of the urinary bladder]
Schweiz Arch Tierheilkd. 2009 Oct;151(10):490-4
Authors: Braun U, Tschuor AC, Hilbe M, Lange CE, Schwarzwald C
A 4.5-year-old Swiss Braunvieh cow was presented to the Department of Farm Animals, University of Zurich, because of severe haematuria. All other clinical findings were within normal ranges. Transrectal ultrasonography revealed a 1 cm x 1 cm echogenic, irregularly-shaped, raised mass in the wall of the urinary bladder. Endoscopy identified the mass as a proliferation, approximately 0.5 cm in diameter, which was bleeding continuously. Thermocautery of the bleeding site was carried out twice five days apart via endoscopy. Clinical signs resolved for the remainder of the cow's life; she was slaughtered 15 months later because of infertility. Histological examination of the mass revealed a haemangiosarcoma.
PMID: 19780010 [PubMed - indexed for MEDLINE]
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Promontory Sign in a Reactive Benign Vascular Proliferation.
Fetched: June 26th, 2010, 9:50am CDT
Related Articles Promontory Sign in a Reactive Benign Vascular Proliferation.
Am J Dermatopathol. 2010 Jun 24;
Authors: Fernandez-Flores A, Rodriguez R
The promontory sign was described 27 years ago and it was claimed to be useful in the diagnosis of early stages of Kaposi sarcoma. However, it is not pathognomonic, because it has also been described in angiosarcoma and in benign vascular tumors. Some authors claim that some reactive vascular lesions known as pseudo-Kaposi do not present the promontory sign. We report the case of a vascular cutaneous lesion on the breast of a 75-year-old woman, which had a benign clinical behavior, and presented with the promontory sign. The lesion was made of tortuous dilated lymphatic tissue, and small capillaries with a lobular distribution. It was characterized by CD31 and D240 immunostaining, although no immunostaining for human herpesvirus 8 (HHV8) was found. The lesion spontaneously improved and eventually disappeared. It was thought to be secondary to a chronic trauma to the area due to a prolonged stance in bed in the emergency room.
PMID: 20577080 [PubMed - as supplied by publisher]
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Angiosarcoma of the Eyelid: A Clinicopathologic Comparison Between Isolated Unilateral Tumors and Tumors Demonstrating Extrapalpebral Involvement.
Fetched: June 26th, 2010, 9:50am CDT
Related Articles Angiosarcoma of the Eyelid: A Clinicopathologic Comparison Between Isolated Unilateral Tumors and Tumors Demonstrating Extrapalpebral Involvement.
Am J Dermatopathol. 2010 Jun 17;
Authors: Papalas JA, Manavi CK, Woodward JA, Sangueza OP, Cummings TJ
Angiosarcomas involving the head and neck are malignant tumors which tend to involve multiple anatomical structures with an overall dismal prognosis. Reports of primary, isolated eyelid involvement are rare. We report 4 cases of angiosarcoma involving the eyelid as either an isolated tumor or as part of a more diffuse malignant process and compare the features of these 2 tumor types to cases reported in the literature. The mean age at which patients develop angiosarcoma involving the eyelid was 72. Patients with isolated tumors most often presented complaining of a discrete mass clinically resembling a stye. Patients with isolated eyelid involvement had better survival (100% at 3.2 years) compared with patients with diffuse disease (57% at 3.3 years). Those with isolated eyelid involvement have an average tumor size of 2.08 cm with no distant metastasis. Patients who have eyelid angiosarcoma with extrapalpebral involvement have tumors ranging between 5 and 10 cm on average and 21% develop metastases. True isolated angiosarcoma of the eyelid is rare. When extrapalpebral involvement is ruled out by clinical and radiographic examination, patients with isolated involvement seem to fare better compared with patients with eyelid involvement secondary to more regionally extensive tumors.
PMID: 20559124 [PubMed - as supplied by publisher]
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Hepatic angiosarcoma arising in an adult mesenchymal hamartoma.
Fetched: June 26th, 2010, 9:50am CDT
Related Articles Hepatic angiosarcoma arising in an adult mesenchymal hamartoma.
Indian J Pathol Microbiol. 2010 Apr-Jun;53(2):322-4
Authors: Kulkarni MP, Agashe SR, Singh RV, Sulhyan KR
Embryonal (undifferentiated) sarcomas arising in mesenchymal hamartoma are on record but cases of hepatic angiosarcoma (AS) arising in mesenchymal hamartoma (MH) of the liver are extremely rare. We report one such case in a 20-year-old male patient. He presented with a lump in the right hypochondriac region and pain of two years duration with rapid increase in size since two months. Ultrasonography (USG) revealed a well circumscribed mass on the undersurface of the right lobe of liver suggestive of hemangioma. The patient underwent resection of the mass. Histopathology revealed AS with areas of MH.
PMID: 20551545 [PubMed - in process]
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Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver.
Fetched: June 26th, 2010, 9:50am CDT
Related Articles Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver.
J Gastroenterol Hepatol. 2010 May;25(5):1016
Authors: Schwartz J, Hatch J, Shaaban A, Hutson W
PMID: 20546460 [PubMed - in process]
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Contrast-enhanced ultrasonography for characterization of canine focal liver lesions.
Fetched: June 26th, 2010, 9:50am CDT
Related Articles Contrast-enhanced ultrasonography for characterization of canine focal liver lesions.
Vet Radiol Ultrasound. 2010 Jan-Feb;51(1):79-85
Authors: Nakamura K, Takagi S, Sasaki N, Bandula Kumara WR, Murakami M, Ohta H, Yamasaki M, Takiguchi M
In six normal beagles and 27 dogs with spontaneous focal or multifocal liver lesions, contrast-enhanced ultrasonography using Sonazoid was performed. Sonazoid is a newly developed second-generation contrast agent with the ability to be used for real-time contrast imaging along with parenchymal imaging. An appropriate protocol for the evaluation of all three phases (arterial, portal, and parenchymal) was established based on the results for normal beagles. By evaluation of the echogenicity of hepatic nodules during the arterial and parenchymal phases it was possible to differentiate malignant tumors from benign nodules with very high accuracy. In 15 of 16 dogs diagnosed as malignant tumors, nodules were clearly hypoechoic to the surrounding normal liver during the parenchymal phase. Additionally, malignant tumors had different echogenicity compared with the surrounding normal liver during the arterial phase in 14 of 15 dogs. In the portal phase, there were no characteristic findings. Contrast-enhanced ultrasonography with Sonazoid appears to improve the characterization of canine focal and multifocal hepatic lesions.
PMID: 20166400 [PubMed - indexed for MEDLINE]
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[Recent advances of hemangioendothelioma (borderline vascular tumors)]
Fetched: June 26th, 2010, 9:50am CDT
Related Articles [Recent advances of hemangioendothelioma (borderline vascular tumors)]
Zhonghua Bing Li Xue Za Zhi. 2007 May;36(5):339-41
Authors: Gong QX, Fan QH
PMID: 17706145 [PubMed - indexed for MEDLINE]
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PML down-regulation in soft tissue sarcomas.
Fetched: June 26th, 2010, 9:50am CDT
Related Articles PML down-regulation in soft tissue sarcomas.
J Cell Physiol. 2010 Apr 29;224(3):644-648
Authors: Vincenzi B, Perrone G, Santini D, Grosso F, Silletta M, Frezza A, Rossi S, Russo A, Rabitti C, Gebbia N, Badalamenti G, Casali P, Muda AO, Dei Tos AP, Tonini G
To date, little is known concerning the promyelocytic leukemia gene (PML) status in tumors of different origin, and its expression has never been evaluated in soft tissue sarcoma. The aim of the present study is focused on the identification of differences in terms of PML protein expression between different types of soft tissue sarcoma and the corresponding normal surrounding tissue. PML protein expression has been assessed by immunohistochemistry in six different histologic types of soft tissue sarcoma (synovial sarcoma, myofibroblastic sarcoma, angiosarcoma, liposarcoma, pleomorphic sarcoma, and leiomyosarcoma) and in the corresponding normal surrounding tissue. PML resulted significantly down-regulated in synovial sarcoma and in myofibroblastic sarcoma specimens. Also in angiosarcoma samples a significative difference in PML expression in comparison with normal specimens has been detected. Interestingly PML protein detection showed a different pattern of expression in the three liposarcoma histology types compared with corresponding nontumoral tissues. In particular PML protein resulted significantly down-regulated in myxoid liposarcoma and in dedifferentiated liposarcoma. On the contrary no statistically significant difference was observed in pleomorphic liposarcoma compared to normal tissue specimens. Further investigations are needed to confirm these data and to assess the possible value of PML expression as a prognostic factor in these extremely aggressive diseases. J. Cell. Physiol. 224: 644-648, 2010. (c) 2010 Wiley-Liss, Inc.
PMID: 20578240 [PubMed - as supplied by publisher]
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Epithelioid Angiosarcoma of the Lung with Pleural Metastases: A Rare Cause of Haemoptysis Clinicopathological Conference.
Fetched: June 15th, 2010, 3:51pm CDT
Related Articles Epithelioid Angiosarcoma of the Lung with Pleural Metastases: A Rare Cause of Haemoptysis Clinicopathological Conference.
Heart Lung Circ. 2010 Jun 9;
Authors: Carillo GA, Carretero MA, Vazquez JE, Fontan EG, Ramos MB, Ventura JA, Rodriguez AP, Salmon AS, Tejedor JL
Angiosarcomas are a rare type of malignant vascular tumour characterised by proliferation of tumour cells with vascular endothelial features. These tumours are usually very aggressive and overall mortality is very high. Pulmonary angiosarcomas are usually secondary tumours, and only a few primary cases have been reported. We present a case of a 56-year-old male with persistent haemoptysis secondary to lung epithelioid angiosarcoma with pleural metastases.
PMID: 20541463 [PubMed - as supplied by publisher]
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Angiosarcoma.
Fetched: June 15th, 2010, 3:51pm CDT
Related Articles Angiosarcoma.
Lancet Oncol. 2010 May 25;
Authors: Young RJ, Brown NJ, Reed MW, Hughes D, Woll PJ
Angiosarcomas are rare soft-tissue sarcomas of endothelial cell origin that have a poor prognosis. They can arise anywhere in the body, most commonly presenting as cutaneous disease in elderly white men, involving the head and neck and particularly the scalp. They can be caused by therapeutic radiation or chronic lymphoedema and hence secondary breast angiosarcomas are an important subgroup. Recent work has sought to establish the molecular biology of angiosarcomas and identify specific targets for treatment. Interest is now focused on trials of vascular-targeted drugs, which are showing promise in the control of angiosarcomas. In this review we discuss angiosarcoma and its current management, with a focus on clinical trials investigating the treatment of advanced disease.
PMID: 20537949 [PubMed - as supplied by publisher]
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Primary Vascular Tumors and Tumor-like Lesions of the Kidney: A Clinicopathologic Analysis of 25 Cases.
Fetched: June 15th, 2010, 3:51pm CDT
Related Articles Primary Vascular Tumors and Tumor-like Lesions of the Kidney: A Clinicopathologic Analysis of 25 Cases.
Am J Surg Pathol. 2010 Jun 8;
Authors: Brown JG, Folpe AL, Rao P, Lazar AJ, Paner GP, Gupta R, Parakh R, Cheville JC, Amin MB
Vascular tumors of the kidney are distinctly rare, and to date no large series have been reported. We analyzed a series of primary vascular tumors of the kidney to further delineate their clinicopathologic features and identify organ-specific morphologic features, if present. Twenty-five renal cases previously coded as "arteriovenous malformation," "hemangioma," and "angiosarcoma" were retrieved from the archives of 4 collaborating institutions and were reevaluated histologically. Tumors were classified according to the 2002 World Health Organization classification of tumors of soft tissue and bone. There were 18 males and 7 females (M:F=2.6:1) ranging from 21 to 95 years (mean 56.7 y). Lesions ranged from "microscopic" to 30 cm (mean 6.0 cm) and were tan-brown, cystic, and hemorrhagic. On re-review, cases were classified as arteriovenous malformation (n=3), capillary hemangioma (n=14), and angiosarcoma (n=8). Arteriovenous malformations were identical to their somatic soft tissue counterparts. Renal capillary hemangiomas often lacked a well-formed lobular pattern and 5 cases showed a "sieve-like" arrangement reminiscent of splenic sinusoids, a pattern previously noted by others (anastomosing hemangioma). All hemangiomas were noninfiltrative and lacked cytologic atypia and mitotic activity. GLUT-1, D2-40, and CD8 were performed in 3 anastomosing hemangiomas and were all negative. Angiosarcomas were diffusely infiltrative with extensive parenchymal destruction; all showed at least small areas of conventional vasoformative growth, but were frequently dominated by spindled and epithelioid histology. All cases were positive for some combination of vascular tumor-associated markers (CD31, CD34, and FLI-1). Cytokeratin expression was absent in all angiosarcomas. Follow-up was available for 15 cases: all patients with arteriovenous malformation and hemangioma with follow-up were disease free after complete excision; 4 cases of angiosarcoma died of the disease at 1, 1, 6, and 11 months. Our review shows that many capillary hemangiomas of the kidney are morphologically distinctive tumors, which often show "spleen-like" or "anastomosing" features. Angiosarcomas of the kidney are highly aggressive tumors with poor outcome and may have morphologic features (spindling and epithelioid change), which could result in confusion with sarcomatoid carcinomas and other renal mesenchymal tumors.
PMID: 20534992 [PubMed - as supplied by publisher]
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Synchronous angiosarcoma, melanoma and morphea of the breast skin 14 years after radiotherapy for mammary carcinoma.
Fetched: June 15th, 2010, 3:51pm CDT
Related Articles Synchronous angiosarcoma, melanoma and morphea of the breast skin 14 years after radiotherapy for mammary carcinoma.
Acta Derm Venereol. 2010 May;90(3):283-6
Authors: de Giorgi V, Santi R, Grazzini M, Papi F, Gori A, Rossario S, Massi D, Lotti T
With the improvement in survival after breast cancer there has been increasing interest in the long-term effects of radiotherapy, including the development of tumours. Compared with the general population, breast cancer survivors have a 10-50% higher risk of developing a second cancer. Radiotherapy may play a role in the onset of such lesions. We describe here the case of a 68-year-old woman who developed synchronous cutaneous angiosarcoma, melanoma and morphea of the breast skin and the local area, 14 years after radiotherapy for breast carcinoma. Given the risk of post-radiation secondary primaries in breast cancer patients, long-term surveillance is necessary, with particular attention being paid to skin changes in the irradiation field. Radiation-induced morphea is a rare complication in which immunological abnormalities may stimulate malignant transformation. Long-term studies are required to clarify the pathogenesis of these rare associations.
PMID: 20526547 [PubMed - in process]
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Tumors of the heart.
Fetched: June 15th, 2010, 3:51pm CDT
Related Articles Tumors of the heart.
Future Cardiol. 2010 Mar;6(2):181-93
Authors: Sheppard MN, Mohiaddin R
Cardiac Tumors are very rare but have devastating consequences given that they involve such an important organ. The majority of tumors are benign myxomas, which can present in very subtle ways causing a subsequent delay in diagnosis. Routine echocardiography is advised for anybody who is feeling generally unwell, since myxomas can cause pyrexia of unknown origin. The use of cardiac imaging has increased the early diagnosis of these tumors. A total of 25% of cardiac tumors are malignant sarcomas and these have a highly aggressive behavior. Early detection of these tumors while they are resectable offers a possibility for cure in the future.
PMID: 20230260 [PubMed - indexed for MEDLINE]
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Mediastinal germ cell tumors with an angiosarcomatous component: a report of 12 cases.
Fetched: June 15th, 2010, 3:51pm CDT
Related Articles Mediastinal germ cell tumors with an angiosarcomatous component: a report of 12 cases.
Hum Pathol. 2010 Jun;41(6):832-7
Authors: Contreras AL, Punar M, Tamboli P, Tu SM, Pisters L, Moran C, Czerniak BA, Guo CC
The development of an angiosarcomatous component in germ cell tumors is rare. Here we studied 12 cases of mediastinal germ cell tumors with an angiosarcomatous component. All patients were men with a mean age of 34 years (range, 24-49 years). No patient had a documented testicular germ cell tumor. The mean size of mediastinal tumors was 12.9 cm (range, 5.5-16.0 cm). Grossly, the tumors were cystic with variegated hemorrhagic, mucinous, and fleshy solid areas. Microscopically, all tumors were composed of germ cell tumor. The most common germ cell tumor component was teratoma (n = 10); and other germ cell tumor components included seminoma (n = 3), yolk sac tumor (n = 3), embryonal carcinoma (n = 2), and choriocarcinoma (n = 1). The angiosarcomatous component was present in primary mediastinal tumors (n = 6), metastasis (n = 3), or both primary mediastinal tumor and metastasis (n = 3). The angiosarcomatous component accounted for an average of 30% (range, 5%-95%) of the primary mediastinal tumor. In addition, other non-germ cell components, including rhabdomyosarcoma (n = 3), leiomyosarcoma (n = 1), and poorly differentiated carcinoma (n = 1), were also present in the tumors. Of the 10 patients with follow-up available, all patients developed metastasis (n = 8) or local recurrence (n = 2); 7 died of disease at a mean of 33 months (range, 21-75 months), and 3 patients were alive at a mean of 75 months (range, 5-120 months). Our findings suggest that the presence of an angiosarcomatous component in mediastinal germ cell tumor, even in a small amount, is associated with a poor clinical outcome.
PMID: 20153508 [PubMed - indexed for MEDLINE]
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Future treatment of soft tissue sarcomas will be driven by histological subtype and molecular aberrations.
Fetched: June 15th, 2010, 3:51pm CDT
Related Articles Future treatment of soft tissue sarcomas will be driven by histological subtype and molecular aberrations.
Eur J Cancer. 2010 Mar;46(5):863-8
Authors: Verweij J, Baker LH
Soft tissue sarcomas, although sharing a mesenchymal origin, are a heterogeneous group of diseases. Nevertheless they are studied and frequently treated as if they were all the same. Recent developments suggest that a different approach may be more adequate. Genetic profiling studies have indicated that some soft tissue sarcoma subtypes, despite a distinct histo-pathological difference, may be closely related. Molecular biology research in addition has identified several subtype-specific oncogenes and their protein products that could serve as treatment targets. Since many of the new molecularly targeted agents do not induce tumour regression, but mainly result in growth inhibition, it is therefore necessary also to change the study end-point in screening studies in the search for active treatments. In view of all these it is proposed to consider using alternative end-points such as progression-free rates at pre-set times, or progression arrest at first evaluation. By using databases from large cooperative groups it should be possible to identify progression arrest rates for each specific subtype, and these could serve as reference for future trial design. Soft tissue sarcoma treatment and research will require a change of approach and necessitate global cooperation.
PMID: 20138507 [PubMed - indexed for MEDLINE]
Trial - Angiosarcoma
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Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma
Posted: August 25th, 2010, 9:00am CDT
Condition: Sarcoma
Interventions: Drug: doxorubicin hydrochloride; Drug: trabectedin; Other: laboratory biomarker analysis; Procedure: quality-of-life assessment
Sponsor: European Organization for Research and Treatment of Cancer
Not yet recruiting - verified August 2010 -
GDC-0449 and RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma
Posted: June 29th, 2010, 9:00am CDT
Conditions: Adult Malignant Fibrous Histiocytoma of Bone; Gastrointestinal Stromal Tumor; Kidney Cancer; Malignant Conjunctival Neoplasm; Ovarian Cancer; Sarcoma; Small Intestine Cancer
Interventions: Drug: Hedgehog antagonist GDC-0449; Drug: gamma-secretase inhibitor RO4929097
Sponsors: Memorial Sloan-Kettering Cancer Center; National Cancer Institute (NCI)
Recruiting - verified June 2010 -
Paclitaxel + Bevacizumab (Avastin®) for the Treatment of Metastatic or Unresectable Angiosarcoma
Posted: January 21st, 2010, 9:00am CST
Conditions: Hemangiosarcoma; Soft Tissue Sarcoma
Intervention: Drug: Paclitaxel in combination with Bevacizumab
Sponsors: Stanford University; Genentech
Recruiting - verified July 2010 -
Vorinostat and Bortezomib in Treating Patients With Advanced Soft Tissue Sarcoma
Posted: July 10th, 2009, 9:00am CDT
Condition: Sarcoma
Interventions: Drug: bortezomib; Drug: vorinostat
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Active, not recruiting - verified June 2010 -
Gemcitabine and Docetaxel With Or Without Bevacizumab in Leiomyosarcoma, Malignant Fibrous Histiocytoma and Angiosarcoma
Posted: April 23rd, 2009, 9:00am CDT
Conditions: Sarcoma; Leiomyosarcoma; Malignant Fibrous; Histiocytoma; Angiosarcoma
Interventions: Drug: gemcitabine and docetaxel with bevacizumab; Drug: gemcitabine and docetaxel with placebo
Sponsors: Memorial Sloan-Kettering Cancer Center; Genentech
Active, not recruiting - verified August 2010 -
BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors
Posted: September 5th, 2007, 9:00am CDT
Conditions: Breast Cancer; Endometrial Cancer; Head and Neck Cancer; Melanoma (Skin); Ovarian Cancer; Sarcoma
Interventions: Drug: BI 2536; Other: high performance liquid chromatography; Other: mass spectrometry; Other: pharmacological study
Sponsor: European Organization for Research and Treatment of Cancer
Active, not recruiting - verified May 2010 -
Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma
Posted: December 11th, 2006, 9:00am CST
Conditions: Ovarian Cancer; Sarcoma; Small Intestine Cancer
Interventions: Drug: brostallicin; Drug: doxorubicin hydrochloride
Sponsor: European Organization for Research and Treatment of Cancer
Active, not recruiting - verified July 2010 -
Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma
Posted: June 28th, 2006, 9:00am CDT
Conditions: Childhood Malignant Fibrous Histiocytoma of Bone; Sarcoma
Interventions: Drug: doxorubicin hydrochloride; Drug: ifosfamide; Other: clinical observation; Procedure: therapeutic conventional surgery; Radiation: radiation therapy
Sponsors: Children's Oncology Group; National Cancer Institute (NCI)
Recruiting - verified August 2010 -
Bevacizumab in Treating Patients With Angiosarcoma
Posted: February 6th, 2006, 9:00am CST
Condition: Sarcoma
Intervention: Biological: Bevacizumab
Sponsors: Northwestern University; Genentech
Active, not recruiting - verified May 2010 -
Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma
Posted: June 5th, 2003, 9:00am CDT
Condition: Sarcoma
Interventions: Biological: pegfilgrastim; Drug: doxorubicin hydrochloride; Drug: ifosfamide; Procedure: multimodality therapy
Sponsor: European Organization for Research and Treatment of Cancer
Active, not recruiting - verified July 2009 -
Brostallicin in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma
Posted: July 8th, 2002, 9:00am CDT
Conditions: Gastrointestinal Stromal Tumor; Sarcoma
Intervention: Drug: brostallicin
Sponsor: European Organization for Research and Treatment of Cancer
Active, not recruiting - verified August 2002